LncRNA Information
ID	EL2382	Name	MALAT1	Aliases	HCN, LINC00047, NCRNA00047, NEAT2, PRO2853
Species	Homo sapiens	Chromosome	11	Start site	65497738
End site	65506516	Chain	plus	Exon NO.	2
Assembly	GRCh38.p13	Class	lincRNA	NCBI accession	NR_002819, NR_144567, NR_144568
Ensembl	ENSG00000251562	Sequence	NR_002819 NR_144567 NR_144568	Peptide-related	N/A
CircRNA	yes	Exosomal	yes	Structure	yes

Structure information
Structure view	PDB ID
	4PLX

Disease
Disease	Drug/chemo/stress	Method	Sample	Expression pattern	Dysfunction type	Description	PMID
multiple myeloma		qRT-PCR, Luciferase reporter assay, ELISA, knockdown	bone marrow	up-regulated	interaction	The expression of MALAT1 was assessed by quantitative qPCR. Consistently higher expression level of MALAT1 was found in MSCs from all 25 patient samples relative to that from healthy donors. lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoter to increase expression of LTBP3 gene. The specificity and efficiency of activation were ensured by the formation of a stable complex between MALAT1 and the LTBP3 promoter, direct interaction of MALAT1 with Sp1 and recruitment of Sp1 to the promoter.	25187517
esophageal squamous cell carcinoma		qRT-PCR, Luciferase reporter assay	ESCC tissue, cell lines (KYSE30, KYSE150, KYSE450)	up-regulated	interaction	In this study, we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated upregulation of P21 and P27 expression and the inhibition of B-MYB expression.	25538231
non-small cell lung cancer		qRT-PCR, knockdown, Luciferase reporter assay	NSCLC tissue, cell lines (A549, YTLMC-9)	up-regulated	interaction	MALAT1 is a non-coding RNA overexpressed in non-small cell lung cancer (NSCLC). TDP-43 is a ubiquitously expressed, MALAT1-binding protein implicated in cancer development. TDP-43 overexpression markedly increased MALAT1 transcript level. In summary, these findings demonstrated that MALAT1 expression by regulation of TDP-43 controls cellular growth, migration, and invasion of NSCLCs.	26265046
breast cancer		qRT-PCR, western blot, Luciferase reporter assays	breast cancer patients tissues	down-regulated	interaction	The effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells	26275461
cervical cancer		qRT-PCR, Luciferase reporter assays, knockdown, RIP, RNA pull-down	cervical cancer tissue, cell lines (HeLa and CaSki)	up-regulated	interaction	We found MALAT1 expression was significantly higher in radioresistant than in radiosensitive cancer cases. In addition, MALAT1 and miR-145 expression inversely changed in response to irradiation in HR-HPV+ cervical cancer cells. By using clonogenic assay and flow cytometry analysis of cell cycle distribution and apoptosis, we found CaSki and Hela cells with knockdown of MALAT1 had significantly lower colony formation, higher ratio of G2/M phase block and higher ratio of cell apoptosis.	26311052
hepatocellular carcinoma		N/A	hepatocellular carcinoma (HCC) tissues	up-regulated	interaction	N/A	26352013
renal cancer		qRT-PCR	clear cell renal cell carcinoma and corresponding noncancerous tissues	up-regulated	interaction	We found that MALAT1 exist a higher fold change (Tumor/Normal) in clear cell kidney carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) Data Portal and a negative correlation with miR-200s family. We further demonstrated MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly reverse the MALAT1's stimulation on proliferation and metastasis in KIRC. In summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the progression of KIRC.	26461224
nasopharyngeal carcinoma		qRT-PCR, western blot, Luciferase reporter assays, RIP	NPC cell lines (5-8F, CNE-2, HONE-1, SUNE-1), NPE cell line (NP-69)	up-regulated	interaction	We found that MALAT1 regulated radioresistance by modulating cancer stem cell (CSC) activity. Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. Taking these observations into consideration, we proposed that MALAT1 regulated CSC activity and radioresistance by modulating miR-1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients	26482776
prostate cancer		qRT-PCR, RIP-Seq, knockdown, ChIP	cell lines (C4-2, PC-3, LNCaP)	up-regulated	interaction	We showed that MALAT1 enhances expression of PRC2-independent target genes of EZH2 in CRPC cells in culture and patient-derived xenografts. Together, these data indicate that MALAT1 may be a crucial RNA cofactor of EZH2 and that the EZH2-MALAT1 association may provide a new avenue for development new strategies for treatment of CRPC.	26516927
glioma		qRT-PCR, western blot, Luciferase reporter assays, RIP, ChIP	glioma samples and normal brain tissues, cell lines (hCMEC/D3, ECs)	up-regulated	interaction	Our results proved that MALAT1 expression was up-regulated in brain microvessels of human glioma and glioma endothelial cells (GECs) which were obtained by co-culturing endothelial cells with glioma cells. Functionally, knockdown of MALAT1 resulted in an impairment and increased the permeability of BTB as well as decreased the expression of ZO-1, occludin and claudin-5 in GECs. Further, there was reciprocal repression between MALAT1 and miR-140, and miR-140 mediated the effects that MALAT1 knockdown exerted. Mechanistic investigations defined that nuclear factor YA (NFYA), a CCAAT box-binding transcription factor, was a direct and functional downstream target of miR-140, which was involved in the MALAT1 knockdown induced regulation of BTB function. Furthermore, NFYA could up-regulate the promoter activities and bind to the promoters of ZO-1, occludin and claudin-5 in GECs.	26619802
gastric cancer		RNA immunoprecipitation, RIP-seq	gastric cancer cell lines	N/A	interaction	suppresses the tumor suppressor PCDH10 and promotes gastric cellular migration and invasion	26871474
breast cancer		knockdown	breast cancer tissues and cells	up-regulated	interaction	MALAT1-siRNA inhibited breast cancer cell proliferation and cell cycle progression in vitro and in vivo; and downregulating miR-124 expression	26918449
plexiform fibromyxoma		overexpression, qRT-PCR, RNA-seq, FISH, immunohistochemistry	formalin-fixed, paraffin-embedded (FFPE) material	up-regulated	interaction	Plexiform fibromyxomas are rare neoplasms, being officially recognized as a distinct entity among benign mesenchymal gastric tumours in the 2010 WHO Classification of Tumours of the Digestive System. Characteristically, these tumours have a multinodular/plexiform growth pattern, and histologically contain variably cellular areas of bland myofibroblastic-type spindle cells embedded in an abundant myxoid matrix, rich in capillary-type vessels.	27101025
breast cancer		qRT-PCR, in situ hybridisation, overexpression	a large series of breast tumours from patients with known clinical/pathological status and long-term outcome	differential expression	interaction	A complex expression pattern of various MALAT1 transcript variants in breast tumours, and suggest that this pattern of expressions should be taken into account to evaluate MALAT1 as predictive biomarker and therapeutic target.	27172249
gallbladder cancer		overexpression, knockdown	gallbladder cancer (GBC) tissue and cells.	up-regulated	interaction	Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206.	27191262
lung adenocarcinoma			lung adenocarcinoma cells	up-regulated	interaction	A branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma. LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.	27294002
pancreatic ductal adenocarcinoma		knockdown,	PDAC tissues	up-regulated	interaction	MALAT1 is increased in pancreatic cancer and is identified as a diagnostic biomarker.	27371730
gallbladder carcinoma		western blot, qRT-PCR, knockdown, immunofluorescence assay	GBC tissues	up-regulated	interaction	The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer.	27420766
lipopolysaecharide-induced inflammation		knockdown,	lipopolysaccharide (LPS)-activated macrophages	up-regulated	interaction	MALAT1 may function as an autonegative feedback regulator of NF-κB to help fine-tune innate immune responses.	27434861
osteosarcoma		knockdown,	human OS cell lines and tissues	up-regulated	interaction	MALAT1 may promote OS cell growth through inhibition of MIR376A, leading to increased expression of TGFA. Our results suggest a MALAT1/MIR376A/TGFA axis mediates OS cell proliferation and tumor progression.	27458156
thyroid cancer		qRT-PCR, western blot	thyroid cancer cells	up-regulated	interaction	MALAT1 promoted the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1	27470543
gastric cancer		Knockdown, overexpression	gastric cancer patients with distant metastasis, without distant metastasis and the healthy controls	up-regulated	interaction	MALAT1 could inhibit cell proliferation, cell cycle progression, migration and invasion, and promote apoptosis in gastric cancer cells.he miR-122-IGF-1R signaling correlated with the dysregulated MALAT1 expression in gastric cancer.These data suggest that MALAT1 could function as an oncogene in gastric cancer, and high MALAT1 level could serve as a potential biomarker for the distant metastasis of gastric cancer.	27486823
melanoma			melanoma cells	up-regulated	interaction	Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22.	27564100
nasopharyngeal carcinoma		Microarray, knockdown,	NPC cells	up-regulated	interaction	RBM24 acts at least in part through upregulating the expression of miR-25, which in turn targets MALAT1 for degradation.	27584791
tongue squamous cell carcinoma		microarray, qRT-PCR, overexpression, knockdown,	TSCC samples as well as paired adjacent normal tissues	up-regulated	interaction	Enhanced expression of MALAT-1 is associated with the growth and metastatic potential of TSCCs. Knock down of MALAT-1 in TSCCs leads to the up-regulation of certain SPRR proteins, which influenced the distant metastasis of TSCC cells.	27586393
renal carcinoma		qRT-PCR, western blot,RNA pull-down, RIP	human tissues, renal carcinoma cell lines, and nude mice.	up-regulated	interaction	MALAT-1-mediated promotion of RCC proliferation and metastasis may be due to the upregulation of the expression of Livin.	27655020
endometrial endometrioid adenocarcinoma		luciferase reporter, qRT-PCR	tumor tissues	down-regulated	interaction	Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma.	27693631
thyroid cancer		situ hybridization (ISH),qRT-PCR	normal thyroid (NT) tissues and thyroid tumors	down-regulated	interaction	MALAT1 downregulation in certain thyroid malignancies	27696303
brain injury		knockdown, RNA immunoprecipitation	immortalized mouse hippocampal cell line (HT22) after injury		interaction	Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA contained in the hASC exosomes mediates PKCδII splicing, thereby increasing neuronal survival.	27841943
myocardial ischemia/reperfusion injury		qRT-PCR, knockdown,	cardiac muscle cell line from the AT-1 mouse	up-regulated	interaction	Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury	27862640
glioma		qRT-PCR, knockdown	glioma cells	down-regulated	interaction	Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by suppressing miR-155 expression and activating FBXW7 function.	27904771
prostate cancer		western blot, Microarray, RNA-ChIP	prostate cancer cells		interaction	Interestingly, upon treatment with17β-estradiol HOTAIR recruitment to chromatin increased significantly while that of MALAT1 was reduced, suggesting an opposite regulation and function for these lncRNAs.	27922078
malignant melanoma			melanoma tissues and cells		interaction	The expression and function of miR-183 were suppressed by MALAT1	27966454
mantle cell lymphoma		qRT-PCR,knockdown	MALAT1 in MCL cell lines	differential expression	interaction	Decreased phosphorylation of EZH2 at T350 attenuated the binding to MALAT1.	27998273
ovarian cancer		RNA-seq	ovarian cancer cell lines, clinical tumor samples	up-regulated	interaction	MALAT1 might be an oncogenic lncRNA that promotes proliferation of ovarian cancer and could be regarded as a therapeutic target in human ovarian cancer.	28031721
pancreatic ductal adenocarcinoma		qRT-PCR	pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues		interaction	MiR-216a overexpression and MALAT1 knockdown induced cell cycle arrest at G2/M phase.	28034748
colorectal cancer		knockdown	established HT29 oxaliplatin-resistant cells	up-regulated	interaction	LncRNA MALAT1 may serve as a promising prognostic and therapeutic target for colorectal cancer patients.	28069878
esophageal squamous cell carcinoma		gene transfection	ESCC cells	down-regulated	interaction	MALAT1 acts as an essential oncogene lncRNA (onco-lncRNA) in the development of ESCC.	28150831
pre-eclampsia		overexpression, knockdown	umbilical cord tissues and MSCs patients with severe PE	down-regulated	interaction	MALAT1 is an important endogenous regulator in the proliferation, angiogenesis, and immunosuppressive properties of MSCs, suggesting it may be involved in the pathogenesis of PE	28176360
glioblastoma multiforme		qRT-PCR, knockdown	tissues and serum samples	differential expression	interaction	Enhanced expression of lncRNA MALAT1 confers a potent poor therapeutic efficacy and inhibition of MALAT1 levels could be a future direction to develop a novel therapeutic strategy to overcome TMZ resistance in GBM patients.	28187000
tongue cancer		Knockdown	tongue cancer cell lines and clinical tongue cancer samples	up-regulated	interaction	We revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.	28260102
gastric cancer		in situ hybridization, knockdown	150 gastric cancer (GC) clinical specimens		interaction	MALAT1 can promote tumorigenicity and metastasis in GC by facilitating VM and angiogenesis via the VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways.	28268166
ewing sarcoma		microarray, ChIP-qRT-PCR, luciferase reporter, qRT-PCR	EWS patients and cell lines	up-regulated	interaction	Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate therapeutic targets.	28336564
osteosarcoma		Luciferase reporter assay, knockdown	OS cell lines	up-regulated	interaction	MALAT1 promoted OS cell growth through inhibition of miR-142-3p or miR-129-5p and by targeting HMGB1	28346809
gastric cancer		qRT-PCR, western-blot, Luciferase reporter assay	gastric carcinoma tissues, adjacent normal tissues	up-regulated	interaction	Long non-coding RNA MALAT1 drives gastric cancer progression by regulating HMGB2 modulating the miR-1297	28396617
hepatocellular carcinoma			hepatocellular carcinoma (HCC) patients		interaction	MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC.	28404923
lymphoma		microarray, Immunohistochemistry, RNA immunoprecipitation assay, western blot, qRT-PCR	T and NK cell lymphomas, B cell lymphoma	up-regulated	interaction	MALAT1 directly binds to EZH2 and SUZ12, and BMI1 activation may be induced possibly through H3K27me3.	28412742
brain microvascular endothelial cell injury			BMEC	differential expression	interaction	Malat1 served as a competing endogenous RNA by sponging miR-26b and upregulating ULK2 expression	28433650
hepatocellular carcinoma		knockdown, luciferase,	HCC tissues	up-regulated	interaction	Up-regulated MALAT1 in HepG2 cells could promote cell invasion and migration, whereas knockdown of MALAT1 in HBx-expressing hepatic cells (HepG2-HBx) resulted in a markedly inhibition of cell invasion and migration both in vitro and in vivo.	28469957
photo-aging		qRT-PCR, western blot, knockdown	normal and silenced fibroblasts following irradiation with 60 mJ/cm2 ultraviolet B (UVB)	up-regulated	interaction	MALAT1 may participatein UVB-induced photo-aging via regulation of the ERK/mitogen-activated proteinkinase signaling pathway and UVB-induced MALAT1 expression is independent of ROS generation.	28487970
calcific aortic valve disease		qRT-PCR, luciferase reporter assay, RNA pull-down	human aortic valve interstitial cells (VICs).	up-regulated	interaction	MALAT1 acted as a positive regulator of osteogenic differentiation by repressing miR-204 expression and activity and thereby promoting expression of osteoblast-specific markers, including alkaline phosphatase, mineralized bone matrix formation and osteocalcin	28522163
thyroid cancer		qRT-PCR, western blot, knockdown, overexpression	Thyroid cancer tissue samples, Cancer cell line culture , Human PBMC derived macrophage preparation	up-regulated	interaction	LncRNA-MALAT1 Promotes Angiogenesis of Thyroid Cancer by Modulating Tumor-Associated Macrophage FGF2 Protein Secretion.	28543663
hepatocellular carcinoma		qRT-PCR, Luciferase reporter assays, western blot, knockdown	HCC cells	up-regulated	interaction	MALAT1 may regulate ZEB1 expression by sponging miR-143-3p and promotes hepatocellular carcinoma progression.	28543721
glioma		qRT-PCR, western blot, luciferase reporter assays	U251 and U87 cells	up-regulated	interaction	Long non-coding RNA MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101.	28551849
osteosarcoma		knockdown	human OS tissues and cell lines	up-regulated	interaction	A MALAT1/miR-509/Rac1 axis that mediates OS cell proliferation and tumor progression.	28560950
osteoarthritis		knockdown, luciferase assays	human OA chondrocyte	up-regulated	interaction	MALAT1/miR-127-5p Regulates Osteopontin (OPN)-Mediated Proliferation of Human Chondrocytes Through PI3K/Akt Pathway.	28590075
lung cancer		ChIP-seq, Luciferase activity, qRT-PCR, ChIP-PCR assays	Human lung adenocarcinoma cell line A549 and normal bronchial epithelial cell line BEAS-2B, Human lung adenocarcinoma cell line CL1–0,	up-regulated	interaction	Oct4 transcriptionally activates NEAT1 via promoter and MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.	28615056
esophageal cancer		qRT-PCR, immunofluorescence array and western blotting, dual-luciferase reporter assay	esophageal cancer cell EC-109		interaction	LncRNA MALAT1 functions as a competing endogenous RNA to regulate the expressions of ZEB1 and ZEB2 by sponging miR-200a and promotes invasion and migration of esophageal cancer cells through inducing epithelial-mesenchymal transition.	28635228
breast cancer		knockdown	breast cancer cells		interaction	The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been associated with a poorly differentiated and aggressive phenotype of mammary carcinomas. This long non-coding RNA (lncRNA) localizes to nuclear speckles, where it interacts with a subset of splicing factors and modulates their activity.	28652379
cerebral ischemic stroke		luciferase reporter assay,	experimental ischemic stroke	up-regulated	interaction	LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke conditions. However, the exact biological role of MALAT1 and its underlying mechanism in ischemic stroke remain to be elucidated.	28854438
silicosis		qRT-PCR, western blot,	fibrotic mouse lung tissues, human bronchial epithelial cells (HBE) and human lung adenocarcinoma A549 cells	down-regulated	interaction	LncRNA MALAT1 could affect the process of EMT in silica-induced pulmonary fibrosis via miR-503-PI3K/Akt/mTOR/Snail signaling pathway.	28900284
oral squamous cell carcinoma		overexpression,	oral squamous cell	up-regulated	interaction	MALAT1 can function as a competing endogenous RNA (ceRNA) to modulate STAT3 expression by absorbing miR-125b in OSCC and could be used as a novel therapeutic target in OSCC diagnosis and treatment.	28926115
osteosarcoma		luciferase assay, qRT-PCR	osteosarcoma tissues and cells	up-regulated	interaction	Lnc RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells	28938647
gastric cancer		RNA-seq, Immunohistochemistry,qRT-PCR, RNA immunoprecipitation,luciferase reporter analyses	gastric cancer and adjacent normal tissues	down-regulated	interaction	The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overexpressed in numerous cancers. However, whether MALAT1 is regulated and the related mechanisms in gastric cancer remain unclear.	28942451
choriocarcinoma			choriocarcinoma cell lines	up-regulated	interaction	The long non-coding RNA MALAT1 interacted with miR-218 modulates choriocarcinoma growth by targeting Fbxw8.	29096355
lung adenocarcinoma		ELISA, qRT-PCR	the kidney injury specimens and NRK-52E cells	differential expression	interaction	The upregulation of MALAT1 reduced the expression of miR-146a, and there was a negative linear correlation between MALAT1 and miR-146a in a RNA-induced silencing complex-dependent manner.	29115409
gastric cancer		qRT-PCR			interaction	Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer.	29162158
osteocarcinoma			osteocarcinoma (OS) cells	up-regulated	interaction	RNA binding protein Lin28A could facilitate OS cells progression by associating with the long noncoding RNA MALAT1.	29204769
non-small cell lung cancer				up-regulated	interaction	The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis.	29215698
multiple myeloma		qRT-PCR	MM samples and cell lines	up-regulated	interaction	MALAT1 was identified to function as a competitive endogenous RNA (ceRNA) for miR-509-5p to promote MM cell viability.miR-509-5p targeted the 3'-UTR of FOXP1 to suppress MM cells progression	29254219
atherosclerosis		qRT-PCR, RNA FISH, dual luciferase reporter analysis, knockdown,	macrophages	down-regulated	interaction	OxLDL induced MALAT1 transcription and MALAT1 recruits β-catenin to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages.	29258822
oxidative injury in endothelial cells		knockdown	human umbilical veendothelial cells (HUVECs)	down-regulated	interaction	Forced-expression of MALAT1 using a lentiviral vector ("LV-MALAT1") significantly attenuated H2O2-induced death and apoptosis of human umbilical vein endothelial cells (HUVECs)	29274336
osteosarcoma		qRT-PCR, gain and loss function assay	osteosarcoma tissues and cell lines	up-regulated	interaction	MALAT1 expression predicted unfavourable outcome in osteosarcoma and promoted cell proliferation through suppressing miR-205 and activating SMAD4 function	29290978
hypoxia-induced cell injury		MTT assay, Hoechst 33258 and TUNEL staining assay, JC1 vital dye	Pheochromocytoma-12 (PC12) cells	up-regulated	interaction	Role of LncRNA MALAT-1 in hypoxia-induced PC12 cell injury via regulating p38MAPK signaling pathway..	29360503
lung cancer		qRT-PCR, Dual luciferase reporter assays, western blot	atients with confirmed lung adenocarcinoma, Five lung adenocarcinoma cell lines (A549, H1299, H469, SPC-A1 and A549/DDP) and the normal human bronchial epithelium (NHBE) cell line	up-regulated	interaction	MALAT1/miR-101-3p/MCL1 signaling underlies cisplatin resistance in lung cancer	29484127
multiple myeloma		Luciferase assays, qRT-PCR, western blot	Cell Titer-Glo (CTG, Promega), BrdU Cell	down-regulated	interaction	Our findings demonstrate a crucial role of MALAT1 in the regulation of the proteasome machinery, and provide proof-of-concept that its targeting is a novel powerful option for the treatment of MM.	29487387
non-small cell lung cancer	cisplatin, DDP	qRT-PCR, western blot, immunohistochemistry,	Human lung cancer cell line A549 and the DDP-resistant cell line A549/DDP	up-regulated	interaction	Overexpression of MALAT1 contributed to the DDP resistance and might confer a potently poor prognosis.	29505924
lung adenocarcinoma		RIP, overexpression,	lung adenocarcinoma cells	up-regulated	interaction	Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1.	29575609
myocardial infarction		knockdown	the CoCl2-induced hypoxia CPC model	up-regulated	interaction	LncRNA-MALAT1 promotes CPC proliferation and migration in hypoxia by up-regulation of JMJD6 via sponging miR-125.	29605300
multiple myeloma		Overexpression, knockdown,	bone marrow plasma cells, cultured MM cell lines, murine models	up-regulated	interaction	Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma.	29632340
prostate cancer		microarray, qRT-PCR, Dual-luciferase, overexpression	prostate cancer (PCa) cells,	up-regulated	interaction	MALAT1/miR-145-5p/AKAP12 axis involved in DTX resistance of PCa cells and provided a new thought for PCa therapy.	29633510
diabetic retinopathy		knockdown, RNA immunoprecipitation, western blot,microarray	human retinal endothelial cells (HRECs), a Malat1 knockout animal model,	up-regulated	interaction	MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy.	29695738
non-small cell lung cancer		qRT-PCR, western blot, knockdown, Luciferase reporter assay,RNA immunoprecipitation	NSCLC and adjacent tissues	up-regulated	interaction	LncRNA MALAT-1 competitively regulates miR-124 to promote EMT and development of non-small-cell lung cancer.	29782349
ovarian cancer		qRT-PCR, immunohistochemistry,western blot, Luciferase reporter assay, ChIP, overexpression, knockdown,	ovarian cancer cell lines and clinical specimens	up-regulated	interaction	TGFβR2-Smad2/3-MALAT1/MARCH7/ATG7 feedback loop mediated autophagy, migration and invasion in ovarian cancer.	29794480
