| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0040 | AFAP1-AS1 | esophageal squamous cell carcinoma | overexpression, Kaplan-Meier survival analysis | cisplatin-resistant and parental ESCC cell lines | up-regulated | expression | High expression of AFAP1-AS1 could serve as a potential biomarker to predict tumor response and survival. Determination of this lncRNA expression might be useful for selection ESCC patients for dCRT. | 26756568 | |
| EL0246 | BOK-AS1 | esophageal squamous cell carcinoma | qPCR, Western blot, RIP etc. | ESCC tissue | up-regulated | interaction | LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance.WISP1 facilitated its own expression in response to radiation, creating a positive feedback loop and increased radioresistance. Our study revealed WISP1 as a potential target to overcome radioresistance in ESCC. | 25749038 | Lnc2Cancer |
| EL0260 | C5orf66-AS1 | esophageal squamous cell carcinoma | microarray, qPCR etc. | cell lines (KYSE510, KYSE450, KYSE150, KYSE30, EC109, TE-1) | down-regulated | expression | We identified a novel nuclear-retained lncRNA, named Epist, which is generally highly expressed in esophagus, and which is down-regulated during ESCC progression. Epist over-expression and knockdown studies further suggest that Epist inhibits the metastasis, acting as a tumor suppressor in ESCC. Collectively | 26158411 | Lnc2Cancer |
| EL0273 | CASC9 | esophageal squamous cell carcinoma | LncRNA array, qRT-PCR, knockdown | Primary tumor tissue from four esophageal squamous cell carcinoma (ESCC) patients. | up-regulated | expression | ESCCAL-1 is overexpressed in 65% of an independent ESCC patient cohort (n=26). More over, knockdown of ESCCAL-1 expression increases esophageal cancer cell apoptosis and reduces the invasion in vitro. ESCCAL-1 is a novel putative onco-lncRNA in esophageal cancer development. | 25885227 | |
| EL0273 | CASC9 | esophageal squamous cell carcinoma | lncRNA microarray, qRT-PCT | esophageal squamous cell carcinoma (ESCC) tissue | up-regulated | expression | ESCCAL_1 and HOTAIR may participate in the pathological process of ESCC. Furthermore, lncRNA could be potential diagnostic and prognostic biomarkers for ESCC. | 25297587 | |
| EL0273 | CASC9 | esophageal squamous cell carcinoma | microarray, qPCR etc. | ESCC tissue | up-regulated | expression | In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5. | 24222893 | LncRNADisease Lnc2Cancer |
| EL0274 | CBR3-AS1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) | up-regulated | expression | Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. | 24337686 | LncRNADisease Lnc2Cancer |
| EL0278 | CCAT2 | esophageal squamous cell carcinoma | qPCR etc. | ESCC tissue, cell lines (KYSE410) | up-regulated | expression | In silico analysis showed that no CpG island is found in the chromosome region of CCAT2, indicating that the expression of CCAT2 is possibly not regulated by DNA methylation.Compared with paired adjacent normal esophageal tissues, CCAT2 was significantly overexpressed in ESCC tissues with an average fold of 7.18. In ESCC cell lines, CCAT2 was mostly upregulated in KYSE410 cell when normalized to normal esophageal epithelium cell line (HEEC) and most CCAT2 transcripts were located in nucleus (>95 %). Statistical analysis showed that CCAT2 expression level was significantly associated with smoking status. | 25677908 | Lnc2Cancer |
| EL0278 | CCAT2 | esophageal squamous cell carcinoma | qPCR etc. | ESCC tissue | up-regulated | expression | CCAT2 was upregulated in ESCC tissues, especially in cases with lymph node metastasis (LNM), advanced TNM stages, and MYC amplification. Furthermore, the level of CCAT2 was positively correlated with TNM stages, LNM, and the number of positive lymph nodes. High CCAT2 expression and MYC amplification were significantly associated with TNM stages and LNM. CCAT2 may have great potential prognostic value for assessing postoperative ESCC patients. | 25919911 | Lnc2Cancer |
| EL0289 | CDKN2B-AS1 | esophageal squamous cell carcinoma | qPCR, Western blot, knockdown etc. | ESCC tissue, cell lines (TE1, ECA109) | up-regulated | regulation | ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma. | 24747824 | LncRNADisease Lnc2Cancer |
| EL0454 | ENST00000435885.1 | esophageal squamous cell carcinoma | microarray, qPCR etc. | OSCC tissue | differential expression | N/A | we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. | 24522499 | Lnc2Cancer |
| EL0473 | LINC01234 | esophageal squamous cell carcinoma | microarray, qPCR etc. | OSCC tissue | differential expression | N/A | we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. | 24522499 | Lnc2Cancer |
| EL0481 | ESCCAL-5 | esophageal squamous cell carcinoma | microarray, qPCR etc. | ESCC tissue | up-regulated | expression | In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5. | 24222893 | LncRNADisease Lnc2Cancer |
