LncRNA Information
ID	EL0149	Name	AGO2	Aliases	CASC7, EIF2C2, LINC00980, PPD, Q10
Species	Homo sapiens	Chromosome	8	Start site	140520156
End site	140642406	Chain	minus	Exon NO.	22
Assembly	GRCh38.p13	Class	lncRNA	NCBI accession	N/A
Ensembl	ENSG00000123908	Sequence	N/A	Peptide-related	N/A
CircRNA	yes	Exosomal	N/A	Structure	N/A

Disease
Disease	Drug/chemo/stress	Method	Sample	Expression pattern	Dysfunction type	Description	PMID
colorectal cancer		qRT-PCR, western blot, RIP, RNA pull-down, luciferase reporter assay,	CRC tissues and CRC cell lines	down-regulated	interaction	CASC7 overexpression could inhibit cell viability, migration and invasion, and promote apoptosis in CRC cells.	28954383
asthma		luciferase reporter assay, qRT-PCR, mimics, ELISA, western blot, Overexpression	Airway smooth muscle cells (ASMCs)	down-regulated	interaction	LncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3K/AKT signaling pathway by targeting miR-21 in severe asthma.	31412983
glioma		qRT-PCR, gain or loss-of function, luciferase activity, rescue assays	two glioma patients	down-regulated	expression	LncRNA CASC7 inhibits the progression of glioma via regulating Wnt/β-catenin signaling pathway.	30661904
neuroblastoma		overexpression,	neuroblastoma tissues compared to non-cancer tissues of neuroblastoma patients	down-regulated	expression	LncRNA cancer susceptibility candidate (CASC7) upregulates phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation.	32101951

Interaction
Interaction target	Level of interaction	Type of interaction	Methods	Description	PMID
miR-21	RNA-RNA	regulation	western blot, RIP	CASC7 inhibited colon cancer cell proliferation and migration via miR-21/ING3 axis.	28954383
miR-21	RNA-RNA	binding	luciferase reporter assay, ELISA, western blot	Overexpression of CASC7 suppressed the PI3K/AKT signaling pathway and promoted the inhibition effects of dexamethasone on cell proliferation and cytokines secretion via targeting miR-21.	31412983

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