LncRNA Information
ID EL0717 Name CRNDE Aliases CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5
Species Homo sapiens Chromosome 16 Start site 54918863
End site 54928886 Chain minus Exon NO. 7
Assembly GRCh38.p13 Class lincRNA NCBI accession NR_034105, NR_110453, NR_110454, NR_034106
Ensembl N/A Sequence NR_034105 NR_110453 NR_110454 NR_034106 Peptide-related yes
CircRNA N/A Exosomal N/A Structure N/A




Disease
Disease Drug/chemo/stress Method Sample Expression pattern Dysfunction type Description PMID
gallbladder carcinoma qRT-PCR, Knockdown normal tissues and GBC cancer tissues down-regulated interaction Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway. 27637083
colorectal cancer qRT-PCR, fluorescence reporter, western blot, knockdown CRC tissues and cell lines up-regulated interaction CRNDE could regulate the progression and chemoresistance of CRC via modulating the expression levels of miR-181a-5p and the activity of Wnt/β-catenin signaling 28086904
colorectal cancer knockdown, overexpression primary specimens from colorectal cancer patients and colorectal cancer cell lines up-regulated interaction CRNDE functions as a competing endogenous RNA to promote metastasis and OXA resistance by sponging miR-136 in colorectal cancer 28115855
colorectal carcinoma western blot, luciferase activity assay, olorectal cancer tissues and cells up-regulated interaction The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway. 28472810
gastric cancer qRT-PCR, western blot, luciferase reporter assay, up-regulated interaction CRNDE acted as a growth-promoting lncRNA in GC and maybe a potential target of GC treatment. 28490034
lung adenocarcinoma LAD tissue and radio-resistant LAD cell lines up-regulated interaction High level of CRNDE expression was significantly correlated with poor differentiation, TNM stage and lymph node metastasis, radiotherapy response and high level of CRNDE expression had a significantly shorter overall survival. 28550688
colorectal carcinoma qRT-PCR, situ hybridization colorectal carcinoma (CRC) tissues and cells up-regulated interaction Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways 28594403
colorectal cancer knockdown, RNA immunoprecipitation,chromatin RNA immunoprecipitation assays CRC tissues up-regulated interaction Evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in the regulation of tumor cellular processes, such as proliferation, apoptosis, and metastasis. LncRNA CRNDE (Colorectal Neoplasia Differentially Expressed) is located at human chromosome 16 and has been found overexpressed in a variety of cancers including colorectal cancer (CRC). 28796262
glioma glioma cell lines down-regulated interaction CRNDE functions as a competing endogenous RNA (ceRNA) that binds to and negatively regulates miR-136-5p, thereby protecting Bcl-2 and Wnt2 from miR-136-5p-mediated inhibition in glioma. 29152149
hepatocellular carcinoma Microarray, qRT-PCR, western blot, dual luciferase assay, Knockdown, overexpression HCC cancerous tissues and adjacent tissues up-regulated interaction LncRNA CRNDE could enhance HCC tumorgenesis by sponging miR-203 and mediating BCAT1. LncRNA CRNDE might facilitate HCC cell propagation, invasiveness, and migration through regulating miR-203/ BCAT1 axis. 30230527
melanoma microarray, overexpression melanoma tissues and cell lines up-regulated interaction The long non-coding RNA CRNDE competed endogenously with miR-205 to promote proliferation and metastasis of melanoma cells by targeting CCL18. 30257602
non-small cell lung cancer qRT-PCR, knockdown, luciferase reporter,RNA immunoprecipitation NSCLC tissues and cell lines up-regulated interaction Long noncoding RNA CRNDE promotes non-small cell lung cancer progression via sponging microRNA-338-3p. 30554121
non-small cell lung cancer qRT-PCR, mimic, luciferase reporter assay, western blot, knockdown NSCLC cells up-regulated interaction LncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) Promotes Proliferation and Inhibits Apoptosis in Non-Small Cell Lung Cancer Cells by Regulating the miR-641/CDK6 Axis. 30982057
hepatocellular carcinoma qRT-PCR, western blot, RNA pull-down, luciferase,western blot tumor tissues, mouse model up-regulated interaction LncRNA CRNDE promotes hepatocellular carcinoma progression by upregulating SIX1 through modulating miR-337-3p. 31099050