glioma		microarray, dual-luciferase reporter assay, qRT-PCR, western blot, knockdown, overexpression,	glioma stem cells compared with non-stem cells	up-regulated	interaction	MALAT1 enhanced glioma stem cell viability and proliferation abilities and promoted glioma tumorigenesis through suppressing miR-129 and facilitating SOX2 expressions.	29808528
diabetes mellitus		Knockdown	patients with diabetes	up-regulated	interaction	CSE inhibits insulin production by upregulating TXNIP via MALAT1-mediated downregulation of miR-17, which provides an understanding of the processes involved in the reduced β-cells function caused by cigarette smoke.	29856480
ischemia/reperfusion injury		qRT-PCR, gain and loss of function assays, overexpression, immunohistochemistry, western blot,	testicular tissues	up-regulated	interaction	LncRNA MALAT1 promotes cell apoptosis and suppresses cell proliferation in testicular IRI via miR-214 and TRPV4	29870987
ovarian cancer		luciferase reporter assay,western blot, knockdown,	OC tissues with normal specimens	up-regulated	interaction	MiR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma.	29874124
esophageal cancer		qRT-PCR, knockdown, overexpression, western blot,	TE-1 and EC109 cells	up-regulated	interaction	LncRNA MALAT1 promotes epithelial-to-mesenchymal transition of esophageal cancer through Ezh2-Notch1 signaling pathway.	29916899
lung adenocarcinoma		qRT-PCR,	A549 lung adenocarcinoma cells	up-regulated	interaction	Hypoxia exposure upregulates MALAT-1 and regulates the transcriptional activity of PTB-associated splicing factor in A549 lung adenocarcinoma cells.	29928414
diabetes mellitus		microarray, Knockdown,	organs affected by chronic diabetic complications	up-regulated	interaction	We present a novel paradigm that reveals a complex web of epigenetic mechanisms regulating glucose-induced transcription of ET-1.	29947532
colorectal cancer		knockdown, overexpression	colorectal cancer (CRC)cells	up-regulated	interaction	MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation.	29964337
clear cell renal cell carcinoma		qRT-PCR, luciferase reporter, knockdown, Overexpression, mimic	human kidney cancer tissues	up-regulated	interaction	Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression.	30037856
colon cancer		microarray, qRT-PCR, RNA-pulldown, luciferase-reporter analysis, Overexpression, Knockdown,	colon cancer (CC) cells	up-regulated	interaction	MALAT1-miR663a negative feedback loop in colon cancer cell functions through direct miRNA-lncRNA binding.	30154407
recurrent pregnancy loss		dual luciferase assay	the villus samples of 36 RPL patients.	down-regulated	interaction	Downregulated MALAT1 relates to recurrent pregnancy loss via sponging miRNAs.	30173780
hepatocellular carcinoma		qRT-PCR, dual-luciferase assay, western blot, immunohistochemistry,	HCC tissues and relative pair-matched adjacent normal liver tissues	up-regulated	interaction	MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma	30278452
colorectal cancer		microarray, dual-luciferase reporter assay, qRT-PCR, knockdown	colorectal cancer tumors and cells	up-regulated	interaction	Down-regulated MALAT1 could induce resistance of G1 phase in cell cycle, and facilitation of colorectal cancer cell apoptosis. LncRNA MALAT1 could suppress cell cycle and apoptosis through MALAT1 / miR-145 / SOX9 axis.	30285605
atherosclerosis		qRT-PCR, ELISA, western blot, Knockdown, dual luciferase	Human Coronary Artery Endothelial Cells (HCAECs)	up-regulated	interaction	The suppression of ox-LDL-induced inflammatory cytokine release and apoptosis of HCAECs by long non-coding RNA-MALAT1 via regulating microRNA-155/SOCS1 pathway.	30314869
kidney carcinoma		Dual-luciferase reporter gene assay,	KIRC tissues and adjacent normal tissues, human KIRC cell lines and normal human proximal tubular epithelial cell line.	up-regulated	interaction	LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR-194-5p/ACVR2B signaling.	30334578
breast cancer		overexpression, knockdown	human breast cancer cells	down-regulated	interaction	Long noncoding RNA MALAT1 suppresses breast cancer metastasis.	30349115
myasthenia gravis		luciferase reporter	peripheral blood mononuclear cells from MG patients and those from control subjects	down-regulated	interaction	The long noncoding RNA MALAT-1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR-338-3p in myasthenia gravis.	30362606
osteosarcoma		qRT-PCR, western blotting, dual luciferase reporter assay, RNA immunoprecipitation, Rescue experiments, overexpression, knockdown,	osteosarcoma cell	up-regulated	interaction	MALAT1 promoted OS cell viability, invasion and migration, while MALAT1 silencing exhibited opposing effects.	30365098
gastric cancer		qRT-PCR,western blot, Luciferase reporter,RNA immunoprecipitation, overexpression,	CDDP-resistant AGS(AGS/CDDP) cells and CDDP-resistant HGC-27 (HGC-27/CDDP) cells	up-regulated	interaction	LncRNA MALAT1 potentiates autophagy-associated cisplatin resistance by regulating the microRNA-30b/autophagy-related gene 5 axis in gastric cancer.	30365113
gastric cancer		qRT-PCR,western blot, immunohistochemistry, luciferase assays,rescue experiments	GC cell lines and tissues as compared with normal tissues	up-regulated	interaction	IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer.	30387833
renal cell carcinoma		qRT-PCR, western blot, luciferase reporter assay, Immunofluorescence	RCC cells	up-regulated	interaction	LncR-MALAT1 affected the proliferation and migration of RCC cells by targeting miR-22-3p through the inactivation of the PI3K/Akt signaling pathway.	30431104
osteosarcoma		qRT-PCR, Overexpression, rescue experiment, luciferase reporter,	osteosarcoma tissues , a tumor xenograft mouse model	up-regulated	interaction	MALAT1 increases stem cell-like properties by up-regulating RET via sponging miR-129-5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment	30481748
cerebral ischemia		qRT-PCR, western blot, mimic	bramicrovascular endothelial cells (BMECs)	up-regulated	interaction	MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen-Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression.	30496821
hepatocellular carcinoma		knockdown, overexpression	HCC tumor tissues	up-regulated	interaction	LncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression. Silencing of MALAT1 may be a potential approach to the treatment of HCC.	30546959
multiple sclerosis		overexpression, knockdown, RNA-seq	59 cases, 50 controls	up-regulated	interaction	Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis.	30566690
cervical cancer		Knockdown, overexpression	HeLa or SiHa cells	up-regulated	interaction	Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/microRNA-202-3p/periostin axis modulates invasion and epithelial-mesenchymal transition in human cervical cancer.	30633360
acute lymphoblastic leukemia		qRT-PCR,	Bone marrow samples from 64 cALLs, including 46 de novo and 18 relapsed patients, addition to 30 non-cancer controls	up-regulated	interaction	Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia.	30639603
prostate cancer		knockdown, overexpression,	prostate cancer cells after androgen stimulation, as well as AR	up-regulated	interaction	Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells.	30642743
breast cancer			clinical samples of breast cancertissues	up-regulated	interaction	Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer.	30683807
cutaneous squamous cell carcinoma		RNA-seq	cutaneous squamous cell carcinoma cells, xenograft models	up-regulated	interaction	MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma.	30683916
colorectal cancer	5-FU	knockdown	six CRC cell lines compared to that normal cells, HCT-116 and HCT-116/5-FU cells	up-regulated	interaction	Inhibition of MALAT1 reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer.	30716387
diabetic nephropathy	high glucose (HG)	knockdown, overexpression	renal tissues from DN patients and HG-exposed HRGECs	up-regulated	interaction	MALAT recruits methyltransferase G9a to elevate H3K9me1 and epigenetically inhibits klotho expression, and thus mediates HG-induced glomerular endothelial cell injury.	30762931
lung adenocarcinoma	docetaxel (DTX)	PCR array,	DTX-resistant LUAD cells	up-regulated	interaction	TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.	30771618
post-stroke	oxygen-glucose deprivation/reoxygenation	knockdown,	OGD/R	up-regulated	interaction	Long non-coding RNA MALAT1 regulates angiogenesis following oxygen-glucose deprivation/reoxygenation.	30784209
AIDS		RNA-Seq, knockdown,	HIV-1 infected CD4+ T cells	up-regulated	interaction	Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter.	30788509
osteosarcoma		qRT-PCR, western blot, knockdown, luciferase reporter assay,	osteosarcoma tissues	up-regulated	interaction	Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1(MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b.	30793707
colorectal cancer		In situ hybridization, qRT-PCR, knockdown, Immunohistochemistry staining,	the paraffin-embedded normal and CRC tissues.	up-regulated	interaction	MALAT1 sponges miR-106b-5p to promote the invasion and metastasis of colorectal cancer via SLAIN2 enhanced microtubules mobility.	30797712
non-small cell lung cancer		Overexpression, mimic,	NSCLC tissues and cells	up-regulated	interaction	LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis.	30841025
myocardial infarction		qRT-PCR, loss-of function assays, knockdown, rescue assay	hypoxia-induced myocardial cell	up-regulated	interaction	MALAT1-miR-200a-3p-PDCD4 axis regulated the proliferation, cell cycle progression and apoptosis of hypoxia-induced myocardial cells.	30841417
tongue squamous cell carcinoma		qRT-PCR, Luciferase reporter assay, western blot, RIP, biotin pull-down, knockdown, overexpression,	TSCC tissues and cells.	up-regulated	interaction	LncRNA MALAT1 potentiates the progression of tongue squamous cell carcinoma through regulating miR-140-5p-PAK1 pathway.	30863103
diffuse large B-cell lymphoma		knockdown, qRT-PCR, western blot, luciferase assay	Human DLBCL cell line OCI-Ly10 and DLBCL, DLBCL tissues	up-regulated	interaction	Long non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1.	30898647
rheumatoid arthritis		knockdown	synovial tissues, Fibroblast-like synoviocytes (FLSs)	down-regulated	interaction	MALAT1-driven inhibition of Wnt signal impedes proliferation and inflammation in fibroblast-like synoviocytes through CTNNB1 promoter methylation in rheumatoid arthritis.	30909750
hepatocellular carcinoma		knockdown,	HCC cell lines	down-regulated	interaction	Long Noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-mediated translation of TCF7L2.	30914432
breast invasive ductal carcinoma		mimics, luciferase reporter assay, knockdown,	patients with IDC	up-regulated	interaction	Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.	30982780
osteosarcoma		overexpression	the serum of OS patients	up-regulated	interaction	MiR-425-5p suppressed the tumorigenesis of OS via decreasing MALAT1 and TUG1 expressions through inactivation of the Wnt/β-catenin signaling pathway, contributing to a better understanding of the molecular mechanism of the tumorigenesis of OS.	30986552
atherosclerosis	ox-LDL	qRT-PCR, luciferase reporter assay, western blot, RIP, immunofluorescence analysis	human umbilical vein endothelial cells	up-regulated	interaction	Ox-LDL-induced lncRNA MALAT1 promotes autophagy in human umbilical vein endothelial cells by sponging miR-216a-5p and regulating Beclin-1 expression.	31029709
gastric cancer		knockdown, overexpression	cancer stem cells (CSCs)	up-regulated	interaction	LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability.	31037832
anaplastic thyroid carcinoma	BI-847325	qRT-PCR	ATC cell lines	down-regulated	interaction	The results showed significant downregulation of GAS5 expression and upregulation of SOX2OT in NSCLC patients compared with controls	31077090
Adrenocortical carcinoma		overexpression, knockdown	ACC cell	up-regulated	interaction	Reciprocal interplay of miR-497 and MALAT1 promotes tumourigenesis of adrenocortical cancer.	31085769
melanoma			melanoma cells and tumor specimens	up-regulated	interaction	MALAT1 regulates miR-34a expression in melanoma cells.	31101802
esophageal squamous cell carcinoma		knockdown, overexpression	ESCC cells	up-regulated	interaction	Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity.	31116509
palmitic acid (PA)-induced myocardial lipotoxic injury		qRT-PCR, ELISA, luciferase reporter assay, western blot, Knockdown	PA-treated human cardiomyocytes (AC16 cells)	up-regulated	interaction	Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis.	31123414
lung cancer	Gefitinib	qRT-PCR, western blot, luciferase reporter assay, overexpression, knockdown	A549 and HCC 1299 human lung adenocarcinoma cell lines	up-regulated	interaction	LncRNA MALAT1 Promotes Lung Cancer Proliferation and Gefitinib Resistance by Acting as a miR-200a Sponge.	31133357
hepatocellular carcinoma		knockdown, western blot, qRT-PCR	hepatocellular carcinoma tissues, cell lines	up-regulated	interaction	MALAT1 promoted cell proliferation, migration, and invasion of hepatocellular carcinoma cells by antagonizing miR-142-3p.	31168355
endometriosis		qRT-PCR, western blot, knockdown	endometrial tissues, endometrial cells	up-regulated	interaction	LncRNA MALAT1 can facilitate endometrial cell apoptosis and modulate MMP-9 expression via NF-κB/iNOS pathway, thus, mediating Ems pathogenesis.	31173276
gallbladder cancer		Microarray, knockdown,	in GBC tissues and cell lines.	up-regulated	interaction	Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.	31174563
glioma	all-trans retinoic acid(ATRA)	RIP, knockdown,	glioma cell lines	down-regulated	interaction	MALAT1, SOX2OT and ANRIL combine and crosstalk with NSPc1 in U87 cells to affect proliferation and apoptosis.	31186810
non-small cell lung cancer		qRT-PCR, dual luciferase reporter gene assay	NSCLC tissues and cells	up-regulated	interaction	LncRNA MALAT1 contributes to non-small cell lung cancer progression via modulating miR-200a-3p/programmed death-ligand 1 axis.	31240979
acute lung injury	lipopolysaccharide(LPS)	knockdown,	LPS‑treated A549 cells	up-regulated	interaction	Knockdown of the lncRNA MALAT1 alleviates lipopolysaccharide‑induced A549 cell injury by targeting the miR‑17‑5p/FOXA1 axis.	31257497
pulmonary arterial hypertension		knockdown, overexpression, Luciferase reporter assays, RNA immunoprecipitation experiments	the pulmonary arteries (PAs) and HPASMCs obtained from patients with PAH compared with adjacent normal PA tissues and HPASMCs.	up-regulated	interaction	Long non‑coding RNA MALAT1 sponges miR‑124‑3p.1/KLF5 to promote pulmonary vascular remodeling and cell cycle progression of pulmonary artery hypertension.	31257528
Ossification of the posterior longitudinal ligament		RNA-seq, qRT-PCR, knockdown, overexpression, western blot,	OPLL	up-regulated	interaction	Long non-coding RNA MALAT1 functions as miR-1 sponge to regulate Connexin 43-mediated ossification of the posterior longitudinal ligament.	31280017
sepsis		qRT-PCR, ELISA	sepsis blood samples	up-regulated	interaction	Plasma lncRNA MALAT1 expression was elevated in sepsis patients than HCs (P < 0.001)	31301104
aortic valve calcification		Knockdown, qRT-PCR, RNA pull-down, RIP, Luciferase Reporter Assay	Human aortic VICs, Aortic valve calcification patients	up-regulated	interaction	These results show the existence of a specific circuitry between MALAT1 and HuR to establish correct progression of in vitro osteogenic differentiation of VICs.	31301902
atherosclerosis	oxidized low-density lipoprotein (oxLDL)	knockdown, overexpression, RNA pull-down, RIP,	Maturation of dendritic cells, Human umbilical VECs, A mouse model of As, immature DCs	down-regulated	interaction	Loss of exosomal MALAT1 from ox-LDL-treated vascular endothelial cells induces maturation of dendritic cells in atherosclerosis development.	31305205
acut Cerebral infarction		western blot, overexpression, mimic	plasma of ACI patients	up-regulated	interaction	Long Non-Coding RNA MALAT1 Promotes Acute Cerebral Infarction Through miRNAs-Mediated hs-CRP Regulation.	31342266
Alzheimer's disease		qRT-PCR, knockdown, overexpression, western blot, Rescue experiments	primary cerebral cortex neurons of rat embryo	down-regulated	interaction	Long non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation while Stimulates Neurite Outgrowth and its Correlation with MiR-125b Mediated PTGS2,CDK5 and FOXQ1 in Alzheimer's Disease.	31345147
hepatocellular carcinoma	Hypoxia	qRT-PCR, luciferase reporter assay, knockdown	HCC cells, Hep3B cells	up-regulated	interaction	MALAT1 levels were significantly upregulated in HCC cells under hypoxia.	31347327
colorectal cancer		qRT-PCR,western blot	colorectal cancer tissues and cell lines	up-regulated	interaction	Malat1 activated autophagy and promoted cell proliferation, yet inhibited apoptosis by sponging miR-101 in colorectal cancer cells.	31372165
multiple myeloma		qRT-PCR, western blot, ELISA, luciferase reporter assay, Immunohistochemistry, overexpression	Human bone marrow stromal cell lines HS-5, Human myeloma cell lines U266, MM.1S, RPMI8226 w	up-regulated	interaction	LncRNA MALAT1 interference inhibited the proliferation and adhesion of myeloma cells by the up-regulation of miR-181a-5p through activating the Hippo-YAP signaling pathway.	31397203
hypoxia/reoxygenation-induced cell injury		qRT-PCR, RIP, dual luciferase reporter assays, Overexpression, knockdown	human umbilical vein endothelial cell	up-regulated	interaction	LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis.	31408432
hepatocellular carcinoma		qRT-PCR, western blot, Luciferase reporter assay, RIP, knockdown	HCC and paracancerous tissue, human hepatoma cell lines Huh7 and HepG2	up-regulated	interaction	MALAT1 regulates Slug through miR-124-3p, affecting HCC cell metastasis.	31466138
lung adenocarcinoma		dual-luciferase reporter assay, qRT-PCR, knockdown,mimic	chondrocytes	down-regulated	interaction	LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis.	31472145
gastric adenocarcinoma		western blot, overexpression, knockdown, qRT-PCR	serum and cell lines	up-regulated	interaction	MALAT1 promotes gastric adenocarcinoma through the MALAT1/miR-181a-5p/AKT3 axis.	31480991
prostate cancer		Luciferase reporter assays, knockdown	prostate cancer cell lines	up-regulated	interaction	Silencing of MALAT1 inhibits migration and invasion by sponging miR‑1‑3p in prostate cancer cells.	31485645
acute lung injury	LPS	knockdown,Overexpression	lung injury inflammatory model	up-regulated	interaction	Long non-coding RNA MALAT1 sponges miR-149 to promote inflammatory responses of LPS-induced acute lung injury by targeting MyD88.	31498515
periodontitis	lipopolysaccharide	qRT-PCR, luciferase reporter assay, RIP, mimic, overexpression, enzyme-linked immunosorbent assay, western blot	HGFs	up-regulated	interaction	LncRNA MALAT1 regulates inflammatory cytokine production in lipopolysaccharide-stimulated human gingival fibroblasts through sponging miR-20a and activating TLR4 pathway.	31552681
polycystic ovary syndrome		knockdown	granulosa cells	down-regulated	interaction	MALAT1 reduction was identified in GCs, which may contribute to the pathophysiological processes of PCOS by regulating TGFβ signaling through sponging miR-125b and miR-203a.	31557499
ischemia/reperfusion injury		loss- and gain-of-function, knockdown,	Human pulmonary epithelial cells, A LTIR rat model	up-regulated	interaction	Silencing of lncRNA MALAT1 Prevents Inflammatory Injury after Lung Transplant Ischemia-Reperfusion by Downregulation of IL-8 via p300.	31604167
infantile hemangioma		qRT-PCR, Luciferase reporter assays, western blot, knockdown, overexpression, IHC	the infantile skin hemangioma in the proliferative stage and involuting stage, normal subcutaneous tissues	up-regulated	interaction	MALAT1 promoted the IH progression through inhibiting miR-424 to activate MEKK3-mediated IKK/NF-κB pathway, suggesting that MALAT1, miR-424 and MEKK3 could be used as potential targets to improve IH treatment efficiency.	31610202
osteoarthritis	IL-1β	qRT-PCR,luciferase reporter assay,western blot,overexpression,knockdown	IL-1β-induced chondrocytes	up-regulated	interaction	An MALAT1/miR-145 axis contributes to ECM degradation in IL-1β-induced chondrocytes through targeting ADAMTS5, suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis.	31637891
glioblastoma		dual luciferase reporter assay,FISH, RIP,pull-down,knockdown	GBM cell, orthotopic GBM murine model.	up-regulated	interaction	Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression.	31648104
bladder cancer	cisplatin resistance		cancer cells, BC tissues	up-regulated	interaction	LncRNA-MALAT1 mediates cisplatin resistance via miR-101-3p/VEGF-C pathway in bladder cancer.	31650173
colorectal cancer		qRT-PCR,western blot,ChIP-PCR,knockdown,overexpression,luciferase reporter assay	human CRC samples, The nude mice tail vein metastasis model	up-regulated	interaction	JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway.	31665047
steroid-induced avascular necrosis of the femoral head	osteogenic medium (OM) in BMSCs and dexamethasone (DEX)	western blot,qRT-PCR,luciferase reporter assay,overexpression	SANFH tissue samples and human bone marrow stromal cells	down-regulated	interaction	Either overexpression of MALAT1 or inhibition of miR-214 improved DEX-induced inhibition of BMSC osteogenic differentiation. MALAT1 was down-regulated, while miR-214 was elevated in SANFH tissues. MALAT1 promoted osteogenesis differentiation by sponging miR-214 to upregulate ATF4.	31678133
diabetic retinopathy	Oxygen and high glucose (HG)	qRT-PCR,western blot,Knockdown,luciferase reporter assay,mimic	mouse model, DR retinal tissues,	up-regulated	interaction	MALAT1 may affect angiogenesis by sponging miR-203a-3p in DR. MALAT1 may act as a novel therapeutic target for the treatment of DR.	31689123
hepatocellular carcinoma		qRT-PCR, knockdown, western blot, Luciferase reporter assays,	HCC cells	up-regulated	interaction	Long Non-coding RNA MALAT1 Promotes Angiogenesis and Immunosuppressive Properties of HCC Cells by sponging miR-140.	31693399
asthma		knockdown, overexpression,	Airway Smooth Muscle Cells	up-regulated	interaction	Upregulation of LncRNA Malat1 Induced Proliferation and Migration of Airway Smooth Muscle Cells via miR-150-eIF4E/Akt Signaling.	31695627
pre-eclampsia		dual luciferase reporter,Western bot,knockdown, qRT-PCR, overexpression, mimics,	trophoblast cells, the placenta of patients with PE	down-regulated	interaction	MALAT1 regulates miR-206/IGF-1 axis, thereby modulating trophoblast cells migration and invasion through PI3K/Akt signal pathway.	31774373
hepatocellular carcinoma		luciferase assays,knockdown,western blot,qRT-PCR	HCC tissue	up-regulated	interaction	MALAT1 modulates FOXM1 expression via being a miR-125a-3p sponge, thus promoting HCC progression.MALAT1 knockdown disrupted proliferation and invasion,	31777593
myocardial ischemia/reperfusion injury		qRT-PCR, western blot, luciferase reporter assay	H9C2 cardiomyocytes an oxygen-glucose deprivation and reoxygenation (OGD/R) model	up-regulated	interaction	LncRNA MALAT1 promotes OGD/R-induced cardiomyocytes injury through sponging miR-20b to enhance beclin1-mediated autophagy.	31823095
sepsis	lipopolysaccharide (LPS)	knockdown	septic mice and human skeletal muscle cells of sepsis	up-regulated	interaction	lncRNA MALAT1 Accelerates Skeletal Muscle Cell Apoptosis and Inflammatory Response in Sepsis by Decreasing BRCA1 Expression by Recruiting EZH2.	31830649
non-small cell lung cancer		RIP,RNA pull-down,qRT-PCR,western blot,Luciferase reporter assays, knockdown,overexpression	NSCLC samples and cell lines	up-regulated	interaction	lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via Down-Regulating miR-202 Expression.	31863664
diabetic foot			human MSCs	down-regulated	interaction	Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p.	31866580
acute respiratory distress syndrome		qRT-PCR,overexpression,Luciferase reporter assays	peripheral blood mononuclear cells	up-regulated	interaction	Overexpression of MALAT1 Relates to Lung Injury through Sponging miR-425 and Promoting Cell Apoptosis during ARDS.	31871512
gastric cancer		western blot, immunofluorescence, qRT-PCR	GC cells	up-regulated	interaction	Long non-coding RNA MALAT1 activates autophagy and promotes cell proliferation by downregulating microRNA-204 expression in gastric cancer.	31897197
