LncRNA Information
ID EL0575 Name HNF1A-AS1 Aliases C12orf27; NCRNA00262
Species Homo sapiens Chromosome 12 Start site 120941728
End site 120980965 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class retained intron NCBI accession NR_024345
Ensembl ENSG00000241388 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
nasopharyngeal carcinoma knockdown, colony-formation, wound-healing, and transwell assays, cell cycle analysis, western blot analysis tumor tissues from 20 patients with nasopharyngeal carcinoma (NPC) as well as from cultured NPC cell lines N/A expression LncRNA, HNF1A-AS potentially regulates NPC tumorigenesis. HNF1A-AS was found to be associated with epithelial to mesenchymal transition. 26756620
gastric cancer microarray, qPCR etc. GC tissue, cell lines (AGS, BGC-823, MKN-45) down-regulated interaction LncRNAs microarray analysis results exhibited that HNF1A-AS1 was downregulated in GCs tissues (mean fold change 2.06, p < 0.05), which was further confirmed by qRT-PCR. The results from qRT-PCR showed that the expression of HNF1A-AS1 was not only downregulated in three GC cell lines (AGS, BGC-823, and MKN-45) relative to that in a normal gastric mucosal epithelial cell line (GES-1), but also decreased in GC tissues relative to that in paired adjacent non-neoplastic tissues (low expression, 94 of 161; low expression rate, 58.38%). Furthermore, low HNF1A-AS1 expression was associated with tumor size/diameter (p = 0.005, multivariate analysis), levels of serum carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), and RRM1 expression in tissue samples 26472090 Lnc2Cancer
esophageal adenocarcinoma microarray, RNA-seq, qPCR, Western bolt, knockdown etc. esophageal adenocarcinoma tissue, cell lines (HEEpiC, SKGT-4, OE33 etc.) up-regulated regulation Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. 24000294 LncRNADisease Lnc2Cancer
hepatocellular carcinoma N/A HCC tissue and cell line up-regulated N/A sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2 27084450
esophageal squamous cell carcinoma qPCR etc. blood (plasma and serum) up-regulated expression Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. 25608466 Lnc2Cancer
lung adenocarcinoma qPCR, Western blot, knockdown, RIP etc. lung adenocarcinoma tissue, cell lines (A549, SPC-A1, H1650) up-regulated interaction HNF1A-AS1 was significantly up-regulated in lung adenocarcinoma tissues compared with corresponding non-tumor tissues, and its expression level was significantly correlated with TNM stage, tumor size, and lymph node metastasis. Moreover, HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and β-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. 25863539 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
cyclin D1, E-cadherin, N-cadherin and β-catenin RNA-Protein regulation HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and β-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. 25863539
CEA, CA19-9, RRM1 RNA-Protein regulation Low HNF1A-AS1 expression was associated with tumor size/diameter (p = 0.005, multivariate analysis), levels of serum carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), and RRM1 expression in tissue samples (p = 0.028, p = 0.009, and p = 0.006, respectively). 26472090
Bcl-2 RNA-Protein regulation HNF1A-AS1 functioned as an oncogene in tumor growth and apoptosis through sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2. 27084450
miR-30b RNA-RNA binding HNF1A-AS1 functioned as an oncogene in tumor growth and apoptosis through sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2. 27084450