inflammatory bowel disease dextran sulfate sodium (DSS) RIP, RNA pull-down, luciferase reporter assay mouse model, human colonic epithelial cell lines, colitis tissues up-regulated interaction Long non-coding RNA CRNDE promotes cell apoptosis by suppressing miR-495 in inflammatory bowel disease. 31251902
liver cancer overexpression, knockdown HepG2/ADM and BEL-7402/ADM cell lines up-regulated interaction downregulated CRNDE could upregulate miR-33a and inhibit HMGA2 expression, thus significantly promotes apoptosis of liver cancer cells and inhibiting its proliferation, migration, invasion and drug resistance. 31416393
cervical cancer qRT-PCR, western blot, knockdown, luciferase reporter assay, mimic CC tissues and cells up-regulated interaction LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression. 31605132
pre-eclampsia qRT-PCR, western blot, Double Luciferase Report, overexpression, knockdown, HTR-8/Svneo cells, placental tissue, seroti cell, down-regulated interaction LncRNA CRNDE regulates trophoblast cell proliferation, invasion, and migration via modulating miR-1277. 31632559
medulloblastoma cisplatin knockdown, overexpression, Luciferase reporter assays, RIP, RNA pull-down, medulloblastoma cells, a xenograft mouse model of human medulloblastoma. up-regulated interaction Inhibition of Long Non-Coding RNA CRNDE Increases Chemosensitivity of Medulloblastoma Cells by Targeting MiR-29c-3p. 31753063
liver injury qRT-PCR, western blot, dual luciferase reporter assay, RIP, overexpression, knockdown Cecal ligation and perforation (CLP) models, hepatic epithelial cells L02 down-regulated interaction Downregulated CRNDE aggravates hepatic injury via regulating miR-126-5p and BCL2L2 during sepsis. 32031750
Wilms' tumor qRT-PCR, overexpression, knockdown, dual-luciferase tumor tissues of patients with Wilms' tumor up-regulated interaction CRNDE was highly expressed in Wilms' tumor tissue and cell lines. 32096178
prostate cancer qRT-PCR, dual-luciferase assay, overexpression, western blot PC3 and 22RV1 cells up-regulated interaction CRNDE contributed to cell proliferation, migration and invasion by regulating the miR-101/Rap1A axis in Pca, providing a novel strategy for Pca treatment. 32182086
hepatoblastoma dual luciferase assay, western blot, qRT-PCR, overexpression HB tissues down-regulated interaction lncRNA CRNDE targets the miR-203/VEGFA axis and promotes angiogenesis in HB. 32182608
abdominal aortic aneurysm AngII overexpression AAA tissues and AngII-stimulated VSMCs down-regulated interaction LncRNA CRNDE affects the proliferation and apoptosis of vascular smooth muscle cells in abdominal aortic aneurysms by regulating the expression of Smad3 by Bcl-3. 32240036
hepatocellular carcinoma qRT-PCR, western blot, Dual luciferase, Immunofluorescence, RNA pulldown, Rescue experiments HCC cells and HCC tissues compared with normal cells and the corresponding adjacent normal tissues. up-regulated interaction lncRNA CRNDE promotes the expression of POU2F1 by adsorbing miR-539-5p, thus promoting the progression of HCC. 32252678
pneumonia qRT-PCR, luciferase reporter assay, RIP LPS-induced MRC-5 cells up-regulated interaction Long non-coding RNA (lncRNA) CRNDE regulated lipopolysaccharides (LPS)-induced MRC-5 inflammation injury through targeting miR-141. 32317619
colorectal cancer qRT-PCR CRC tissue up-regulated expression An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia. 22393467
colorectal cancer microarray, qRT-PCR, knockdown cell lines (HCT116, HT29, LS174T etc.) up-regulated N/A In colorectal cancer cells, we demonstrate that treatment with insulin and insulin-like growth factors (IGF) repressed CRNDE nuclear transcripts, including those encompassing gVC-In4. These repressive effects were negated by use of inhibitors against either the PI3K/Akt/mTOR pathway or Raf/MAPK pathway, suggesting CRNDE is a downstream target of both signaling cascades. 24184209
glioma qRT-PCR, western blot, ChIP, glioma tissue, cell lines(U87MG, U251) up-regulated expression Overexpression of specific CRNDE transcript promotes cell growth and migration in vitro while knockdown of CRNDE expression manifests a repressive function during these cellular processes. Mechanistic studies further revealed that histone acetylation in the promoter region might account for the upregulation of CRNDE, and the level of CRNDE expression could be modulated by mammalian Target of Rapamycin (mTOR) signaling in glioma. 25813405
