LncRNA
ID Name Alias Species NCBI accession Ensembl
EL0001 116HG N/A Homo sapiensN/AN/A
EL0002 1700007L15Rik linc-Iqcg; linc1609 Mus musculusNR_045709ENSMUSG00000097318
EL0003 1B FGF-antisense transcripts N/A Homo sapiensN/AN/A
EL0004 4930503E24Rik 4930503E24Rik; NR_028310.1 Mus musculusNR_028310N/A
EL0005 4930570G19Rik C630015G22 Mus musculusNR_040399, NR_040398, NR_040400ENSMUSG00000085084
EL0006 51A antisense to intron 1 of the SORL1 gene Homo sapiensN/AN/A
EL0007 5430416N02Rik 100041797; Adapt33; Gm3514 Mus musculusNR_034038ENSMUSG00000097772
EL0008 5730458M16Rik N/A Mus musculusAK017674N/A
EL0009 6430411K18Rik PEG11as Mus musculusNR_002848N/A
EL0010 9130001E16Rik N/A Mus musculusXR_386048N/A
EL0011 9530018H14Rik lncRNA-HIT Mus musculusAK020562N/A
EL0012 A130040M12Rik CA782090; H3053C11; VL30 Mus musculusN/AN/A
EL0013 AA174084 N/A Homo sapiensN/AN/A
EL0014 AATBC N/A Homo sapiensNR_026961ENSG00000215458
EL0015 AB019562 N/A Homo sapiensN/AN/A
EL0016 AB073614 N/A Homo sapiensN/AN/A
EL0017 AB074278 N/A Homo sapiensN/AN/A
EL0018 AB209630 N/A Homo sapiensN/AN/A
EL0019 ABHD11-AS1 LINC00035; NCRNA00035; WBSCR26 Homo sapiensNR_026690ENSG00000225969
EL0020 Abhd11os 2010001M06Rik; AI462243; Wbscr26; Wnscr26 Mus musculusNR_026688ENSMUSG00000085042
EL0021 Abhd11os Wbscr26 Rattus norvegicusNR_026689N/A
EL0022 STAG3L2 AC004166.7; STAG3L2; MGC131759; STAG3L2P Homo sapiensNR_040584ENSG00000277072
EL0023 AC006050.3-003 N/A Homo sapiensN/AN/A
EL0024 LOC101927596 AC013264.2 Homo sapiensNR_135584ENSG00000231621
EL0025 MTCO1P5 MTCO1P5; AC026166.2-001 Homo sapiensN/AENSG00000233026
EL0026 AC058791.1 LOC646329 Homo sapiensNR_034120ENSG00000226380
EL0027 PLAC9P1 AC079776.2 Homo sapiensNR_026740ENSG00000214100
EL0028 AC100865.1 N/A Homo sapiensN/AN/A
EL0029 AC104699.1 N/A Homo sapiensN/AENSG00000224220
EL0030 AC104699.1.1 N/A Homo sapiensN/AN/A
EL0031 ACTA2-AS1 ZXF1; uc001kfo.1 Homo sapiensNR_125373ENSG00000180139
EL0032 ADAMTS9-AS2 N/A Homo sapiensNR_038264ENSG00000241684
EL0033 Adapt15 Gadd7 Cricetulus griseusNR_045124N/A
EL0034 AF070632 N/A Homo sapiensN/AN/A
EL0035 AF075041 N/A Homo sapiensN/AN/A
EL0036 AF086415 N/A Homo sapiensN/AN/A
EL0037 AF116616 ASLNC13387; AF116616 Homo sapiensN/AN/A
EL0038 AF118081 N/A Homo sapiensN/AN/A
EL0039 AF339813 N/A Homo sapiensN/AN/A
EL0040 AFAP1-AS1 AFAP1-AS; AFAP1AS Homo sapiensNR_026892ENSG00000272620
EL0041 AGAP2-AS1 PUNISHER Homo sapiensNR_027032ENSG00000255737
EL0042 AI364715 N/A Homo sapiensN/AN/A
EL0043 AIRN AIR; IGF2R-AS; IGF2R-AS1; IGF2RAS; NCRNA00088 Homo sapiensNR_047511, NR_047514ENSG00000268257
EL0044 Airn 2810051F02Rik; 2810434M15Rik; AI256653; AI597500; AW049873; Air; B930018I07Rik; D17Ertd663e; IGF2RAS Mus musculusNR_027773, NR_027772, NR_027784, NR_002853ENSMUSG00000078247
EL0045 AK022029 N/A Homo sapiensN/AN/A
EL0046 AK022159 N/A Homo sapiensN/AN/A
EL0047 AK028007 N/A Mus musculusN/AN/A
EL0048 AK038798 N/A Mus musculusN/AN/A
EL0049 AK042766 N/A Mus musculusN/AN/A
EL0050 AK044955 N/A Mus musculusN/AN/A
EL0051 AK056988 N/A Homo sapiensN/AN/A
EL0052 AK057054 N/A Homo sapiensN/AN/A
EL0053 AK081227 N/A Mus musculusN/AN/A
EL0054 AK093543 N/A Homo sapiensN/AN/A
EL0055 AK094838 ASLNC18814; AK094838 Homo sapiensN/AN/A
EL0056 AK095147 N/A Homo sapiensN/AN/A
EL0057 AK123657 N/A Homo sapiensN/AN/A
EL0058 AK123790 N/A Homo sapiensN/AN/A
EL0059 AK130977 N/A Homo sapiensN/AN/A
EL0060 AK133540 N/A Mus musculusN/AN/A
EL0061 AK133808 N/A Mus musculusN/AN/A
EL0062 AK139328 N/A Mus musculusN/AN/A
EL0063 AK143294 N/A Mus musculusN/AN/A
EL0064 AK143693 N/A Mus musculusN/AN/A
EL0065 AK153778 N/A Mus musculusN/AN/A
EL0066 AKR7L AFAR3; AFB1-AR3; AKR7A4 Homo sapiensNR_040289, NR_040288ENSG00000211454
EL0067 AL389956 N/A Homo sapiensN/AN/A
EL0068 Alg2 1110018A23Rik; 1300013N08Rik; ALPG2; CDGIi; MNCb-5081 Mus musculusAK209601.1ENSMUSG00000039740
EL0069 alncRNA-EC7 N/A Mus musculusN/AN/A
EL0070 alpha-250 and alpha-280 N/A Homo sapiensN/AN/A
EL0071 alpha-280/250 N/A Homo sapiensN/AN/A
EL0072 alpha-MHC antisense transcripts N/A Mus musculusN/AN/A
EL0073 Alu lncRNAs N/A Homo sapiensN/AN/A
EL0074 Ancr-1 N/A Apis melliferaNR_003566N/A
EL0075 antisense TGF beta 3 N/A Gallus gallusN/AN/A
EL0076 AOC4P AOC4; UPAT Homo sapiensNR_002773ENSG00000260105
EL0077 AP000688.29 N/A Homo sapiensN/AN/A
EL0078 AP001439.1 AP001439.2 Homo sapiensN/AENSG00000224541
EL0079 AP5M1 C14orf108; MUDENG; Mu5; MuD Homo sapiensNR_026895ENSG00000053770
EL0080 APOA1-AS N/A Homo sapiensNR_126362ENSG00000235910
EL0081 APOLO N/A Arabidopsis thalianaN/AN/A
EL0082 APTR RSBN1L-AS1 Homo sapiensNR_134251, NR_134254, NR_134253, NR_038361ENSG00000214293
EL0083 ARA N/A Homo sapiensN/AN/A
EL0084 Arid2-IR N/A Homo sapiensN/AN/A
EL0085 AS Uchl1 N/A Mus musculusN/AN/A
EL0086 ASAR6 N/A Mus musculusN/AN/A
EL0087 ASAR6 N/A Homo sapiensN/AN/A
EL0088 ASCO-RNA N/A Arabidopsis thalianaN/AN/A
EL0089 asHSFB2a N/A Arabidopsis thalianaN/AN/A
EL0090 ASK00420 N/A Homo sapiensN/AN/A
EL0091 ASL N/A Arabidopsis thalianaN/AN/A
EL0092 ASLNC00339 ASLNC00339; uc.341- Homo sapiensN/AN/A
EL0093 ASncmtRNAs N/A Homo sapiensN/AN/A
EL0094 asOct4-pg5 N/A Homo sapiensN/AN/A
EL0095 AT102202 N/A Homo sapiensN/AN/A
EL0096 AT1G04425 AT1G04425 Arabidopsis thalianaNR_143387N/A
EL0097 AT1G10682 AT1G10682 Arabidopsis thalianaNR_139737N/A
EL0098 AT1G11175 AT1G11175 Arabidopsis thalianaNR_143555N/A
EL0099 AT1G11185 AT1G11185 Arabidopsis thalianaNR_143556N/A
EL0100 AT1G13448 AT1G13448 Arabidopsis thalianaNR_139742N/A
EL0101 AT1G15002 AT1G15002 Arabidopsis thalianaN/AN/A
EL0102 AT1G15175 AT1G15175 Arabidopsis thalianaNR_139747, NR_139745, NR_139746N/A
EL0103 AT1G15405 AT1G15405 Arabidopsis thalianaNR_143560N/A
EL0104 AT1G16635 AT1G16635 Arabidopsis thalianaNR_143561N/A
EL0105 AT1G18745 AT1G18745 Arabidopsis thalianaNR_143562N/A
EL0106 AT1G21529 AT1G21529 Arabidopsis thalianaNR_143564N/A
EL0107 AT1G26208 AT1G26208 Arabidopsis thalianaNR_139783, NR_139785, NR_139784, NR_139787, NR_139786, NR_139788N/A
EL0108 AT1G26558 AT1G26558 Arabidopsis thalianaNR_143570, NR_143571N/A
EL0109 AT1G31935 AT1G31935 Arabidopsis thalianaNR_143573N/A
EL0110 AT1G34418 AT1G34418 Arabidopsis thalianaNR_143576N/A
EL0111 AT1G43765 AT1G43765 Arabidopsis thalianaNR_143577N/A
EL0112 AT1G46554 AT1G46554 Arabidopsis thalianaNR_143578N/A
EL0113 AT1G57835 AT1G57835 Arabidopsis thalianaNR_143584N/A
EL0114 AT1G58590 AT1G58590 Arabidopsis thalianaNR_143585, NR_143586N/A
EL0115 AT1G64618 AT1G64618 Arabidopsis thalianaNR_143590N/A
EL0116 AT1G67105 AT1G67105 Arabidopsis thalianaNR_143592N/A
EL0117 AT1G67365 AT1G67365 Arabidopsis thalianaNR_139904N/A
EL0118 AT1G69252 AT1G69252 Arabidopsis thalianaNR_143594, NR_143595N/A
EL0119 AT1G70518 AT1G70518 Arabidopsis thalianaNR_143597N/A
EL0120 AT1G74205 AT1G74205 Arabidopsis thalianaN/AN/A
EL0121 At1NC018710 N/A Arabidopsis thalianaKJ935038N/A
EL0122 AT1TU075330 N/A Arabidopsis thalianaN/AN/A
EL0123 AT1TU099900 N/A Arabidopsis thalianaN/AN/A
EL0124 AT2G01422 AT2G01422 Arabidopsis thalianaNR_143713, NR_143714N/A
EL0125 AT2G06002 AT2G06002 Arabidopsis thalianaNR_143731N/A
EL0126 AT2G09795 AT2G09795 Arabidopsis thalianaNR_140605, NR_140604, NR_140603N/A
EL0127 AT2G14878 AT2G14878 Arabidopsis thalianaNR_143748N/A
EL0128 AT2G15292 AT2G15292 Arabidopsis thalianaNR_143750N/A
EL0129 AT2G15555 AT2G15555 Arabidopsis thalianaNR_143751N/A
EL0130 AT2G18735 AT2G18735 Arabidopsis thalianaNR_143754N/A
EL0131 AT2G26355 AT2G26355 Arabidopsis thalianaNR_140673N/A
EL0132 AT2G31585 AT2G31585 Arabidopsis thalianaNR_143761, NR_143762N/A
EL0133 AT2G32315 AT2G32315 Arabidopsis thalianaNR_140697N/A
EL0134 AT2G32795 AT2G32795 Arabidopsis thalianaNR_143763N/A
EL0135 AT2G41178 AT2G41178 Arabidopsis thalianaNR_140743, NR_140744N/A
EL0136 AT2G41312 AT2G41312 Arabidopsis thalianaNR_143767, NR_143768N/A
EL0137 AT2G42388 AT2G42388 Arabidopsis thalianaNR_143769N/A
EL0138 AT2G42485 AT2G42485 Arabidopsis thalianaNR_143771N/A
EL0139 AT2G43375 AT2G43375 Arabidopsis thalianaNR_143772N/A
EL0140 AT2G44798 AT2G44798 Arabidopsis thalianaNR_140771, NR_140770, NR_140768, NR_140769, NR_140773, NR_140772, NR_140774, NR_140777, NR_140775, NN/A
EL0141 AT2G44995 AT2G44995 Arabidopsis thalianaNR_143773N/A
EL0142 AT2G45023 AT2G45023 Arabidopsis thalianaNR_143774, NR_143775N/A
EL0143 AT2G45245 AT2G45245 Arabidopsis thalianaNR_143779, NR_143777, NR_143778, NR_143776N/A
EL0144 AT2G46192 AT2G46192 Arabidopsis thalianaNR_143781N/A
EL0145 At2NC044550 N/A Arabidopsis thalianaN/AN/A
EL0146 AT2TU076050 N/A Arabidopsis thalianaN/AN/A
EL0147 AT2TU077810 N/A Arabidopsis thalianaN/AN/A
EL0148 AT3G04485 AT3G04485 Arabidopsis thalianaNR_143900N/A
EL0149 AT3G06125 AT3G06125 Arabidopsis thalianaNR_143908, NR_143909, NR_143910N/A
EL0150 AT3G07215 AT3G07215 Arabidopsis thalianaNR_143920, NR_143921, NR_143919, NR_143922N/A
EL0151 AT3G13277 AT3G13277 Arabidopsis thalianaNR_143938N/A
EL0152 AT3G27884 AT3G27884 Arabidopsis thalianaNR_141631, NR_141632, NR_141630N/A
EL0153 AT3G27990 AT3G27990 Arabidopsis thalianaNR_141633, NR_141634, NR_141635, NR_141636N/A
EL0154 AT3G29644 AT3G29644 Arabidopsis thalianaNR_141640, NR_141637, NR_141639, NR_141638, NR_141641N/A
EL0155 AT3G44798 AT3G44798 Arabidopsis thalianaNR_143947N/A
EL0156 AT3G45638 AT3G45638 Arabidopsis thalianaNR_143948, NR_143949N/A
EL0157 AT3G48115 AT3G48115 Arabidopsis thalianaNR_143950, NR_143951N/A
EL0158 AT3G52072 AT3G52072 Arabidopsis thalianaNR_141677, NR_141673, NR_141675, NR_141676, NR_141672, NR_141674, NR_141678N/A
EL0159 AT3G52742 AT3G52742 Arabidopsis thalianaNR_143952N/A
EL0160 AT3G52748 AT3G52748 Arabidopsis thalianaNR_143953N/A
EL0161 AT3G54366 AT3G54366 Arabidopsis thalianaNR_143955N/A
EL0162 AT3G57157 AT3G57157 Arabidopsis thalianaNR_143957N/A
EL0163 AT3G59765 AT3G59765 Arabidopsis thalianaNR_141706, NR_141705, NR_141704N/A
EL0164 AT3G60972 AT3G60972 Arabidopsis thalianaNR_143960N/A
EL0165 AT3G61198 AT3G61198 Arabidopsis thalianaNR_143962N/A
EL0166 AT3TU028510 N/A Arabidopsis thalianaN/AN/A
EL0167 AT3TU075200 N/A Arabidopsis thalianaN/AN/A
EL0168 At4 N/A Arabidopsis thalianaAF055372N/A
EL0169 At4-1 N/A Arabidopsis thalianaAY536062N/A
EL0170 At4-2 N/A Arabidopsis thalianaAY334555N/A
EL0171 At4-3 N/A Arabidopsis thalianaAI995459N/A
EL0172 AT4G01533 AT4G01533 Arabidopsis thalianaNR_143963N/A
EL0173 AT4G01593 AT4G01593 Arabidopsis thalianaNR_141720, NR_141721, NR_141722N/A
EL0174 AT4G02005 AT4G02005 Arabidopsis thalianaNR_141725, NR_141727, NR_141728, NR_141724, NR_141726, NR_141723N/A
EL0175 AT4G03811 AT4G03811 Arabidopsis thalianaNR_144062N/A
EL0176 AT4G06701 AT4G06701 Arabidopsis thalianaNR_144088, NR_144089, NR_144090, NR_144092, NR_144091N/A
EL0177 AT4G08035 AT4G08035 Arabidopsis thalianaNR_144096, NR_144097N/A
EL0178 AT4G13495 AT4G13495 Arabidopsis thalianaNR_144107, NR_144108N/A
EL0179 AT4G14548 AT4G14548 Arabidopsis thalianaNR_144109N/A
EL0180 AT4G15242 AT4G15242 Arabidopsis thalianaNR_144110N/A
EL0181 AT4G20362 N/A Arabidopsis thalianaN/AN/A
EL0182 AT4G30975 AT4G30975 Arabidopsis thalianaNR_142380, NR_142378, NR_142379N/A
EL0183 AT4G36648 AT4G36648 Arabidopsis thalianaNR_144117N/A
EL0184 AT4G38932 AT4G38932 Arabidopsis thalianaNR_142410N/A
EL0185 AT4G40065 AT4G40065 Arabidopsis thalianaNR_144119N/A
EL0186 At4NC047210 N/A Arabidopsis thalianaN/AN/A
EL0187 AT4TU030900 N/A Arabidopsis thalianaN/AN/A
EL0188 AT4TU034830 N/A Arabidopsis thalianaN/AN/A
EL0189 AT5G01175 AT5G01175 Arabidopsis thalianaNR_142485, NR_142484N/A
EL0190 AT5G03285 AT5G03285 Arabidopsis thalianaNR_144233N/A
EL0191 AT5G06165 AT5G06165 Arabidopsis thalianaNR_144254N/A
EL0192 AT5G07322 AT5G07322 Arabidopsis thalianaNR_144258N/A
EL0193 AT5G15022 AT5G15022 Arabidopsis thalianaNR_143266N/A
EL0194 AT5G23410 AT5G23410; K19M13.3; K19M13_3 Arabidopsis thalianaNR_144271N/A
EL0195 AT5G24735 AT5G24735 Arabidopsis thalianaNR_144274N/A
EL0196 AT5G40316 AT5G40316 Arabidopsis thalianaNR_144283N/A
EL0197 AT5G43403 AT5G43403 Arabidopsis thalianaNR_144284N/A
EL0198 AT5G43725 AT5G43725 Arabidopsis thalianaNR_144285, NR_144286N/A
EL0199 AT5G44569 AT5G44569 Arabidopsis thalianaNR_144287N/A
EL0200 AT5G48412 AT5G48412 Arabidopsis thalianaNR_144289N/A
EL0201 AT5G50190 AT5G50190; K6A12.5; K6A12_5 Arabidopsis thalianaNR_144291N/A
EL0202 At5NC025190 N/A Arabidopsis thalianaN/AN/A
EL0203 At5NC029980 N/A Arabidopsis thalianaN/AN/A
EL0204 At5NC055270 N/A Arabidopsis thalianaN/AN/A
EL0205 At5NC056820 N/A Arabidopsis thalianaN/AN/A
EL0206 AT5TU062110 N/A Arabidopsis thalianaN/AN/A
EL0207 AtCR20-1 N/A Arabidopsis thalianaD79218N/A
EL0208 AtGUT15 N/A Arabidopsis thalianaU84973N/A
EL0209 Atp2a2 9530097L16Rik; D5Wsu150e; SERCA2; SERCA2B; Serca2a; mKIAA4195 Mus musculusNR_027838ENSMUSG00000029467
EL0210 ATP6V1G2-DDX39B N/A Homo sapiensNR_037853ENSG00000254870
EL0211 AtR18 N/A Arabidopsis thalianaAB646771N/A
EL0212 AtR18 N/A Nicotiana tabacumN/AN/A
EL0213 AtR8 N/A Arabidopsis thalianaAB646770N/A
EL0214 AtR8 N/A Nicotiana tabacumN/AN/A
EL0215 ATXN7L3B lnc-SCA7 Homo sapiensN/AENSG00000253719
EL0216 ATXN8OS KLHL1AS; NCRNA00003; SCA8 Homo sapiensNR_002717N/A
EL0217 AX746718 N/A Homo sapiensN/AN/A
EL0218 AX800134 N/A Homo sapiensN/AN/A
EL0219 B1 SINE RNA N/A Meriones unguiculatusN/AN/A
EL0220 B1 SINE RNA N/A Mus musculusN/AN/A
EL0221 B130024G19Rik N/A Mus musculusNR_045850ENSMUSG00000100005
EL0222 B2 SINE RNA N/A Mus musculusN/AN/A
EL0223 B4GALT1-AS1 N/A Homo sapiensNR_108109, NR_108110, NR_108108ENSG00000233554
EL0224 BACE1-AS BACE1-AS1; BACE1AS; NCRNA00177 Homo sapiensNR_037803ENSG00000278768
EL0225 BALR-2 N/A Homo sapiensN/AN/A
EL0226 BALR-6 N/A Homo sapiensN/AN/A
EL0227 BANCR LINC00586 Homo sapiensNR_047671ENSG00000278910
EL0228 BC002350 ASLNC22124; BC002350 Homo sapiensN/AN/A
EL0229 BC011663 N/A Homo sapiensN/AN/A
EL0230 BC014579 N/A Homo sapiensN/AN/A
EL0231 BC017743 N/A Homo sapiensN/AN/A
EL0232 BC023629 N/A Homo sapiensN/AN/A
EL0233 BC091525 ASLNC23844; BC091525 Homo sapiensN/AN/A
EL0234 Bc1 Gm24367 Mus musculusNR_038088N/A
EL0235 BCAR4 N/A Homo sapiensNR_131216, NR_131222, NR_024050, NR_131217, NR_024049ENSG00000262117
EL0236 BcMF11 N/A Brassica campestrisDQ925484N/A
EL0237 BCYRN1 BC200; BC200a; LINC00004; NCRNA00004 Homo sapiensNR_001568ENSG00000236824
EL0238 BCYRN1P2 BC200g Homo sapiensN/AN/A
EL0239 BDNF-AS ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS Homo sapiensNR_033312, NR_033315, NR_033313, NR_002832, NR_033314ENSG00000245573
EL0240 BE503655 N/A Homo sapiensN/AN/A
EL0241 bft Dmel_CR42938; 263a; CR31863; CR33580; CR42938; DmelCR42938; Dmel_CR31863; Dmel_CR33580; dme-miR-263a; dme-mir-263a; miR-263; miR-263a; mir-263a Drosophila melanogasterN/AN/A
EL0242 BGLT3 BGL3; LINC01083; lncRNA-BGL3 Homo sapiensNR_121648ENSG00000260629
EL0243 BISPR lncBST2 Homo sapiensNR_130765, NR_130766ENSG00000282851
EL0244 BLACAT1 LINC00912; linc-UBC1; onco-lncRNA-30 Homo sapiensNR_103783ENSG00000281406
EL0245 BM742401 N/A Homo sapiensN/AN/A
EL0246 BOK-AS1 BOK-AS; BOKAS; NAToB; NCRNA00151 Homo sapiensNR_033346ENSG00000234235
EL0247 Borg N/A Mus musculusNR_131206N/A
EL0248 BPESC1 BPESC1; NCRNA00187 Homo sapiensNR_026783ENSG00000232416
EL0249 BRCA1 BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 Homo sapiensNR_027676ENSG00000012048
EL0250 Bvht Braveheart; Gm20748 Mus musculusNR_045420ENSMUSG00000098098
EL0251 BX647187 N/A Homo sapiensN/AN/A
EL0252 BX648207 N/A Homo sapiensN/AN/A
EL0253 bxd Dmel_CR31273; CR31273; CR31277; DmelCR31273 Drosophila melanogasterNR_002035, NR_002034, NR_002033, NR_002032N/A
EL0254 C1401f132 N/A Homo sapiensN/AN/A
EL0255 C14orf132 C14orf88 Homo sapiensN/AENSG00000227051
EL0256 C1orf74 URLC4 Homo sapiensN/AENSG00000162757
EL0257 PCOTH C1QTNF9B-AS1 Homo sapiensN/AENSG00000205861
EL0258 C2dat1 CAMK2D Mus musculusN/AN/A
EL0259 C530045E16Rik N/A Mus musculusAK049728N/A
EL0260 C5orf66-AS1 CTC-276P9.1; Epist Homo sapiensNR_105050, NR_105049ENSG00000249082
EL0261 C5T1lncRNA N/A Homo sapiensN/AN/A
EL0262 C730029A08Rik AK038898 Mus musculusAK050225N/A
EL0263 C730036E19Rik lncLSTR Mus musculusNR_038011ENSMUSG00000102095
EL0264 CACNAICAS3 N/A Homo sapiensN/AN/A
EL0265 CADM1 BL2; IGSF4; IGSF4A; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1 Homo sapiensN/AENSG00000182985
EL0266 CADM3-AS1 CTA-134P22.2; CADM3-AS1 Homo sapiensNR_037870ENSG00000225670
EL0267 CAHM LINC00468 Homo sapiensNR_037593ENSG00000270419
EL0268 CAI2 N/A Homo sapiensN/AN/A
EL0269 CAR Intergenic 10 N/A Homo sapiensN/AN/A
EL0270 CARs N/A Homo sapiensN/AN/A
EL0271 CASC15 LINC00340 Homo sapiensNR_015410ENSG00000272168
EL0272 CASC2 C10orf5 Homo sapiensNR_026939, NR_026940, NR_026941ENSG00000177640
EL0273 CASC9 ESCCAL-1; ESSCAL1; LINC00981 Homo sapiensNR_103849, NR_103850, NR_103848ENSG00000249395
EL0274 CBR3-AS1 PlncRNA-1; PlncRNA1 Homo sapiensNR_038893, NR_038892, NR_038894ENSG00000236830
EL0275 CCAL N/A Homo sapiensN/AN/A
EL0276 CCAT1 CARLo-5; onco-lncRNA-40 Homo sapiensNR_108049ENSG00000247844
EL0277 CCAT1-L N/A Homo sapiensN/AN/A
EL0278 CCAT2 LINC00873; NCCP1 Homo sapiensNR_109834ENSG00000280997
EL0279 CCAT3 N/A Homo sapiensN/AN/A
EL0280 CCAT7 N/A Homo sapiensN/AN/A
EL0281 CCAT8 N/A Homo sapiensN/AENST00000377549
EL0282 CCDC26 RAM Homo sapiensNR_130917, NR_130918, NR_130919, NR_130920ENSG00000229140
EL0283 CCEPR CCHE1; lncRNA-CCHE1 Homo sapiensNR_131782N/A
EL0284 CCLS96.1 N/A Silene latifoliaAB094078N/A
EL0285 CCND1 BCL1; D11S287E; PRAD1; U21B31 Homo sapiensN/AENSG00000110092
EL0286 CCND1 promoter-derived lncRNAs N/A Homo sapiensN/AN/A
EL0287 CD99P1 CD99L1; CXYorf12; MIC2R; NCRNA00103 Homo sapiensNR_033380, NR_033381ENSG00000223773
EL0288 Cdc28 lncRNA N/A Saccharomyces cerevisiaeN/AN/A
EL0289 CDKN2B-AS1 ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS Homo sapiensNR_003529, NR_047532, NR_047543, NR_047535, NR_047537, NR_047534, NR_047536, NR_047538, NR_120536, NENSG00000240498
EL0290 CDR1-AS CDR1NAT; CDR1as; ciRS-7 Homo sapiensAK094540N/A
EL0291 CECR3 N/A Homo sapiensNR_038398ENSG00000241832
EL0292 CECR9 N/A Homo sapiensN/AN/A
EL0293 ceruloplasmin NRCP Mus musculusN/AN/A
EL0294 CES1P1 CES1A2; CES1A3; CES4; CESR; PCE-3 Homo sapiensNR_003276ENSG00000228695
EL0295 CHL1-AS2 N/A Homo sapiensNR_144486, NR_144487ENSG00000224318
EL0296 CHRF N/A Homo sapiensN/AN/A
EL0297 cis-NATPHO1;2 N/A Oryza sativaAK071338N/A
EL0298 COL3A1 EDS4A Homo sapiensN/AENSG00000168542
EL0299 COLDAIR N/A Arabidopsis thalianaHG975388N/A
EL0300 COOLAIR N/A Arabidopsis thalianaGQ352646N/A
EL0301 CPS1-IT1 CPS1-IT; CPS1IT; CPS1IT1; PRO0132 Homo sapiensNR_002763ENSG00000280837
EL0302 CR613944 N/A Homo sapiensN/AN/A
EL0303 CR619813 CR619813; uc010meg.2 Homo sapiensN/AN/A
EL0304 CRG Dmel_CR44887; CR44887; DmelCR44887 Drosophila melanogasterNR_125225N/A
EL0305 CRNDE CRNDEP; LINC00180; NCRNA00180; PNAS-108; lincIRX5 Homo sapiensNR_034105, NR_110453, NR_110454, NR_034106ENSG00000245694
EL0306 Crxos AA606869; AY5908911; Egam1; Crxos Mus musculusNR_038092ENSMUSG00000074365
EL0307 AC130456.2 CTA-363E6.2 Homo sapiensN/AENSG00000259925
EL0308 CTB-167B5.2 N/A Homo sapiensN/AN/A
EL0309 AC021078.1 CTB-89H12.4 Homo sapiensN/AENSG00000230551
EL0310 CTBP1-AS PCAT10 Homo sapiensNR_104331ENSG00000280927
EL0311 CTD-3080P12.3 N/A Homo sapiensNR_109911ENSG00000249201
EL0312 CTD903 N/A Homo sapiensN/AN/A
EL0313 CU1NC165 N/A Cucumis sativusN/AN/A
EL0314 CU1NC272 N/A Cucumis sativusN/AN/A
EL0315 CU1NC333 N/A Cucumis sativusN/AN/A
EL0316 CU1NC355 N/A Cucumis sativusN/AN/A
EL0317 CU2NC636 N/A Cucumis sativusN/AN/A
EL0318 CU3NC1105 N/A Cucumis sativusN/AN/A
EL0319 CX3CL1 ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; fractalkine; neurotactin Homo sapiensN/AENSG00000006210
EL0320 CYP2C91 N/A Sus scrofaNR_132429N/A
EL0321 CYP4A22-AS1 ncRNA-a3 Homo sapiensN/AN/A
EL0322 Cyp4b1-ps2 Gm12839; OTTMUSG00000008630 Mus musculusNR_033575N/A
EL0323 CYP51A1-AS1 LRRD1-AS1 Homo sapiensNR_122109, NR_122110ENSG00000188693
EL0324 CYP707A1 N/A Arabidopsis thalianaAB428731N/A
EL0325 CYTOR C2orf59; LINC00152; NCRNA00152 Homo sapiensNR_024205, NR_024206, NR_024204ENSG00000222041
EL0326 Dab2 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Doc-2; Doc2; p96 Mus musculusN/AENSMUSG00000022150
EL0327 DACOR1 LP2570; TCONS_00023265 Homo sapiensN/AN/A
EL0328 Dalir Dali; Gm28525 Mus musculusNR_130904ENSMUSG00000099784
EL0329 DANCR AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR Homo sapiensNR_024031ENSG00000226950
EL0330 DAOA-AS1 DAOA-AS; DAOAAS; G30 Homo sapiensNR_040247ENSG00000232307
EL0331 DAPK1 DAPK Homo sapiensN/AENSG00000196730
EL0332 DBET DBE-T; DUX4L30 Homo sapiensNR_121644ENSG00000281591
EL0333 DBH-AS1 NCRNA00118 Homo sapiensNR_102735ENSG00000225756
EL0334 DDR2 MIG20a; NTRKR3; TKT; TYRO10 Homo sapiensN/AENSG00000162733
EL0335 DDX6P1 DDX6-Lp; DDX6P; bA150A6.3 Homo sapiensN/AENSG00000230056
EL0336 DGCR5 LINC00037; NCRNA00037 Homo sapiensNR_110533, NR_002733, NR_045121ENSG00000283406
EL0337 DHFR upstream transcripts DHFR minor transcript 5'-UTR; ENSG00000228716 Homo sapiensN/AN/A
EL0338 DHRS4-AS1 AS1DHRS4; C14orf167; DHRS4AS1; PRO1488 Homo sapiensNR_023922, NR_023923, NR_023924, NR_023921ENSG00000215256
EL0339 DIO3OS C14orf134; DIO3-AS1; DIO3-OS; NCRNA00041 Homo sapiensNR_002770N/A
EL0340 Dio3os AW556460; Dio3as Mus musculusNR_002866N/A
EL0341 DISC2 DISC1-AS1; DISC1OS; NCRNA00015 Homo sapiensNR_002227N/A
EL0342 DKFZP434K028 DKFZP434K028; LOC26070 Homo sapiensNR_026882ENSG00000124915
EL0343 DLEU1 BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 Homo sapiensNR_109974, NR_109973, NR_002605ENSG00000176124
EL0344 DLEU2 1B4; BCMSUN; DLB2; LEU2; LINC00022; MIR15AHG; NCRNA00022; RFP2OS; TRIM13OS Homo sapiensNR_002612ENSG00000231607
EL0345 Dleu2 1810047A16Rik; 4932411A06Rik; 7730401J12Rik; AI197277; AI788824; Alt1; Gm9069; Leu2 Mus musculusNR_028264ENSMUSG00000097589
EL0346 DLG2-AS1 DLG2-AS; DLG2AS; PSZA11q14; SZ-1 Homo sapiensN/AN/A
EL0347 Dlx1as Dix1as; Dlx1os Mus musculusNR_002854ENSMUSG00000084946
EL0348 Dlx4os A730090H04Rik; Dlx4as Mus musculusNR_040279ENSMUSG00000086552
EL0349 DLX6-AS1 DLX6-AS; DLX6AS; Evf-2; NCRNA00212 Homo sapiensNR_015448ENSG00000231764
EL0350 Dlx6os1 A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1; Evf1/2; Evf2; Shhrs; mEvf-1 Mus musculusNR_015388ENSMUSG00000090063
EL0351 DMRT2 N/A Homo sapiensN/AENSG00000173253
EL0352 Dmrt2 Terra Mus musculusN/AENSMUSG00000048138
EL0353 DMTF1 DMP1; DMTF; MRUL; hDMP1 Homo sapiensNR_024549, NR_024550ENSG00000135164
EL0354 DNM3OS DNM3-AS1; MIR199A2HG Homo sapiensNR_103486, NR_038397ENSG00000230630
EL0355 DQ786243 DQ786243 Homo sapiensN/AN/A
EL0356 DRAIC N/A Homo sapiensNR_026979ENSG00000245750
EL0357 Dreh N/A Mus musculusNR_105051N/A
EL0358 DSCAM-AS1 M41 Homo sapiensNR_038898, NR_038896, NR_038900, NR_038899ENSG00000235123
EL0359 dutA DDB_G0294515 Dictyostelium discoideum AX4N/AN/A
EL0360 E130102H24Rik N/A Mus musculusNR_040708ENSMUSG00000086782
EL0361 EBER N/A Epstein-Barr virusN/AN/A
EL0362 EEF1A1P9 EEF1AL7 Homo sapiensN/AN/A
EL0363 EFNA3 EFL2; EPLG3; Ehk1-L; LERK3 Homo sapiensN/AENSG00000143590
EL0364 EGFLAM-AS1 lncRNA-LOWEG; lncRNA-CTD-2108O9.1; EGFLAM-AS1 Homo sapiensN/AENSG00000249491
EL0365 EGFR-AS1 N/A Homo sapiensNR_047551ENSG00000224057
EL0366 EGOT EGO; NCRNA00190 Homo sapiensNR_004428ENSG00000235947
EL0367 EHHADH-AS1 N/A Homo sapiensNR_038990ENSG00000223358
EL0368 ELFN1-AS1 MYCLo-2 Homo sapiensNR_120510, NR_120509, NR_120508ENSG00000236081
EL0369 EMX2OS EMX2-AS1; NCRNA00045 Homo sapiensNR_002791ENSG00000229847
EL0370 Emx2os N/A Mus musculusNR_002863ENSMUSG00000087095
EL0371 ENO1 ENO1L1; HEL-S-17; MPB1; NNE; PPH Homo sapiensN/AENSG00000074800
EL0372 enod40 N/A Arabidopsis thalianaAK220907N/A
EL0373 enod40 N/A Brassica napusCX190651N/A
EL0374 enod40 N/A Daucus carotaBI452209N/A
EL0375 ENOD40 N/A Glycine sojaN/AN/A
EL0376 ENOD40 N/A Medicago truncatulaN/AN/A
EL0377 ENOD40 N/A Phaseolus vulgarisX86441N/A
EL0378 ENOD40 N/A Sesbania rostrataY12714N/A
EL0379 enod40 N/A Thlaspi caerulescensDN923678N/A
EL0380 ENOD40 N/A Vicia fabaN/AN/A
EL0381 ENOD40 N/A Vigna radiataAF061818N/A
EL0382 ENOD40 N/A Zea maysN/AN/A
EL0383 enod40 ENOD40; LjENOD40 Lotus japonicusN/AN/A
EL0384 enod40 Enod40; MsENOD40 Medicago sativaX80263N/A
EL0385 enod40 Ntenod40 Nicotiana tabacumX98716N/A
EL0386 enod40 OsENOD40 Oryza sativaAB024054N/A
EL0387 enod40 ENOD40; Mtenod40; MtENOD40 Medicago truncatulaX80264N/A
EL0388 ENOD40-1 GmENOD40 ENOD40 Glycine maxX69154N/A
EL0389 enod40-1 LjENOD40-1 Lotus japonicusAJ271787N/A
EL0390 enod40-2 LjENOD40-2 Lotus japonicusAJ271788N/A
EL0391 KCP CRIM21; NET67; KCP Homo sapiensN/AENSG00000135253
EL0392 TTTY7 CLONE795723; LINC00129; NCRNA00129A; TTTY7B; TTY7; TTTY7 Homo sapiensNR_001534ENSG00000147753
EL0393 AC079610.1 N/A Homo sapiensN/AENSG00000196096
EL0394 LINC00336 C6orf227; NCRNA00336 Homo sapiensNR_027908ENSG00000197251
EL0395 AL445248.1 N/A Homo sapiensN/AENSG00000203325
EL0396 AC006305.1 N/A Homo sapiensN/AENSG00000206129
EL0397 LINC01020 N/A Homo sapiensNR_026994ENSG00000215231
EL0398 FAM66B FAM66E Homo sapiensNR_027423ENSG00000215374
EL0399 LINC01139 LINK-A; LINKA Homo sapiensNR_015407ENSG00000215808
EL0400 LINC00323 C21orf130; NCRNA00323; PRED42 Homo sapiensNR_024100ENSG00000226496
EL0401 LINC01204 N/A Homo sapiensNR_104644, NR_104645ENSG00000229563
EL0402 LINC01721 N/A Homo sapiensNR_040102ENSG00000230133
EL0403 ENSG00000230544.1 N/A Homo sapiensN/AENSG00000230544
EL0404 ENSG00000231133.1 N/A Homo sapiensN/AENSG00000231133
EL0405 SPRY4-AS1 THCAT68 Homo sapiensNR_120664ENSG00000231185
EL0406 LEF1-AS1 LEF1NAT Homo sapiensNR_029374, NR_029373ENSG00000232021
EL0407 LINC01798 N/A Homo sapiensNR_110156ENSG00000232046
EL0408 ENSG00000232956.3 N/A Homo sapiensN/AENSG00000232956
EL0409 LINC01762 N/A Homo sapiensNR_125972, NR_125973ENSG00000233154
EL0410 LOC100129434 N/A Homo sapiensNR_125368ENSG00000233251
EL0411 SMIM2-IT1 C13orf44-IT1 Homo sapiensNR_046843ENSG00000235285
EL0412 ENSG00000237036.3 N/A Homo sapiensN/AENSG00000237036
EL0413 TTLL11-IT1 N/A Homo sapiensN/AENSG00000237548
EL0414 ENSG00000240453.1 N/A Homo sapiensN/AENSG00000240453
EL0415 AC093620.1 N/A Homo sapiensN/AENSG00000241269
EL0416 ENSG00000245910.3 N/A Homo sapiensN/AENSG00000245910
EL0417 AC109349.1 N/A Homo sapiensN/AENSG00000248176
EL0418 LOC101928858 N/A Homo sapiensNR_130779ENSG00000249364
EL0419 AC026427.1 N/A Homo sapiensN/AENSG00000249772
EL0420 LOC105377448 N/A Homo sapiensNR_133945ENSG00000250195
EL0421 LOC339874 N/A Homo sapiensNR_038976ENSG00000250608
EL0422 AL359075.2 N/A Homo sapiensN/AENSG00000254154
EL0423 AP001528.2 N/A Homo sapiensN/AENSG00000255471
EL0424 AC007848.2 N/A Homo sapiensN/AENSG00000256218
EL0425 LINC00929 N/A Homo sapiensNR_038852, NR_038851ENSG00000259150
EL0426 LINC00596 N/A Homo sapiensN/AENSG00000259334
EL0427 ENSG00000259484.1 N/A Homo sapiensN/AENSG00000259484
EL0428 ENSG00000259758.1 N/A Homo sapiensN/AENSG00000259758
EL0429 LINC00667 N/A Homo sapiensNR_015389ENSG00000263753
EL0430 AC016876.2 N/A Homo sapiensN/AENSG00000264772
EL0431 LINC01538 N/A Homo sapiensNR_033983ENSG00000266952
EL0432 Gm6768 N/A Mus musculusN/AENSMUSG00000021908
EL0433 ENSMUST00000041159 N/A Mus musculusN/AENSMUST00000041159
EL0434 Tdpx-ps1 N/A Mus musculusN/AENSMUSG00000082431
EL0435 Gm15054 N/A Mus musculusN/AENSMUSG00000084282
EL0436 Gm12919 N/A Mus musculusN/AENSMUSG00000083220
EL0437 Gm7327 N/A Mus musculusN/AENSMUSG00000050900
EL0438 Gm14155 N/A Mus musculusN/AENSMUSG00000087033
EL0439 Gm14089 N/A Mus musculusN/AENSMUSG00000084802
EL0440 ENSMUST00000142855 N/A Mus musculusN/AENSMUST00000142855
EL0441 Gm13133 N/A Mus musculusN/AENSMUSG00000086565
EL0442 Gm11827 N/A Mus musculusN/AENSMUSG00000086765
EL0443 Gm15834 N/A Mus musculusN/AENSMUSG00000085054
EL0444 ENSMUST00000167632 N/A Mus musculusN/AENSMUST00000167632
EL0445 ENST00000318333 ASHG19A3A043106; ENST00000318333; SRP9P1-201 Homo sapiensN/AENST00000318333
EL0446 RPL12P1 ASHG19A3A029791; ENST00000374520; RPL12P1-001 Homo sapiensN/AENSG00000204194
EL0447 ENST00000395084 N/A Homo sapiensN/AENST00000395084
EL0448 AL353608.3 ENST00000414223; RP11-561O23.5-002 Homo sapiensNR_015361ENSG00000234394
EL0449 ENST00000414355 N/A Homo sapiensN/AENST00000414355
EL0450 AL355581.1 RP11-73O6.3 Homo sapiensN/AENSG00000227678
EL0451 POM121L13P ASHG19A3A050006; ENST00000422362; POM121L13P-001 Homo sapiensN/AENSG00000236339
EL0452 LINC01384 LINC01384-001; ENST00000422494.1 Homo sapiensNR_109883ENSG00000237396
EL0453 LINC01852 RP11-1008C21.2-001; ENST00000434223 Homo sapiensN/AENSG00000236914
EL0454 ENST00000435885.1 N/A Homo sapiensN/AENST00000435885
EL0455 ENST00000442037 H19-015; ENST00000442037 Homo sapiensN/AENSG00000130600
EL0456 TDGF1P1 TDGF1P1-001; ENST00000445734 Homo sapiensN/AENSG00000227988
EL0457 ZNRD1ASP C6orf12; HCG8; HCGVIII; HCGVIII-1; HTEX4; NCRNA00171; TCTEX4; ZNRD1-AS; ZNRD1-AS1; ZNRD1AS; ZNRD1AS1 Homo sapiensNR_026751ENSG00000204623
EL0458 MTCO3P10 ASHG19A3A034382; ENST00000455912; RP11-1217F2.3-001 Homo sapiensN/AENSG00000231537
EL0459 AL133244.1 ASHG19A3A013479; ENST00000456007; AL133244.1-001 Homo sapiensN/AENSG00000223951
EL0460 AC096915.1 ASHG19A3A022744; ENST00000456185; RP11-24H1.1-001 Homo sapiensN/AENSG00000226082
EL0461 LINC00887 LINC00887-004; ENST00000456816 Homo sapiensN/AENSG00000214145
EL0462 ENST00000460164 RP11-731F5.2-002; ENST00000460164 Homo sapiensN/AENST00000460164
EL0463 AC004893.2 AC004893.11-002; ENST00000468960 Homo sapiensNR_110102ENSG00000242687
EL0464 ENST00000501583 N/A Homo sapiensN/AENST00000501583
EL0465 HAND2-AS1 DEIN; NBLA00301; UPH Homo sapiensNR_136197, NR_136196, NR_136195, NR_136201, NR_136194, NR_136199, NR_136200, NR_136192, NR_136193, NENSG00000237125
EL0466 AC012312.1 CTC-558O19.1-001; ENST00000503710 Homo sapiensN/AENSG00000249545
EL0467 LINC01096 LINC01096-002; ENST00000503938 Homo sapiensN/AENSG00000246095
EL0468 ENST00000537266 N/A Homo sapiensN/AENST00000537266
EL0469 AC022075.3 RP11-277P12.10-001; ENST00000539009 Homo sapiensN/AENSG00000256288
EL0470 AC026369.2 RP11-598F7.5-001; ENST00000540136 Homo sapiensN/AENSG00000256694
EL0471 LINC02446 RP11-291B21.2-001; ENST00000544591 Homo sapiensN/AENSG00000256039
EL0472 ENST00000545440 N/A Homo sapiensN/AENSG00000255717
EL0473 LINC01234 LCAL84; onco-lncRNA-32 Homo sapiensNR_110025, NR_110026ENSG00000249550
EL0474 LINC02086 CTD-2377D24.6-003; ENST00000575202 Homo sapiensN/AENSG00000244649
EL0475 EPB41L4A-AS1 C5orf26; NCRNA00219; TIGA1 Homo sapiensNR_015370N/A
EL0476 EPB41L4A-AS2 EPB41L4A Antisense RNA 2 Homo sapiensNR_027706ENSG00000278921
EL0477 EPOR EPO-R Homo sapiensNR_033663ENSG00000187266
EL0478 ERCC1 COFS4; RAD10; UV20 Homo sapiensXR_001753632, XR_001753631ENSG00000012061
EL0479 ERICD ERIC; LINC01130; TCONS_00014875 Homo sapiensN/AN/A
EL0480 DLGAP2 DAP2; SAPAP2; C8orf68; ERICH1-AS1 Homo sapiensNR_073397ENSG00000198010
EL0481 ESCCAL-5 N/A Homo sapiensN/AN/A
EL0482 ESRG HESRG Homo sapiensNR_027122ENSG00000265992
EL0483 EVADR N/A Homo sapiensNR_125857N/A
EL0484 EWSAT1 LINC00277; NCRNA00277; TMEM84 Homo sapiensNR_026949ENSG00000212766
EL0485 FADS1 D5D; FADS6; FADSD5; LLCDL1; TU12 Homo sapiensN/AENSG00000149485
EL0486 FALEC FAL1; LINC00568; ncRNA-a1 Homo sapiensNR_051960ENSG00000228126
EL0487 FAM30A C14orf110; HSPC053; KIAA0125 Homo sapiensNR_026800ENSG00000226777
EL0488 FAM3D-AS1 lnc-KCTD6-3 Homo sapiensNR_134853ENSG00000244383
EL0489 FAM83A-AS1 HCCC11; HCCC11_v1; HCCC11_v2 Homo sapiensNR_024479ENSG00000204949
EL0490 FAR2P1 HEL-182 Homo sapiensNR_026758ENSG00000180178
EL0491 FAS-AS1 FAS-AS; FASAS; SAF Homo sapiensNR_028371N/A
EL0492 FENDRR FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 Homo sapiensNR_033925, NR_036444ENSG00000268388
EL0493 Fendrr 1110050K14Rik; LL66; linc-Foxf1a; lincFoxf1 Mus musculusNR_045471, NR_130109ENSMUSG00000097336
EL0494 FER1L4 C20orf124 Homo sapiensNR_119376ENSG00000088340
EL0495 FEZF1-AS1 N/A Homo sapiensNR_036484ENSG00000230316
EL0496 FFAR2 FFA2R; GPR43 Homo sapiensAC002511.1ENSG00000126262
EL0497 FGF10-AS1 FGF10-AS1; RP11-473L15.2 Homo sapiensNR_108034ENSG00000248464
EL0498 FGF14-AS2 FGF14 antisense RNA 2 Homo sapiensNR_036487ENSG00000272143
EL0499 FGFR3-AS1 N/A Homo sapiensN/AN/A
EL0500 FH FMRD; HLRCC; LRCC; MCL; MCUL1 Homo sapiensN/AENSG00000091483
EL0501 Firre 5830467J12Rik; 6720401G13Rik; AW048145 Mus musculusNR_015505ENSMUSG00000085396
EL0502 FKBP10 BRKS1; FKBP65; OI11; OI6; PPIASE; hFKBP65 Homo sapiensN/AENSG00000141756
EL0503 FLC AT5G10140; AGAMOUS-like 25; AGL25; FLF; FLOWERING LOCUS C; FLOWERING LOCUS F; MADS BOX PROTEIN FLOWERING LOCUS F; REDUCED STEM BRANCHING 6; RSB6; T31P16.130; T31P16_130 Arabidopsis thalianaN/AN/A
EL0504 FMR1-AS1 ASFMR1; FMR1-AS; FMR1AS; FMR4 Homo sapiensNR_024503, NR_024502, NR_024501, NR_024499ENSG00000268066
EL0505 FMR5 N/A Homo sapiensN/AN/A
EL0506 FMR6 N/A Homo sapiensN/AN/A
EL0507 FOSB AP-1; G0S3; GOS3; GOSB Homo sapiensN/AENSG00000125740
EL0508 FOXC2-AS1 ODRUL Homo sapiensNR_125795ENSG00000260944
EL0509 FOXCUT LINC01379; TCONS_00011636 Homo sapiensNR_125804ENSG00000280916
EL0510 FR0257520 N/A Homo sapiensN/AN/A
EL0511 FR0348383 N/A Homo sapiensN/AN/A
EL0512 FRLnc1 N/A Homo sapiensN/AN/A
EL0513 frq antisense RNAs N/A Neurospora crassaN/AN/A
EL0514 FTX LINC00182; MIR374AHG; NCRNA00182 Homo sapiensNR_028379ENSG00000230590
EL0515 Ftx B230206F22Rik; BB219131; NCRNA00182; Thcytx Mus musculusNR_028381, NR_028380ENSMUSG00000086370
EL0516 G22 N/A LorisoideaN/AN/A
EL0517 G730013B05Rik linc-Cblb; linc1610 Mus musculusNR_040380, NR_040379ENSMUSG00000097694
EL0518 GACAT1 LINC00876 Homo sapiensNR_126370, NR_126369ENSG00000232991
EL0519 GACAT2 MTCL1-AS1; MTCL1AS1 Homo sapiensNR_120598ENSG00000265962
EL0520 GACAT3 LINC01458; lncRNA-AC130710 Homo sapiensNR_126559ENSG00000236289
EL0521 GADD45G CR6; DDIT2; GADD45gamma; GRP17 Homo sapiensN/AENSG00000130222
EL0522 GAL10 YBR019C Saccharomyces cerevisiae S288cN/AN/A
EL0523 GAPLINC LINC01540 Homo sapiensNR_110429, NR_110428ENSG00000266835
EL0524 GAS1RR LncRNA-Hh Homo sapiensNR_049794ENSG00000226237
EL0525 GAS2L3 G2L3 Homo sapiensN/AENSG00000139354
EL0526 GAS5 NCRNA00030; SNHG2 Homo sapiensNR_002578ENSG00000234741
EL0527 Gas5 Gas-5; Mir5117; Snhg2 Mus musculusNR_002840ENSMUSG00000053332
EL0528 GAS6-AS1 N/A Homo sapiensNR_044995ENSG00000233695
EL0529 GAS8-AS1 C16orf3 Homo sapiensNR_122031ENSG00000221819
EL0530 GATA3-AS1 N/A Homo sapiensNR_024256, NR_104328, NR_104330, NR_104329, NR_104327, NR_104336ENSG00000197308
EL0531 GDNF-AS1 GDNFOS Homo sapiensNR_103441ENSG00000248587
EL0532 Gfra1 AU042498 Mus musculusNR_104342ENSMUSG00000025089
EL0533 GHET1 lncRNA-GHET1 Homo sapiensNR_130107ENSG00000281189
EL0534 GHSR GHDP Homo sapiensN/AENSG00000121853
EL0535 Gli3 AI854843; AU023367; Bph; GLI3-190; GLI3FL; Pdn; Xt; add Mus musculusN/AENSMUSG00000021318
EL0536 Gm10371 ENSMUSG00000072589 Mus musculusNR_126579ENSMUSG00000072589
EL0537 Gm15050 OTTMUSG00000018865 Mus musculusXR_001785250ENSMUSG00000087626
EL0538 Gm15577 OTTMUSG00000024006 Mus musculusN/AENSMUSG00000086708
EL0539 Gm16845 N/A Mus musculusNR_040406, NR_040407ENSMUSG00000096981
EL0540 Gm2694 C230036H16Rik; linc1582 Mus musculusNR_033430, NR_125722ENSMUSG00000097248
EL0541 Gm30731 Pnky; lnc-pou3f2 Mus musculusNR_131335ENSMUSG00000107859
EL0542 Gm32592 N/A Mus musculusXR_377901ENSMUSG00000107902
EL0543 Gm6644 Akr1b3p; EG626009 Mus musculusNR_037965N/A
EL0544 GNAS-AS1 GNAS-AS; GNAS1AS; GNASAS; NCRNA00075; NESP-AS; NESPAS; SANG Homo sapiensNR_002785ENSG00000235590
EL0545 GNG12-AS1 N/A Homo sapiensNR_040077ENSG00000232284
EL0546 GRMZM2G010274_T01 N/A Zea maysN/AN/A
EL0547 GRMZM2G088590_T04 N/A Zea maysKJ682620N/A
EL0548 GRMZM2G420571_T01 N/A Zea maysKJ682541N/A
EL0549 GRMZM2G518002_T01 N/A Zea maysN/AN/A
EL0550 GRMZM2G580571_T01 N/A Zea maysN/AN/A
EL0551 AF181450.1 GS1-5L10.1 Homo sapiensN/AENSG00000253576
EL0552 GSTT1-AS1 N/A Homo sapiensNR_132348N/A
EL0553 GUCY1B2 GC-SB2 Homo sapiensNR_003923ENSG00000123201
EL0554 GUT15 AT2G18440; GENE WITH UNSTABLE TRANSCRIPT 15; T30D6.5; T30D6_5 Arabidopsis thalianaNR_143753, NR_143752N/A
EL0555 H19 AI747191 Mus musculusNR_130974, NR_130973ENSMUSG00000000031
EL0556 H19 ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 Homo sapiensNR_131224, NR_131223, NR_002196ENSG00000130600
EL0557 HA117 N/A Homo sapiensN/AN/A
EL0558 HAGLR HOXD-AS1; Mdgt Homo sapiensNR_033979, NR_110466, NR_110465, NR_110460, NR_110459, NR_110461, NR_110468, NR_110464, NR_110467, NENSG00000224189
EL0559 HAGLROS N/A Homo sapiensNR_110457N/A
EL0560 Halr1 Gm15055; Haunt; Linchoxa1; OTTMUSG00000018881; linc-Evx1; linc-Hoxa1; linc1547 Mus musculusNR_110440ENSMUSG00000085412
EL0561 HAR1A HAR1F; LINC00064; NCRNA00064 Homo sapiensNR_003244N/A
EL0562 HAR1B HAR1R; LINC00065; NCRNA00065 Homo sapiensNR_003245ENSG00000231133
EL0563 HBB CD113t-C; beta-globin Homo sapiensN/AENSG00000244734
EL0564 HCP5 6S2650E; D6S2650E; P5-1 Homo sapiensNR_040662ENSG00000206337
EL0565 HEIH HCCAT2; LINC-HEIH; LINC00848; lncRNA-HEIH Homo sapiensNR_045680ENSG00000278970
EL0566 HELLPAR LINC-HELLP; lncHELLP Homo sapiensJX088243.1 N/A
EL0567 HELLS ICF4; LSH; Nbla10143; PASG; SMARCA6 Homo sapiensXR_001747095ENSG00000119969
EL0568 HID1 N/A Arabidopsis thalianaKM044009N/A
EL0569 HIF1A-AS1 5'aHIF-1A; 5'aHIF1alpha Homo sapiensNR_047116ENSG00000258777
EL0570 HIF1A-AS2 3'aHIF-1A; aHIF Homo sapiensNR_045406ENSG00000258667
EL0571 HIF2PUT N/A Homo sapiensN/AN/A
EL0572 HIV1230 N/A Homo sapiensN/AN/A
EL0573 HLA-AS1 N/A Homo sapiensN/AN/A
EL0574 Hm629797 Mrhl Mus musculusHM629797ENSMUSG00000098439
EL0575 HNF1A-AS1 C12orf27; NCRNA00262 Homo sapiensNR_024345ENSG00000241388
EL0576 Hog Hotdog Mus musculus, Atelerix albiventrisBK008787N/A
EL0577 HOST2 N/A Homo sapiensN/AN/A
EL0578 HOTAIR HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 Homo sapiensNR_047517, NR_047518, NR_003716ENSG00000228630
EL0579 Hotair Gm16258; OTTMUSG00000032781 Mus musculusNR_047528ENSMUSG00000086903
EL0580 HOTAIRM1 HOXA-AS1; HOXA1-AS1; NCRNA00179 Homo sapiensNR_038366, NR_038367ENSG00000233429
EL0581 Hotairm1 Gm15051; Hoxaas1 Mus musculusNR_131181ENSMUSG00000087658
EL0582 HOTTIP HOXA-AS6; HOXA13-AS1; NCRNA00213 Homo sapiensNR_037843ENSG00000243766
EL0583 Hottip Gm15053 Mus musculusNR_110441, NR_110442ENSMUSG00000055408
EL0584 HOXA11-AS HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS Homo sapiensNR_002795ENSG00000240990
EL0585 Hoxa11os Hoxa11as; Hoxa11s Mus musculusNR_015348ENSMUSG00000086427
EL0586 HOXA13 HOX1; HOX1J Homo sapiensN/AENSG00000106031
EL0587 HOXA-AS CG7895; DmelCG7895; DmNK-4; DROHOXHK4; DROHOXNK4; HOX; msh-2; msh2; NK-4; NK-4/msh-2; NK4; NK4/msh-2; NKX2.5; Tin; TIN; tin/NK4 Homo sapiensN/AN/A
EL0588 HOXA-AS2 HOXA3as Homo sapiensNR_122069ENSG00000253552
EL0589 Hoxaas3 2700086A05Rik Mus musculusNR_015611ENSMUSG00000085696
EL0590 HOXA-AS3 HOXA6as Homo sapiensNR_038832, NR_038831ENSG00000254369
EL0591 Hoxd3as Dxoh-3; Hoxd3os Mus musculusN/AN/A
EL0592 HSR1 N/A Candida albicans SC5314N/AN/A
EL0593 Hsromega Dmel_CR31400; CR31400; DmelCR31400; HSRomega; Hsr-omega; Hsr93D-n; er3; hrsomega; hsr omega; hsr-omega; hsromega; hsrw; l(3)05241; l(3)93De; l(3)er3; n(3)05241; Hsromega Drosophila melanogasterNR_048444, NR_074035, NR_002068, NR_074036, NR_133429, NR_002067, NR_002069N/A
EL0594 HSUR1 Herpesvirus saimiri U RNAs Herpesvirus saimiriN/AN/A
EL0595 HSUR2 Herpesvirus saimiri U RNAs Herpesvirus saimiriN/AN/A
EL0596 HTT-AS HTT-AS1; HTTAS Homo sapiensNR_045414N/A
EL0597 HTTAS_v1 N/A Homo sapiensN/AN/A
EL0598 Huc1 H19 upstream conserved regions 1 & 2 Mus musculusN/AN/A
EL0599 Huc2 H19 upstream conserved regions 1 & 2 Mus musculusN/AN/A
EL0600 HULC HCCAT1; LINC00078; NCRNA00078 Homo sapiensNR_004855ENSG00000251164
EL0601 human immunodeficiency virus-encoded antisense RNAtranscript N/A Human Immunodeficiency VirusN/AN/A
EL0602 HvCesA6 N/A Hordeum vulgareN/AN/A
EL0603 HvISP1 N/A Hordeum vulgareAV911716N/A
EL0604 HYMAI NCRNA00020 Homo sapiensNR_002768ENSG00000283122
EL0605 ICR N/A Homo sapiensN/AN/A
EL0606 ICR1 ICR1 Saccharomyces cerevisiae S288cNR_132191N/A
EL0607 IFNG-AS1 GS1-410F4.2; NEST; Tmevpg1 Homo sapiensNR_104124, NR_104125ENSG00000255733
EL0608 IGF2-AS IGF2-AS1; IGF2AS; PEG8 Homo sapiensNR_028043, NR_133657ENSG00000099869
EL0609 IL7R CD127; CDW127; IL-7R-alphaA; ILRA; IL7R Homo sapiensNR_120485ENSG00000168685
EL0610 ILF3 CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b; NFAR; NFAR-1; NFAR2; TCP110; TCP80 Homo sapiensN/AENSG00000129351
EL0611 INTS7 C1orf73; INT7 Homo sapiensNR_037667ENSG00000143493
EL0612 IPO5P1 RP11-15H20.6 Homo sapiensNR_103742, NR_103741ENSG00000213971
EL0613 IPS1 AT3G09922; A. THALIANA INDUCED BY PHOSPHATE STARVATION1; ATIPS1; INDUCED BY PHOSPHATE STARVATION1 Arabidopsis thalianaAF236376N/A
EL0614 IPS1 N/A Brassica rapaJN575635N/A
EL0615 IPS1 N/A Nicotiana benthamianaN/AN/A
EL0616 IPS1 N/A Populus tremulaN/AN/A
EL0617 IPS1 N/A Vitis viniferaN/AN/A
EL0618 IPW NCRNA00002 Homo sapiensNR_023915N/A
EL0619 IRAIN IGF1R-AS Homo sapiensNR_126453ENSG00000259424
EL0620 JADRR lncRNA-JADE Homo sapiensN/AN/A
EL0621 JPX DCBALD06; ENOX; LINC00183; NCRNA00183 Homo sapiensNR_024582ENSG00000225470
EL0622 Jpx 2010000I03Rik; 2510040I06Rik; Enox Mus musculusNR_015508ENSMUSG00000097571
EL0623 Kcna2-AS Kcna2 antisense RNA Homo sapiensN/AN/A
EL0624 KCNE2 ATFB4; LQT5; LQT6; MIRP1 Homo sapiensN/AENSG00000159197
EL0625 KCNIP4-IT1 NCRNA00099; UM9(5); UM9-5 Homo sapiensNR_002813ENSG00000280650
EL0626 KCNIP4-IT1 UM9-5; NCRNA00099; KCNIP4-IT1 Sus scrofaN/AN/A
EL0627 KCNQ1DN BWRT; HSA404617 Homo sapiensNR_024627ENSG00000237941
EL0628 KCNQ1OT1 KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 Homo sapiensNR_002728ENSG00000269821
EL0629 Kcnq1ot1 Kvlqt1-as; Lit1; Tssc8 Mus musculusNR_001461ENSMUSG00000101609
EL0630 Khps1 N/A Homo sapiensN/AN/A
EL0631 Khps1a Khps1 Rattus norvegicusNR_133650N/A
EL0632 KIR antisense lncRNA N/A Homo sapiensN/AN/A
EL0633 KRAS1P KRAS1P; c-Kras1 Homo sapiensN/AN/A
EL0634 KRT18P55 N/A Homo sapiensNR_028334ENSG00000265480
EL0635 KRT19P3 N/A Homo sapiensN/AENSG00000249681
EL0636 Ks-1 N/A Apis melliferaNR_003567N/A
EL0637 LA16c-313D11.11 N/A Homo sapiensN/AN/A
EL0638 LALR N/A Homo sapiensN/AN/A
EL0639 LBX2-AS1 N/A Homo sapiensNR_024606ENSG00000257702
EL0640 LCAL1 onco-lncRNA-27 Homo sapiensNR_130915N/A
EL0641 LDMAR N/A Hybrid riceJQ317784N/A
EL0642 LDMAR N/A Oryza sativaN/AN/A
EL0643 LeENOD40 N/A Solanum lycopersicumAY388519N/A
EL0644 LEIGC N/A Homo sapiensN/AN/A
EL0645 LGALS3 CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2 Homo sapiensNR_003225ENSG00000131981
EL0646 LINC00032 C9orf14; NCRNA00032 Homo sapiensNR_026679ENSG00000283945
EL0647 LINC00160 C21orf52; NCRNA00160 Homo sapiensNR_024351ENSG00000230978
EL0648 LINC00173 NCRNA00173 Homo sapiensNR_027345, NR_027346ENSG00000196668
EL0649 LINC00210 NCRNA00210 Homo sapiensNR_048550ENSG00000231814
EL0650 LINC00237 NCRNA00237 Homo sapiensN/AN/A
EL0651 LINC00261 ALIEN; C20orf56; DEANR1; HCCDR1; NCRNA00261; onco-lncRNA-17 Homo sapiensNR_001558ENSG00000259974
EL0652 LINC00271 C6orf217; NCRNA00271 Homo sapiensNR_026805ENSG00000231028
EL0653 LINC00299 C2orf46; NCRNA00299 Homo sapiensNR_034135ENSG00000236790
EL0654 LINC00312 ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 Homo sapiensNR_024065N/A
EL0655 LINC00313 C21orf84; CH507-42P11.5; NCRNA00313 Homo sapiensNR_026863ENSG00000185186
EL0656 LINC00461 EyeLinc1; VISC; Visc-1a; Visc-1b; Visc-2 Homo sapiensNR_015436, NR_024383, NR_024384ENSG00000245526
EL0657 LINC00467 C1orf97 Homo sapiensNR_026761ENSG00000153363
EL0658 LINC00473 C6orf176; bA142J11.1 Homo sapiensNR_026861, NR_026860ENSG00000223414
EL0659 LINC00491 BC008363; LINC00491 Homo sapiensNR_103756, NR_103755, NR_103754, NR_103753ENSG00000250682
EL0660 LINC00538 PROX1UT; Yiya Homo sapiensNR_046189ENSG00000281664
EL0661 LINC00570 ncRNA-a5 Homo sapiensNR_047499ENSG00000224177
EL0662 LINC00581 linc-MBOAT1-4 Homo sapiensNR_103790ENSG00000280989
EL0663 LINC00635 LINC00635-001 Homo sapiensNR_024276, NR_015414ENSG00000241469
EL0664 LINC00659 CCAT4; LINC00659-001 Homo sapiensNR_046225, NR_046224ENSG00000228705
EL0665 LINC00663 Long Intergenic Non-Protein Coding RNA 663; CTC-559E9.1 Homo sapiensNR_026956N/A
EL0666 LINC00668 Long Intergenic Non-Protein Coding RNA 668 Homo sapiensNR_034100ENSG00000265933
EL0667 LINC00673 HI-LNC75; HILNC75; LUCAIR1; SLNCR; SLNCR1 Homo sapiensNR_036488N/A
EL0668 LINC00850 KUCG1 Homo sapiensNR_109813ENSG00000280752
EL0669 LINC00853 PDZK1IP1-AS1; ncRNA-a4 Homo sapiensNR_047498ENSG00000224805
EL0670 LINC00901 LSAMP-AS4; TCONS_00005428 Homo sapiensNR_121607ENSG00000242385
EL0671 LINC00942 LOC100292680; LINC00942 Homo sapiensNR_028415ENSG00000249628
EL0672 LINC00951 N/A Homo sapiensNR_038887N/A
EL0673 LINC00963 N/A Homo sapiensNR_038955ENSG00000204054
EL0674 LINC00964 N/A Homo sapiensNR_027321ENSG00000249816
EL0675 LINC00970 AK126698 Homo sapiensNR_104091ENSG00000203601
EL0676 LINC00974 N/A Homo sapiensNR_038442ENSG00000226629
EL0677 LINC00982 LINC00982; FLJ42875 Homo sapiensNR_015440, NR_024371ENSG00000177133
EL0678 LINC00987 LOC100499405; LINC00987 Homo sapiensNR_036466ENSG00000237248
EL0679 LINC01016 Long Intergenic Non-Protein Coding RNA 1016 Homo sapiensNR_038989ENSG00000249346
EL0680 LINC01018 SRHC Homo sapiensNR_024423, NR_024424ENSG00000250056
EL0681 LINC01021 N/A Homo sapiensNR_038848ENSG00000250337