asthma		luciferase reporter gene assay, overexpression, mimic	The CD4+ T cells, blood samples	up-regulated	interaction	MALAT1 sponging miR-155 was involved with regulation of Th1/Th2 balance within CD4+ T cells	31909418
uveal melanoma		knockdown, overexpression	uveal melanoma cells	up-regulated	interaction	Suppression of Long non-coding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4.	31913701
hepatocellular carcinoma			mouse models, HCC cell lines	up-regulated	interaction	MicroRNA-3064-5p sponged by MALAT1 suppresses angiogenesis in human hepatocellular carcinoma by targeting the FOXA1/CD24/Src pathway.	31914639
gastric cancer	propofol and cisplatin	immunofluorescent staining, qRT-PCR, luciferase reporter assay, western blot, overexpression, knockdown	mice model, GC chemosensitive cells (SGC7901) and chemoresistant cells (SGC7901/CDDP)	up-regulated	interaction	Propofol facilitates cisplatin sensitivity via lncRNA MALAT1/miR-30e/ATG5 axis through suppressing autophagy in gastric cancer.	31926239
prostate cancer		qRT-PCR, western blot, Luciferase reporter assays,RIP, RNA pull-down,knockdown	Human PCa cell lines (PC-3 and DU145) , human normal prostate epithelial cell line (RWPE-1)	up-regulated	interaction	MALAT1 knockdown hindered PCa progression by regulating miR-140/BIRC6 axis in vitro and in vivo, hinting the potential value of MALAT1 in the management of PCa.	31935634
multiple myeloma		western blot, knockdown, luciferase, qRT-PCR	multiple myeloma serums and cells	up-regulated	interaction	LncRNA MALAT1 expedited MM tumorigenesis, invasion, and glycolysis via miR-1271-5p/SOX13 axis. MALAT1 might contribute to the therapy of MM as a promising indicator.	31953613
cervical cancer		luciferase activity reporter assay, qRT-PCR	CC cells	up-regulated	interaction	Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion in cervical cancer by targeting miR-625-5p and AKT2.	32009350
myocardial infarction		Knockdown, Overexpression, qRT-PCR, western blot	H9c2 cells	up-regulated	interaction	LncRNA-MALAT1 up-regulates the expression of BECN1 by binding to miR-30a, thereby increasing the level of cell autophagy after MI.	32016995
gastric cancer		overexpression, knockdown	SGC-7901 cells, BGC-823 cells	up-regulated	interaction	Silencing of MALAT1 inhibited the proliferation and promoted the apoptosis of GC cells through upregulating miR-22-3p and downregulating ErbB3.	32021298
diabetic cardiomyopathy	high-glucose	knockdown	high-glucose CFs, DCM mouse models	up-regulated	interaction	Taken together, si-MALAT1 reduces inflammation and collagen accumulation in high-glucose CFs and DCM mice via the Hippo/YAP pathway and CREB.	32069074
infantile hemangioma		qRT-PCR, dual-luciferase, western blot	IH tissues	up-regulated	interaction	Knock-down of MALAT1 inhibits the growth of HemECs through regulating miR-206/VEGFA axis, indicating that MALAT1 is a potential therapeutic mechanism for the treatment of IH.	32084582
gastric cancer	oxaliplatin	Knockdown, overexpression, qRT-PCR, western blot, RNA pull-down, RIP, Luciferase reporter assay	GC tissues and normal tumor-adjacent tissues, Normal cells (GES-1), GC cells (SGC-7901, BGC-823), and GC/OXA cells (SGC-7901/OXA and BCG-823/OXA, with lower OXA sensitivity than the corresponding GC cells), BALB/c nude mice	up-regulated	interaction	We observed a new regulatory network for MALAT1 in drug resistance of GC. MALAT1 modulates ZFP91 to promote GC cells OXA resistance via sponging miR-22-3p.	32104001
hypertension		Knockdown, Overexpression, qRT-PCR, western blot, Luciferase reporter gene assay	Han Chinese patients with essential hypertension, e Human umbilical vein endothelial cells (HUVECs), Human embryonic kidney (HEK) 293T cells	up-regulated	interaction	The G allele of MALAT1 gene rs664589 locus SNP is associated with an increased risk of hypertension. In subjects carrying the G allele, the expression of lncRNA MALAT1 in plasma is significantly decreased, resulting in an abnormally high expression of hsa-miR-539-3p and hsa-miR-485-3p, and inhibition of BMPR2 expression, which might be associated with hypertension.	32109146
cervical cancer		luciferase	HeLa cells	up-regulated	interaction	IL-6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells.	32113834
glioblastoma		knockdown	Glioblastomas cells	up-regulated	interaction	MALAT1 seems to be an important component of GBM pathogenesis	32119915
diabetes mellitus		Knockdown, qRT-PCR, western blot, luciferase reporter assays	small intestinal epithelial cells, diabetes mellitus mice	up-regulated	interaction	Knockdown of MALAT1 downregulated SOX9 expression by binding to miR‑129‑5p, thereby inhibiting the abnormal proliferation of IESCs via the WNT/β‑catenin signaling pathway.	32124944
hepatocellular carcinoma		Knockdown, qRT-PCR, western blot, ChIP, RIP, RNA pull-down, Luciferase reporter assay,	HCC specimens and matched adjacent normal tissues, HepG2, Hep3B, HuH7, and PLC/PRF5 cells	up-regulated	interaction	In conclusion, our results reveal a mechanism by which MALAT1 promotes HCC progression and provides a potential target for HCC therapy.	32129914
peripheral nerve injury		qRT-PCR	Schwann cells, mice	up-regulated	interaction	MALAT1 was enhanced after PNI and it promoted the proliferation and migration of Schwann cells through sponging miR-129-5p to increase BDNF expression and secretion.	32135165
non-small cell lung cancer		qRT-PCR, western blot, knockdown, luciferase	Non-small cell lung cancer	up-regulated	interaction	Our results demonstrated that MALAT1 contributed to NSCLC progression through the MALAT1/miR-374b-5p/SRSF7 axis.	32141554
cervical carcinoma		western blot, luciferase	cervical carcinoma tissue and dell		interaction	The regulatory effects of miR-625-5p on NF-κB and MALAT1 were interrogated by luciferase reporter assay.	32152961
glioma		Knockdown, qRT-PCR, western blot, dual-Luciferase reporter assay, RIP	glioma tissues and cells (SHG-44, LN229, HBEC-5i, 293T), nude mice	up-regulated	interaction	MALAT1 knockdown depleted migration and invasion by inhibiting autophagy through MALAT1/miR-384/GOLM1 axis in glioma in vitro and in vivo.	32196610
obstructive nephropathy			human renal proximal tubular epithelial (HK2) cells	up-regulated	interaction	m(6)A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway.	32203053
colorectal cancer		western blot, qRT-PCR	tumor cells, CRC cell lines	up-regulated	interaction	These data indicated that exosomal MALAT1 promoted the malignant behavior of CRC cells by sponging miR-26a/26b via regulating FUT4 and activating PI3K/Akt/mTOR pathway.	32209115
cerebral ischemic stroke	Oxygen glucose deprivation/re-oxygenation	Knockdown, Overexpression, qRT-PCR, western blot, Luciferase reporter assay	CIS patients, Human brain microvascular endothelial cells, rats	up-regulated	interaction	MALAT1 protected the angiogenesis function of HBMECs under OGD/R conditions by interacting with miR-205-5p/VEGFA pathway.	32217110
hepatocellular carcinoma	Sorafenib	qRT-PCR, Knockdown, Overexpression, loss/gain-of-function, Microarray, western blot, Immunofluorescence staining, Luciferase reporter assays, RNA pull-down, RIP, Immunohistochemistry,	HCC patients tissues and corresponding non-tumor liver tissues, Human HCC cell lines (HepG2, SMMC-7721), Male nude mice	up-regulated	interaction	MALAT1 may be a novel target for prognosis prediction and therapeutic strategies in patients with HCC treated with sorafenib.	32220970
hypertension		qRT-PCR, western blot, dual-luciferase reporter assay, knockdown		up-regulated	interaction	LncRNA MALAT1 regulates proliferation and apoptosis of HUVECs through the hsa-miR-124-3p/NR3C2 and/or hsa-miR-135a-5p/NR3C2 axis.	32222724
intervertebral disc degeneration		Knockdown, Overexpression, qRT-PCR, western blot, Luciferase activity, Immunofluorescent staining,	lumbar trauma patients tissues, Sprague–Dawley rats	down-regulated	interaction	Our data suggested that the MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD.	32228440
atherosclerosis		qRT‑PCR, western blot, luciferase reporter assay, knockdown	ox‑LDL‑induced macrophages	down-regulated	interaction	Knockdown of MALAT1 may promote cholesterol accumulation by regulating the miR‑17‑5p/ABCA1 axis in ox‑LDL‑induced THP‑1 macrophages.	32319624
retinoblastoma		luciferase reporter assay, RNA pull-down, knockdown, overexpression	RB tissues and cell lines	up-regulated	interaction	MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells.	32336590
papillary thyroid cancer		knockdown, luciferase assay	PTC cells	up-regulated	interaction	The microRNA miR-146b-5p can promote a MALAT1 expression by negatively regulating DNMT3A in PTC.	32343601
colorectal cancer	increasing treatments of irradiation	qRT-PCR,western blot,luciferase reporter assay, mimics	radio-resistance cells	up-regulated	interaction	MALAT1 could regulate the radio-resistance in colorectal cancer via sponging miR-101-3p.	32380053
dox-induced cardiomyopathy	doxorubicin	knockdown, luciferase assay,	human adipose-derived mesenchymal stem cells	up-regulated	interaction	LncRNA-MALAT1/miR-92a-3p/ATG4a partially mediates the cardioprotective roles of exosomeHypoxia in Dox-induced cardiac damage.	32384281
diabetic nephropathy	High glucose	Knockdown, overexpressin, qRT-PCR, western blot, Luciferase reporter assay,	Human proximal tubular epithelial cell line (HK-2)	up-regulated	interaction	MALAT1 regulated HK-2 cell pyroptosis by inhibiting miR-30c targeting for NLRP3, contributing to a better understanding of DN pathogenesis and help to find out the effective treatment for DN.	32391974
myocardial infarction	Hypoxic	RNA-seq, Knockdown, Overexpression, qRT-PCR, western blot, Luciferase reporter Assay, RNA pull-down, Immunocytochemical staining,	hPSCs (hESC line H9, WiCell),	up-regulated	interaction	hCVPC-EVs promote the infarct healing through improvement of cardiomyocyte survival and angiogenesis. The cardioprotective effects of hCVPC-EVs can be enhanced by hypoxia-conditioning of hCVPCs and are partially contributed by MALAT1 via targeting the miRNA.	32393784
bronchopulmonary dysplasia		qRT-PCR, overexpression, Luciferase reporter assays, ELISA	Alveolar epithelial cell line BEAS-2B	down-regulated	interaction	MALAT1 increased the expression of HMGB1, which contributed to inflammation as the disease progressed.	32397779
paraspeckle disintegration		Immunoprecipitation,knockdown	HeLa cell	down-regulated	mutation	Successful removal of MENepsilon/beta by a refined knockdown method resulted in paraspeckle disintegration. Furthermore, the reassembly of paraspeckles disassembled by transcriptional arrest appeared to be unsuccessful in the absence of MENepsilon/beta.	19188602
hepatocellular carcinoma		qRT-PCR, Northern blot, ISH	HCC tissue, cell line (CT26)	up-regulated	expression	Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest.	16878148
hepatocellular carcinoma		N/A	N/A	N/A	expression	HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC	17006932
endometrial stromal sarcoma		qRT-PCR, ISH	ESS tissue	up-regulated	expression	MALAT-1 gene is one of the major genes upregulated in ESS.	16441420
osteosarcoma		qRT-PCR	osteosarcoma tissue	up-regulated	N/A	The expression of MALAT-1, IMPDH2, FTL and RHOA significantly correlated with response to chemotherapy. Expression of all four genes was increased in the poor responder group that are valuable markers for the prediction of osteosarcoma therapy outcome. Especially IMPDH2 and FTL are promising candidates for the stratification of osteosarcoma patients into low- and high-risk groups. Owing to their involvement in drug action these genes may further be potential targets for the modulation of drug sensitivity.	17660802
non-small cell lung cancer		qRT-PCR	NSCLC tissue	up-regulated	expression	Increased expression of the lncRNA MALAT-1 has been observed in several types of tumors, including metastatic non-small cell lung cancer.	12970751
cervical cancer		qRT-PCR, Northern blot	cell line (CaSki)	up-regulated	expression	MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL.	20213048
lung adenocarcinoma		N/A	N/A	N/A	expression	Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro.	19690017
neuroblastoma		microarray, qRT-PCR	cell line (SK-N-SH )	down-regulated	expression	We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line.	20149803
cancer		N/A	N/A	N/A	expression	The expression of the long ncRNA MALAT1 correlates with tumor development, progression or survival in lung, liver and breast cancer.	20711585
cancer		N/A	N/A	N/A	expression	MALAT1 is a highly conserved long ncRNA originally identified as a transcript overexpressed in many cancers.	20864030
lung adenocarcinoma		qRT-PCR	cell line (A549 )	differential expression	expression	MALAT-1 is a novel class of non-coding RNA that promotes cell motility of lung adenocarcinoma cells through transcriptional and post-transcriptional regulation of motility related gene expression.	20937273
osteosarcoma		N/A	N/A	N/A	expression	Osteosarcoma patients' survival is significantly associated with MALAT-1 expression levels.	20951849
colorectal cancer		qRT-PCR	CRC tissue, cell lines (SW620, SW480 etc.)	differential expression	N/A	The 3' end of MALAT-1 is an important biological motif in the invasion and metastasis of CRC cells.	21503572
non-small cell lung cancer		N/A	N/A	N/A	expression	In NSCLC metastasizing tumors, MALAT-1 expression is three-fold higher than in non-metastasizing tumors. Furthermore, in patients with stage I disease, MALAT-1 expression is closely correlated with poor prognosis.	21550244
hepatocellular carcinoma		qRT-PCR, knockdown	HCC tissue	up-regulated	expression	Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation.	21678027
non-small cell lung cancer		N/A	N/A	N/A	expression	Specific lncRNAs can serve as predictors of tumor outcome, as shown with the expression of the lncRNA MALAT-1 in early-stage non-small cell lung cancer.	21903344
non-small cell lung cancer		qRT-PCR	cell lines (A549, plat-E, HTB-58 etc.)	up-regulated	expression	The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth.	22088988
prostate cancer		RNA-seq, qRT-PCR	prostate cancer tissue	up-regulated	N/A	Consistent with the RNA-seq results, PCA3, FR0348383 and MALAT1 overexpression was found in 80% (32/40), 72.5% (29/40), and 82.5% (33/40) of the prostate cancers respectively, whereas decreased FR0257520 expression was found in 82.5% (33/40) of the prostate cancers.	22349460
cervical cancer		qRT-PCR	cell line (CaSki)	down-regulated	N/A	Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells.	22487937
cervical cancer		qRT-PCR, Northern blot,	cell line (HeLa)	differential expression	N/A	We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells.	22491206
fibrosarcoma		qRT-PCR, Northern blot,	cell line (HT1080)	differential expression	N/A	We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells.	22491206
lung cancer		qRT-PCR, Northern blot,	cell lines (H1299, H1975 etc.)	differential expression	N/A	We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells.	22491206
breast cancer		N/A	N/A	N/A	expression	On a more mechanistic level, recent studies have revealed the contribution of lncRNAs as proto-oncogenes, e.g. GAGE6, as tumor suppressor genes, e.g. 鈥榩15 antisense RNA and lincP21' (36,91), as drivers of metastatic transformation, e.g. HOTAIR in breast cancer, and as regulators of alternative splicing, e.g. MALAT1	22492512
hepatocellular carcinoma		N/A	N/A	N/A	mutation	We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1 Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance.	22493738
bladder cancer		qRT-PCR, Western bolt, Luciferase reporter assay	bladder cancer tissue, cell line (T24)	up-regulated	N/A	We verified that MALAT-1 levels were upregulated in bladder cancer tissues compared with adjacent normal tissues, and MALAT-1 expression was remarkably increased in primary tumors that subsequently metastasized, when compared to those primary tumors that did not metastasize. levels. We further demonstrated that MALAT-1 promoted EMT by activating Wnt signaling in vitro.	22722759
non-small cell lung cancer		N/A	N/A	N/A	expression	lncRNA-associated disruption to alternative splicing has also been reported in non-small cell lung cancer by virtue of overexpression of MALAT1	22817756
small cell lung cancer		N/A	N/A	N/A	expression	For other LncRNAs, specific targets have yet to be identified. This is the case of MALAT1, a LncRNA whose expression is three times higher in metastasizing early-stage non-small cell lung cancer vs. non-metastasizing tumours	22928560
breast cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
colon cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
liver cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
lung cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
osteosarcoma		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
pancreatic cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
prostate cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
uterus cancer		N/A	N/A	N/A	expression	Sequesters SR splicing factors to regulate alternative splicing.	22996375
urothelial carcinoma of the bladder		qRT-PCR, knockdown	cell lines (T24, 5737)	up-regulated	N/A	MALAT1 was upregulated in bladder urothelial carcinoma compared with matched normal urothelium (P=.008). The MALAT1 expression levels were greater in high-grade carcinomas than in low-grade carcinoma (P=.001). The MALAT1 expression levels were greater in invasive carcinoma than in noninvasive carcinoma (P=.018). MALAT1 plays an oncogenic role in urothelial carcinoma of the bladder.	23153939
lung cancer		qRT-PCR	cell lines (A549, A549 MALAT1 KO, EBC-1 etc.)	up-regulated	expression	The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.	23243023
cancer		N/A	N/A	N/A	expression	MALAT1 (metastasis-associated lung adenocarcinoma transcript 1),another lncRNA associated with various cancers and metastasis (Ji et al. 2003; Lin et al. 2011)锛?, is found to affect the transcriptional and post-transcriptional regulation of cytoskeletal and extracellular matrix genes.	23463798
decreased myogenesis		N/A	N/A	N/A	expression	The myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis.	23485710
cancer		N/A	N/A	N/A	expression	MALAT1 is upregulated in several cancer types and its overexpression has been linked to an increase in cell proliferation and migration in lung and colorectal cancer cells.	23660942
nasopharyngeal carcinoma		qRT-PCR, Western bolt	cell lines (5-8F, 6-10B, CNE-1, CNE-2 etc.)	up-regulated	N/A	MALAT1 was highly expressed in 5-8F cells with a high metastatic potential, and lowly expressed in normal nasopharyngeal epithelium cells. Overexpression of MALAT1 by RNAa suppressed the expression of E-cadherin, promoted the expression of vimentin and enhanced the proliferation, invasion, and metastasis of CNE-1 cells.	23688988
prostate cancer		qRT-PCR, Northern bolt	prostate cancer tissue, cell lines (LNCap-AD, 22Rv1, PC-3, DU145, C4-2 etc.)	up-regulated	N/A	qPCR was used to assess the PCA3 and MALAT-1 expression levels in an additional set of 10 pairs of PCa and adjacent normal tissues. Comparing the PCA3 and MALAT-1 expression levels in the 10 paired tissue samples revealed that PCA3 and MALAT-1 were highly expressed in most of the PCa tissues. Plasma lncRNAs probably exist in the form of fragments in a stable form. MD-miniRNA enters cell culture medium at measurable levels, and MD-miniRNA derived from human PCa xenografts actually enters the circulation in vivo and can be measured to distinguish xenografted mice from controls.	23726266
prostate cancer		qRT-PCR	prostate cancer tissue, cell lines (22RV1, LNCAP-AI etc.)	up-regulated	N/A	MALAT-1 was up-regulated in human prostate cancer tissues and cell lines. Higher MALAT-1 expression correlated with high Gleason score, prostate specific antigen, tumor stage and castration resistant prostate cancer. MALAT-1 down-regulation by siRNA inhibited prostate cancer cell growth, invasion and migration, and induced castration resistant prostate cancer cell cycle arrest in the G0/G1 phases.	23845456
bladder cancer		N/A	N/A	N/A	expression	Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs	24006935
hepatocellular carcinoma		N/A	N/A	N/A	expression	Dysregulation and functional roles of lncRNAs in HCC	24183851
colorectal cancer		qRT-PCR, western blot, Luciferase reporter assay, knockdown, RIP	CRC tissue, cell lines (LoVo etc.)	up-regulated	N/A	Using in situ hybridization, we found there was higher expression of MALAT1 in the CRC than the adjacent normal colorectal tissue. We next conducted correlation analysis between MALAT1 expression and clinicopathological characteristics of CRC. A statistically significant association was observed between MALAT1 expression and extent of metastasis and invasion. In contrast to adjacent normal tissues, the MALAT1 expression in CRC tissues resected from patients with metastatic diseases was higher than those with no metastasis.	24244343
non-small cell lung cancer		qRT-PCR	NSCLC tissue	up-regulated	N/A	MALAT1 was shown to be detectable in the cellular fraction of peripheral human blood, showing different expression levels between cancer patients and cancer-free controls. For the discrimination of NSCLC patients from cancer-free controls a sensitivity of 56% was calculated conditional on a high specificity of 96%. The results of this study indicate that MALAT1 complies with key characteristics of diagnostic biomarkers, i.e., minimal invasiveness, high specificity, and robustness.	24313945
bladder cancer		N/A	N/A	N/A	expression	Oncogene	24373479
kidney cancer		N/A	N/A	N/A	expression	Oncogene	24373479
prostate cancer		N/A	N/A	N/A	expression	Putative marker	24373479
ovarian cancer		microarray, qRT-PCR	ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.)	down-regulated	N/A	The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent.	24379988
diabetes mellitus		N/A	N/A	N/A	expression	In addition, MALAT1, a conserved lncRNA, was significantly upregulated in an RF/6A cell model of hyperglycemia, in the aqueous humor samples, and in fibrovascular membranes of diabetic patients.	24436191
bladder cancer		qRT-PCR, western blot, Luciferase reporter assay, knockdown, RIP	bladder cancer tissue, cell lines (T24, RT4 etc.)	up-regulated	N/A	TGFβ1 induces malat1 expression and EMT in bladder cancer cells. malat1 overexpression is significantly correlated with poor survival in patients with bladder cancer. malat1 and E-cadherin expression is negatively correlated in vitro and in vivo. malat1 knockdown inhibits TGFβ1 induced EMT. malat1 is associated with suz12, and this association results in decrease of E-cadherin expression and increase of N-cadherin and fibronectin expression. Targeted inhibition of malat1 or suz12 suppresses the migratory and invasive properties induced by TGFβ1 We demonstrated that malat1 or suz12 knockdown inhibits tumor metastasis in animal models.	24449823
liver cancer		microarray, qRT-PCR	liver cancer tissue, cell lines (HepG2, Bel-7402, SMMC-7721, HEK-293T etc.)	differential expression	expression	Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer.	24468535
pituitary adenoma		qRT-PCR	pituitary adenomas tissue	up-regulated	expression	Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior.	24469926
breast cancer		N/A	N/A	N/A	expression	invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma	24499465
lung cancer		N/A	N/A	N/A	expression	invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma	24499465
uterus cancer		N/A	N/A	N/A	expression	invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma	24499465
breast cancer		qRT-PCR, western blot, Northern blot, knockdown	cell lines (MB231, MCF7 etc.)	up-regulated	N/A	Specifically, we looked for the changes of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1), which is found extensively and highly expressed in several kinds of tumor cells, including breast carcinoma. It was observed that proliferation, migration and invasion of breast cells were greatly affected by high concentration E2 treatment and were not affected by low concentration E2 treatment in an ERa independent way. We found that the high concentration E2 treatment largely decreased MALAT-1 RNA level. Interestingly, MALAT-1 decreasing by knocking down showed similar effects on proliferation, migration and invasion.	24525122
multiple myeloma		qRT-PCR	blood (plasma)	down-regulated	expression	HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients.	24583225
gallbladder cancer		qRT-PCR, western blot	GBC tissue, cell lines (SGC-996, NOZ)	up-regulated	expression	MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway.	24658096
lung cancer		N/A	N/A	N/A	expression	MALAT1, also known as NEAT2 (nuclear-enriched abundant transcript 2), was initially discovered as a predictive biomarker for metastasis development in lung cancer.	24667321