colorectal cancer qRT-PCR 142 CRC tissues and 142 paired adjacent nontumorous tissues up-regulated N/A upregulation of lncRNA CRNDE-h was significantly correlated with large tumor size 27042112
renal cell carcinoma loss and gain function assays fresh RCC tissues and adjacent tissues up-regulated expression CRNDE promotes RCC cell proliferation and growth both in vitro and in vivo 27714674
glioma qRT-PCR glioma tissues up-regulated expression CRNDE upregulation was correlated with larger tumor size (p = 0.011), higher WHO grade (p = 0.001), and recurrence (p = 0.008). 27775801
hepatic carcinoma qRT-PCR hepatic carcinoma (HCC) tissues and cell lines up-regulated expression CRNDE promotes HCC cell proliferation, migration, and invasion in vitro 27822419
colorectal cancer serum of CRC patients up-regulated The increased expression of exosomal CRNDE-h was successfully validated in 148 CRC patients when compared with colorectal benign disease patients and healthy donors. 27888803
hepatoblastoma knockdown up-regulated CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. 28178668
breast cancer BC tissue specimens and cell, normal human breast epithelial cells up-regulated expression Long noncoding RNA CRNDE activates Wnt/β-catenin signaling pathway through acting as a molecular sponge of microRNA-136 in human breast cancer. 28469804
colorectal cancer qRT-PCR, NSCLC patients and cells up-regulated expression Recently, numerous studies have revealed that long non-coding RNAs (lncRNAs) play complex roles in various lung diseases, while the colorectal neoplasia differentially expressed (CRNDE) functions in non-small cell lung carcinomas (NSCLC) remain largely unknown. In the present study, we investigate the role and mechanism of CRNDE in the progression of NSCLC. The mRNA level of CRNDE in NSCLC patients and cells was detected by qRT-PCR. The influence of CRNDE silencing or over-expression on NSCLC cell proliferation and growth were assessed by MTT and flow cytometry, respectively. We also investigated the effect of abnormal CRNDE expression on cyclins and PI3K/AKT pathway. Furthermore, si-CRNDE NSCLC cell lines were injected subcutaneously into nude mice to explore tumour formation in vivo. The expression of CRNDE was significantly upregulated in NSCLC patients and cells. In addition, both loss and gain function assays revealed that CRNDE promoted NSCLC cell proliferation and growth both in vitro and in vivo. Moreover, CRNDE regulated the cell cycle transition from G0 /G1 stage to S stage and modulated the expression of CDK4, CDK6 and CCNE1. We further illustrated that CRNDE activated PI3K/AKT signalling in NSCLC cell lines. In conclusion, CRNDE was highly expressed in NSCLC malignant tissues and the heightened CRNDE strongly promoted NSCLC cell proliferation and growth through activating PI3K/AKT signalling; our results shed a light on utilizing CRNDE as a potential novel therapeutic target for the treatment of NSCLC. CRNDE promoted NSCLC cell proliferation and growth both in vitro and in vivo 28477368
glioma microarray, knockdown glioma patients cell up-regulated expression The aberrant expression of CRNDE may bemediated by activated EGFR signaling and play significant roles in gliomagenesis. 28493025
pancreatic cancer qRT-PCR, dual-luciferase reporter, knockdown pancreatic cancer cells, the adjacent non-tumour tissues and human pancreatic duct epithelial cells up-regulated expression High expression of CRNDE was correlated with poor clinicpathological characteristics and shorter overall survival. 28940804
colorectal carcinoma CRC cell lines up-regulated expression High CRNDE-p and low miR-217 serum exosomal levels correlated with advanced clinical stages (III/IV), tumor classification (T3/T4), and lymph node or distant metastasis. 29137379
cervical cancer microarray, qRT-PCR, cervical cancer tissues and corresponding adjacent tissues down-regulated expression LncRNA CRNDE could promote the cell growth and stimulate the metastasis of cervical cancer cells. 29194035