EL0682 LINC01024 MA-linc1 Homo sapiensNR_102741, NR_102740, NR_102739ENSG00000245146
EL0683 SLC44A3-AS1 LINC01057 Homo sapiensNR_104131ENSG00000224081
EL0684 LINC01105 LOC150622; LINC01105; FLJ30594 Homo sapiensNR_026832ENSG00000232044
EL0685 LINC01125 LINC01125 Homo sapiensNR_038386ENSG00000228486
EL0686 LINC01133 N/A Homo sapiensNR_038849ENSG00000224259
EL0687 LINC01158 PANTR1; linc-Brn1a; linc-POU3F3 Homo sapiensNR_037883, NR_131233, NR_131234, NR_131235ENSG00000233639
EL0688 LINC01207 N/A Homo sapiensNR_038834ENSG00000248771
EL0689 LINC01225 LOC149086; LINC01225 Homo sapiensNR_034112ENSG00000260386
EL0690 LINC01233 XLOC_013014 Homo sapiensNR_110663, NR_110664ENSG00000269364
EL0691 LINC01262 LINC01262; RP11-462G22.1 Homo sapiensNR_121679ENSG00000250739
EL0692 LINC01315 lnc-C22orf32-1 Homo sapiensNR_120597, NR_120596, NR_120595ENSG00000229891
EL0693 LINC01370 HI-LNC25; HILNC25 Homo sapiensNR_109936, NR_109937ENSG00000237767
EL0694 LINC01419 LVCAT7; TCONS_00014497 Homo sapiensNR_122034ENSG00000253898
EL0695 LINC01426 lincRNA-uc002yug.2 Homo sapiensNR_038885, NR_038886ENSG00000234380
EL0696 LINC01433 LOC728228; LINC01433 Homo sapiensNR_033917ENSG00000230176
EL0697 LINC01451 HCCAT4 Homo sapiensNR_135288ENSG00000279141
EL0698 LINC01468 lnc-MBL2-4 Homo sapiensNR_120641, NR_120642ENSG00000231131
EL0699 LINC01503 lnc-PPP2R4-5; LINC01503 Homo sapiensNR_120685, NR_120686ENSG00000233901
EL0700 LINC01511 LINC01511; RP11-325I22.2 Homo sapiensNR_125810ENSG00000250584
EL0701 LINC01512 HI-LNC77 Homo sapiensNR_024478N/A
EL0702 LINC01527 lnc-SPRR2D-1 Homo sapiensXR_241125ENSG00000224308
EL0703 LINC01550 C14orf64 Homo sapiensNR_015430ENSG00000246223
EL0704 LINC01564 TCONS_00011314; XLOC_005327 Homo sapiensNR_125841ENSG00000235899
EL0705 LINC01613 n341773 Homo sapiensNR_132393ENSG00000261432
EL0706 LINC01616 n341006 Homo sapiensNR_132652ENSG00000261340
EL0707 LINC01617 C8orf23; NCRNA00249; XLOC_006844 Homo sapiensNR_147034N/A
EL0708 LINC01618 LOC152578; RP11-752D24.3 Homo sapiensNR_040106ENSG00000250302
EL0709 LINC01628 N/A Homo sapiensNR_110600ENSG00000232688
EL0710 LINC01630 Uncharacterized LOC100287225 Homo sapiensNR_040074, NR_040075ENSG00000227115
EL0711 LINC02 N/A Gossypium barbadenseN/AN/A
EL0712 linc1242 linc-Enah Mus musculusN/AN/A
EL0713 linc1257 Linc-Myo1g; Ak160548 Mus musculusN/AN/A
EL0714 linc1368 linc-Adamts9 Mus musculusN/AN/A
EL0715 linc-CBR1-2 N/A Homo sapiensN/AN/A
EL0716 lincDR1 N/A Homo sapiensN/AN/A
EL0717 lincGARS N/A Homo sapiensN/AN/A
EL0718 linc-ITGB1 linc-ITGB1 Homo sapiensN/AENSG00000150093
EL0719 LINCMD1 LINC-MD1; MIR133BHG Homo sapiensNR_131248N/A
EL0720 lincMLKN1 N/A Homo sapiensN/AN/A
EL0721 LINC-PINT LincRNA-Pint; MKLN1-AS1; PINT Homo sapiensNR_110473, NR_110472, NR_034120, NR_109855, NR_109854, NR_109853, NR_015431, NR_109852, NR_109851, NENSG00000231721
EL0722 Linc-rbe N/A Rattus norvegicusN/AN/A
EL0723 LincR-Ccr2-5'AS N/A Mus musculusN/AN/A
EL0724 lincRNA1039 N/A Populus trichocarpaN/AN/A
EL0725 lincRNA1085 N/A Populus trichocarpaN/AN/A
EL0726 lincRNA1128 N/A Populus trichocarpaN/AN/A
EL0727 lincRNA1310 N/A Populus trichocarpaN/AN/A
EL0728 lincRNA1534 N/A Populus trichocarpaN/AN/A
EL0729 lincRNA1828 N/A Populus trichocarpaN/AN/A
EL0730 lincRNA20 N/A Populus trichocarpaN/AN/A
EL0731 lincRNA2085 N/A Populus trichocarpaN/AN/A
EL0732 lincRNA2131 N/A Populus trichocarpaN/AN/A
EL0733 lincRNA2198 N/A Populus trichocarpaN/AN/A
EL0734 lincRNA262 N/A Populus trichocarpaN/AN/A
EL0735 lincRNA2623 N/A Populus trichocarpaN/AN/A
EL0736 lincRNA2752 N/A Populus trichocarpaN/AN/A
EL0737 lincRNA2962 N/A Populus trichocarpaN/AN/A
EL0738 lincRNA3241 N/A Populus trichocarpaN/AN/A
EL0739 lincRNA-BC2 N/A Homo sapiensN/AN/A
EL0740 lincRNA-BC4 N/A Homo sapiensN/AN/A
EL0741 lincRNA-BC5 N/A Homo sapiensN/AN/A
EL0742 lincRNA-BC8 N/A Homo sapiensN/AN/A
EL0743 lincRNA-CALCA N/A Homo sapiensN/AN/A
EL0744 lincRNA-LALR1 LncRNA-LALR1 Homo sapiensN/AN/A
EL0745 lincRNA-TSPAN8 N/A Homo sapiensN/AN/A
EL0746 lincRNA-ZNF532 N/A Homo sapiensN/AN/A
EL0747 LINC-ROR ROR; lincRNA-RoR Homo sapiensNR_048536ENSG00000258609
EL0748 LINC-RSAS repeat-rich sense-antisense transcript Rattus norvegicusN/AN/A
EL0749 lincSFPQ N/A Homo sapiensN/AN/A
EL0750 LINK-A N/A Homo sapiensN/AN/A
EL0751 LL34 N/A Homo sapiensN/AN/A
EL0752 Llme23 N/A Homo sapiensN/AN/A
EL0753 lnc13 N/A Homo sapiensN/AN/A
EL0754 lnc-168 N/A Arabidopsis thalianaN/AN/A
EL0755 lnc-173 N/A Arabidopsis thalianaN/AN/A
EL0756 lnc-225 N/A Arabidopsis thalianaN/AN/A
EL0757 lnc-31 N/A Mus musculusN/AN/A
EL0758 Lnc34a N/A Homo sapiensN/AN/A
EL0759 lnc-508 N/A Arabidopsis thalianaN/AN/A
EL0760 lnc-ACACA-1 N/A Homo sapiensN/AN/A
EL0761 lnc-AF085935 N/A Homo sapiensN/AN/A
EL0762 lnc-AL355149.1-1 N/A Homo sapiensN/AENSG00000266584
EL0763 lncARSR N/A Homo sapiensN/AN/A
EL0764 lnc-bc060912 N/A Homo sapiensN/AN/A
EL0765 lnc-BMP2-2 N/A Homo sapiensN/AN/A
EL0766 lnc-CPN2-1 N/A Homo sapiensN/AN/A
EL0767 lnc-CYP4A22-2/3 N/A Homo sapiensN/AN/A
EL0768 lnc-DILC N/A Homo sapiensN/AN/A
EL0769 lnc-FOXG1-2 N/A Homo sapiensN/AN/A
EL0770 lnc-FZD1-2 N/A Homo sapiensN/AN/A
EL0771 lnc-ITPR2-3 N/A Homo sapiensN/AN/A
EL0772 lnc-KCMF1-2:1 N/A Homo sapiensN/AN/A
EL0773 lnc-LCE5A-1 N/A Homo sapiensN/AN/A
EL0774 lnc-LCP2-2 N/A Homo sapiensN/AN/A
EL0775 lncLGR N/A Mus musculusAK028540N/A
EL0776 lnc-LLPH-2:1 N/A Homo sapiensN/AN/A
EL0777 lnc-MX1-1 N/A Homo sapiensN/AN/A
EL0778 lnc-PLA2R1-1:1 N/A Homo sapiensN/AN/A
EL0779 lnc-PSD4-1:14 N/A Homo sapiensN/AN/A
EL0780 lncRNA1329 N/A Solanum lycopersicumN/AN/A
EL0781 lncRNA1459 N/A Solanum lycopersicumN/AN/A
EL0782 lncRNA1471 N/A Solanum lycopersicumN/AN/A
EL0783 lncRNA1785 N/A Solanum lycopersicumN/AN/A
EL0784 lncRNA1840 N/A Solanum lycopersicumN/AN/A
EL0785 lncRNA2.7 HHV5gp156 Human herpesvirus 5N/AN/A
EL0786 lncRNA246 N/A Solanum lycopersicumN/AN/A
EL0787 lncRNA2943 N/A Solanum lycopersicumN/AN/A
EL0788 LncRNA-314 N/A Solanum lycopersicum and S. pimpinellifoliumN/AN/A
EL0789 lncRNA3294 N/A Solanum lycopersicumN/AN/A
EL0790 lncRNA3613 N/A Solanum lycopersicumN/AN/A
EL0791 lncRNA-422 N/A Homo sapiensN/AN/A
EL0792 lncRNA496 N/A Solanum lycopersicumN/AN/A
EL0793 lncRNA504 N/A Solanum lycopersicumN/AN/A
EL0794 lncRNA506 N/A Solanum lycopersicumN/AN/A
EL0795 lncRNA864 N/A Solanum lycopersicumN/AN/A
EL0796 lncRNA950 N/A Solanum lycopersicumN/AN/A
EL0797 lncRNA-AK058803 N/A Homo sapiensN/AN/A
EL0798 LncRNA-AP001631.9 N/A Homo sapiensN/AENSG00000236663
EL0799 lncRNA-ATB N/A Homo sapiensN/AN/A
EL0800 lncRNA-DQ786227 N/A Homo sapiensN/AN/A
EL0801 lncRNA-HSVIII N/A Mus musculusN/AN/A
EL0802 lncRNA-n336928 N/A Homo sapiensN/AN/A
EL0803 lncRNA-Rel N/A Mus musculusN/AN/A
EL0804 lncRNA-αGT N/A Gallus gallusN/AN/A
EL0805 lnc-RP3-368B9 N/A Homo sapiensN/AN/A
EL0806 lnc-SLC30A4-1 N/A Homo sapiensN/AN/A
EL0807 lnc-SPAM1-6 N/A Homo sapiensN/AN/A
EL0808 lnc-TTC34-3 N/A Homo sapiensN/AN/A
EL0809 lnc-uc003wbd N/A Homo sapiensN/AN/A
EL0810 lnc-ZNF180-2 lnc-ZNF180-2 Homo sapiensN/AENSG00000167384
EL0811 lnc-ZNF674-1 N/A Homo sapiensN/AN/A
EL0812 LOC100129973 RP11-430B1.2 Homo sapiensNR_102751ENSG00000259577
EL0813 LOC100131831 N/A Homo sapiensN/AN/A
EL0814 LOC100287482 LOC100287482; SMKR1 Homo sapiensN/AENSG00000240204
EL0815 LOC100288798 N/A Homo sapiensNR_125378, NR_125379, NR_125377, NR_125380, NR_125381N/A
EL0816 LOC100506974 N/A Homo sapiensXR_001752796, XR_001752794, XR_001752797, XR_001752795N/A
EL0817 LOC101211037 CR20 Cucumis sativusXR_969194, XR_969192, XR_969189, XR_969193, XR_969191, XR_969190, XR_969187, XR_969188, XR_969185, XN/A
EL0818 LINC01844 Uncharacterized LOC101926975 Homo sapiensNR_110558ENSG00000236714
EL0819 LOC101927497 LOC101927497 Homo sapiensNR_110086, NR_110087, NR_110088ENSG00000237819
EL0820 LOC103643717 TCONS_00011169 Zea maysXR_561214N/A
EL0821 LOC103692984 N/A Rattus norvegicusNR_132098ENSRNOG00000060019
EL0822 LOC105246506 N/A Mus musculusNR_131039N/A
EL0823 LOC105372753 N/A Homo sapiensXR_001754985, XR_001754984, XR_001754986, XR_001754987, XR_001754983ENSG00000229962
EL0824 LOC105374631 CTD-2247C11.5-001; ENST00000507950 Homo sapiensNR_134266ENSG00000250529
EL0825 LOC105377769 CTC-338M12.5; ENST00000514487 Homo sapiensXR_941333, XR_941334ENSG00000250222
EL0826 LOC105435934 CsM10 Cucumis sativusXR_969890, XR_969892, XR_969891, XR_969893, XR_969894N/A
EL0827 LOC389023 N/A Homo sapiensN/AN/A
EL0828 LOC389332 NR_024418; AC009014.3-001 Homo sapiensNR_024418ENSG00000271824
EL0829 AC100861.1 RP11-1149O23.3 Homo sapiensNR_033928ENSG00000246582
EL0830 LOC400891 N/A Homo sapiensN/AN/A
EL0831 LOC401317 N/A Homo sapiensN/AN/A
EL0832 LOC548136 enod40 Hordeum vulgareAF542513N/A
EL0833 LOC652276 NR_015441; AC141586.5-002 Homo sapiensNR_015441ENSG00000215154
EL0834 LpENOD40 N/A Lolium perenneAF538350N/A
EL0835 Lrrc9 4921529O18Rik; 4930432K16Rik Mus musculusAK144081.1ENSMUSG00000021090
EL0836 LSINCT1 N/A Homo sapiensN/AN/A
EL0837 LSINCT10 N/A Homo sapiensN/AN/A
EL0838 LSINCT11 N/A Homo sapiensN/AN/A
EL0839 LSINCT12 N/A Homo sapiensN/AN/A
EL0840 LSINCT2 N/A Homo sapiensN/AN/A
EL0841 LSINCT3 N/A Homo sapiensN/AN/A
EL0842 LSINCT4 N/A Homo sapiensN/AN/A
EL0843 LSINCT5 N/A Homo sapiensNR_145480ENSG00000281560
EL0844 LSINCT6 N/A Homo sapiensN/AN/A
EL0845 LSINCT7 N/A Homo sapiensN/AN/A
EL0846 LSINCT8 N/A Homo sapiensN/AN/A
EL0847 LSINCT9 N/A Homo sapiensN/AN/A
EL0848 LUADT1 N/A Homo sapiensNR_132442ENSG00000196634
EL0849 LUCAT1 SCAL1 Homo sapiensNR_103548, NR_103549ENSG00000248323
EL0850 LUNAR1 Leukemia-Associated Non-Coding IGF1R Activator RNA 1; RP11-6O2.2 Homo sapiensNR_126487ENSG00000278090
EL0851 M14574 N/A Homo sapiensN/AN/A
EL0852 MAFA-AS1 TCONS_00014882 Homo sapiensNR_126358ENSG00000254338
EL0853 MALAT1 HCN; LINC00047; NCRNA00047; NEAT2; PRO2853; mascRNA Homo sapiensNR_002819ENSG00000251562
EL0854 Malat1 2210401K01Rik; 9430072K23Rik; AI647968; Neat2 Mus musculusNR_002847ENSMUSG00000092341
EL0855 MALAT2 N/A Homo sapiensN/AN/A
EL0856 MAP3K14 FTDCR1B; HS; HSNIK; NIK Homo sapiensXR_934591ENSG00000006062
EL0857 MAR N/A Panax ginsengAF485333N/A
EL0858 Maternal somatic nucleus RNAs Paramecium tetraurelia maternal macronucleus noncoding RNAs Paramecium tetraureliaN/AN/A
EL0859 MDC1-AS1 MDC1-AS Homo sapiensNR_133647ENSG00000224328
EL0860 Mdrl 2310010G23Rik Mus musculusNR_131979ENSMUSG00000097468
EL0861 MEG3 FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 Homo sapiensNR_046467, NR_046465, NR_046472, NR_046471, NR_033359, NR_003530, NR_033358, NR_002766, NR_046470, NENSG00000214548
EL0862 Meg3 2900016C05Rik; 3110050O07Rik; 6330408G06Rik; AI425946; AW108224; D12Bwg1266e; Gtl2; R74756; R75394 Mus musculusNR_027652, NR_027651, NR_003633ENSMUSG00000021268
EL0863 MEG8 Bsr; Rian Rattus norvegicusN/AN/A
EL0864 MESTIT1 MEST-AS1; MEST-IT; MEST-IT1; NCRNA00040; PEG1-AS Homo sapiensNR_004382N/A
EL0865 MHM N/A Gallus gallusN/AN/A
EL0866 MHM-lncRNA N/A Gallus gallusN/AN/A
EL0867 MHRT Myheart Homo sapiensNR_126491ENSG00000258444
EL0868 Mhrt D830015G02Rik; ENSMUSG00000053118; Myheart Mus musculusNR_033497ENSMUSG00000097652
EL0869 MIAT C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT Homo sapiensNR_003491, NR_033319, NR_033320, NR_033321ENSG00000225783
EL0870 Miat 3632434I06; A230057G18Rik; Rncr2; gomafu Mus musculusNR_003718, NR_033657ENSMUSG00000097767
EL0871 MIAT RNCR2/MIAT Gallus gallusN/AN/A
EL0872 MINA MDIG53; NO52; ROX; MINA Homo sapiensXR_001740332, XR_241516, XR_001740331ENSG00000170854
EL0873 MINCR LINC01604 Homo sapiensNR_120682, NR_120683ENSG00000253716
EL0874 MIR100HG AGD1; linc-NeD125; lncRNA-N2 Homo sapiensNR_024430ENSG00000255248
EL0875 Mir124a-1hg A930011O12Rik; Rncr3; mir-124-1; mir-3078 Mus musculusNR_040709ENSMUSG00000097545
EL0876 Mir142hg A430104N18Rik; AW909330 Mus musculusBE136127ENSMUSG00000084796
EL0877 MIR155HG BIC; MIRHG2; NCRNA00172 Homo sapiensNR_001458ENSG00000234883
EL0878 MIR17HG C13orf25; FGLDS2; LINC00048; MIHG1; MIRH1; MIRHG1; NCRNA00048; miR-17-92 Homo sapiensNR_027350, NR_027349ENSG00000215417
EL0879 MIR21 MIRN21; hsa-mir-21; miR-21; miRNA21 Homo sapiensNR_029493N/A
EL0880 MIR31HG LOC554202; MIR31HG Homo sapiensNR_027054ENSG00000171889
EL0881 MIR4435-2HG AGD2; AK001796; LINC00978; MIR4435-1HG Homo sapiensNR_136164, NR_136163, NR_136162, NR_136165, NR_136161, NR_136166, NR_015395, NR_024373ENSG00000172965
EL0882 MIR7-3HG C19orf30; Huh7; LINC00306; NCRNA00306; PGSF1; uc002mbe.2 Homo sapiensNR_027148ENSG00000176840
EL0883 MIR99AHG C21orf34; C21orf35; LINC00478; MONC Homo sapiensNR_136541, NR_136542, NR_027790, NR_111005, NR_111004, NR_136552, NR_136551, NR_027791, NR_136543, NENSG00000215386
EL0884 Mira Mira Mus musculusNR_045199N/A
EL0885 MKRN3-AS1 FNZ127; MKRN3-AS; MKRN3AS; NCRNA00009; ZNF127-AS; ZNF127AS Homo sapiensN/AN/A
EL0886 mlncR1 N/A Digitalis purpureaJO460015N/A
EL0887 mlncR1 N/A Salvia miltiorrhizaN/AN/A
EL0888 mlncR10 N/A Digitalis purpureaJO460027N/A
EL0889 mlncR10 N/A Salvia miltiorrhizaN/AN/A
EL0890 mlncR11 N/A Salvia miltiorrhizaN/AN/A
EL0891 mlncR12 N/A Digitalis purpureaJO464553N/A
EL0892 mlncR13 N/A Digitalis purpureaJO461863N/A
EL0893 mlncR13 N/A Salvia miltiorrhizaN/AN/A
EL0894 mlncR14 N/A Digitalis purpureaJO460868N/A
EL0895 mlncR14 N/A Salvia miltiorrhizaN/AN/A
EL0896 mlncR15 N/A Digitalis purpureaJO460756N/A
EL0897 mlncR15 N/A Salvia miltiorrhizaN/AN/A
EL0898 mlncR16 N/A Digitalis purpureaJO461597N/A
EL0899 mlncR16 N/A Salvia miltiorrhizaN/AN/A
EL0900 mlncR17 N/A Digitalis purpureaJO464502N/A
EL0901 mlncR17 N/A Salvia miltiorrhizaN/AN/A
EL0902 mlncR18 N/A Digitalis purpureaJO460757N/A
EL0903 mlncR18 N/A Salvia miltiorrhizaN/AN/A
EL0904 mlncR19 N/A Digitalis purpureaJO461384N/A
EL0905 mlncR2 N/A Digitalis purpureaJO460538N/A
EL0906 mlncR2 N/A Salvia miltiorrhizaN/AN/A
EL0907 mlncR20 N/A Digitalis purpureaJO462548N/A
EL0908 mlncR21 N/A Digitalis purpureaJO460109N/A
EL0909 mlncR22 N/A Digitalis purpureaJO463958N/A
EL0910 mlncR23 N/A Digitalis purpureaJO460543N/A
EL0911 mlncR24 N/A Digitalis purpureaJO460800N/A
EL0912 mlncR25 N/A Digitalis purpureaJO463091N/A
EL0913 mlncR26 N/A Digitalis purpureaJO467391N/A
EL0914 mlncR27 N/A Digitalis purpureaJO463416N/A
EL0915 mlncR28 N/A Digitalis purpureaJO460815N/A
EL0916 mlncR29 N/A Digitalis purpureaJO460003N/A
EL0917 mlncR3 N/A Digitalis purpureaJO467387N/A
EL0918 mlncR3 N/A Salvia miltiorrhizaN/AN/A
EL0919 mlncR30 N/A Digitalis purpureaJO462174N/A
EL0920 mlncR31 N/A Digitalis purpureaJO463507N/A
EL0921 mlncR4 N/A Digitalis purpureaJO460228N/A
EL0922 mlncR4 N/A Salvia miltiorrhizaN/AN/A
EL0923 mlncR5 N/A Digitalis purpureaJO460314N/A
EL0924 mlncR5 N/A Salvia miltiorrhizaN/AN/A
EL0925 mlncR6 N/A Digitalis purpureaJO460006N/A
EL0926 mlncR6 N/A Salvia miltiorrhizaN/AN/A
EL0927 mlncR7 N/A Digitalis purpureaJO460072N/A
EL0928 mlncR7 N/A Salvia miltiorrhizaN/AN/A
EL0929 mlncR8 N/A Digitalis purpureaJO463019N/A
EL0930 mlncR8 N/A Salvia miltiorrhizaN/AN/A
EL0931 mlncR9 N/A Salvia miltiorrhizaN/AN/A
EL0932 MNX1-AS1 CCAT5 Homo sapiensNR_038835ENSG00000243479
EL0933 MR1 HLALS Homo sapiensN/AENSG00000153029
EL0934 MRAK052686 N/A Homo sapiensN/AN/A
EL0935 MsENOD40-1 N/A Medicago sativaAF035556N/A
EL0936 MsENOD40-2 N/A Medicago sativaAF035557N/A
EL0937 MSUR1 N/A Mus musculusN/AN/A
EL0938 Msx1 AA675338; AI324650; Hox-7; Hox7; Hox7.1; msh Mus musculusN/AENSMUSG00000048450
EL0939 Msx1os Msx1as Mus musculusNR_027920N/A
EL0940 MT1DP MTM Homo sapiensNR_027781, NR_003658ENSG00000205361
EL0941 MT1JP MT1; MT1J; MT1NP; MTB Homo sapiensNR_036677ENSG00000255986
EL0942 Mt4 N/A Barrel cloverN/AN/A
EL0943 Mt4 N/A Medicago sativaN/AN/A
EL0944 Mt4 N/A Medicago truncatulaU76742N/A
EL0945 MtENOD40-1 N/A Medicago truncatulaN/AN/A
EL0946 MtENOD40-2 N/A Medicago truncatulaX80262N/A
EL0947 MT-ND5 MTND5; ND5 Homo sapiensN/AN/A
EL0948 MT-ND6 MTND6; ND6 Homo sapiensN/AN/A
EL0949 Munc DRReRNA Mus musculusNR_131190N/A
EL0950 MVIH N/A Homo sapiensN/AN/A
EL0951 MYCNOS MYCN-AS1; N-CYM; NCYM; NYCM Homo sapiensNR_110230ENSG00000233718
EL0952 MYCNUT MYCNUN; lncUSMycN Homo sapiensNR_125783ENSG00000223850
EL0953 Myh8 4832426G23Rik; AI327267; MHCp; MyHC-pn; Myhs-p; Myhsp Mus musculusN/AENSMUSG00000055775
EL0954 MYHAS ASLNC11435; AK097500 Homo sapiensNR_125367N/A
EL0955 MYLK-AS1 N/A Homo sapiensNR_038266, NR_121654ENSG00000239523
EL0956 n335550 N/A Homo sapiensN/AN/A
EL0957 n340790 N/A Homo sapiensN/AN/A
EL0958 n386477 N/A Homo sapiensN/AN/A
EL0959 NALT1 LINC01573; MIR4674HG; NALT Homo sapiensNR_121577ENSG00000237886
EL0960 NAMA N/A Homo sapiensNR_102271, NR_102270ENSG00000271086
EL0961 NBAT1 CASC14; NBAT-1 Homo sapiensNR_034143ENSG00000260455
EL0962 NBR2 NCRNA00192 Homo sapiensNR_003108ENSG00000198496
EL0963 ncC11orf49 N/A Homo sapiensN/AN/A
EL0964 ncHDAC5 N/A Homo sapiensN/AN/A
EL0965 ncNRFR N/A Homo sapiensN/AN/A
EL0966 ncRAB31 N/A Homo sapiensN/AN/A
EL0967 ncRNA-a6 N/A Homo sapiensN/AN/A
EL0968 ncRNACCND1 N/A Homo sapiensN/AN/A
EL0969 NCRUPAR NCRNA00193; ncR-uPAR Homo sapiensNR_028375N/A
EL0970 ncSRPK1 N/A Homo sapiensN/AN/A
EL0971 Nctc1 9530074L01; Rhit1 Mus musculusNR_002452ENSMUSG00000087090
EL0972 NDM29 N/A Homo sapiensN/AN/A
EL0973 NEAT1 LINC00084; NCRNA00084; TncRNA; VINC Homo sapiensNR_131012, NR_028272ENSG00000245532
EL0974 Neat1 2310043N10Rik; VINC Mus musculusNR_131212, NR_003513ENSMUSG00000092274
EL0975 Nespas Gnas-as; Nespos Mus musculusNR_002846ENSMUSG00000086537
EL0976 Nfkb2 NF-kappaB2; lyt; p49; p49/p100; p50B; p52 Mus musculusN/AENSMUSG00000025225
EL0977 NKILA N/A Homo sapiensNR_131157ENSG00000278709
EL0978 Nkx2-2os Gm14112; Nkx2-2as; Nkx2.2AS Mus musculusNR_030769ENSMUSG00000086509
EL0979 NONHSAT012762 N/A Homo sapiensN/AN/A
EL0980 NONHSAT037832 N/A Homo sapiensN/AN/A
EL0981 NONHSAT073641 N/A Homo sapiensN/AN/A
EL0982 NONHSAT123350 N/A Homo sapiensN/AN/A
EL0983 NONHSAT125629 N/A Homo sapiensN/AN/A
EL0984 NONRATT021972 N/A Rattus norvegicusN/AN/A
EL0985 NORAD LINC00657 Homo sapiensNR_027451ENSG00000260032
EL0986 NOS2 HEP-NOS; INOS; NOSA; NOS2 Homo sapiensN/AENSG00000007171
EL0987 np_17856 N/A Mus musculusN/AN/A
EL0988 np_5318 N/A Mus musculusN/AN/A
EL0989 NPAP1 C15orf2 Homo sapiensN/AENSG00000185823
EL0990 npc15 N/A Arabidopsis thalianaN/AN/A
EL0991 npc156 N/A Arabidopsis thalianaN/AN/A
EL0992 npc311 N/A Arabidopsis thalianaN/AN/A
EL0993 npc33 N/A Arabidopsis thalianaN/AN/A
EL0994 npc34 N/A Arabidopsis thalianaN/AN/A
EL0995 npc351 N/A Arabidopsis thalianaN/AN/A
EL0996 npc375 N/A Arabidopsis thalianaN/AN/A
EL0997 npc43 N/A Arabidopsis thalianaN/AN/A
EL0998 npc48 N/A Arabidopsis thalianaHG975424N/A
EL0999 npc523 N/A Arabidopsis thalianaN/AN/A
EL1000 npc531 N/A Arabidopsis thalianaN/AN/A
EL1001 npc536 N/A Arabidopsis thalianaHG975425N/A
EL1002 npc60 N/A Arabidopsis thalianaN/AN/A
EL1003 npc78 N/A Arabidopsis thalianaN/AN/A
EL1004 npc82 N/A Arabidopsis thalianaN/AN/A
EL1005 npc83 N/A Arabidopsis thalianaN/AN/A
EL1006 NPPA-AS1 NPPA-AS; NPPAAS Homo sapiensNR_037806N/A
EL1007 NPTN-IT1 lncRNA-LET Homo sapiensNR_103844ENSG00000281183
EL1008 NR_038125 N/A Homo sapiensN/AN/A
EL1009 NR024118 N/A Rattus norvegicusN/AN/A
EL1010 NRAV DYNLL1-AS1; DYNLL1AS1 Homo sapiensNR_038854ENSG00000248008
EL1011 NRG1 ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF-IT2; SMDF; NRG1 Homo sapiensN/AENSG00000157168
EL1012 NRIR lncRNA-CMPK2 Homo sapiensNR_126359ENSG00000225964
EL1013 NRON NCRNA00194 Homo sapiensNR_045006N/A
EL1014 NRSE N/A Hippocampus comesN/AN/A
EL1015 nta-eTMX27 N/A Nicotiana tabacumN/AN/A
EL1016 NtENOD40-1 N/A Nicotiana tabacumN/AN/A
EL1017 NUTF2P3 NUTF2P3-001 Homo sapiensN/AENSG00000228248
EL1018 ObENOD40 N/A Oryza brachyanthaAB024055N/A
EL1019 OGT HINCUT-1; HRNT1; O-GLCNAC Homo sapiensN/AENSG00000147162
EL1020 OIP5-AS1 cyrano Homo sapiensNR_026757ENSG00000247556
EL1021 OR3A4P OLFRA05; OLFRA06; OR17-13; OR17-16; OR17-24; OR17-25; OR24; OR25; OR3A4; OR3A5P Homo sapiensNR_024128ENSG00000279517
EL1022 ORAOV1 TAOS1 Homo sapiensN/AENSG00000149716
EL1023 OS9 ERLEC2; OS-9 Homo sapiensN/AENSG00000135506
EL1024 OsIPS1 N/A Oryza sativaAY568759N/A
EL1025 osk Dmel_CG10901; CG10901; Dm-osk; DmelCG10901; OSK; Osk; Oskar; norka Drosophila melanogasterN/AN/A
EL1026 OsPI1 N/A Oryza sativaN/AN/A
EL1027 OVAAL LINC01131; OVAL Homo sapiensNR_125716ENSG00000236719
EL1028 P14695 N/A Homo sapiensN/AN/A
EL1029 P16984 N/A Homo sapiensN/AN/A
EL1030 P19780 N/A Homo sapiensN/AN/A
EL1031 P23099 N/A Homo sapiensN/AN/A
EL1032 P24363 N/A Homo sapiensN/AN/A
EL1033 P28210 N/A Homo sapiensN/AN/A
EL1034 P2rx3 N/A Rattus norvegicusNR_073054ENSRNOG00000008552
EL1035 P33863 N/A Homo sapiensN/AN/A
EL1036 P4091 N/A Homo sapiensN/AN/A
EL1037 P6391 N/A Homo sapiensN/AN/A
EL1038 P6488 N/A Homo sapiensN/AN/A
EL1039 P700 N/A Homo sapiensN/AN/A
EL1040 P8611 N/A Homo sapiensN/AN/A
EL1041 P8725 N/A Homo sapiensN/AN/A
EL1042 P8860 N/A Homo sapiensN/AN/A
EL1043 P9745 N/A Homo sapiensN/AN/A
EL1044 PACERR PACER; PTGS2-AS1 Homo sapiensNR_125801ENSG00000273129
EL1045 PAN CG17964; CG32005; CG34403; cTCF; d-TCF; Dm Pan; DmelCG34403; dTcf; dTCF; DTcf; DTCF; IA5; l(4)102ABb; l(4)13; Lef; LEF-1; LEF/TCF; LEF/TCF-1; lef1; Lef1; LEF1; LEF1/TCF; Pan; PAN; pan.dTCF; tcf; Tcf; TCF; Tcf-1; Tcf/LEF; TCF/LEF; TCF/LEF1 Homo sapiensN/AN/A
EL1046 PANDAR PANDA Homo sapiensNR_109836ENSG00000281450
EL1047 PARTICL PARTICLE Homo sapiensNR_038942N/A
EL1048 Paupar N/A Mus musculusNR_117095ENSMUSG00000102424
EL1049 PAWR PAR4; Par-4 Homo sapiensXR_944561, XR_944560ENSG00000177425
EL1050 PAX8-AS1 N/A Homo sapiensNR_047570, NR_015377ENSG00000189223
EL1051 PCA3 DD3; NCRNA00019; PCAT3 Homo sapiensNR_132312, NR_015342, NR_132313ENSG00000225937
EL1052 PCAT1 PCA1; PCAT-1 Homo sapiensNR_045262ENSG00000253438
EL1053 PCAT18 LINC01092 Homo sapiensNR_024259ENSG00000265369
EL1054 PCAT29 N/A Homo sapiensNR_126437, NR_126438ENSG00000259641
EL1055 PCAT5 LINC01452; TPCAT-10-36067 Homo sapiensNR_110138ENSG00000280719
EL1056 PCAT6 KDM5B-AS1; KDM5BAS1; PCAN-R1; ncRNA-a2; onco-lncRNA-96 Homo sapiensNR_046325, NR_046326ENSG00000228288
EL1057 PCAT7 PCAN-R2 Homo sapiensNR_121566, NR_121567, NR_121569, NR_121568ENSG00000231806
EL1058 PCGEM1 LINC00071; NCRNA00071; PCAT9 Homo sapiensNR_002769ENSG00000227418
EL1059 PCNA-AS1 PCNA-AS; PCNAAS Homo sapiensNR_028370N/A
EL1060 PCNCR1 N/A Homo sapiensN/AN/A
EL1061 PDLIM3 ALP Homo sapiensNR_047562ENSG00000154553
EL1062 PDZRN3-AS1 PDZRN3-AS1; Homo sapiensNR_046681N/A
EL1063 PEG10 EDR; HB-1; MEF3L; Mar2; Mart2; RGAG3 Homo sapiensN/AENSG00000242265
EL1064 pGmENOD40 N/A Pisum sativumX81064N/A
EL1065 PHO84 YML123C Saccharomyces cerevisiae S288cN/AN/A
EL1066 PHO84 antisense transcripts antisense transcripts Saccharomyces cerevisiae S288cN/AN/A
EL1067 PICSAR C21orf113; LINC00162; NCRNA00162; NLC1-C; NLC1C; PRED74 Homo sapiensNR_024089ENSG00000275874
EL1068 Pinc N/A Mus musculusNR_003202ENSMUSG00000099877
EL1069 Pinci1-1 N/A Phytophthora infestansN/AN/A
EL1070 PINK1-AS NAPINK11; PINK1AS; PINK1-AS Homo sapiensNR_046507ENSG00000117242
EL1071 PISRT1 NCRNA00195 Homo sapiensNR_027070ENSG00000281473
EL1072 Platr14 4930500J02Rik Mus musculusNR_040322, NR_040323ENSMUSG00000086454
EL1073 PLEC EBS1; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; PCN1; PLEC1b; PLTN; PLEC Homo sapiensN/AENSG00000178209
EL1074 PMS2P5 PMS2L5; PMS7 Homo sapiensNR_027777, NR_027775, NR_027776N/A
EL1075 pncRNA-D promoter-associated ncRNA-D Homo sapiensN/AN/A
EL1076 POT1-AS1 N/A Homo sapiensNR_125718, NR_125719ENSG00000224897
EL1077 linc-POU3F3 PANTR1; linc-Brn1a; linc-POU3F3 Homo sapiensNR_037883, NR_131233, NR_131234, NR_131235ENSG00000233639
EL1078 POU5F1P4 Oct4-pg4; POU5FLC1 Homo sapiensNR_034180ENSG00000237872
EL1079 POU6F2-AS2 POU6F2 Antisense RNA 2 Homo sapiensXR_001745172, XR_001745173ENSG00000233854
EL1080 pouBW1 N/A Gushi chickens and Anka broilersN/AN/A
EL1081 PPP3CB CALNA2; CALNB; CNA2; PP2Bbeta Homo sapiensN/AENSG00000107758
EL1082 PRAL N/A Homo sapiensN/AN/A
EL1083 PRAS N/A Homo sapiensN/AN/A
EL1084 Prep AI047692; AI450383; D10Wsu136e; PEP; Pop Mus musculusN/AENSMUSG00000019849
EL1085 PRINS NCRNA00074 Homo sapiensN/AENSG00000277563
EL1086 Prion-associated RNAs highly structured (shs)RNA Homo sapiensN/AN/A
EL1087 pRNA DDB_G0295593 Dictyostelium discoideum AX4N/AN/A
EL1088 PRNCR1 CARLo-3; PCAT8 Homo sapiensNR_109833ENSG00000282961
EL1089 PRR26 C10orf108 Homo sapiensNR_027151, NR_027152ENSG00000180525
EL1090 PRSS21 ESP-1; ESP1; TEST1; TESTISIN Homo sapiensNR_073012ENSG00000007038
EL1091 PsiLNCRNA00268512 N/A Populus sp.N/AN/A
EL1092 PSORS1C3 NCRNA00196 Homo sapiensNR_026816ENSG00000204528
EL1093 psvA antisense RNA EB4 gene locus Dictyostelium discoideum AX4N/AN/A
EL1094 PTCSC1 NCRNA00197; PTCSC Homo sapiensN/AN/A
EL1095 PTCSC2 N/A Homo sapiensN/AENSG00000236130
EL1096 PTCSC3 N/A Homo sapiensNR_049735ENSG00000259104
EL1097 PTENP1 PTEN-rs; PTEN2; PTENpg1; PTH2; psiPTEN Homo sapiensNR_023917ENSG00000237984
EL1098 PTENP1-AS PTENP1as; PTENpg1-asRNA Homo sapiensNR_103745ENSG00000281128
EL1099 Ptgs2os2 Gm26687; Linc-cox2; Lincrna-cox2 Mus musculusNR_110420ENSMUSG00000097754
EL1100 PTHLH BDE2; HHM; PLP; PTHR; PTHRP Homo sapiensN/AENSG00000087494
EL1101 PU.1 AS N/A Sus scrofaN/AN/A
EL1102 PVT1 LINC00079; MYC; NCRNA00079; onco-lncRNA-100 Homo sapiensNR_003367ENSG00000249859
EL1103 PWR1 PWR1 Saccharomyces cerevisiae S288cNR_132192N/A
EL1104 R05532 N/A Homo sapiensN/AN/A
EL1105 RAB4B-EGLN2 RERT-lncRNA Homo sapiensNR_037791N/A
EL1106 RAD1 HRAD1; REC1 Homo sapiensNR_026591ENSG00000113456
EL1107 RAD51-AS1 TODRA Homo sapiensNR_040058ENSG00000245849
EL1108 RBM4 LARKA; ZCCHC21; ZCRB3A; RBM4 Homo sapiensAF087999ENSG00000173933
EL1109 RBM5-AS1 LUST Homo sapiensNR_045388ENSG00000281691
EL1110 RCCRT1 N/A Homo sapiensN/AN/A
EL1111 RD29A N/A Arabidopsis thalianaAB428729N/A
EL1112 RepA N/A Mus musculusN/AN/A
EL1113 REST/CoREST-regulated lncRNAs N/A Homo sapiensN/AN/A
EL1114 RGMB-AS1 RGMB Antisense RNA Homo sapiensNR_033932ENSG00000246763
EL1115 RHOXF1P1 TCONS_00017086; lncRHOXF1 Homo sapiensNR_131250ENSG00000234493
EL1116 Rian 5530401N18Rik; C130089L09Rik; Meg8 Mus musculusNR_028261ENSMUSG00000097451
EL1117 Rmrp 1110032O22Rikr; Rmrp Mus musculusNR_001460ENSMUSG00000088088
EL1118 Rmst 100041799; AI853140; C230053E11Rik; D930049J19Rik; Dmt2; Gm3515; M2; Ncrms Mus musculusNR_028262N/A
EL1119 RMST LINC00054; NCRMS; NCRNA00054 Homo sapiensNR_024037ENSG00000255794
EL1120 RN7SK 7SK Homo sapiensNR_001445ENSG00000202198
EL1121 RN7SL1 7L1a; 7SL; RN7SL; RNSRP1 Homo sapiensNR_002715ENSG00000276168
EL1122 RNA polymerase III-dependent lncRNAs N/A Homo sapiensN/AN/A
EL1123 RNA44121|UCSC-2000-3182 N/A Homo sapiensN/AN/A
EL1124 RNA50010|UCSC-9199-1005 N/A Homo sapiensN/AN/A
EL1125 RNA58351|CombinedLit_316_550 N/A Homo sapiensN/AN/A
EL1126 RNA-a N/A Homo sapiensN/AN/A
EL1127 RNase MRP N/A Homo sapiensN/AN/A
EL1128 rncs-1 CELE_F55A4.9 Caenorhabditis elegansNR_000961N/A
EL1129 RNY1 HY1; Y1 Homo sapiensNR_004391ENSG00000201098
EL1130 roX1 Dmel_CR32777; BcDNA:GH10432; CR32777; DmelCR32777; EG:EG0002.2; RoX1; chrX:3706836..3706970; roX; rox1 Drosophila melanogasterNR_123784, NR_073631, NR_073632, NR_002097, NR_002098N/A
EL1131 roX2 Dmel_CR32665; CR32665; DmelCR32665; RoX2; roX; rox2 Drosophila melanogasterNR_002104, NR_002105, NR_047796, NR_047795, NR_123871, NR_123872N/A
EL1132 RP11-1008C21.2 N/A Homo sapiensN/AENST00000434223
EL1133 RP11-119F7.4 N/A Homo sapiensN/AN/A
EL1134 LOC102724601 RP11-160H22.5 Homo sapiensNR_121197ENSG00000227373
EL1135 LINC01537 RP11-169D4.1-001 Homo sapiensNR_126364ENSG00000227467
EL1136 LINC01513 RP11-1C1.7 Homo sapiensN/AENSG00000246016
EL1137 RP11-284N8.3.1 N/A Homo sapiensN/AN/A
EL1138 AL353732.1 RP11-354P17.15-001 Homo sapiensN/AENSG00000261696
EL1139 KCNMB2-AS1 RP11-385J1.2 Homo sapiensNR_126560ENSG00000237978
EL1140 AC027031.2 RP11-395G23.3 Homo sapiensN/AENSG00000254615
EL1141 RP11-395P13.3-001 N/A Homo sapiensN/AN/A
EL1142 LINC01627 RP11-397D12.4 Homo sapiensN/AENSG00000224648
EL1143 RP11-401P9.4 N/A Homo sapiensN/AENSG00000261685
EL1144 KCNK15-AS1 RP11-445H22.4 Homo sapiensNR_132377ENSG00000244558
EL1145 AL355870.1 RP11-445K13.2 Homo sapiensN/AENSG00000233256
EL1146 RP11-457M11.2 N/A Homo sapiensN/AN/A
EL1147 AC108134.4 RP11-473M20.11 Homo sapiensN/AENSG00000263011
EL1148 LINC00383 RP11-501G6.1 Homo sapiensN/AENSG00000237534
EL1149 AL138930.1 RP11-528G1.2 Homo sapiensN/AENSG00000234425
EL1150 ZBTB20-AS4 RP11-58D2.1 Homo sapiensNR_046877ENSG00000242767
EL1151 AC104590.1 RP11-643M14.1 Homo sapiensNR_135690ENSG00000259251
EL1152 AL133217.1 RP11-672F9.1 Homo sapiensN/AENSG00000226113
EL1153 RP11-766N7.3 N/A Homo sapiensN/AN/A
EL1154 LINC01612 RP11-789C1.1 Homo sapiensN/AENSG00000250266
EL1155 Z95152.1 RP1-179N16.3 Homo sapiensN/AENSG00000237719
EL1156 LINC01969 RP11-893F2.6 Homo sapiensNR_110806ENSG00000251085
EL1157 AL020996.1 RP1-317E23.3 Homo sapiensN/AENSG00000228172
EL1158 RP13-514E23.1 N/A Homo sapiensN/AENSG00000261496
EL1159 RP1-90D4.3 N/A Homo sapiensN/AN/A
EL1160 AL021707.1 RP3-508I15.14 Homo sapiensN/AENSG00000225450
EL1161 AL109741.3 RP4-575N6.5 Homo sapiensN/AENSG00000260940
EL1162 AL121845.1 RP4-583P15.10 Homo sapiensN/AENSG00000229299
EL1163 RP4-620F22.3 N/A Homo sapiensN/AN/A
EL1164 AC244098.1 RP5-1014O16.1 Homo sapiensN/AENSG00000223377
EL1165 AL445307.1 RP5-826L7.1 Homo sapiensN/AENSG00000228692
EL1166 RP5-833A20.1 N/A Homo sapiensN/AN/A
EL1167 RP5-843L14.1 N/A Homo sapiensN/AN/A
EL1168 RPL34-AS1 RP11-462C24.1; FLJ37673; RPL34-AS1 Homo sapiensNR_026968ENSG00000234492
EL1169 RPLP0P2 RPLP0L2; RPLP0_3_1146 Homo sapiensNR_002775ENSG00000243742
EL1170 Rr18 Xca; Xce; Xite Mus musculusN/AN/A
EL1171 RRP1B KIAA0179; NNP1L; Nnp1; PPP1R136; RRP1 Homo sapiensN/AENSG00000160208
EL1172 Rubie N/A Mus musculusNR_046459ENSMUSG00000085123
EL1173 RUNX1 AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2; EVI-1; PEBP2aB; PEBP2alpha Homo sapiensN/AENSG00000159216
EL1174 RUNX1-IT1 C21orf96 Homo sapiensNR_026812N/A
EL1175 RZE1 N/A Cryptococcus neoformansN/AN/A
EL1176 SALRNA1 SAL-RNA1; XLOC_023166 Homo sapiensNR_126480N/A
EL1177 SAMMSON LINC01212 Homo sapiensNR_110000ENSG00000240405
EL1178 SARCC N/A Homo sapiensN/AN/A
EL1179 Scarb2 9330185J12Rik; Cd36l2; LGP85; LIMP II; LIMP-2; MLGP85 Mus musculusAK036863.1ENSMUSG00000029426
EL1180 SCHLAP1 LINC00913; PCAT11; PCAT114 Homo sapiensNR_104322, NR_104325, NR_104324, NR_104323, NR_104319, NR_104320, NR_104321ENSG00000281131
EL1181 Sema3g AK129018 Mus musculusAK087277.1ENSMUSG00000021904
EL1182 SENCR FLI1-AS1; lncRNA9 Homo sapiensNR_038908ENSG00000254703
EL1183 sfRNA N/A Japanese encephalitis virusEF116943.1N/A
EL1184 SFTA3 NANCI; SFTPH; SP-H Homo sapiensNR_138595, NR_138596, NR_138597, NR_138598, NR_138599, NR_138600, NR_138601ENSG00000229415
EL1185 SGO1-AS1 SGOL1-AS1 Homo sapiensNR_132785ENSG00000231304
EL1186 Sho N/A Petunia hybridaAF346892N/A
EL1187 Si lincRNA113 N/A Setaria italicaN/AN/A
EL1188 Si lincRNA121 N/A Setaria italicaN/AN/A
EL1189 Si lincRNA150 N/A Setaria italicaN/AN/A
EL1190 Si lincRNA18 N/A Setaria italicaN/AN/A
EL1191 Si lincRNA180 N/A Setaria italicaN/AN/A
EL1192 Si lincRNA212 N/A Setaria italicaN/AN/A
EL1193 Si lincRNA248 N/A Setaria italicaN/AN/A
EL1194 Si lincRNA288 N/A Setaria italicaN/AN/A
EL1195 Si lincRNA32 N/A Setaria italicaN/AN/A
EL1196 Si lincRNA373 N/A Setaria italicaN/AN/A
EL1197 Si lincRNA396 N/A Setaria italicaN/AN/A
EL1198 Si lincRNA403 N/A Setaria italicaN/AN/A
EL1199 Si lincRNA416 N/A Setaria italicaN/AN/A
EL1200 Si lincRNA438 N/A Setaria italicaN/AN/A
EL1201 Si lincRNA446 N/A Setaria italicaN/AN/A
EL1202 Si lincRNA489 N/A Setaria italicaN/AN/A
EL1203 Si lincRNA69 N/A Setaria italicaN/AN/A
EL1204 Si NAT52 N/A Setaria italicaN/AN/A
EL1205 Si NAT80 N/A Setaria italicaN/AN/A
EL1206 SIRT1-AS N/A Homo sapiensN/AN/A
EL1207 SIRT1-AS 622C mutation N/A Homo sapiensN/AN/A
EL1208 Six3os1 D17Mgi26; E130112H22Rik; Rncr1; Six3os Mus musculusNR_038085, NR_015387, NR_015386, NR_038086, NR_038083, NR_038082, NR_038084, NR_015385ENSMUSG00000093460
EL1209 SKP2 FBL1; FBXL1; FLB1; p45 Homo sapiensXR_001742203ENSG00000145604
EL1210 SLC25A25-AS1 N/A Homo sapiensNR_033374N/A
EL1211 Slc44a1 2210409B22Rik; 4833416H08Rik; AW547365; CHTL1; CTL1; Cdw92 Mus musculusXR_390309ENSMUSG00000028412
EL1212 SLC6A6 TAUT Homo sapiensNR_103507, XR_427286, XR_940495ENSG00000131389
EL1213 SLC7A2-IT1A/B N/A Homo sapiensN/AN/A
EL1214 SLCO5A1 OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4; SLC21A15 Homo sapiensXR_928814, XR_428341ENSG00000137571
EL1215 SMAD1-AS1 N/A Homo sapiensNR_126371ENSG00000250902
EL1216 Smad7 Madh7 Mus musculusN/AENSMUSG00000025880
EL1217 sme2 SPNCRNA.103; SPNCRNA.1341 Schizosaccharomyces pombe 972h-N/AN/A
EL1218 SNAR-A1 SNAR-A53113498 Homo sapiensNR_004435N/A
EL1219 SNCG BCSG1; SR Homo sapiensN/AENSG00000173267
EL1220 SNED1 SST3; Snep Homo sapiensXR_001738694, XR_001738695ENSG00000162804
EL1221 SNHG1 LINC00057; NCRNA00057; U22HG; UHG Homo sapiensNR_003098ENSG00000255717
EL1222 SNHG11 C20orf198; LINC00101; NCRNA00101 Homo sapiensNR_003239ENSG00000174365
EL1223 SNHG12 ASLNC04080; C1orf79; LINC00100; NCRNA00100 Homo sapiensNR_024127ENSG00000197989
EL1224 SNHG14 115HG; LNCAT; NCRNA00214; UBE3A-AS; UBE3A-AS1; UBE3AATS Homo sapiensN/AN/A
EL1225 SNHG15 C7orf40; Linc-Myo1g; MYO1GUT Homo sapiensNR_003697ENSG00000232956
EL1226 SNHG16 ncRAN Homo sapiensNR_038108, NR_038109, NR_038110, NR_038111ENSG00000163597
EL1227 SNHG19 SNORD60HG Homo sapiensNR_132114ENSG00000260260
EL1228 SNHG3 NCRNA00014; RNU17C; RNU17D; U17HG; U17HG-A; U17HG-AB Homo sapiensNR_036473, NR_002909ENSG00000242125
EL1229 Snhg3 Rnu17d; U17HG Mus musculusNR_003270ENSMUSG00000085241
EL1230 SNHG4 NCRNA00059; U19H Homo sapiensNR_036536, NR_003141N/A
EL1231 SNHG5 C6orf160; LINC00044; NCRNA00044; U50HG; bA33E24.2 Homo sapiensNR_003038ENSG00000203875
EL1232 SNHG6 HBII-276HG; NCRNA00058; U87HG Homo sapiensNR_002599N/A
EL1233 SNHG8 LINC00060; NCRNA00060 Homo sapiensNR_003584, NR_034010, NR_034011ENSG00000269893
EL1234 SNORA17B ACA43; SNORA43 Homo sapiensNR_002975ENSG00000276161
EL1235 Sox2ot B230215L15Rik Mus musculusNR_015580ENSMUSG00000105265
EL1236 SOX2-OT NCRNA00043; SOX2OT Homo sapiensNR_075091, NR_075092, NR_075093, NR_004053, NR_075089, NR_075090ENSG00000242808
EL1237 SOX2OT-S1 N/A Homo sapiensN/AN/A
EL1238 SOX2OT-S2 N/A Homo sapiensN/AN/A
EL1239 Sox4 AA682046; Sox-4 Mus musculusAK054386.1ENSMUSG00000076431
EL1240 SPRY4-IT1 SPRIGHTLY Homo sapiensNR_131221ENSG00000281881
EL1241 SRA1 SRA; SRAP; STRAA1; pp7684 Homo sapiensNR_045586, NR_045587ENSG00000213523
EL1242 SrENOD40-1 N/A Sesbania rostrataY12714N/A
EL1243 SRG1 SRG1 Saccharomyces cerevisiae S288cNR_132168N/A
EL1244 SRP RNA 7S RNA; SRP RNA; 4.5S SRP RNA; 4.5S RNA; RN7SL1 RNA; ENSG00000258486 Archaeoglobus fulgidus, Methanococcus jannaschiiN/AN/A
EL1245 Srsf9 25kDa; 2610029M16Rik; SRp30c; Sfrs9 Mus musculusNR_036616ENSMUSG00000029538
EL1246 ST7-AS1 ST7AS1; ST7OT1 Homo sapiensNR_002330ENSG00000227199
EL1247 ST7-AS2 ST7AS2; ST7OT2 Homo sapiensNR_109980, NR_109981, NR_002331ENSG00000226367
EL1248 ST7-OT3 NCRNA00026; ST7; ST7OT3 Homo sapiensNR_002332N/A
EL1249 ST7-OT4 NCRNA00042; ST7OT4 Homo sapiensNR_002329ENSG00000214188
EL1250 SUMO1P3 Small ubiquitin-like modifier (SUMO) 1 pseudogene 3 Homo sapiensNR_002190ENSG00000235082
EL1251 TalIPS1 N/A Triticum aestivumBQ744479N/A
EL1252 TalncRNA106 N/A Triticum aestivumKC549677N/A
EL1253 TalncRNA108 N/A Triticum aestivumKC549678N/A
EL1254 TalncRNA18 N/A Triticum aestivumKC549675N/A
EL1255 TalncRNA73 N/A Triticum aestivumKC549676N/A
EL1256 TapmlnRNA19 N/A Triticum aestivumN/AN/A
EL1257 TapmlnRNA27 N/A Triticum aestivumN/AN/A
EL1258 TapmlnRNA30 N/A Triticum aestivumN/AN/A
EL1259 TapmlnRNA5 N/A Triticum aestivumN/AN/A
EL1260 TapmlnRNA9 N/A Triticum aestivumN/AN/A
EL1261 TAR-191 N/A Arabidopsis thalianaN/AN/A
EL1262 TAR-224 N/A Arabidopsis thalianaN/AN/A
EL1263 TARID EYA4-AS1 Homo sapiensNR_109982ENSG00000227954
EL1264 TaS1 N/A Triticum aestivumBQ168479N/A
EL1265 TaS2 N/A Triticum aestivumCA648596N/A
EL1266 TC0100223 N/A Homo sapiensN/AN/A
EL1267 TC0101441 N/A Homo sapiensN/AN/A
EL1268 TC0101686 N/A Homo sapiensN/AN/A
EL1269 TC1500845 N/A Homo sapiensN/AN/A
EL1270 TCF7 TCF-1 Homo sapiensNR_033449ENSG00000081059
EL1271 TCL6 TNG1; TNG2 Homo sapiensNR_028288ENSG00000187621
EL1272 TCONS_00000649 N/A Zea maysKJ731892N/A
EL1273 TCONS_00000966 N/A Brassica napusN/AN/A
EL1274 TCONS_00007700 N/A Zea maysKJ731849N/A
EL1275 TCONS_00010027 N/A Zea maysN/AN/A
EL1276 TCONS_00012273 N/A Populus tomentosaN/AN/A
EL1277 TCONS_00012662 N/A Zea maysKJ731890N/A
EL1278 TCONS_00012690 N/A Zea maysKJ731898N/A
EL1279 TCONS_00012703 N/A Zea maysKJ731903N/A
EL1280 TCONS_00012768 N/A Zea maysKJ731916N/A
EL1281 TCONS_00014512 N/A Homo sapiensN/AN/A
EL1282 AC069120.3 TCONS_00014978; RP11-675F6.4-001 Homo sapiensN/AENSG00000254100
EL1283 TCONS_00018278 N/A Homo sapiensN/AN/A
EL1284 TCONS_00022311 N/A Populus tomentosaN/AN/A
EL1285 TCONS_00023843 N/A Populus tomentosaN/AN/A
EL1286 TCONS_00024309 N/A Zea maysKJ731978N/A
EL1287 TCONS_00024310 N/A Zea maysKJ731979N/A
EL1288 TCONS_00024647 N/A Homo sapiensN/AN/A
EL1289 TCONS_00026506 N/A Homo sapiensN/AN/A
EL1290 TCONS_00026694 N/A Populus tomentosaN/AN/A
EL1291 TCONS_00028236 N/A Populus tomentosaN/AN/A
EL1292 TCONS_00032782 N/A Populus tomentosaN/AN/A
EL1293 TCONS_00037470 N/A Zea maysKJ732037N/A
EL1294 TCONS_00039944 N/A Populus tomentosaN/AN/A
EL1295 TCONS_00042984 N/A Zea maysKJ732080N/A
EL1296 TCONS_00044116 N/A Zea maysKJ732097N/A
EL1297 TCONS_00044376 N/A Populus tomentosaN/AN/A
EL1298 TCONS_00048079 N/A Populus tomentosaN/AN/A
EL1299 TCONS_00049512 N/A Populus tomentosaN/AN/A
EL1300 TCONS_00053930 N/A Populus tomentosaN/AN/A
EL1301 TCONS_00054544 N/A Zea maysKJ731879N/A
EL1302 TCONS_00055243 N/A Populus tomentosaN/AN/A
EL1303 TCONS_00056386 N/A Populus tomentosaN/AN/A
EL1304 TCONS_00056395 N/A Zea maysKJ732143N/A
EL1305 TCONS_00060049 N/A Populus tomentosaN/AN/A
EL1306 TCONS_00061773 N/A Populus tomentosaN/AN/A
EL1307 TCONS_00082174 N/A Zea maysKJ732289N/A
EL1308 TCONS_00089485 N/A Zea maysN/AN/A
EL1309 TCONS_00090092_MEG3 N/A Homo sapiensN/AN/A
EL1310 TCONS_l2_00000179 N/A Homo sapiensN/AN/A
EL1311 TCONS_l2_00003938 N/A Homo sapiensN/AN/A
EL1312 TCONS_l2_00004424 N/A Homo sapiensN/AN/A
EL1313 TCONS_l2_00006843 N/A Homo sapiensN/AN/A
EL1314 TCONS_l2_00010365 N/A Homo sapiensN/AN/A
EL1315 TCONS_l2_00014091 N/A Homo sapiensN/AN/A
EL1316 TCONS_l2_00018070 N/A Homo sapiensN/AN/A
EL1317 TCONS_l2_00018071 N/A Homo sapiensN/AN/A
EL1318 TCONS_l2_00020565 N/A Homo sapiensN/AN/A
EL1319 TCONS_l2_00021262 N/A Homo sapiensN/AN/A
EL1320 TCONS_l2_00030560 N/A Homo sapiensN/AN/A
EL1321 TDRG1 LINC00532 Homo sapiensNR_024015ENSG00000204091
EL1322 TER N/A Arabidopsis thalianaN/AN/A
EL1323 TER1 N/A Arabidopsis thalianaN/AN/A
EL1324 TER2 N/A Arabidopsis thalianaN/AN/A
EL1325 TERC DKCA1; PFBMFT2; SCARNA19; TR; TRC3; hTR Homo sapiensNR_001566ENSG00000270141
EL1326 TGFB2-OT1 N/A Homo sapiensNR_125715ENSG00000281453
EL1327 TH2LCRR TH2-LCR Homo sapiensNR_132124, NR_132125, NR_132126ENSG00000223442
EL1328 THRIL BRI3BP-AS1; BRI3BPAS1; Linc1992; TCONS_00020260 Homo sapiensNR_110375ENSG00000280634
EL1329 TI09485 N/A Homo sapiensN/AN/A
EL1330 TI10124 N/A Homo sapiensN/AN/A
EL1331 TI13831 N/A Homo sapiensN/AN/A
EL1332 TI18318 N/A Homo sapiensN/AN/A
EL1333 TI21327 N/A Homo sapiensN/AN/A
EL1334 TI22687 N/A Homo sapiensN/AN/A
EL1335 tie-1as N/A Danio rerioNR_036574N/A
EL1336 TINCR LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 Homo sapiensNR_027064ENSG00000223573
EL1337 TIP ncRNA N/A Mus musculusN/AN/A
EL1338 TK105282 N/A Mus musculusN/AN/A
EL1339 TK111271 N/A Mus musculusN/AN/A
EL1340 TK99129 N/A Mus musculusN/AN/A
EL1341 Tmcc3 AW488095; C630016B22Rik; C88213; Tmcc1 Mus musculusN/AENSMUSG00000020023
EL1342 TMEM179 C14orf90A; TMEM179 Homo sapiensXR_943436, XR_943435, XR_943433ENSG00000258986
EL1343 TMEM72 C10orf127; KSP37 Homo sapiensN/AENSG00000187783
EL1344 Tmevp3 NeST Mus musculusN/AN/A
EL1345 Tmevpg1 AI447422 Mus musculusNR_104123N/A
EL1346 TMPOP2 lncRNA-EBIC Homo sapiensN/AENSG00000262904
EL1347 TNXA D6S103E; HXBL; TNX; XA Homo sapiensNR_001284ENSG00000248290
EL1348 Tog Twin of Hotdog Mus musculus, Atelerix albiventrisBK008788N/A
EL1349 TP53COR1 TRP53COR1; linc-p21; lincRNA-p21 Homo sapiensCD515754.1N/A
EL1350 TP53TG1 LINC00096; NCRNA00096; P53TG1; P53TG1-D; TP53AP1 Homo sapiensNR_015381ENSG00000182165
EL1351 TP73-AS1 KIAA0495; PDAM Homo sapiensNR_033709, NR_033710, NR_033711, NR_033708, NR_033712ENSG00000227372
EL1352 TPS1 SlTPS1 Solanum lycopersicumN/AN/A
EL1353 TPS11 N/A Solanum lycopersicumN/AN/A
EL1354 TPSI1 N/A Solanum lycopersicumNR_131747N/A
EL1355 TRAF3IP2-AS1 C6UAS; C6orf3; NCRNA00248; TRAF3IP2-AS2 Homo sapiensNR_034108, NR_034109, NR_034110, NR_034111ENSG00000231889
EL1356 TRE1 N/A Mus musculusN/AN/A
EL1357 TRE2 N/A Mus musculusN/AN/A
EL1358 TRE3 N/A Mus musculusN/AN/A
EL1359 Trenod40 N/A Trifolium repensAJ000268N/A
EL1360 Trenod40-1 N/A Trifolium repensAF426838N/A
EL1361 Trenod40-2 N/A Trifolium repensAF426839N/A
EL1362 Trenod40-3 N/A Trifolium repensAF426840N/A
EL1363 TRERNA1 LINC00651; treRNA Homo sapiensNR_051976ENSG00000231265
EL1364 TRIM52-AS1 RIM52 Antisense RNA 1 Homo sapiensNR_102762, NR_102759, NR_102760, NR_102761ENSG00000248275
EL1365 Trp53cor1 Gm16197; OTTMUSG00000031656; linc-p21; lincRNA-p21 Mus musculusNR_036469ENSMUSG00000085912
EL1366 TRPM2-AS TRPM2-AS1 Homo sapiensNR_109964ENSG00000230061
EL1367 Trpm3 6330504P12Rik; 9330180E14; AU018608; B930001P07Rik; LTRPC3; MLSN2 Mus musculusXR_386462, XR_386463ENSMUSG00000052387
EL1368 TSIX LINC00013; NCRNA00013; XIST-AS; XIST-AS1; XISTAS Homo sapiensNR_003255ENSG00000270641
EL1369 Tsix N/A Mus musculusNR_002844ENSMUSG00000085715
EL1370 TSNAX-DISC1 N/A Homo sapiensNR_028393, NR_028394, NR_028395, NR_028397, NR_028396, NR_028398, NR_028400, NR_028399ENSG00000270106
EL1371 TSPAN8 CO-029; TM4SF3 Homo sapiensN/AENSG00000127324
EL1372 Ttc39aos1 Gm12750; lincRNA-EPS Mus musculusNR_131195N/A
EL1373 tts-1 CELE_F09E10.11 Caenorhabditis elegansNR_001528, NR_001529N/A
EL1374 TU1273 N/A Ganoderma lucidumN/AN/A
EL1375 TU1378 N/A Ganoderma lucidumN/AN/A
EL1376 TU1403 N/A Ganoderma lucidumN/AN/A
EL1377 TU1555 N/A Ganoderma lucidumN/AN/A
EL1378 TU1567 N/A Ganoderma lucidumN/AN/A
EL1379 TU1970 N/A Ganoderma lucidumN/AN/A
EL1380 TU3327 N/A Ganoderma lucidumN/AN/A
EL1381 TU3423 N/A Ganoderma lucidumN/AN/A
EL1382 TU4313 N/A Ganoderma lucidumN/AN/A
EL1383 TU4314 N/A Ganoderma lucidumN/AN/A
EL1384 TU4508 N/A Ganoderma lucidumN/AN/A
EL1385 TU4652 N/A Ganoderma lucidumN/AN/A
EL1386 TU4684 N/A Ganoderma lucidumN/AN/A
EL1387 TU4779 N/A Ganoderma lucidumN/AN/A
EL1388 TU5007 N/A Ganoderma lucidumN/AN/A
EL1389 TU506 N/A Ganoderma lucidumN/AN/A
EL1390 TU51 N/A Ganoderma lucidumN/AN/A
EL1391 TU5846 N/A Ganoderma lucidumN/AN/A
EL1392 TU6607 N/A Ganoderma lucidumN/AN/A
EL1393 TU6608 N/A Ganoderma lucidumN/AN/A
EL1394 TU718 N/A Ganoderma lucidumN/AN/A
EL1395 TU781 N/A Ganoderma lucidumN/AN/A
EL1396 TUBA4B TUBA4 Homo sapiensNR_003063ENSG00000243910
EL1397 TUC339 N/A Homo sapiensN/AN/A
EL1398 T-UCRs N/A Homo sapiensN/AN/A
EL1399 TUG1 LINC00080; NCRNA00080; TI-227H Homo sapiensNR_110492, NR_002323, NR_110493ENSG00000253352
EL1400 Tug1 AI316828 Mus musculusNR_002321, NR_110490, NR_002322ENSMUSG00000056579
EL1401 TUNAR HI-LNC78; LINC00617; TUNA Homo sapiensNR_132399, NR_132398, NR_038861ENSG00000250366
EL1402 TUSC7 LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 Homo sapiensNR_015391ENSG00000243197
EL1403 TUSC8 LINC01071; XLOC_010588 Homo sapiensNR_104174ENSG00000237361
EL1404 U1 spliceosomal lncRNA N/A Homo sapiensN/AN/A
EL1405 Ube3a-ATS N/A Homo sapiensN/AN/A
EL1406 uc.115- N/A Mus musculusN/AN/A
EL1407 uc.173 N/A Mus musculusN/AN/A
EL1408 uc.184+ N/A Mus musculusN/AN/A
EL1409 uc.283-plus N/A Homo sapiensN/AN/A
EL1410 uc.341 N/A Homo sapiensN/AN/A
EL1411 uc.388 N/A Homo sapiensN/AN/A
EL1412 uc.73 N/A Homo sapiensN/AN/A
EL1413 uc001aka.2 N/A Homo sapiensN/AN/A
EL1414 uc001gch.1 N/A Homo sapiensN/AN/A
EL1415 uc001gzl.3 N/A Homo sapiensN/AN/A
EL1416 uc001lsz N/A Homo sapiensN/AN/A
EL1417 uc001ncr N/A Homo sapiensN/AN/A
EL1418 LOC100288208 uc001vjj.1 Homo sapiensNR_144452ENSG00000177596
EL1419 uc002nbr.3 N/A Homo sapiensN/AN/A
EL1420 LINC01589 uc003bgl.1; TCONS_00029353 Homo sapiensNR_131244ENSG00000238120
EL1421 uc003erl.1 N/A Homo sapiensN/AN/A
EL1422 uc003iqu LINC01207 Homo sapiensNR_038834ENSG00000248771
EL1423 uc003jfz.2 ASHG19A3A028003; uc003jfz.2 Homo sapiensN/AN/A
EL1424 uc003tfx N/A Homo sapiensN/AN/A
EL1425 AC091173.1 uc003xut. Homo sapiensN/AENSG00000251127
EL1426 uc004bbl.1 N/A Homo sapiensN/AN/A
EL1427 uc004bdv.3 N/A Homo sapiensN/AN/A
EL1428 uc009wkz.1 N/A Homo sapiensN/AN/A
EL1429 uc021re1.1 N/A Homo sapiensN/AN/A
EL1430 uc022axw.1 N/A Homo sapiensN/AN/A
EL1431 UCA1 CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 Homo sapiensNR_015379ENSG00000214049
EL1432 UCA1 N/A Rattus norvegicusN/AN/A
EL1433 UCH1LAS UCH1LAS; RP11-124A7.2 Homo sapiensN/AN/A
EL1434 UCHL1-AS1 N/A Homo sapiensNR_102709ENSG00000251173
EL1435 UFC1 HSPC155 Homo sapiensN/AENSG00000143222
EL1436 Uhg1 Dmel_CR32886; BEST:GM03135; CG14486; CR32886; DmelCR32886; Dros-UHG1; FBgn0040741; dUHG1; dUhg1 Drosophila melanogasterNR_001754, NR_073887N/A
