| Disease |
| Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
| mantle cell lymphoma |
|
qRT-PCR,ELISA, western blot, Knockdown, overexpression, |
plasma of patients with mantle cell lymphoma and healthy controls |
up-regulated |
interaction |
LINK-A lncRNA Promotes Proliferation and Inhibits Apoptosis of Mantle Cell Lymphoma Cell by Upregulating Survivin. |
30636001 |
| glioma |
|
qRT-PCR, ELISA, knockdown, overexpression |
glioma cells |
up-regulated |
interaction |
LINK-A lncRNA participates in the pathogenesis of glioma by interacting with survivin. |
31410112 |
| hepatocellular carcinoma |
|
knockdown, luciferase |
HCC specimens and cell lines |
up-regulated |
interaction |
LINC01139 may exhibit an oncogenic function in HCC via acting as a sponge for miR-30 to upregulate MYBL2, and may serve as a potential therapeutic target and a prognostic biomarker for HCC patients. |
32115147 |
| hereditary haemorrhagic telangiectasia |
|
N/A |
N/A |
N/A |
expression |
Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. |
24603890 |
| triple-negative breast cancer |
|
N/A |
N/A |
N/A |
expression |
Both LINK-A expression and LINK-A-dependent signalling pathway activation correlate with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis. |
26751287 |
| glioma |
|
Knockdown |
human glioma cells compared with normal astrocytes, U87 and U251 glioma cells |
up-regulated |
expression/mutation |
We demonstrated that LINK-A was upregulated in human glioma cells compared with the expression noted in normal astrocytes. Knockdown of LINK-A inhibited cell proliferation, migration and invasion in U87 and U251 glioma cells |
28714007 |
| ovarian carcinoma |
|
qRT-PCR, ELISA, overexpression, western blot |
ovarian biopsies and plasma, human ovarian carcinoma cell lines |
up-regulated |
expression |
LINK-A lncRNA may promote migration and invasion of ovarian carcinoma cells by activating TGF-β pathway. |
30061183 |
| non-small cell lung cancer |
|
qRT-PCR, knockdown, western blot |
NSCLC tissues and cell lines, normal tissues |
up-regulated |
expression |
LINK-A promotes cell proliferation through the regulation of aerobic glycolysis in non-small-cell lung cancer. |
30275711 |
| ovarian carcinoma |
|
qRT-PCR, overexpression |
ovarian biopsies, serum |
up-regulated |
expression |
LINK-A Long Non-Coding RNA (lncRNA) Participates in Metastasis of Ovarian Carcinoma and Upregulates Hypoxia-Inducible Factor 1 (HIF1α). |
30912527 |
| osteosarcoma |
|
overexpression |
osteosarcoma cell line |
up-regulated |
expression |
LINK-A lncRNA functions in the metastasis of osteosarcoma by upregulating HIF1α. |
31186711 |
| diabetic nephropathy |
high glucose |
qRT-PCR, overexpression, western blot, ELISA, |
in renal biopsies of patients with diabetic nephropathy. |
down-regulated |
expression |
LINK-A lncRNA activates HIF1α signaling and inhibits podocyte cell apoptosis in diabetic nephropathy. |
31258644 |
| diabetic nephropathy |
high glucose |
qRT-PCR, overexpression, western blot, ELISA, |
mouse podocyte cells under a high glucose treatment |
down-regulated |
expression |
LINK-A lncRNA activates HIF1α signaling and inhibits podocyte cell apoptosis in diabetic nephropathy. |
31258644 |
| non-small cell lung cancer |
|
qRT‑PCR, western blot |
plasma, NSCLC cell lines |
up-regulated |
expression |
LINK-A is overexpressed in metastatic NSCLC, and may promote the migration and invasion of NSCLC by activating Akt signaling. |
31404323 |