gastric cancer qRT-PCR, knockdown, western blot, gastric cancer specimens, gastric cancer cell lines, normal gastric tissue, normal gastric cell lines up-regulated expression CRNDE exerted its oncogenic role by affecting PI3K/AKT signaling pathways. 29243780
osteosarcoma osteosarcoma tissues and cell lines up-regulated expression LncRNA, CRNDE promotes osteosarcoma cell proliferation, invasion and migration by regulating Notch1 signaling and epithelial-mesenchymal transition 29246789
papillary thyroid carcinoma western blot, Overexpression, qRT-PCR papillary thyroid cancer（PTC ）cell and tissues up-regulated expression PTN was predicted as a downstream target of miR-384, which was confirmed by luciferase reporter assay, and PTN was up-regulated in PTC tissues, and was negatively correlated with miR-384 expression and positively correlated with CRNDE expression in PTC tissues. 29299168
acute myeloid leukemia acute myeloid leukemia cell line U937 differential expression expression LncRNA-CRNDE is highly expressed in the bone marrow tissues of AML patients, and the expression level is negatively correlated with the total survival of those clinical patients. 29461608
intrahepatic cholangiocarcinoma IHCC cell lines and tissues up-regulated expression CRNDE may be a novel prognostic marker and therapeutic target in IHCC. 29556285
hematologic cancer overexpression 2938 patient samples from 15 solid and hematopoietic tumors up-regulated expression Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers. 29808251
solid tumor overexpression 2938 patient samples from 15 solid and hematopoietic tumors up-regulated expression Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers. 29808251
hepatocellular carcinoma loss- and gain-functions assays HCC malignant tissues up-regulated expression Long non-coding RNA CRNDE promotes heptaocellular carcinoma cell proliferation by regulating PI3K/Akt /β-catenin signaling. 29864897
LPS-induced inflammation injury knockdown, western blot, ELISA, overexpression, WI-38 cells up-regulated expression CRNDE overexpression accelerated LPS-induced apoptosis and inflammation via up-regulation of FOXM1 in WI-38 cells. 29864958
clear cell renal cell carcinoma loss- and gain-of-function, overexpression clear cell renal cell carcinoma tissue specimens and cell lines up-regulated expression CRNDE overexpression is associated with clinical progression, and served as an independent prognostic marker for patients with ccRCC. CRNDE- enhanced ccRCC cell migration and invasion through modulating EMT-associated genes 30129055
tongue squamous cell carcinoma Overexpression TSCC samples and paired adjacent nontumor samples up-regulated expression CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR-384. 30242873
hepatocellular carcinoma qRT-PCR, luciferase reporter assay, western blot, microarray HCC tissues and HCC cell lines up-regulated expression Long non-coding RNA CRNDE promotes the proliferation, migration and invasion of hepatocellular carcinoma cells through miR-217/MAPK1 axis. 30246921
postmenopausal osteoporosis qRT-PCR, overexpression, knockdown, OH (osteoclast from healthy people) and OP (osteoclast from patients with postmenopausal osteoporosis) up-regulated expression Overexpressing CRNDE increased the viability in OH whilst reducing CRNDE in OP decreased the viability. 30280760
colorectal cancer Loss-of-function assays, knockdown, western blot clinical tissues and cell lines of cervical cancer. up-regulated expression CRNDE is markedly up-regulated in clinical tissues and cell lines of cervical cancer. 30334449
hepatocellular carcinoma qRT-PCR, overexpression, western blot, RNA immunoprecipitation, luciferase assays, HCC cells up-regulated expression Colorectal Neoplasia Differentially Expressed Gene as a Potential Target to Upregulate the Expression of IRX5 by miR-136-5P to Promote Oncogenic Properties in Hepatocellular Carcinoma 30423553
hepatocellular carcinoma knockdown tumor tissues compared with adjacent normal tissues up-regulated expression CRNDE could modulate EMT of HCC cells and knockdown of CRNDE impaired the mesenchymal properties. 30430650
head and neck squamous cell carcinoma western blot, overexpression, clinical tissues and cell lines of cervical cancer up-regulated expression LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cellproliferation and tumorigenesis by promoting cell-cycle progression. 30476843