EL1437 Uhg2 Dmel_CR32873; CR32873; DmelCR32873; Dros-UHG2; dUHG2; dUhg2 Drosophila melanogasterNR_001637, NR_073751N/A
EL1438 ULK4P2 D-X; FAM7A2 Homo sapiensNR_027470ENSG00000260128
EL1439 URHC N/A Homo sapiensN/AN/A
EL1440 VAI VA RNA I;VA RNA II. Human adenovirusN/AN/A
EL1441 VAII N/A Human adenovirusN/AN/A
EL1442 Vax2os Vas2os1; Vax2os2; Vax2os Mus musculusNR_002871, NR_002873, NR_075094, NR_075095ENSMUSG00000085794
EL1443 VIM2P VIM2; VIMP1; lncRNA-CIR Homo sapiensN/AENSG00000220548
EL1444 VL30 LTRs N/A Mus musculusN/AN/A
EL1445 VL30 RNAs N/A Mus musculusN/AN/A
EL1446 VLDLR-AS1 linc-VLDLR; lincRNA-VLDLR Homo sapiensNR_015375ENSG00000236404
EL1447 VNN2 FOAP-4; GPI-80 Homo sapiensNR_110146, NR_034174, NR_034173, NR_110144, NR_110143, NR_110145ENSG00000112303
EL1448 VPS9D1-AS1 MYU Homo sapiensNR_036480ENSG00000261373
EL1449 VsENOD40 N/A Vicia sativaX83683N/A
EL1450 VTRNA2-1 CBL-3; CBL3; MIR886; MIRN886; VTRNA2; hsa-mir-886; hvg-5; nc886; svtRNA2-1a Homo sapiensNR_030583ENSG00000270123
EL1451 Wbp1l Opal1; RGD1305793 Rattus norvegicusN/AENSRNOG00000020020
EL1452 WFDC21P LNCDC; linc-DC; lnc-DC Homo sapiensNR_030732ENSG00000261040
EL1453 WISP1 CCN4c; WISP1i; WISP1tc; WISP1 Homo sapiensNR_037944ENSG00000104415
EL1454 WRAP53 DKCB3; TCAB1; WDR79 Homo sapiensXR_001752551ENSG00000141499
EL1455 WSPAR LncTCF7; TCONS_00009511 Homo sapiensNR_131252ENSG00000249073
EL1456 WT1-AS WIT-1; WIT11; WT1AS; WT1-AS Homo sapiensNR_120548, NR_120547, NR_023920, NR_120549, NR_120546ENSG00000183242
EL1457 Wt1os 6030498F17; AI314831; Wt1-as Mus musculusNR_015462ENSMUSG00000074987
EL1458 XACT N/A Homo sapiensNR_131204ENSG00000241743
EL1459 XIST DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 Homo sapiensNR_001564ENSG00000229807
EL1460 Xist A430022B11; AI314753 Mus musculusNR_001570, NR_001463ENSMUSG00000086503
EL1461 XLOC_000078 N/A Oryza sativaN/AN/A
EL1462 XLOC_000371 N/A Homo sapiensN/AN/A
EL1463 XLOC_000495 N/A Oryza sativaN/AN/A
EL1464 XLOC_000620 N/A Homo sapiensN/AN/A
EL1465 XLOC_000629 N/A Oryza sativaN/AN/A
EL1466 XLOC_000775 N/A Oryza sativaN/AN/A
EL1467 XLOC_000829 N/A Oryza sativaN/AN/A
EL1468 XLOC_000869 N/A Oryza sativaN/AN/A
EL1469 XLOC_000909 N/A Oryza sativaN/AN/A
EL1470 XLOC_000999 N/A Oryza sativaN/AN/A
EL1471 XLOC_001095 N/A Oryza sativaN/AN/A
EL1472 XLOC_001234 N/A Oryza sativaN/AN/A
EL1473 XLOC_001235 N/A Oryza sativaN/AN/A
EL1474 XLOC_003286 N/A Homo sapiensN/AN/A
EL1475 XLOC_003405 N/A Homo sapiensN/AN/A
EL1476 XLOC_004026 N/A Oryza sativaN/AN/A
EL1477 XLOC_004031 N/A Oryza sativaN/AN/A
EL1478 XLOC_004122 N/A Homo sapiensN/AN/A
EL1479 XLOC_004186 N/A Oryza sativaN/AN/A
EL1480 XLOC_004275 N/A Oryza sativaN/AN/A
EL1481 XLOC_004478 N/A Oryza sativaN/AN/A
EL1482 XLOC_004507 N/A Oryza sativaN/AN/A
EL1483 XLOC_004531 N/A Oryza sativaN/AN/A
EL1484 XLOC_004562 N/A Homo sapiensN/AN/A
EL1485 XLOC_004689 N/A Oryza sativaN/AN/A
EL1486 XLOC_004714 N/A Oryza sativaN/AN/A
EL1487 XLOC_004798 N/A Oryza sativaN/AN/A
EL1488 XLOC_004876 N/A Oryza sativaN/AN/A
EL1489 XLOC_004881 N/A Oryza sativaN/AN/A
EL1490 XLOC_004932 N/A Oryza sativaN/AN/A
EL1491 XLOC_004933 N/A Oryza sativaN/AN/A
EL1492 XLOC_004944 N/A Oryza sativaN/AN/A
EL1493 XLOC_005031 N/A Oryza sativaN/AN/A
EL1494 XLOC_005912 N/A Homo sapiensN/AN/A
EL1495 XLOC_007072 N/A Oryza sativaN/AN/A
EL1496 XLOC_007697 XLOC_007697; LOC105500239 Homo sapiensNR_131213N/A
EL1497 XLOC_008559 XLOC_008559; LOC105378427 Homo sapiensNR_131214N/A
EL1498 XLOC_009232 N/A Oryza sativaN/AN/A
EL1499 XLOC_009911 XLOC_009911; LOC105500240 Homo sapiensNR_131215N/A
EL1500 XLOC_010235 N/A Homo sapiensN/AN/A
EL1501 XLOC_012255 N/A Homo sapiensN/AN/A
EL1502 XLOC_014172 N/A Homo sapiensN/AN/A
EL1503 XLOC_014388 N/A Homo sapiensN/AN/A
EL1504 XLOC_016182 N/A Oryza sativaN/AN/A
EL1505 XLOC_018316 N/A Oryza sativaN/AN/A
EL1506 XLOC_037529 N/A Oryza sativaN/AN/A
EL1507 XLOC_040350 N/A Oryza sativaN/AN/A
EL1508 XLOC_057324 N/A Oryza sativaN/AN/A
EL1509 XLOC_057981 N/A Oryza sativaN/AN/A
EL1510 Xlsirts N/A Xenopus laevisN/AN/A
EL1511 XR_250621.1 N/A Homo sapiensN/AN/A
EL1512 XRN1 YGL173C; DST2; KEM1; RAR5; SEP1; SKI1 Saccharomyces cerevisiae S288cN/AN/A
EL1513 Yam-1 N/A Mus musculusN/AN/A
EL1514 LOC105373051 Z82214.3 Homo sapiensNR_134632ENSG00000236272
EL1515 ZEB1-AS1 N/A Homo sapiensNR_024284N/A
EL1516 ZEB2-AS1 ZEB2-AS; ZEB2AS; ZEB2NAT Homo sapiensNR_040248ENSG00000238057
EL1517 ZFAS1 C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 Homo sapiensNR_003604, NR_036658, NR_003606, NR_003605, NR_036659ENSG00000177410
EL1518 ZFAT-AS1 NCRNA00070; SAS-ZFAT; ZFAT-AS; ZFATAS Homo sapiensNR_002438ENSG00000248492
EL1519 Zfhx2os Zfhx2as Mus musculusNR_004444ENSMUSG00000093452
EL1520 Zim3 1700128I23Rik Mus musculusNR_036631ENSMUSG00000108043
EL1521 Zm401 N/A Nicotiana tabacumN/AN/A
EL1522 Zm401 N/A Zea maysAY800268N/A
EL1523 Zm401p10 N/A Zea maysAY911609N/A
EL1524 ZMAT1 ZMAT1; KIAA1789 Homo sapiensN/AENSG00000166432
EL1525 ZmIPS1 N/A Zea maysBM379264N/A
EL1526 ZNF295-AS1 C21orf121; NCRNA00318; PRED87 Homo sapiensNR_119384, NR_119385, NR_027273ENSG00000237232
EL1527 ZNF350-AS1 HCCAT3; uc002pyc Homo sapiensNR_103847ENSG00000269235
EL1528 ZNF667-AS1 MORT Homo sapiensNR_036521, NR_036522ENSG00000166770
EL1529 ZNF674-AS1 NR_015378; ZNF674-AS1 Homo sapiensNR_015378ENSG00000230844
EL1530 ZPR4 AT2G36307; LITTLE ZIPPER 4 Arabidopsis thalianaNR_143764N/A
EL1533 apela ELABELA, ela, si:ch211-42i9.4, tdl Danio rerioNM_001297547ENSDARG00000094729
EL1536 MRLN LINC00948, Linc-RAM, M1, MLN, MUSER1 Homo sapiensNM_001304731, NM_001304732ENSG00000227877
EL1535 DWORF N/A Homo sapiensNR_037902ENSG00000240045
EL1532 APELA ELA, Ende, tdl Homo sapiensNM_001297550, XM_017007623ENSG00000248329
EL1537 Mrln 2310015B20Rik, Mln Mus musculusNM_001304739, XM_017314076ENSMUSG00000019933
EL1531 Apela Ela, Ende, Gm10664 Mus musculusNM_001297554, XM_011242247ENSMUSG00000079042
EL1534 Gm34302 N/A Mus musculusXR_375707, XR_375708ENSMUSG00000103476
EL0388 ENOD40-1 N/A Glycine maxX69154N/A
EL1538 SclA Dmel_CG45090, BEST:LP06756, BcDNA:RE28911, CG45090, CR31696, DmelCG45090, ORF-A, mel1, pncr003, pncr003:2L, pncr003:2L ORFA, pncr:003:2L, scl, sclA Drosophila melanogasterNM_001299066, NM_001299065, NM_001299067N/A
EL1539 SclB Dmel_CG45091, BEST:LP06756, BcDNA:RE28911, CG45091, CR31696, DmelCG45091, ORF-B, mel2, pncr003, pncr003:2L, pncr003:2L ORFB, pncr:003:2L, scl Drosophila melanogasterNM_001299063, NM_001299062, NM_001299064, NM_001299061N/A
EL1540 tal-1A Dmel_CG42384, CG42384, Dm1, DmelCG42384, ORF 1A, ORF1, Pep1, Tal1A, pri, tal Drosophila melanogasterNM_001144578N/A
EL1541 tal-2A Dmel_CG42385, CG42385, Dm2, DmelCG42385, ORF 2A, ORF2, Pep2, pri, tal Drosophila melanogasterNM_001144579N/A
EL1542 tal-3A Dmel_CG42386, CG42386, Dm3, DmelCG42386, ORF 3A, ORF3, Pep3, pri, tal Drosophila melanogasterNM_001144580N/A
EL1543 tal-AA Dmel_CG42387, CG42387, Dm4, Dm_3R:52381, DmelCG42387, ORF AA, ORF4, Pep4, pri, tal Drosophila melanogasterNM_001144577N/A
DISEASES
ID lncRNA
Name
Disease Method Sample Expression
pattern
Function
type
Description PMID Source
EL0001 116HG Prader-Willi syndrome N/A N/A N/A regulation Long ncRNA 116HG has been shown to play a role in the development of Prader–Willi syndrome (PWS) (Powell et al., 2013). 24624135 LncRNADisease
EL0003 1B FGF-antisense transcripts endometriosis N/A N/A N/A expression Mihalich et al, reported patients with endometriosis show low expression of 1B FGF-antisense transcripts, which correlates with endometrial cell proliferation 23781896 LncRNADisease
EL0004 4930503E24Rik ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0006 51A Alzheimer's disease N/A N/A N/A regulation 51A expression drives a splicing shift of SORL1 from the synthesis of the canonical long protein variant 1 to an alternatively spliced protein form. This process, resulting in a decreased synthesis of SORL1 variant 1, is associated with an impaired processing of APP, leading to increase of A formation. 22996644 LncRNADisease
EL0008 5730458M16Rik heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 22 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0011 9530018H14Rik breast cancer qPCR, Luciferase reporter assay etc. breast cancer tissue, cell lines(NMuMG, 4T1) up-regulated expression The level of expression of lncRNA-HIT in normal breast tissue was low and gradually increased to invasive carcinoma suggesting lncRNA-HIT may play a role in tumor progression in humans. These data further support the findings demonstrating the involvement of lncRNA-HIT in EMT and invasion as observed in NMuMG and 4T1 cells, and suggest that conserved human lncRNA-HIT could play a pivotal role in breast cancer metastasis. 25605728 Lnc2Cancer
EL0012 A130040M12Rik cancer N/A N/A N/A expression These results indicate that PSF is a major tumor-suppressor protein and VL30-1 RNA is a major tumor-promoter RNA in mice. 19805375 LncRNADisease
EL0013 AA174084 gastric cancer qPCR, RIP etc. gastric cancer tissue down-regulated N/A Expression levels of AA174084 were down-regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues. AA174084 levels had significant, negative correlations with age, Borrmann type, and perineural invasion. Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels and were associated with invasion and lymphatic metastasis. AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis. The area under ROC was up to 0.848. 24986041 Lnc2Cancer
EL0014 AATBC bladder cancer microarray, qPCR, in vitro knockdown etc. bladder cancer tissue up-regulated interaction We found that AATBC was overexpressed in bladder cancer patient tissues and positively correlated with tumor grade and pT stage. We also found that inhibition of AATBC resulted in cell proliferation arrest through G1 cell cycle mediated by cyclin D1, CDK4, p18 and phosphorylated Rb. In addition, inhibition of AATBC induced cell apoptosis through the intrinsic apoptosis signaling pathway, as evidenced by the activation of caspase-9 and caspase-3. The investigation for the signaling pathway revealed that the apoptosis following AATBC knockdown was mediated by activation of phosphorylated JNK and suppression of NRF2. 25473900 Lnc2Cancer
EL0015 AB019562 hypopharyngeal squamous cell carcinoma microarray, qPCR etc. primary HSCC tissue up-regulated expression AB209630 expression was significantly lower in carcinomas than in adjacent nontumor tissues. AB019562 expression was significantly higher in carcinomas than in adjacent nontumor tissues. 26131061 Lnc2Cancer
EL0016 AB073614 ovarian cancer microarray, qPCR, Western blot, knockdown, FCA etc. ovarain cancer tissue, cell lines (A2780, Caov3, HO-8910, OVCAR3, SKOV3 etc.) up-regulated interaction Results showed that AB073614 expression was significantly up-regulated in 85.3% (64/75) cancerous tissues compared with normal counterparts. Knockdown of AB073614 expression significantly inhibited cell proliferation and invasion, resulted in cell arrest in G1 phase of cell cycle and a dramatic increase of apoptosis. Finally, western blot assays indicated that lncRNA AB073614 may exert its function by targeting ERK1/2 and AKT-mediated signaling pathway. In conclusion, our study suggests that lncRNA AB073614 acts as a functional oncogene in OC development. 26299803 Lnc2Cancer
EL0016 AB073614 glioma qRT-PCR N/A up-regulated N/A AB073614 expression was significantly up-regulated in cancerous tissues compared with normal brain tissues 27104549
EL0017 AB074278 urothelial carcinoma of the bladder microarray, qPCR, in vitro knockdown etc. urothelial carcinoma of the bladder tissue up-regulated N/A We implicate upregulation of AB074278 in apoptosis avoidance and the maintenance of a proproliferative state in cancer through a potential interaction with EMP1, a tumor suppressor and a negative regulator of cell proliferation. 25165097 LncRNADisease Lnc2Cancer
EL0018 AB209630 hypopharyngeal squamous cell carcinoma microarray, qPCR etc. primary HSCC tissue down-regulated expression AB209630 expression was significantly lower in carcinomas than in adjacent nontumor tissues. AB019562 expression was significantly higher in carcinomas than in adjacent nontumor tissues. 26131061 Lnc2Cancer
EL0018 AB209630 hypopharyngeal squamous cell carcinoma qRT-PCR tissues/cell lines and adjacent normal tissues/cell lines down-regulated N/A increased expression of AB209630 might either stimulate or inhibit biological activities involved in HSCC development 26895099
EL0019 ABHD11-AS1 gastric cancer qPCR etc. gastric cancer tissue up-regulated N/A Results show that compared with adjacent nontumor tissues the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. 24984296 Lnc2Cancer
EL0019 ABHD11-AS1 gastric cancer qPCR etc. gastric cancer tissue, gastric juice up-regulated expression The results showed that ABHD11-AS1 levels in gastric cancer tissues were significantly higher than those in other tissues. Its levels in gastric juice from gastric cancer patients were not only significantly higher than those from cases of normal mucosa or minimal gastritis, atrophic gastritis, and gastric ulcers but also associated with gender, tumor size, tumor stage, Lauren type, and blood carcinoembryonic antigen (CEA) levels. 26280398 Lnc2Cancer
EL0020 Abhd11os neurodegenerative diseases N/A N/A N/A N/A The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo. Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic. 25619660 LncRNADisease
EL0021 Abhd11os NNK-induced rat lung cancer qRT-PCR lung tissue up-regulated N/A level of NR_026689 was determined and significantly increased in rat whole blood at the 10th and 20th 26908441
EL0022 STAG3L2 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0023 AC006050.3-003 lung squamous cell carcinoma N/A N/A N/A N/A The expression of lncRNA AC006050.3-003 was significantly lower in PR samples compared to the PD samples in another 60 lung squamous cell carcinoma patients. Receiver operating characteristic curve analysis revealed that lncRNA AC006050.3-003 was a valuable biomarker for differentiating PR patients from PD patients with an area under the curve of 0.887 (95% confidence interval 0.779, 0.954). 25250788 LncRNADisease
EL0024 LOC101927596 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL0025 MTCO1P5 laryngeal squamous cell carcinoma microarray, qPCR etc. LSCC tissue down-regulated expression AC026166.2-001 and RP11-169D4.1-001 were distinctly dysregulated, with AC026166.2-001 exhibiting lower expression in cancer tissues and RP11-169D4.1-001 higher expression. We verified that both AC026166.2-001 and RP11-169D4.1-001 were expressed at a lower level in cervical lymph nodes compared with paired laryngeal cancer tissues and paired normal tissues. RP11-169D4.1-001 levels were positively correlated with lymph node metastasis. 25243407 Lnc2Cancer
EL0027 PLAC9P1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0028 AC100865.1 coronary artery disease microarray, qPCR plasma from coronary artery disease (CAD) patients up-regulated expression The present study screened lncRNAs by microarray analysis in the plasma from CAD patients and control individuals and found that 265 lncRNAs were differentially expressed. Receiver operating characteristic (ROC) curve analysis showed that lncRNA AC100865.1(referred to as CoroMarker) was the best of these lncRNAs. 26201019
EL0029 AC104699.1 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0030 AC104699.1.1 ovarian cancer high-throughput molecular profiles 399 Ovarian cancer (OV) patients N/A expression Two protective lncRNAs, RP11-284N8.3.1 and AC104699.1.1, were not only differentially expressed throughout the progression of malignant OV but were also independently predictive of the survival of patients with different OV stages. A functional analysis of the two lncRNAs predicted their roles in immune system activation and other anti-tumor processes in the OV microenvironment. 26629053
EL0031 ACTA2-AS1 lung adenocarcinoma microarray, qPCR, knockdown etc. lung adenocarcinoma tissue, cell lines (A549) up-regulated expression Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. 24721325 LncRNADisease Lnc2Cancer
EL0032 ADAMTS9-AS2 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression The expression level of ADAMTS9-AS2, C1401f132 and LINC00312 in NSCLC tumors were indeed significantly down-regulated when compared with those in normal lung tissues, while LINC00673 was significantly up-regulated in NSCLC tumors compared with normal lung tissues.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL0032 ADAMTS9-AS2 glioma qPCR, Western blot, knockdown etc. glioma tumor tissue, cell lines (T98G, A172, SNB-19 etc.) down-regulated regulation A new tumor suppressor?LncRNA?ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells. 24833086 LncRNADisease Lnc2Cancer
EL0033 Adapt15 obesity knockdown mutant Chinese hamster ovary cell line N/A mutation Here we report that gadd7 is induced by lipotoxic stress in a reactive oxygen species (ROS)-dependent fashion and is necessary for both lipid- and general oxidative stress-mediated cell death. Depletion of gadd7 by mutagenesis or short hairpin RNA knockdown significantly reduces lipid and non-lipid induced ROS 19150982
EL0033 Adapt15 diabetes knockdown mutant Chinese hamster ovary cell line N/A mutation Here we report that gadd7 is induced by lipotoxic stress in a reactive oxygen species (ROS)-dependent fashion and is necessary for both lipid- and general oxidative stress-mediated cell death. Depletion of gadd7 by mutagenesis or short hairpin RNA knockdown significantly reduces lipid and non-lipid induced ROS 19150982
EL0034 AF070632 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated expression We noted that LINC01419 was characterized by a significant increase in transcript expression from dysplasia to early HCC. The lncRNA AK021443 was also up-regulated in advanced HCC samples when compared with early HCC. Moreover, expression of LINC01419 and AK021443 was up-regulated in HCC tissues when compared with non-tumor liver tissue. AF070632 expression was down-regulated in HCC and was decreased in advanced HCC when compared with early HCC. These results suggest that LINC01419 may be related to the initiation of HCC, whereas AK021443 and AF070632 may be associated with the progression of HCC. 26540467 Lnc2Cancer
EL0035 AF075041 pancreatic cancer qPCR etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-3 etc.) up-regulated expression We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. 26045769 Lnc2Cancer
EL0036 AF086415 nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) down-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294004) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL0037 AF116616 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue down-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0038 AF118081 lung cancer qPCR, knockdown etc. lung cancer tissue, cell lines (16HBE) up-regulated regulation LncRNA AF118081 was identified as the most significantly overexpressed lncRNA in 16HBE-T cells, lung cancer cells, and patient samples. Cell proliferation, colony formation, apoptosis, migration, and invasion were assayed in 16HBE-T cells following the knockdown of lncRNA AF118081 with small interfering RNA. AF118081 knockdown inhibited cell growth and tumor invasion. An in vivo (nude mouse) model was then used to assay tumor growth, and the downregulation of AF118081 clearly suppressed tumor growth, consistent with the results of the in vitro assays. 25050996 Lnc2Cancer
EL0039 AF339813 pancreatic cancer qPCR, Western blot, knockdown etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-4 etc.) up-regulated interaction We found LncRNA AF339813 was positively regulated by NUF2. We further demonstrated that knockdown of AF339813 by siRNA in PC cells significantly reduced cell proliferation and promoted apoptosis.We further demonstrated that knockdown of AF339813 by siRNA in PC cells significantly reduced cell proliferation and promoted apoptosis. Thus, we conclude that NUF2 is consistently overexpressed in human PC and NUF2 is closely linked with human PC progression through the meditator LncRNA AF339813. 26045769 Lnc2Cancer
EL0040 AFAP1-AS1 nasopharyngeal carcinoma microarray, qPCR, Western blot, knockdown, ISH etc. NPC tissue, cell lines (5-8F, HNE2, HK-1) up-regulated interaction AFAP1-AS1 expression was upregulated in NPC and associated with NPC metastasis and poor prognosis. In vitro experiments demonstrated that AFAP1-AS1 knockdown significantly inhibited the NPC cell migration and invasive capability. AFAP1-AS1 knockdown also increased AFAP1 protein expression. Proteomic and bioinformatics analyses suggested that AFAP1-AS1 affected the expression of several small GTPase family members and molecules in the actin cytokeratin signaling pathway. AFAP1-AS1 promoted cancer cell metastasis via regulation of actin filament integrity. 26246469 Lnc2Cancer
EL0040 AFAP1-AS1 Barrett's esophagus N/A N/A N/A expression Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1, in Barrett's Esophagus and Esophageal Adenocarcinoma. 23333711 LncRNADisease Lnc2Cancer
EL0040 AFAP1-AS1 esophageal squamous cell carcinoma overexpression, Kaplan-Meier survival analysis cisplatin-resistant and parental ESCC cell lines up-regulated expression High expression of AFAP1-AS1 could serve as a potential biomarker to predict tumor response and survival. Determination of this lncRNA expression might be useful for selection ESCC patients for dCRT. 26756568
EL0040 AFAP1-AS1 esophageal adenocarcinoma qPCR etc. EAC tissue, cell lines (OE-33, SK-GT-4, FLO-1, HEEpiC etc.) up-regulated expression Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1, in Barrett's Esophagus and Esophageal Adenocarcinoma. 23333711 LncRNADisease Lnc2Cancer
EL0040 AFAP1-AS1 pancreatic ductal adenocarcinoma qPCR etc. blood, cell lines (Panc1, MIAPaCa-2, Capan2, SW1990 etc.) up-regulated expression Microarray analysis revealed that up-regulation of AFAP1-AS1 expression in PDAC tissues compared with normal adjacent tissues, which was confirmed by RT-qPCR in 69/90 cases (76.7%). Its overexpression was associated with lymph node metastasis, perineural invasion, and poor survival. AFAP1-AS1 is a potential novel prognostic marker to predict the clinical outcome of PDAC patients after surgery and may be a rational target for therapy. 25925763 Lnc2Cancer
EL0040 AFAP1-AS1 non-small cell lung cancer qPCR etc. non-small-cell lung cancer tissue up-regulated expression Results showed that patients with high LncRNA AFAP1-AS1 expression lived shorter than those with low LncRNA AFAP1-AS1 expression (Log rank test, P<0.001). Besides, the prognostic value of LncRNA AFAP1-AS1 as well as the clinical features was assessed by Cox regression analysis. The outcome revealed that LncRNA AFAP1-AS1 was closely related to the prognosis of NSCLC 26463625 Lnc2Cancer
EL0040 AFAP1-AS1 hepatocelluar carcinoma real-time PCR; MTT assay 78 HCC tissues up-regulated N/A AFAP1-AS1 was significantly correlated with pathological staging 26892468
EL0040 AFAP1-AS1 lung cancer RNA-seq, qPCR, Western blot etc. cell line (A549 ) up-regulated interaction AFAP1-AS1 was the most significantly upregulated in lung cancer and associated with poor prognosis. AFAP1-AS1 knockdown significantly inhibited the cell invasive and migration capability in lung cancer cells. AFAP1-AS1 knockdown also increased the expression of its antisense protein coding gene, actin filament associated protein 1 (AFAP1), and affected the expression levels of several small GTPase family members and molecules in the actin cytokeratin signaling pathway, which suggested that AFAP1-AS1 promoted cancer cell metastasis via regulation of actin filament integrity. 26245991 Lnc2Cancer
EL0042 AI364715 gastric cancer qPCR etc. gastric cancer tissue down-regulated expression The expression level of AI364715 in gastric cancer tissues was downregulated. Meanwhile, its expression level was closely associated with tumor size and differentiation. 25971582 Lnc2Cancer
EL0044 Airn alcoholic liver disease N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). 19362547 LncRNADisease
EL0044 Airn chronic nonalcoholic liver disease N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). 19362547 LncRNADisease
EL0044 Airn hepatocelluar carcinoma N/A N/A N/A expression Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). Furthermore, over expression of H19 and AIR was demonstrated in tumors formed in mice withdrawn for 9 months. 19362547 LncRNADisease
EL0045 AK022029 pancreatic cancer qPCR etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-5 etc.) up-regulated expression We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. 26045769 Lnc2Cancer
EL0046 AK022159 pancreatic cancer qPCR etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-6 etc.) up-regulated expression We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. 26045769 Lnc2Cancer
EL0047 AK028007 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0048 AK038798 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 16 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0049 AK042766 Restless legs syndrome N/A N/A N/A expression A recent study suggested that the predisposition to RLS results from reduced expression of Meis1 mediated by intronic cis-regulatory elements. Intriguingly, in the developing mouse brain, Meis1 is co-expressed in the developing cerebellar granule cell layer along with a genomically-associated lncRNA AK042766 19696892 LncRNADisease
EL0050 AK044955 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 7 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0051 AK056988 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL0052 AK057054 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue down-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL0053 AK081227 Rett syndrome microarray, qRT-PCR mice brain up-regulated N/A transcriptional dysregulation of lncRNAs upon Mecp2 loss contributes to the neurological phenotype of Rett syndrome and highlights the complex interaction between ncRNAs and coding-RNAs. 23611944
EL0054 AK093543 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A To validate the microarray analysis results, five lncRNAs were randomly selected from the differential lncRNAs and their expressions were analyzed using qPCR in 29 pairs of HCC and matched NT tissues. Our data indicated that the expressions of TCONS_00018278, AK093543, D16366 and ENST00000501583 were significantly downregulated in HCC, whereas the expression of NR_002819 showed no significant difference. 24876753 Lnc2Cancer
EL0055 AK094838 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue down-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0056 AK095147 nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) down-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294005) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL0057 AK123657 colorectal cancer microarray, qPCR, knockdown etc. cell lines (HCT116 ,SW1116) down-regulated N/A Functional experiments demonstrated three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines. 24809982 Lnc2Cancer
EL0058 AK123790 hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue down-regulated N/A AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. 21769904 Lnc2Cancer
EL0059 AK130977 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL0062 AK139328 liver ischemia/reperfusion injury microarray, qRT-PCR mouse plasma after liver ischemia/reperfusion injury (IRI) up-regulated expression LncRNA AK139328 had been previously reported to be upregulated in the liver after IRI, and silencing of hepatic AK139328 ameliorated liver IRI. microarray and RT-PCR analyses failed to detect the presence of AK139328 in mouse plasma. 26221732
EL0062 AK139328 ischemia/reperfusion N/A N/A N/A regulation Silencing of Long Noncoding RNA AK139328 Attenuates Ischemia/Reperfusion Injury in Mouse Livers. 24312245 LncRNADisease
EL0062 AK139328 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0063 AK143294 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0064 AK143693 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0065 AK153778 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 26 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0066 AKR7L gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue down-regulated N/A TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients; TUSC7 was a direct transcriptional target of p53 via interaction of p53 with the putative p53-response element in the upstream region of TUSC7 25765901 LncRNADisease Lnc2Cancer
EL0067 AL389956 pancreatic cancer qPCR etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-7 etc.) up-regulated expression We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. 26045769 Lnc2Cancer
EL0068 Alg2 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0073 Alu lncRNAs macular degeneration N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL0076 AOC4P colorectal cancer N/A colorectal cancer cells N/A interaction UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its β-transducin repeat-containing protein (TrCP)-mediated ubiquitination. UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells. 26768845
EL0076 AOC4P hepatocelluar carcinoma qPCR, Western blot, RNA pulldown assay, knockdown, HCC tissue, cell lines (J7 and SK-Hep1) down-regulated interaction we identified a differentially expressed novel tumor suppressive lncRNA termed amine oxidase, copper containing 4, pseudogene (AOC4P). The level of AOC4P expression was significantly downregulated in 68% of HCC samples and negatively correlated with advanced clinical stage, capsule invasion and vessel invasion. Low AOC4P expression correlated with poor prognostic outcomes, serving as an independent prognostic factor for HCC. In vitro functional assays indicated that AOC4P overexpression significantly reduced cell proliferation, migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT) 26160837 Lnc2Cancer
EL0077 AP000688.29 enterovirus 71 infection N/A N/A N/A expression A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation (2.25-fold in microarray analysis) was observed in AP000688.29, 3.33-fold up-regulation (2.77-fold in microarray analysis) in AC002511.1, 2.29-fold up-regulation (2.40-fold in microarray analysis) in RP5-843L14.1, and 2.99-fold up-regulation (2.22-fold in microarray analysis) in RP4-620F22.3 23220233 LncRNADisease
EL0078 AP001439.1 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0079 AP5M1 nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) up-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294007) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL0082 APTR glioblastoma qPCR, Northern blot, Luciferase reporter assays, knockdown etc. primary glioblastoma tissue, cell lines (A172, HCT116) up-regulated N/A We identified a novel lncRNA, APTR, that acts in trans to repress the CDKN1A/p21 promoter independent of p53 to promote cell proliferation. 24748121 Lnc2Cancer
EL0083 ARA Cancer microarray, qRT-PCR MCF-7/ADR and HepG2/ADR cells N/A N/A The functions of ARA were assessed by silencing this lncRNA in vitro, and ARA knockdown reduced the proliferation, induced cell death, G2/M arrest and migration defects. modulate multiple signalling pathways, including MAPK signalling pathway, metabolism pathways, cell cycle and cell adhesion-related biological pathways, and regulate cellular processes, including transcriptional processes and protein binding function. 24184505
EL0084 Arid2-IR renal inflammation N/A N/A N/A N/A Arid2-IR is a novel lncRNA that functions to promote NF-KB-dependent renal inflammation. Overexpression of Arid2-IR promoted interleukin-1ǂ-induced NF-NJB signaling and inflammatory cytokine expression without alteration of TGF-beta1-induced fibrotic response. 25743111 LncRNADisease
EL0085 AS Uchl1 Parkinson's disease N/A N/A N/A N/A Uch1 RNA levels are strongly down-regulated in neurochemical models of PD in vitro and in vivo 25883552 LncRNADisease
EL0090 ASK00420 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) down-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL0092 ASLNC00339 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue down-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0093 ASncmtRNAs cancer N/A several tumor cell lines down-regulated N/A the ASncmtRNAs are down-regulated in tumor cells regardless of tissue of origin. down-regulation of the ASncmtRNAs constitutes a vulnerability or Achilles' heel of cancer cells, suggesting that the ASncmtRNAs are promising targets for cancer therapy. 25100722
EL0093 ASncmtRNAs cancer N/A several tumor cell lines down-regulated N/A the ASncmtRNAs are down-regulated in tumor cells regardless of tissue of origin. down-regulation of the ASncmtRNAs constitutes a vulnerability or Achilles' heel of cancer cells, suggesting that the ASncmtRNAs are promising targets for cancer therapy. 25100722
EL0209 Atp2a2 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 4 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0210 ATP6V1G2-DDX39B dilated cardiomyopathy N/A N/A N/A mutation The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. 16101831 LncRNADisease
EL0210 ATP6V1G2-DDX39B hepatitis C virus-associated dilated cardiomyopathy N/A N/A N/A mutation The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. 16101831 LncRNADisease
EL0215 ATXN7L3B spinocerebellar ataxia type 7 N/A N/A N/A N/A STAGA is required for the transcription initiation of miR-124, which in turn mediates the post-transcriptional cross-talk between lnc-SCA7, a conserved long noncoding RNA,and ATXN7 mRNA. In SCA7, mutations in ATXN7 disrupt these regulatory interactions and result in a neuron-specific increase in ATXN7 expression. Strikingly, in mice this increase is most prominent in the SCA7 disease-relevant tissues, namely the retina and cerebellum. 25306109 LncRNADisease
EL0216 ATXN8OS spinocerebellar ataxia type 8 N/A N/A N/A locus Patients show a trinucleotide (CUG) expansion in a noncoding RNA termed ataxin 8 opposite strand (ATXN8OS), an antisense transcript to the KLHL1 gene. 16804541 LncRNADisease
EL0216 ATXN8OS spinocerebellar ataxia type 8 N/A N/A N/A mutation The low prevalence of SCA8 seems to be correlated with the low frequency of large (CTA/CTG)n copy number alleles in Chinese population. 18841561 LncRNADisease
EL0216 ATXN8OS spinocerebellar ataxia type 8 N/A N/A N/A expression Spinocerebellar ataxia type 8 (SCA8) involves bidirectional expression of CUG (ATXN8OS) and CAG (ATXN8) expansion transcripts. 19229559 LncRNADisease
EL0216 ATXN8OS spinocerebellar ataxia type 8 N/A N/A N/A expression RNA gain-of-function plays a significant role in SCA8: 1) CUG(exp) transcripts accumulate as ribonuclear inclusions that co-localize with MBNL1 in selected neurons in the brain. 19680539 LncRNADisease
EL0216 ATXN8OS spinocerebellar ataxia type 8 N/A N/A N/A mutation The ATXN8OS (CTA)n(CTG)n composite repeat expansion is transmitted in an autosomal dominant manner with reduced penetrance. 20301445 LncRNADisease
EL0216 ATXN8OS Spinocerebellar ataxia type 8 N/A N/A N/A Interaction ATXN8OS transcript contributes to SCA8 pathogenesis by altering the activity of MBNL/CELF alternative splicing proteins. 20380817 LncRNADisease
EL0216 ATXN8OS Spinocerebellar ataxia type 8 N/A N/A N/A mutation Expansion repeats in the ATXN8OS lncRNA gene are partly responsible for the pathology of spinocerebellar ataxia type 8 through a toxic RNA gain-of-function mechanism that includes formation of ribonuclear inclusions in the cerebellum and deregulation of muscleblind-like splicing regulator 1-mediated alternative splicing 22814587 LncRNADisease
EL0216 ATXN8OS Spinocerebellar ataxia type 8 N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0217 AX746718 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL0218 AX800134 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated expression We determined that a panel based on the expression of uc001ncr and AX800134 accurately diagnosed HBV-positive HCC (AUC values of 0.9494 and 0.9491 for the training and validation cohorts, respectively). The diagnostic performance of the panel remained high in patients with AFP>=400 ng/ml (AUC values of 0.9371 and 0.9527 for the training and validation cohorts, respectively). The panel also diagnosed early HCC (AUC values of 0.9450 and 0.9564 for the training and validation cohorts, respectively) 26674525 Lnc2Cancer
EL0219 B1 SINE RNA brain ischemia N/A N/A N/A expression SINE B2 was induced by global ischemia after 1 day in Mongolian gerbils. 15016078 LncRNADisease
EL0220 B1 SINE RNA infection of mouse minute virus N/A N/A N/A expression Increased levels of B1 and B2 SINE transcripts in mouse fibroblast cells due to minute virus of mice infection. 15351211 LncRNADisease
EL0222 B2 SINE RNA infection of chicken embryo lethal orphan adenovirus N/A N/A N/A Interaction CELO protein Gam1 was able to mediate transcriptional activation of these B2 SINE-containing RNAs. Upregulation of B2-SINE-containing RNAs could be a novel contribution of Gam1 to CELO host cell infection. 12729754 LncRNADisease
EL0222 B2 SINE RNA heat shock N/A heat shocked cells N/A interaction B2 rna potently inhibits transcription by binding to core pol ii with high affinity and specificity. 15300239
EL0222 B2 SINE RNA heat shock N/A N/A N/A interaction A small noncoding rna polymerase iii transcript, b2 rna, associates with rna polymerase ii and represses transcription of specific mrna genes. 15300240
EL0222 B2 SINE RNA infection of mouse minute virus N/A N/A N/A expression Increased levels of B1 and B2 SINE transcripts in mouse fibroblast cells due to minute virus of mice infection. 15351211 LncRNADisease
EL0222 B2 SINE RNA pain N/A N/A N/A expression Comt1 is differentially expressed among the strains, and this differential expression is cis-regulated. A B2 short interspersed nuclear element (SINE) was inserted in the 3'-untranslated region (3'-UTR) of Comt1 in 14 strains generating a common haplotype that correlates with gene expression. A haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors. 20659173 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A Interaction The BACE1-antisense transcript (BACE1-AS) regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. 18587408 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A brain samples from Alzheimer's disease patients up-regulated interaction BACE1-antisense prevents miRNA-induced repression of BACE1 mRNA by masking the binding site for miR-485-5p 20507594
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A expression The BACE1-antisense transcript (BACE1-AS) is markedly upregulated in brain samples from AD patients and promotes the stability of the (sense) BACE1 transcript. 21785702 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A regulation It has been shown that misexpression of lncRNAs contributes to numerous diseases. For example, an lncRNA may influence the pathogenesis of Alzheimer's disease. The BACE1-AS can regulate BACE1 mRNA expression. BACE1 mRNA expression is under the control of a regulatory non-coding RNA that may drive Alzheimer's disease-associated pathophysiology 22535282 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A expression BACE1 is one of two peptidases that carry out the initial proteolytic cleavage of APP, allowing it to accumulate in the brain. BACE1AS levels were found to be higher in human subjects with AD, and also in BACE1 transgenic mouse models of AD 22817756 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A expression he accumulation of this protein has been implicated in many neurological disorders and elevated levels of both BACE1 and BACE1-AS have been detected in subjects with Alzheimer's disease 22928560 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A expression BACE1-AS is elevated in brains of patients with AD, suggesting that the lncRNA is the driving force behind BACE1 dysregulation in AD 23562612 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0224 BACE1-AS Inclusion body myositis N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A expression The expression of BACE1 antisense transcript (BACE1-AS) was linked to increased amyloid-β 1–42 in patients with Alzheimer’s disease and gave rise for a stabilizing function of the lncRNA. 24531795 LncRNADisease
EL0224 BACE1-AS Alzheimer's disease N/A N/A N/A regulation In Alzheimer disease, the protein-coding gene BACE-1 (β-site amyloid precursor protein-cleaving enzyme) cleaves amyloid precursor protein (APP) to β-amyloid peptide (Aβ), the accumulation of which (amyloid plaques) is associated with disease. LncRNA BACE1-AS, located on the antisense strand to BACE1, binds complementarily to BACE1 mRNA, increases its stability, regulates BACE1 translation, and thereby the production of Aβ. 24667321 LncRNADisease
EL0224 BACE1-AS colon cancer qPCR etc. cell lines (SNU-C4R, SNU-C5R etc.) down-regulated regulation We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. 25078450 Lnc2Cancer
EL0224 BACE1-AS ovarian cancer siRNA human anisomycin-treated ovarian cancer stem cells (OCSCs) up-regulated interaction lncRNA BACE1-AS as a novel target for anisomycin. Elevation of lncRNA BACE1-AS expression is a potential mechanism for suppressing human OCSC proliferation and invasion. 26783004
EL0225 BALR-2 B cell acute lymphoblastic leukemia microarray, qPCR etc. blood (mononuclear cells) up-regulated expression Importantly, high expression of BALR-2 correlated with poor overall survival and diminished response to prednisone treatment. BALR-2 plays a functional role in the pathogenesis and/or clinical responsiveness of B-ALL and that altering the levels of particular lncRNAs may provide a future diretcion for therapeutic development. 25681502 Lnc2Cancer
EL0226 BALR-6 B-lymphoblastic leukemia qPCR, Northern blot, knockdown etc. cell lines(MV, Reh, 697, Nalm-6, 70Z/3, HEK 293) up-regulated interaction Overexpression of BALR-6 in murine bone marrow transplantation experiments caused a significant increase in early hematopoietic progenitor populations, suggesting that its dysregulation may cause developmental changes. Notably, the knockdown of BALR-6 resulted in global dysregulation of gene expression. The gene set was enriched for leukemia-associated genes, as well as for the transcriptome regulated by Specificity Protein 1 (SP1). We confirmed changes in the expression of SP1, as well as its known interactor and downstream target CREB1. Luciferase reporter assays demonstrated an enhancement of SP1-mediated transcription in the presence of BALR-6. These data provide a putative mechanism for regulation by BALR-6 in B-ALL 26694754 Lnc2Cancer
EL0227 BANCR colorectal cancer chromatin immunoprecipitation; luciferase assays; RT-PCR fentanyl-treated colorectal cancer (CRC) cells up-regulated expression Fentanyl induced BANCR upregulation and Ets-1 downregulation in CRC cells. Further studies showed that Ets-1 negatively regulated BANCR expression via the deacetylation of histones H3 within BANCR promoter. Ets-1 overexpression inhibited fentanyl-induced effects that could be reversed by BANCR co-overexpression 26296467
EL0227 BANCR melanoma microarray, RNA-seq, qPCR etc. cell lines (293T, sk-mel-5, Colo-829 etc.) up-regulated N/A BRAF-regulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. 22581800 LncRNADisease Lnc2Cancer
EL0227 BANCR melanoma N/A N/A N/A regulation This screen revealed a 693 bp novel lncRNA transcript, named BRAF-activated non-coding RNA (BANCR).Depletion of BANCR in melanoma cells resulted in profound migration defects, indicating a significant role of BANCR in regulation of melanoma cell motility. 24115003 LncRNADisease
EL0227 BANCR gastric cancer qPCR etc. gastric cancer tissue up-regulated interaction In our results, the expression of BANCR was increased in gastric cancer tissues compared with paired adjacent normal tissues. Moreover, high expression of BANCR was positively associated with clinical stage, tumor depth, lymph node metastasis and distant metastasis in gastric cancer patients. BANCR overexpression was an independent unfavorable prognostic biomarker for gastric cancer patients. 26054683 Lnc2Cancer
EL0227 BANCR retinoblastoma qPCR, knockdown etc. retinoblastoma tissue, cell lines (Weri-Rb1, Y79) up-regulated expression In our results, lncRNA BANCR is overexpressed in retinoblastoma tissues and cell lines and is associated with tumor size, choroidal invasion, and optic nerve invasion. lncRNA BANCR plays a significant role in retinoblastoma aggressiveness and prognosis and may act as a promising target for therapeutic strategy and prognostic prediction. 25894373 Lnc2Cancer
