LncRNA Information
ID	EL2066	Name	lncRNA:roX2	Aliases	Dmel_CR32665, CR32665, Dmel\CR32665, RoX2, lncRNA-roX2, roX, roX2, roX2-lncRNA, rox2
Species	Drosophila melanogaster	Chromosome	X	Start site	11579065
End site	11580432	Chain	plus	Exon NO.	1
Assembly	Release 6 plus ISO1 MT	Class	lncRNA	NCBI accession	NR_002104, NR_002105, NR_047796, NR_047795, NR_123871, NR_123872
Ensembl	N/A	Sequence	NR_002104 NR_002105 NR_047796 NR_047795 NR_123871 NR_123872	Peptide-related	N/A
CircRNA	N/A	Exosomal	N/A	Structure	yes

Structure information
Structure view	PDB ID
	5ZTM
	6I3R

Function (not disease relevant)
Drug/chemo/stress	Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID
	RNA immunoprecipitation, Immunoblotting and immunostaining of chromosomes, Fluorescent polarization assays, Electrophoretic mobility shift assays	Drosophila, S2 cell lines		interaction	Our research provides structural insights into the interactions between MLE dsRBDs and R2H1 and facilitates a deeper understanding of the mechanism by which MLE tandem dsRBDs play an indispensable role in specific recognition of roX and the assembly of theMSL-DCC inDrosophila dosage compensation	30649456
	N/A	N/A	N/A	mutation	Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions.	26773003
	loss-of-function, knockdown,		down-regulated	expression	RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.	30532158
	Protein clonin, NMR	Drosophila S2 cells			dsRBD1 mutants in which dsRNA binding in vitro is strongly compromised do not affect roX2 RNA binding and MLE localization in cells	30805612

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
MLE	RNA-Protein	binding	N/A	MLE dsRBDs bind to R2H1 cooperatively and interact with two successive minor grooves and a major groove of R2H1, respectively.	30649456

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