LncRNA Information
ID EL1351 Name TP73-AS1 Aliases KIAA0495; PDAM
Species Homo sapiens Chromosome 1 Start site 3735601
End site 3747336 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_033709, NR_033710, NR_033711, NR_033708, NR_033712
Ensembl ENSG00000227372 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
multiple myeloma methylation-specific PCR etc. cell lines (KMS-12-PE, LP-1, NCI-H929, OPM-2, OCI-MY5) differential expression expression Herein, by methylation-specific PCR, the putative KIAA0495 promoter was found unmethylated in all healthy controls (N = 14) but methylated in 50 % of myeloma cell lines (N = 10). KIAA0495 methylation was shown inversely correlated with KIAA0495 expression. However, KIAA0495 methylation was detected in none of both primary myeloma samples at diagnosis (N = 61) and at relapse/progression (N = 16). Collectively, despite frequently methylated in cell lines, KIAA0495 methylation appeared unimportant in the pathogenesis or progression of myeloma. 26410378 Lnc2Cancer
esophageal squamous cell carcinoma microarray, knockdown esophageal squamous cell carcinoma, mouse xenografts up-regulated interaction In mouse xenografts, tumor size was reduced in lncRNA TP73-ASI siRNA-transfected tumors, suggesting that downregulation of lncRNA TP73-AS1 attenuated EC proliferation in vitro and in vivo. lncRNA TP73-AS1 knockdown enhanced the chemosensitivity of esophageal cancer cells to 5-FU and cisplatin. 26799587
non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression Furthermore, the levels of LINC00261 and TP73-AS1 were significantly differently expressed in subgroups of NSCLC samples (P = 0.004 and P = 0.03, respetcively). These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
BDH2 RNA-Protein regulation LncRNA TP73-AS1 knockdown inhibited BDH2 expression in EC9706 and KYSE30 cells. 26799587