EL0227 BANCR papillary thyroid carcinoma qPCR, knockdown, RIP, FCA etc. PTC tissue, cell line (IHH-4) up-regulated interaction The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. In addition, BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. 26323637 Lnc2Cancer
EL0227 BANCR colorectal cancer qPCR, Western blot etc. colorectal cancer tissue up-regulated N/A The quantitative polymerase chain reaction results showed that BANCR was frequently overexpressed in cancer tissues and this overexpression was found to significantly correlate with lymph node metastasis and tumour stage. The ectopic expression of BANCR contributed to the migration of human CRC Caco-2 cells, whereas knockdown of BANCR inhibited the migration of the HCT116 cells in vitro. Further investigation into the underlying mechanisms responsible for the migratory effects revealed that BANCR induced the epithelial-mesenchymal transition (EMT) through an MEK/extracellular signal-regulated kinase-dependent mechanism as treatment with the MEK inhibitor, U0126 decreased migration and reversed the EMT in the BANCR-overexpressed HCT116 cells. 25013510 Lnc2Cancer
EL0227 BANCR lung cancer qPCR, Western blot etc. lung cancer tissue, cell lines (NCI-H1688, NCI-H446) down-regulated expression The results showed that BANCR levels were downregulated in LC cells. When BANCR expression was improved by tranfetcion with pcDNA-BANCR vetcor, tumor growth was suppressed.Vise versa, when BANCR was knockdown by si-BANCR, cell proliferation and migration of LC were remarkably promoted. We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. 25661343 Lnc2Cancer
EL0227 BANCR papillary thyroid carcinoma qPCR, Western blot, FCA etc. PTC tissue, cells line (IHH-4) up-regulated expression The results revealed that BANCR levels were significantly higher in the PTC tissues and PTC IHH-4 cells compared with the normal controls. Knockdown of BANCR in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that BANCR markedly activated autophagy. Overexpression of BANCR inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the BANCR-overexpressed cells. BANCR overexpression also increased cell proliferation and the inhibition of autophagy abrogated BANCR overexpression-induced cell proliferation. 25289082 Lnc2Cancer
EL0227 BANCR malignant melanoma qPCR, Western blot, in vitro knockdown etc. malignant melanoma tissue, cell lines (A-375, 1205Lu, UACC903, CHL-1 and sk-mel-5 etc.) up-regulated N/A BANCR was abnormally overexpressed in human malignant melanoma cell lines and tissues, and increased with tumor stages.The linkage between BANCR and MAPK pathway may provide a novel interpretation for the mechanism of proliferation regulation in malignant melanoma 24967732 Lnc2Cancer
EL0227 BANCR non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1, NCI-H1975, SK-MES-1 etc.) down-regulated expression Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. 24655544 LncRNADisease Lnc2Cancer
EL0227 BANCR colorectal cancer qPCR, Western blot, knockdown etc. colorectal cancer tissue, cell lines (SW480, HCT116, RQO, HT-29 etc.) down-regulated interaction In this study, we show that BANCR expression was significantly down-regulated in colorectal cancer tissues compared with normal tissues, and overexpression of BANCR suppressed colorectal cancer cell growth in vitro and in vivo.Down_regulation of BANCR contributes to theproliferation of colorectal cancer cells,at least in part,through the regulation of p21 protein. 25928067 Lnc2Cancer
EL0227 BANCR gastric adenocarcinoma qPCR, Western blot, knockdown, MTT assay etc. gastric adenocarcinoma tissue, cell lines (BGC823, SGC7901) up-regulated interaction BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-B1 (P50/105) expression and 3'UTR of NF-B1 activity. Overexpression of NF-B1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-B1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. 26248136 Lnc2Cancer
EL0227 BANCR hepatocellular carcinoma quantitative real-time PCR (qRT-PCR), overexpression, downregulation, flow cytometry, and transwell invasion and migration assays human hepatocellular carcinoma tissues up-regulated expression BANCR may contribute to HCC initiation and progression and would be used as not only a novel prognostic marker but also a potential therapeutic target for this disease. 26758762
EL0227 BANCR osteosarcoma real-time PCR osteosarcoma cell lines and clinical specimens down-regulated N/A BANCR expression was significantly associated with large tumor size; MG-63 cell proliferation 27051014
EL0227 BANCR Eosinophilic esophagitis RNA sequencing healthy controls and patients with active EoE up-regulated expression Repression of BANCR significantly altered the expression of IL-13-induced proinflammatory genes. 24920534
EL0227 BANCR osteosarcoma RT-PCR, Western blotting and CCK-8 assay MG-63 cells up-regulated expression After the construct pcDNA3.1-BANCR (BRAF-regulated lncRNA 1) was transfected into MG-63 cells, RT-PCR, Western blotting and CCK-8 assay showed that BANCR was positively correlated with baicalein. 25893737
EL0228 BC002350 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0229 BC011663 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue down-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL0230 BC014579 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We found that the expression of 7 lncRNAs in preneoplastic lesions and HCC was significantly different. 26540467 Lnc2Cancer
EL0231 BC017743 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL0232 BC023629 pancreatic cancer qPCR etc. pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-8 etc.) up-regulated expression We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. 26045769 Lnc2Cancer
EL0233 BC091525 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0235 BCAR4 breast cancer microarray, qPCR, knockdown etc. cell lines (ZR-75-1, MCF7, BCAR4 etc.) differential expression expression BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. 22892392 LncRNADisease Lnc2Cancer
EL0235 BCAR4 breast cancer N/A N/A N/A N/A BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase. 25416949 LncRNADisease
EL0235 BCAR4 breast cancer qPCR etc. cell line (ZR-75-1) up-regulated N/A Breast cancer anti-estrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells. 16778085 LncRNADisease Lnc2Cancer
EL0235 BCAR4 breast cancer qPCR etc. cell line (ZR-75-1) up-regulated expression BCAR4 is expressed in 27% of primary breast tumors. Forced expression of BCAR4 in human ZR-75-1 and MCF7 breast cancer cells resulted in cell proliferation in the absence of estrogen and in the presence of various antiestrogens.BCAR4 may be a good target for treating antiestrogen-resistant breast cancer. 21506106 LncRNADisease Lnc2Cancer
EL0235 BCAR4 breast cancer qPCR, Western blot etc. cell lines (ZR-75-1, BCAR3, EGFR etc.) up-regulated expression High BCAR4 mRNA levels were associated with poor MFS and overall survival, reflecting tumour aggressiveness. 20859285 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 esophageal cancer ISH, Northern hybridization etc. esophageal cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 cervical cancer ISH, Northern hybridization etc. cervical cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 ovarian cancer ISH, Northern hybridization etc. ovarian cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 parotid cancer ISH, Northern hybridization etc. parotid cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 breast cancer ISH, Northern hybridization etc. breast cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 tongue cancer ISH, Northern hybridization etc. tongue cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 lung cancer ISH, Northern hybridization etc. lung cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 breast cancer microarray, ISH etc. breast cancer tissue up-regulated expression In ductal carcinomas in situ, furthermore, significant BC200 (BCYRN1) expression was associated with high nuclear grade, suggesting that the presence of BC200 RNA in such tumors may be used as a prognostic indicator of tumor progression. 15240511 LncRNADisease Lnc2Cancer
EL0237 BCYRN1 Alzheimer's disease N/A N/A N/A expression In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains. 17553964 LncRNADisease
EL0237 BCYRN1 Alzheimer's disease N/A N/A N/A expression Increased levels of BC200 were found in brain regions that are preferentially affected in AD. Further, in advanced stages of AD, BC200 was mis-localized and clustered in the perikaryon. These observations suggest that deregulation of these synaptic lncRNAs is involved in the synaptic and neural network dysfunction that is found in both early and later stages of AD. 20380817 LncRNADisease
EL0237 BCYRN1 Alzheimer's disease N/A N/A N/A expression BC200 levels in Brodmann's area 9 (the area of brain affected in AD) were found to be higher in age-matched AD brains compared with normal brains, and the relative levels of BC200 RNA in affected areas increased with the severity of AD. 23562612 LncRNADisease
EL0237 BCYRN1 ovarian cancer ovarian cancer tissue and normal ovarian tissue samples ovarian cancer tissue and normal ovarian tissue samples up-regulated N/A tumor suppressive function in ovarian cancer by affecting cell proliferation 26893717
EL0237 BCYRN1 glioma qPCR etc. cell lines(U251, U87) down-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
EL0237 BCYRN1 non-small-cell lung cancer RT-PCR, knowdown, over-expression, ChIP non-small-cell lung cancer (NSCLC) up-regulated expression These findings uncover a regulatory mechanism in NSCLC cells involving the metastasis-promoting lncRNA BCYRN1 that improves expressions of the key metastasis-supporting proteins MMP9 and MMP13. 25866480
EL0239 BDNF-AS obesity N/A N/A N/A mutation Association identified by GWAS (rs4074134, A118887G). 19079260 LncRNADisease
EL0239 BDNF-AS obesity N/A N/A N/A locus This locus maps near key hypothalamic regulators of energy balance, may be associated with obesity. 20935630 LncRNADisease
EL0239 BDNF-AS depression N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
EL0239 BDNF-AS Huntington's disease N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
EL0239 BDNF-AS schizophrenia N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
EL0239 BDNF-AS psychiatric disease N/A N/A N/A regulation Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels. 23831425 LncRNADisease
EL0239 BDNF-AS Huntington's disease N/A N/A N/A regulation Thus, BDNF-AS inhibits BDNF transcription by recruiting EZH2 to the BDNF promoter region and in that way plays an important role in the development of HD. 24624135 LncRNADisease
EL0240 BE503655 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0242 BGLT3 chronic myeloid leukemia microarray, qPCR, Western blot etc. cell lines (K562) up-regulated N/A We observed that lncRNA-BGL3 was highly induced in response to disruption of Bcr-Abl expression or by inhibiting Bcr-Abl kinase activity in K562 cells and leukemic cells derived from CML patients. Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. 24837367 Lnc2Cancer
EL0243 BISPR virus infection RNA-seq, qRT-PCR cells infected with hepatitis C virus and in the liver of infected patients up-regulated expression lncBST2/BISPR, are increased in cells infected with hepatitis C virus and in the liver of infected patients. These results allow us to hypothesize that several lncRNAs could be activated by IFN to control the potency of the antiviral IFN response. 25620967
EL0244 BLACAT1 bladder cancer microarray, qPCR, knockdown, ISH etc. bladder cancer tissue, cell lines (J82, UMUC-3, HT-1376, T24, 5637 etc.) up-regulated N/A qPCR confirmed that linc-UBC1 expression is up-regulated in 60 cases (58.8%) in bladder cancer tissues compared with normal adjacent tissues, and its overexpression correlates with lymph node metastasis and poor survival. Further functional analysis demonstrated that knockdown of linc-UBC1 attenuates bladder cancer cell proliferation, motility, invasion, colony formation ability, tumorigenicity and metastatic potential. RIP and ChIP assay confirmed that linc-UBC1 physically associates with PRC2 complex and regulates histone modification status of target genes. 23688781 Lnc2Cancer
EL0244 BLACAT1 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL0244 BLACAT1 gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) up-regulated expression We found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells.Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. 25755750 Lnc2Cancer
EL0245 BM742401 gastric cancer RNA-seq, qPCR, in vitro knockdown etc. gastric cancer tissue, cell lines (B16F1) down-regulated N/A BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. 23846333 Lnc2Cancer
EL0246 BOK-AS1 cancer N/A N/A N/A expression The expression of BOKAS was found in testis and certain cancer tissues but not in other normal adult tissues. Overexpression of BOKAS was able to inhibit Bok-induced apoptosis in HeLa cells. 24757675 LncRNADisease
EL0246 BOK-AS1 testicular cancer qPCR etc. cell line (Hela) up-regulated expression A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. The mRNA expression of BOKAS was only detected in testis and certain cancer tissues but not in other normal adult tissues examined. 19287972 LncRNADisease Lnc2Cancer
EL0246 BOK-AS1 esophageal squamous cell carcinoma qPCR, Western blot, RIP etc. ESCC tissue up-regulated interaction LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance.WISP1 facilitated its own expression in response to radiation, creating a positive feedback loop and increased radioresistance. Our study revealed WISP1 as a potential target to overcome radioresistance in ESCC. 25749038 Lnc2Cancer
EL0248 BPESC1 blepharophimosis syndrome N/A N/A N/A mutation BPESC1 is disrupted by a balanced chromosomal translocation, t(3;4)(q23;p15.2), in a patient with BPES. 10995571 LncRNADisease
EL0250 Bvht cardiac lineage N/A N/A N/A regulation Boyer et al at Massachusetts Institute of Technology have begun to study lncRNAs important for heart development and have identified a novel lncRNA (AK143260) required for specification of the cardiac lineage in vitro 23104877 LncRNADisease
EL0250 Bvht cardiovascular disease N/A N/A N/A expression Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm toward a cardiac fate. 23352431 LncRNADisease
EL0251 BX647187 prostate cancer qPCR, Western bolt, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, PC3, Du145) differential expression interaction Our results showed that Hec1 mRNA and protein were significantly overexpressed in Human PCa tissues and several PCa cell lines. Silencing Hec1 markedly suppressed proliferation, promoted apoptosis and induced cell-cycle arrest in G2/M-phase in PCa cells. Through bioinformatics analysis and knockdown Hec1 in PCa cells, we found LncRNA BX647187 was positively regulated by Hec1. We further demonstrated that suppression of BX647187 in PCa cells significantly reduced cell proliferation and promoted apoptosis. 26612002 Lnc2Cancer
EL0252 BX648207 colorectal cancer microarray, qPCR, knockdown etc. cell lines (HCT116 ,SW1116) down-regulated N/A Functional experiments demonstrated three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines. 24809982 Lnc2Cancer
EL0254 C1401f132 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression The expression level of ADAMTS9-AS2, C1401f132 and LINC00312 in NSCLC tumors were indeed significantly down-regulated when compared with those in normal lung tissues, while LINC00673 was significantly up-regulated in NSCLC tumors compared with normal lung tissues.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL0255 C14orf132 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) down-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL0256 C1orf74 gastric cancer qPCR, Western blot etc. cell lines (SGC7901, BGC823, SGC7901/DDP, BGC823/DDP etc.) up-regulated interaction The expression of lncRNA AK022798 was significantly higher in all pcDNA3-Notch 1 plasmid treatment groups than in the pcDNA3 plasmid treatment group (P< 0.01).Overexpression of lncRNA AK022798 promotes SGC7901/DDP and BGC823/DDP cells apoptosis.the expression of MRP1 and P-glycoprotein decreased significantly in SGC7901/DDP and BGC823/DDP cells, and their apoptosis as well as the expressions of caspase 3 and caspase 8. 25763542 Lnc2Cancer
EL0257 PCOTH prostate cancer qPCR, Northern blot etc. prostate cancer tissue, cell lines (LNCaP, DU145, PC-3CaP etc.) up-regulated expression PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. 15930275 LncRNADisease Lnc2Cancer
EL0258 C2dat1 cerebral ischemia knockdown mouse cortical penumbra up-regulated N/A lncRNA C2dat1 that modulates the expression of CaMKIIδ to impact neuronal survival 27031970
EL0259 C530045E16Rik heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 5 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0260 C5orf66-AS1 esophageal squamous cell carcinoma microarray, qPCR etc. cell lines (KYSE510, KYSE450, KYSE150, KYSE30, EC109, TE-1) down-regulated expression We identified a novel nuclear-retained lncRNA, named Epist, which is generally highly expressed in esophagus, and which is down-regulated during ESCC progression. Epist over-expression and knockdown studies further suggest that Epist inhibits the metastasis, acting as a tumor suppressor in ESCC. Collectively 26158411 Lnc2Cancer
EL0260 C5orf66-AS1 bladder cancer microarray, qPCR, knockdown etc. bladder cancer tissue down-regulated N/A Four lncRNAs were selected for further confirmation of microarray results using qPCR. These lncRNAs were among the most downregulated or upregulated lncRNAs. Data analysis showed that KRT19P3 was upregulated and TNXA, CTA-134P22.2 and CTC-276P9.1 were downregulated in bladder cancer samples compared with matched normal tissues.these deregulated lncRNAs play a key or partial role in the development and/or progression of bladder cancer. 24944692 Lnc2Cancer
EL0261 C5T1lncRNA rheumatoid arthritis knockdown RA-relevant cell types N/A interaction N/A 26673966
EL0264 CACNAICAS3 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0265 CADM1 clear cell renal cell carcinoma qPCR, knockdown etc. renal cancer tissue, cell lines(786-O, ACHN etc.) down-regulated interaction The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens. Decreased CADM1-AS1 expression was correlated with the progression of AJCC stage and worse survival of ccRCC patients. Also, multivariate analysis identified low CADM1-AS1 expression as an independent prognostic factor for ccRCC.CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of CADM1-AS1/CADM1 mRNA gene pairs. 25031695 Lnc2Cancer
EL0265 CADM1 glioma qPCR, knockdown etc. glioma cancer tissue, cell lines ( U87, U251, SNB-19 etc.) down-regulated expression The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, and negatively associated with the WHO criteria of the tumors. Overexpression of TSLC1-AS1 resulted in up-regulation of TSLC1 and significant inhibition of cell proliferation, migration and invasion in U87 cells, while knockdown of TSLC1-AS1 in SNB-19 cells showed the opposite effetc. The expression of TSLC1-AS1 was also positively correlated with other tumor suppressors NF1, VHL, PIK3R1 and negatively correlated with the oncogene BRAF. 25031725 Lnc2Cancer
EL0266 CADM3-AS1 bladder cancer microarray, qPCR, knockdown etc. bladder cancer tissue down-regulated N/A Four lncRNAs were selected for further confirmation of microarray results using qPCR. These lncRNAs were among the most downregulated or upregulated lncRNAs. Data analysis showed that KRT19P3 was upregulated and TNXA, CTA-134P22.2 and CTC-276P9.1 were downregulated in bladder cancer samples compared with matched normal tissues.these deregulated lncRNAs play a key or partial role in the development and/or progression of bladder cancer. 24944692 Lnc2Cancer
EL0267 CAHM colorectal cancer qPCR, qMSP etc. blood, colorectal cancer tissue down-regulated N/A A reverse transcriptase-qPCR assay showed that CAHM RNA levels correlated negatively with CAHM % methylation, and therefore CAHM gene expression is typically decreased in CRC. Both the frequency of detection and the amount of methylated CAHM DNA released into plasma increased with increasing cancer stage. 24799664 Lnc2Cancer
EL0268 CAI2 neuroblastoma qPCR etc. neuroblastoma tissue, cell line (NMB7) up-regulated N/A Concordant expression of CAI2 with p16 and ARF in normal tissue along with the ability of CAI2 to induce p16 expression suggested that CAI2 may regulate p16 and/or ARF. In neuroblastoma cells transformed by serial passage in vitro, leading to more rapid proliferation, CAI2, p16, and ARF expression all increased dramatically. Consistent with its association with high-risk disease, CAI2 expression was also significantly associated with poor clinical outcomes, although this effect was reduced when adjusted for MYCN amplification. 25028366 Lnc2Cancer
EL0271 CASC15 neuroblastoma RNA-seq, qPCR, knockdown, Luciferase reporter assay, RNA-FISH etc. Neuroblastoma cell lines down-regulated mutation Here we report that the most highly significant single-nucleotide polymorphism (SNP) associations reside within CASC15, a long noncoding RNA that we define as a tumor suppressor at 6p22. Low-level expression of a short CASC15 isoform (CASC15-S) associated highly with advanced neuroblastoma and poor patient survival. 26100672 Lnc2Cancer
EL0272 CASC2 endometrial cancer N/A N/A N/A mutation CASC2, in a region of common allelic loss at chromosome 10q26 is a novel candidate gene in human endometrial cancer. 15024726 LncRNADisease
EL0272 CASC2 glioma qPCR, Luciferase reporter assay etc. glioma tissue, cell lines (U251, U87) down-regulated regulation In this study, we confirmed that CASC2 was lowly expressed in glioma tissues as well as in U251 and U87 glioma cell lines. Overexpression of CASC2 inhibited the malignancy of glioma cells, including proliferation, migration, and invasion, and promoted cell apoptosis.We found that up-regulated CASC2 decreased the expression of miR-21 significantly and there is a reciprocal repression between CASC2 and miR-21 in an Argonaute2-dependent manner. 25446261 Lnc2Cancer
EL0272 CASC2 non-small cell lung cancer qRT-PCR, overexpression N/A down-regulated expression CASC2 is involved in the development and progression of NSCLC and shows that CASC2 may be a potential diagnostic and target for new therapies in patients with NSCLC. 26790438
EL0273 CASC9 esophageal squamous cell carcinoma LncRNA array, qRT-PCR, knockdown Primary tumor tissue from four esophageal squamous cell carcinoma (ESCC) patients. up-regulated expression ESCCAL-1 is overexpressed in 65% of an independent ESCC patient cohort (n=26). More over, knockdown of ESCCAL-1 expression increases esophageal cancer cell apoptosis and reduces the invasion in vitro. ESCCAL-1 is a novel putative onco-lncRNA in esophageal cancer development. 25885227
EL0273 CASC9 esophageal squamous cell carcinoma lncRNA microarray, qRT-PCT esophageal squamous cell carcinoma (ESCC) tissue up-regulated expression ESCCAL_1 and HOTAIR may participate in the pathological process of ESCC. Furthermore, lncRNA could be potential diagnostic and prognostic biomarkers for ESCC. 25297587
EL0273 CASC9 esophageal squamous cell carcinoma microarray, qPCR etc. ESCC tissue up-regulated expression In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5. 24222893 LncRNADisease Lnc2Cancer
EL0274 CBR3-AS1 prostate cancer N/A N/A N/A regulation Oncogene; putative therapeutic target 24373479 LncRNADisease
EL0274 CBR3-AS1 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) up-regulated expression Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. 24337686 LncRNADisease Lnc2Cancer
EL0274 CBR3-AS1 prostate cancer qPCR, Western blot etc. cell line (LNCaP, PC-3, C4-2 etc.) up-regulated Interaction The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 (CBR3-AS1) modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. 22264502 LncRNADisease Lnc2Cancer
EL0275 CCAL colorectal cancer microarray, qPCR etc. CRC tissue up-regulated interaction We identified colorectal cancer-associated lncRNA (CCAL) as a key regulator of CRC progression. Patients whose tumours had high CCAL expression had a shorter overall survival and a worse response to adjuvant chemotherapy than patients whose tumours had low CCAL expression.Our results suggest that CCAL is a crucial oncogenic regulator involved in CRC tumorigenesis and progression. 25994219 Lnc2Cancer
EL0276 CCAT1 acute myeloid leukemia gain- and loss-of-function analysis French-American-British M4 and M5 subtypes of adult AML patients up-regulated N/A repressed monocytic differentiation and promoted cell growth of HL-60 26923190
EL0276 CCAT1 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL0276 CCAT1 gastric cancer N/A gastric cancer (GC) cells and tissues up-regulated N/A CCAT1 regulates miR-490 26825578
EL0276 CCAT1 gastric cancer N/A N/A N/A expression Level of lncRNA CCAT1 was markedly increased in gastric carcinoma tissue comparing with normal tissue, and overexpressed CCAT1 promoted cancer cell proliferation and migration 24757675 LncRNADisease
EL0276 CCAT1 gastric cancer N/A N/A N/A expression Another study reported that lncRNA CCAT1 was up-regulated in gastric carcinoma tissues, and its expression was closely related to the transcription factor c-Myc. 24833871 LncRNADisease
EL0276 CCAT1 gastric cancer qPCR etc. gastric cancer tissue up-regulated expression AGS human gastric carcinoma cell line showed an elevated level of CCAT1 expression. Expression levels of CCAT1 were approximately 10.8 fold higher in GC samples than in samples taken from the negative control group. Interestingly, CCAT1 expression was significantly overexpressed in adjacent normal tissues when compared to the negative control group. Tissues obtained from recurrent GC cases showed the highest expression levels. Expression levels increased with tumor stage, however this did not reach statistical significance. 25561974 Lnc2Cancer
EL0276 CCAT1 colorectal cancer qPCR etc. CRC tissue up-regulated interaction The expression of IncRNA-CCAT1 in tumor tissue was significantly higher than that in normal para-carcinoma tissue, and the expression level of CCAT1 was significantly correlated with local infiltration depth , tumor staging, vascular invasion and CA19-9 level, it mediates the EMT process of colorectal cancer. 26064266 Lnc2Cancer
EL0276 CCAT1 hepatocelluar carcinoma qPCR etc. HCC tissue, cell lines (L-02, HepG2, SNU423, SMMC-7721, Hep3B) up-regulated expression The results indicated that the expression of CCAT1 was significantly increased in HCC tissues and cells compared with controls. We also found that the abnormally expressed CCAT1 could promote cell proliferation, migration and invasion. Taken together, our findings demonstrated that the aberrant expression of CCAT1 promotes hepatocellular carcinoma in vitro 26191246 Lnc2Cancer
EL0276 CCAT1 hepatocelluar carcinoma qPCR etc. Liver cancer cell lines (HepG2, Hep3B, SK-HEP1, SMMC7721, MHCC97-L, MHCC97-H, PLC/PRF/5, HCCLM3) up-regulated expression The results showed that CARLo-5 levels were significantly overexpressed in HCC tissues compared to ANLT. Besides, high expression of CARLo-5 was associated with liver cirrhosis (P = 0.001), tumor number (P < 0.001), vascular invasion (P = 0.001), capsular formation (P = 0.014) and Edmondson-Steiner grade (P < 0.001), which proved that CARLo-5 was an independent risk factor for overall survival and disease-free survival. In addition, in highly metastatic HCC cell lines (HCCLM3 and MHCC97-L), CARLo-5 was up-regulated, but in lowly metastatic HCC cell lines (HepG2, SNU387), it showed down-regulated. Besides, by using gain and loss of function experiments in HCC cell lines (HCCLM3 and HepG2), the results showed that CARLo-5 overexpression significantly enhanced cell proliferation, migration and invasion in vitro. Our study also revealed that CARLo-5 was prominently up-regulated in HCC specimens and its high expression was associated with poor prognosis of HCC patients 26433964 Lnc2Cancer
EL0276 CCAT1 breast cancer qPCR etc. BC tissue up-regulated expression Expression levels of lncRNA CCAT1 in BC tissues were significantly higher than those in adjacent normal tissues. High expression of lncRNA CCAT1 was associated with differentiation grade, TNM stage, and lymph node metastases. Kaplan-Meier analysis with the log-rank test indicated that high expression of lncRNA CCAT1 had a decreased overall survival and progression-free survival. Multivariable analysis was further identified high expression of lncRNA CCAT1 as an independent prognosis factor for overall survival and progression-free survival. 26464701 Lnc2Cancer
EL0276 CCAT1 colorectal cancer qPCR, ISH etc. cell lines (SW-480, HT-29, HT29, SW-480 etc.) up-regulated expression Recently, colon cancer associated transcript 1 (CCAT1) lncRNA was found to be expressed in colorectal cancer (CRC) tumors but not in normal tissue. 23416875 LncRNADisease Lnc2Cancer
EL0276 CCAT1 colon cancer qPCR, ISH etc. colonic adenoma-carcinoma tissue up-regulated N/A CCAT1 is up-regulated across the colon adenoma-carcinoma sequence. This up-regulation is evident in pre-malignant conditions and through all disease stages, including advanced metastatic disease suggesting a role in both tumorigenesis and the metastatic process. 23594791 Lnc2Cancer
EL0276 CCAT1 colorectal cancer qPCR, knockdown etc. primary prostatecancer tissue up-regulated N/A CARLo-5 is highly expressed in CRC-derived cell lines compared with normal colon-derived fibroblasts and CRC primary tissues compared with their matched normal adjacent tissues (NATs). In addition, CARLo-5 is highly expressed in prostate cancer (PC) tissues compared with their NATs. CARLo-5 is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. 24594601 Lnc2Cancer
EL0276 CCAT1 gallbladder cancer qPCR, Luciferase reporter assay, Western blot etc. gallbladder cancer tissue up-regulated expression In this study, we demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues. CCAT1 silencing downregulated, whereas CCAT1 overexpression enhanced the expression of miRNA-218-5p target gene Bmi1 through competitively 'spongeing' miRNA-218-5p. Our data revealed that CCAT1 knockdown impaired the proliferation and invasiveness of GBC cells, at least in part through affetcing miRNA-218-5p-mediated regulation of Bmi1. Moreover, CCAT1 transcript level was correlated with Bmi1 mRNA level in GBC tissues. 25569100 Lnc2Cancer
EL0276 CCAT1 gastric cancer qPCR, Western blot, in vitro knockdown etc. gastric cancer tissue up-regulated expression In the present study, a great upregulation of CARLo-5 was observed in gastric cancer compared to paired adjacent normal tissues. Knockdown of CARLo-5 in gastric cancer cell lines significantly inhibited the cell proliferation via inducing G0/G1 cell-cycle arrest and apoptosis. 25674211 Lnc2Cancer
EL0276 CCAT1 non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1, NCI-H1975) up-regulated interaction In the present study, a great upregulation of CARLo-5 was observed in cancer tissues compared to their adjacent normal tissues. Meanwhile, patients with high CARLo-5 expression have significantly poorer prognosis than those with low expression. Inhibition of CARLo-5 by siRNA suppressed the proliferation, migration, and invasion in NSCLC cell lines in vitro. In addition, silencing of CARLo-5 reversed the epithelial-mesenchymal transition in NSCLC cell line. 25129441 Lnc2Cancer
EL0276 CCAT1 gastric cancer qPCR, Western bolt, knockdown, Luciferase reporter assay, RIP etc. gastric carcinoma tissue, cell lines (AGS, MKN45) up-regulated regulation Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. 23143645 LncRNADisease Lnc2Cancer
EL0277 CCAT1-L colorectal cancer qPCR, in vitro knockdown etc. cell lines (HT29, HCT116) up-regulated N/A CCAT1-L plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. 24662484 Lnc2Cancer
EL0278 CCAT2 breast cancer microarray, qPCR, knockdown etc. breast cancer tissue, cell lines (SUM149, SUM190, MDA-MB-231, MDA-MB-436 etc.) up-regulated expression CCAT2, a novel long non-coding RNA in breast cancer. 24077681 LncRNADisease Lnc2Cancer
EL0278 CCAT2 colon cancer qPCR etc. colon cancer tissue up-regulated interaction Our results revealed that CCAT1 was significantly overexpressed in colon cancer tissues when compared with normal tissues, and its increased expression was correlated with patients' clinical stage, lymph nodes metastasis, and survival time after surgery. Moreover, c-Myc could promote CCAT1 transcription by diretcly binding to its promoter region, and upregulation of CCAT1 expression in colon cancer cells promoted cell proliferation and invasion. 25185650 Lnc2Cancer
EL0278 CCAT2 esophageal squamous cell carcinoma qPCR etc. ESCC tissue, cell lines (KYSE410) up-regulated expression In silico analysis showed that no CpG island is found in the chromosome region of CCAT2, indicating that the expression of CCAT2 is possibly not regulated by DNA methylation.Compared with paired adjacent normal esophageal tissues, CCAT2 was significantly overexpressed in ESCC tissues with an average fold of 7.18. In ESCC cell lines, CCAT2 was mostly upregulated in KYSE410 cell when normalized to normal esophageal epithelium cell line (HEEC) and most CCAT2 transcripts were located in nucleus (>95 %). Statistical analysis showed that CCAT2 expression level was significantly associated with smoking status. 25677908 Lnc2Cancer
EL0278 CCAT2 esophageal squamous cell carcinoma qPCR etc. ESCC tissue up-regulated expression CCAT2 was upregulated in ESCC tissues, especially in cases with lymph node metastasis (LNM), advanced TNM stages, and MYC amplification. Furthermore, the level of CCAT2 was positively correlated with TNM stages, LNM, and the number of positive lymph nodes. High CCAT2 expression and MYC amplification were significantly associated with TNM stages and LNM. CCAT2 may have great potential prognostic value for assessing postoperative ESCC patients. 25919911 Lnc2Cancer
EL0278 CCAT2 non-small cell lung cancer qPCR, knockdown etc. NSCLC tissue, cell lines (A549, NCI-H1975, NCI-H358, NCI-H1650, NCI-H1299, SK-MES-1 etc.) up-regulated regulation CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. 24504682 LncRNADisease Lnc2Cancer
EL0278 CCAT2 gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) up-regulated expression Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. By statistical analyses, high lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. 25755774 Lnc2Cancer
EL0278 CCAT2 colorectal cancer qPCR, RIP etc. CRC tissue, cell lines (COLO320DM, HCT116, RKO, HEK293 etc.) up-regulated N/A Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation on the SNP-conferred cancer risk. 23796952 Lnc2Cancer
EL0278 CCAT2 breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue and adjacent normal breast tissue, cell lines (MDA-MB-231, MCF-7) up-regulated interaction We first confirmed the high expression level of CCAT2 in breast cancer tissues and breast cancer cell lines by reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay, and we further analyzed the relationship between CCAT2 expression and clinical prognostic factors. Also, the biological function of CCAT2 was explored and the results showed silencing of CCAT2 could suppress cell growth in vitro and tumor formation in vivo. Finally, our results revealed that the abnormal expression of CCAT2 could influence the Wnt signaling pathway. 26442763 Lnc2Cancer
EL0278 CCAT2 cervical squamous cell cancer qRT-PCR 123 cervical squamous cell tumor specimens up-regulated expression High expression of lncRNA CCAT2 is related to the prognosis of cervical squamous cell cancer. 26722527
EL0278 CCAT2 cervical cancer quantitative real-time PCR cervical cancer cell lines up-regulated N/A CCAT2 knockdown inhibited cell proliferation in HeLa, CaSki and SiHa cells 26983975
EL0279 CCAT3 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0280 CCAT7 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) down-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0281 CCAT8 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) down-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0282 CCDC26 acute myeloid leukemia microarray, qPCR, Western blot etc. cell lines (HL-60, K562 etc.) up-regulated interaction We found that CCDC26 transcripts were abundant in the nuclear fraction of K562 human myeloid leukemia cells. We suggest that CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression.A KIT inhibitor might be an effective treatment against the forms of AML in which CCDC26 is altered. 25928165 Lnc2Cancer
EL0282 CCDC26 glioma N/A N/A N/A mutation In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 脳 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. 23399484 LncRNADisease
EL0283 CCEPR cervical cancer qPCR, Western blot, knockdown, RNA pull-down assay etc. cervical cancer tissue, cell lines (HeLa, SiHa) up-regulated interaction In this study, we found that cervical carcinoma high-expressed lncRNA 1 (lncRNA-CCHE1) was significantly upregulated in cervical cancer tissues. The higher expression of CCHE1 was significantly correlated with large tumor size, advanced Federation of Gynecology and Obstetrics stage, uterine corpus invasion, and poor survival. CCHE1 plays a pivotal role in cervical cancer cell proliferation via increasing PCNA expression and serves as a potential prognostic biomarker and therapeutic target in human cervical cancer. 25921283 Lnc2Cancer
EL0285 CCND1 tumor N/A N/A N/A regulation Binding to TLS protein induces TLS allosteric change, allowing interaction with cyclin D1, inhibiting CBP and p300 activity, and silencing cyclin D1 gene expression. 22996375 LncRNADisease
EL0285 CCND1 cervical cancer qPCR etc. cell line (CaSki) up-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL0287 CD99P1 idiopathic pulmonary fibrosis RT-PCR lungs of IPF (idiopathic pulmonary fibrosis) patients up-regulated expression Further studies revealed that silencing the lncRNA CD99 molecule pseudogene 1 (CD99P1) inhibited proliferation and α-smooth muscle actin expression of lung fibroblasts 26269497
EL0288 Cdc28 lncRNA osmostress whole-genome tiling arrays N/A N/A interaction Cdc28 lncRNA mediates the establishment of gene looping and the relocalization of Hog1 and RSC from the 3' UTR to the +1 nucleosome to induce CDC28 expression. 24508389
EL0289 CDKN2B-AS1 acute lymphoblastic leukemia MassARRAY assay etc. acute lymphoblastic leukemia tissue differential expression mutation rs564398 (A>G), mapping to the CDKN2BAS locus that encodes for ANRIL antisense non-coding RNA, showed a statistically significant correlation with the ALL phenotype, with a risk pattern that was compatible with an overdominant model of disease susceptibility. 21414664 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 neurofibromatosis type 1 microarray, qPCR etc. blood up-regulated mutation Single-nucleotide polymorphism rs2151280 (C>T, located in ANRIL) was statistically significantly associated with the number of PNFs (P < .001) in NF1 patients. In addition, allele T of rs2151280 was statistically significantly associated with reduced ANRIL transcript levels (P < .001), suggesting that modulation of ANRIL expression mediates PNF susceptibility. 22034633 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs (rs2891168, A>G) in the ANRIL locus on chromosome 9p. 18048406 LncRNADisease
EL0289 CDKN2B-AS1 acute lymphoblastic leukemia N/A N/A N/A expression Higher p15AS levels were often found in acute lymphoblastic (ALL) and myeloid leukemias (AML). 21874119 LncRNADisease
EL0289 CDKN2B-AS1 acute myocardial infarction N/A N/A N/A N/A Level of ANRIL was lower in patients with MI (P=0.003)Patients with ST-segment-elevation MI had lower level of ANRIL (P<0.001)when compared with patients with non-ST-segment-elevation MI. 25035150 LncRNADisease
EL0289 CDKN2B-AS1 melanoma N/A N/A N/A mutation Association identified by GWAS. 17440112 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. 17463248 LncRNADisease
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Association identified by GWAS. 17463249 LncRNADisease
EL0289 CDKN2B-AS1 myocardial infarction N/A N/A N/A mutation Association identified by GWAS. 17478679 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A mutation Association identified by GWAS (rs10757274, A>G;rs2383206, A>G). 17478681 LncRNADisease
EL0289 CDKN2B-AS1 coronary artery disease N/A N/A N/A mutation Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a markedly increased risk (rs3217992, A>G;rs1063192, C>T) of coronary artery disease (CAD), the leading cause of death worldwide. 17554300 LncRNADisease
EL0289 CDKN2B-AS1 coronary artery disease N/A N/A N/A mutation Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs (rs2891168, A>G) in the ANRIL locus on chromosome 9p. 18048406 LncRNADisease
EL0289 CDKN2B-AS1 Alzheimer's disease N/A N/A N/A mutation Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. 18761660 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A mutation Association identified by GWAS (rs1333040, C>T). 18997786 LncRNADisease
EL0289 CDKN2B-AS1 myocardial infarction N/A N/A N/A mutation association identified by GWAS (rs4977574, A>G). 19198609 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A locus CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases. 19214202 LncRNADisease
EL0289 CDKN2B-AS1 periodontitis N/A N/A N/A locus CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases. 19214202 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation Genotypes of rs10757278 linked to increased risk of atherosclerotic diseases are also associated with decreased expression in PBTL of the INK4/ARF locus, near CDKN2B-AS1 locus. 19343170 LncRNADisease
EL0289 CDKN2B-AS1 aortic aneurysm N/A N/A N/A expression Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. 19343170 LncRNADisease
EL0289 CDKN2B-AS1 coronary artery disease N/A N/A N/A expression Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. 19343170 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A expression Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. 19343170 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A mutation Variants (rs1412829, C>T) in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. 19578366 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A mutation Association identified by GWAS. 19578367 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A expression 9p21.3 may promote atherosclerosis by regulating expression of ANRIL, which in turn is associated with altered expression of genes controlling cellular proliferation pathways. 19592466 LncRNADisease
EL0289 CDKN2B-AS1 coronary artery disease N/A N/A N/A expression Whole blood RNA expression of the short variants of ANRIL was increased by 2.2-fold whereas expression of the long ANRIL variant was decreased by 1.2-fold in healthy subjects homozygous for the risk allele. Expression levels of the long and short ANRIL variants were positively correlated with that of the cyclin-dependent kinase inhibitor, CDKN2B (p15) and TDGF1 (Cripto), respectively. 19592466 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation/expression Transcripts EU741058 and NR_003529 of antisense noncoding RNA in the INK4 locus (ANRIL) were significantly increased in carriers of the risk haplotype. 20056914 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A locus We also confirmed prior associations near CDKN2A-CDKN2B locus. 20364137 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A mutation Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. 20386740 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A mutation Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. 20386740 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. 20386740 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 familial and sporadic intracranial aneurysms N/A N/A N/A mutation All 6 index cases from IA families had the rs1333040-T allele (C>T) in CDKN2BAS. 20395613 LncRNADisease
EL0289 CDKN2B-AS1 breast cancer N/A N/A N/A locus A locus associated with breast cancer. 20453838 LncRNADisease
EL0289 CDKN2B-AS1 nasopharyngeal carcinoma N/A N/A N/A mutation A SNP rs1412829 (C49137T) at CDKN2A-CDKN2B gene cluster on 9p21 is associated with this disease. 20512145 LncRNADisease