tumor		N/A	N/A	N/A	expression	MALAT1 plays a role in cell migration and tumor metastasis, as demonstrated by knockout of MALAT1 in lung cancer cell lines (Gutschner et al., 2013).	24721780
neuroblastoma		microarray, qRT-PCR, knockdown	cell lines (BE(2)-C, CHP134)	up-regulated	N/A	Here we demonstrated that N-Myc up-regulated the expression of JMJD1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to the JMJD1A gene promoter. Affymetrix microarray studies revealed that the gene second most significantly up-regulated by JMJD1A was MALAT1. Consistent with this finding, RT-PCR and chromatin immunoprecipitation assays showed that JMJD1A bound to the MALAT1 gene promoter and demethylated histone H3K9 at the MALAT1 gene promoter.	24742640
cancer		N/A	N/A	N/A	expression	They found that MALAT1 did not alter alternative splicing but rather actively regulated gene expression including a set of metastasis-associated genes. Consequently, MALAT1-deficient cells were impaired in migration and formed fewer tumor nodules in mouse xenograft. Antisense oligonucleotides (ASO) that block MALAT1 prevented metastasis formation after tumor implantation.	24757675
cervical cancer		N/A	N/A	N/A	expression	Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC.	24757675
hepatocellular carcinoma		N/A	N/A	N/A	expression	Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC.	24757675
lung cancer		N/A	N/A	N/A	expression	Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC.	24757675
pancreatic ductal adenocarcinoma		qRT-PCR	PADC tissue, cell lines (Panc-1, Bxpc-3, HPDE6C-7 etc.)	up-regulated	N/A	The relative level of MALAT1 was significantly higher in PDAC compared to the adjacent normal pancreatic tissues. When comparing the MALAT1 level in the cultured cell lines, remarkably higher expression of MALAT1 was found in aspc-1 PDAC cells compared with the immortal pancreatic duct epithelial cell line HPDE6c-7. Furthermore, MALAT1 expression level showed significant correlation with tumor size, tumor stage and depth of invasion. Kaplan-Meier analysis revealed that patients with higher MALAT1 expression had a poorer disease free survival.	24815433
laryngeal squamous cell carcinoma		N/A	N/A	N/A	expression	The result suggested that the MALAT1 was up-regulated in primary LSCC compared with adjacent non-cancerous tissues.	24817925
nasopharyngeal carcinoma		N/A	N/A	N/A	expression	The result found that MALAT1 was most highly expressed in 5-8F cells (high rate to be tumor and metastasis), and up-regulated in CNE-2, C666-1 and HONE-1 which is higher malignant and poorly differentiated nasopharyngeal squamous cell carcinoma, while least expressed in NP69 epithelial cells of the eternal life. The data indicated that MALAT1 might be related to the metastasis and differentiation of NPC cells.	24817925
gastric cancer		qRT-PCR, western blot, knockdown	cell lines (SGC-7901, MKN-45, SUN-16)	up-regulated	N/A	In this study, we found that MALAT1 was aberrantly highly expressed in GC cell lines (SGC-7901, MKN-45 and SUN-16), and induced specific distribution and over-expression of SF2/ASF in nucleolus. Knock-down of MALAT1 or SF2/ASF in SGC-7901 cells respectively induced significant arrest of cell cycle in G0/G1 phase along with a remarkable suppression of cell proliferation, and the nuclear distribution and expression of SF2/ASF was significantly impaired when MALAT1 was depleted. However, over-expression of SF2/ASF exhibited no effect on rescuing the cell proliferation suppression by MALAT1 depletion.	24857172
melanoma		qRT-PCR, knockdown	melanoma tissue, cell line (A-375)	up-regulated	N/A	highly expressed,can promote the metastasis of melanoma. The expression levels of UCA1 and Malat-1 lncRNAs had the potential to be prognostic indicators in metastasis of melanomas.	24892958
cervical cancer		qRT-PCR	cervical cancer tissue, cell lines (HeLa, CaSki, SiHa, HCC94 etc.)	up-regulated	N/A	In the present study, it was identified that MALAT1 expression was upregulated in cervical cancer cell lines compared with normal cervical squamous cell samples. Further study into the effect of MALAT1 on cellular phenotype revealed that MALAT1 was able to promote cell migration and proliferation. HPV correlates with MALAT1 deregulation in cervical cancer.	24932303
colorectal cancer		qRT-PCR, knockdown, RIP	cell lines (LoVo, HCT116 )	up-regulated	N/A	We found that overexpression of MALAT1 could promote cell proliferation and migration in vitro, and promote tumour growth and metastasis in nude mice. In CRC, MALAT1 could bind to SFPQ, thus releasing PTBP2 from the SFPQ/PTBP2 complex. In turn, the increased SFPQ-detached PTBP2 promoted cell proliferation and migration. SFPQ critically mediated the regulatory effects of MALAT1. Moreover, in CRC tissues, MALAT1 and PTBP2 were overexpressed, both of which were associated closely with the invasion and metastasis of CRC. MALAT1 might be a potential predictor for tumour metastasis and prognosis.Furthermore, the interaction between MALAT1 and SFPQ could be a novel therapeutic target for CRC.	25025966
colorectal cancer		qRT-PCR	colorectal cancer tissue	up-regulated	expression	The MALAT1 levels in cancerous tissues were 2.26 times higher than those measured in noncancerous tissues, and this difference was statistically significant. Based on their expression level of MALAT1, the patients were divided into a high MALAT1 expression group and a low expression group. Patients with tumours harbouring higher expression of MALAT1 showed a significantly worse prognosis with a HR of 2.863 for DFS and 3.968 for OS. Furthermore, patients with perineural invasion demonstrated significantly worse DFS and OS than those without perineural invasion.	25031737
acute myocardial infarction		N/A	N/A	N/A	N/A	Level of metastasis-associated lung adenocarcinoma transcript 1 was higher in patients with MI than in healthy volunteers (P<0.01); Patients with ST-segment-elevation MI had lower levels of metastasis-associated lung adenocarcinoma transcript 1 (P=0.005) when compared with patients with non-ST-segment-elevation	25035150
non-small cell lung cancer		microarray, qRT-PCR	tumor samples from 383 NSCLC patients	N/A	expression	Gene expression analysis of A549 adenocarcinoma cells with differential MALAT-1 lncRNA expression demonstrated an influence on the expression of Bcl-2 and its interacting proteins.	25036876
non-small cell lung cancer		qRT-PCR, western blot	NSCLC tissue, cell lines (H1915)	up-regulated	expression	We observed that the level of MALAT1 was significantly higher in brain metastasis than that of non brain metastasis samples. The level of MALAT1 was associated with patients' survival. We found that MALAT1 is increased in highly invasive subline of brain metastasis lung cancer cells. Further functional studies indicate that silencing MALAT1 inhibits highly invasive subline of brain metastasis lung cancer cell migration and metastasis by inducing epithelial-mesenchymal transition (EMT).	25217850
laryngeal squamous cell carcinoma		qRT-PCR	LSCC tissue	up-regulated	expression	We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs.	25257554
pancreatic cancer		qRT-PCR, western blot,	pancreatic cancer tissue, cell lines (BxPC-3, CFPAC-1, CAPAN-1, SW1990 etc.)	up-regulated	expression	In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro.	25269958
gastric cancer		qRT-PCR, knockdown	gastric cancer tissue, cell lines (MKN7, MKN45, MKN74, NUGC4, AZ521, AGS, KATOIII)	up-regulated	expression	Expression of both lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients. Elevated HOTAIR expression emerged both as an independent prognostic and risk factor for peritoneal dissemination. SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation, migration and invasion, but concurrently enhanced the anoikis rate in transfetced cells.	25280565
diabetes mellitus		N/A	N/A	N/A	N/A	MALAT1 expression is significantly upregulated in the retinas of STZ-induced diabetic rats and db/db mice. MALAT1 knockdown could obviously ameliorate DR in vivo, as shown by pericyte loss, capillary degeneration, microvascular leakage, and retinal inflammation. Moreover, MALAT1 knockdown could regulate retinal endothelial cell proliferation, migration, and tube formation in vitro. The crosstalk between MALAT1 and p38 MAPK signaling pathway is involved in the regulation of endothelial cell function.	25356875
multiple myeloma		qRT-PCR	Bone marrow	up-regulated	N/A	MALAT1 was overexpressed in the newly diagnosed patients compared with post-treatment patients and healthy individuals. The expression of MALAT1 strongly correlated with disease status, and the magnitude of change in MALAT1 post-treatment had prognostic relevance. The patients with early progression had a significantly smaller change in MALAT1 after treatment.	25369863
osteosarcoma		qRT-PCR, western blot, knockdown	osteosarcoma tissue, cell lines (SAOS2, MG63, U2OS)	up-regulated	expression	In our research, the MALAT1 messenger RNA (mRNA) was highly expressed in human osteosarcoma tissues, and its expression level was closely correlated with pulmonary metastasis. Knockdown of MALAT1 inhibited the proliferation and invasion of human osteosarcoma cell and suppressed its metastasis in vitro and vivo. MALAT1 might suppress the tumor growth and metastasis via PI3K/AKT signaling pathway.	25431257
colorectal cancer		microarray, qRT-PCR, western blot	CRC tissue, cell lines (HCT116, SW480, SW620, LoVo, CaCo-2 etc.)	up-regulated	expression	In the present study, we found that MALAT1 was up-regulated in human primary CRC tissues with lymph node metastasis. Knockdown of MALAT1 inhibited CRC tumor growth and metastasis. MALAT1 regulated at least 243 genes in CRC cells in a genome-wide expression profiling. Among these genes, PRKA kinase anchor protein 9 (AKAP-9) was significantly up-regulated at both mRNA and protein levels. AKAP-9 was highly expressed in CRC cells with metastatic potential and human primary CRC tissues with lymph node metastasis.	25446987
clear cell renal cell carcinoma		qRT-PCR, knockdown	ccRCC tissue, cell line (HK-2)	up-regulated	expression	The expression level of MALAT1 was higher in ccRCC tissues and renal cancer cells compared to adjacent non-tumor tissues and normal human proximal tubule epithelial cells HK-2. The ccRCC patients with higher MALAT1 expression had an advanced clinical features and a shorter overall survival time than those with lower MALAT1 expression. Additionally, our data indicated that knockdown expression of MALAT1 decreased renal cancer cell proliferation, migration, and invasion.	25480417
pancreatic cancer		qRT-PCR	pancreatic cancer tissue	up-regulated	expression	Our results indicated that lncRNA MALAT1 was highly expressed in pancreatic cancer compared with adjacent non-cancerous tissues, and positively correlated with clinical stage, tumor size, lymph node metastasis, and distant metastasis in pancreatic cancer patients. Furthermore, we also found that lncRNA MALAT1 overexpression was an unfavorable prognostic factor in pancreatic cancer patients, regardless of clinical stage, tumor size, lymph node metastasis, and distant metastasis. Finally, increased lncRNA MALAT1 expression was an independent poor prognostic factor for pancreatic patients through multivariate analysis.	25481511
colon cancer		microarray, qRT-PCR, knockdown	blood, cell lines (SW480 and SW620)	up-regulated	expression	The stimulation of colon cancer progression by TADC-derived CCL5 was associated with the up-regulation of non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), which subsequently increased the expression of Snail. Blocking MALAT-1 significantly decreased the TADC-conditioned medium and CCL5-mediated migration and invasion by decreasing the enhancement of Snail, suggesting that the MALAT-1/Snail pathway plays a critical role in TADC-mediated cancer progression	25546229
renal cell carcinoma		qRT-PCR, Luciferase reporter assay	RCC tissue	up-regulated	N/A	Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. MALAT1 expression was higher in human RCC tissues, where it was associated with reduced patient survival.	25600645
glioma		qRT-PCR	glioma tissue	up-regulated	expression	LncRNA MALAT1 expression was increased in glioma tissues compared with paired adjacent brain normal tissues. Furthermore, lncRNA MALAT1 was associated significantly with WHO grade (I-II vs. III-IV; P = 0.007) and tumor size. Moreover, the level of lncRNA MALAT1 expression was markedly correlated with the glioma patients' overall survival. Multivariate analysis suggested that increased lncRNA MALAT1 expression was a poor independent prognostic predictor for glioma patients.	25613066
esophageal squamous cell carcinoma		qRT-PCR, western blot, knockdown	ESCC tissue, cell lines (EC109, EC9706, KYSE150, KYSE450)	up-regulated	expression	MALAT1 was over-expressed in 46.3% of ESCC tissues, mostly in the high-stage tumor samples. Enhanced MALAT1 expression levels were positively correlated with clinical stages, primary tumor size, and lymph node metastasis. Inhibition of MALAT1 suppressed tumor proliferation in vitro and in vivo, as well as the migratory and invasive capacity.MALAT1 serves as an oncogene in ESCC, and it regulates ESCC growth by modifying the ATM-CHK2 pathway.	25613496
glioblastoma		N/A	N/A	N/A	N/A	Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.	25772239
pancreatic cancer		qRT-PCR, western blot	cell lines (AsPC-1, CFPAC-1)	up-regulated	expression	In this study, our data showed that MALAT-1 could increase the proportion of pancreatic CSCs, maintain self-renewing capacity, decrease the chemosensitivity to anticancer drugs, and accelerate tumor angiogenesis in vitro. In addition, subcutaneous nude mouse xenografts revealed that MALAT-1 could promote tumorigenicity of pancreatic cancer cells in vivo. The underlying mechanisms may involve in increased expression of self-renewal related factors Sox2.	25811929
triple-negative breast cancer		microarray, qRT-PCR	triple-negative breast cancer tissue	up-regulated	expression	We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC.	25996380
papillary thyroid carcinoma		microarray, qRT-PCR	papillary thyroid carcinoma tissue	down-regulated	expression	Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion.	25997963
gastric cancer		qRT-PCR	gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.)	up-regulated	expression	All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues.	26096073
non-small cell lung cancer			non-small cell lung cancer and pancreatic cancer	up-regulated	expression	From subgroup analyses,we present evidence that lncRNA MALAT1 overexpression was an unfavorable prognostic factor for patients' overall survival in non-small cell lung cancer and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and 1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a potential prognostic factor in human cancers.	26131129
pancreatic cancer			non-small cell lung cancer and pancreatic cancer	up-regulated	expression	From subgroup analyses,we present evidence that lncRNA MALAT1 overexpression was an unfavorable prognostic factor for patients' overall survival in non-small cell lung cancer and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and 1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a potential prognostic factor in human cancers.	26131129
lung cancer		qRT-PCR	blood	down-regulated	expression	The expression of MALAT1 in the whole blood of lung cancer patients with metastasis was stronger compared to non-metastasis, which showed that MALAT1 promotes the tumor metastasis and additionally, the whole blood with lymph node metastasis represented a lower expression of MALAT1 compared to bone or brain metastasis.	26137228
breast cancer		qRT-PCR	breast cancer and adjacent non-cancerous specimens, cell lines (MDA-MB-231 and MDA-MB-453)	down-regulated	expression	We found that MALAT1 was downregulated in breast tumor cell lines and cancer tissue, and showed that knockdown of MALAT1 in breast cancer cell lines induced an epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3 kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer patients was associated with shorter relapse-free survival	26191181
proliferative vitreoretinopathy		Microarray, qRT-PCR	biofluid of PVR (Proliferative VitreoRetinopathy) patients	up-regulated	expression	MALAT1 was significantly up-regulated in the cellular and plasma fraction of peripheral blood in PVR patients. In vitro experiments revealed the role of MALAT1 in regulating RPE proliferation and migration, which is critical for ERMs formation. MALAT1 is a potential prognostic indicator and a target for the diagnosis and gene therapy for PVR diseases.	26241674
cervical cancer		qRT-PCR, western blot, Luciferase reporter assay, knockdown,	HR-HPV+ cervical cancer tisssue, cell lines (HeLa, CaSki, SiHa)	up-regulated	expression	Findings of this study confirmed higher MALAT1 expression in HR-HPV (+) cervical cancer. Knockdown of endogenous MALAT1 significantly reduced cell growth rate and invasion and increased cell apoptosis of Hela and siHa cells. Besides, knockdown of MALAT1 increased the expression of miRNA-124, while ectopic expression of miR-124 decreased MALAT1 expression. MALAT1 can indirectly modulate GRB2 expression via competing miR-124. Knockdown of GRB2 reduced cell invasion and increased cell apoptosis. In conclusion, MALAT1 can promote HR-HPV (+) cancer cell growth and invasion at least partially through the MALAT1-miR-124-RBG2 axis.	26242259
cervical cancer		qRT-PCR, knockdown	Tumor and adjacent normal tissues, cervical cancer cell lines(HeLa, CaSki)	up-regulated	expression	MALAT1 expression is significantly increased in cervical cancer than in normal tissues. Its expression in the cancerous tissues is also significantly higher than in adjacent normal tissues. MALAT1 expression is correlated with tumor size, FIGO stage, vascular invasion and lymph nodes metastasis and is an independent predictor for overall survival of cervical cancer. When endogenous MALAT1 was knocked down, the cancer cells had significantly reduced proliferation and invasion and increased apoptosis	26400521
esophageal squamous cell carcinoma		qRT-PCR	ESCC tissue	up-regulated	expression	MALAT1 expression was increased in ESCC tissue than in adjacent normal tissue samples (P< 0.001). MALAT1 level was positively related to pT stage (P= 0.01).	26406400
lung cancer		knockdown	human bronchial epithelial (HBE) cells	up-regulated	expression	Cigarette smoke extract (CSE) caused decreases of miR-217 levels and increases in lncRNA MALAT1 levels. The CSE-induced increase of MALAT1 expression was blocked by an miR-217 mimic, indicating that miR-217 negatively regulates MALAT1 expression.	26415832
esophageal squamous cell carcinoma		qRT-PCR, knockdown	esophageal squamous cell carcinoma and adjacent nonneoplastic tissues, cell lines(TE1, KYSE30, KYSE70, KYSE150, KYSE270, KYSE410, EC9706)	up-regulated	expression	Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase	26493997
oral squamous cell carcinoma		qRT-PCR, western blot, knockdown	OSCC tissue, cell lines (Tscca, Tca8113P160, Tca8113, Hep-2)	up-regulated	expression	We found that MALAT1 is overexpressed in OSCC tissues compared to normal oral mucosa by real-time PCR. MALAT1 served as a new prognostic factor in OSCC patients. When knockdown by small interfering RNA (siRNA) in OSCC cell lines TSCCA and Tca8113, MALAT1 was shown to be required for maintaining epithelial-mesenchymal transition (EMT) mediated cell migration and invasion. Western blot and immunofluorescence staining showed that MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro. Meanwhile, both nucleus and cytoplasm levels of β-catenin and NF-B were attenuated, while elevated MALAT1 level triggered the expression of β-catenin and NF-B. More importantly, targeting MALAT1 inhibited TSCCA cell-induced xenograft tumor growth in vivo.	26522444
osteosarcoma		qRT-PCR, knockdown	osteosarcoma tissue, cell lines (MG63, Saos-2, hFOB1.19, MNNG/HOS)	up-regulated	expression	We observed that MALAT1 expression was up-regulated in human osteosarcoma cell lines and tissues. In vitro knockdown of MALAT1 by siRNA significantly inhibited cell proliferation and migration, and induced cell cycle arrest and apoptosis in osteosarcoma cells. In addition, MALAT1 knockdown markedly suppressed the formation of tubular network structures and caused breakage of stress fibers in osteosarcoma cell lines U2OS and MNNG/HOS.	26575981
glioma		microarray, qRT-PCR, western blot, knockdown	cell line SHG139S	down-regulated	expression	Our results showed that downregulation of MALAT1 suppressed the expression of Sox2 and Nestin which are related to stemness, while downregulation of MALAT1 promoted the proliferation in SHG139S. Further research on the underlying mechanism showed that the effects of MALAT1 downregulation on SHG139S were through regulating ERK/MAPk signaling activity. And we also found that downregulation of MALAT1 could activate ERK/MAPK signaling and promoted proliferation in SHG139 cells.	26649728
breast cancer		qRT-PCR, western blot, Luciferase reporter assays, RIP	breast cancer specimens and adjacent normal breast tissue	up-regulated	expression	We reported that MALAT1 was upregulated in triple-negative breast cancer (TNBC) tissues. Knockdown of MALAT1 inhibited proliferation, motility, and increased apoptosis in vitro. In vivo study indicated that knockdown of MALAT1 inhibited tumor growth and metastasis. Patients with high MALAT1 expression had poorer overall survival time than those with low MALAT1 expression. In addition, our findings demonstrate a reciprocal negative control relationship between MALAT1 and miR-1: downregulation of MALAT1 increased expression of microRNA-1 (miR-1), while overexpression of miR-1 decreased MALAT1 expression. Slug was identified as a direct target of miR-1.	26676637
pre-eclampsia		knockdown	placentas from the patients with preeclampsia, EG-3 trophoblast cell line	down-regulated	expression	Silencing of MALAT-1 in JEG-3 cells suppressed proliferation and induced cell cycle arrest at G0/G1 phase. The migration rate and the invasiveness of JEG-3 cells were suppressed when MALAT-1 was downregulated. MALAT-1 may play an important role in the regulation of proliferation, cell cycle, apoptosis, migration and invasion of trophoblast cells, and under-expression of MALAT-1 during early placentation may be involved in the pathogenesis of preeclampsia.	26722461
cervical cancer		Microarray, knockdown, qRT-PCR, western blot, immunofluorescence	cervical cancer (CC) cells and tissues	up-regulated	expression	The down-regulation of MALAT1 by shRNA in CC cells inhibited the invasion and metastasis in vitro and in vivo. MALAT1 functions to promote cervical cancer invasion and metastasis via induction of EMT, and it may be a target for the prevention and therapy of cervical cancers.	26798987
triple-negative breast cancer		microarray, immunoblotting, qRT-PCR, loss and gain of gene	MDA-MB-231 cells	up-regulated	N/A	N/A	26917489
breast cancer		N/A	breast cancer cells	up-regulated	N/A	MALAT1 induced migration and invasion of breast cancer	26926567
esophageal squamous cell carcinoma		qRT-PCR	106 paired ESCC tissues	down-regulated	N/A	MALAT1 decreased tumor formation and improved survival	27015363
glioma		qRT-PCR, knockdown,	glioma tissues compared with that of paracancerous tissues	up-regulated	expression	Silencing of Long Non-Coding RNA MALAT1 Promotes Apoptosis of Glioma Cells.	27134488
Cervical Cancer		qRT-PCR	the Cervicovaginal Lavage Samples of Cervical Cancer Patients	Differentially Expressed	expression	Exosomal Long Noncoding RNAs are Differentially Expressed in the Cervicovaginal Lavage Samples of Cervical Cancer Patients.	27184657
breast cancer		overexpression	breast cancer samples	up-regulated	expression	MALAT1 overexpression was also associated with poor RFS in tamoxifen treated ER-positive breast cancer patients, which might serve as a potential biomarker to predict endocrine treatment sensitivity.	27191888
ovarian cancer		Overexpression, microarray, qRT-PCR, western blotting, knockdown	37 normal ovarian tissues and 45 ovarian cancer tissues	up-regulated	expression	MALAT-1 is highly expressed in ovarian tumors. MALAT-1 promotes the growth and migration of ovarian cancer cells, suggesting that MALAT-1 may be an important contributor to ovarian cancer development.	27227769
gastric cancer		overexpression, knockdown, ChIP	GC tissues and three cell lines	up-regulated	expression	Up-regulated MALAT1 promoted the invasion and metastasis of GC, and the increase of EGFL7 expression was a potential mechanism via altering its H3 histone acetylation level.	27259812
