INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0555	H19	Igf2 of imprinted gene network (IGN)	RNA-Protein	regulation	We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene network (IGN) was performed in both loss- and gain-of-function animals. We found that H19 deletion leads to the upregulation of several genes of the IGN.	19762426
EL0555	H19	let-7	RNA-RNA	binding	Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7.	25399420
EL0555	H19	Igf2 (insulin-like growth factor 2)	RNA-DNA	regulation	This is associated with the disruption of igf2 imprinting and the consequent biallelic expression of this gene.	9203585
EL0556	H19	SERPINE1	RNA-RNA	co-expression	Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal.	10738131
EL0556	H19	IMP	RNA-Protein	binding	Human h19 rna contains four attachment sites for the oncofetal igf-ii mrna-binding protein (imp)	10875929
EL0556	H19	IMP-3	RNA-Protein	regulation	Imp-3 protein associates with igf-ii leader-3 and leader-4 mrnas and h19 rna	15753088
EL0556	H19	miR-675	RNA-RNA	co-expression	Recently, it was found that the H19 RNA is host to an exonic microRNA, miR-675, which, as a result, is also imprinted and maternally expressed.	19239885	LncRNADisease
EL0556	H19	c-myc	DNA-TF	regulation	H19 has been linked to the oncogene, c-myc, which positively regulates its expression in diverse cell types including T98G human glioblastoma cells.	20380817	LncRNADisease
EL0556	H19	p53	DNA-TF	regulation	H19 has been linked to the tumor suppressor, p53, which negatively regulates its expression.	20380817	LncRNADisease
EL0556	H19	GLI1	DNA-TF	regulation	H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas.	20380817	LncRNADisease
EL0556	H19	SHH	DNA-TF	regulation	H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas.	20380817	LncRNADisease
EL0556	H19	E2F1	RNA-Protein	regulation	H19 transcription is positively regulated by the cell cycle regulatory factor, E2F1, during the S-phase of growth-stimulated cells.	20380817	LncRNADisease
EL0556	H19	Igf2	RNA-RNA	co-expression	Complex functions, influences growth by down-regulating a number of imprinted genes including Igf2, also implicated as both a tumour suppressor and an oncogene.	21256239	LncRNADisease
EL0556	H19	CTCF1	RNA-RNA	co-expression	Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p?	22395465	LncRNADisease
EL0556	H19	CTCF2	RNA-RNA	co-expression	Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p<=0.05).	22395465	LncRNADisease
EL0556	H19	CTCF3	RNA-RNA	co-expression	There is a CTCF-binding site (CTCF3) in the imprinting control region (ICR) upstream of H19.	22395465	LncRNADisease
EL0556	H19	IGF2	RNA-Protein	regulation	H19 is an imprinted maternally expressed gene influencing IGF2 expression, whose transcript is a long noncoding (lnc) RNA of unknown biological function harboring the miR-675.	22527881
EL0556	H19	H19 transcript can counteract 91H-mediated Igf2 activation	RNA-RNA	regulation	A large excess of the H19 transcript can counteract 91H-mediated Igf2 activation.	22662250
EL0556	H19	Igf2	RNA-Protein	regulation	Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans	22662250
EL0556	H19	let-7 family of microRNAs	RNA-RNA	binding	Vertebrate H19 harbors both canonical and noncanonical binding sites for the let-7 family of microRNAs, which plays important roles in development, cancer, and metabolism.	24055342
EL0556	H19	H1.3	RNA-Protein	regulation	H1.3dramatically inhibits H19 expression, which contributes to the suppression of epithelial ovarian carcinogenesis.	25205099
EL0556	H19	K homology-type splicing regulatory protein (KSRP)	RNA-Protein	binding	KSRP directly binds to H19 in the cytoplasm of undifferentiated multipotent mesenchymal C2C12 cells	25385579