| EL0509 | FOXCUT | esophageal squamous cell carcinoma | qPCR, knockdown etc. | esophageal suqmous cell cancer tissue, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) | up-regulated | expression | Notably elevated FOXCUT and FOXC1 expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues, showing strong correlations with poor differentiation, advanced lymph node classification and metastasis. The expression of FOXCUT was positively correlated with expression of FOXC1 in ESCC specimens. And the expression of FOXC1 was also decreased as the FOXCUT expression was silenced by siRNA. Assays in vitro demonstrated that knockdown of either FOXCUT or FOXC1 remarkably inhibited cell proliferation, colony formation, migration, invasion in ESCC cells. | 25031703 | Lnc2Cancer |
| EL0556 | H19 | esophageal squamous cell carcinoma | N/A | N/A | N/A | regulation | Control of imprinting. Containing miRNA miR-675. | 22996375 | LncRNADisease |
| EL0556 | H19 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (TE-1 ,Eca-109) | down-regulated | regulation | Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. | 24706416 | LncRNADisease Lnc2Cancer |
| EL0575 | HNF1A-AS1 | esophageal squamous cell carcinoma | qPCR etc. | blood (plasma and serum) | up-regulated | expression | Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. | 25608466 | Lnc2Cancer |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | lncRNA microarray, qRT-PCT | esophageal squamous cell carcinoma (ESCC) tissue | up-regulated | expression | ESCCAL_1 and HOTAIR may participate in the pathological process of ESCC. Furthermore, lncRNA could be potential diagnostic and prognostic biomarkers for ESCC. | 25297587 | |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | microarray, qPCR etc. | ESCC tissue | up-regulated | expression | Expression of HOTAIR lncRNA is increased in various cancers, and it is also significantly increased in our analysis of ESCC. | 24222893 | LncRNADisease Lnc2Cancer |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | microarray, qPCR, Western blot, knockdown etc. | ESCC tissue, cell lines (KYSE30, KYSE140, KYSE180, KYSE410, KYSE510) | up-regulated | N/A | It was found that there was a great upregulation of HOTAIR in ESCC compared to their adjacent normal esophageal tissues. Meanwhile, patients with high HOTAIR expression have a significantly poorer prognosis than those with low expression. Moreover, HOTAIR was further validated to promote migration and invasion of ESCC cells in vitro. | 24118380 | Lnc2Cancer |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | N/A | N/A | N/A | expression | Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? | 24757675 | LncRNADisease |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | N/A | N/A | N/A | expression | The result showed that the expression levels of HOTAIR were upregulated in samples from patients with higher tumor burdens, which were defined as those with larger tumors, advanced clinical staging, increased lymph node tumor burdens and the presence of distant metastases.? | 24817925 | LncRNADisease |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | qPCR, in vitro knockdown etc. | ESCC tissu, cell lines (TE1, TE3, TE7, TE8, KYSE30, KYSE180 etc.) | up-regulated | regulation | Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. | 24022190 | LncRNADisease Lnc2Cancer |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | qPCR, ISH etc. | ESCC tissue | up-regulated | N/A | High expression levels of HOTAIR in ESCC patients correlated positively with clinical stage, TNM classification, histological differentiation and vital status. HOTAIR expression was found to be an independent prognostic factor in ESCC patients. ESCC patients who expressed high levels of HOTAIR had substantially lower overall 5-year survival rates than HOTAIR-negative patients. In vitro assays of ESCC cell lines demonstrated that HOTAIR mediated the proliferation, colony formation and migratory capacity of ESCC cells. | 23717443 | Lnc2Cancer |
| EL0578 | HOTAIR | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (KYSE30, KYSE150, KYSE450, KYSE510, KYSE180 etc.) | up-regulated | N/A | Notably elevated HOTAIR expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues (96%, P < 0.01), showing a high correlation with cancer metastasis (P < 0.01), elevated TNM (2009) stage classification (P < 0.01), and lowered overall survival rates (P = 0.003). Multivariate analysis revealed that HOTAIR expression (P = 0.003) is also an independent prognostic factor for comparison of TNM stage (P = 0.024) and lymph node metastasis (P = 0.010). | 24151120 | Lnc2Cancer |
