INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1431	UCA1	171. C/EBPα-p30	RNA-Protein	regulation	we identified the oncogenic urothelial carcinoma associated 1 (UCA1) lncRNA as a novel target of the C/EBPα-p30.	26053097
EL1431	UCA1	Hyaluronoglucosaminidase 1 (HYAL1)	RNA-Protein	co-expression	There was a significant positive correlation between HYAL1 and the selected epigenetic biomarkers.	26138586
EL1431	UCA1	AKT/mTOR pathway	N/A	regulation	UCA1 may induce non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway and EMT.	26160838
EL1431	UCA1	Ets-2	DNA-Protein	binding	Ets-2 bound to the UCA1 core promoter using luciferase assays.	26238511
EL1431	UCA1	β-catenin	RNA-Protein	regulation	CUDR causes highly upregulated in liver cancer (HULC) and β-catenin abnormal expression by inhibiting HULC promoter methylation and promoting β-catenin promoter-enhancer chromatin looping formation mediated by CUDR-ccctc-binding factor (CTCF) complex, which recruits more RNA polII and P300.	26347501
EL1431	UCA1	histone H3 twenty-seventh lysine (H3K27me3)	RNA-Protein	regulation	CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like cells by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3).	26347501
EL1431	UCA1	miR-16	RNA-RNA	regulation	Urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells.	26373319
EL1431	UCA1	miR-143	RNA-RNA	binding	There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143.	26439035
EL1431	UCA1	H19	RNA-DNA	binding	CUDR-CyclinD1 complex loads onto the long noncoding RNA H19 promoter region that may lead to reduce the DNA methylation on H19 promoter region and then to enhance the H19 expression.	26513297
EL1431	UCA1	C-myc	RNA-DNA	binding	Insulator CTCF recruits the CUDR-CyclinD1 complx to form the composite CUDR-CyclinD1-insulator CTCF complex which occupancied on the C-myc gene promoter region, increasing the outcome of oncogene C-myc.	26513297
EL1431	UCA1	CyclinD1	RNA-Protein	binding	The decrease of PTEN in cells may lead to increase binding capacity of CUDR to CyclinD1.	26513297
EL1431	UCA1	ZEB1 and ZEB2	RNA-Protein	regulation	lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2)	26544536
EL1431	UCA1	hsa-miR-145	RNA-RNA	binding	The binding site for hsa-miR-145 within exons 2 and 3 of lncRNA-UCA1 contributed to the reciprocal negative regulation of lncRNA-UCA1 and hsa-miR-145.	26544536
EL1431	UCA1	KLF4	RNA-Protein	regulation	UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13.	26550172
EL1431	UCA1	SET1A	RNA-Protein	regulation	SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically	26581161
EL1431	UCA1	miR-193a-3p	RNA-RNA	binding	UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p.	26655272
EL1431	UCA1	MMP14	RNA-Protein	regulation	Depletion of UCA1 was involved in the downregulation of matrix metallopeptidase 14 (MMP14) expression, a target gene of miR-485-5p.	26867765
EL1431	UCA1	miR-485-5p	RNA-RNA	binding	UCA1 could function as an endogenous sponge by directly binding to miR-485-5p.	26867765
EL1431	UCA1	CREB1	RNA-Protein	regulation	CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression.	27046651
EL1431	UCA1	miR-204-5p	RNA-RNA	binding	UCA1 could sponge endogenous miR-204-5p and inhibit its activity.	27046651