LncRNA Information | ||||||
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ID | EL0555 | Name | H19 | Aliases | AI747191 | |
Species | Mus musculus | Chromosome | 7 | Start site | 142575529 | |
End site | 142578143 | Chain | minus | Exon NO. | 5 | |
Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_130974, NR_130973 | |
Ensembl | ENSMUSG00000000031 | Sequence |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
overgrowth | transgenic | embryos of mice lacking H19 | down-regulated | mutation | Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. | 19762426 | |||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
deletion of the H19 transcription | N/A | N/A | expression | The homozygous mutant animals are viable and fertile and display an overgrowth phenotype of 8% compared with wild-type littermates. | 9203585 | ||||
genetic complementation approach | H19 KO myoblast cells | N/A | interaction | Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans | 22662250 | ||||
knockdown, overexpression | N/A | N/A | interaction | H19 modulates let-7 availability by acting as a molecular sponge. H19 depletion causes precocious muscle differentiation, a phenotype recapitulated by let-7 overexpression. | 24055342 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
Igf2 of imprinted gene network (IGN) | RNA-Protein | regulation | We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene network (IGN) was performed in both loss- and gain-of-function animals. We found that H19 deletion leads to the upregulation of several genes of the IGN. | 19762426 | |||||
let-7 | RNA-RNA | binding | Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. | 25399420 | |||||
Igf2 (insulin-like growth factor 2) | RNA-DNA | regulation | This is associated with the disruption of igf2 imprinting and the consequent biallelic expression of this gene. | 9203585 | |||||