| Disease |
| Disease |
Drug/chemo/stress |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
| uric acid nephropathy |
|
qRT-PCR, western blot, ELISA, luciferase reporter, rescue experiment, knockdown |
UAN patients and uric acid-treated HK-2 cells |
up-regulated |
interaction |
Knockdown of ANRIL alleviated renal injury of UAN rats. ANRIL exerted pathogenic effect in UAN to promote NLRP3 inflammasome activation via miR-122-5p/BRCC3 axis. |
30347231 |
| angiogenesis and thrombosis |
|
qRT-PCR, western blot, Luciferase reporter assays,ELISA,rescue assays,knockdown |
HUVECs, the cerebrum of mice and N2a cells exposed to I/R. |
up-regulated |
interaction |
ANRIL promotes angiogenesis and thrombosis by upregulating the expression of miR-99a and miR-449a during autophagy. |
31934291 |
| uric acid nephropathy |
|
qRT-PCR, ELISA, |
Rat models of UAN , UAN rats |
up-regulated |
expression |
Long non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats. |
30675335 |
| diabetes mellitus |
myocardial oxidative stress |
knockdown |
The rat model of diabetes, myocardial tissue of diabetic rats. |
up-regulated |
expression |
Interfering with long chain noncoding RNA ANRIL expression reduces heart failure in rats with diabetes by inhibiting myocardial oxidative stress. |
31211466 |
| cerebral infarction |
|
knockdown, western blot, qRT-PCR |
60 adult male Wistar rats |
up-regulated |
expression |
The inhibitory effect of lncRNA ANRIL knockdown on neuronal apoptosis in CI rats may be probably related to its inhibition of the NF-κB signaling pathway. |
31799680 |