diabetic cardiomyopathy overexpression cardiac fibroblasts (CFs), mice with DCM up-regulated expression Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy. 30748104
oral squamous cell carcinoma ISH, qRT-PCR, immunofluorescence staining,western blot, immunohistochemical assay, knockdown OSCC tissues and cell lines up-regulated expression Silencing CRNDE may inhibit EMT, thus decreasing the migration and invasion of human OSCC cells by repressing the activation of the Wnt/β-catenin signaling pathway, thereby restricting cell growth and promoting cell apoptosis. 30867767
cervical cancer overexpression, knockdown, loss- and gain-of-function approaches cervical cancer tissues and several cervical cancer cell lines up-regulated expression Long non-coding RNA CRNDE enhances cervical cancer progression by suppressing PUMA expression. 31202167
traumatic brain injury knockdown serum, rat model up-regulated expression Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats. 31345079
osteosarcoma qRT-PCR, western blot OS tissues and cell lines up-regulated expression CRNDE promoted glycogen synthase kinase-3β phosphorylation to activate the Wnt/β-catenin pathway. 31898343
Synchronous colorectal liver metastasis qRT-PCR, western blot serum of SCLM patients up-regulated expression lncRNA CRNDE and lncRNA SNHG7 could be promising biomarkers for prediction of OS and tumor recurrence in SCLM underwent hepatectomy. 32210611
sepsis-induced acute kidney injury lipopolysaccharides overexpression HK-2 cells up-regulated expression CRNDE overexpression could activate the TLR4/NF-κB signaling pathway by regulating miR-146a, which accelerated LPS-induced inflammation and apoptosis in HK-2 cells. 32399391


Function (not disease relevant)
Drug/chemo/stress Methods Sample/condition Expression pattern Dysfunction type Description PMID
immunohistochemical, western blot, immunoprecipitation experiments, knockdown, overexpression, HeLa cells expression By using bioinformatics methods, we identified the 84-amino acid ORF encoded by one of two CRNDEtranscripts, previously described by our research team. This ORF was cloned into two expression vectors, subsequently utilized in localization studies in HeLa cells. We also developed a polyclonal antibody against CRNDEP. Its specificity was confirmed in immunohistochemical, cellular localization, western blot and immunoprecipitation experiments, as well as by showing a statistically significant decrease of endogenous CRNDEP expression in the cells with transient shRNA mediated knockdown of CRNDE. 25978564
microarray, overexpression, knockdown astrocytes, glioma U87MG cell line expression CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll-like receptor pathway. 28621230
expression CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. 29405523


Interaction
Interaction target Level of interaction Type of interaction Methods Description PMID
Bcl-3 RNA-Protein regulation N/A the overexpression of CRNDE promoted VSMCs proliferation and repressed cell apoptosis in AAA by up-regulating Smad3 via Bcl-3. 32240036
C-IAP1 RNA-Protein binding N/A RNA-Pulldown and RIP assay authenticated CRNDE can specified binding with DMBT1 and c-IAP1. 27637083
DMBT1 RNA-Protein binding N/A RNA-Pulldown and RIP assay authenticated CRNDE can specified binding with DMBT1 and c-IAP1. 27637083
EZH2 RNA-Protein binding N/A LncRNA CRNDE could epigenetically suppress the expressions of dual-specificity phosphatase 5 (DUSP5) and CDKN1A by binding to EZH2 (the key components of Polycomb repressive complex 2 (PRC2)), thus promoting CRC development. 28796262
hnRNPUL2 RNA-Protein regulation N/A CRNDE could form a functional complex with heterogeneous nuclear ribonucleoprotein U-like 2 protein (hnRNPUL2) and direct the transport of hnRNPUL2 between the nucleus and cytoplasm. hnRNPUL2 that was accumulated in the cytoplasm could interact with CRNDE both physically and functionally, increasing the stability of CRNDE RNA. 28594403
miR-101 RNA-RNA binding western blot CRNDE was a decoy of mir-101 and its effect on Pca progression was reversed by mir-101. 32182086
miR-126-5p RNA-RNA regulation western blot, RIP CRNDE could specifically bind to miR-126-5p and reduce its expression. 32031750