ovarian cancer		knockdown, microarray, qRT-PCR,	nude mice ovarian cancer SKOV3 cell line.	up-regulated	expression	MALAT1 inhibition significantly suppressed tumorigenity in vitro and in vivo (P<0.01).	27313681
oral tongue squamous cell carcinoma		qRT-PCR	oral tongue squamous cell	up-regulated	expression	Upregulated MALAT1 in TSCC promoted EMT and inhibited cell apoptosis by modulating Wnt/β-catenin signaling pathway.	27353727
non-small cell lung cancer		qRT-PCR, knockdown,	NSCLC tissues with/without bone metastasis and NSCLC cell lines with (ACC-LC-319/bone2)/without (SPC-A1) bone metastatic ability	up-regulated	expression	MALAT1 was significantly highly expressed in NSCLC tissues with bone metastasis and in NSCLC cell lines with high bone metastatic ability. Downregulation of MALAT1 expression significantly inhibited proliferation and induced cell apoptosis in comparing with the negative controls.	27431200
epithelial ovarian cancer		qRT-PCR, overexpression	the EOC/DM group compared with the EOC/NDM and HC groups	up-regulated	expression	The levels of plasma MALAT1 may act as a valuable biomarker for the diagnosis of metastasis.	27446438
breast cancer		knockdown, qRT-PCR	tissues and serum of Breast Cancer	up-regulated	expression	MALAT1 upregulation plays an important rolein BC development, and serum MALAT1 level may be a potential tumor marker for BC diagnosis	27466303
esophageal cancer		qRT-PCR	esophageal cancer patients	up-regulated	expression	MALAT1 expression was tightly related to lymphatic invasion (P=0.018), distant metastasis (P=0.033) and tumor differentiation (P=0.025), but shared no association with age, gender and tumor location (P>0.05).	27470544
osteosarcoma		qRT-PCR, Immunofluorescence stain, western blot, knockdown	osteosarcoma tissue, paired adjacent noncancerous tissue	up-regulated	expression	MALAT1 significantly reduced the expression of β-catenin, MMP7, and c-MYC in U-2OS cells.	27510783
osteosarcoma		qRT-PCR,	osteosarcoma tissues compared with paired non-tumor tissues	up-regulated	expression	MALAT1 was significantly up-regulated in osteosarcoma tissues. The expression of MALAT1 was remarkably associated with advanced clinical stage and distant metastasis of osteosarcoma patients. osteosarcoma patients with higher levels of MALAT1 had a shorter survival time.	27649655
uveal melanoma		Knockdown	uveal melanoma tissues and normal tissues	up-regulated	expression	Knockdown of MALAT1 suppressed uveal melanoma cell proliferation, colony information, invasion and migration.	27725873
bladder cancer		qRT-PCR	80 BC and matched adjacent normal tissues, 240 serum samples	up-regulated	expression	The differentially expressed lncRNAs were then analyzed in 240 serum samples (training set) and three lncRNAs (MEG3, SNHG16 and MALAT1) showed differential expression.	27793008
hepatocellular carcinoma		Knockdown	HCCA tissues and cell lines		expression	LncRNA-MALAT1 was specifically upregulated in HCCA tissues and cell lines, and was associated with pathological T stage, a larger tumor size, and perineural invasion. Knockdown of MALAT1 inhibited the proliferation, migration, and invasion of human HCCA cell.	28059437
cervical cancer		western blot	HeLa cells	up-regulated	expression	The low expression of miRNA-143 and high expression of MALAT1 in cervical cancer cells could possibly potentiate cell invasion/migration and alter the levels of vimentin and E-cadherin.	28252165
lung adenocarcinoma		TaqMan assay			expression	The lncRNA MALAT1 was associated with a better survival for advanced lung adenocarcinoma patients, which may offer a novel prognostic biomarker for this patient subgroup.	28253859
gastric cancer		qRT-PCR, knockdown	GC cell lines and tissues	differential expression	expression	MALAT-1 may promote the migration and invasion of GC cells in part by regulating EMT.	28276823
diffuse large B-cell lymphoma		qRT-PCR, western blotting	Human normal B lymphocytes (IM-9I) and DLBCL cell lines, a subcutaneous tumor xenograft model nude mice	up-regulated	expression	Inhibiting lncRNA MALAT-1 can improve the chemotherapy sensitivity of DLBCL by enhancing autophagy-related proteins.	28292022
osteosarcoma		Knockdown		down-regulated	expression	MALAT1 was significantly increased in osteosarcoma specimens and cell lines	28388584
brain vascular dysfunction		knockdown, overexpression	Primary human bramicrovascular endothelial cells		expression	LncRNA MALAT1 may protect human brain vascular endothelial cells from OGD-R-induced apoptosis via a PI3K-dependent mechanism.	28413461
nasopharyngeal carcinoma		qRT-PCR	NPC cells and serum samples , 101 NPC patients, 20 patients with chronic nasopharyngitis (CN), 20 EBV carriers (EC) and 101 healthy controls	up-regulated	expression	High levels of these three lncRNAs were closely related to advanced NPC tumor node metastasis stages and EBV infection. Serum levels of these three lncRNAs declined significantly in patients after therapy.	28467811
neuroblastoma			metastatic neuroblastoma tissues		expression	LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma.	28468579
ovarian cancer		Knockdown	human ovarian epithelial cell line (HOSE) and OC cell lines (ES-2, OVCAR3, SKOV3 and HO8910)	up-regulated	expression	Upregulation of MALAT1 in OC may facilitate tumorigenesis and metastasis. Knockdown of MALAT1 expression has potential as a novel target for the diagnosis and therapy of OC.	28587379
cholangiocarcinoma		qRT-PCR,	cholangiocarcinoma cells	up-regulated	expression	MALAT1 promoted cholangiocarcinoma cell proliferation and invasion	28592124
non-small cell lung cancer		knockdown	the exosomes from healthy subjects and NSCLC patients	up-regulated	expression/mutation	Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis.	28623135
bladder cancer		in situ hybridization (ISH), qRT-PCR	bladder cancer tissues		expression	High MALAT1 expression was associated with advanced histological grade, high tumor stage, and positive lymph nodes.	28648755
multiple myeloma		knockdown	MM cell		expression	MALAT1 was found to be highly expressed in RPMI8226 and U266 cells. Down-regulation of MALAT1 via RNA interference significantly inhibited the proliferation of MM cells through cell cycle arrest at G1 phase.	28664617
glioblastoma	Temozolomide	qRT-PCR, western blot	the U251/TMZ and U87/TMZ cell	up-regulated	expression	MALAT1 has been reported to be closely related to tumor biology	28668966
breast cancer			breast cancer tissues and cell lines	up-regulated	expression	MALAT1 promoted cancer cell invasion through inducing epithelial-mesenchymal transition	28675122
pancreatic ductal adenocarcinoma		knockdown	tumourigenesis			Play an important role in tumourigenesis	28701723
acute monocytic leukemia		qRT-PCR, knockdown, western blot	patients with acute monocytic leukemia (M5) compared with healthy controls	up-regulated	expression	Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long non-coding RNA, has been documented to be a new prognostic marker and gene regulator in several types of cancer, but its potential involvement in acute myeloid leukemia (AML) remains unclear.	28713913
hepatocellular carcinoma		qRT-PCR, luciferase reporter assay, RNA-binding protein immunoprecipitation, RNA pull-down	sh-MALAT1 HepG2 cell and 15 hepatocellular carcinoma tissues	differential expression	expression	MALAT1 stimulates hepatocellular carcinoma progression and justifies targeting metastasis-associated lung adenocarcinoma transcript 1	28720061
epithelial ovarian cancer			64 samples of surgical EOC tissues and 30 samples of normal ovarian tissues	down-regulated	expression	Plays a key role in the malignant phenotype of tumors.abnormal regulation of lncRNA MALAT1 impacts clinical prognostic and tumor metastasis	28770968
glioma		qRT-PCR, western blot	glioma tissues		expression	We found that Malat1 expression and autophagy activity were significantly increased in glioma tissues compared with adjacent normal tissues.	28834690
nasopharyngeal carcinoma		qRT-PCR, western blot, luciferase reporter assay, knockdown	MALAT1, miR-124 and Capn4 mRNA NPC cell lines	up-regulated	expression/mutation	Long non-coding RNA MALAT1 (Metastasis-associated lung Adenocarcinoma transcript-1) has been demonstrated to play a critical role in the regulation of cancer progression and metastasis. However, little is known about MALAT1 in nasopharyngeal carcinoma (NPC) pathogenesis and progression.	28857668
ovarian cancer		qRT-PCR	Ovarian Cancer tissues, adjacent normal tissue and normal human ovarian surface epithelial cells (HOSEPiCs)	down-regulated	expression	Results of this study indicated that lncRNA MALAT1 is a oncogene in ovarian cancer, involved in the regulation of cell viability, migration and invasion abilities of ovarian cancer cells, which achieved its biological function by regulating miR-200c expression.	28899458
triple-negative breast cancer		qRT-PCR	TNBC tissues and paired adjacent non-tumor tissues	up-regulated	expression	Function assay showed that MALAT1 silencing significantly decreased cell proliferation, migration, and invasion.	28915533
breast cancer	insulin	qRT-PCR, RNA pull-down, RIP, Co-IP, western blot,	N/A			MALAT1 binding competes with the interaction between sirtuin1 (SIRT1) and DBC1, which then releases SIRT1 and enhances its deacetylation activity.	28973437
fatty liver disease		RNA-seq	normal tissue and lobular inflammation and fibrosis samples	up-regulated	expression	MALAT1 expression may contribute to the development of fibrosis in NASH through mechanisms involving inflammatory chemokines.	28993096
gallbladder cancer		qRT-PCR,	GBC tissues and adjacent normal tissues	up-regulated	expression	LncRNA MALAT1 can be considered as an indicator for evaluating the recurrence, metastasis, and prognosis of GBC patients. We also demonstrate how the overexpression of MALAT1 confers an oncogenic function in GBC.	29058818
retinoblastoma					expression	MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation.	29073720
gestational diabetes mellitus		qRT-PCR	the patients with GDM correlated with both lncRNA p21 (r=0.333, P=0.018) and lncRNA H19 (r=0.314, P=0.030).		expression	The expression level of lncRNA MALAT1 was higher among the cases than the controls (P=0.007). Expression of lncRNA MALAT1 could offer a novel biomarker to predict GDM.	29110299
breast cancer		qRT-PCR			expression	Genetic variants of lncRNA MALAT1 were associated with the susceptibility of BC, and meaningful genetic alteration might affect the corresponding mRNA expression of lncRNA MALAT1.	29146194
bladder cancer		qRT-PCR, CRISPR-based technologies			expression	LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells.	29151968
colorectal cancer			colorectal cancer tissue		expression	Confirmation studies with large sample size and further mechanistic investigations into the function of MALAT1 and its genetic variants are warranted to advance our understanding of their roles in colorectal carcinogenesis, and to aid in the development of novel and targeted therapeutic strategies.	29190941
glioblastoma multiforme			Human GBM cell lines	up-regulated	expression	ANRIL is upregulated in osteosarcoma tissues, and may promote the proliferation and metastasis of osteosarcoma cells.	29202181
osteosarcoma			well-accepted cell line of human OS,		expression	Targeting the long noncoding RNA MALAT1 blocks the pro-angiogenic effects of osteosarcoma and suppresses tumour growth.	29209144
lung cancer					expression	MALAT1 acted as a competing endogenous RNA to upregulate SOX9 expression by sponging miR-101 in DDP-resistant cancer cells, through Wnt signaling pathway.	29212230
pancreatic cancer		qRT-PCR, western blot,	PC tissues and cells		expression	Long noncoding RNA MALAT1 affecting pancreatic cancer by regulating Hippo-YAP signaling.	29215734
colon cancer			colon cancer cell lines	up-regulated	expression	MALAT1 may serve as a competing endogenous lncRNA (ceRNA) to mediate HMGB1 by sponging miR-129-5p in colon cancer.high motility group box protein 1 (HMGB1), was predicted as a mRNA target of miR-129-5p	29226325
osteosarcoma		knockdown	osteosarcoma cells	down-regulated	expression	MALAT1 could inhibit the expression of E-cadherin and promote the expression of β-catenin	29290771
breast cancer		qRT-PCR, chemiluminescence immunoassay,	80 patients with breast cancer, 80 controls	up-regulated	expression	MALAT1 expression was significantly elevated in breast cancer cases compared to controls, In conclusion, MALAT1 expression level was positively correlated with lymph node status, estrogen receptor (ER), tumor stage and histological grade indicating its possible rognostic value.	29310836
colorectal cancer		knockdown	human CRC cell line	down-regulated	expression	We investigated the clinical role of MALAT1 and found that high lncRNA MALAT1 expression level is associated with poor prognosis in CRC patients receiving oxymatrine treatment (P<0.01). In conclusion, we demonstrate that lncRNA MALAT1 is a stimulator for oxymatrine resistance in CRC and it may provide therapeutic and prognostic information for CRC patients.	29328404
breast cancer		qRT-PCR	breast cancer tissues	up-regulated	expression	Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer.	29386907
pancreatic cancer			Panc1 cells and other pancreatic cancer cell lines	down-regulated	expression	Analysis of changes in gene expression after MALAT-1 knockdown shows that this lncRNA represses several tumor suppressor-like genes including N-myc downregulated gene-1 (NDRG-1), a tumor suppressor in pancreatic cancer that is also corepressed by EZH2 (a PRC2 complex member).	29389953
ischemia/reperfusion injury						LncRNA MALAT1 sponges miR-133 to promote NLRP3 inflammasome expression in ischemia-reperfusion injured heart.	29407129
non-small cell lung cancer		qRT-PCR, western blot	A549, SPC-A-1 and NCI-H460 cells	down-regulated	expression	Downregulation of MALAT1 may promote apoptosis and suppress proliferation, migration and invasion of human NSCLC A549 cells by inhibiting autophagy, thereby suppressing the development of NSCLC.	29439314
glioblastoma		qRT-PCR, western blot	The human GBM cell line U251	up-regulated	expression	Our study indicates that knockdown of MALAT1 reverses chemoresistance to TMZ via promoting miR-101 regulatory network in GBM and thus offers a novel prognostic marker and potential target for GBM TMZ-based chemotherapy.	29479863
ovarian cancer		knockdown	ovarian cancer cells	up-regulated	expression	Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway.	29548748
hepatocellular carcinoma		qRT-PCR, overexpression	patients with HCC	up-regulated	expression	MALAT1 might represent a putative non-invasive prognostic biomarker indicating worse liver failure score in HCV-related HCC patients with traditional markers. Large-scale verification is warranted in future studies.	29604585
ovarian cancer		qRT-PCR, dual-luciferase reporter assays, knockdown, overexpression,	n ovarian cancer tissues and EOC cell lines.	up-regulated	expression	MALAT1 was overexpressed in EOC. Silencing of MALAT1 decreased EOC cell viability and inhibited EOC cell migration and invasion. These data revealed that MALAT1 may serve as a new therapeutic target of human EOC.	29693187
lung cancer-associated malignant pleural effusion		qRT-PCR	LC-MPE	up-regulated	expression	Combination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer.	29731641
cutaneous squamous cell carcinoma		qRT-PCR, knockdown	Fifty-five tissue samples of CSCC and 10 normal epidermal tissues	up-regulated	expression	The long noncoding RNA MALAT1 promotes the occurrence and progression of CSCC and can potentially serve as a therapeutic target in treatment of CSCC.	29735442
bladder transitional cell carcinoma		qRT-PCR, overexpression, luciferase assay	BTCC cells	up-regulated	expression	This ceRNA regulatory network concerning MALAT1 and the positive MALAT1/foxq1 correlation benefit a better understanding of BTCC pathogenesis and promote the feasibility of lncRNA-directed therapy against this disease.	29736319
cardiovascular disease		qRT-PCR, western blot, ELISA	oxLDL-treated human umbilical veendothelial cells.	up-regulated	expression	The results of the present study revealed a novel mechanism underlying the onset of atherogenesis associated with endothelial cells and macrophages: Exosomal MALAT1 derived from oxLDL-treated endothelial cells promoted M2 macrophage polarization.	29750307
non-small cell lung cancer		knockdown, qRT-PCR,	NSCLC tumor tissues and adjacent non-cancerous tissues from 120 patients with NSCLC	up-regulated	expression	MALAT1 expression was significantly increased in NSCLC tissues and was revealed to serve a role in the progression of NSCLC.	29805668
breast cancer		qRT-PCR,	tumor samples of 509 breast cancer patients	up-regulated	expression	High expression of lncRNA MALAT1 is associated with breast cancer relapse and may play a role in tumor progression.	29845475
nonalcoholic fatty liver disease			patients with nonalcoholic steatohepatitis compared to those diagnosed with simple steatosis	up-regulated	expression	Metastasis-associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune-mediated liver damage.	29881817
breast cancer		microarray, knockdown,	cells ectopically expressing Nischarcompared to control cancer cells, a breast cancer cell model	up-regulated	expression	Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.	29912916
non-small cell lung cancer		qRT-PCR, western blot, Dual luciferase reporter assay	A cohort of 36 NSCLC tumor tissues and adjacent normal tissues	up-regulated	expression	LncRNA MALAT1 promotes migration and invasion of NSCLC by targeting miR-206 and activating Akt/mTOR signaling.	29916897
diabetic cataract		qRT-PCR, knockdown, overexpression, western blot, Chromatin immunoprecipitation and Dual luciferase assay,	human lens epithelial cells (HLECs)	up-regulated	expression	HG induced the up-regulation of MALAT1 in HLECs via SP1 binding MALAT1, which promoted the the apoptosis and oxidative stress of HLECs through the activation of p38MAPK signaling pathway.	29936249
Thyroid cancer		knockdown	an EMT model and a CSC model		expression	The exosomes from the CSC model also transferred the lncRNA MALAT1 and the transcription factors SLUG and SOX2 but additionally transferred linc-ROR and induced EMT in the normal thyroid cells.	29967342
papillary thyroid carcinoma		qRT-PCR,	PTC tissues compared with paired corresponding noncancerous tissues	up-regulated	expression	MALAT1 may exert oncogenic function in PTC and may be a potential diagnostic marker for this cancer.	29987950
traumatic brain injury		RNA-Seq	rats treated with exosomes	differential expression	expression	MALAT1 in hASC-derived exosomes modulates multiple therapeutic targets, including inflammation, and has tremendous therapeutic potential for treatment of TBI.	30001722
osteosarcoma		luciferase reporter assay, RNA binding protein immunoprecipitation, RNA pull-down, overexpression, knockdown, mimics,	human osteosarcoma cells including MG63, Saos-2, U2OS, and KHOS compared with human osteoblast cell line hFOB 1.19.	up-regulated	expression	MALAT1 induces osteosarcoma progression by targeting miR-206/CDK9 axis.	30076726
head and neck squamous cell carcinoma		overexpression, ChIP, luciferase reporter,		up-regulated	expression	TGF-β-induced STAT3 overexpression promotes human head and neck squamous cell carcinoma invasion and metastasis through malat1/miR-30a interactions.	30118844
breast cancer		qRT-PCR	BC tissues, normal tissues, MDA-MB-231 and MCF7 cell lines	up-regulated	expression	MALAT1, GAS5, SRA, and NEAT1 lncRNAs are dysregulated in BC samples. However, except for MALAT1, the expression levels of all of these lncRNAs were significantly lower in cancers developed in younger cases, where poorer prognosis is suggested.	30126830
myocardial ischemia/reperfusion injury		Overexpression, knockdown,	cardiomyocytes from arrhythmic model rats, rat cardiomyocytes	up-regulated	expression	Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway.	30145795
cervical cancer		qRT-PCR, luciferase reporter gene assay, overexpression, knockdown,	radiotherapy resistant model on cervical carcinoma cell CaSki,	up-regulated	expression	In cervical carcinoma, MALAT1 can interact with miR-143 to modulate tumor cell survival, apoptosis and cell cycle, thus affecting radiotherapy efficiency.	30178834
laryngeal squamous cell carcinoma		qRT-PCR, knockdown, overexpression,	nasopharyngeal epithelial(NPE) cell line	differential expression	expression	MALAT-1 gene cansignificantly suppress the proliferation, invasion and migration and promotes apoptosis of the cancer cells.	30187883
colorectal cancer		qRT-PCR,	non-malignant and tumour tissue	down-regulated	expression	Changes in expression of lncRNAs between MT and TT hold potential to be used as prognostic biomarkers in CRC patients.	30205577
breast cancer		knockdown	tissue samples from 20 BC cases and 20 healthy, MCF-7 cells	up-regulated	expression	MALAT1 promoted angiogenesis in BC, which may be related to the expression of miR-145.	30226550
hilar cholangiocarcinoma		qRT-PCR,	plasma samples of HC patients	up-regulated	expression	PCAT1, MALAT1, and CPS1-IT1 may act as novel early diagnosis biomarkers for predicting HC.	30231247
neonatal respiratory distress syndrome		knockdown, immunocytochemistry	peripheral blood mononuclear cells, A549 cells	up-regulated	expression	Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome.	30243953
non-small cell lung cancer		knockdown, overexpression, qRT-PCR, western blot, luciferase reporter assay	tumor tissues, adjacent normal tissues	up-regulated	expression	MALAT1 decreased the sensitivity of NSCLC to cisplatin via the regulation of miR-145 and KLF4.	30250547
bladder cancer		qRT-PCR,	urine samples	up-regulated	expression	PCAT-1 and MALAT1 was associated with poor recurrence-free survival (RFS) of non-muscle-invasive BC	30268126
diabetes-related end-stage renal disease		qRT-PCR,	ESRD serum	up-regulated	expression	MALAT1 up-regulation and miR-499 down-regulation might be involved in diabetic nephropathy-related ESRD pathogenesis.	30270667
ovarian cancer		knockdown, qRT-PCR	ovarian cancer cells	up-regulated	expression	The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing.	30294913
endometriosis		knockdown	cultured human endometrial stromal cells	up-regulated	expression	LncRNA-MALAT1 mediates hypoxia-induced pro-survival autophagy of endometrial stromal cells in endometriosis.	30324652
endometriosis		qRT-PCR, knockdown, western blot	52 endometriosis patients and 52 controls cell line	down-regulated	expression	Down-regulation of long non-coding RNA MALAT1 inhibits granulosa cell proliferation in endometriosis by up-regulating P21 via activation of the ERK/MAPK pathway.	30371869
bladder cancer		knockdown	BC tissues and cell lines compared with the adjacent non-tumour tissues and the normal urinary tract epithelial cell line SV-HUC-1	up-regulated	expression	Knockdown of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 inhibits the proliferation and migration of bladder cancer cells by modulating the microRNA-34a/cyclin D1 axis.	30387807
breast cancer		knockdown	breast cancer patients, xenograft mice	up-regulated	expression	MALAT1 is closely related to recurrence and metastasis of breast cancer patients with early postoperative fever.	30416660
hepatocellular carcinoma		qRT-PCR,	HCC tissues	down-regulated	expression	Development of a GeXP-Based Multiplex RT-PCR Assay for Detection of Long Noncoding RNA in Hepatocellular Carcinoma.	30423146
dexamethasone-induced injury	dexamethason	qRT-PCR, western blot, Knockdown,	the established osteoblastic cell lines (OB-6 and hFOB1.19) and primary human osteoblasts.	down-regulated	expression	MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling	30439702
hepatocellular carcinoma		overexpression, knockdown, mimic, luciferase reporter assay,	HepG2-X cells	up-regulated	expression	Interaction of lncRNA-MALAT1 and miR-124 regulates HBx-induced cancer stem cell properties in HepG2 through PI3K/Akt signaling.	30500989
transitional cell carcinoma			TCC patients compared to controls	up-regulated	expression	The proposed panel of lncRNAs (composed of UCA1-201, UCA1-203, MALAT1, and LINC00355) had 92% sensitivity and 91.7% specificity for diagnosis of bladder cancer from normal samples.	30568497
atherosclerosis			Malat1-/- mice inflammatory CD45+ cells compared with Apoe-/- Malat1+/+ control mice	down-regulated	expression	Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.	30586743