EL0289 CDKN2B-AS1 endometriosis N/A N/A N/A mutation The authors identified a significant association of endometriosis with rs10965235 (A>C, P = 5.57 x 10(-12), odds ratio = 1.44), which is located in CDKN2BAS on chromosome 9p21, encoding the cyclin-dependent kinase inhibitor 2B antisense RNA.the SNP showing the strongest association was located in intron 16 of CDKN2BAS and was implicated in regulating the expression of p15, p16 and p14. 20601957 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A Interaction ANRIL abundantly expressed in atherosclerotic lesions. ANRIL DQ485454 which is not genetically determined by the 9p21 genotype was significantly correlated with MTAP expression. 20637465 LncRNADisease
EL0289 CDKN2B-AS1 cardiovascular disease N/A N/A N/A mutation Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. 20716961 LncRNADisease
EL0289 CDKN2B-AS1 basal cell carcinoma N/A N/A N/A mutation More recent GWAS also identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for gliomas and basal cell carcinomas in accordance with the princeps observation. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 breast cancer N/A N/A N/A mutation More recently, additional GWAS identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for several cancers including breast cancer, nasopharyngeal carcinoma, basal cell carcinoma, and glioma. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A mutation Common disease genome wide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T) shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A mutation More recent GWAS also identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for gliomas and basal cell carcinomas in accordance with the princeps observation. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A mutation Common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T)shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 nasopharyngeal carcinoma N/A N/A N/A mutation More recently, additional GWAS identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for several cancers including breast cancer, nasopharyngeal carcinoma, basal cell carcinoma, and glioma. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T) shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 basal cell carcinoma N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 breast cancer N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A locus A genetic susceptibility locus 20956613 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 melanoma N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 nasopharyngeal carcinoma N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A locus A genetic susceptibility locus. 20956613 LncRNADisease
EL0289 CDKN2B-AS1 abdominal aortic aneurysm N/A N/A N/A mutation Genetic risk (rs10757278, A>G) for abdominal aortic aneurysm. 21146954 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A Interaction RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. 21151178 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation Individuals homozygous for the atherosclerotic risk allele (rs3217992, A>G;rs1063192, C>T) show decreased expression of ANRIL. 21151960 LncRNADisease
EL0289 CDKN2B-AS1 glaucoma N/A N/A N/A mutation Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 (rs4977756, A>G). 21532571 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A expression Gene expression studies have found that expression levels of CDKN2A/CDKN2B/ANRIL are co-regulated and associated with the risk haplotype and atherosclerosis severity. 21550161 LncRNADisease
EL0289 CDKN2B-AS1 melanoma N/A N/A N/A mutation A large germline deletion (403231 bp) encompassing the INK4/ARF locus and the ANRIL lncRNA has been associated with hereditary cutaneous malignant melanoma (CMM) and neural system tumors (NST) syndrome. 21550244 LncRNADisease
EL0289 CDKN2B-AS1 neural system tumors syndrome N/A N/A N/A mutation A large germline deletion (403231 bp) encompassing the INK4/ARF locus and the ANRIL lncRNA has been associated with hereditary cutaneous malignant melanoma (CMM) and neural system tumors (NST) syndrome. 21550244 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A mutation Variants (rs3217992, A>G;rs1063192, C>T) on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population. 22034006 LncRNADisease
EL0289 CDKN2B-AS1 peripheral artery disease N/A N/A N/A mutation SNP rs2383207 on ANRIL was most significantly associated with lower ABI. 22122968 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation The risk alleles for atherosclerosis-related phenotypes were consistently associated with a lower expression of ANRIL when evaluating exons 1-2. Common carotid artery stenosis was associated with a significantly lower (P<0.01) expression of ANRIL (exons 1-2). ANRIL knock-down in VSMC caused significant variation in expression of CDKN2A/B (P<0.05) and reduction of cell growth (P<0.05) in vitro. 22178423 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A mutation Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders 22814587 LncRNADisease
EL0289 CDKN2B-AS1 plexiform neurofibroma N/A N/A N/A mutation Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders 22814587 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A mutation Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders 22814587 LncRNADisease
EL0289 CDKN2B-AS1 acute lymphoblastic leukemia N/A N/A N/A expression Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate 22817756 LncRNADisease
EL0289 CDKN2B-AS1 melanoma N/A N/A N/A expression Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate 22817756 LncRNADisease
EL0289 CDKN2B-AS1 neuroblastoma N/A N/A N/A expression Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate 22817756 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A expression Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate 22817756 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A expression Genetic variants that affect the expression of the ANRIL transcript have been correlated with stroke risk and recurrence in a large prospective study 22817756 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A mutation Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T4D 22928560 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A mutation Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T2D 22928560 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A mutation Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T3D 22928560 LncRNADisease
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A mutation Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T5D 22928560 LncRNADisease
EL0289 CDKN2B-AS1 leukemia N/A N/A N/A regulation Gene silencing of INK4b-ARF-INK4a and p15/CDKN2B by recruitment of PRC1 and PRC2. 22996375 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A regulation Gene silencing of INK4b-ARF-INK4a and p15/CDKN2B by recruitment of PRC1 and PRC2. 22996375 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A expression ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 cardiovascular disease N/A N/A N/A expression ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 coronary artery disease N/A N/A N/A expression However, overexpression of 1 ANRIL variant altered the expression of many genes involved in nuclear regulation and chromatin architecture, indicating diverse trans-regulatory effects that go beyond the cis-effects seen at 9p21. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 diabetes mellitus N/A N/A N/A expression ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 endometriosis N/A N/A N/A expression ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 glaucoma N/A N/A N/A expression ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions. 23104877 LncRNADisease
EL0289 CDKN2B-AS1 glaucoma N/A N/A N/A mutation CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. 23111177 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A expression ANRIL, also upregulated in prostate cancer, is required for the repression of the tumor suppressors INK4a/p16 and INK4b/p15. 23463798 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A expression Another lncRNA associated with human cancers is ANRIL, a long, antisense transcript found in the INK4a/Arf locus. ANRIL is overexpressed in human leukemias and prostate cancers, and its expression leads to epigenetic silencing of the nearby tumor suppressor p15 (Yu et al., 2008; Yap et al., 2010). 23473599 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A expression Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT1: colorectal cancer). 23660942 LncRNADisease
EL0289 CDKN2B-AS1 Alzheimer's disease N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 diabetes mellitus N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 glaucoma N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 glioma N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 plexiform neurofibroma N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A regulation The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. 23813974 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A regulation The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. 23813974 LncRNADisease
EL0289 CDKN2B-AS1 periodontitis N/A N/A N/A regulation The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. 23813974 LncRNADisease
EL0289 CDKN2B-AS1 atherosclerosis N/A N/A N/A mutation Chr9p21 encodes the long non-coding RNA (ncRNA) antisense non-coding RNA in the INK4 locus (ANRIL). ANRIL expression is associated with the Chr9p21 genotype and correlated with atherosclerosis severity 23861667 LncRNADisease
EL0289 CDKN2B-AS1 cardiovascular disease N/A N/A N/A regulation Recently, ANRIL, a multi-exonic lncRNA, has been shown to be implicated in epigenetic modulation in cardiac development and adult heart and also it has been associated with a locus implicated in cardiovascular disease. 24113581 LncRNADisease
EL0289 CDKN2B-AS1 Stroke N/A N/A N/A expression Levels of CDKN2B-AS1/ANRIL in human carotid atherosclerotic plaques and peripheral blood T lymphocytes are linked to rates of ischemic and hemorrhagic stroke. 24145019 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A regulation ANRIL is an antisense lncRNA elevated in PCa that overlaps this locus, interacting directly with polycomb repressive complex 1 and histone H3K27 methylation to repress CDKN2A-CDKN2B expression 24146262 LncRNADisease
EL0289 CDKN2B-AS1 ischemic stroke N/A N/A N/A regulation Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke. 24385277 LncRNADisease
EL0289 CDKN2B-AS1 cardiovascular disease N/A N/A N/A mutation Aberrant ANRIL transcripts and mutations were associated with cardiovascular disease and cancer . 24531795 LncRNADisease
EL0289 CDKN2B-AS1 cardiovascular disease N/A N/A N/A mutation Aberrant ANRIL transcripts and mutations were associated with cardiovascular disease and cancer . 24531795 LncRNADisease
EL0289 CDKN2B-AS1 hereditary cutaneous malignant melanoma N/A N/A N/A N/A Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). 24624135 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A N/A Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). 24624135 LncRNADisease
EL0289 CDKN2B-AS1 tumor N/A N/A N/A N/A Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). 24624135 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A locus Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. 24624135 LncRNADisease
EL0289 CDKN2B-AS1 coronary disease N/A N/A N/A locus Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. 24624135 LncRNADisease
EL0289 CDKN2B-AS1 intracranial aneurism N/A N/A N/A locus Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. 24624135 LncRNADisease
EL0289 CDKN2B-AS1 type 2 diabetes mellitus N/A N/A N/A locus Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. 24624135 LncRNADisease
EL0289 CDKN2B-AS1 tumor N/A N/A N/A regulation ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators. 24667321 LncRNADisease
EL0289 CDKN2B-AS1 prostate cancer N/A N/A N/A expression ANRIL is upregulated in prostate cancer and is required for the repression of the tumor suppressors INK4a/p16 and INK4b/p15 (Yap et al., 2010; Kotake et al., 2011). 24721780 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A expression High expression of ANRIL has been found in certain cancer tissues such as melanoma and prostate cancers? 24757675 LncRNADisease
EL0289 CDKN2B-AS1 nasopharyngeal carcinoma N/A N/A N/A mutation In recent years, GWAS has identified ANRIL as a risk locus for NPC and other cancers. 24817925 LncRNADisease
EL0289 CDKN2B-AS1 cancer N/A N/A N/A regulation It has also been shown that the tumor suppressor gene p15 is silenced by its natural antisense RNA, a lncRNA ANRIL. 24829860 LncRNADisease
EL0289 CDKN2B-AS1 endometriosis N/A N/A N/A mutation Rs10965235 SNP in the CDKN2B-AS gene was significantly associated with endometriosis in this Korean population. 25154675 LncRNADisease
EL0289 CDKN2B-AS1 breast cancer qPCR etc. breast cancer tissue up-regulated expression Expression of ANRIL mainly coclustered with p14/ARF both in physiologic (various normal human tissues) and in pathologic conditions (human breast tumors). 17440112 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 melanoma qPCR etc. melanoma tissue differential expression mutation Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. 20386740 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 glioma qPCR etc. glioma tissue differential expression mutation Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL. 20386740 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 prostate cancer qPCR etc. cell lines (PC3, MEFs, IMR90 etc.) up-regulated Interaction Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues. 20541999 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 cervical cancer qPCR etc. cell line (CaSki) up-regulated expression Down-regulated in cells were incubated in the presence of BLM for 24 h or irradiated. 22487937 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 laryngeal squamous cell carcinoma qPCR etc. LSCC tissue up-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
EL0289 CDKN2B-AS1 acute lymphoblastic leukemia qPCR, knockdown etc. cell lines (KG-1, Kasumi-1) up-regulated N/A We found an inverse relation between p15 antisense (p15AS) and p15 sense expression in leukaemia. A p15AS expression construct induced p15 silencing in cis and in trans through heterochromatin formation but not DNA methylation; the silencing persisted after p15AS was turned off, although methylation and heterochromatin inhibitors reversed this process. Moreover, 11 out of 16 patient samples (69%) showed relatively increased expression of p15AS and downregulated p15 expression (6/11 in acute myeloid leukaemia and 5/5 in acute lymphoblastic leukaemia). In contrast, 16 normal controls showed high expression of p15 but relatively low expression of the p15AS. Additionally, the two acute myeloid leukaemia lines, which displayed high p15AS and low p15 expression. 18185590 Lnc2Cancer
EL0289 CDKN2B-AS1 acute myeloid leukemia qPCR, knockdown etc. cell lines (KG-1, Kasumi-1) up-regulated N/A We found an inverse relation between p15 antisense (p15AS) and p15 sense expression in leukaemia. A p15AS expression construct induced p16 silencing in cis and in trans through heterochromatin formation but not DNA methylation; the silencing persisted aftp15AS was turned off, although methylation and heterochromatin inhibitors reversed this process. Moreover, 11 out of 16 patient samples (69%) showed relatively increased expression of p15AS and downregulated p15 expression (6/11 in acute myeloid leukaemia and 5/5 in acute lymphoblastic leukaemia). In contrast, 16 normal controls showed high expression of p15 but relatively low expression of the p15AS. Additionally, the two acute myeloid leukaemia lines, which displayed high p15AS and low p15 expression.on. 18185590 Lnc2Cancer
EL0289 CDKN2B-AS1 hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines ((HepG2 etc.) up-regulated expression LncRNA ANRIL expression in HCC tissues was significantly higher than in the adjacent non-tumor tissues (P < 0.05). The expression of lncRNA ANRIL was remarkably associated with the histologic grade and TNM stage of HCC patients (P < 0.05). In addition, HCC patients with higher lncRNA ANRIL expression had significantly poorer overall survival (P < 0.05).Moreover, in vitro assays revealed that the decreased expression of lncRNA ANRIL could suppress the cell proliferation, migration and invasion HCC cells. 26045820 Lnc2Cancer
EL0289 CDKN2B-AS1 cervical cancer qPCR, knockdown etc. cell lines (HeLa) up-regulated interaction qRT-PCR showed that ANRIL is highly expressed in these cancer cells compared to normal fibroblasts. Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. 26408699 Lnc2Cancer
EL0289 CDKN2B-AS1 non-small cell lung cancer qPCR, knockdown etc. cell lines (ABC-1, H1299) up-regulated expression qRT-PCR showed that ANRIL is highly expressed in these cancer cells compared to normal fibroblasts. Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. 26408699 Lnc2Cancer
EL0289 CDKN2B-AS1 osteosarcoma qPCR, knockdown etc. cell lines (Saos-2) up-regulated expression qRT-PCR showed that ANRIL is highly expressed in these cancer cells compared to normal fibroblasts. Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. 26408699 Lnc2Cancer
EL0289 CDKN2B-AS1 non-small cell lung cancer qPCR, Western blot etc. NSCLC tissue, cell lines (PC9, SPC-A1, NCI-H1975, H1299, H358) up-regulated expression In this study, we reported that ANRIL expression was increased in NSCLC tissues and Its expression level was significantly correlated with TNM stages and tumor size. Moreover, patients with high levels of ANRIL expression had a relatively poor prognosis. In addition, taking advantage of loss of function experiments in NSCLC cells, we found that knockdown of ANRIL expression could impair cell proliferation and induce cell apoptosis both in vitro and vivo. 25504755 Lnc2Cancer
EL0289 CDKN2B-AS1 bladder cancer qPCR, Western blot etc. bladder cancer specimens and the corresponding adjacent non-tumor tissues up-regulated interaction Our results showed up-regulation of ANRIL in bladder cancer tissues versus the corresponding adjacent non-tumor tissues. Knockdown of ANRIL repressed cell proliferation and increased cell apoptosis, along with decreased expression of Bcl-2 and increased expressions of Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP. 26449463 Lnc2Cancer
EL0289 CDKN2B-AS1 esophageal squamous cell carcinoma qPCR, Western blot, knockdown etc. ESCC tissue, cell lines (TE1, ECA109) up-regulated regulation ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma. 24747824 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 serous ovarian cancer qPCR, Western blot, knockdown etc. SOC tissue, cell lines (SK-OV-3, HO8910) up-regulated interaction We found that ANRIL levels were elevated in SOC tissues compared with normal controls and were highly correlated with advanced FIGO stage, high histological grade, lymph node metastasis, and poor prognosis. Functional studies suggest a critical role of ANRIL in the control of SOC cell migration/invasion at least in part through regulation of MET and MMP3. 25845387 Lnc2Cancer
EL0289 CDKN2B-AS1 gastric cancer qPCR, Western blot, knockdown, RIP etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803) up-regulated regulation Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. 24810364 LncRNADisease Lnc2Cancer
EL0289 CDKN2B-AS1 hepatocelluar carcinoma qPCR, Western blot, knockdown, RIP etc. HCC tissue, cell lines (HepG2, Hep3B, MHCC-97H) up-regulated interaction ANRIL expression was up-regulated in HCC tissues, and the higher expression of ANRIL was significantly correlated with tumor size and Barcelona Clinic Liver Cancer (BCLC) stage. Moreover, taking advantage of loss of function experiments in HCC cells, we found that knockdown of ANRIL expression could impair cell proliferation and invasion and induce cell apoptosis both in vitro and in vivo. 25966845 Lnc2Cancer
EL0289 CDKN2B-AS1 non-small cell lung cancer qRT-PCR 87 NSCLC tissues and three lung cancer cell lines up-regulated expression The expression level of lncRNA ANRIL was higher in NSCLC tissues and lung cancer cells than in adjacent non-tumor tissues and normal human bronchial epithelial cells. Higher expression of lncRNA ANRIL in NSCLC tissues was associated with higher TNM stage and advanced lymph node metastasis. Our results suggested that lncRNA ANRIL was a potential biomarker for NSCLC prognosis. 25889788
EL0289 CDKN2B-AS1 non-small-cell lung cancer qRT-PCR patients suffering from non-small-cell lung cancer (NSCLC) up-regulated expression N/A 26448925
EL0289 CDKN2B-AS1 invasive breast carcinomas qRT-PCR and immunohistochemistry (IHC) invasive breast carcinomas N/A N/A N/A 27102007
EL0289 CDKN2B-AS1 gastric cancer silencing ; qRT-PCR and western blotting gastric cancer tissues of cisplatin-resistant and 5-fluorouracil (5-FU)-resistant patients up-regulated N/A ANRIL positively correlated with the expression in gastic cell; silencing ANRIL decreased the IC50 values in gastric cancer cells 27121324
EL0291 CECR3 cat eye syndrome N/A N/A N/A N/A Cat eye syndrome chromosome region, candidate 3 11381032 LncRNADisease
EL0292 CECR9 cat eye syndrome N/A N/A N/A N/A Cat eye syndrome chromosome region, candidate 9 11381032 LncRNADisease
EL0293 ceruloplasmin ovarian cancer knockdown orthotopic mouse model of ovarian cancer up-regulated interaction NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells. In an orthotopic mouse model of ovarian cancer, siNRCP delivered via a liposomal carrier significantly reduced tumor growth compared with control treatment. 26686630
EL0294 CES1P1 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL0295 CHL1-AS2 adolescent idiopathic scoliosis N/A N/A N/A mutation We found strongest evidence of association with chromosome 3p26.3 SNPs (rs1400180,A>C) in the proximity of the CHL1 gene (P < 8*10^(-8) for rs1400180). 21216876 LncRNADisease
EL0296 CHRF cardiac hypertrophy N/A N/A N/A regulation The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489. 24557880 LncRNADisease
EL0298 COL3A1 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue up-regulated N/A LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. 25765901 LncRNADisease Lnc2Cancer
EL0301 CPS1-IT1 intrahepatic cholangiocarcinoma qPCR, Western blot, knockdown, Flow cytometry assay etc. ICC tissue, cell line(L-02, Huh-7, Bel-7402) up-regulated interaction Carbamoyl-phosphate synthase 1 (CPS1) and its lncRNA CPS1 intronic transcript 1 (CPS1-IT1) were observed to be upregulated in ICC. CPS1 and CPS1-IT1 were co-upregulated in ICC tissues compared with non-cancerous tissues. Knockdown of CPS1 andor CPS1-IT1 reduced the proliferation and increased the apoptosis of ICC-9810 cells. Additionally, clinical analysis indicated that CPS1 and CPS1-IT1 were associated with poor liver function and reduced survival rates when the relative expression values were greater than 4 in cancer tissues. 26499888 Lnc2Cancer
EL0302 CR613944 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) down-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL0303 CR619813 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) down-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL0305 CRNDE colorectal cancer microarray, qPCR, knockdown etc. cell lines (HCT116, HT29, LS174T etc.) up-regulated N/A In colorectal cancer cells, we demonstrate that treatment with insulin and insulin-like growth factors (IGF) repressed CRNDE nuclear transcripts, including those encompassing gVC-In4. These repressive effects were negated by use of inhibitors against either the PI3K/Akt/mTOR pathway or Raf/MAPK pathway, suggesting CRNDE is a downstream target of both signaling cascades. 24184209 Lnc2Cancer
EL0305 CRNDE colorectal cancer qPCR etc. CRC tissue up-regulated expression An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia. 22393467 LncRNADisease Lnc2Cancer
EL0305 CRNDE glioma qPCR, Western blot, ChIP, Flow cytometry assay etc. glioma tissue, cell lines(U87MG, U251) up-regulated expression Overexpression of specific CRNDE transcript promotes cell growth and migration in vitro while knockdown of CRNDE expression manifests a repressive function during these cellular processes. Mechanistic studies further revealed that histone acetylation in the promoter region might account for the upregulation of CRNDE, and the level of CRNDE expression could be modulated by mammalian Target of Rapamycin (mTOR) signaling in glioma. 25813405 Lnc2Cancer
EL0305 CRNDE colorectal cancer quantitative real-time 142 CRC tissues and 142 paired adjacent nontumorous tissues up-regulated N/A upregulation of lncRNA CRNDE-h was significantly correlated with large tumor size 27042112
EL0307 AC130456.2 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0308 CTB-167B5.2 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated expression We found that the expression of 7 lncRNAs in preneoplastic lesions and HCC was significantly different. 26540467 Lnc2Cancer
EL0309 AC021078.1 prostate cancer integrating analysis of sequence features and gene expression profiles prostate cancer N/A N/A The tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. 26975529
EL0310 CTBP1-AS prostate cancer N/A N/A N/A regulation Oncogene 24373479 LncRNADisease
EL0310 CTBP1-AS prostate cancer N/A N/A N/A regulation The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. 24531795 LncRNADisease
EL0310 CTBP1-AS polycystic ovary syndrome N/A N/A N/A N/A C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. Expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). 25552498 LncRNADisease
EL0310 CTBP1-AS prostate cancer qPCR, Western bolt, Northern bolt, RIP etc. prostate cancer tissue, cell lines (VCaP, LNCaP, DU145, RWPE etc.) up-regulated N/A CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumour growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumour-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression. 23644382 Lnc2Cancer
EL0310 CTBP1-AS hepatocellular carcinoma RT-qPCR serum N/A N/A high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients 27113935
EL0310 CTBP1-AS chronic hepatitis C RT-qPCR serum N/A N/A high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients 27113935
EL0311 CTD-3080P12.3 gastric cancer microarray, qPCR, Western blot, Luciferase reporter assay etc. gastric cancer tissue, cell lines (KATO-III, SGC-7901, MKN28, AGS, MKN45) up-regulated interaction Here, we report that BC032469, a novel lncRNA, expressed highly in gastric cancer tissues, and the upregulation was clinically associated with larger tumor size, poor differentiation and shorter survival of gastric cancer patients. Mechanistically, BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. Thus, BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, suggesting that it may be clinically valuable as a poor prognostic biomarker of gastric cancer. 26549025 Lnc2Cancer
EL0312 CTD903 metastatic colorectal cancer silencing or overexpression of CTD903 in CRC cell lines CRC cell lines up-regulated N/A CTD903 acts as a tumor suppressor in CRC and can inhibit cell invasion and migration through repressing Wnt/β-catenin signalin 27035092
EL0320 CYP2C91 obesity Weighted Gene Co-expression Network Analysis (WGCNA) N/A N/A expression In the current exploratory analysis, we show how a lncRNA - cyp2c91 contributes to the transcriptional regulation localized to cytoplasm thereby making refractory environment for transcription. 26284111
EL0320 CYP2C91 systemic lupus erythematosus Weighted Gene Co-expression Network Analysis (WGCNA) N/A N/A expression In the current exploratory analysis, we show how a lncRNA - cyp2c91 contributes to the transcriptional regulation localized to cytoplasm thereby making refractory environment for transcription. 26284111
EL0322 Cyp4b1-ps2 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 29 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0323 CYP51A1-AS1 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A We chose the lncRNAs AK096725 (upregulated) and ENST00000453068 (downregulated) to confirm their differential expression levels in 70 paired RCC tissues and adjacent non-tumor tissues. Levels of AK096725 were significantly greater in RCC tissues while those of ENST00000453068 was significantly lower compared to the non-tumor tissues. These results are consistent with the microarray data. 24905231 Lnc2Cancer
EL0325 CYTOR gastric cancer microarray, qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) up-regulated expression Linc00152 was validated to be increased in 59 paired gastric cancer specimens (Fig. 3C), and the high levels of Linc00152 expression correlated with larger tumor size. 26237576 Lnc2Cancer
EL0325 CYTOR hepatocelluar carcinoma microarray, qPCR, Western blot, Luciferase reporter assay etc. HCC tissue, cell lines ( HepG2, Hep3B, SNU-423 cells. Huh7, L02, SMMC-7721, MHCC-97H) up-regulated interaction Here, based on the increased level of LINC00152 in HCC tissues, we found that LINC00152 could promote cell proliferation in vitro and tumor growth in vivo. Furthermore, microarray-based analysis indicated that LINC00152 could activate the mechanistic target of rapamycin(mTOR) pathway by binding to the promoter of EpCAM through a cis-regulation, as confirmed by Gal4-N/BoxB reporter system. 26540343 Lnc2Cancer
EL0325 CYTOR gastric cancer qPCR etc. blood(serum) up-regulated expression The levels of plasma LINC00152 were significantly elevated in gastric cancer patients compared with healthy controls. The sensitivity and specificity of plasma LINC00152 in the diagnosis of gastric cancer were 48.1 and 85.2 %, respetcively. LINC00152 levels in preoperative plasma samples were lower than those in postoperative ones. 25391424 Lnc2Cancer
EL0325 CYTOR hepatocelluar carcinoma qPCR etc. blood (plasma), HCC tissue up-regulated expression Circulating HULC and Linc00152 were significantly up-regulated in plasma samples of HCC patients during training set and validation set. 26356260 Lnc2Cancer
EL0325 CYTOR gastric cancer qPCR, Western blot, ISH, RIP, RNA pull-down assay etc. gastric cancer tissue, cell lines (MGC803, HGC-27) up-regulated interaction In this study, we first confirmed the upregulation of cytoplasmic expressed Linc00152 in 72 pair tissues of gastric patients. A suppression of cell proliferation and tumor growth was obtained in MGC803 and HGC-27 cells treated with Linc00152 shRNA. RNA pull-down and RIP assay revealed that Linc00152 could directly bind with EGFR which caused an activation of PI3K/AKT signaling. 26538117 Lnc2Cancer
EL0325 CYTOR pancreatic cancer qPCR, Western blot, knockdown etc. PDAC tissue up-regulated expression The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR. 25910082 Lnc2Cancer
EL0325 CYTOR gastric cancer qPCR, Western blot, Northern blot, knockdown etc. gastric cancer tissue, cell lines (AGS, BGC-823, MGC-803, SGC-7901 etc.) up-regulated N/A The results showed that the expression level of LINC00152 in gastric carcinoma was significantly increased, compared with matched normal tissue (P=0.045) and normal mucosa from health control (P=0.004), respectively. Levels of LINC00152 in gastric cancer cell lines, BGC-823, MGC-803, and SGC-7901, were significantly higher than those in human normal gastric epithelial cell line GES-1. In addition, high expression of LINC00152 was correlated with invasion (P=0.042). LINC00152 levels in gastric juice from patients with gastric cancer were further found significantly higher than those from normal controls (P=0.002). 24523021 Lnc2Cancer
EL0327 DACOR1 colon cancer RNA-seq, qPCR, ChIRP-seq, Western blot, RIP etc. colon cancer tissue, cell line (HCT116) down-regulated interaction DACOR1 shows high, tissue-specific expression in the normal colon but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. Induction of DACOR1 in colon cancer cell lines significantly reduced their ability to form colonies in vitro, suggesting a growth suppressor function. Induction of DACOR1 led to the activation of tumor-suppressor pathways and attenuation of cancer-associated metabolic pathways. 26307088 Lnc2Cancer
EL0329 DANCR osteosarcoma Lentivirus-mediated (shRNA) to silence osteosarcoma cell lines U2OS and Saos-2 osteosarcoma cell lines U2OS and Saos-2 up-regulated N/A knockdown of ANCR significantly inhibited the proliferation of U2OS and Saos cells and colony formation of U2OS cells 26986815
EL0329 DANCR prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0329 DANCR bone diseases N/A N/A N/A expression These data suggest that ANCR is an essential mediator of osteoblast differentiation, thus offering a new target for the development of therapeutic agents to treat bone diseases. 23438432 LncRNADisease
EL0329 DANCR postmenopausal osteoporosis N/A N/A N/A N/A DANCR promoted the expression of IL6 and TNF-alpha at both mRNA level and protein level in MNCs. DANCR level was correlated with IL6 and TNF-alpha in postmenopausal women with low BMD 25660720 LncRNADisease
EL0329 DANCR hepatocelluar carcinoma qPCR etc. HCC cell lines up-regulated interaction We found that lncRNA-DANCR is over-expressed in stem-like HCC cells and this can serve as a prognostic biomarker for HCC patients. Experiments showed that DANCR markedly increased stemness features of HCC cells to promote tumorigenesis and intra-/extra-hepatic tumor colonization.Our studies reveal a significance and mechanism of DANCR action in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HCC. 25964079 Lnc2Cancer
EL0329 DANCR colorectal cancer qPCR etc. colorectal cancer tissues and paired adjacent non-tumor tissues up-regulated expression Our results showed that lncRNA DANCR expression was increased in CRC tissues compared with that in adjacent normal tissues (P<0.05). In addition, tumors with high lncRNA DANCR expression was correlated with TNM stage, histologic grade, and lymph node metastasis (P<0.05). Kaplan-Meier analysis showed that patients with high lncRNA DANCR expression had a shorter overall survival (OS) and disease-free survival (DFS) compared with the low lncRNA DANCR expression group (P<0.05). Moreover, in a multivariate Cox model, our results showed that lncRNA DANCR expression was an independent poor prognostic factor for both OS and DFS in CRC. 26617879 Lnc2Cancer
EL0330 DAOA-AS1 bipolar disorder N/A N/A N/A mutation Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. 12647258 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A expression Markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population. 15194506 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A N/A Association with schizophrenia. 15271585 LncRNADisease
EL0330 DAOA-AS1 panic disorder N/A N/A N/A N/A Panic disorder associated. 15477870 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A N/A G72/G30 (DAOA-AS1) are important candidate genes for explaining schizophrenia in the Han Chinese population. 15653269 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A N/A G72/G30 genes are involved in conferring susceptibility to schizophrenia. 16402132 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A mutation Transmission disequilibrium analysis revealed a significant association between the rs947267 polymorphism (A>C) and schizophrenia (P=0.016), with the A allele more commonly transmitted to patients. 16791105 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A mutation Meta-analysis revealed that there is weak evidence of association between the G72/G30 genes and schizophrenia. 17179078 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A mutation Significant associations of schizophrenia with the A allele of rs947267 (A>C,P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients. 17179866 LncRNADisease
EL0330 DAOA-AS1 schizophrenia N/A N/A N/A mutation rs778294 (A>G) and rs947267 (A>C), were found to be associated with the risk of schizophrenia. 17651942 LncRNADisease
EL0331 DAPK1 pancreatic ductal adenocarcinoma microarray, qPCR etc. cell line (MIA PaCa-2 ) up-regulated expression Differential expression 22078386 LncRNADisease Lnc2Cancer
EL0332 DBET Facioscapulohumeral muscular dystrophy Gene expression study in human cells to build pathways involved by DBE-T in FSHD patients N/A N/A N/A DBE-T, a chromatin-associated noncoding RNA produced selectively in FSHD patients that coordinates de-repression of 4q35 genes. DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. 22541069
EL0332 DBET Facioscapulohumeral muscular dystrophy N/A N/A N/A mutation The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy. 22710800 LncRNADisease
EL0332 DBET Facioscapulohumeral muscular dystrophy N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0332 DBET Facioscapulohumeral muscular dystrophy N/A N/A N/A regulation In contrast, in FSHD patients, a deletion of D4Z4 repeats results in cis production of the DBE-T lncRNA that binds to protein complexes, reorganizes the chromatin state of the FSHD locus, and reactivates the repressed 4q35 genes. 24667321 LncRNADisease
EL0332 DBET Facioscapulohumeral muscular dystrophy N/A N/A N/A expression As a result, this region becomes more prone to transcription and gives rise to the activatory lncRNA DBE-T. DBE-T is mainly produced in FSHD patients and mediates the aberrant activation of the FSHD locus. 24685002 LncRNADisease
EL0333 DBH-AS1 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. HCC tissue, cell lines (HepG2, SMMC-7721, Hep3B, MHCC97H, SK-Hep1) up-regulated interaction The levels of DBH-AS1 were positively correlated with hepatitis B surface antigen (HBsAg) and tumor size in HCC tissues. Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. We also provide evidence that DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. Thus, we concluded that DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in HCC. 26393879 Lnc2Cancer
EL0334 DDR2 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL0335 DDX6P1 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) down-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL0336 DGCR5 clear cell renal cell carcinoma microarray, qPCR etc. renal clear cell carcinoma tissue up-regulated N/A ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). 22879955 Lnc2Cancer
EL0336 DGCR5 DiGeorge syndrome N/A N/A N/A expression The DiGeorge syndrome-associated noncoding RNA, DGCR5, is repressed by REST through a proximal upstream binding site. 19050060 LncRNADisease
EL0336 DGCR5 velocardiofacial syndrome N/A N/A N/A N/A Association 20380817 LncRNADisease
EL0336 DGCR5 Huntington's disease N/A N/A N/A expression Interestingly, many of these lncRNAs contain genomic binding sites for the transcriptional repressor REST, a key mediator of transcriptional changes in HD, including the known REST target lncRNA, DGCR5. 23346095 LncRNADisease
EL0336 DGCR5 DiGeorge syndrome N/A N/A N/A mutation DGCR5 is disrupted by the patient ADU breakpoint. 8659529 LncRNADisease
EL0341 DISC2 Autism spectrum disorder N/A N/A N/A regulation DISC1 is regulated by its lncRNA, DISC6, which may also represent an excellent candidate for susceptibility to these disorders. 22817756 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A locus DISC2 should be considered a formal candidate gene for susceptibility to psychiatric illness (schizophrenia). 10814723 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A mutation The Disrupted in Schizophrenia (DISC) locus on human chromosome 1q42 has been strongly implicated by genetic studies as a susceptibility locus for major mental illnesses.DISC2, a putative noncoding transcript partially antisense to DISC1, is not conserved. 12573262 LncRNADisease
EL0341 DISC2 affective disorders N/A N/A N/A N/A DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. 15478311 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A N/A DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. 15478311 LncRNADisease
EL0341 DISC2 bipolar disorder N/A N/A N/A locus The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. 17912248 LncRNADisease
EL0341 DISC2 depression N/A N/A N/A locus The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. 17912248 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A locus The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. 17912248 LncRNADisease
EL0341 DISC2 Autism spectrum disorder N/A N/A N/A locus The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. 19606485 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A locus The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders. 20380817 LncRNADisease
EL0341 DISC2 bipolar disorder N/A N/A N/A regulation DISC1 is regulated by its lncRNA, DISC4, which may also represent an excellent candidate for susceptibility to these disorders. 22817756 LncRNADisease
EL0341 DISC2 major depression N/A N/A N/A regulation DISC1 is regulated by its lncRNA, DISC5, which may also represent an excellent candidate for susceptibility to these disorders. 22817756 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A regulation DISC1 is regulated by its lncRNA, DISC3, which may also represent an excellent candidate for susceptibility to these disorders. 22817756 LncRNADisease
EL0341 DISC2 Autism spectrum disorder N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0341 DISC2 bipolar disorder N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0341 DISC2 major depression N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0341 DISC2 schizophrenia N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0342 DKFZP434K028 gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) down-regulated expression Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. 26237576 Lnc2Cancer
EL0343 DLEU1 B cell chronic lymphocytic leukemia a combination of genomic and cDNA library screening, RT-PCR, Northern blotting N/A N/A N/A As no mutations have been detected for leu1 or any other transcript so far described, we cannot exclude the existence of control elements within the rmd that may regulate expression of genes lying in this region. 12094250
EL0343 DLEU1 chronic lymphocytic leukemia chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) CLL cells N/A N/A the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA 23593011
EL0343 DLEU1 multiple myeloma FISH myeloma cases N/A locus A cdr of approximately 350 kb was identified at 13q14 with the proximal border approximately 120 kb centromeric from d13s319, encompassing an area rich in expressed sequence tagged sites and containing dleu1, dleu2, and rfp2 genes. 12461754
EL0343 DLEU1 breast cancer microarray, qRT-PCR MCF-7 (ER-positive) and MDA-MB-231 cells (ER- negative) up-regulated interaction MiR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1, which influences the occurrence and development of breast cancer cells with different levels of ER expression. 26416600
EL0343 DLEU1 head and neck squamous-cell carcinoma microsatellite repeat polymorphisms and PCR N/A N/A locus Multiplexed pcr revealed homozygous deletion of leu1 in one oral cavity tumor. 10684931
EL0343 DLEU1 B-cell chronic lymphocytic leukemia N/A N/A N/A expression Sequence analysis of the rna variants suggests that bcms transcripts belong to the group of non-coding rnas. 11406609
EL0343 DLEU1 B-cell chronic lymphocytic leukemia N/A N/A N/A expression Since their putative involvement in b-cll was controversial, our present study provide support for reconsidering the dleu1 and dleu2 genes as b-cll candidate genes 11691637
EL0343 DLEU1 inherited bone marrow failure disorder oligonucleotide microarray N/A up-regulated expression several oncogenes were found to be upregulated, including LARG, TAL1 and MLL, and of several tumour suppressor genes were downregulated, including DLEU1, RUNX1, FANCD2 and DKC1. Real time polymerase chain reaction confirmed statistically higher expression of LARG and TAL1 in SDS marrows. 17539775
EL0343 DLEU1 chronic lymphocytic leukemia qPCR etc. blood differential expression locus In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. 19347735 LncRNADisease Lnc2Cancer
EL0343 DLEU1 chronic lymphocytic leukemia qPCR, FISH etc. blood down-regulated mutation Frequently deleted in B-cell chronic lymphocytic leukemia. 11161783 LncRNADisease Lnc2Cancer
EL0343 DLEU1 chronic lymphocytic leukemia qPCR, FISH etc. blood differential expression N/A Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. 9395242 LncRNADisease Lnc2Cancer
EL0344 DLEU2 chronic lymphocytic leukemia chromatin immunoprecipitation assay, small interfering RNA-mediated repression CLL patients, Human Burkitt’s lymphoma cell line Daudi down-regulated N/A The transcription factor BSAP (B-cell-specific activator protein) directly interacts with Dleu2, the host gene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in repression of miR-15a/16-1 expression. 23995789