EL0556	H19	miR-138 and miR-200a	RNA-RNA	regulation	by using bioinformatics study and RNA immunoprecipitation combined with luciferase reporter assays, we demonstrated that H19 functioned as a competing endogenous RNA (ceRNA) for miR-138 and miR-200a, antagonized their functions and led to the de-repression of their endogenous targets Vimentin, ZEB1, and ZEB2, all of which were core marker genes for mesenchymal cells	26068968
EL0556	H19	MiR-141	RNA-RNA	binding	MiR-141 binds to H19 in a sequence specific manner, and suppresses H19 expression and functions including proliferation and invasion. MiR-141 could also regulate H19 target genes and miR-141 inhibitor restores H19 siRNA function, while H19 regulates miR-141 target gene ZEB1.	26160158
EL0556	H19	Yes-associated protein 1 (YAP1)	RNA-Protein	co-expression	H19 expression was found to be significantly associated with YAP1 expression. H19, at least in part, is induced by YAP1 overexpression.	26163939
EL0556	H19	miR-675	RNA-RNA	regulation	Ectopic expression of H19 significantly increased bladder cancer cell proliferation and miR-675 expression in vitro.	26198047
EL0556	H19	histone deacetylase (HDAC) 4/5	RNA-DNA	regulation	H19/miR-675 downregulated the mRNA and protein levels of histone deacetylase (HDAC) 4/5, and thus increased osteoblast marker gene expression.	26417995
EL0556	H19	transforming growth factor-β1 (TGF-β1)	RNA-DNA	regulation	H19/miR-675 inhibited mRNA and protein expression of transforming growth factor-β1 (TGF-β1).	26417995
EL0556	H19	c-Myc	RNA-Protein	regulation	H19 was a direct transcriptional target of c-Myc.	26482621
EL0556	H19	S-adenosylhomocysteine hydrolase (SAHH)	RNA-Protein	binding	The developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH)	26687445
EL0556	H19	c-Myc	DNA-DNA	regulation	The activity of the promoter of H19 was strengthened by c-Myc.	26722426
EL0556	H19	miR-107	RNA-RNA	regulation	The expression of miR-107 increased or decreased with the overexpression and knockdown of H19, respectively. The number of cells in G2/M stage decreased significantly with the knockdown of H19 and miR-107 compared with the control group.	26722426
EL0556	H19	heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin	RNA-Protein	regulation	H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression.	26801864
EL0556	H19	AKT2	RNA-RNA	co-expression	The RNA levels of H19 and AKT2 were positively correlated.	26803515
EL0556	H19	miR-141 and miR-22	RNA-RNA	binding	H19 functioned as an miRNA sponge for miR-141 and miR-22, both of which were negative regulators of osteogenesis and Wnt/β-catenin pathway.	26853553
EL0556	H19	HuR	RNA-Protein	regulation	H19 interacts with HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675 by altering ZO-1 and E-cadherin expression posttranscriptionally.	26884465
EL0556	H19	miR-675	RNA-RNA	regulation	H19 plays an important role in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA 675 (miR-675). H19 overexpression increased the cellular abundance of miR-675, which in turn destabilized and repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfunction of the epithelial barrier.	26884465
EL0556	H19	RUNX1	RNA-DNA	regulation	Overexpression of H19 or miR-675 significantly decreased RUNX1 expression in AGS cells, and knockdown of H19 or miR-675 enhanced RUNX1 expression.	26931432
EL0556	H19	miR-675	RNA-RNA	regulation	The expression of miR-675 was positively correlated with H19 in patients with gastric cancer.	26931432
EL0556	H19	eIF4A3	RNA-Protein	binding	eIF4A3 as an RNA-binding protein that binds to H19. Combining eIF4A3 with H19 obstructed the recruitment of eIF4A3 to the cell-cycle gene mRNA.	26989025
EL0556	H19	EZH2	RNA-DNA	regulation	H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner.	27040767
EL0556	H19	miR-630	RNA-RNA	regulation	H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner.	27040767
EL0556	H19	CaMKIIδ	RNA-Protein	regulation	CaMKIIδ was a direct target of miR-675 and partially mediated the effect of H19 on cardiomyocyte hypertrophy.	27084844
EL0556	H19	miR-675	RNA-RNA	regulation	H19 encoded miR-675.	27084844