| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| hepatocelluar carcinoma |
microarray, qPCR, RIP, RNA pulldown assay etc. |
HCC tissue |
down-regulated |
N/A |
AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. |
21769904 |
Lnc2Cancer
|
| hepatocelluar carcinoma |
N/A |
N/A |
N/A |
expression |
Importantly, another lncRNA-LET (lncRNA low expression in tumor) is found to play a critical role in hypoxia-induced metastasis in HCC |
24296588 |
LncRNADisease
|
| gastric cancer |
qPCR etc. |
gastric cancer tissue |
down-regulated |
expression |
We found that lncRNA LET expression was markedly down-regulated in tumor tissues compared with adjacent non-tumor tissues, and associated with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage. Univariate and multivariate analyses showed that low lncRNA LET expression was an independent poor prognostic factor for gastric cancer patients. |
25674261 |
Lnc2Cancer
|
| cervical cancer |
qPCR etc. |
cervical cancer tissue |
down-regulated |
expression |
The results showed that lncRNA LET expression in cervical cancer tissues was significantly down-regulated compared with the adjacent non-tumor tissues (P < 0.05). Decreased lncRNA LET expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion (P < 0.05), but not other clinical characteristics. |
25755778 |
Lnc2Cancer
|
| gallbladder cancer |
qPCR, Western blot, FCA etc. |
gallbladder cancer tissue, cell lines (GBC-SD, SGC-996, NOZ, EH-GB2) |
down-regulated |
expression |
In the present study, an obvious down-regulation of lncRNA-LET was observed in gallbladder cancer compared to their adjacent normal tissues. Meanwhile, patients with low expression of lncRNA-LET have significantly poorer prognosis than those with high expression. We confirmed that hypoxia decreased lncRNA-LET levels in gallbladder cancer cells. Moreover, lncRNA-LET overexpression was further validated to inhibit the invasion of gallbladder cancer cells under hypoxic or normoxic conditions in vitro. We demonstrated that lncRNA-LET overexpression conferred a proliferative advantage to tumor cells under hypoxic conditions. |
25213660 |
Lnc2Cancer
|
| lung squamous cell carcinoma |
qPCR, Western blot, in vitro knockdown, RIP etc. |
LSCC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) |
down-regulated |
expression |
In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. |
23395002 |
LncRNADisease Lnc2Cancer
|
| colorectal cancer |
qPCR, Western blot, in vitro knockdown, RIP etc. |
CRC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) |
down-regulated |
expression |
Aberrant Expression of lncRNA-LET in Tumor Tissue. In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. |
23395002 |
LncRNADisease Lnc2Cancer
|
| hepatocelluar carcinoma |
qPCR, Western blot, in vitro knockdown, RIP etc. |
HCC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) |
down-regulated |
expression |
In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. |
23395002 |
LncRNADisease Lnc2Cancer
|
| nasopharyngeal carcinoma |
qPCR, Western blot, knockdown etc. |
NPC tissue, cell lines (CNE2, HNE2) |
down-regulated |
interaction |
We found that lncRNA-LET was significantly downregulated in nasopharyngeal carcinoma (NPC) tissues compared with corresponding normal tissues. Decreased LET expression is significantly correlated with advanced clinical stage, larger tumor size, increased lymph node tumor burden, and poor survival of NPC patients. Knockdown of LET promoted NPC cells proliferation and inhibited cell apoptosis. Importantly, we found lncRNA-LET is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter. The expressions of EZH2 and lncRNA-LET are significantly inversely correlated in NPC tissues. |
26243049 |
Lnc2Cancer
|
| esophageal squamous cell carcinoma |
reverse transcription‑quantitative polymerase chain reaction |
primary ESCC tissues and healthy tissues |
down-regulated |
N/A |
LET was observed to inhibit the migration and invasion of ESCC cells |
26935396 |
|
| |