EL0344 DLEU2 chronic lymphocytic leukemia chromatin-immunoprecipitation (ChIP) that are associated with activated transcription; semi-quantitative and quantitative methods (aPRIMES, BioCOBRA, MCIp, MassARRAY, and bisulfite sequencing) CLL cells N/A N/A the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA 23593011
EL0344 DLEU2 multiple myeloma FISH myeloma cases N/A locus A cdr of approximately 350 kb was identified at 13q14 with the proximal border approximately 120 kb centromeric from d13s319, encompassing an area rich in expressed sequence tagged sites and containing dleu1, dleu2, and rfp2 genes. 12461754
EL0344 DLEU2 B-cell chronic lymphocytic leukemia N/A N/A N/A mutation B-cell chronic lymphocytic leukemia: frequent chromosomal imbalance. 11072235 LncRNADisease
EL0344 DLEU2 mantle-cell lymphoma N/A N/A N/A mutation mantle-cell lymphoma: frequent chromosomal imbalance. 11072235 LncRNADisease
EL0344 DLEU2 B-cell chronic lymphocytic leukemia N/A N/A N/A N/A No expression of 1b4/leu2 was detectable in b-cll, regardless of the 13q14 status. these results indicate that allelic loss and mutation of a gene within the mdr is an unlikely pathogenetic mechanism for b-cll. 11264177
EL0344 DLEU2 lymphocytic leukemia N/A N/A N/A locus Dleu2 is an antisense transcript that encompasses the Kcnrg and Trim13 genes, as well as two microRNA genes, Mirn16-1 and Mirn15a, which have been previously identified in lymphocytic leukemia. 18562676 LncRNADisease
EL0344 DLEU2 chronic lymphocytic leukemia N/A N/A N/A N/A DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia 23551855
EL0344 DLEU2 chronic lymphocytic leukemia qPCR etc. blood differential expression locus In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region. 19347735 LncRNADisease Lnc2Cancer
EL0344 DLEU2 chronic lymphocytic leukemia qPCR, FISH etc. blood down-regulated mutation Frequently deleted in B-cell chronic lymphocytic leukemia. 11161783 LncRNADisease Lnc2Cancer
EL0344 DLEU2 chronic lymphocytic leukemia qPCR, FISH etc. blood differential expression N/A Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. 9395242 LncRNADisease Lnc2Cancer
EL0344 DLEU2 myeloma qPCR, Western blot, Northern blot, Luciferase reporter assay etc. myeloma tissue, cell lines (HEK293, U2OS etc.) down-regulated expression The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. 19591824 LncRNADisease Lnc2Cancer
EL0344 DLEU2 chronic lymphocytic leukemia qPCR, Western blot, Northern blot, Luciferase reporter assay etc. blood, cell lines (HEK293, U2OS etc.) down-regulated expression The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. 19591824 LncRNADisease Lnc2Cancer
EL0344 DLEU2 lymphoma qPCR, Western blot, Northern blot, Luciferase reporter assay etc. cell lines (HEK293, U2OS etc.) down-regulated expression The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. 19591824 LncRNADisease Lnc2Cancer
EL0344 DLEU2 non-small cell lung cancer qRT-PCR, Small interfering RNA (siRNA) transfection, Western blotting, ChIP assays Pair-matched tumorous and adjacent nontumorous lung tissues from 27 patients, A549 and H1299 up-regulated N/A Histone deacetylases, HDACs inhibitors trichostatin A (TSA) and sodium butyrate upregulated the expression of miR-15a/16-1, among class Ι HDACs subtypes, only knockdown of HDAC3 by specific siRNA increased the hyperacetylation of Dleu2/miR-15a/16-1 promoter region and finally resulted in the upregulation of miR-15a/16-1.overexpression of miR-15a/16-1, which were always deleted or downregulated in lung cancer cells, effectively suppressed cell growth and reduced colony formation 23867991
EL0346 DLG2-AS1 schizophrenia N/A N/A N/A locus These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors. 13130513 LncRNADisease
EL0346 DLG2-AS1 myotonic dystrophy type 1 N/A N/A N/A mutation The mutant DMPK transcript causes myotonic dystrophy type 1 (DM1), which is encoded by a protein-coding gene containing a CUG expansion repeat in its 3'-untranslated region. 19909263 LncRNADisease
EL0346 DLG2-AS1 heart failure N/A N/A N/A expression it is clear that Nkx2-5 is a genetic modifier of myotonic muscular dystrophy RNA toxicity and indicates important functionality of this 3'UTR, independent of its mRNA, in heart dysfunction. 23104877 LncRNADisease
EL0349 DLX6-AS1 lung adenocarcinoma microarray, qPCR, Western blot etc. lung cancer tissue, cell lines(A549, H1650 etc.) up-regulated expression The expression level of lncRNA DLX6-AS1 in LAC tissues was significantly higher compared to paired adjacent normal lung tissues. In addition, its expression level was closed correlated with both histological differentiation and TNM stage. Down-regulation of lncRNA DLX6-AS1 expression decreased the DLX6 mRNA and protein levels. 26052251 Lnc2Cancer
EL0349 DLX6-AS1 Split Hand/Split Foot malformation disorder N/A N/A N/A Interaction The lncRNA EVF2, which recruits the transcription factor Dlx2 to activate the protein coding genes DLX5 and DLX6 that are associated with the Split Hand/ Split Foot malformation disorder. 20930520 LncRNADisease
EL0352 Dmrt2 cancer N/A N/A N/A regulation In many cancer cells TERRA is downregulated, providing a possible link to the longevity of cancer cells by telomerase-mediated lengthening of chromosomal ends. 23660942 LncRNADisease
EL0353 DMTF1 gastric cancer microarray, qPCR, Western blot etc. cell lines (SGC7901) up-regulated N/A We show here that the lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines. 24958102 Lnc2Cancer
EL0354 DNM3OS epithelial ovarian cancer qPCR etc. cell lines (type I, type II etc.) up-regulated locus pri-miR-199a2 within the human Dnm3os gene. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC (epithelial ovarian cancer) patients. 20400975 LncRNADisease Lnc2Cancer
EL0355 DQ786243 hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue up-regulated N/A AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. 21769904 Lnc2Cancer
EL0355 DQ786243 Crohn's disease N/A N/A N/A regulation LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease. 24289115 LncRNADisease
EL0355 DQ786243 colorectal cancer quantitative real-time polymerase CRC tissues and cell lines up-regulated N/A DQ786243 is an oncogene 26934980
EL0356 DRAIC prostate cancer qPCR, Western blot etc. cell lines (VCap, PC3M-luc, LNCaP etc.) down-regulated N/A The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus. Prostate cancers persisting in patients after androgen deprivation therapy (ADT) select for decreased DRAIC expression, and higher levels of DRAIC in prostate cancer are associated with longer disease-free survival (DFS). DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma, and stomach adenocarcinoma. 25700553 LncRNADisease Lnc2Cancer
EL0357 Dreh hepatocelluar carcinoma microarray, qPCR, in vitro knockdown, RIP etc. HCC tissue down-regulated N/A We identified an lncRNA, down-regulated expression by HBx (termed lncRNA-Dreh), which can inhibit HCC growth and metastasis in vitro and in vivo, act as a tumor suppressor in the development of HBV-HCC. LncRNA-Dreh could combine with the intermediate filament protein vimentin and repress its expression, further change the normal cytoskeleton structure to inhibit tumor metastasis. 23239537 Lnc2Cancer
EL0357 Dreh hepatocelluar carcinoma N/A N/A N/A regulation Further experiments showed that Dreh can specifically bind to vimentin, a type III intermediate filament and the major cytoskeletal component of mesenchymal cells and then inhibit HCC metastasis by modifying the expression and reorganization of vimentin. 24296588 LncRNADisease
EL0357 Dreh hepatocelluar carcinoma N/A N/A N/A regulation lncRNA-Dreh could bind to the intermediate filament protein vimentin, repress its expression, and thus change the cytoskeleton structure and inhibit tumor metastasis. It acts as a tumor suppressor in the development of HBV-HCC, which inhibits HCC growth and metastasis?in vitro?and?in vivo. These findings support a role of lncRNA-Dreh in tumor suppression and survival prediction of HCC patients. 24757675 LncRNADisease
EL0358 DSCAM-AS1 breast cancer cell cultures or fresh tumor biopsies MCF-8 cells in absence of hormones Erα N/A expression Down-regulation of DSCAM-AS1 recapitulated, in part, the effect of silencing ERα, i.e. growth arrest and induction of EMT markers. 26621851
EL0358 DSCAM-AS1 adolescent idiopathic scoliosis N/A N/A N/A mutation Other top associations in our GWAS were with SNPs (rs2222973, C>T) in the DSCAM gene. 21216876 LncRNADisease
EL0358 DSCAM-AS1 breast cancer qPCR, Northern blot, ISH etc. cell lines (MCF-7, T47D, ZR-75-1 etc.) up-regulated expression M41 (DSCAM-AS1) mRNA is expressed at a statistically significantly higher level in human breast cancer specimens than in normal human breast and benign lesions. 12177779 LncRNADisease Lnc2Cancer
EL0361 EBER Epstein-Barr virus isothermal titration calorimetry and gel electrophoresis N/A N/A N/A N/A 16580685
EL0362 EEF1A1P9 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0363 EFNA3 breast cancer qPCR, RIP etc. breast cancer tissue up-regulated N/A We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possibly by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tissue. In agreement, we found a strong correlation between high EFNA3 expression and shorter metastasis-free survival in breast cancer patients. hypoxia could contribute to metastatic spread of breast cancer via HIF-mediated induction ofEFNA3lncRNAs and subsequent Ephrin-A3 protein accumulation. 25023702 Lnc2Cancer
EL0364 EGFLAM-AS1 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC-7901, AGS, BGC-823, HG-27, GES-1) down-regulated interaction Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level. 26537802 Lnc2Cancer
EL0365 EGFR-AS1 hepatocelluar carcinoma microarray, qPCR, Western blot, knockdown, FCA etc. HCC tissue, cell lines of (SMMC-7721, LM-9, Huh-7, HepG2) up-regulated interaction It was verified that EGFR and EGFR-AS1 were relatively upregulated in HCC tissue, and they were significantly related to some clinical characteristics and patient prognosis. Furthermore, EGFR-AS1 was determined to promote HCC development by improving the ability of invasion and proliferation of HCC cells in vitro, and it was also found to affect the cell cycle. Our study identified that EGFR-AS1 may promote HCC genesis and development. EGFR-AS1 may act as a prognostic factor in HCC. 26271667 Lnc2Cancer
EL0366 EGOT prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0366 EGOT breast cancer qPCR etc. breast cancer tissues, down-regulated expression EGOT expression was lower in breast cancer compared with the adjacent noncancerous tissues, and low levels of EGOT expression were significantly correlated with larger tumor size, more lymph node metastasis, and higher Ki-67 expression. Moreover, patients with low levels of EGOT expression showed significantly worse prognosis for overall survival. Multivariate analysis suggested that low levels of EGOT were a poor independent prognostic predictor for breast cancer patients 26159853 Lnc2Cancer
EL0367 EHHADH-AS1 colorectal cancer microarray, qPCR etc. cell line (HCT116) down-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL0368 ELFN1-AS1 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0371 ENO1 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0391 KCP hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0392 TTTY7 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0393 AC079610.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0394 LINC00336 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0395 AL445248.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0396 AC006305.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0397 LINC01020 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0398 FAM66B hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0399 LINC01139 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0400 LINC00323 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0401 LINC01204 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0402 LINC01721 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0403 ENSG00000230544.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0404 ENSG00000231133.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0405 SPRY4-AS1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0406 LEF1-AS1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0407 LINC01798 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0408 ENSG00000232956.3 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0409 LINC01762 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0410 LOC100129434 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0411 SMIM2-IT1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0412 ENSG00000237036.3 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0413 TTLL11-IT1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0414 ENSG00000240453.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0415 AC093620.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0416 ENSG00000245910.3 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0417 AC109349.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0418 LOC101928858 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0419 AC026427.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0420 LOC105377448 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0421 LOC339874 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0422 AL359075.2 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0423 AP001528.2 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0424 AC007848.2 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0425 LINC00929 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0426 LINC00596 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0427 ENSG00000259484.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0428 ENSG00000259758.1 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0429 LINC00667 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0430 AC016876.2 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0431 LINC01538 hereditary haemorrhagic telangiectasia N/A N/A N/A expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. 24603890 LncRNADisease
EL0432 Gm6768 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 28 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0433 ENSMUST00000041159 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 31 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0434 Tdpx-ps1 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 30 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0435 Gm15054 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 15 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0436 Gm12919 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 24 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0437 Gm7327 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 14 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0438 Gm14155 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 8 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0439 Gm14089 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 17 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0440 ENSMUST00000142855 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 6 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0441 Gm13133 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 9 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0442 Gm11827 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL0443 Gm15834 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 23 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0444 ENSMUST00000167632 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 20 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0445 ENST00000318333 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0446 RPL12P1 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0447 ENST00000395084 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL0448 AL353608.3 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL0449 ENST00000414355 cadmium toxicology knockdown 35th Cd-induced cells and untreated 16HBE cells up-regulated interaction SiRNA-mediated knockdown of ENST00000414355 inhibited the growth of DNA-damaged cells and decreased the expressions of DNA-damage related genes (ATM, ATR and ATRIP), while increased the expressions of DNA-repair related genes (DDB1, DDB2, OGG1, ERCC1, MSH2, RAD50, XRCC1 and BARD1). A significant positive correlation was observed between blood ENST00000414355 expression and urinary/blood Cd concentrations, and there were significant correlations of lncRNA-ENST00000414355 expression with the expressions of target genes in the lung of Cd-exposed rats and the blood of Cd exposed workers. 26464647
EL0450 AL355581.1 pediatric acute myeloid leukemia qRT-PCR three bone marrow samples obtained from each pediatric AML patient down-regulated interaction Dysregulated lncRNAs and mRNAs in pediatric AML versus normal controls that could form gene pathways to regulate cell cycle progression and immunoresponse. 26573779
EL0451 POM121L13P gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue down-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0452 LINC01384 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0453 LINC01852 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL0454 ENST00000435885.1 esophageal squamous cell carcinoma microarray, qPCR etc. OSCC tissue differential expression N/A we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. 24522499 Lnc2Cancer
EL0455 ENST00000442037 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL0456 TDGF1P1 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue up-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL0457 ZNRD1ASP endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue down-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL0458 MTCO3P10 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0459 AL133244.1 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0460 AC096915.1 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0461 LINC00887 clear cell renal cell carcinoma microarray, qPCR etc. renal clear cell carcinoma tissue up-regulated N/A ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). 22879955 Lnc2Cancer
EL0462 ENST00000460164 triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
EL0463 AC004893.2 colorectal cancer microarray, qPCR etc. cell line (HCT116) down-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL0464 ENST00000501583 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A To validate the microarray analysis results, five lncRNAs were randomly selected from the differential lncRNAs and their expressions were analyzed using qPCR in 29 pairs of HCC and matched NT tissues. Our data indicated that the expressions of TCONS_00018278, AK093543, D16366 and ENST00000501583 were significantly downregulated in HCC, whereas the expression of NR_002819 showed no significant difference. 24876753 Lnc2Cancer
EL0465 HAND2-AS1 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue down-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL0466 AC012312.1 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue down-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL0467 LINC01096 triple-negative breast cancer microarray, qPCR etc. TNBC tissue down-regulated expression The results demonstrated that lncRNAs NONHSAT125629 and ENST00000503938 were upregulated and that XR_250621.1 and NONHSAT012762 were down-regulated in the tumor samples compared with NT samples. These qPCR results are consistent with the microarray data. 26078338 Lnc2Cancer
EL0468 ENST00000537266 papillary thyroid carcinoma microarrays, CCK-8 assay, colony formation assay and EdU assay, Flow Cytometry, Transwell and scratch assay Papillary thyroid cancer cell line N/A expression lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. lncRNAs (ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis. 26824456
EL0469 AC022075.3 colorectal cancer microarray, qPCR etc. cell line (HCT116) down-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL0470 AC026369.2 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL0471 LINC02446 colorectal cancer microarray, qPCR etc. cell line (HCT116) down-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL0472 ENST00000545440 astrocytoma lncRNA microarray, qRT-PCR, astrocytoma samples up-regulated expression The upregulation of ENST00000545440 and NR_002809 was associated with advanced clinical stages of astrocytoma. 26252651
EL0473 LINC01234 esophageal squamous cell carcinoma microarray, qPCR etc. OSCC tissue differential expression N/A we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. 24522499 Lnc2Cancer
EL0474 LINC02086 colorectal cancer microarray, qPCR etc. cell line (HCT116) down-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL0475 EPB41L4A-AS1 cancer N/A N/A N/A expression Ectopic expression of TIGA1 (EPB41L4A-AS1) inhibited not only tumor cell proliferation but also anchorage-independent growth of cancer cell lines. 16973895 LncRNADisease
EL0476 EPB41L4A-AS2 breast cancer evaluated its relationship with the clinicopathological features breast cancer tissues up-regulated N/A processes associated with tumor biology 26980733
EL0477 EPOR gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue down-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0478 ERCC1 gastric cancer qPCR etc. gastric cancer tissues, cell lines (AGS, SGC-7901, BGC-823, HG27) down-regulated expression The results showed that the expression level of AC138128.1 in GC was significantly decreased compared to that in NAT. Levels of AC138128.1 in the GC cell lines, AGS BGC-823, HG27, and SGC-7901 were lower than those in the human normal gastric epithelial cell line GES-1. lncRNA AC138128.1 might be a novel biomarker for predicting GC. 25260808 Lnc2Cancer
EL0479 ERICD retinoblastoma activation / knockdown of either E2F1 or E2F3 N/A down-regulated N/A ERIC is transcriptionally regulated by E2Fs, and restricts apoptosis induced by E2F1, as well as by DNA damage. 24168400
EL0480 DLGAP2 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression We discovered that three lncRNAs (RP11-397D12.4, AC007403.1, and ERICH1-AS1) were up regulated in NSCLC, compared with cancer-free controls. RP11-397D12.4, AC007403.1, and ERICH1-AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future. 26393913 Lnc2Cancer
EL0481 ESCCAL-5 esophageal squamous cell carcinoma microarray, qPCR etc. ESCC tissue up-regulated expression In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5. 24222893 LncRNADisease Lnc2Cancer
EL0482 ESRG intracranial aneurism N/A N/A N/A expression HESRG was expressed strongly and diffusively in the nuclei of tumor cells in intracranial germinoma and embryonal carcinoma as well as in human embryonic stem cells.In germinomas, 25 of 31 showed intensive (3+) expression, four cases showed moderate (2+) immunostaining and the remaining 2 cases showed weak (1+) immunostaining. 21861197 LncRNADisease Lnc2Cancer
EL0482 ESRG embryonal carcinoma qPCR etc. central nervous system tumor tissue, cell lines (H1, H9) up-regulated expression HESRG was expressed strongly and diffusively in the nuclei of tumor cells in intracranial germinoma and embryonal carcinoma as well as in human embryonic stem cells.In embryonal carcinoma, 6 of 9 showed intensive (3+) immunostaining and 3 of 9 showed moderate (2+) immunostaining. 21861197 LncRNADisease Lnc2Cancer
EL0483 EVADR colon, rectal, lung, pancreas and stomach adenocarcinomas RNA-seq, qRT-PCR colorectal tumors up-regulated expression Moderate to high levels of EVADR were detected in 25 to 53% of colon, rectal, lung, pancreas and stomach adenocarcinomas (mean=30 to 144 FPKM), and EVADR expression correlated with decreased patient survival (Cox regression; hazard ratio=1.47, 95% confidence interval=1.06 to 2.04, P=0.02). 25821520
EL0484 EWSAT1 Ewing sarcoma microarray, qPCR, Western blot, RIP etc. cell lines (pMPCs, PSS090 and TC71) up-regulated regulation Expression of EWS-FLI1 and EWSAT1 repressed gene expression, and a substantial fraction of targets that were repressed by EWS-FLI1 were also repressed by EWSAT1. Analysis of RNAseq data from primary human Ewing sarcoma further supported a role for EWSAT1 in mediating gene repression. We identified heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 and found a marked overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1, suggesting that HNRNPK participates in EWSAT1-mediated gene repression. 25401475 Lnc2Cancer
EL0485 FADS1 lipid metabolism disorder N/A N/A N/A regulation The expression of FADS, and its lncRNA, reverse D5-desaturase, were found to be reciprocally regulated by the dietary fat content in animal models 22817756 LncRNADisease
EL0486 FALEC ovarian cancer knockdown ovarian cancer cell lines up-regulated expression These results demonstrate the utility of this integrated approach to identify oncogenic lncRNAs and suggest that FAL1 may represent a prognostic biomarker and therapeutic target in ovarian cancer. FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21. 25367941
EL0486 FALEC ovarian cancer qPCR N/A N/A interaction FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1- specific siRNAs significantly inhibit tumor growth in vivo. 25203321
EL0486 FALEC papillary thyroid carcinoma qRT-PCR PTC and normal thyroid tissues up-regulated N/A FAL1 expression was significantly higher in PTC 26825907
EL0487 FAM30A gallbladder cancer qPCR etc. GBC cell sublines(GBC-SD, GBC-SD/M) up-regulated interaction We found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression of β-catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. 26448925 Lnc2Cancer
EL0488 FAM3D-AS1 tongue cancer RNA-seq, qPCR etc. cell lines (UMSCC-10B, HN-12) down-regulated N/A We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. 25904139 LncRNADisease Lnc2Cancer
EL0488 FAM3D-AS1 pharyngeal cancer RNA-seq, qPCR etc. cell lines (HN-1, HN-30) down-regulated N/A Overexpression of lnc-KCTD6-3 reduced the expression of NANOG 25904139 LncRNADisease Lnc2Cancer
EL0488 FAM3D-AS1 laryngeal cancer RNA-seq, qPCR etc. cell lines (UMSCC-22B) down-regulated N/A Ectopic expression of lnc-LCE5A-1 increased the expression of CDH-1 in HNSCC cells, while decreasing the expression of OCT-4, NANOG, and VIM. 25904139 LncRNADisease Lnc2Cancer
EL0489 FAM83A-AS1 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL0490 FAR2P1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression RP11-133F8.2 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly higher than wild-type EGFR tissues, while LOC440905 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly lower than wild-type EGFR tissues. RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. 25085781 Lnc2Cancer
EL0490 FAR2P1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL0491 FAS-AS1 ataxia telangiectasia N/A human T lymphocytes from patient with ataxia telangiectasia (AT) up-regulated expression FAS-AS1 was up-regulated up to fivefold by 5 Gy irradiation. This is the first study to report that FAS-AS1 lncRNA is up-regulated by radiation exposure in an ATM-dependent fashion in human T lymphocytes. 25738893
EL0492 FENDRR Xuanwei lung cancer High throughput microarray assay, qRT-PCR Xuanwei lung cancer (XWLC) tissues N/A expression N/A 26642714
EL0492 FENDRR gastric cancer qPCR, Western blot etc. gastric cancer tissue, cell lines (MGC803, BGC823, MKN28, MKN45, SGC7901) down-regulated interaction FENDRR was downregulated in gastric cancer cell lines and cancerous tissues, as compared with normal gastric epithelial cells and adjacent noncancerous tissue samples. Low FENDRR expression was correlated with deeper tumor invasion, higher tumor stage, and lymphatic metastasis. Histone deacetylation was involved in the downregulation of FENDRR in gastric cancer cells. FENDER overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression. 25167886 Lnc2Cancer
EL0493 Fendrr heart failure N/A N/A N/A expression The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. 23369715 LncRNADisease
EL0494 FER1L4 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated N/A FER1L4 expression levels in gastric cancer tissues are significantly decreased. The low FER1L4 level were associated with tumor size, histologic grade, general classification, depth of invasion, lymphatic metastasis , distant metastasis, TNM stage, vessel or nerve invasion.FER1L4 might play a crucial role in human gastric cancer and may be a new potential biomarker for clinical prognosis evaluation. 24961353 Lnc2Cancer
EL0494 FER1L4 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (AGS, MGC-803, SGC-7901) down-regulated interaction We observed that FER1L4 was downregulated in gastric cancer and that its level corresponded with that of PTEN mRNA. Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. Further experiments demonstrated that FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. More importantly, FER1L4 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. 26306906 Lnc2Cancer
EL0495 FEZF1-AS1 colorectal cancer N/A primary colorectal carcinoma (CRC) up-regulated N/A the downregulation of FEZF1-AS1 expression significantly; FEZF1 knockdown also significantly suppressed CRC cell proliferation 26848625
EL0496 FFAR2 enterovirus 71 infection N/A N/A N/A expression A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation 23220233 LncRNADisease
EL0497 FGF10-AS1 Ventricular septal defects N/A N/A N/A expression Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. 24147006 LncRNADisease
EL0498 FGF14-AS2 breast cancer Reduced expression breast cancer tissue down-regulated expression FGF14-AS2 involved in the progress of breast cancer and might act as a tumor suppressor gene. 26820525
EL0499 FGFR3-AS1 osteosarcoma real-time quantitative PCR osteosarcoma up-regulated N/A FGFR3-AS1 inhibits xenograft tumor growth of osteosarcoma cells 27022737
EL0500 FH non-small cell lung cancer NSCLC lines 95D and 95C by using high throughput LncRNA chip 95C, 95D cells and NSCLC tumor tissues up-regulated N/A TATDN1 expression is associated with 95D cells' higher potential of invasion and metastasis 26943769
EL0502 FKBP10 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0504 FMR1-AS1 neurological disorders genome-wide chromatin immunoprecipitation experiments N/A up-regulated N/A alters the chromatin state and the expression of several hundred genes in trans 27001315
EL0504 FMR1-AS1 fragile X syndrome N/A N/A N/A expression ASFMR1 is silenced in FXS patients and up regulated in pre-mutation carriers suggesting that a common process is responsible for regulating the expression these transcripts. 17921506 LncRNADisease
EL0504 FMR1-AS1 fragile X syndrome N/A N/A N/A expression A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. 18213394 LncRNADisease
EL0504 FMR1-AS1 fragile X syndrome N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0504 FMR1-AS1 Fragile X-associated tremor and ataxia syndrome N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL0505 FMR5 fragile X syndrome N/A N/A N/A expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. 24005575 LncRNADisease
EL0505 FMR5 Fragile X-associated tremor and ataxia syndrome N/A N/A N/A expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. 24005575 LncRNADisease
EL0506 FMR6 fragile X syndrome N/A N/A N/A expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. 24005575 LncRNADisease
EL0506 FMR6 Fragile X-associated tremor and ataxia syndrome N/A N/A N/A expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. 24005575 LncRNADisease
EL0507 FOSB hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A To validate the microarray analysis results, five lncRNAs were randomly selected from the differential lncRNAs and their expressions were analyzed using qPCR in 29 pairs of HCC and matched NT tissues. Our data indicated that the expressions of TCONS_00018278, AK093543, D16366 and ENST00000501583 were significantly downregulated in HCC, whereas the expression of NR_002819 showed no significant difference. 24876753 Lnc2Cancer
EL0508 FOXC2-AS1 osteosarcoma microarray, qPCR, Western blot, knockdown etc. cell lines (MG63, SaoS2, U-2OS) up-regulated interaction lncRNA ODRUL was higher in different doxorubicin-resistant OS cell lines and lower in different doxorubicin-sensitive OS cell lines. Moreover, we showed that lncRNA ODRUL was increased in specimens of OS patients with a poor chemoresponse and lung metastasis. We further demonstrated that lncRNA ODRUL inhibition could inhibit OS cell proliferation, migration, and partly reversed doxorubicin resistance in vitro. In addition, we found that the expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene was decreased after the lncRNA ODRUL knockdown. Thus, we concluded that lncRNA ODRUL may act as a pro-doxorubicin-resistant molecule through inducing the expression of the classical multidrug resistance-related ABCB1 gene in osteosarcoma cells. 26408180 Lnc2Cancer
EL0508 FOXC2-AS1 osteosarcoma microarray, qRT-PCR three sets of doxorubicin-resistant MG63/DXR and their paired parental MG63 cells (fold-change >2.0, P<0.05 and FDR <0.05). up-regulated expression The patients of lower expression of it may survive longer than those of higher expression, which suggest that it may serve as a biomarker to predict the chemoresponse and prognosis of steosarcoma patients. 26463625
EL0509 FOXCUT esophageal squamous cell carcinoma qPCR, knockdown etc. esophageal suqmous cell cancer tissue, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) up-regulated expression Notably elevated FOXCUT and FOXC1 expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues, showing strong correlations with poor differentiation, advanced lymph node classification and metastasis. The expression of FOXCUT was positively correlated with expression of FOXC1 in ESCC specimens. And the expression of FOXC1 was also decreased as the FOXCUT expression was silenced by siRNA. Assays in vitro demonstrated that knockdown of either FOXCUT or FOXC1 remarkably inhibited cell proliferation, colony formation, migration, invasion in ESCC cells. 25031703 Lnc2Cancer
EL0509 FOXCUT basal-like breast cancer qPCR, knockdown etc. cell lines (MDA-MB-231, MDA-MB-468) up-regulated interaction The results showed that the expression of FOXCUT and FOXC1 were positively correlated. When the expression of FOXCUT was downregulated by small interfering RNA, the expression of FOXC1 was similarly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, knockdown of FOXCUT markedly inhibited cell proliferation and migration in vitro. In conclusion, FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs. 25516208 Lnc2Cancer
EL0509 FOXCUT oral squamous cell carcinoma qPCR, Western blot, knockdown etc. OSCC tissue, cell lines (Tca8113, OSC-4, SCC1 etc.) up-regulated N/A In this study, we report a new lncRNA FOXC1 upstream transcript (FOXCUT) that was remarkably overexpressed in 23 OSCC patients, as was the adjacent FOXC1 gene. The expressions of FOXC1 and FOXCUT were positively correlated. In conclusion, FOXC1 may be co-amplified with FOXCUT in OSCC, and both of them may be functionally involved in the tumor progression of OSCC. 24889262 Lnc2Cancer
EL0510 FR0257520 prostate cancer RNA-seq, qPCR etc. prostate cancer tissue down-regulated N/A Consistent with the RNA-seq results, PCA3, FR0348383 and MALAT1 overexpression was found in 80% (32/40), 72.5% (29/40), and 82.5% (33/40) of the prostate cancers respectively, whereas decreased FR0257520 expression was found in 82.5% (33/40) of the prostate cancers. 22349460 Lnc2Cancer
EL0511 FR0348383 prostate cancer qRT-PCR Post-digital rectal examination (DRE) first-catch urine specimens prior to prostate biopsies up-regulated expression FR0348383 transcript in post-DRE urine may be a novel biomarker for detection of PCa with great diagnostic value, especially in the grey zone cohort. 25597901
EL0511 FR0348383 prostate cancer RNA-seq, qPCR etc. prostate cancer tissue up-regulated N/A Consistent with the RNA-seq results, PCA3, FR0348383 and MALAT1 overexpression was found in 80% (32/40), 72.5% (29/40), and 82.5% (33/40) of the prostate cancers respectively, whereas decreased FR0257520 expression was found in 82.5% (33/40) of the prostate cancers. 22349460 Lnc2Cancer
EL0512 FRLnc1 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue, cell lines (MGC803, AGS, BGC823, and SGC7901) up-regulated interaction The RNA level of FRLnc1 is upregulated in 49 % (20/41) of cancer samples compared with neighboring non-cancerous stomach tissues. We also identified TGFb1 and Twist as the downstream effectors of FRLnc1 in the regulation of cell migration. Our findings suggest that FRLnc1 is involved in gastric cancer cell migration and for the first time set up the link between FOXM1 and LncRNA in cancer. 25907137 Lnc2Cancer
EL0514 FTX hepatocelluar carcinoma HCC tissues and cells; clinical analysis HCC tissues and cells up-regulated N/A pathway lncRNA Ftx/miR-545/RIG-I promotes HCC development by activating PI3K/Akt signaling 26992218
EL0514 FTX hepatocelluar carcinoma N/A HBV-related HCC tissue up-regulated expression The overexpression of miR-545/374a cluster located in the Ftx lncRNA is partially responsible for a poor prognosis, and monitoring sera levels of miR-545/374a may be a useful diagnostic marker for HCC. 25299640
EL0514 FTX colorectal cancer qPCR, knockdown etc CRC and adjacent normal colorectal tissues, cell lines (HT-29, SW1116, SW480, COLO205) up-regulated expression Long non-coding RNA FTX was significantly upregulated in colorectal cancer tissues, and low long non-coding RNA FTX expression was significantly correlated with differentiation grade, lymph vascular invasion, and clinical stage. Patients with high long non-coding RNA FTX showed poorer overall survival than those with low long non-coding RNA FTX. Multivariate analyses indicated that status of long non-coding RNA FTX was an independent prognostic factor for patients. Functional analyses showed that upregulation of long non-coding RNA FTX significantly promoted growth, migration, invasion, and increased colony formation in colorectal cancer cells. 26629053 Lnc2Cancer
EL0518 GACAT1 gastric cancer qPCR etc. gastric cancer tissue down-regulated N/A The results showed that AC096655.1-002 was significantly downregulated in gastric cancer tissues compared with paired adjacent non-tumorous tissues (P < 0.001). Its expression level was significantly correlated with lymph node metastasis (P < 0.001), distant metastasis (P < 0.001), tumor-node-metastasis stages (P < 0.001), and differentiation (P = 0.030). In a primary screen of global lncRNA expression profile in gastric cancer, we found that AC096655.1-002 (Ensembl: ENST00000419650) may contribute gastric cancer occurrence. 23645148 Lnc2Cancer
EL0519 GACAT2 non-small cell lung cancer qPCR etc. NSCLC tissue, cell lines (A549, H157, HEK-293T) down-regulated expression lncRNA HMlincRNA717 expression level was significantly decreased in NSCLC tissues in comparison to adjacent non-tumor tissues. It was also proved that HMlincRNA717 expression was to be associated with NSCLC histological grade, and lymph node metastasis. In addition, survival analysis proved that down-regulated HMlincRNA717 expression was associated with poor overall survival of NSCLC patients. HMlincRNA717 expression was an independent prognostic factor for patients with NSCLC, which might be a potential prognostic biomarker and therapeutic target for NSCLC. 25674259 Lnc2Cancer
EL0519 GACAT2 gastric cancer qPCR, PIR etc. gastric cancer tissue, cell lines (AGS, BGC-823, HGC-27, MGC-803, SGC-7901 etc.) down-regulated N/A The expression levels of HMlincRNA717 in five gastric cancer cell lines, AGS, BGC-823, HGC-27, MGC-803, and SGC-7901, were significantly downregulated than those in normal gastric mucosal epithelial cell line GES-1. More importantly, our results indicated that HMlincRNA717 expression levels were correlated with cancer distal metastasis (P = 0.034), venous invasion (P = 0.029), and nervous invasion (P = 0.024). lncRNA-HMlincRNA717 may play crucial roles during cancer occurrence and progression and may be a new potential biomarker of early gastric cancer. 24961350 Lnc2Cancer
EL0520 GACAT3 gastric cancer qPCR etc. gastric cancer tissue, cell lines (AGS, BGC-823, MGC-803, SGC-7901 etc.) up-regulated N/A AC130710 in gastric cancer was significantly higher. Its expression level was significantly associated with tumor size, tumor-node-metastasis (TNM) stages, and distal metastasis. miR-129-5p may play an important role in the downregulation of AC130710 in gastric cancer cells. These results indicated that lncRNA-AC130710 may be a potential tumor marker for gastric cancer prognosis. 24969565 Lnc2Cancer
EL0521 GADD45G pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated N/A In summary, MEG3 and GADD45γexpression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. 21850407 Lnc2Cancer
EL0523 GAPLINC gastric cancer microarray, ISH etc. gastric cancer tissue up-regulated N/A GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. GAPLINC suppression and with gene expression profiling in gastric cancer cells revealed alterations in cell migration pathways, with CD44 expression the most highly correlated. Manipulating GAPLINC 25277524 LncRNADisease Lnc2Cancer
EL0524 GAS1RR twist-positive breast cancer microarray, qRT-PCR Twist-positive mammosphere cells N/A interaction lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor. 26418365
EL0525 GAS2L3 colorectal cancer microarray, qPCR, knockdown etc. cell lines (HCT116 ,SW1116) down-regulated N/A Functional experiments demonstrated three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines. 24809982 Lnc2Cancer
EL0526 GAS5 breast cancer GAS5 HREM sequence alone promotes the apoptosis of breast cancer cells hormone-sensitive and -insensitive breast cancer cell lines up-regulated N/A induce apoptosis in breast cancer cells 26862727
EL0526 GAS5 lymphoma knockdown etc. cell lines (Jeko-124 and Z-138) down-regulated N/A Downregulation of GAS5 substantially reduced the effects of each rapalogue on cell viability, DNA synthesis, and colony-forming ability.Stimulation of expression of candidate tumor suppressor GAS5 is responsible for much of the cytotoxic and cytostatic effects of rapalogues in MCL, suggesting that improved targeting of this pathway may allow improvements in the therapy of this intractable lymphoma. 24703244 Lnc2Cancer
EL0526 GAS5 type 2 diabetes mellitus lncRNA arrays, quantitative PCR Serum samples obtained from 96 participating veterans at JAH VA N/A expression Decreased GAS5 levels in serum were associated with diabetes in a cohort of US military veterans. 26674525
EL0526 GAS5 hepatocelluar carcinoma microarray, qPCR etc. HBV-related HCC tissue up-regulated expression Four upregulated lncRNAs were randomly selected and analyzed for their expression levels in tissue samples from 14 HBV-related HCC patients. The corresponding non-tumor tissues were analyzed via qPCR, in which the obtained results are consistent with the microarray data. 26109807 Lnc2Cancer
EL0526 GAS5 ovarian cancer microarray, qPCR, knockdown etc. EOC tissue, cell lines (HO8910, A2780) down-regulated interaction The data show that no significant differences of GAS5 expression were observed between normal ovarian epithelium and benign epithelial lesions; however, GAS5 expression was lower in EOC tissues compared with normal ovarian epithelial tissues, which was closely related to lymph node metastasis and tumor node metastasis stage. Finally, through mitochondrial potential and western blot analyses, GAS5 could disrupt mitochondrial membrane potential and promote BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 expression. 26503132 Lnc2Cancer
EL0526 GAS5 breast cancer microarray, qRT-PCR SKBR-3/Tr cells down-regulated N/A GAS5 promoted SKBR-3 cell proliferation 27034004
EL0526 GAS5 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0526 GAS5 stomach cancer N/A stomach cancer tissues down-regulated expression In this study, we found that lncRNA GAS5 had lower expression in stomach cancer tissues than the normal counterparts. These results delineate a novel mechanism of lncRNA GAS5 in suppressing stomach carcinogenesis, and the lncRNA GAS5/YBX1/p21 pathway we discovered may provide useful targets for developing lncRNA-based therapies for stomach cancer. 25959498
EL0526 GAS5 lymphoma N/A N/A N/A mutation The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. 18406879 LncRNADisease
EL0526 GAS5 lymphoma N/A N/A N/A mutation Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer. 18836484 LncRNADisease Lnc2Cancer
