Related LncRNAs
ID	lncRNA Name	Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
EL0509	FOXCUT	oral squamous cell carcinoma	qPCR, Western blot, knockdown etc.	OSCC tissue, cell lines (Tca8113, OSC-4, SCC1 etc.)	up-regulated	N/A	In this study, we report a new lncRNA FOXC1 upstream transcript (FOXCUT) that was remarkably overexpressed in 23 OSCC patients, as was the adjacent FOXC1 gene. The expressions of FOXC1 and FOXCUT were positively correlated. In conclusion, FOXC1 may be co-amplified with FOXCUT in OSCC, and both of them may be functionally involved in the tumor progression of OSCC.	24889262	Lnc2Cancer
EL0578	HOTAIR	oral squamous cell carcinoma	N/A	N/A	N/A	expression	Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA1 in metastasized samples was prominent higher than the non-metastatic samples.?	24817925	LncRNADisease
EL0578	HOTAIR	oral squamous cell carcinoma	qPCR etc.	OSCC tissues	up-regulated	N/A	We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.	23292713	Lnc2Cancer
EL0578	HOTAIR	oral squamous cell carcinoma	qPCR, Western blot, knockdown etc.	OSCC tissue, cell lines (TSCCA, Tca8223 etc.)	up-regulated	N/A	Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma.	25901533	LncRNADisease Lnc2Cancer
EL0853	MALAT1	oral squamous cell carcinoma	qPCR, Western blot, knockdown etc.	OSCC tissue, cell lines (Tscca, Tca8113P160, Tca8113, Hep-2)	up-regulated	interaction	We found that MALAT1 is overexpressed in OSCC tissues compared to normal oral mucosa by real-time PCR. MALAT1 served as a new prognostic factor in OSCC patients. When knockdown by small interfering RNA (siRNA) in OSCC cell lines TSCCA and Tca8113, MALAT1 was shown to be required for maintaining epithelial-mesenchymal transition (EMT) mediated cell migration and invasion. Western blot and immunofluorescence staining showed that MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro. Meanwhile, both nucleus and cytoplasm levels of β-catenin and NF-B were attenuated, while elevated MALAT1 level triggered the expression of β-catenin and NF-B. More importantly, targeting MALAT1 inhibited TSCCA cell-induced xenograft tumor growth in vivo.	26522444	Lnc2Cancer
EL0861	MEG3	oral squamous cell carcinoma	qPCR etc.	OSCC tissues	down-regulated	N/A	We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.	23292713	Lnc2Cancer
EL0973	NEAT1	oral squamous cell carcinoma	N/A	N/A	N/A	expression	Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA2 in metastasized samples was prominent higher than the non-metastatic samples.?	24817925	LncRNADisease
EL0973	NEAT1	oral squamous cell carcinoma	qPCR etc.	OSCC tissues	up-regulated	N/A	We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.	23292713	Lnc2Cancer
EL1431	UCA1	oral squamous cell carcinoma	N/A	N/A	N/A	expression	Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA3 in metastasized samples was prominent higher than the non-metastatic samples.?	24817925	LncRNADisease
EL1431	UCA1	oral squamous cell carcinoma	qPCR etc.	OSCC tissues	up-regulated	N/A	We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer.	23292713	Lnc2Cancer