prostate cancer		ChIP, luciferase reporter assays, Overexpression, knockdown	PCa cell lines.	up-regulated	expression	IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway.	30591689
neuroendocrine neoplasms		microarray, chromogenic in situ hybridization (ISH),	83 cases of GEP-NENs (60 grade 1, 17 grade 2, and 6 grade 3 tumors) diagnosed during the years 2005-2017.	up-regulated	expression	High expression of HOTAIR was associated with lower presenting T and M stages and subsequent development of metastases (P < 0.05). MALAT1 expression was associated with presenting T stage and development of metastases (P < 0.05).	30600442
tongue squamous cell carcinoma		qRT-PCR, western blot, knockdown, overexpression,	tumor tissues and adjacent healthy tissues of tongue cancer patients, and the serum from tongue cancer patients as well as healthy controls,	up-regulated	expression	LncRNA MALAT1 expression inhibition can inhibit the proliferation, migration and invasion of tongue cancer cells by inactivating the PI3K/Akt pathway and downregulating MMP-9.	30657561
beta-thalassemia		qRT-PCR	Fifty consecutive β-thal patients and 50 unrelated controls	up-regulated	expression	LncRNAs MALAT1, MIAT, and ANRIL might be implicated in β-thal pathogenesis and could provide new molecular biomarkers for β-thalassemia after validation in large-scale future studies.	30665334
neuropathic pain		overexpression, knockdown, loss of function,	chronic constriction injury (CCI) rat model, CCI rat microglial cells	up-regulated	expression	We indicated that suppression of MALAT1 ameliorated neuropathic pain progression via miR-206/ZEB2 axis.	30740678
coronary atherosclerotic heart disease		qRT-PCR, Knockdown, overexpression, western blot, Luciferase reporter assay,	CAD blood samples and endothelial progenitor cells (EPCs)	up-regulated	expression	MALAT1/miR-15b-5p/MAPK1 mediates endothelial progenitor cells autophagy and affects coronary atherosclerotic heart disease via mTOR signaling pathway.	30787203
multiple sclerosis			428 Iranian MS patients and 505 healthy subjects		expression	The A T haplotype (rs619586 and rs3200401, respectively) within MALAT1 was associated with MS risk.	30822187
recurrent miscarriage		luciferase assay, overexpression	villous from 27 RM patients and paired healthy controls	down-regulated	expression	P53 overexpression lead to decreased cells proliferation, migration, invasion and increased apoptosis. Meanwhile, MALAT1 overexpression partially restored these function of p53 overexpression.	30848022
colorectal cancer		qRT-PCR,western blot, luciferase assay	fresh colorectal cancer tissues, adjacent non-tumor tissues, FHC, LOVO, SW620, CL40 and HCT116 cells	up-regulated	expression	MALAT1 might regulate miR-363-3p and/or EZH2 expression.	30972996
diabetic retinopathy	high glucose (HG).	qRT-PCR, Luciferase, ELISA, western blot, Knockdown,	hRMECs treated with HG	up-regulated	expression	MALAT1 may serve as a potential target for anti-angiogenic therapy for DR.	30988072
colorectal cancer		mimic, Knockdown	HCT-116 cells, a xenograft model based on Balb/c mice	up-regulated	expression	Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.	31012108
Mycosis fungoides infection	CCL21	Knockdown,qRT-PCR,	MF cell line	up-regulated	expression	CCL21 Induces mTOR-dependent MALAT1 Expression, Leading to Cell Migration in Cutaneous T-Cell Lymphoma.	31028199
liver ischemia/reperfusion injury	hypoxia/reoxygenation		Hepatic ischemia-reperfusion (I/R) cell	up-regulated	expression	LncRNA MALAT1 cessation antagonizes hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and inflammation via the HMGB1-TLR4 axis.	31075559
breast cancer	hypoxia	overexpression	breast cancer cells	up-regulated	locus	cancer cell-specific chromatin-chromatin interactions are formed at the MALAT1 locus under hypoxia, implicating a novel mechanism of MALAT1 regulation in cancer.	31167784
gastric cancer		overexpression	gastric tumors, plasma	up-regulated	expression	lncRNA MALAT1 overexpression promotes proliferation, migration and invasion of gastric cancer by activating the PI3K/AKT pathway.	31186750
coronary artery disease		qRT-PCR	110 stable CAD patients and 117 controls		expression	The median MIAT expression level in CAD patients was significantly 12-fold higher than controls (p<0.001). Otherwise, the median MALAT1 expression level was comparable in patient and control groups.	31188931
sepsis	lipopolysaccharide (LPS)	RIP, qRT-PCR, overexpression, knockdown	human dermal microvascular endothelial cells (HMECs)		expression	RIP and qRT-PCR analysis revealed that the lncRNAs HULC, UCA1, and MALAT-1 were significantly enriched with the CMPs after sepsis.	31231228
acute myocardial infarction		qRT-PCR	peripheral blood mononuclear cells, blood sample	up-regulated	expression	lncRNA H19, MIAT and MALAT1 were significantly higher in AMI patients than in healthy control	31302423
colorectal cancer			CRC cells and human tissues	up-regulated	mutation	MALAT1 rs664589 polymorphism inhibits binding to miR-194-5p contributing to colorectal cancer risk, growth and metastasis.	31311811
diabetic retinopathy	aflibercept	qRT-PCR	plasma	down-regulated	expression	downregulated baseline plasma levels of RNCR2 and NEAT2 were observed in glycemic-controlled DR patients.	31327036
colorectal cancer		qRT-PCR	blood samples	up-regulated	expression	The expression levels of MALAT1 were significantly upregulated .	31328973
breast cancer		FISH, qRT-PCR,knockdown	breast cancer cells	up-regulated	expression	TALAM1 cooperates with MALAT1 in the regulation of the properties guiding breast cancer aggressiveness and malignancy.	31382922
diabetic nephropathy	high glucose (HG)	qRT-PCR, western blot, immunofluorescence assay, ELISA, knockdown	HK-2 cells	up-regulated	expression	lncRNA MALAT1 mediated high glucose-induced HK-2 cell epithelial-to-mesenchymal transition and injury.	31388927
periodontitis		overexpression, qRT-PCR, western blot	human periodontal ligament stem cell (PDLSC)	up-regulated	expression	MALAT1 overexpression promotes the proliferation of human periodontal ligament stem cells by upregulating fibroblast growth factor 2.	31410118
cutaneous squamous cell carcinoma	Dihydromyricetin (DHM)	overexpression	CSCC cell	down-regulated	expression	Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma.	31413743
glioblastoma		qRT-PCR, DNA-seq	GB tissues and normal brain tissues	up-regulated	expression	high MALAT1 expression was an unfavorable prognostic factor for overall survival (p = 0.034) in IDH1/2 wild-type primary GBs.	31479414
type 2 diabetes mellitus		knockdown, RIP, Dual-luciferase reporter	mouse model, human umbilical vein endothelial cells	down-regulated	expression	Exercise Reduces Insulin Resistance in Type 2 Diabetes Mellitus via Mediating the lncRNA MALAT1/MicroRNA-382-3p/Resistin Axis.	31479923
Obese osteoarthritis		RNA-seq,qRT-PCR,knockdown,ELISA	OA fibroblasts	up-regulated	expression	Synovial fibroblasts from obese OA patients exhibit an inflammatory phenotype. MALAT1 lncRNA may mediate joint inflammation in obese OA patients.	31682073
colon cancer		qRT-PCR, knockdown, western blot,	SW480 cells	up-regulated	expression	MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis.	31733641
thyroid cancer		luciferase assay	thyroid cancer (PTC) patients and controls	down-regulated	mutation	G allele of rs619586 could significantly decrease MALAT1expression, reduce PTC proliferation, and directly increase PTC apoptosis.	31788131
hypopharyngeal carcinoma		qRT-PCR, knockdown	Tumor tissues and adjacent non-cancer tissues of 24 patients	up-regulated	expression	our deactivation model of MALAT1 disentangled the active function of it as a regulator of gene expression governing the hallmarks of laryngeal and hypopharyngeal cancer	31792655
laryngeal carcinoma		qRT-PCR, knockdown	Tumor tissues and adjacent non-cancer tissues of 24 patients	up-regulated	expression	our deactivation model of MALAT1 disentangled the active function of it as a regulator of gene expression governing the hallmarks of laryngeal and hypopharyngeal cancer	31792655
prostate cancer	total saponins from Paris forrestii (PCT3)	western blot, qRT-PCR	PCa cells	up-regulated	expression	By using q-PCR, the expression levels of NEAT1, MALAT1, TIPIN, LYAR, IQGAP3, GINS2, and ZGRF1 were validated as consistent with microarray data, suggesting that these genes might participate in the PCT3 anticancer effect.	31810132
gastrointestinal stromal tumor	imatinib	qRT-PCR	FFPE tissue specimens from 40 surgically resected and metastatic GIST patients	up-regulated	expression	The percentage of both H19 and MALAT1 upregulation was significantly higher in patients with time to progression (TTP) < 6 months as compared to patients with TTP > 6 months.	31827510
laryngeal squamous cell carcinoma	cisplatin, 5-fluorouracil, paclitaxel, and vincristine		108 pairs of tumor tissues and matched para-tumor normal tissues, LSCC cell lines, including TU686, TU177, AMC-HN-8, and LSC-1	up-regulated	expression	LncRNA MALAT1 counted in triggering tolerance of LSCC against chemo-drugs by boosting metastasis and depressing apoptosis of tumor cells.	31837057
sepsis		qRT-PCR	patients with sepsis and healthy controls (HCs)	up-regulated	expression	High MALAT1 expression was an independent risk factor for sepsis (P<0.001), septic shock (P=0.030) and poor prognosis (P=0.015).	31922243
bladder cancer		qRT-PCR	urine samples from both bladder cancer patients and urocystitis patients.		expression	Using this panel, bladder cancer patients could be discriminated from urocystitis patients, with sensitivity and specificity reaching 95.7% and 94.3%, respectively.	31949480
gastric cancer		qRT-PCR	gastric cancer tissues and paired adjacent non-cancerous tissues (ANCTs)		expression	Relative transcription quantities of HULC, MALAT1, OIP5-AS1, PVT1, FAS-AS1 and THRIL were associated with the site of the primary tumor. relative expression levels of PVT1 were associated with history of smoking (P value = .04).	31982396
diabetic retinopathy	high-glucose (HG)	immunofluorescence, knockdown, western blot, ELISA	Retinal vascular endothelial cells	up-regulated	expression	promotes HG-induced angiogenesis and inflammation in RVECs by upregulating ER stress, and might be target for treating DR.	31986419
acute myocardial infarction		Knockdown, qRT-PCR, western blot, Luciferase activity,	adult male Sprague-Dawley (SD) rats, HL-1 cells	differential expression	expression	MALAT1 reduced the protective effect of miR-125b-5p on injured cells through upregulation of NLCR5. This study highlights the role of MALAT1 in the pathogenesis of AMI and may guide future genetic therapeutic strategies for AMI treatment.	32010261
ulcerative colitis	lipopolysaccharides (LPS)	qRT-PCR,	UC patients	up-regulated	expression	MALAT1 promotes ulcerative colitis by upregulating ANRIL.	32026279
diabetic neurodegeneration		immunofluorescence	mice	up-regulated	expression	Inhibiting retinal MALAT1 results in mitigative effects on the retinal photoreceptors, thus alleviating diabetic neurodegeneration.	32090029
rheumatoid arthritis-associated interstitial lung disease		microarray, qRT-PCR	PBMCs from middle-aged female healthy controls, and RA and RA-ILD patients	up-regulated	expression	NR_002819, NR_038935, and ENST00000603415 increased in RA-ILD patients.	32133566
cerebral ischemia/reperfusion injury		knockdown, western blot	mouse model		expression	Knockdown of MALAT1 increased cell viability and reduced cell apoptosis in MA-C cells	32138732
multiple myeloma		Knockdown, microarray, qRT-PCR, western blot	human myeloma cell lines (HMCLs) JJN3 and RPMI-8226	up-regulated	expression	On the other hand, loss of FAM46C up-regulates metastasis-associated lncRNA MALAT1 and results in a sharp increase in the migration ability.	32141701
atherosclerosis	ox-LDL	Knockdown, qRT-PCR	macrophages	up-regulated	expression	LncRNA MALAT1 Enhances Ox-LDL-induced Autophagy via the SIRT1/MAPK/NF-κB Pathway in Macrophages	32183682
prostate cancer	Quercetin	Overexpression, qRT-PCR, western blot, Immunohistochemistry stain	Human prostate cancer PC-3 cell lines, male BALB/c nude mice	down-regulated	expression	MALAT1 Overexpression in PC cells resulted in the resistance against quercetin treatment.	32210615
gastric cancer	cisplatin	Knockdown, Overexpression, qRT-PCR, western blot,	GC tissues and normal gastric tissues, Human GC cell lines (MKN45, MKN28, MGC-803, HGC-27, NCI-N87, AGS and GES-1), Cisplatin-resistance MGC803 cells (MGC803/CDDP)	up-regulated	expression	MALAT1 promotes malignant progression of GC and contributes to cisplatin resistance of GC cells, indicating MALAT1 may serve as a biological hallmark for predicting the prognosis of GC.	32214850
ischemic stroke		SNPs selection, Genotyping, Bioinformatics analysis	ischemic stroke patients and health control	differential expression	mutation	These results suggest that the rs1194338 AC/AA genotypes may be a protective factor for IS.	32238151
type 1 diabetes mellitus	IL-1β	Knockdown, Overexpression, qRT-PCR, western blot, ChIP-qRT-PCR	Islets were isolated from non-obese diabetic (NOD) mice and wild type (WT) mice, Mouse islets and β cell line (Min6)	up-regulated	epigenetics	MALAT1 induces the dysfunction of β cells via reducing the H3 histone acetylation of the PDX-1 promoter and subsequently inhibiting the expression of PDX-1, thus suppressing the insulin secretion.	32243891
systemic lupus erythematosus		knockdown	OAS2, OAS3, and OASL expression in CD19+ B or CD4+ T cells	up-regulated	expression	Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an aberrant activation of immune cells partly due to the dysfunction of cytokines	32321151
colorectal cancer	Thapsigargin	Knockdown, qRT-PCR, western blot,	colorectal cancer patients tissues, Human CRC cell lines (HCT116, SW620, SW1116 and HT29)	up-regulated	expression	These findings indicated that ER stress may promote the migration of CRC cells and contribute to the progression of CRC through the activation of the IRE1/XBP1 and PERK/eIF2α/A TF4 signaling pathways.	32323831
hepatocellular carcinoma	cisplatin	Knockdown, qRT-PCR, western blot, RIP, Luciferase Reporter Assays	female NOD/SCID mice, human HCC cell lines, Huh7, Mahlavu, SK-Hep1 and hepatoblastoma cells HepG2, as well as the non-tumor liver cell line THLE-2	up-regulated	expression	MALA T1/Wnt is a targetable molecular candidate, and the therapeutic targeting of MALA T1/Wnt may constitute a novel promising anticancer strategy for HCC treatment.	32326045
severe pneumonia		qRT-PCR	elderly patients with severe pneumonia	up-regulated	expression	MALAT1 is highly expressed in the serum of elderly patients with severe pneumonia. Furthermore, it may serve as a marker for the prediction of survival of these patients.	32329872
type 2 diabetes mellitus		qRT-PCR, western blot		down-regulated	expression	Altered levels of MALAT1 and H19 derived from serum or serum exosomes associated with type-2 diabetes.	32346662
colorectal cancer		qRT-PCR, Knockdown, Luciferase reporter gene assay	CRC patients, CRC cell line HT-29	up-regulated	mutation	The risk of CRC was relatively higher among MALAT1 rs664589 G allele carriers, and the CRC patients with a G allele had a lower PFS. The likely mechanism underlying these observations is that the rs664589 SNP affects the binding efficiency between the lncRNA MALAT1 and the miRNA has-miR-194-5p, although this awaits laboratory confirmation.	32349546
neck squamous cell carcinoma	Radiation and Cisplatin.	knockdown, overexpression,	HNSCC cell lines	up-regulated	expression	MALAT1 knockdown enhanced the sensitivity of HNSCC cells to radiation and cisplatin partly through the induction of G2/M cell cycle arrest resulting in DNA damage and apoptosis.	32366409
obesity		qRT-PCR,	both the VAT and SAT of obese women		expression	Adipose tissue gene expression of long non-coding RNAs; MALAT1, TUG1 in obesity: is it associated with metabolic profile and lipid homeostasis-related genes expression?	32368256
amoeboid Invasion		RNA-seq, Knockdown, qRT-PCR, RNA pull-down	A375m2 and A2058 cells	up-regulated	expression	Our work is the first to address the role of MALAT1 in MA T/AMT (mesenchymal to amoeboid transition/amoeboid to mesenchymal transition) and suggests that increased MALAT1 expression is a common feature of amoeboid cells.	32369931
tongue squamous cell carcinoma		qRT-PCR	tongue SCC, compared to normal tongue tissues.	up-regulated	expression	LncRNA-MALAT1 is a promising biomarker for prognostic evaluation of tongue squamous cell carcinoma.	32383096
colorectal cancer		qRT-PCR		up-regulated	expression	A significant association was observed between the levels of MALAT1 and p53 in neoplasm tissues (R=0.073; P<0.05).	32391102

Function (not disease relevant)
Drug/chemo/stress	Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID
	overexpression	N/A	N/A	interaction	MALAT1 regulates AS by modulating the levels of active SR	20797886
	qRT-PCR	human TK6 (p53 positive) and WTK1 (p53 negative) cells	up-regulated	interaction	The lncRNA MALAT1 and SOX2OT were induced in both TK6 and WTK1 cells	23698766
arsenite	overexpression	human hepatic L-02 cells	up-regulated	interaction	In L-02 cells exposed to arsenite, the lncRNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and hypoxia inducible factors (HIFs)-α, the transcriptional regulators of cellular response to hypoxia, are over-expressed. In addition, HIF-1α, not HIF-2α, is involved in arsenite-induced glycolysis, and MALAT1 enhances arsenite-induced glycolysis.	27287256
	RNA immunoprecipitation,			interaction	Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.	27872311
				interaction		28635228
				interaction		28977880
	knockdown and transfection,qRT-PCR, Immunoblotting	human umbilical veendothelial cells		interaction	Knockdown of MALAT1 expression inhibits HUVEC proliferation by upregulation of miR-320a and downregulation of FOXM1 expression.	28977880
	luciferase assays, knockdown, overexpression,	human bone marrow-derived mesenchymal stem cells (hBMSCs)	down-regulated	interaction	MALAT1 acts to regulate Osx expression through targeting miR-143; thus, it is considered as a positive regulator in hBMSC osteogenic differentiation.	29741283
glucose	qRT-PCR, western blot, ELISA, RIP,RNA pull-down, Dual luciferase reporter assay	kidney tissues of diabetic mice and HK-2 cells treated with high glucose	up-regulated	interaction	LncRNA MALAT1 interacts with transcription factor Foxo1 to represses SIRT1 transcription in high glucose incubated HK-2 cells, which promotes high glucose-induced HK-2 cells injury.	29928873
Hyperbaric oxygen (HBO)	overexpression, knockdown, luciferase reporter	HCAECs under HBO treatment, A rat model of hind-limb ischemia	up-regulated	interaction	Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.	30301563
	qRT-PCR, knockdown, overexpression, immunohistochemical and bifluorescein reporter experiments	ADSCs induced osteogenic differentiation media for 21 days	up-regulated	interaction	LncRNA MALAT1 sponges miR-30 to promote osteoblast differentiation of adipose-derived mesenchymal stem cells by promotion of Runx2 expression.	30511267
lipopolysaccharide(LPS);HGF	RIP, knockdown, overexpression,	HSC-T6 cells, BRL-3 A cells and differentiated BM-MSCs	up-regulated	interaction	Β-catenin-coordinated lncRNA MALAT1 up-regulation of ZEB-1 could enhance the telomerase activity in HGF-mediated differentiation of bone marrow mesenchymal stem cells into hepatocytes.	30658864
PM2.5		lung bronchial epithelial cell	up-regulated	interaction	LncRNA MALAT1, an lncRNA acting via the miR-204/ZEB1 pathway, mediates the EMT induced by organic extract of PM2.5 in lung bronchial epithelial cells.	31042084
	qRT-PCR, overexpression, Luciferase reporter assays,	ox-LDL-treated VSMCs	down-regulated	interaction	LncRNA MALAT1 regulates proliferation and apoptosis of vascular smooth muscle cells by targeting miRNA-124-3p/PPARα axis.	31696492
	N/A	N/A	N/A	expression	Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms	23791884
		exosomes secreted from cultured cells		expression	lincRNA-p21 and ncRNA-CCND1 were the main molecules; exosome levels of them best reflect the change of their cellular levels upon exposure of the cells to bleomycin-induced DNA damage.	24798520
	Northern blot	pSV40-mMALAT1 vector, human genomic DNA			Interruption of the triple helix by the C-G doublet induces a “helical reset” that explains why triple-helical stacks longer than six do not occur in nature	24952594
	knockdown,	human fetal osteoblastic cell line hFOB 1.19	up-regulated	expression	RANKL, binding to its receptor RANK, inhibited cell proliferation via MALAT1 upregulation in osteoblast cells in vitro.	25817340
	nuclear magnetic resonance and Förster resonance energy transfer	N/A	N/A	mutation	An m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). This m(6)A-dependent regulation of protein binding through a change in RNA structure, termed "m(6)A-switch", affects transcriptome-wide mRNA abundance and alternative splicing. The m(6)A-modified hairpin has a predisposed conformation that resembles the hairpin conformation in the RNA-HNRNPC complex more closely than the unmodified hairpin.	26343757
	knockdown	Neuro-2a (N2a) cell	up-regulated	expression	Malat1 knockdown resulted in defects in neurite outgrowth as well as enhanced cell death.	27374227
	qRT-PCR, western blot, cell immunofluorescence staining	endothelial progenitor cells (EPCs)		expression	MALAT1 Modulates TGF-β1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145.	28535533
		The human MHCC-LM3 cell line		expression	Importantly, the successful development of optical probes provides a basis for specific molecular diagnoses in the field of lncRNAs.	29156758
	knockdown	smooth muscle cells	differential expression	expression	MALAT1 promotes the transformation of smooth muscle cells from contraction to synthetic phenotypes.	29435112
		a rat model of ischemic wound healing and wound closure,	up-regulated	expression	Human Adipose-Derived Stem Cell Conditioned Media and Exosomes Containing MALAT1 Promote Human Dermal Fibroblast Migration and Ischemic Wound Healing.	30263873
	overexpression	HUVECs treated with ox-LDL	up-regulated	expression	LncRNA MALAT1 promotes oxidized low-density lipoprotein-induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway.	30485490
	knockdown, overexpression,	endothelial cells, an endothelial cell pyroptosis model by stimulating EA.hy926 human endothelial cells (EA.hy926 cells) with high glucose.	up-regulated	expression	Long noncoding RNA MALAT1 promotes high glucose-induced human endothelial cells pyroptosis by affecting NLRP3 expression through competitively binding miR-22.	30591217
high glucose	western blot,knockdown,immunofluorescence	Human umbilical vein endothelial cells	up-regulated	expression	Inhibiting lncRNA MALAT1 can promote endothelial cell proliferation, migration and angiogenesis and repress endothelial cell apoptosis simultaneously, whose mechanism may be related to the activation of the PI3K/Akt signaling pathway.	31646587

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
ABI3BP	RNA-DNA	regulation	N/A	MALAT1 was observed to down-regulate ABI3BP expression through recruitment of the enhancer of zeste homolog 2 (EZH2) to the ABI3BP promoter region while the silencing of MALAT1 or suppression of H3K27 methylation was observed to promote the expression of ABI3BP.	31174563
BRG1	RNA-Protein	binding	N/A	MALAT1 promotes HCC progression by binding BRG1 to epigenetically enhance inflammatory response in HCC tissues	30546959
c-MYC	RNA-DNA	binding	N/A	Moreover, c-MYC, a SYK-promoted gene, bound to the promoter of MALAT1 and transcriptionally activated MALAT1, which further promoted the proliferation of EWS cells.	28336564
CREB	RNA-Protein	binding	N/A	MALAT1 positively regulated YAP nuclear translocation by binding to CREB.	32069074
CTNNB1	RNA-DNA	binding	N/A	MALAT1 could bind to CTNNB1 promoter region and recruit methyltransferase to promote CTNNB1 promoter methylation, thereby inhibiting CTNNB1	30909750
DCP1A	RNA-RNA	regulation	N/A	We found that DCP1A is a direct target molecule of MALAT1.	29964337
DGCR8	RNA-Protein	regulation	N/A	Δsv-MALAT1 expression was associated with alterations of the pre-mRNAs alternative splicing machinery, and of the Drosha-DGCR8 complex required for non-coding RNA biogenesis. Alternative Δsv-MALAT1 transcript expression was associated to YAP protein status and with an activation of the PI3K-AKT pathway.	27172249
Drosha	RNA-Protein	regulation	N/A	Δsv-MALAT1 expression was associated with alterations of the pre-mRNAs alternative splicing machinery, and of the Drosha-DGCR8 complex required for non-coding RNA biogenesis. Alternative Δsv-MALAT1 transcript expression was associated to YAP protein status and with an activation of the PI3K-AKT pathway.	27172249