EL0526 GAS5 melanoma N/A N/A N/A mutation Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer. 18836484 LncRNADisease Lnc2Cancer
EL0526 GAS5 autoimmune disease N/A N/A N/A expression Increased lncRNA Gas5 activity in immune cells could suppress GR-induced transcriptional activity and contribute to the development of autoimmune disease. 20124551 LncRNADisease
EL0526 GAS5 tumor N/A N/A N/A regulation Binding to GR as a decoy and blocking transcriptional induction by GR, induces growth arrest and apoptosis. 22996375 LncRNADisease
EL0526 GAS5 kidney cancer N/A N/A N/A expression Tumour suppressor 24373479 LncRNADisease
EL0526 GAS5 prostate cancer N/A N/A N/A expression Tumour suppressor; putative oncogene host 24373479 LncRNADisease
EL0526 GAS5 tumor N/A N/A N/A regulation ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators. 24667321 LncRNADisease
EL0526 GAS5 tumor N/A N/A N/A regulation Our own work suggests that while RoR (Zhang et al., 2013a) may function as an oncogene through suppression of p53 in response to DNA damage, loc285194 (Liu et al., 2013) and GAS5 (Zhang et al., 2013b) may play a tumor suppressive role through the “competitive endogenous RNA” (CeRNA) mechanism (Salmena et al., 2011). 24721780 LncRNADisease
EL0526 GAS5 cancer N/A N/A N/A regulation Pickard et al. showed that GAS5 promotes apoptosis of prostate cells after irradiation with UV, and low GAS5 expression therefore reduces the effectiveness of chemotherapeutic agents. 24757675 LncRNADisease
EL0526 GAS5 liver fibrosis overexpression mouse, rat, and human fibrotic liver samples, activated hepatic stellate cell (HSC) down-regulated interaction GAS5 increased the level of p27 protein by functioning as a competing endogenous RNA for miR-222, thereby inhibiting the activation and proliferation of HSCs. Overexpression of GAS5 suppressed the activation of primary HSCs in vitro and alleviated the accumulation of collagen in fibrotic liver tissues in vivo. GAS5 was identified as a target of microRNA-222 (miR-222) and showed that miR-222 could inhibit the expression of GAS5. GAS5 could also repress miR-222 expression. 26446789
EL0526 GAS5 prostate cancer qPCR etc. cell lines (HEK 293T, LNCaP, W7.2c etc.) down-regulated mutation Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer. 18836484 LncRNADisease Lnc2Cancer
EL0526 GAS5 breast cancer qPCR etc. cell lines (HEK 293T, LNCaP, W7.2c etc.) down-regulated expression GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. 18836484 LncRNADisease Lnc2Cancer
EL0526 GAS5 cervical cancer qPCR etc. cell line (CaSki) up-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL0526 GAS5 renal cell carcinoma qPCR etc. renal cell carcinoma tissue, cell lines (A498, HK-2 etc.) down-regulated N/A The expression of GAS5 was lower in the RCC cell line A498 than that in normal renal cell line HK-2. Furthermore, using functional expression cloning, we found that overexpression of GAS5 in A498 cells inhibited cell proliferation, induced cell apoptosis and arrested cell cycling. Our study provided the first evidence that a decrease in GAS5 expression is associated with RCC genesis and progression and overexpression of GAS5 can act as a tumor suppressor for RCC, providing a potential attractive therapeutic approach for this malignancy. 23621190 Lnc2Cancer
EL0526 GAS5 multiple myeloma qPCR etc. blood (plasma) down-regulated expression HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. 24583225 LncRNADisease Lnc2Cancer
EL0526 GAS5 hepatocelluar carcinoma qPCR etc. HCC tissue down-regulated expression The expression level of GAS5 was reduced in HCC in comparison to normal matched tissues (P < 0.05). It is also proved that GAS5 expression was to be associated with HCC tumor size, lymphnode metastasis and clinical stage (P < 0.05). In addition, the Kaplan-Meier survival curves revealed that low GAS5 expression was associated with poor prognosis in HCC patients. GAS5 expression was an independent prognostic marker of overall HCC patient survival in a multivariate analysis. 25120813 Lnc2Cancer
EL0526 GAS5 breast cancer qPCR etc. breast cancer tissues and postoperative blood samples down-regulated interaction Analysis in the 39 paired preoperative and postoperative plasma samples showed that lower GAS5 levels appeared in the patients with a high Ki67 proliferation index before surgery and the patients with a positive lymph node metastasis state after surgery. Plasma lncRNA GAS5 may have the potential to assess the surgical effects and prognosis for BC patients 26662314 Lnc2Cancer
EL0526 GAS5 colorectal cancer qPCR, FCA etc. CRC tissue down-regulated expression The lower expression of GAS5 was significantly correlated with large tumor size, low histological grade and advanced TNM stage. Multivariate analyses revealed that GAS5 expression served as an independent predictor for overall survival. Further experiments revealed that overexpressed GAS5 significantly repressed the proliferation both in vitro and in vivo. 25326054 Lnc2Cancer
EL0526 GAS5 prostate cancer qPCR, knockdown etc. cell lines (22Rv1, PC-3 etc.) up-regulated N/A GAS5 promotes the apoptosis of prostate 34 cells, and exonic sequence, i.e. GAS5 lncRNA, is sufficient to mediate this activity. Abnormally low levels of 35 GAS5 expressionmay therefore reduce the effectiveness of chemotherapeutic agents. 23676682 Lnc2Cancer
EL0526 GAS5 breast cancer qPCR, knockdown etc. cell lines (MCF7, T-47D) down-regulated regulation GAS5?lncRNA?promoted the apoptosis of triple-negative and oestrogen receptor-positive cells but only dual PI3K/mTOR inhibition was able to enhance GAS5 levels in all cell types. Reduced GAS5 expression attenuates apoptosis induction by classical chemotherapeutic agents in breast cancer cells, providing an explanation for the relationship between GAS5 expression and breast cancer patient prognosis.? 24789445 LncRNADisease Lnc2Cancer
EL0526 GAS5 malignant pleural mesothelioma qPCR, knockdown etc. MPM tissue, cell lines (SPC111, SPC212, ZL34, ZL55) down-regulated N/A GAS5 expression was lower in MPM cell lines compared to normal mesothelial cells. GAS5 was upregulated upon growth arrest induced by inhibition of Hedgehog and PI3K/mTOR signalling in in vitro MPM models. The increase in GAS5 lncRNA was accompanied by increased promoter activity. Silencing of GAS5 increased the expression of glucocorticoid responsive genes glucocorticoid inducible leucine-zipper and serum/glucocorticoid-regulated kinase-1 and shortened the length of the cell cycle. Drug induced growth arrest was associated with GAS5 accumulation in the nuclei. GAS5 was abundant in tumoral quiescent cells and it was correlated to podoplanin expression. 24885398 Lnc2Cancer
EL0526 GAS5 cervical cancer qPCR, knockdown etc. cervical cancer tissue down-regulated expression We found that GAS5 expression was markedly downregulated in cervical cancer tissues than in corresponding adjacent normal tissues. Decreased GAS5 expression was significantly correlated with FIGO stage, vascular invasion and lymph node metastasis. Moreover, cervical cancer patients with GAS5 lower expression have shown significantly poorer overall survival than those with higher GAS5 expression. And GAS5 expression was an independent prognostic marker of overall survival in a multivariate analysis. 25400758 Lnc2Cancer
EL0526 GAS5 lung adenocarcinoma qPCR, Western blot etc. lung cancer tissue, cell lines (A549, H1299, H1975, HCC827) down-regulated interaction Our results showed that GAS5 was significantly downregulated in lung adenocarcinoma tissues compared with the paired adjacent non-tumorous tissue samples. Furthermore, lower GAS5 expression levels were associated with larger tumor sizes, poor tumor differentiation, and advanced pathological stages. GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins. 25925741 Lnc2Cancer
EL0526 GAS5 non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, H1650, H1299, H1975, SK-MES etc.) down-regulated N/A The results revealed that GAS5 expression was down-regulated in cancerous tissues compared to adjacent noncancerous tissues (P < 0.05) and was highly related to tumor size and TNM stage (P < 0.05). This correlation between GAS5 and clinicopathological parameters indicates that GAS5 might function as a tumor suppressor. Furthermore, GAS5 overexpression increased tumor cell growth arrest and induced apoptosis in vitro and in vivo. 24357161 Lnc2Cancer
EL0526 GAS5 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, MKN45, MKN28) down-regulated N/A GAS5 expression was markedly downregulated in gastric cancer tissues. Moreover, ectopic expression of GAS5 was demonstrated to decrease gastric cancer cell proliferation and induce apoptosis, while downregulation of endogenous GAS5 could promote cell proliferation. GAS5 could influence gastric cancer cells proliferation, partly via regulating E2F1 and P21 expression. 24884417 Lnc2Cancer
EL0526 GAS5 endometrial cancer qPCR, Western blot, knockdown, Luciferase reporter assay, Flow cytometry assay etc. endometrial cancer tissue, cell lines (HHUA, JEC) down-regulated interaction We identified that GAS5 was down-regulated in endometrial cancer cells and stimulated the apoptosis of endometrial cancer cells. In summary, we demonstrate that GAS5 acts as an tumor suppressor lncRNA in endometrial cancer. Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis, and, thus, could be an important mediator in the pathogenesis of endometrial cancer. 26511107 Lnc2Cancer
EL0526 GAS5 bladder cancer qPCR, Western blot, knockdown, RIP etc. bladder cancer tissue, cell lines (T24, DSH1, RT112, RT4, KU7, 253J etc.) down-regulated N/A In the present study, we found that the GAS5 expression is commonly downregulated in bladder cancer cell lines and human specimens. Knockdown of GAS5 promotes bladder cancer cell proliferation, whereas forced expression of GAS5 suppresses cell proliferation. We further demonstrated that knockdown of GAS5 increases CDK6 mRNA and protein levels in bladder cancer cells. Expectedly, GAS5 inhibition induces a significant decrease in G0/G1 phase and an obvious increase in S phase. 24069260 Lnc2Cancer
EL0526 GAS5 hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay, knockdown etc. cell lines (Sk-Hep-1, BEL-7404, Huh7) up-regulated expression rs145204276 may contribute to hepatocarcinogenesis by affecting methylation status of the GAS5 promoter and subsequently its transcriptional activity thus serving as a potential therapy target for HCC. 26163879 Lnc2Cancer
EL0526 GAS5 hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. HCC tissue, cell lines (Bel-7402, SMMC-7721, HCCLM3 etc.) down-regulated interaction The present report demonstrates that there are lower levels of GAS5, PDCD4, and PTEN and higher levels of microRNA-21 (miR-21) in HCC tissues than in adjacent normal tissues. Then, overexpression of GAS5 suppresses the migration and invasion of HCC cells and high expression of miR-21 largely eliminates GAS5-mediated suppression of HCC cell migration and invasion. 26404135 Lnc2Cancer
EL0526 GAS5 pancreatic cancer qPCR, Western bolt etc. pancreatic cancer tissue, cell lines (BxPC-3, PANC-1, AsPC-1, Hs766T etc.) down-regulated N/A We verify that the expression level of gas5 is significantly decreased in pancreatic cancer tissues compared with normal control. Overexpression of gas5 in pancreatic cancer cells inhibits cell proliferation, whereas gas5 inhibition induces a significant decrease in G0/G1 phase and an increase in S phase. We further demonstrate that gas5 negatively regulates CDK6 expression in vitro and in vivo. More importantly, knockdown of CDK6 partially abrogates gas5-siRNA-induced cell proliferation. 24026436 Lnc2Cancer
EL0526 GAS5 hepatocelluar carcinoma Quantitative polymerase chain reaction and in situ hybridization Hepatocellular carcinoma (HCC) tissues down-regulated interaction Overexpression of GAS5 significantly suppressed the proliferation and invasion of hepatoma cells in vitro, promoted the apoptosis of hepatoma cells. 26707238
EL0526 GAS5 melanoma quantitative real-time polymerase chain reaction SK-Mel‑110 melanoma cell down-regulated N/A Overexpressing lncRNA GAS5 inhibited the migration and invasion 26846479
EL0526 GAS5 breast cancer RT-PCR (reverse transcription-polymerase chain reaction) array breast tumor specimens, xenograft mouse model N/A interaction GAS5 functions as a tumor suppressor. miR-21 is capable of suppressing the lncRNA growth arrest-specific 5 (GAS5). GAS5 can also repress miR-21 expression. 23933812
EL0526 GAS5 prostate cancer siRNA prostate cancer cells up-regulated expression mTOR inhibition enhances GAS5 transcript levels in certain prostate cancer cell lines. This selectivity is likely to be related to endogenous GAS5 expression levels. 25650269
EL0526 GAS5 varicose great saphenous veins siRNA varicose great saphenous veins (GSVs) varicosities down-regulated expression The low expression of lncRNA-GAS5 may facilitate HSVSMCs proliferation and migration through Annexin A2 and thereby the pathogenesis of GSV varicosities 25806802
EL0527 Gas5 systemic lupus erythaematosus N/A N/A N/A N/A The Gas5 transcript has been linked with increased susceptibility to systemic lupus erythaematosus in mouse models, presumably as a result of its effect on the immunosuppressant role of glucocorticoids 22817756 LncRNADisease
EL0528 GAS6-AS1 non-small cell lung cancer qPCR etc. NSCLC tissue down-regulated N/A In this study, we reported a new lncRNA GAS6-AS1, whose expression was downregulated in tumor tissues in 50 patients with NSCLC compared with those in the adjacent normal tissues. Furthermore, decreased GAS6-AS1 expression was negatively correlated with lymph node metastasis and advanced tumor node metastasis stage. Univariate and multivariate analyses showed that GAS6-AS1 expression served as an independent predictor for overall survival. Altered lncRNA GAS6-AS1 expression might be involved in the development and progression of NSCLC by influencing its host gene and promised to be a potential diagnostic target in patients with NSCLC. 23979857 Lnc2Cancer
EL0529 GAS8-AS1 papillary thyroid carcinoma NGS Chinese PTC using 402 tumor-normal pairs N/A N/A higher capability to inhibit cancer cell growth 26941397
EL0530 GATA3-AS1 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL0531 GDNF-AS1 Alzheimer's disease N/A N/A N/A expression The findings of novel GDNF and GDNFOS isoforms and differences in tissue expression patterns dysregulated in AD brains may further reveal the role of endogenous GDNF in human brain diseases. 22081608 LncRNADisease
EL0533 GHET1 gastric cancer hypoxia-induced GC and normoxia conditions using microarrays hypoxia-induced GC cells up-regulated N/A lncRNA-AK123072/EGFR pathway in gastric cancer pathogenesis 26884908
EL0533 GHET1 gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. 26096073 Lnc2Cancer
EL0533 GHET1 bladder cancer qPCR, Western blot, in vitro knockdown etc. bladder cancer tissue up-regulated expression In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. 25400817 Lnc2Cancer
EL0533 GHET1 gastric cancer qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. gastric cancer tissue, cell lines (MKN45, AGS etc.) up-regulated regulation Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. 24397586 LncRNADisease Lnc2Cancer
EL0534 GHSR non-small cell lung cancer qPCR, Northern bolt etc. lung cancer tissue, cell lines (A549, NCI-H1299, Beas-2B etc.) up-regulated N/A Quantitative real-time RT-PCR revealed higher expression of GHSROS in lung cancer tissue compared to adjacent, non-tumour lung tissue. GHSROS function may be dependent on the oncogenic context. The identification of GHSROS, which is expressed in lung cancer and stimulates cell migration in lung cancer cell lines, contributes to the growing number of non-coding RNAs that play a role in the regulation of tumourigenesis and metastatic cancer progression. 23722988 Lnc2Cancer
EL0536 Gm10371 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 27 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0542 Gm32592 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 11 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0543 Gm6644 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 12 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0544 GNAS-AS1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL0544 GNAS-AS1 pseudohypoparathyroidism type Ib N/A N/A N/A mutation Deletion of the nespas causes pseudohypoparathyroidism Type Ib. 20444925 LncRNADisease
EL0551 AF181450.1 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0552 GSTT1-AS1 Mycobacterium tuberculosis infection knock-down CD244(+)CD8(+) T-cell line up-regulated expression CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1 (1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation. CD244 signaling drives lncRNA-CD244 expression via sustaining a permissive chromatin state in the lncRNA-CD244 locus. 26150504
EL0553 GUCY1B2 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL0555 H19 overgrowth transgenic embryos of mice lacking H19 down-regulated mutation Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. 19762426
EL0556 H19 colorectal cancer a case-control study N/A N/A N/A N/A 27027436
EL0556 H19 gastric cancer AGS cells, knock out of H19 gastric cancer AGS cells down-regulated N/A H19 or miR-675 enhanced RUNX1 expression 26931432
EL0556 H19 osteoarthritis cDNA array and quantitative RT-PCR OA and normal knee cartilage up-regulated interaction LncRNA H19 acts as a metabolic correlate in cartilage and cultured chondrocytes, while the miR-675 may indirectly influence COL2A1 levels. H19 may not only be an attractive marker for cell anabolism but also a potential target to stimulate cartilage recovery 22527881
EL0556 H19 gallbladder cancer gallbladder cancer gallbladder cancer tissues and adjacent normal tissues up-regulated N/A The overexpression of H19 in GBC cells enhanced tumor invasion and promoted EMT 27073719
EL0556 H19 bladder cancer ISH etc. bladder cancer tissue etc. differential expression expression The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma. 11193051 LncRNADisease Lnc2Cancer
EL0556 H19 gestational choriocarcinoma ISH etc. placenta tissue up-regulated expression Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma. 8188082 LncRNADisease Lnc2Cancer
EL0556 H19 trophoblastic tumor ISH etc. placenta tissue up-regulated expression Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma. 8188082 LncRNADisease Lnc2Cancer
EL0556 H19 laryngeal squamous cell carcinoma knockdown LSCC patients up-regulated N/A The inhibition of LSCC progression induced by H19 knockdown required the activity 26872375
EL0556 H19 nasopharyngeal carcinoma knockdown NPC tissues up-regulated N/A H19 regulated EZH2 expression suppressing the activity of miR-630 27040767
EL0556 H19 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We found that imbalances in levels of IGF2 and H19 transcripts were correlated with advanced tumor stage and poor outcome in HCC patients. 15736456 LncRNADisease Lnc2Cancer
EL0556 H19 gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (GES-1, AGS, MGC-803, SGC-7901) up-regulated N/A As shown in Figure 2D, comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). 24063685 Lnc2Cancer
EL0556 H19 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL0556 H19 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A H19 expression level was 4.97 to 13.58-fold higher in GCa samples than the mean level in paired non-cancerous tissues. Moreover, the expression levels of H19 were increased significantly in the tumors of patients with advanced clinical stage (p < 0.001) and larger tumor size ( p < 0.001). 24414129 Lnc2Cancer
EL0556 H19 gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) up-regulated expression H19 and HOTAIR displayed significantly higher levels and the up-regulation of HOTAIR was associated with lymphatic metastasis and poor differentiation. 26237576 Lnc2Cancer
EL0556 H19 hepatocelluar carcinoma microarray, qPCR, knockdown, ISH etc. cell lines (T24P, HepG2, Hep3B etc.) up-regulated N/A The H19 non-coding RNA is essential for human tumor growth. 17786216 LncRNADisease Lnc2Cancer
EL0556 H19 bladder cancer microarray, qPCR, knockdown, ISH etc. cell lines (T24P etc.) up-regulated N/A The H19 non-coding RNA is essential for human tumor growth. 17786216 LncRNADisease Lnc2Cancer
EL0556 H19 ovarian cancer microarray, qPCR, Western blot etc. cell lines (OVCAR-3, OV-90 and SK-OV-3) down-regulated interaction We find that overexpression of H1.3 decreases the growth rate and colony formation of OVCAR-3 cells. We identify histone H1.3 as a specific repressor for the noncoding oncogene H19. Overexpression of H1.3 suppresses H19 expression, and knockdown of H1.3 increases its expression in multiple ovarian epithelial cancer cell lines. Furthermore, we demonstrate that histone H1.3 overexpression leads to increased occupancy of H1.3 at the H19 regulator region encompassing the imprinting control region (ICR), concomitant with increased DNA methylation and reduced occupancy of the insulator protein CTCF at the ICR. Finally, we demonstrate that H1.3 overexpression and H19 knockdown synergistically decrease the growth rate of ovarian cancer cells 25205099 Lnc2Cancer
EL0556 H19 glioma microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. glioma tissue, cell lines (U87, U251 etc.) up-regulated regulation Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675. 24466011 LncRNADisease Lnc2Cancer
EL0556 H19 colorectal cancer Multivariate analyses 83 CRC patients up-regulated N/A overexpression of H19 promoted the proliferation of CRC cells; growth regulator 26989025
EL0556 H19 choricarcinoma N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 type 2 diabetes mellitus N/A muscle of human subjects with type-2 diabetes and insulin resistant rodents. down-regulated expression H19 is significantly decreased in muscle of human subjects with type-2 diabetes and insulin resistant rodents. This decrease leads to increased bioavailability of let-7, causing diminished expression of let-7 targets, which is recapitulated in vitro where H19 depletion results in impaired insulin signaling and decreased glucose uptake. 25399420
EL0556 H19 glioblastoma multiforme N/A GBM cell lines up-regulated N/A H19 in contributing to GBM malignancy 26983719
EL0556 H19 cardiac hypertrophy N/A normal and diseased hearts up-regulated N/A overexpression of H19 reduced cell size both at baseline and in response to PE; knockdown of H19 induced cardiomyocyte hypertroph 27084844
EL0556 H19 heart failure N/A normal and diseased hearts up-regulated N/A overexpression of H19 reduced cell size both at baseline and in response to PE; knockdown of H19 induced cardiomyocyte hypertroph 27084844
EL0556 H19 myeloproliferative disease polycythaemia vera N/A N/A N/A expression Expression of the imprinted tumour-suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera. 10640993 LncRNADisease
EL0556 H19 Marek's disease N/A N/A N/A mutation The mutant CVI/rpp38 was not only reactive with MAb H19 in IFA but also in immunoprecipitation. 10696440 LncRNADisease
EL0556 H19 congenital hyperinsulinism N/A N/A N/A expression In agreement with the loss of the maternal chromosome, the level of expression of a maternally expressed tumor suppressor gene, H19, was greatly reduced compared to the level of expression of the paternally expressed growth promoter gene, IGF2. 11395395 LncRNADisease
EL0556 H19 Beckwith-Wiedemann syndrome N/A N/A N/A epigenetics Mosaicism for 11p15 UPD and hypermethylation of the H19 gene in blood cells were associated with an increased risk of tumour. 11436121 LncRNADisease
EL0556 H19 melanoma N/A N/A N/A expression The study of 4 sensitive and 2 resistant cell lines allowed the identification of 4 genes (RCC1, IFI16, hox2 and h19) preferentially transcribed in sensitive ((IFN-alpha therapy) cells and 2 (SHB and PKC-zeta) preferentially expressed in resistant cells. 11437411 LncRNADisease
EL0556 H19 Beckwith-Wiedemann syndrome N/A N/A N/A epigenetics Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. 11813134 LncRNADisease
EL0556 H19 gestational trophoblastic diseases N/A N/A N/A expression LOI, deregulation of IGF2 promoters, and the altered expression levels of IGF2 and H19 genes might be associated with the progression of GTD. 12648595 LncRNADisease
EL0556 H19 chronic myeloproliferative disorders N/A N/A N/A expression Reduced expression of H19 in bone marrow cells from chronic myeloproliferative disorders. 12682647 LncRNADisease
EL0556 H19 biparental complete hydatidiform moles N/A N/A N/A epigenetics H19 is abnormally methylated on the maternal alleles in BiCHMs. 12783848 LncRNADisease
EL0556 H19 Beckwith-Wiedemann syndrome N/A N/A N/A mutation Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. 15314640 LncRNADisease
EL0556 H19 colon cancer N/A N/A N/A expression DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. 15521051 LncRNADisease
EL0556 H19 cancer N/A N/A N/A expression The human H19 gene is frequently overexpressed in myometrium and stroma during pathological endometrial proliferative events. 15618002 LncRNADisease
EL0556 H19 hyperhomocysteinemia N/A N/A N/A epigenetics The effect of hyperhomocysteinemia on H19 DMD methylation was tissue-specific. hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice. 15899898 LncRNADisease
EL0556 H19 cancer N/A N/A N/A expression H19 expression was found in the hepatic metastases of 64 of 80 patients. High expression (higher staining grades) of H19 in the metastases was found in 43 of 80 patients. However, H19 expression status in the hepatic metastases did not correlate with either the length of time to development of metastasis or overall survival. 16189152 LncRNADisease
EL0556 H19 Beckwith-Wiedemann syndrome N/A N/A N/A locus The H19 locus acts in vivo as a tumor suppressor. 18719115 LncRNADisease
EL0556 H19 Silver-Russell syndrome N/A N/A N/A mutation Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome 19066168 LncRNADisease
EL0556 H19 pre-eclampsia N/A N/A N/A mutation LOI of H19 can be identified in pre-eclamptic placentas and is associated with maternal blood pressures, which implies the involvement of H19 gene LOI in the pathogenesis of pre-eclampsia and its potential relationship with the severity of the disease. 19570415 LncRNADisease
EL0556 H19 melanoma N/A N/A N/A expression H19 RNA downregulation stimulated melanogenesis in melasma. 19968822 LncRNADisease
EL0556 H19 infertility N/A N/A N/A expression H19 expression was lower in the infertility group as compared to the control group. 20042264 LncRNADisease
EL0556 H19 growth restriction N/A N/A N/A epigenetics A loss of methylation at H19. 20104244 LncRNADisease
EL0556 H19 glioblastoma N/A N/A N/A expression Another study performed in CD133+ and CD133- glioblastoma derived primary cell lines revealed levels of H19 expression that were relatively high and low, respectively. 20380817 LncRNADisease
EL0556 H19 medulloblastoma N/A N/A N/A epigenetics A study of medulloblastomas and medulloblastoma cell lines showed partial loss of imprinting (LOI) and biallelic expression of H19. 20380817 LncRNADisease
EL0556 H19 meningioma N/A N/A N/A epigenetics An examination of meningiomas (World Health Organization grades I-III) demonstrated more robustly that the imprinting status of H19 is perturbed with LOI in a significant number of these tumors. 20380817 LncRNADisease
EL0556 H19 melanoma N/A N/A N/A mutation Although the IGF2 and H19 genotypes/haplotypes were not significantly associated with melanoma, two of the most severe cases (very early onset or multiple melanomas) showed to be heterozygous for both genes. 20483645 LncRNADisease
EL0556 H19 Wiedemann-Beckwith syndrome N/A N/A N/A epigenetics Genetic analyses of the patient's blood showed hypermethylation at the H19 locus on chromosome 11p. 21058226 LncRNADisease
EL0556 H19 Silver-Russell syndrome N/A N/A N/A epigenetics The major finding (~44%) is a hypomethylation of the imprinting control region 1 (ICR1) in 11p15.5 affecting the expression of H19 and IGF2. 4-10% of the patients carry a maternal UPD of chromosome 7 (UPD(7)mat). 21150838 LncRNADisease
EL0556 H19 liver cancer N/A N/A N/A epigenetics H19 ICR showed loss-of-imprinting in two steps and allelic histone marker signature during tumorigenesis showed similarity with ES cells. 21163252 LncRNADisease
EL0556 H19 Mullerian aplasia N/A N/A N/A epigenetics Methylation of H19 and its imprinted control region (H19 ICR1) in Mullerian aplasia. 21458801 LncRNADisease
EL0556 H19 colon cancer N/A N/A N/A N/A Regional therapy with DTA-H19 vector suppresses growth of colon adenocarcinoma metastases in the rat liver. 21874233 LncRNADisease
EL0556 H19 pheochromocytoma N/A N/A N/A mutation Tumor DNA from the index patient revealed loss of heterozygosity (LOH) at 11q23, causing loss of the wild-type paternal SDHD allele and LOH affecting maternal 11p15, including H19. 21937622 LncRNADisease
EL0556 H19 atherosclerosis N/A N/A N/A epigenetics The most pronounced differences of atherosclerotic plaques in DNA methylation levels were registered for a site which is located in CpG-island of imprinted gene H19. 21954592 LncRNADisease
EL0556 H19 breast cancer N/A N/A N/A mutation Different SNPs in LSP1 and H19 and in minor genes probably were associated with BC risk. 21996731 LncRNADisease
EL0556 H19 adrenocortical carcinomas N/A N/A N/A epigenetics This disease has been associated with structural abnormalities at the 11p15 locus, which harbors the IGF2 gene as well as the genes coding for insulin, H19, and p57kip2. 22019903 LncRNADisease
EL0556 H19 neural tube defects N/A N/A N/A epigenetics The methylation levels of H19 DMR1 in the NTD and control groups are 73.3%卤15.9 and 58.3%卤11.2, respectively. Hyper-methylation of the H19 DMR1 may be correlated with the occurrence of NTDs. 22234160 LncRNADisease
EL0556 H19 obesity N/A N/A N/A epigenetics Insulin-like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in Children. 22341586 LncRNADisease
EL0556 H19 Wilms' tumor N/A N/A N/A epigenetics 37% of patients with Wilms' tumor were H19 epimutations. 22470196 LncRNADisease
EL0556 H19 bladder cancer N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 breast cancer N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 colon cancer N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 esophageal squamous cell carcinoma N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 liver cancer N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 lung cancer N/A N/A N/A regulation Control of imprinting. Containing miRNA miR-675. 22996375 LncRNADisease
EL0556 H19 tumor N/A N/A N/A epigenetics In recent years, we have extensively investigated the expression of the H19 gene in a number of human cancers and explored the role of H19 RNA in tumor development. 23429271 LncRNADisease
EL0556 H19 tumor N/A N/A N/A expression H19, a lncRNA with oncogenic properties, is upregulated in a wide range of tumours. 23660942 LncRNADisease
EL0556 H19 glioma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 medulloblastoma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 meningioma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 neuroblastoma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 pituitary adenoma N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 Prader-Willi syndrome N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0556 H19 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL0556 H19 hepatocelluar carcinoma N/A N/A N/A expression Dysregulation and functional roles of lncRNAs in HCC 24183851 LncRNADisease
EL0556 H19 kidney cancer N/A N/A N/A regulation Tumour suppressor; tumour suppressor host 24373479 LncRNADisease
EL0556 H19 bladder cancer N/A N/A N/A expression Prognostic marker low-risk marker Oncogene targeted therapy agent 24373479 LncRNADisease
EL0556 H19 prostate cancer N/A N/A N/A expression Putative susceptibility and diagnostic marker 24373479 LncRNADisease
EL0556 H19 bladder cancer N/A N/A N/A regulation Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon 24499465 LncRNADisease
EL0556 H19 liver cancer N/A N/A N/A regulation Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon 24499465 LncRNADisease
EL0556 H19 lung cancer N/A N/A N/A regulation Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon 24499465 LncRNADisease
EL0556 H19 tumor N/A N/A N/A regulation Oncofetal H19 RNA promotes tumor metastasis. 24703882 LncRNADisease
EL0556 H19 hepatocelluar carcinoma N/A N/A N/A expression Overexpression of H19 was found in hepatocellular carcinoma.? 24757675 LncRNADisease
EL0556 H19 gastric cancer N/A N/A N/A regulation Using real-time RT-PCR, flow cytometry, RNA immunoprecipitation and other methods, Yang et al confirmed that H19 expression in gastric cancer accelerated cell proliferation. 24833871 LncRNADisease
EL0556 H19 coronary artery disease N/A N/A N/A N/A Re-expression of H19 has been observed in patients with atherosclerosis. Common polymorphisms of H19 are associated with the risk and severity of CAD in a Chinese population. 25772106 LncRNADisease
EL0556 H19 Beckwith-Wiedemann syndrome N/A N/A N/A epigenetics Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome. 7987305 LncRNADisease
EL0556 H19 cervical cancer N/A N/A N/A mutation High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. 8570220 LncRNADisease
EL0556 H19 breast adenocarcinomas N/A breast adenocarcinoma stromal cells up-regulated expression An up-regulation of the h19 gene is significantly correlated with the tumor values and the presence of both estrogen and progesterone receptors 9811352
EL0556 H19 bladder cancer PCR-RFLP etc. blood differential expression mutation A significantly decreased risk of bladder cancer was found for the rs2839698 TC genotype but not for CC homozygotes.The rs2839698 TC genotype was especially associated with a reduced risk of developing non-muscle-invasive disease. Borderline significantly 18262338 LncRNADisease Lnc2Cancer
EL0556 H19 meningioma qPCR etc. meningioma tissue differential expression N/A In total, 24 meningiomas of WHO grade I, II and III were analysed. 15 meningiomas (63%) were informative for the ApaI polymorphism in the IGF2 gene. Monoallelic expression (MAE) for IGF2 was found in 11 out of 15 tumours (73%) which is in contrast to the lack of imprinting status of IGF2 in leptomeninges. Ten cases (42%) were heterozygous for the H19 gene and biallelic expression was found in 3 out of 10 meningiomas (30%). These results indicate that modulation of the imprinting status of IGF2 and H19 may play an important role for the development of meningiomas. 10738131 Lnc2Cancer
EL0556 H19 colorectal cancer qPCR etc. CRC tissue up-regulated N/A LOI of IGF2 correlated strongly with biallelic hypermethylation of a core of five CpG sites in the insulator region of IGF2/H19, which is a known CTCF-binding element. As this methylation-dependent LOI was present in both tumors and normal colonic mucosa, it is possible that hypermethylation creates a field defect predisposing to cancer. 11120891 Lnc2Cancer
EL0556 H19 germ cell tumor qPCR etc. germ cell tumor tissue differential expression epigenetics IGF2/H19 methylation status in GCTs might reflect preservation of the physiologic imprinting erasure in PGCs rather than a loss of imprinting in a sense that is accepted for somatic tumors. 16001432 LncRNADisease Lnc2Cancer
EL0556 H19 breast cancer qPCR etc. cell lines (MCF10A, RPMI 1640, DMEM H21 etc.) up-regulated expression Down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas. 16707459 LncRNADisease Lnc2Cancer
EL0556 H19 lung cancer qPCR etc. cell lines (MCF10A, RPMI 1640, DMEM H21 etc.) up-regulated expression Down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas. 16707459 LncRNADisease Lnc2Cancer
EL0556 H19 breast cancer qPCR etc. breast cancer tissue differential expression mutation rs2107425 (C>T) near H19 was significantly associated with shorter metastasis-free survival in uni- and multi-variate analysis , with the more aggressive minor allele displaying a recessive trait. 21748294 LncRNADisease Lnc2Cancer
EL0556 H19 gastric cancer qPCR etc. gastric cancer tissue, cell lines (HGC27) up-regulated N/A Plasma H19 levels were significantly higher in patients than in healthy controls (p=0.029). Circulating lncRNAs can be detectable in plasma, and the detection of circulating lncRNAs may provide new complementary tumor markers for gastric cancer. 23898077 Lnc2Cancer
EL0556 H19 hepatocelluar carcinoma qPCR etc. cell lines (SMMC-7721, HepG2) up-regulated N/A Comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). 24063685 Lnc2Cancer
EL0556 H19 prostate cancer qPCR etc. cell lines ((Du-145, PC-3) down-regulated N/A Comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). 24063685 Lnc2Cancer
EL0556 H19 lung cancer qPCR etc. cell lines (A549) down-regulated N/A Comparing with respective normal cell line, H19 was found highly expressed in stomach cancer cell lines (AGS, MGC-803 and SGC-7901) and hepatocellular carcinoma cell lines (SMMC-7721 and HepG2), while lowly expressed in lung cancer cell line (A549) and prostate cancer cell lines (Du-145 and PC-3). 24063685 Lnc2Cancer
EL0556 H19 gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression After validating in 20 pairs of tissues and plasma in training set, H19 was selected for further analysis in another 70 patients and 70 controls. Plasma level of H19 was significantly higher in GC patients compared with normal controls. 26096073 Lnc2Cancer
EL0556 H19 liver cancer qPCR etc. hepatocellular carcinoma tissue up-regulated expression LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes.Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. 26272696 Lnc2Cancer
EL0556 H19 medulloblastoma qPCR etc. fetal cerebella tissue, cell lines (MEB-MED, D283 etc.) differential expression expression Loss of imprinting of H19 occurred in 0 out of 4 informative fetal cerebella, 0 out of 1 informative adult cerebellum, 4 out of 8 informative medulloblastomas, and 1 out of 4 informative cell lines. The biallelic expression of H19 was only partial in two medulloblastomas, however, with one allele being significantly weaker than the other. 8957451 Lnc2Cancer
EL0556 H19 breast cancer qPCR, ISH etc. MDA-MB-231 cell line up-regulated expression Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. 12419837 LncRNADisease Lnc2Cancer
EL0556 H19 bladder cancer qPCR, ISH etc. cell lines (T24P, HT-1376 etc.) up-regulated N/A Bladder tumors may be successfully treated by intravesical instillation of the double promoter vector H19-DTA-P4-DTA. 21162716 LncRNADisease Lnc2Cancer
EL0556 H19 breast cancer qPCR, knockdown etc. breast cancer tissue, cell lines (MCF7, T47D, BT20 etc.) up-regulated expression the transcript is stabilized in breast cancer cells and overexpressed in human breast tumors.91H expression is upregulated in breast cancer. 18794369 LncRNADisease Lnc2Cancer
EL0556 H19 ovarian cancer qPCR, knockdown etc. cell lines (PC3, C2C12 etc.) up-regulated expression H19 RNA was detected in 90% of patients with OCAF (Ovarian cancer ascites fluid ) as determined by ISH. Intratumoral injection of DTA-H19 into ectopically developed tumors caused 40% inhibition of tumor growth. 19656414 LncRNADisease Lnc2Cancer
EL0556 H19 gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines MGC-803, SGC-7901, GES-1) up-regulated regulation c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. 24671855 LncRNADisease Lnc2Cancer
EL0556 H19 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (TE-1 ,Eca-109) down-regulated regulation Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. 24706416 LncRNADisease Lnc2Cancer
EL0556 H19 colorectal cancer qPCR, knockdown etc. CRC tissue, cell lines ( HCT8, HT29, HCT116, SW620 etc.) up-regulated regulation 91H was significantly overexpressed in cancerous tissue and CRC cell lines compared with adjacent normal tissue and a normal human intestinal epithelial cell line. Moreover, 91H overexpression was closely associated with distant metastasis and poor prognosis in patients with CRC, except for CNV of 91H. Multivariate analysis indicated that 91H expression was an independent prognostic indicator, as well as distant metastasis. 91H played an important role in the molecular etiology of CRC and might be regarded as a novel prognosis indicator in patients with CRC. 25058480 Lnc2Cancer
EL0556 H19 skin cancer qPCR, lncRNA array analysis cultured mouse keratinocytes after deleting the vitamin D receptor (VDR) (∼90%) vs. control cells up-regulated expression Several well-known oncogenes, including H19, HOTTIP and Nespas, are significantly increased (6.3-1.8-fold), whereas tumor suppressors (Kcnq1ot1, lincRNA-p21) are decreased (up to 50-70%) in VDR deleted keratinocytes. 24342142
EL0556 H19 bladder cancer qPCR, Luciferase reporter assay, in vitro knockdown, RIP etc. bladder cancer tissue, cell lines (RT4, RT112, DSH1, 253J, TCCSUP etc.) up-regulated regulation Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. 23354591 LncRNADisease Lnc2Cancer
EL0556 H19 gastric cancer qPCR, Luciferase reporter assays, in vitro knockdown, RIP etc. gastric cancer tissue,cell lines (AGS, MKN45, MGC803, SGC7901, GES-1 etc.) up-regulated N/A We demonstrated that H19 levels were markedly increased in gastric cancer cells and gastric cancer tissues compared with normal controls. Moreover, ectopic expression of H19 increased cell proliferation, whereas H19 siRNA treatment contributed to cell apoptosis in AGS cell line. We further verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation. 22776265 Lnc2Cancer
EL0556 H19 gastric cancer qPCR, Luciferase reporter assays, knockdown etc. gastric cancer tissue up-regulated interaction H19 expression was found to be inversely correlated to miR-141 expression in gastric cancer cells and tissues. H19 promotes malignancy including proliferation and invasion whereas miR-141 suppresses malignancy in human cancer cells. MiR-141 binds to H19 in a sequence specific manner, and suppresses H19 expression and functions including proliferation and invasion. MiR-141 could also regulate H19 target genes and miR-141 inhibitor restores H19 siRNA function, while H19 regulates miR-141 target gene ZEB1 26160158 Lnc2Cancer
EL0556 H19 non-small cell lung cancer qPCR, Luciferase reporter assays, knockdown, ChIP etc. NSCLC cell lines (A549, SPCA1) up-regulated interaction The higher expression of H19 was positively correlated with advanced tumor-node-metastasis (TNM) stage and tumor size. Multivariate analyses found that H19 expression could serve as an independent prognostic factor for overall survival of NSCLC. Moreover, chromatin immunoprecipitation (ChIP) assays revealed that H19 was a direct transcriptional target of c-Myc. And, knockdown of H19 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. 26482621 Lnc2Cancer
EL0556 H19 glioblastoma qPCR, Neurosphere Formation assay etc. glioblastoma tissue, cell lines (U87, U373) up-regulated expression H19 is significantly overexpressed in glioblastoma tissues, and the level of expression was associated with patient survival. In the subsequent investigations, the authors found that overexpression of H19 promotes glioblastoma cell invasion and angiogenesis in vitro. Interestingly, H19 was also significantly overexpressed in CD133+ glioblastoma cells, and overexpression of H19 was associated with increased neurosphere formation of glioblastoma cells. 26274999 Lnc2Cancer
EL0556 H19 breast cancer qPCR, Northern blot etc. breast cancer tissue differential expression expression H19 RNA and insulin-like growth factor II mRNA were up-regulated significantly in non-neoplastic WAP-CRD-BP mammary tissue. 14729626 LncRNADisease Lnc2Cancer
EL0556 H19 colon cancer qPCR, Northern blot, ISH etc. CRC tissue up-regulated locus Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. 19926638 LncRNADisease Lnc2Cancer
EL0556 H19 colorectal cancer qPCR, RFLP-PCR etc. CRC tissue up-regulated N/A The results of the present study suggest that LOI of IGF2 is important in the carcinogenesis of CRC. Hypomethylation of the sixth CTCF-binding site in the DMR of IGF2/H19 is linked to LOI and the common IGF2-H19 enhancer competition model for IGF2 imprinting does not apply to human CRC. 22427002 Lnc2Cancer
EL0556 H19 bladder cancer qPCR, Western blot etc. bladder cancer tissue, cell lines (RT4, RT112, DSH1, 253J, TCCSUP etc.) up-regulated regulation Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. 23399020 LncRNADisease Lnc2Cancer