| EL0672 | LINC00951 | esophageal squamous cell carcinoma | biochemical assays | N/A | N/A | N/A | functional polymorphism rs11752942A>G in lincRNA-uc003opf.1 exon might be a genetic modifier for the development of ESCC. | 23872665 | |
| EL0690 | LINC01233 | esophageal squamous cell carcinoma | microarray, qPCR etc. | OSCC tissue | differential expression | N/A | we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. | 24522499 | Lnc2Cancer |
| EL0695 | LINC01426 | esophageal squamous cell carcinoma | qPCR, Luciferase reporter assay, Western blot etc. | ESCC tissue | up-regulated | expression | We found that lincRNA-uc002yug.2 was commonly overexpressed in ESCC. Moreover, lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPa (CCAAT/enhancer-binding protein-a) gene expression, thereby promoting ESCC progression. The expression levels of lincRNA-uc002yug.2 in ESCC might be a prognostic factor for survival. | 25486427 | Lnc2Cancer |
| EL0853 | MALAT1 | esophageal squamous cell carcinoma | qPCR etc. | ESCC tissue | up-regulated | expression | MALAT1 expression was increased in ESCC tissue than in adjacent normal tissue samples (P< 0.001). MALAT1 level was positively related to pT stage (P= 0.01). | 26406400 | Lnc2Cancer |
| EL0853 | MALAT1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | esophageal squamous cell carcinoma and adjacent nonneoplastic tissues, cell lines(TE1, KYSE30, KYSE70, KYSE150, KYSE270, KYSE410, EC9706) | up-regulated | expression | Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase | 26493997 | Lnc2Cancer |
| EL0853 | MALAT1 | esophageal squamous cell carcinoma | qPCR, Luciferase reporter assay etc. | ESCC tissue, cell lines (KYSE30, KYSE150, KYSE450) | up-regulated | regulation | In this study, we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated upregulation of P21 and P27 expression and the inhibition of B-MYB expression. | 25538231 | Lnc2Cancer |
| EL0853 | MALAT1 | esophageal squamous cell carcinoma | qPCR, Western blot, knockdown etc. | ESCC tissue, cell lines (EC109, EC9706, KYSE150, KYSE450) | up-regulated | expression | MALAT1 was over-expressed in 46.3% of ESCC tissues, mostly in the high-stage tumor samples. Enhanced MALAT1 expression levels were positively correlated with clinical stages, primary tumor size, and lymph node metastasis. Inhibition of MALAT1 suppressed tumor proliferation in vitro and in vivo, as well as the migratory and invasive capacity.MALAT1 serves as an oncogene in ESCC, and it regulates ESCC growth by modifying the ATM-CHK2 pathway. | 25613496 | Lnc2Cancer |
| EL0853 | MALAT1 | esophageal squamous cell carcinoma | qRT-PCR | 106 paired ESCC tissues | down-regulated | N/A | MALAT1 decreased tumor formation and improved survival | 27015363 | |
| EL0872 | MINA | esophageal squamous cell carcinoma | N/A | N/A | N/A | regulation | Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? | 24757675 | LncRNADisease |
| EL0973 | NEAT1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (SHEE, SHEEC) | up-regulated | expression | We found that the expression of NEAT1 was higher in ESCC tissues and cells compared with the normal counterparts. Pearson analysis showed that elevated NEAT1 levels were extraordinarily correlated with the tumor size (P=0.026), lymph node metastasis (P=0.035) and clinical stage (P=0.004). | 26609486 | Lnc2Cancer |
| EL1007 | NPTN-IT1 | esophageal squamous cell carcinoma | reverse transcription‑quantitative polymerase chain reaction | primary ESCC tissues and healthy tissues | down-regulated | N/A | LET was observed to inhibit the migration and invasion of ESCC cells | 26935396 | |
| EL1052 | PCAT1 | esophageal squamous cell carcinoma | qPCR etc. | ESCC tissue | up-regulated | interaction | The expression of PCAT-1 was significantly higher in human ESCC compared with the adjacent noncancerous tissues (70.8 %, p < 0.01), and the high level of PCAT-1 expression was significantly correlated with invasion of the tumor (p = 0.024), advanced clinical stage (p = 0.003), lymph node metastasis (p = 0.032), and poor prognosis. | 25731728 | Lnc2Cancer |
| EL1077 | linc-POU3F3 | esophageal squamous cell carcinoma | qPCR etc. | blood (plasma and serum) | up-regulated | expression | Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. | 25608466 | Lnc2Cancer |
| EL1077 | linc-POU3F3 | esophageal squamous cell carcinoma | qPCR, Western blot, Luciferase reporter assay, RIP etc. | ESCC tissue | up-regulated | N/A | Levels of a lincRNA encoded by a gene located next to POU3F3 (linc-POU3F3) were significantly higher in ESCC than neighboring nontumor tissues. In RNA immunoprecipitation assays, linc-POU3F3 was associated with the EZH2 messenger RNA (mRNA). Overexpression of linc-POU3F3 in cell lines increased their proliferation and ability to form colonies, and reduced the expression of POU3F3 mRNA, whereas knockdown of linc-POU3F3 increased the levels of POU3F3 mRNA. | 24631494 | Lnc2Cancer |