miR-1277 RNA-RNA regulation western blot we also found that miR-1277 was negatively regulated by CRNDE and was a direct target of CRNDE. 31632559
miR-136 RNA-RNA binding N/A CRNDE functioned as a competing endogenous RNA for miR-136, led to the de-repression of its endogenous target, E2F transcription factor 1 (E2F1) 28115855
miR-136-5p RNA-RNA regulation N/A Based on predicted CRNDE/miR-136-5p/mRNA interactions, both the mRNA and protein expression analyses suggested that miR-136-5p-mediated repression of Bcl-2 and Wnt2 underlies the pro-tumoral actions of CRNDE. 29152149
miR-141 RNA-RNA binding luciferase reporter assay, RIP Moreover, miR-141 expression was low in LPS-induced MRC-5 cells and was verified was a target miRNA of CRNDE by using luciferase reporter assay and RIP assay. 32317619
miR-145 RNA-RNA regulation western blot MiR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. 28490034
miR-181a-5p RNA-RNA regulation western blot CRNDE binds to miR-181a-5p and represses its expression. The lncRNA CRNDE could regulate the progression and chemoresistance of CRC via modulating the expression levels of miR-181a-5p and the activity of Wnt/β-catenin signaling. 28086904
miR-183 RNA-RNA binding western blot, luciferase reporter assay miR-183 mimic could inverse the anti-tumor function of CRNDE inhibition and partially eliminated the attenuated expression of CCNB1 induced by silencing CRNDE, indicating that CRNDE could positively regulate CCNB1 expression by sponging miR-183. 31605132
miR-203 RNA-RNA binding western blot LncRNA CRNDE could enhance HCC tumorgenesis by sponging miR-203 and mediating BCAT1. 30230527
miR-203 RNA-RNA binding western blot VEGFA is a direct target of miR-203. 32182608
miR-205 RNA-RNA binding N/A LncRNA CRNDE promotes the migration and invasion of melanoma by sponging miR-205 and releasing CCL18. 30257602
miR-217 RNA-RNA binding western blot CRNDE involves in the cell proliferation, migration and invasion of colorectal cancer cells via increasing the expression of TCF7L2 and activity of Wnt/β-catenin signaling through binding miR-217 competitively. 28472810
miR-29c-3p RNA-RNA binding RIP CRNDE was found to be act as miR-29c-3p sponge. 31753063
miR-337-3p RNA-RNA binding western blot lncRNA CRNDE served as an oncogene, partly through sponging miR-337-3p and upregulating SIX1 in HCC. 31099050
miR-338-3p RNA-RNA binding N/A MiR-338-3p is a downstream target of CRNDE and that miR-338-3p inhibition partially reversed the CRNDE depletion-mediated inhibitory effect on cell proliferation, colony formation, migration and invasion in NSCLC cells. 30554121
miR-33a RNA-RNA binding N/A the binding relationship between CRNDE and miR-33a and the targeting relationship between miR-33a and HMGA2 were verified. 31416393
miR-424 RNA-RNA regulation N/A Luciferase reporter gene assay indicated that CRNDE could be targeted by microRNA-424 through specific a binding site, further regulating the malignant progression of Wilms' tumor. 32096178
miR-495 RNA-RNA regulation RIP, luciferase reporter assay The interaction between CRNDE and miR-495 was confirmed by RNA immunoprecipitation and RNA pull-down assay. CRNDE promoted DSS-induced colonic epithelial cell apoptosis via suppressing miR-495 and increasing SOCS1 31251902
miR-495 RNA-RNA binding RIP, luciferase reporter assay The interaction between CRNDE and miR-495 was confirmed by RNA immunoprecipitation and RNA pull-down assay. 31251902
miR-539-5p RNA-RNA binding western blot, RNA pulldown lncRNA CRNDE adsorbed miR-539-5p acts as a competitive endogenous RNA to regulate POU2F1 expression indirectly. 32252678
miR-641 RNA-RNA binding luciferase reporter assay, western blot CRNDE level was upregulated in NSCLC, and its knockdown suppressed NSCLC cells proliferation and enhanced apoptosis, whereas miR-641 antagonized the regulatory effect of CRNDE knockdown by directly binding to CRNDE. Moreover, CDK6 was a target of miR-641 and miR-641 exerted anti-proliferation and pro-apoptosis effects through CDK6. 30982057
PRC2 RNA-DNA regulation N/A the mechanistic investigations showed that CRNDE could interact with PRC2 and recruit its core component EZH2 to p21 (CDKN1A) promoter regions and repress its transcription. 28550688
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