ERα	RNA-Protein	regulation	western blot	These transcripts appeared regulated by estrogens and able to control ERs function by interacting with ERα/ERβ as indicated by RNA-ChIP.	27922078
ERβ	RNA-Protein	regulation	western blot	These transcripts appeared regulated by estrogens and able to control ERs function by interacting with ERα/ERβ as indicated by RNA-ChIP.	27922078
ET-1	RNA-RNA	regulation	N/A	knocking down the pathogenetic lncRNAs ANRIL, MALAT1, and ZFAS1 subsequently prevented the glucose-induced upregulation of ET-1 transcripts.	29947532
EZH2	RNA-Protein	binding	ChIP	EZH2 binds to MALAT1.The 3' end of MALAT1 interacts with the N-terminal of EZH2.	26516927
EZH2	RNA-Protein	binding	N/A	Long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion.	26871474
EZH2	RNA-Protein	binding	N/A	Moreover, decreased phosphorylation of EZH2 at T350 attenuated the binding to MALAT1.	27998273
EZH2	RNA-Protein	binding	N/A	EZH2 is highly expressed and associated with the 3' end region of lncRNA MALAT1 in colorectal cancer,	28069878
EZH2	RNA-Protein	binding	western blot	MALAT1 directly binds to EZH2 and SUZ12, and BMI1 activation may be induced possibly through H3K27me3.	28412742
EZH2	RNA-Protein	binding	N/A	Expression of Ezh2, Notch1, Hes1, MMP-9, and Vimentin was significantly decreased and expression of E-cadherin was significantly increased when cells were transfected with sh-MALAT1 compared with the nontransfected cells (P<0.05).	29916899
EZH2	RNA-Protein	binding	N/A	MALAT1 was observed to down-regulate ABI3BP expression through recruitment of the enhancer of zeste homolog 2 (EZH2) to the ABI3BP promoter region while the silencing of MALAT1 or suppression of H3K27 methylation was observed to promote the expression of ABI3BP.	31174563
EZH2	RNA-Protein	binding	N/A	lncRNA MALAT1 interacting with EZH2 stimulated AKT-1 phosphorylation and decreased BRCA1 expression	31830649
EZH2	RNA-Protein	binding	western blot, ChIP, RIP	MALAT1 facilitated the enrichment of enhancer of zeste homolog 2 (EZH2) at the promoter region of mir-22 and E-cadherin, which was repressed by MALAT1 knockdown	32129914
FGF2	RNA-Protein	regulation	western blot	MALAT1-mediated FGF2 protein secretion from TAMs inhibits inflammatory cytokines release, promotes proliferation, migration, and invasion of FTC133 cells and induces vasculature formation.	28543663
FOXO2	RNA-Protein	binding	western blot, ELISA	interaction between MALAT1 and Foxo1 was observed in HK-2 cells and the interaction was promoted by high glucose treatment. Foxo1 activated SIRT1 transcription by binding to its promoter, and MALAT1 repressed SIRT1 expression through targeting Foxo1.	29928873
G9a	RNA-Protein	binding	N/A	MALAT recruits methyltransferase G9a to elevate H3K9me1 and epigenetically inhibits klotho expression,	30762931
GAGE6	RNA-DNA	binding	N/A	Upregulated MALAT-1 released the binding of PTB-associated splicing factor (PSF) to its target gene, GAGE6, and thus promoted proliferation, migration and invasion of A549 cells following hypoxia exposure.	29928414
GLI1	RNA-Protein	regulation	FISH	Overexpression of GLI1 through a recurrent MALAT1-GLI1 translocation or GLI1 up-regulation delineates a pathogenically distinct subgroup of plexiform fibromyxomas with activation of the Sonic Hedgehog signalling pathway.	27101025
HIF-1α	RNA-Protein	regulation	N/A	MALAT1, acting through HIF-1α stabilization, is a mediator that enhances glycolysis induced by arsenite.	27287256
hnRNPH1	RNA-Protein	binding	N/A	Minigene-based splicing assays upon MALAT1 modulation recapitulated IL7R and SP140 isoform unbalances observed in patients.	30566690
HuR	RNA-Protein	binding	N/A	MALAT1 interacted with RNA binding protein HuR, and silencing of MALAT1 greatly enhanced the posttranscriptional regulation of TIA-1 and had further effects on inhibiting autophagy. MALAT1 was speculated to regulate tumorigenesis via HuR-TIA-1-mediated autophagic activation. Hence,	27371730
ID4	RNA-Protein	regulation	N/A	Our results highlight a key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins.	28652379
IDO	RNA-DNA	regulation	N/A	We found that MALAT1-induced VEGF mediated these effects of MALAT1 on MSCs. Furthermore, we found that MALAT1-overexpressed MSCs promoted M2 macrophage polarization and this effect was mediated by MALAT1-induced IDO expression,	28176360
IL-6	RNA-DNA	regulation	N/A	MALAT1 is upregulated in lipopolysaccharide (LPS)-activated macrophages. Knockdown of MALAT1 increases LPS-induced expression of TNFα and IL-6. Mechanistically, MALAT1 was found to interact with NF-κB in the nucleus, thus inhibiting its DNA binding activity and consequently decreasing the production of inflammatory cytokines.	27434861
IL-6	RNA-DNA	regulation	N/A	MALAT1 is capable of impacting the expressions of inflammatory transcripts through its association with components of the PRC2 complex in diabetes. Furthermore, the vitreous humors from diabetic patients revealed increased expressions of MALAT1, TNF-α, and IL-6.	29695738
IQGAP1	RNA-RNA	regulation	western blot	MALAT1 promoted the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1.	27470543
JMJD2C	DNA-Protein	regulation	N/A	Further molecular mechanism investigation demonstrated that JMJD2C protein translocated into the nuclear, lowered the histone methylation level of MALAT1 promoter in the sites of H3K9me3 and H3K36me3, up-regulated the expression of MALAT1, and enhanced the β-catenin signaling pathway in CRC cells.	31665047
KLF5	RNA-DNA	regulation	N/A	Luciferase reporter assays and RNA immunoprecipitation experiments demonstrated molecular binding between MALAT1 and hsa‑miR‑124‑3p.1.KLF5 was confirmed to be a target gene of MALAT1/hsa‑miR‑124‑3p.1.	31257528
klotho	RNA-DNA	binding	N/A	MALAT recruits methyltransferase G9a to elevate H3K9me1 and epigenetically inhibits klotho expression,	30762931
KTN1	RNA-DNA	regulation	N/A	Mechanistic study revealed that MALAT1 interacts with c-MYC to form a complex and directly binds to the promoter region of KTN1 gene and enhances its transactivation to positively regulate EGFR protein expression.	30683916
LIG3	RNA-Protein	binding	N/A	MM express elevated MALAT1 and involve in alternative non-homozygous end joining (A-NHEJ) pathway by binding to PARP1 and LIG3, two key components of the A-NHEJ protein complex.	29632340
Lin28A	RNA-Protein	regulation	N/A	Lin28A was found to harbor binding sites on MALAT1 sequences and associated with MALAT1, and increased MALAT1 stability and expression.	29204769
Livin	RNA-DNA	regulation	RIP	These data indicate that lncRNA MALAT-1-mediated promotion of RCC proliferation and metastasis may be due to the upregulation of the expression of Livin.	27655020
LTBP3	RNA-DNA	binding	ELISA	lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoterto increase expression of LTBP3 gene.	25187517
LTBP3	RNA-DNA	regulation	N/A	MALAT1 could promote tumor growth and metastasis by activating LTBP3, which could also be up-regulated by HBx.	28469957
LTR	RNA-DNA	regulation	N/A	Mechanistically, through an association with chromatin modulator polycomb repressive complex 2 (PRC2), MALAT1 detached the core component enhancer of zeste homolog 2 (EZH2) from binding with HIV-1 LTR promoter, and thus removed PRC2 complex-mediated methylation of histone H3 on lysine 27 (H3K27me3) and relieved epigenetic silencing of HIV-1 transcription.	30788509
MDR1	RNA-RNA	regulation	western blot	MALAT1 decreased DDP sensitivity in vitro and in vivo by upregulating MRP1 and MDR1 via STAT3 activation.	29505924
METTL16	RNA-Protein	binding	N/A	Methyltransferase-like prote16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.	27872311
miR-1	RNA-RNA	binding	western blot	mir-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1.	26275461
miR-1	RNA-RNA	regulation	western blot, RIP	There was reciprocal repression between MALAT1 and mir-1, and slug was identified as a downstream target of mir-1.	26482776
miR-1	RNA-RNA	binding	N/A	Mechanistically, in silico analysis and experimental validation both confirmed that microRNA-1 (mir-1) was the mediator connecting MALAT1-Cx43 axis:	31280017
miR-101	RNA-RNA	regulation	N/A	A significant negative correlation exists between mir-101 or mir-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues.	25538231
miR-101	RNA-RNA	regulation	N/A	S-PGEA-FA-mediated mir-101 and mir-217 delivery effectively inhibited ESCC development, indicating the s-PGEA-FA nanovector was promising for future ESCC therapy.	28150831
miR-101	RNA-RNA	binding	N/A	Malat1 was found to act as an endogenous sponge by directly binding to mir-101 to reduce mir-101.	31372165
miR-101	RNA-RNA	binding	N/A	MALAT1 induces protective autophagy and suppresses apoptosis in GBM cells via sponging miRNA-101 and increases temozolomide chemoresistance via enhancing epithelial-mesenchymal transition, suppressing mir-203 and promoting thymidilate synthase.	32119915
miR-101	RNA-RNA	binding	western blot	MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101.	28551849
miR-101-3p	RNA-RNA	binding	western blot	Dual luciferase reporter and RNA immunoprecipitation assays showed direct binding of miR-101-3p to MALAT1.	29484127
miR-101-3p	RNA-RNA	regulation	N/A	MALAT1 affected the cisplatin resistance of the BC cells via regulating the mir-101-3p/VEGF-C pathway.	31650173
miR-101-3p	RNA-RNA	binding	N/A	MALAT1 could regulate the radio-resistance in colorectal cancer via sponging mir-101-3p.	32380053
miR-106b-5p	RNA-RNA	regulation	N/A	The long non-coding RNA MALAT1 regulated the miR-106b-5p expression and further mediated the mobility of SLAIN2-related MTs by functioning as a competing endogenous RNA in vitro and in vivo, which resulted in the progression of CRC.	30797712
miR-122	RNA-RNA	regulation	N/A	The miR-122-IGF-1R signaling correlated with the dysregulated MALAT1 expression in gastric cancer.	27486823
miR124	RNA-RNA	binding	N/A	However, recent evidence has demonstrated that lncRNAs can serve as sponges to titrate microRNAs (miRNAs) and prevent them from binding to mRNAs by acting as competing endogenous RNAs (ceRNAs).44 In the development of non‐small cell lung cancer (NSCLC), previous studies have uncovered that MALAT1 can act as a ceRNA to modulate miR124/STAT3.43	30784209
miR-124	RNA-RNA	binding	N/A	MALAT1 acted as an endogenous potent regulator by directly binding to miR-124 and down-regulating miR-124 expression.	26918449
miR-124	RNA-RNA	binding	N/A	Overexpression promoted tongue cancer cell growth by targeting miR-124. MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation.	28260102
miR-124	RNA-RNA	binding	N/A	These results revealed that miR-124 can act as a direct target of MALAT1 in NSCLC.	29215698
miR-124	RNA-RNA	regulation	western blot	The oe-MALAT-1+miR-124 mimics group had increased E-cadherin and cell apoptosis, but decreased vimentin, cell variability, cell invasion, and migration ability in comparison with the oe-MALAT-1 group.	29782349
miR-124-3p	RNA-RNA	binding	western blot, RIP	MALAT1 and miR-124-3p bind directly and reversibly to each other.	31466138
miR-124-3p	RNA-RNA	binding	N/A	Dual-luciferase reporter gene assay verified that MALAT1 could sponge miRNA-124-3p, and moreover, PPARα was the direct target of miRNA-124-3p.	31696492
miR-124-3p	RNA-RNA	binding	western blot, dual-luciferase reporter assay	The plasma levels of hsa-miR-124-3p and hsa-miR-135a-5p of hypertensive patients were negatively correlated with lncRNA MALAT1 (r=-0.64, -0.72; P<0.01, P<0.01, respectively).	32222724
miR-124-3p.1	RNA-RNA	binding	N/A	Luciferase reporter assays and RNA immunoprecipitation experiments demonstrated molecular binding between MALAT1 and hsa‑miR‑124‑3p.1.KLF5 was confirmed to be a target gene of MALAT1/hsa‑miR‑124‑3p.1.	31257528
miR-125	RNA-RNA	binding	N/A	MALAT1 acted as a sponge for miR-125. JMJD6 was a target of miR-125 whose expression was negatively regulated by miR-125.	29605300
miR-125a	RNA-RNA	binding	N/A	MALAT1 acted as a sponge of miR-125a to modulate the IL-21R signaling pathway in GC cells and represented a risk factor for survival and recurrence in patients with GC.	30387833
miR-125a-3p	RNA-RNA	binding	N/A	MALAT1 modulates FOXM1 expression via being a miR-125a-3p sponge, thus promoting HCC progression	31777593
miR-125b	RNA-RNA	binding	N/A	Overexpression of MALAT1 was able to suppress the tumor inhibitory effect of miR-125b mimics via upregulating STAT3.	28926115
miR-125b	RNA-RNA	regulation	ELISA	lncRNA MALAT1 expression was negatively correlated with miR-125b level in both sepsis patients (P < 0.001) and HCs (P < 0.001).	31301104
miR-125b	RNA-RNA	regulation	western blot	lnc- MALAT1 reversely regulated miR-125b expression, while miR-125b did not influence the lnc-MALAT1 expression.	31345147
miR-125b	RNA-RNA	binding	N/A	MALAT1 was confirmed to function as a competing endogenous RNA (ceRNA), interacting with miR-125b and miR-203a.	31557499
miR-1271-5p	RNA-RNA	binding	western blot	MALAT1 directly targeted miR-1271-5p and miR-1271-5p depression reverted the effects of MALAT1 knockdown on MM cells.	31953613
miR-127-5p	RNA-RNA	regulation	N/A	Targeting MALAT1 so as to rescue miR-127-5p expression in OA might help to inhibit chondrocyte proliferation through miR-127-5p-mediated OPN regulation and downstream PI3K/Akt pathway.	28590075
miR-129	RNA-RNA	regulation	dual-luciferase reporter assay, western blot	MALAT1 knockdown inhibited glioma stem cell proliferation via miR-129 enhancement. Meanwhile, miR-129 directly targeted at SOX2 and suppressed cell viability and proliferation of glioma stem cells by suppressing SOX2 expression. The down-regulation of MALAT1 and miR-129 overexpression both suppressed glioma tumour growth via SOX2 expression promotion in vivo.	29808528
miR-129-5p	RNA-RNA	binding	N/A	2 candidate miRNAs, miR-142-3p and miR-129-5p which may be associated with both MALAT1 and HMGB1. Luciferase reporter assay revealed a direct interaction between the 2 miRNAs and MALAT1, respectively, via a putative binding site within MALAT1.	28346809
miR-129-5p	RNA-RNA	binding	western blot	Knockdown of MALAT1 downregulated SOX9 expression by binding to miR‑129‑5p, thereby inhibiting the abnormal proliferation of IESCs via the WNT/β‑catenin signaling pathway.	32124944
miR-129-5p	RNA-RNA	binding	N/A	MALAT1 negatively regulated miR-129-5p through directly binding.	32135165
miR-129-5p	RNA-RNA	binding	ELISA	MiR-129-5p was shown to be a target of MALAT1.	32397779
miR-1297	RNA-RNA	binding	western-blot	MALAT1 was negatively correlation with miR-1297 and functioned as a molecular sponging miR-1297, antagonizing its ability to suppress HMGB2 expression.	28396617
miR-135a-5p	RNA-RNA	binding	western blot, dual-luciferase reporter assay	The plasma levels of hsa-miR-124-3p and hsa-miR-135a-5p of hypertensive patients were negatively correlated with lncRNA MALAT1 (r=-0.64, -0.72; P<0.01, P<0.01, respectively).	32222724
miR-1-3p	RNA-RNA	binding	N/A	miR‑1‑3p bound to MALAT1 and coronin 1C (CORO1C) 3' untranslated region, and MALAT1 competed with CORO1C for the binding sites of miR‑1‑3p.	31485645
miR-140	RNA-RNA	regulation	western blot, RIP, ChIP	There was reciprocal repression between MALAT1 and miR-140, and miR-140 mediated the effects that MALAT1 knockdown exerted.	26619802
miR-140	RNA-RNA	binding	western blot	Mechanistically, the interaction between MALAT1 and miR-140 or between miR-140 and VEGF-A was confirmed by multiple assays.	31693399
miR-140	RNA-RNA	binding	western blot	MiR-140 could directly bind with MALAT1 or BIRC6 3'UTR.	31935634
miR-140-5p	RNA-RNA	regulation	western blot, RIP	MALAT1 knockdown inhibited proliferation, migration, and invasion by upregulating miR-140-5p expression in TSCC cells.	30863103
miR-140-5p	RNA-RNA	binding	western blot, RIP	MALAT1 regulated Aurora-A expression by sponging miR-140-5p, thus promoting sorafenib resistance in HCC cells.	32220970
miR-142-3p	RNA-RNA	binding	N/A	2 candidate miRNAs, miR-142-3p and miR-129-5p which may be associated with both MALAT1 and HMGB1. Luciferase reporter assay revealed a direct interaction between the 2 miRNAs and MALAT1, respectively, via a putative binding site within MALAT1.	28346809
miR-142-3p	RNA-RNA	binding	western blot	Overexpressed MALAT1 acts as a competing endogenous RNA sponge for miR-142-3p in hepatocellular carcinoma.	31168355
miR-143	RNA-RNA	binding	N/A	MALAT1 could directly bind to miR-143 and negatively regulate its expression. Similarly, miR-143 could directly bind to the target site on the Osx 3'-UTR and then inhibit Osx expression.	29741283
miR-143-3p	RNA-RNA	binding	western blot	MiR-143-3p binds with MALAT1, and was regulated by MALAT1.	28543721
miR-144-3p	RNA-RNA	binding	N/A	Furthermore, we confirmed that MALAT1 and ROCK1/ROCK2 which were targeted by microRNA-144-3p (miR-144-3p) shared the same miR-144-3p combining site.	28938647
miR-145	RNA-RNA	regulation	RIP	miR-145 and MALAT1 were in the same Ago2 complex and there was a reciprocal repression between them.	26311052
miR-145	RNA-RNA	regulation	N/A	LncRNA-MALAT1 is sensitive to H/R injury and abrogates cardioprotective effects of Fentanyl by negatively regulating miR-145/Bnip3 pathway.	27862640
miR-145	RNA-Protein	binding	dual-luciferase reporter assay	We also identified miR-145 as a target of MALAT1 and SOX9. MALAT1 played a role in regulating cancer process by functioning as a competing endogenous RNA.	30285605
miR-145	RNA-RNA	binding	N/A	Mechanically, miR-145 could directly bind to MALAT1 and ADAMTS5.	31637891
miR-145	RNA-RNA	regulation	N/A	MALAT1/miR-145/focal adhesion kinase (FAK) pathway was confirmed to play an importment role in TGF-β1-induced renal fibrosis.	32203053
miR-145-5p	RNA-RNA	binding	N/A	MiR-145-5p as a target of MALAT1. MiR-145-5p overexpression in PC3-DTX led to inhibited cell proliferation, migration and invasion as well as reduced chemoresistance to DTX, which was attenuated by MALAT1.	29633510
miR-145-5p	RNA-RNA	regulation	western blot	LncRNA MALAT1 induced the upregulation of CRP expression through inhibiting the expression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p.	31342266
miR-146a	RNA-RNA	binding	ELISA	A potential binding region between MALAT1 and miR-146a was confirmed via RNA immunoprecipitation. The results revealed that the upregulation of MALAT1 reduced the expression of miR-146a, and there was a negative linear correlation between MALAT1 and miR-146a in a RNA-induced silencing complex-dependent manner.	29115409
miR-146a	RNA-RNA	binding	dual-luciferase reporter assay	MALAT1 targets miR-146a. MALAT1 silencing also resulted in the upregulation of miR-146a.	31472145
miR-146b-5p	RNA-RNA	binding	N/A	MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC.	28404923
miR-146b-5p	RNA-RNA	binding	N/A	A binding site in miR-146b-5p was existent in the 3' untranslated region of DNMT3A.	32343601
miR-149	RNA-RNA	binding	N/A	miR-149 directly targeted both lncRNA MALAT1 and the MyD88 gene.	31498515
miR-15	RNA-RNA	binding	N/A	MALAT1 modulates the cell proliferation, apoptosis, migration and invasion via directly interact with miR-383, miR-15, miR-205 and miR-375. By modulating the VEGFA expression, MALAT1 controls the capillary formation of HUVEC cells.	30173780
miR-150	RNA-RNA	binding	N/A	miR-150 was a target of Malat1 in ASMCs, and inhibited PDGF-BB-induced ASMC proliferation and migration, whereas the inhibition effect was effectively reversed by Malat1 overexpression.	31695627
miR-155	RNA-RNA	regulation	N/A	MALAT1 suppresses cell viability by down-regulating miR-155.	27904771
miR-155	RNA-RNA	binding	ELISA, western blot	MALAT1 could suppress the inflammatory cytokine release and cell apoptosis via sponging miR-155 to increase SOCS1 level, which in turn restrained JAK-STAT pathway.	30314869
miR-155	RNA-RNA	binding	N/A	MALAT1 constrained expression of miR-155 within CD4+ T cells by sponging it	31909418
miR-17	RNA-RNA	regulation	N/A	For β-cells (MIN6), cigarette smoke extract (CSE) increased the levels of thioredoxin-interacting protein (TXNIP) and the long noncoding (lnc)RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and downregulated the levels of the transcription factor, mafA, and microRNA (miR)-17.	29856480
miR-17-5p	RNA-RNA	binding	N/A	miR‑17‑5p was a direct target of MALAT1. miR‑17‑5p expression was downregulated and FOXA1 expression was upregulated in LPS‑treated A549 cells.	31257497
miR-17-5p	RNA-RNA	binding	western blot, luciferase reporter assay	MALAT1 could target miR‑17‑5p to regulate the expression level of ABCA1.	32319624
miR-181a-5p	RNA-RNA	binding	western blot, ELISA, luciferase reporter assay	MiR-181a-5p was demonstrated to be a target of LncRNA MALAT1	31397203
miR-181a-5p	RNA-RNA	binding	western blot	MALAT1 directly targeted and decreased the expression of miR-181a-5p, which in turn upregulated the expression of AKT3.	31480991
miR-182-5p	RNA-RNA	regulation	N/A	Transient knockdown of MALAT-1 mimicked the effects of miR-182-5p overexpression.	30037856
miR-183	RNA-RNA	binding	N/A	MALAT1 may function as a sponge competitive endogenous RNA (ceRNA) for miR-183, and thus regulate the molecular expression of ITGB1	27966454
miR-191-3p	RNA-RNA	binding	RIP	Notably, HuR is negatively regulated by miR-191-3p, and MALAT1, through sponging miR-191-3p, positively regulates HuR levels.	31301902
miR-194-5p	RNA-RNA	binding	N/A	MALAT1 could directly target miR-194-5p to suppress its expression, and ACVR2B was the targeted molecule of miR-194-5p (P < 0.05).	30334578
miR-195	RNA-RNA	binding	western blot	MALAT1 could sponge miR-195 to regulate the expression of PD-L1.	30898647
miR-197-3p	RNA-RNA	binding	N/A	MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR-197-3p and regulating p120-ctn expression	30841025
miR-199a	RNA-RNA	binding	N/A	MALAT1 promoted ZHX1 expression via acting as a competing endogenous RNA by sponging miR-199a.	31648104
miR-200a	RNA-RNA	binding	ChIP	MARCH7 interacted with MALAT1 by miR-200a (microRNA-200a). MARCH7 may function as a competing endogenous RNA (ceRNA) to regulate the expression of ATG7 by competing with miR-200a. MARCH7 regulated TGF-β-smad2/3 pathway by interacting with TGFβR2.	29794480
miR-200a	RNA-RNA	binding	dual-luciferase reporter assay	LncRNA MALAT1 functions as a competing endogenous RNA to regulate the expressions of ZEB1 and ZEB2 by sponging miR-200a.	28635228
miR-200a	RNA-RNA	binding	western blot, luciferase reporter assay	MALAT1 promoted the proliferation and gefitinib resistance of lung cancer cells by sponging miR-200a.	31133357
miR-200a	RNA-RNA	binding	luciferase reporter assay	MALAT1 Regulates Hepatocellular Carcinoma Growth Under Hypoxia via Sponging MicroRNA-200a.	31347327
miR-200a-3p	RNA-RNA	binding	N/A	MiR-200a-3p could bind to either MALATA1 or PDCD4. Combining with the cytoplasmic location of MALAT1	30841417
miR-200a-3p	RNA-RNA	binding	N/A	MALAT1 promoted proliferation, mobility, migration, and invasion of NSCLC cells via sponging miR-200a-3p.	31240979
miR-200b	RNA-RNA	binding	N/A	TFAP2C-activated MALAT1 modulated the chemoresistance of LUAD cells by sponging miR-200b to upregulate E2F3 and ZEB1.	30771618
miR-200c	RNA-RNA	binding	N/A	We found that miR-200c bound directly to MALAT1 using luciferase reporter and qRT-PCR assays. MALAT1 and miR-200c are reciprocally repressed, and TGF-β increased MALAT1 expression by inhibiting miR-200c.	27693631
miR-200c-3p	RNA-RNA	binding	western blot	MALAT1 downregulated the expression of miR-200c-3p by directly binding to miR-200c-3p. Furthermore, miR-200c-3p inhibited the autophagy and survival in BMECs by binding to 3'UTR of SIRT1, whereas MALAT1 overturned the inhibitory effect of miR-200c-3p.	30496821
miR-200s	RNA-RNA	binding	N/A	MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo.	26461224
miR-202	RNA-RNA	binding	N/A	MALAT1 could act as a competing endogenous RNA (ceRNA) by sponging miR-202 in NSCLC	31863664
miR-202-3p	RNA-RNA	regulation	N/A	The periostin expression was positively correlated with the expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and negatively correlated with the expression of microRNA (miR)-202-3p in CC tissues.	30633360
miR-203	RNA-RNA	regulation	N/A	LncRNA MALAT1 inhibition re-sensitized TMZ resistant cells through up-regulating miR-203 and down-regulating TS expression.	28187000
miR-203a	RNA-RNA	binding	N/A	MALAT1 was confirmed to function as a competing endogenous RNA (ceRNA), interacting with miR-125b and miR-203a.	31557499
miR-203a-3p	RNA-RNA	binding	N/A	Dual-luciferase reporter assay showed that miR-203a-3p could bind to the predicted seed regions of MALAT1 as evidenced by the reduced luciferase activity.	31689123
miR-204	RNA-RNA	binding	N/A	MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204	27294002