| EL1236 | SOX2-OT | esophageal squamous cell carcinoma | N/A | N/A | N/A | expression | The results revealed a significant co-upregulation of SOX2OT along with SOX2 and OCT4 in tumor samples, compared to the non-tumor tissues obtained from the margin of same tumors. Therefore, the SOX2 gene might be a indicator for the early diagnosis of ESCC. | 24817925 | LncRNADisease |
| EL1236 | SOX2-OT | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (NT2, U-87 MG etc.) | up-regulated | N/A | Our data revealed a high level of SOX2OT expression in tumor samples of ESCC, compared to that of apparently normal marginal tissues obtained from the same patients (P<0.01). All together, our data provide a novel regulatory mechanism governing the key stem cell pluripotency genes, SOX2 and OCT4, mediated by the lncRNA SOX2OT. | 24105929 | Lnc2Cancer |
| EL1237 | SOX2OT-S1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (NT2, U-87 MG etc.) | up-regulated | N/A | The results of qPCR revealed that SOX2OT-S1 and SOX2OT-S2 were overexpressed in tumor samples of ESCC, compared to their marginal non-tumor tissue counterparts. Furthermore, overexpression of SOX2OT-S2 in tumor samples, similar to SOX2 and OCT4, was statistically significant (P<0.01). | 24105929 | Lnc2Cancer |
| EL1238 | SOX2OT-S2 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (NT2, U-87 MG etc.) | up-regulated | N/A | The results of qPCR revealed that SOX2OT-S1 and SOX2OT-S2 were overexpressed in tumor samples of ESCC, compared to their marginal non-tumor tissue counterparts. Furthermore, overexpression of SOX2OT-S2 in tumor samples, similar to SOX2 and OCT4, was statistically significant (P<0.01). | 24105929 | Lnc2Cancer |
| EL1240 | SPRY4-IT1 | esophageal squamous cell carcinoma | qPCR etc. | blood (plasma and serum) | up-regulated | expression | Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. | 25608466 | Lnc2Cancer |
| EL1240 | SPRY4-IT1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (KYSE-450, KYSE-510, KYSE-150 etc.) | up-regulated | expression | Long?noncoding?RNA?SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. | 24810925 | LncRNADisease Lnc2Cancer |
| EL1351 | TP73-AS1 | esophageal squamous cell carcinoma | microarray, knockdown | esophageal squamous cell carcinoma, mouse xenografts | up-regulated | interaction | In mouse xenografts, tumor size was reduced in lncRNA TP73-ASI siRNA-transfected tumors, suggesting that downregulation of lncRNA TP73-AS1 attenuated EC proliferation in vitro and in vivo. lncRNA TP73-AS1 knockdown enhanced the chemosensitivity of esophageal cancer cells to 5-FU and cisplatin. | 26799587 | |
| EL1399 | TUG1 | esophageal squamous cell carcinoma | qPCR, knockdown, FCA etc. | ESCC tissue | up-regulated | interaction | TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer. Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. | 25366138 | Lnc2Cancer |
| EL1402 | TUSC7 | esophageal squamous cell carcinoma | qPCR, knockdown etc | ESCC tissue, cell lines (KYSE30, KYSE 70, KYSE 150, KYSE510, Eca109) | down-regulated | N/A | LOC285194 expression was significantly down-regulated in ESCC tumor tissues when compared with the adjacent normal tissues. Low expression of LOC285194 was associated with larger tumor size, advanced TNM stage, more lymph node metastases and distant metastases. | 25169763 | LncRNADisease Lnc2Cancer |
| EL1431 | UCA1 | esophageal squamous cell carcinoma | qPCR, knockdown etc. | ESCC tissue, cell lines (EC109, EC9706, KYSE150, KYSE510) | up-regulated | expression | The relative level of UCA1 was significantly higher in ESCC tissues, and remarkably higher expression of UCA1 was found in esophageal cancer cell lines compared with the immortalized esophageal epithelial cell line NE1. The ESCC patients with higher UCA1 expression had an advanced clinical stage and a poorer prognosis than those with lower expression. In vitro assays, our data indicated that downregulation of UCA1 decrease cell proliferation, migration, and invasion ability. | 25550835 | Lnc2Cancer |
| EL1515 | ZEB1-AS1 | esophageal squamous cell carcinoma | qPCR etc. | ESCC tissues and adjacent non-tumor tissues | up-regulated | expression | LNCRNA ZEB1-AS1 was found up-regulated in ESCC tissues compared to adjacent non-tumor tissues. Increased lncRNA ZEB1-AS1 expression was significantly associated with tumor grade, depth of invasion, and lymph node metastasis. Kaplan-Meier analysis revealed that ESCC patients with high ZEB1-AS1 expression had a poorer overall survival and disease-free survival. Furthermore, multivariate analysis suggested that ZEB1-AS1 expression was identified as an independent prognostic factor in patients with ESCC | 26617942 | Lnc2Cancer |