mucosal immunity |
|
Immunoblotting, Immunoprecipitation, Knockdown, overexpresion, RNA-seq, Rescue Experiments, qRT-PCR |
BMDMs cell, RiboTag (B6N.129 strain) and LysM-Cre (B6.129P2 strain) mice |
up-regulated |
expression |
We show that the translation of a new ORF hidden within the long non-coding RNA Aw112010 is essential for the orchestration of mucosal immunity during both bacterial infection and colitis. |
30542152 |
age-related hearing loss |
resveratrol and STR1720 |
knockdown,overexpression,RNA-seq,qRT-PCR,western blot,immunocytochemistry |
early-onset AHL mouse model, HEI-OC1 cells and the mouse cochlea. |
up-regulated |
expression |
The Arid5b/AW112010 signaling was induced in the aged mouse cochlea and positively modulated the mitochondrial biogenesis to maintain mitochondrial function. |
31781342 |