miR-204	RNA-RNA	binding	luciferase reporter assay	MALAT1 could directly interact with miR-204 and overexpression of miR-204 efficiently reversed the upregulation of Smad4 induced by MALAT1	28522163
miR-204	RNA-RNA	binding	N/A	NF-κB transcriptionally regulates MALAT1, which, by binding with miR-204 and releasing ZEB1, promotes the EMT.	31042084
miR-204	RNA-RNA	regulation	western blot	MALAT1 inhibited microRNA (miR)-204 expression in GC cells.	31897197
miR-205	RNA-RNA	regulation	N/A	MiR-205 was suppressed by MALAT1 in osteosarcoma and this interaction between miR-205 and MALAT1 has reciprocal effects.	29290978
miR-205-5p	RNA-RNA	binding	N/A	MALAT1 functions as a sponge RNA for miR-205-5p to increase therapeutic effects of MSCs on DF.	31866580
miR-205-5p	RNA-RNA	binding	western blot	MALAT1 acted as a competing endogenous RNA (ceRNA) of miR-205-5p via direct bonding with each other in HBMECs under OGD/R damage	32217110
miR-206	RNA-RNA	binding	N/A	Malat1 is overexpressed in gallbladder cancer (GBC) tissue and cells. The high Malat1 levels correlated positively with tumor size and lymphatic metastasis, and correlated negatively with overall survival. We also show that Malat1 functions as a competing endogenous RNA (ceRNA) for miR-206. Because miR-206 directly suppresses expression of ANXA2 and KRAS, which are thought to promote GBC progression, Malat1 binding of miR-206 in GBC tissue and cells has an oncogenic effect. Conversely, Malat1 knockdown inhibits proliferation and invasion by GBC cells while increasing apoptosis. In vivo, silencing Malat1 decreases tumor volume.	27191262
miR-206	RNA-RNA	binding	N/A	miR-206 was confirmed as a direct target of MALAT1.	31774373
miR-206	RNA-RNA	binding	western blot	MALAT1 directly targeted and inhibited the expression of miR-206, and VEGFA was predicted to be the target gene for miR-206.	32084582
miR-20a	RNA-RNA	binding	luciferase reporter assay, RIP, western blot	MALAT1 enhances inflammatory cytokine production through sponging miR-20a and releasing TLR4, indicating a regulatory role of MALAT1 in periodontal inflammation.	31552681
miR-20b-5p	RNA-RNA	binding	N/A	MALAT1 silencing downregulated the expression of ATP-binding cassette transporters (ABC), breast cancer resistance protein (BCRP), and multi-drug resistance proteins including MDR1 and MRP1, resulting in decreased resistance of cancer cells to 5-FU. In addition, the metastasis and invasion of HCT-116 and HCT-116/5-FU cells were regulated via targeting miR-20b-5p.	30716387
miR-20b-5p	RNA-RNA	binding	western blot, luciferase reporter assay	MALAT1 directly binds to miR-20b-5p and functions as a ceRNA for miR-20b-5p to regulate beclin1.	31823095
miR-20b-5p	RNA-RNA	binding	luciferase reporter assay	MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells.	32336590
miR-211	RNA-RNA	binding	N/A	MALAT1 could sponge miR-211 as a competing endogenous RNA and potentially up-regulate PHF19 expression, thus facilitating the OC progression.	29874124
miR-214	RNA-RNA	binding	N/A	MALAT1 positively regulates the expression of TRPV4 by sponging miR-214.	29870987
miR-214	RNA-RNA	binding	N/A	MALAT1 directly sponged miR-214 and miR-214 directly targeted ATF4.	31678133
miR-216a	RNA-RNA	binding	N/A	MiR-216a overexpression had similar effects as MALAT1 siRNA on restoring p21 and p27 expression and inhibiting B-MYB, RAF1 and PCNA1 expression in both PANC-1 and BxPC3 cells	28034748
miR-216a-5p	RNA-RNA	binding	luciferase reporter assay, western blot, RIP	MALAT1 directly binded to miR-216a-5p and MALAT1 enhanced Beclin-1 expression by sponging miR-216a-5p.	31029709
miR-216b-5p	RNA-RNA	binding	luciferase reporter assay	Knockdown of MALAT1 resulted in an increase of miR-216b-5p and a decrease of PNPO mRNA, indicating a regulatory mechanism of competing endogenous RNAs.	30982780
miR-217	RNA-RNA	regulation	N/A	A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues.	25538231
miR-217	RNA-RNA	binding	RIP	MALAT1 was physically associated with miR-217 and might function in the regulation of ZEB-1, further enhancing the expression of TERT so as to augment telomerase activity.	30658864
miR-218	RNA-RNA	binding	N/A	Being specifically upregulated in choriocarcinoma cell lines, the under-researched lncRNA-MALAT1 promoted choriocarcinoma cell growth by targeting miR-218.	29096355
miR-22	RNA-RNA	binding	N/A	We determined that MALAT1 promotes melanoma cells proliferation, invasion and migration by sponging miR-22.	27564100
miR-22-3p	RNA-RNA	binding	western blot, luciferase reporter assay	MiR-22-3p was a target of MALAT1 and that miR-22-3p inhibitor abolished the effect of MALAT1 shRNA on cell proliferation, migration and inactivation of PI3K/AKT pathway.	30431104
miR-22-3p	RNA-RNA	binding	N/A	MALAT1 negatively regulated its target miR-22-3p.	32021298
miR-22-3p	RNA-RNA	binding	western blot, RIP	miR-22-3p was a target miRNA of MALAT1 and ZFP91 was a target mRNA of miR-22-3p.	32104001
miR-23b-3p	RNA-RNA	regulation	N/A	Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer.	29162158
miR-25	RNA-RNA	binding	N/A	RNA-binding protein 24 (RBM24) was frequently downregulated in nasopharyngeal carcinoma (NPC). The restoration of RBM24 expression suppressed NPC cellular proliferation, migration and invasion and impeded metastatic colonization in mouse models. miR-25 expression was upregulated by RBM24 expression in NPC cells. Similarly, ectopic miR-25 expression suppressed NPC cellular growth and motility by targeting the pro-oncogenic lncRNA MALAT1, and the knockdown of MALAT1 expression exhibited similar effects as RBM24 restoration in NPC cells.	27584791
miR-26a	RNA-RNA	binding	ELISA, luciferase reporter assay, western blot	MALAT1 specifically binds to miR-26a and observed a reciprocal negative regulatory relationship between these factors.	31123414
miR-26a	RNA-RNA	binding	western blot	The invasive and metastatic abilities of primary CRC cells were enhanced after exposure to exosomes derived from highly metastatic CRC cells, which increased the fucosyltransferase 4 (FUT4) levels and fucosylation not by directly transmitting FUT4 mRNA. Exosomal MALAT1 increased FUT4 expresssion via sponging miR-26a/26b. Furthermore, MALAT1/miR-26a/26b/FUT4 axis played an important role in exosome-mediated CRC progression.	32209115
miR-26b	RNA-RNA	binding	N/A	Malat1 served as an endogenous sponge to downregulate miR-26b expression by binding directly to miR-26b	28433650
miR-30	RNA-RNA	binding	N/A	MiR-30 is a potential target of lncRNA MALAT1 and Runx2 is a potential target of miR-30.	30511267
miR-3064-5p	RNA-RNA	binding	N/A	MALAT1 functioned as a competing endogenous RNA (ceRNA) by sponging miR-3064-5p to alleviate the suppressive effect on the FOXA1 pathway.	31914639
miR-30a	RNA-RNA	regulation	N/A	Our study first revealed that down-regulation of MALAT1 attenuated neuronal cell death through suppressing Beclin1-dependent autophagy by regulating miR-30a expression in cerebral ischemic stroke. Besides, our study demonstrated a novel lncRNA-miRNA-mRNA regulatory network that is MALAT1-miR-30a-Beclin1 in ischemic stroke, contributing to a better understanding the pathogenesis and progression of ischemic stroke.	28854438
miR-30a	RNA-RNA	binding	western blot	LncRNA-MALAT1 up-regulates the expression of BECN1 by binding to miR-30a, thereby increasing the level of cell autophagy after MI.	32016995
miR-30a-5p	RNA-RNA	binding	western blot	MALAT1 could competitively sponge miR-30a-5p and thereby regulate Vimentin	30278452
miR-30b	RNA-RNA	binding	N/A	MALAT1 inhibited miR-30b expression by direct interaction. Moreover, miR-30b abolished MALAT1-induced CDDP resistance by inhibiting autophagy in AGS/CDDP and HGC-27/CDDP cells. Furthermore, ATG5 was found to be a target of miR-30b. miR-30b weakened resistance to CDDP by inhibiting autophagy in AGS/CDDP and HGC-27/CDDP cells, while this effect was abrogated by increased ATG5 expression.	30365113
miR-30c	RNA-RNA	binding	western blot	MALAT1 promoted NLRP3 expression by sponging miR-30c through dual-luciferase reporter assay.	32391974
miR-30e	RNA-RNA	binding	luciferase reporter assay, western blot	MALAT1 could bind with miR-30e to regulate ATG5 expression, thus causing the suppression of autophagy.	31926239
miR-320a	RNA-RNA	binding	N/A	MALAT1 was shown to reciprocally interact with miR-320a, i.e., expression of one negatively regulated levels of the other, whereas knockdown of MALAT1 expression promoted miR-320a levels. Furthermore, miR-320a could directly target and inhibit FOXM1 expression in HUVECs. Knockdown of MALAT1 expression enhanced miR-320a expression but reduced FOXM1 expression resulting in downregulation of HUVEC proliferation. However, such an effect was inhibited by miR-320a depletion.	28977880
miR-320a	RNA-RNA	regulation	RIP	MALAT1 also reduced miR-320a levels in HUVECs. miR-320a inhibition alleviated H/R-stimulated HUVEC injury via RAC1.	31408432
miR-320b	RNA-RNA	binding	N/A	MALAT1 bound to miR-320b and negatively regulated its expression, and vice versa. AR is a target of miR-320b. The phenotypic changes induced by silencing of MALAT1 were abolished by miR-320b inhibition or AR overexpression.	30642743
miR-335-3p	RNA-RNA	binding	N/A	Negative correlations were identified between the expression levels of miR-335-3p and the selected LncRNAs, NEAT1 and MALAT1, in the MDR group compared with the mrd- patients (P = 0.009), suggesting a sponge effect for these LncRNAs.	30639603
miR-338-3p	RNA-RNA	binding	N/A	MALAT-1 competed for binding to miR-338-3p with male-specific lethal 2 (MSL2). MALAT-1 directly induced MSL2 expression in MG by acting as a competing endogenous RNA for miR-338-3p	30362606
miR-338-3p	RNA-RNA	regulation	western blot	LncRNA MALAT1 induced the upregulation of CRP expression through inhibiting the expression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p.	31342266
miR-339-5p	RNA-RNA	binding	N/A	LncRNA MALAT1 can regulate BLCAP mRNA expression through binding to miR-339-5p.	30683807
miR-34a	RNA-RNA	regulation	N/A	Knockdown of MALAT1 inhibits osteosarcoma progression via regulating the miR-34a/cyclin D1 axis.	30365098
miR-34a	RNA-RNA	binding	N/A	MALAT1 could be shown to regulate c-Myc and Met expression by functioning as a miR-34a sponge.	31101802
miR-34a/c-5p	RNA-RNA	binding	western blot	Further study showed a positive correlation between MALAT1 and c-Met or SOX4 expression. MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b.	30793707
miR-363-3p	RNA-RNA	binding	western blot, immunofluorescence assay	MALAT1 regulated Myeloid cell leukaemia-1 (MCL-1) expression as a competing endogenous RNA (ceRNA) for miR-363-3p in GBC cells.	27420766
miR-363-3p	RNA-RNA	binding	N/A	MALAT1 is a negative regulator of Mcl1 mRNA by sponging of miR-363-3p.	31077090
miR-374b-5p	RNA-RNA	binding	western blot	Then, we identified that miR-374b-5p was a target of MALAT1 and SRSF7 was the downstream of miR-374b-5p.	32141554
miR-375	RNA-RNA	binding	N/A	MALAT1 modulates the cell proliferation, apoptosis, migration and invasion via directly interact with miR-383, miR-15, miR-205 and miR-375. By modulating the VEGFA expression, MALAT1 controls the capillary formation of HUVEC cells.	30173780
miR-376a	RNA-RNA	binding	N/A	There was a direct interaction between MIR376A and MALAT1 via a putative MIR376A binding site within the MALAT1 3'-untranslated region (3'-UTR). There was also a direct interaction between MIR376A and the TGFA 3'-UTR.	27458156
miR-383	RNA-RNA	binding	N/A	MALAT1 modulates the cell proliferation, apoptosis, migration and invasion via directly interact with miR-383, miR-15, miR-205 and miR-375. By modulating the VEGFA expression, MALAT1 controls the capillary formation of HUVEC cells.	30173780
miR-384	RNA-RNA	binding	western blot, RIP	MiR-384 was a target of MALAT1, and miR-384 inhibition reversed the effects of MALAT1 knockdown in glioma cells.	32196610
miR-424	RNA-RNA	binding	western blot	Knockdown of MALAT1 suppressed the expression of MEKK3 and inactivated the IKK/NF-κB pathway by sponging miR-424.	31610202
miR-425	RNA-RNA	binding	N/A	MALAT1 interacted with miR-425 and protected phosphatase and tensin homolog (PTEN) expression in A549 and HFL-1 cells.	31871512
miR-425-5p	RNA-RNA	binding	N/A	MiR-425-5p upregulation decreased the expressions of MALAT1 and TUG1 in OS cells via direct binding them. miR-425-5p upregulation strikingly abrogated the activation of Wnt/β-catenin signaling pathway induced by MALAT1 and TUG1 overexpression in OS cells.	30986552
miR-449a	RNA-RNA	binding	western blot	Further study showed a positive correlation between MALAT1 and c-Met or SOX4 expression. MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b.	30793707
miR-449a/b	RNA-RNA	binding	western blot	Further study showed a positive correlation between MALAT1 and c-Met or SOX4 expression. MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b.	30793707
miR-449b	RNA-RNA	binding	western blot	Further study showed a positive correlation between MALAT1 and c-Met or SOX4 expression. MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b.	30793707
miR-483-3	RNA-RNA	regulation	western blot	LncRNA MALAT1 induced the upregulation of CRP expression through inhibiting the expression of hsa-miR-145-5p, hsa-miR-140-5p, hsa-miR-483-3p, and hsa-miR-338-3p.	31342266
miR-485-3p	RNA-RNA	binding	western blot	The hsa-miR-539-3p and hsa-miR-485-3p were targets of MALAT1, and BMPR2 was the target of hsa-miR-539-3p and hsa-miR-485-3p	32109146
miR-497	RNA-RNA	binding	western blot	MALAT1 improved NRCMs survival and HUVEC tube formation through targeting miR-497.	32393784
miR-503	RNA-RNA	binding	N/A	The up-regulated lncRNA Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), acted as a competing endogenous RNA (ceRNA), can directly bound to miR-503, which indicated that lncRNA MALAT1 may modulate the expression of miR-503 thus triggering the activation of downstream fibrotic signaling pathways.	28900284
miR-503	RNA-RNA	binding	western blot	Our molecular study further demonstrated that MALAT1 could sponge miR-503, modulate the expression of miR-503	32228440
miR-506	RNA-RNA	binding	N/A	LncRNA-MALAT1 was specifically upregulated ovarian cancer cell lines and promoted ovarian cancer-cell growth through targeting microRNA (miR)-506.	28031721
miR-509	RNA-RNA	binding	N/A	MiR-509 is a direct target of MALAT1 and Ras-related C3 botulinum toxin substrate 1 (Rac1) is a direct target of miR-509. MALAT1 may promote OS cell growth through inhibition of miR-509, leading to the activation of Rac1/JNK pathway.	28560950
miR-509-5p	RNA-RNA	binding	N/A	MALAT1 was identified to function as a competitive endogenous RNA (ceRNA) for miR-509-5p to promote MM cell viability.miR-509-5p targeted the 3'-UTR of FOXP1 to suppress MM cells progression	29254219
miR-539-3p	RNA-RNA	binding	western blot	The hsa-miR-539-3p and hsa-miR-485-3p were targets of MALAT1, and BMPR2 was the target of hsa-miR-539-3p and hsa-miR-485-3p	32109146
miR-608	RNA-RNA	binding	N/A	MALAT1 could upregulate the HOXC4 by binding to miR-608.	31913701
miR-625-5p	RNA-RNA	binding	N/A	Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion in cervical cancer by targeting miR-625-5p and AKT2.	32009350
miR-625-5p	RNA-RNA	binding	western blot	The regulatory effects of miR-625-5p on NF-κB and MALAT1 were interrogated by luciferase reporter assay.	32152961
miR-663a	RNA-RNA	binding	N/A	The RNA-pulldown results showed MALAT1 lncRNA-miR663a binding	30154407
miR-92a	RNA-RNA	regulation	N/A	Silencing MALAT1 by MALAT1 siRNA significantly inhibited KLF2 mRNA expression induced by HBO, as did MiR-92a.	30301563
miR-92a-3p	RNA-RNA	binding	N/A	LncRNA-MALAT1 that functioned as ceRNA binding to miR-92a-3p, leading to ATG4a activation, thus improving mitochondrial metabolism.	32384281
miR-c-5p	RNA-RNA	binding	western blot	Further study showed a positive correlation between MALAT1 and c-Met or SOX4 expression. MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b.	30793707
MIT	RNA-Protein	binding	N/A	Co-silencing of Sp1 and Sp3 synergistically repressed MALAT1 expression. Sp1 binding inhibitor, mithramycin A (MIT), also inhibited MALAT1 expression in HCC cells.	26352013
NF-κB	RNA-Protein	regulation	N/A	Mechanistically, MALAT1 was found to interact with NF-κB in the nucleus, thus inhibiting its DNA binding activity and consequently decreasing the production of inflammatory cytokines.	27434861
NF-κB	DNA-TF	regulation	N/A	NF-κB transcriptionally regulates MALAT1, which, by binding with mir-204 and releasing ZEB1, promotes the EMT.	31042084
NF-κB	RNA-Protein	regulation	western blot	Transfection of MALAT1 siRNA suppressed its expression in endometrial cells, inhibited cell proliferation or invasion, enhanced caspase 3 activity, decreased NF-κB/iNOS or MMP-9 expression	31173276
NRF1	DNA-TF	regulation	western blot	Indeed, using a ChIP assay, we observed significant enrichment of NRF1 at MALAT1 promoter	29487387
NRF2	RNA-Protein	regulation	N/A	LV-MALAT1 induced Keap1 downregulation, leading to nuclear-factor-E2-related factor 2 (Nrf2) stabilization and activation.	29274336
NRF2	RNA-Protein	regulation	N/A	exosomes from ox-LDL-treated MALAT1-overexpressing-HUVECs (ox-LDL-HUVECs-ExosLv-MALAT1) released elevated expression of MALAT1 to iDCs, which interacted with NRF2 and activated NRF2 signaling	31305205
NSPc1	RNA-Protein	binding	RIP	MALAT1, SOX2OT and ANRIL bind to NSPc1 in U87 glioblastoma cells and the enrichment of ANRIL in anti-NSPc1 antibody group was associated with the expression levels of NSPc1 during U87 cell differentiation.	31186810
Oct4	DNA-TF	regulation	N/A	Our study reveals a novel mechanism by which Oct4 transcriptionally activates NEAT1 via promoter and MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.	28615056
p21	RNA-DNA	co-expression	N/A	The increased expression of p21 and p27 upon MALAT1 knockdown was regulated by enhancer of zeste homolog 2 (EZH2).	27998273
p27	RNA-DNA	regulation	N/A	The increased expression of p21 and p27 upon MALAT1 knockdown was regulated by enhancer of zeste homolog 2 (EZH2).	27998273
p300	RNA-Protein	binding	N/A	silencing of MALAT1 inhibited the chemotaxis of neutrophils by downregulating IL-8 expression via binding to p300.	31604167
p38	RNA-Protein	regulation	western blot	MALAT1 may participate in UVB-induced photo-aging via regulation of the ERK/mitogen-activated protein kinase signaling pathway and UVB-induced MALAT1 expression is independent of ROS generation.	28487970
p38	RNA-Protein	regulation	N/A	MALAT-1 can promote the apoptosis and oxidative stress of PC12 cells by activating p38MAPK pathway, thus aggravating the damage of PC12 cells induced by chemical hypoxia.	29360503
p53	DNA-TF	regulation	N/A	Our results highlight a key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins.	28652379
PARP1	RNA-Protein	binding	N/A	MM express elevated MALAT1 and involve in alternative non-homozygous end joining (A-NHEJ) pathway by binding to PARP1 and LIG3, two key components of the A-NHEJ protein complex.	29632340
periostin	RNA-Protein	regulation	N/A	The periostin expression was positively correlated with the expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and negatively correlated with the expression of microRNA (miR)-202-3p in CC tissues.	30633360
PRC2	RNA-Protein	binding	N/A	Mechanistically, through an association with chromatin modulator polycomb repressive complex 2 (PRC2), MALAT1 detached the core component enhancer of zeste homolog 2 (EZH2) from binding with HIV-1 LTR promoter, and thus removed PRC2 complex-mediated methylation of histone H3 on lysine 27 (H3K27me3) and relieved epigenetic silencing of HIV-1 transcription.	30788509
pre-mRNA splicing factors	RNA-Protein	binding	N/A	MALAT1 interacts with pre-mRNA splicing factors and regulates cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation.	23698766
RET	RNA-Protein	regulation	N/A	MALAT1 expression was positively related to RET and negatively related to miR-129-5p in osteosarcoma samples and xenograft tumors.	30481748
SFPQ	RNA-Protein	binding	N/A	Furthermore, MALAT1 directly binds to SFPQ (Splicing Factor Proline and Glutamine Rich) protein, indicating its multifaceted roles in ACC pathophysiology.	31085769
SIRT1	RNA-DNA	binding	western blot, ELISA	Interaction between MALAT1 and Foxo1 was observed in HK-2 cells and the interaction was promoted by high glucose treatment. Foxo1 activated SIRT1 transcription by binding to its promoter, and MALAT1 repressed SIRT1 expression through targeting Foxo1.	29928873
SOX2	RNA-RNA	binding	N/A	MALAT1 directly binds to sox2 mRNA (which encodes a critical master pluripotency factor), enhances the mRNA stability and increases its expression; KD of sox2 partially reversed the effect of MALAT1 OE on the stemness of gastric cancer cells.	31037832
SOX9	RNA-Protein	binding	western blot	Moreover, the results of the bioinformatics prediction and luciferase assays demonstrated that MALAT1 directly interacted with SRY‑box 9 (SOX9).	32124944
SP1	RNA-TF	binding	ELISA	lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoterto increase expression of LTBP3 gene.	25187517
SP1	RNA-Protein	binding	RIP	Malat1 M5 interacts with the C-terminal domain of SP1. Malat1-SP1 association results in increase of SP1 stability. In turn, SP1 promotes malat1 transcription, thus forming a positive feedback loop.	29575609
SPRR proteins	RNA-Protein	regulation	N/A	Several members of small proline rich proteins (SPRR) were up-regulated by KD of MALAT-1 lncRNA in TSCC cells. SPRR2A over-expression could impair distant metastasis of TSCC cells in-vivo.	27586393
SR	RNA-Protein	binding	N/A	MALAT1 interacts with SR proteins and influences the distribution of these and other splicing factors in nuclear speckle domains.	20797886
SRSF1	RNA-TF	binding	N/A	In this study, we demonstrate that oncogenic splicing factor SRSF1 bridges MALAT1 to mutant p53 and ID4 proteins in breast cancer cells.	28652379
SRSF2	RNA-TF	binding	N/A	MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2) to promote alternative splicing of PKCδII.	27841943
STAT3	DNA-Protein	binding	N/A	With luciferase reporter assays, a STAT3-binding sequence in the enhancer region of MALAT1 gene was demonstrated to be crucial for the IL-6- or STAT3-induced MALAT1 promoter activation.	32113834
STAT3.43	RNA-RNA	binding	N/A	However, recent evidence has demonstrated that lncRNAs can serve as sponges to titrate microRNAs (miRNAs) and prevent them from binding to mRNAs by acting as competing endogenous RNAs (ceRNAs).44 In the development of non‐small cell lung cancer (NSCLC), previous studies have uncovered that MALAT1 can act as a ceRNA to modulate miR124/STAT3.43	30784209
SUZ12	RNA-Protein	binding	western blot	MALAT1 directly binds to EZH2 and SUZ12, and BMI1 activation may be induced possibly through H3K27me3.	28412742
TCF7L2	RNA-TF	regulation	N/A	MALAT1 upregulated the expression of glycolytic genes and downregulated gluconeogenic enzymes by enhancing the translation of the metabolic transcription factor TCF7L2.	30914432
TDP-43	RNA-Protein	binding	N/A	TDP-43 directly bound to MALAT1 RNA. Silencing TDP-43 expression effectively decreased MALAT1 RNA transcript level. In contrast, TDP-43 overexpression markedly increased MALAT1 transcript level.	26265046
TEAD	RNA-Protein	binding	N/A	MALAT1 lncRNA binds and inactivates the prometastatic transcription factor TEAD, preventing TEAD from associating with its co-activator YAP and target gene promoters.	30349115
TFAP2C	RNA-Protein	binding	N/A	TFAP2C-activated MALAT1 modulated the chemoresistance of LUAD cells by sponging miR-200b to upregulate E2F3 and ZEB1.	30771618
TGF-β	RNA-Protein	regulation	N/A	MALAT1 may function both as an oncogene and as a tumor suppressor in different types of thyroid tumors.	27696303
TXNIP	RNA-Protein	regulation	N/A	For β-cells (MIN6), cigarette smoke extract (CSE) increased the levels of thioredoxin-interacting protein (TXNIP) and the long noncoding (lnc)RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and downregulated the levels of the transcription factor, mafA, and microRNA (miR)-17.	29856480
UPF1	RNA-Protein	regulation	N/A	UPF1 is a potential modulator of MALAT1 and that UPF1/MALAT1 pathway could be a therapeutic target for gastric cancer.	28942451
VE-cadherin	RNA-Protein	regulation	N/A	MALAT1 can promote tumorigenicity and metastasis in GC by facilitating VM and angiogenesis via the VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways	28268166
YAP	RNA-Protein	binding	N/A	MALAT1 binds directly to Yes-associated protein (YAP), thereby enhancing YAP protein expression and increasing YAP transcriptional activity.	31116509
β-catenin	RNA-Protein	binding	N/A	OxLDL induced MALAT1 transcription and MALAT1 recruits β-catenin to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages.	29258822

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