Related LncRNAs
ID lncRNA Name Disease Method Sample Expression pattern Dysfunction type Description PMID Source
EL0521 GADD45G pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated N/A In summary, MEG3 and GADD45γexpression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. 21850407 Lnc2Cancer
EL0556 H19 pituitary adenoma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0578 HOTAIR pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated expression Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. 24469926 LncRNADisease Lnc2Cancer
EL0853 MALAT1 pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated expression Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. 24469926 LncRNADisease Lnc2Cancer
EL0861 MEG3 pituitary adenoma N/A N/A N/A expression Another potential angiogenic lncRNA, Maternally expressed gene 3 (MEG3) was found to be silenced in pituitary adenomas.? 24829860 LncRNADisease
EL0861 MEG3 pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated N/A In summary, MEG3 and GADD45γ expression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. 21850407 Lnc2Cancer
EL0861 MEG3 pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated N/A MEG3 lncRNA levels gradually decreased whereas HOTAIR lncRNA levels gradually increased from normal anterior pituitaries to non-invasive NFPAs to invasive NFPAs. There was a significant association between MEG3 (P < 0.01) and HOTAIR (P < 0.05) expression and the biological behavior of the tumor. Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to non-invasive ones (P < 0.01). In addition, PCNA mRNA negatively correlated with MEG3 lncRNA levels 24469926 LncRNADisease Lnc2Cancer
EL0861 MEG3 pituitary adenoma qPCR, ISH etc. pituitary tumor tissue down-regulated N/A Therefore, RT-PCR was used to detect specific MEG3a isoform expression in different human pituitary tumor phenotypes. Figure 4B shows that there was no MEG3a expression in three GH-secreting tumors and eight clinically nonfunctioning pituitary tumors, in contrast to the five normal human pituitaries. 14602737 LncRNADisease Lnc2Cancer