INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1102	PVT1	c-Myc	DNA-TF	regulation	PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins.	17503467	LncRNADisease
EL1102	PVT1	c-Myc	RNA-DNA	regulation	PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins.	17503467	LncRNADisease
EL1102	PVT1	YY1	RNA-DNA	regulation	The risk allele (G) of rs378854 reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected.	21814516	LncRNADisease
EL1102	PVT1	P53	DNA-TF	regulation	The non-protein coding locus PVT1 is a p53-inducible target gene.	22110125	LncRNADisease
EL1102	PVT1	serum α-fetoprotein	RNA-Protein	regulation	overexpression of PVT1 was associated with a higher serum α-fetoprotein expression level (P=0.011) and a higher recurrence rate (P=0.004).	25624916
EL1102	PVT1	EZH2	RNA-Protein	binding	we further confirmed that PVT1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of p15 and p16	25890171
EL1102	PVT1	EZH2	RNA-Protein	regulation	lncRNA PVT1 could be enriched by EZH2, and silencing PVT1 resulted in the decreased recruitment of EZH2.	26427660
EL1102	PVT1	cyclin D1 and TSHR	RNA-Protein	regulation	Silenced PVT1significantly decreased cyclin D1 and TSHR expressions.	26427660
EL1102	PVT1	MYC	DNA-DNA	regulation	Significantly lower MYC and PVT1 expression was observed during all-trans retinoic acid (ATRA)-induced differentiation and cell cycle arrest in the APL cell line. MYC knockdown in NB4 cells led to PVT1 downregulation. Moreover, PVT1 knockdown by RNA interference led to suppression of the MYC protein level, and cell proliferation was inhibited.	26544536
EL1102	PVT1	LATS2	RNA-DNA	regulation	PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription.	26908628
EL1102	PVT1	EZH2	RNA-Protein	binding	PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription.	26908628