EL0556 H19 chronic myeloid leukemia qPCR, Western blot etc. cell lines (K562) up-regulated N/A We observed that H19 was highly expressed in Bcr-Abl-expressing primary CML cells derived from 4 patients, and imatinib treatment greatly decreased the expression of H19 in these cells but not in normal control cells. Loss of either Bcr-Abl expression or Abl kinase activity caused decrease of c-Myc levels with simultaneously reduced levels of H19. Furthermore, we demonstrated that depletion of c-Myc alone in K562 cells significantly decreased the level of H19, suggesting that H19 is expressed in a c-Myc dependent manner in K562 leukemic cells. 24685695 Lnc2Cancer
EL0556 H19 prostate cancer qPCR, Western blot etc. cell lines (P69, M12) down-regulated N/A In this study, we found that long non-coding RNA H19 (H19) and H19-derived microRNA-675 (miR-675) were significantly downregulated in the metastatic prostate cancer cell line M12 compared with the non-metastatic prostate epithelial cell line P69. Upregulation of H19 in P69 and PC3 cells significantly increased the level of miR-675 and repressed cell migration; however, ectopic expression of H19 in M12 cells could not increase the level of miR-675 and therefore had no effect on cell migration. 24988946 Lnc2Cancer
EL0556 H19 bladder cancer qPCR, Western blot etc. bladder cancer tissue, cell lines (5637, UMUC-3, EJ) up-regulated interaction YAP1 and H19 expression levels were markedly elevated in bladder cancer tissues and cells, and H19 expression was found to be significantly associated with YAP1 expression. YAP1 and H19 were overexpressed were associated with poorer clinicopathologic prognosis. In addition, YAP1 was found to enhance H19 expression, whereas H19 had no significant effect on YAP1 expression in bladder cancer cells. 26163939 Lnc2Cancer
EL0556 H19 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (AGS, MGC803 etc.) up-regulated N/A The expression levels of H19 and miR-675 in five gastric cancer cell lines were correlated with each other (r = 0.9910, P = 0.0315, data not shown). We next assessed the correlation of miR-675 and H19 expression in 24 human gastric cancer tissues. The expression of H19 and miR-675 in gastric cancer tissues was correlated with each other (r = 0.8214, P < 0.01). 24388988 Lnc2Cancer
EL0556 H19 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (HepG2) up-regulated N/A We found that AFB1 could up-regulate the expression of H19 and promote cell growth and invasion by hepatocellular carcinoma HepG2 cells. AFB1 induced the expression of E2F1 and its knock-down could down-regulate H19 expression and suppress cell growth and invasion in hepatocellular carcinoma HepG2 cells. E2F1 over-expression could up-regulate H19 expression and promote cell growth and invasion, with binding to the H19 promoter being demonstrated by chromatin immunoprecipitation assays. 24761865 Lnc2Cancer
EL0556 H19 pancreatic ductal adenocarcinoma qPCR, Western blot, knockdown etc. pancreatic cancer tissue, cell lines (PANC-1, SW1990, AsPC-1, BxPC-3, CFPAC-1 etc.) up-regulated N/A The levels of H19 was overexpressed in PDAC and was upregulated remarkably in primary tumors which subsequently metastasized, compared to those did not metastasis. H19 promoted PDAC cell invasion and migration. An important role of H19 in regulating metastasis of PDAC and provides some clues for elucidating the lncRNAmiRNA functional network in cancer. 24920070 Lnc2Cancer
EL0556 H19 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (Huh-7, MHCC-97H, HepG2 etc.) up-regulated N/A The expression levels of LncRNAH19 and miR-675 were higher in MHCC-97H cells than in L02, Huh-7 and HepG2 cells. Transwell migration assay revealed that the miR-675 inhibitor and LncRNAH19siRNA could significantly increase the migration of HCC cells as compared with the control group. Transwell invasion assay demonstrated that the miR-675 inhibitor and LncRNAH19siRNA could significantly increase the invasion of HCC cells as compared with the control group. Inhibition of LncRNAH19 and miR-675 expression can promote migration and invasion of HCC cells via AKT/GSK-3β/Cdc25A signaling pathway. 24939300 Lnc2Cancer
EL0556 H19 breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue, cell lines (MCF-7, MDA-MB-231) up-regulated N/A H19 lncRNA mediates 17beta-estradiol-induced cell proliferation in MCF-7 breast cancer cells; H19 lncRNA was much higher in estrogen receptor (ER)-positive MCF-7 breast cancer cells than in ER-negative MDA-MB-231 cells 25846769 LncRNADisease Lnc2Cancer
EL0556 H19 esophageal cancer qPCR, Western blot, knockdown etc. esophageal cancer tissue, cell lines (TE-1, TE-10, Eca-1, Eca-109, KYSE1170) up-regulated expression The expression of H19 was significantly increased and associated with tumor depth and metastasis in 133 EC samples. In addition, it was identified that an upregulation of H19 induced epithelial-to-mesenchymal transition. In conclusion, H19 has a significant role in the development of EC and may serve as a potential prognostic marker and therapeutic target for EC. 26171017 Lnc2Cancer
EL0556 H19 ovarian cancer qPCR, Western blot, knockdown etc. ovarian cancer tissues and adjacent normal tissues, cell lines (SKOV3, OV90, TOV112D, ES2) up-regulated expression Our results demonstrated that that H19 silencing inhibited OV90 and SKOV3 OC cell proliferation in vitro. Further investigation into the mechanisms responsible for the growth inhibitory effects by H19 silencing revealed that its knockdown resulted in the induction of cell cycle arrest and apoptosis through certain cell cycle-related and apoptosis-related proteins 26617715 Lnc2Cancer
EL0556 H19 colorectal cancer qPCR, Western blot, Luciferase reporter assay, RIP etc. CRC tissue, cell lines (SW620, HCT-116) up-regulated interaction We found that H19 was highly expressed in mesenchymal-like cancer cells and primary CRC tissues. H19 modulated the expression of multiple genes involved in EMT by acting as a competing endogenous RNA, which may build up the missing link between the regulatory miRNA network, EMT progression and accelerates in vivo and in vitro tumor growth. 26068968 Lnc2Cancer
EL0556 H19 gastric cancer qPCR, Western blot, Luciferase reporter assays, knockdown etc. gastric cancer tissue, cell lines (SGC7901, MKN45, MKN-28 etc.) up-regulated expression Overexpression of?lncRNA?H19 enhances carcinogenesis and metastasis of gastric cancer. 24810858 LncRNADisease Lnc2Cancer
EL0556 H19 bladder cancer qPCR, Western blot, Luciferase reporter assays, knockdown etc. bladder cancer tissues, cell lines (RT4, HT-1376, 5637, 253J, TCCSUP, T24,and J82) up-regulated interaction We found that miR-675 expression levels were remarkably increased in bladder cancer tissues as compared with adjacent noncancerous tissues or normal bladder tissue from health donors; moreover, enhanced miR-675 expression was also observed in bladder cancer cell lines. Ectopic expression of H19 significantly increased bladder cancer cell proliferation and miR-675 expression in vitro 26198047 Lnc2Cancer
EL0556 H19 hepatocelluar carcinoma qPCR, Western bolt, Northern bolt, in vitro knockdown, RIP etc. HCC tissue, cell lines(SMMC7721, HCCLM3) down-regulated regulation Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma. 23222811 LncRNADisease Lnc2Cancer
EL0556 H19 clear cell renal cell carcinoma qRT-PCR, siRNA clear cell renal carcinoma (ccRCC) tissues and renal cancer cell lines up-regulated expression lncRNA H19 might be considered as a potential prognostic indicator and a target for gene therapy of ccRCC. 25866221
EL0556 H19 gastric cancer real-time quantitative polymerase chain reaction (qPCR) assay gastric cancer (GC) tissues up-regulated expression H19 might serve as a promising biomarker for early detection and prognosis prediction of GC. 26774144
EL0556 H19 breast cancer RNA CISH etc. breast cancer tissue up-regulated expression HOTAIR, H19 and KCNQ1OT1 had significantly higher expression levels in IBC than NA, and HOTAIR and H19 were both expressed more strongly in IBC than in DCIS tissues. 26323944 Lnc2Cancer
EL0556 H19 non-small cell lung cancer RT-PCR, luciferase reporter assay, Chromosome immune coprecipitation (ChIP), disturbing and overexpressing the expression of H19, flow cytometry NSCLC tissues and cells, the adjacent tissues and normal cells up-regulated interaction lncRNA H19, which is induced by c-Myc, is up-regulated in NSCLC. H19 influences the mitotic progression of NSCLC cell lines. 26722426
EL0556 H19 Wilms' tumor Southern blot, Northern blot etc. Wilms' tumor tissue differential expression epigenetics Gain of methylation at the H19 DMR is an early event in Wilms' tumorigenesis that is independent of chromosomal losses. 16179496 LncRNADisease Lnc2Cancer
EL0556 H19 gastric cancer stratified analyses gastric cancer samples up-regulated mutation We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs)(rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC. 25944697
EL0557 HA117 hirschsprung disease N/A N/A N/A N/A HA117 expression in stenotic segment was higher compared to proximal anastomosis and dilated segment (p < 0.05); HA117 may be a factor exerting an anti-differentiation or anti-maturation role in the genesis of HSCR. 25120773 LncRNADisease
EL0558 HAGLR neuroblastoma microarray, qPCR, Northern blot, knockdown etc. cell lines (SH-SY5Y) up-regulated regulation One of these lncRNAs, termed HOXD-AS1, is encoded in HOXD cluster. HOXD-AS1 is overexpressed in neuroblastoma. We found that HOXD-AS1 is a subjetc to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation. Knock-down experiments revealed that HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer. 25522241 Lnc2Cancer
EL0559 HAGLROS papillary thyroid carcinoma microarrays, CCK-9 assay, colony formation assay and EdU assay, Flow Cytometry, Transwell and scratch assay Papillary thyroid cancer cell line N/A expression lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. lncRNAs (ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis. ENST00000426615 could inhibit the cell motility 26824456
EL0561 HAR1A Huntington's disease N/A N/A N/A expression HAR1, a deeply conserved genomic region consisting of a cis-antisense pair of structured lncRNAs (HAR1F and HAR1R) (2, 23) located ~80 kb from the neural microRNA, miR-124-3. HAR1 levels are significantly lower in the striatum of HD patients. 20179156 LncRNADisease
EL0561 HAR1A Alzheimer's disease N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
EL0561 HAR1A schizophrenia N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
EL0561 HAR1A Huntington's disease N/A N/A N/A regulation HAR1 has also been implicated in HD, where the transcriptional repressor RE-1-silencing transcription factor (REST) enters pathologically into the nucleus, leading to the repression of several important neuronal genes. 23562612 LncRNADisease
EL0562 HAR1B Huntington's disease N/A N/A N/A expression HAR1, a deeply conserved genomic region consisting of a cis-antisense pair of structured lncRNAs (HAR1F and HAR1R) (2, 23) located ~80 kb from the neural microRNA, miR-124-3. HAR1 levels are significantly lower in the striatum of HD patients. 20179156 LncRNADisease
EL0562 HAR1B Alzheimer's disease N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
EL0562 HAR1B schizophrenia N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
EL0562 HAR1B Huntington's disease N/A N/A N/A regulation HAR1 has also been implicated in HD, where the transcriptional repressor RE-1-silencing transcription factor (REST) enters pathologically into the nucleus, leading to the repression of several important neuronal genes. 23562612 LncRNADisease
EL0564 HCP5 AIDS N/A N/A N/A mutation HCP5 genotyping could serve as a simple screening tool for ABC-HSR. 18684101 LncRNADisease
EL0564 HCP5 AIDS N/A N/A N/A mutation A polymorphism (rs2395029, G824T) in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. 19935381 LncRNADisease
EL0564 HCP5 AIDS N/A N/A N/A expression A total of 245 HIV patients were included in the study. A good correlation between HLA-B*5701 and HCP5 was observed (negative and positive predictive values of 100% and 93%, respectively). 20534626 LncRNADisease
EL0565 HEIH hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue, cell lines (Huh7, HepG2) up-regulated N/A The transcript levels of lncRNA-HEIH were higher in HCC tissues (p=0.010) when compared with the corresponding non-tumor liver tissues from the same donor. And we found that patients with high lncRNA-HEIH expression in HCC had significantly worse prognosis than those with low lncRNA-HEIH expression. 21769904 Lnc2Cancer
EL0565 HEIH hepatocelluar carcinoma N/A N/A N/A expression Dr. Yang and his colleagues found that one lncRNA, named lncRNA-HEIH, was overexpressed in HCC tissue compared with normal liver tissues using microarray. 24757675 LncRNADisease
EL0565 HEIH hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (MHCC97L, HepG2, cHL-7702) up-regulated expression The expression of HEIH and HULC in hepatocellular carcinoma cell line was significantly increased compared with human normal hepatocyte line (P<0.05). The expression of HULC in HepG2 was higher than that in MHCC97L. The over-expression of HULC could enhance proliferation of MHCC97L and HepG2, however, the over-expression of HEIH could not. The over-expression of HULC and HEIH could promote invasion of MHCC97L and HepG2. Invasion of MHCC97L and HepG2 did not have significant change after down-regulating of HEIH and HULC by siRNA. Over-expression of HULC up-regulated the expression of Snail in HepG2. 26550214 Lnc2Cancer
EL0567 HELLS hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We noted that LINC01419 was characterized by a significant increase in transcript expression from dysplasia to early HCC. The lncRNA AK021443 was also up-regulated in advanced HCC samples when compared with early HCC. Moreover, expression of LINC01419 and AK021443 was up-regulated in HCC tissues when compared with non-tumor liver tissue. AF070632 expression was down-regulated in HCC and was decreased in advanced HCC when compared with early HCC. These results suggest that LINC01419 may be related to the initiation of HCC, whereas AK021443 and AF070632 may be associated with the progression of HCC. 26540467 Lnc2Cancer
EL0569 HIF1A-AS1 kidney cancer N/A N/A N/A expression Diagnostic and discriminative marker 24373479 LncRNADisease
EL0569 HIF1A-AS1 Cardiovascular disease N/A N/A N/A N/A Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro. 25761653 LncRNADisease
EL0569 HIF1A-AS1 kidney cancer qPCR etc. renal cancer tissue up-regulated expression The antitumor DNA topoisomerase I (Top1) inhibitor camptothecin (CPT) increases the cellular levels of two antisense lncRNAs at the 5' (5'aHIF-1 alpha) and 3' (3'aHIF-1 alpha) ends of the human HIF1A-AS1 gene. 21897117 LncRNADisease Lnc2Cancer
EL0569 HIF1A-AS1 non-small cell lung cancer qPCR etc. blood (serum), NSCLC tissue up-regulated expression The levels of XIST (P < 0.05) and HIF1A-AS1 (P < 0.05) were significantly increased in tumor tissues or serum from NSCLC patients as compared to those of control group. Moreover, serum levels of XIST and HIF1A-AS1 were significantly decreased after surgical treatment as compared to pre-operative. 26339353 Lnc2Cancer
EL0569 HIF1A-AS1 aneurysm of the thoracoabdominal aorta RT-PCR VSMCs, serum of TAA patients up-regulated expression HIF1a-AS1 was overexpressed in the thoracoabdominal aorta aneurysm and the interaction between HIF1a-AS1 and apoptotic proteins plays a key role in the proliferation and apoptosis of VSMCs in vitro, which may contribute to the pathogenesis of thoracoabdominal aorta aneurysm. 25550800
EL0570 HIF1A-AS2 osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue up-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0570 HIF1A-AS2 kidney cancer N/A N/A N/A expression Diagnostic and discriminative marker 24373479 LncRNADisease
EL0570 HIF1A-AS2 acute myocardial infarction N/A N/A N/A N/A Level of hypoxia inducible factor 1A antisense RNA 2 was higher in patients with MI than in healthy volunteers (P<0.01) 25035150 LncRNADisease
EL0570 HIF1A-AS2 gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression The expression of HIF1A-AS2 was upregulated in GC tumorous tissues compared with the adjacent normal tissues (P < 0.001). Its overexpression was correlated with TNM stages (P = 0.008), tumor invasion (P = 0.016), lymph node metastasis (P = 0.042), and poor prognosis (P = 0.001). 25686741 Lnc2Cancer
EL0570 HIF1A-AS2 renal cancer qPCR etc. renal cancer tissue up-regulated expression overexpressed in human renal cancer and during hypoxia. 9923855 LncRNADisease Lnc2Cancer
EL0570 HIF1A-AS2 bladder cancer SV-HUC-1 cells bladder cancer tissue and cells up-regulated N/A Overexpression of HIF1A-AS2 in SV-HUC-1 cells could promote cell proliferation cell migration and anti-apoptosis 27018306
EL0571 HIF2PUT colorectal cancer N/A colorectal cancer (CRC) tissues N/A interaction LncRNA-HIF2PUT small interfering RNA transfection resulted in decreased stemness genes expression, impaired colony formation, and spheroid formation ability, retarded migration, and invasion of the cells. 26648739
EL0571 HIF2PUT osteosarcoma qPCR, knockdown etc. osteosarcoma tissue, cell lines (SAOS2, MG63, U2OS) differential expression expression HIF2PUT expression levels were positively correlated with HIF-2a in osteosarcoma tissues. Overexpression of HIF2PUT markedly inhibited cell proliferation and migration, decreased the percentage of CD133 expressing cells, and impaired the osteosarcoma stem sphere-forming ability of the MG63 cells. Furthermore, altering the expression of HIF2PUT resulted in a concomitant change to HIF-2a mRNA expression. 25434862 Lnc2Cancer
EL0572 HIV1230 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue down-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL0573 HLA-AS1 psoriasis N/A N/A N/A mutation HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3. 15848982 LncRNADisease
EL0573 HLA-AS1 multiple sclerosis N/A N/A N/A mutation We identified significant effects on MS susceptibility of HLA-A*2 , and two coding polymorphisms in the MOG gene after full conditioning on HLA-DRB1. 17971048 LncRNADisease
EL0573 HLA-AS1 AIDS N/A N/A N/A mutation HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. 18982067 LncRNADisease
EL0573 HLA-AS1 liver injury N/A N/A N/A mutation HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. 19483685 LncRNADisease
EL0575 HNF1A-AS1 nasopharyngeal carcinoma knockdown, colony-formation, wound-healing, and transwell assays, cell cycle analysis, western blot analysis tumor tissues from 20 patients with nasopharyngeal carcinoma (NPC) as well as from cultured NPC cell lines N/A expression LncRNA, HNF1A-AS potentially regulates NPC tumorigenesis. HNF1A-AS was found to be associated with epithelial to mesenchymal transition. 26756620
EL0575 HNF1A-AS1 gastric cancer microarray, qPCR etc. GC tissue, cell lines (AGS, BGC-823, MKN-45) down-regulated interaction LncRNAs microarray analysis results exhibited that HNF1A-AS1 was downregulated in GCs tissues (mean fold change 2.06, p < 0.05), which was further confirmed by qRT-PCR. The results from qRT-PCR showed that the expression of HNF1A-AS1 was not only downregulated in three GC cell lines (AGS, BGC-823, and MKN-45) relative to that in a normal gastric mucosal epithelial cell line (GES-1), but also decreased in GC tissues relative to that in paired adjacent non-neoplastic tissues (low expression, 94 of 161; low expression rate, 58.38%). Furthermore, low HNF1A-AS1 expression was associated with tumor size/diameter (p = 0.005, multivariate analysis), levels of serum carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), and RRM1 expression in tissue samples 26472090 Lnc2Cancer
EL0575 HNF1A-AS1 esophageal adenocarcinoma microarray, RNA-seq, qPCR, Western bolt, knockdown etc. esophageal adenocarcinoma tissue, cell lines (HEEpiC, SKGT-4, OE33 etc.) up-regulated regulation Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. 24000294 LncRNADisease Lnc2Cancer
EL0575 HNF1A-AS1 hepatocellular carcinoma N/A HCC tissue and cell line up-regulated N/A sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2 27084450
EL0575 HNF1A-AS1 esophageal squamous cell carcinoma qPCR etc. blood (plasma and serum) up-regulated expression Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. 25608466 Lnc2Cancer
EL0575 HNF1A-AS1 lung adenocarcinoma qPCR, Western blot, knockdown, RIP etc. lung adenocarcinoma tissue, cell lines (A549, SPC-A1, H1650) up-regulated interaction HNF1A-AS1 was significantly up-regulated in lung adenocarcinoma tissues compared with corresponding non-tumor tissues, and its expression level was significantly correlated with TNM stage, tumor size, and lymph node metastasis. Moreover, HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and β-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. 25863539 Lnc2Cancer
EL0577 HOST2 epithelial ovarian cancer qPCR, Western blot etc. ovarian cancer tissue, cells lines (OVCAR3) up-regulated N/A EOC-specific lncRNA-HOST2, which acts as a miRNA sponge, sequesters let-7b to maintain the expression of oncogenes and further maintains EOC biological functions. 25292198 LncRNADisease Lnc2Cancer
EL0578 HOTAIR nasopharyngeal carcinoma knockdown nasopharyngeal carcinoma cells up-regulated interaction Hotair knockdown significantly attenuated both in vitro and in vivo tumor cell growth and angiogenesis. 26717040
EL0578 HOTAIR esophageal squamous cell carcinoma lncRNA microarray, qRT-PCT esophageal squamous cell carcinoma (ESCC) tissue up-regulated expression ESCCAL_1 and HOTAIR may participate in the pathological process of ESCC. Furthermore, lncRNA could be potential diagnostic and prognostic biomarkers for ESCC. 25297587
EL0578 HOTAIR prostate cancer microarray, qPCR etc. prostate cancer tissue, cell lines (LNCaP, PC3, DU145, RWPE-1 etc.) up-regulated N/A LncRNA profiling showed that HOTAIR was highly regulated by genistein and its expression was higher in castration-resistant PCa cell lines than in normal prostate cells. Knockdown (siRNA) of HOTAIR decreased PCa cell proliferation, migration and invasion and induced apoptosis and cell cycle arrest. miR-34a was also up-regulated by genistein and may directly target HOTAIR in both PC3 and DU145 PCa cells. Our results indicated that genistein inhibited PCa cell growth through down-regulation of oncogenic HOTAIR that is also targeted by tumor suppressor miR-34a. These findings enhance understanding of how genistein regulates lncRNA HOTAIR and miR-34a in PCa. 23936419 Lnc2Cancer
EL0578 HOTAIR esophageal squamous cell carcinoma microarray, qPCR etc. ESCC tissue up-regulated expression Expression of HOTAIR lncRNA is increased in various cancers, and it is also significantly increased in our analysis of ESCC. 24222893 LncRNADisease Lnc2Cancer
EL0578 HOTAIR non-functioning pituitary adenoma microarray, qPCR etc. NFPA tissue up-regulated expression Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. 24469926 LncRNADisease Lnc2Cancer
EL0578 HOTAIR colorectal cancer microarray, qPCR etc. CRC tissue up-regulated regulation Two of the lncRNAs, HOTAIR and a novel lncRNA, lncRNA-422 were confirmed in more samples. GSEA indicated that gene sets most correlated with them were those named up-regulated in KRAS-over, down-regulated in JAK2-knockout, down-regulated in PDGF-over and down-regulated in TBK1-knockout, all of which were cancer-related. Subsequently, GO analyses of most significantly correlated coding genes of HOTAIR and lncRNA-422 showed that these two lncRNAs may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer. 25456707 Lnc2Cancer
EL0578 HOTAIR triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
EL0578 HOTAIR papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. 25997963 Lnc2Cancer
EL0578 HOTAIR gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) up-regulated expression H19 and HOTAIR displayed significantly higher levels and the up-regulation of HOTAIR was associated with lymphatic metastasis and poor differentiation. 26237576 Lnc2Cancer
EL0578 HOTAIR breast cancer microarray, qPCR, ISH etc. breast tumor tissue up-regulated N/A Co-expression of HOTAIR and EZH2 trended with a worse outcome. In matched primary and metastatic cancers, both HOTAIR and EZH2 had increased expression in the metastatic carcinomas. This approach offers a method to make observations on lncRNAs that may influence the cancer epigenome in a tissue-based technique. 23133536 Lnc2Cancer
EL0578 HOTAIR hepatocelluar carcinoma microarray, qPCR, knockdown, Western blot etc. cell lines (HepG2 ,Bel-7402) up-regulated regulation Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. 24663081 LncRNADisease Lnc2Cancer
EL0578 HOTAIR cervical cancer microarray, qPCR, RIP etc. cervical cancer tissue, cell line (C33-A) down-regulated interaction We identified significant linear trend of progressive HOTAIR down-regulation through HPV negative controls, HPV16 positive non-malignants and CaCx samples. Majority of CaCx cases portrayed HOTAIR down-regulation in comparison to HPV negative controls, with corresponding up-regulation of HOTAIR target, HOXD10, and enrichment of cancer related pathways. However, a small subset had significantly higher HOTAIR expression, concomitant with high E7 expression and enrichment of metastatic pathways. Expression of HOTAIR and PRC2-complex members (EZH2 and SUZ12), showed significant positive correlation with E7 expression in CaCx cases and E7 transfected C33A cell line, suggestive of interplay between E7 and HOTAIR. 26152361 Lnc2Cancer
EL0578 HOTAIR esophageal squamous cell carcinoma microarray, qPCR, Western blot, knockdown etc. ESCC tissue, cell lines (KYSE30, KYSE140, KYSE180, KYSE410, KYSE510) up-regulated N/A It was found that there was a great upregulation of HOTAIR in ESCC compared to their adjacent normal esophageal tissues. Meanwhile, patients with high HOTAIR expression have a significantly poorer prognosis than those with low expression. Moreover, HOTAIR was further validated to promote migration and invasion of ESCC cells in vitro. 24118380 Lnc2Cancer
EL0578 HOTAIR glioma microarray, Western blot etc. glioblastoma tissue up-regulated N/A HOTAIR expression was significantly higher in HGG than in low-grade glioma (LGG; P < .001). Moreover, as shown in Fig. 1A, GBM demonstrated a significant increase in HOTAIR transcript levels, compared with that observed in normal tissues (P = .093), LGGs (P < .001), or AGs (P = .011). Our data establish that HOTAIR serves as a prognostic factor for glioma patient survival, as well as a biomarker for identifying glioma molecular subtypes, a critical regulator of cell cycle progression. 24203894 Lnc2Cancer
EL0578 HOTAIR ovarian cancer monitored double-strand breaks recurrent platinum-resistant ovarian tumors vs primary ovarian tumors N/A N/A HOTAIR expression results in sustained activation of DNA damage response (DDR) after platinum treatment; HOTAIR regulates activation of NF-κB 27041570
EL0578 HOTAIR gastric cancer N/A gastric cancer cell lines and tissue samples up-regulated locus/expression We found that the HOTAIR rs920778 TT carriers had a 1.66- and 1.87-fold increased gastric cancer risk in Jinan and Huaian populations compared with the CC carriers. 25640751
EL0578 HOTAIR triple-negative breast cancer N/A Triple-negative breast cancer (TNBC) samples up-regulated expression HOTAIR has been known to induce tumor growth and metastasis in breast cancer. Depleting HOTAIR alone phenocopies the dual treatment in growth suppression. We show that expression of HOTAIR is regulated by β-catenin through a LEF1/TCF4-binding site. 25883211
EL0578 HOTAIR LPS-induced sepsis N/A cardiomyocytes from sepsis mice up-regulated interaction HOTAIR silence preserved cardiac function of sepsis mice during LPS-induced sepsis. 26806307
EL0578 HOTAIR Temporomandibular joint osteoarthritis N/A the synovial fluid of TMJ OA patients up-regulated N/A knockdown of HOTAIR in IL-1β-induced TMJ OA in vitro 27063559
EL0578 HOTAIR breast cancer N/A N/A N/A expression HOTAIR showed positive association with 'hang Serum Response'. 19182780 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression A subsequent study revealed that HOTAIR is overexpressed in approximately one quarter of human breast cancers. 20930520 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A epigenetics Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. 21256239 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression The lncRNA HOTAIR is a strong predictor of metastasis in breast tumors and its over-expression in various breast carcinoma cell lines promotes invasion. 21903344 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression Elevated expression of HOTAIR is observed in primary and metastatic breast cancer. 21925379 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A expression HOTAIR is causally involved in tumor progression. It is significantly overexpressed in metastatic breast cancer. 22045689 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A regulation On a more mechanistic level, recent studies have revealed the contribution of lncRNAs as proto-oncogenes, e.g. GAGE6, as tumor suppressor genes, e.g. 鈥榩15 antisense RNA and lincP21' (36,91), as drivers of metastatic transformation, e.g. HOTAIR in breast cancer, and as regulators of alternative splicing, e.g. MALAT1 22492512 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression The wellstudied lincRNA, HOTAIR, is highly expressed in breast cancer metastases, and its overexpression in various breast carcinoma cell lines promotes invasion 22535282 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes 22817756 LncRNADisease
EL0578 HOTAIR colorectal cancer N/A N/A N/A expression Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes 22817756 LncRNADisease
EL0578 HOTAIR hepatocelluar carcinoma N/A N/A N/A expression Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes 22817756 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A regulation Gene silencing by interacting with PRC2 and LSD1/CoREST complexes. 22996375 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A expression HOTAIR overexpression is associated with poor prognosis in breast (Gupta et al. 2010), liver (Z. Yang et al. 2011), colorectal (Kogo et al. 2011), gastrointestinal (Niinuma et al. 2012), and pancreatic (Kim et al. 2012) cancers and is proposed to increase tumor invasiveness and metastasis (Gupta et al. 2010). 23463798 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A expression HOTAIR overexpression has been linked to increased invasiveness and poorer outcomes in several human cancers. 23473599 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT3: colorectal cancer). 23660942 LncRNADisease
EL0578 HOTAIR hepatocelluar carcinoma N/A N/A N/A expression Dysregulation and functional roles of lncRNAs in HCC 24183851 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A regulation Epigenetically silences gene expression via LSD1/CoREST & PRC2; metastasis 24499465 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression HOTAIR was proposed as a diagnostic marker in breast and colorectal cancer. Its depletion resulted in reduced invasiveness, and its expression level correlated with differentially regulated genes of the PRC2 complex. 24531795 LncRNADisease
EL0578 HOTAIR colorectal cancer N/A N/A N/A expression HOTAIR was proposed as a diagnostic marker in breast and colorectal cancer. Its depletion resulted in reduced invasiveness, and its expression level correlated with differentially regulated genes of the PRC2 complex. 24531795 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR colon cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR colorectal cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR gastrointestinal cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR liver cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR pancreatic cancer N/A N/A N/A expression In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. 24667321 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A expression For example, HOTAIR is remarkably overexpressed in breast tumors and the expression of HOTAIR in primary breast tumors is a strong prognosis marker of patient outcomes such as metastasis and patient survival 24721780 LncRNADisease
EL0578 HOTAIR rheumatoid arthritis N/A N/A N/A regulation PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. 24722995 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A expression Overexpression of HOTAIR was found in breast and colon cancers and was associated with metastasis and poor prognosis. 24757675 LncRNADisease
EL0578 HOTAIR esophageal squamous cell carcinoma N/A N/A N/A expression Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? 24757675 LncRNADisease
EL0578 HOTAIR gastric cancer N/A N/A N/A expression Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? 24757675 LncRNADisease
EL0578 HOTAIR lung cancer N/A N/A N/A expression Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma? 24757675 LncRNADisease
EL0578 HOTAIR esophageal squamous cell carcinoma N/A N/A N/A expression The result showed that the expression levels of HOTAIR were upregulated in samples from patients with higher tumor burdens, which were defined as those with larger tumors, advanced clinical staging, increased lymph node tumor burdens and the presence of distant metastases.? 24817925 LncRNADisease
EL0578 HOTAIR laryngeal squamous cell carcinoma N/A N/A N/A expression Inspired observed that HOTAIR was higher expressed in primary LSCC than in adjacent noncancerous tissues. It is noteworthy that over-expression of HOTAIR was related to poor differentiation, lymph node metastasis, or advanced clinical stages of LSCC. The results suggested that HOTAIR promotes the malignant progression of LSCC. 24817925 LncRNADisease
EL0578 HOTAIR nasopharyngeal carcinoma N/A N/A N/A expression The result showed that, the expression levels of HOTAIR wereup-regulated in NPC tissues than in non-cancerous tissues. Further study demonstrated that HOTAIR was up-regulated in NPC cell lines with high invasive potential and the capacity for migration, invasion and proliferation was suppressed after knocking down HOTAIR expression. 24817925 LncRNADisease
EL0578 HOTAIR oral squamous cell carcinoma N/A N/A N/A expression Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA1 in metastasized samples was prominent higher than the non-metastatic samples.? 24817925 LncRNADisease
EL0578 HOTAIR breast cancer N/A N/A N/A regulation Gupta et al found that lncRNA HOTAIR overexpression was a strong predictor of breast tumor metastasis. 24829860 LncRNADisease
EL0578 HOTAIR cancer N/A N/A N/A regulation Forced expression of HOTAIR in epithelial cancer cells altered the localization of PRC2 on chromatin. Genome-wide studies revealed PRC2 localization more resembling occupancy in embryonic fibroblasts.? 24829860 LncRNADisease
EL0578 HOTAIR lung adenocarcinoma N/A N/A N/A regulation In this study, the lncRNA HOTAIR was upregualted in lung adenocarcinoma cells grown in 3-D cell culture supplemented with collagen.? 24829860 LncRNADisease
EL0578 HOTAIR gastric cardia adenocarcinoma PCR-RFLP, qPCR etc. blood up-regulated mutation Among three htSNPs of the HOTAIR gene (rs12826786 C>T, rs4759314 A>G, and rs10783618 C>T), only the T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage. In addition, higher expression levels of HOTAIR were found in tumor tissues and rs12826786 SNP has a genotype-specific effetc on HOTAIR expression. A high HOTAIR expression level was associated with poor GCA patients' survival. 25476857 Lnc2Cancer
EL0578 HOTAIR breast cancer polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) and created-restriction-site PCR (CRS-RFLP) assays, multifactor dimensionality reduction (MDR) method N/A N/A mutation Subjects with Trs920778 had a significantly increased risk of breast cancer (OR: 1.41, 95%CI: 1.13, 1.75). We observed a significant interaction between rs920778 and reproductive factors, including age at menopause, number of abortions, and family history. Genetic variant rs920778 in HOTAIR significantly increased the risk of BC, and it may have apparent interaction with reproductive factors in the progression on BC. 26547792
EL0578 HOTAIR gastrointestinal stromal tumor qPCR etc. gastric cancer tissue up-regulated expression Overexpression of HOTAIR was also strongly associated with high-risk grade and metastasis among GIST specimens. 22258453 LncRNADisease Lnc2Cancer
EL0578 HOTAIR cervical cancer qPCR etc. cell line (CaSki) down-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL0578 HOTAIR breast cancer qPCR etc. breast cancer tissue differential expression N/A A positive correlation was found between DNA methylation and HOTAIR expression. Methylation was associated with unfavorable disease characteristics, whereas no significant associations were found between HOTAIR expression and clinical or pathologic features. In multivariate, but not in univariate, Cox proportional hazard regression models, patients with high HOTAIR expression had lower risks of relapse and mortality than those with low HOTAIR expression. We found that patients with high levels of HOTAIR expression had lower risks of relapse and death than those with low expression. The results suggest that clinicopathological features and therapy treatments could modify the effect of HOTAIR. Large noncoding RNA HOTAIR, transcribed from the antisense strand of HOXC12, interacts with Polycomb Repressive Complex 2 (PRC2) in the regulation of gene activities. 23124417 Lnc2Cancer
EL0578 HOTAIR oral squamous cell carcinoma qPCR etc. OSCC tissues up-regulated N/A We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. 23292713 Lnc2Cancer
EL0578 HOTAIR hepatocelluar carcinoma qPCR etc. HCC tissue, cell lines (HepG2 cell line) up-regulated expression Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. 23292722 LncRNADisease Lnc2Cancer
EL0578 HOTAIR ovarian cancer qPCR etc. ovarian cancer tissue up-regulated N/A The expression of HOTAIR in ovarian cancer tissue was higher than that in normal ovarian tissue. The expression was statistically higher in poorly differentiated ovarian cancer than poorly-moderately, moderately-well, and well-differentiated ones (1.65 +/- 0.41 vs. 0.39 +/- 0.14, P < 0.05). 23600210 Lnc2Cancer
EL0578 HOTAIR lung cancer qPCR etc. lung cancer tissue cell lines (A549, mK-ras-LE etc.) up-regulated N/A In the current study, we demonstrate that the tumor-promoting lincRNA HOTAIR is induced by Col-1 and its expression inversely correlates with acinar morphogenesis, a differentiation feature of lung epithelial cells in rBM 3-D culture. These in vitro findings suggest that the elevated HOTAIR expression in tumor tissues results from cancer cells' response to Col-1 that is aberrantly enriched in the tumor microenvironment. Our findings indicate that tumor-promoting Col-1 up-regulates the expression of HOTAIR in NSCLC cells. These initial results warrant further investigation of HOTAIR and other lincRNA genes in lung tumorigenesis. 23668363 Lnc2Cancer
EL0578 HOTAIR non-small cell lung cancer qPCR etc. NSCLC tissue, cell lines (A549) up-regulated N/A High expression of HOTAIR (tumor/normal ratio >= 2) was detected in 17 patients (22.1%) and was frequently found in patients with advanced stage, lymph node metastasis or lymph-vascular invasion and short disease free interval. Furthermore, brain metastases show significantly higher HOTAIR expression compared to primary cancer tissues. HOTAIR-expressing A549 cells showed induced cell migration and anchorage independent cell growth in vitro. 23743197 Lnc2Cancer
EL0578 HOTAIR gastric adenocarcinoma qPCR etc. gastric adenocarcinoma tissue up-regulated N/A Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long noncoding RNA in gastric cancer progression. 23888369 Lnc2Cancer
EL0578 HOTAIR endometrial cancer qPCR etc. endometrial carcinoma tissue up-regulated expression The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. 24285342 LncRNADisease Lnc2Cancer
EL0578 HOTAIR pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated expression Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. 24469926 LncRNADisease Lnc2Cancer
EL0578 HOTAIR multiple myeloma qPCR etc. blood (plasma) down-regulated expression HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. 24583225 LncRNADisease Lnc2Cancer
EL0578 HOTAIR colorectal cancer qPCR etc. colorectal cancer tissue, blood up-regulated regulation HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. 24583926 LncRNADisease Lnc2Cancer
EL0578 HOTAIR cervical cancer qPCR etc. cervical cancer tissue up-regulated expression Overexpression of?long?noncoding?RNA?HOTAIR predicts a poor prognosis in patients with cervical cancer. 24748337 LncRNADisease Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR etc. gastric cancer tissue up-regulated N/A The expression of HOTAIR was markedly increased in gastric cancer tissues compared with adjacent non-tumoral tissues. We further showed that there was a positive significant correlation between the HOTAIR gene expression, TNM staging, perineural invasion, and distant metastasis, but not with other clinicopathological features of gastric tumors. HOTAIRexpression is modulated during gastric cancer progression and therefore may participate in molecular processes relevant to malignant transformation and metastasis in gastric carcinoma. 24949306 Lnc2Cancer
EL0578 HOTAIR laryngeal squamous cell carcinoma qPCR etc. LSCC tissue up-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
EL0578 HOTAIR breast cancer qPCR etc. cells lines (MCF-7) up-regulated interaction When compared with MCF-7 cells, MCF-7-TNR cells exhibited an increase in the expression of HOTAIR, which correlated with characteristics of a luminal-like to basal-like transition as evidenced by dysregulated gene expression and accelerated growth. MCF-7-TNR cells exhibited reduced suppressive histone H3 lysine27 trimethylation on the HOTAIR promoter. Inhibition of HOTAIR and EZH2 attenuated the luminal-like to basal-like transition in terms of gene expression and growth in MCF-7-TNR cells. HOTAIR was robustly expressed in the native basal-like breast cancer cells and inhibition of HOTAIR reduced the basal-like gene expression and growth. 25328122 Lnc2Cancer
EL0578 HOTAIR cervical cancer qPCR etc. blood (serum) up-regulated expression Compared with normal control, the expression of HOTAIR was significantly upregulated in the sera of cervical cancer patients. In addition, elevated HOTAIR was associated with advanced tumor stages, adenocarcinoma, lymphatic vascular space invasion, and lymphatic node metastasis. In addition, our follow-up data showed that high HOTAIR was notably correlated with tumor recurrence and short overall survival. 25366139 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. 26096073 Lnc2Cancer
EL0578 HOTAIR gastric adenocarcinoma qPCR etc. gastric cancer tissue up-regulated expression HOTAIR was significantly upregulated in GA tissues, especially in more advanced cases. High HOTAIR expression was an independent poor prognostic factor for patients with advanced GA. Further stratification analyses revealed that the association between HOTAIR expression and survival in patients with advanced GA remained significant in the subgroup of patients with TNM stages IIIA and IIIB, poorly differentiated, and smaller tumors. 26328013 Lnc2Cancer
EL0578 HOTAIR ovarian cancer qPCR etc. ovarian cancer tissue up-regulated expression HOTAIR expression was significantly associated with poor survival in carboplatin-treated patients with adjusted hazard ratios for death of 3.64 in the discovery and 1.63 in the validation set. This effect was not seen in patients who did not receive carboplatin. HOTAIR expression or its surrogate DNAme signature predicted poor outcome in all additional sets of carboplatin-treated ovarian cancer patients while HOTAIR expressors responded preferentially to cisplatin. 26497652 Lnc2Cancer
EL0578 HOTAIR breast cancer qPCR, ChIP-chip etc. cell lines (SUZ12, EZH2, PRC2 etc.) up-regulated expression HOTAIR expression level in primary tumors is a powerful predictor of eventual metastasis and death. 20393566 LncRNADisease Lnc2Cancer
EL0578 HOTAIR laryngeal squamous cell carcinoma qPCR, in vitro knockdown etc. cell lines (Hep-2) up-regulated N/A HOTAIR levels were significantly higher in LSCC than in corresponding adjacent non-neoplastic tissues, and patients with poor histological grade or advanced clinical stage had higher HOTAIR expression. PTEN methylation was significantly reduced in Hep-2 cells depleted of HOTAIR. Taken together, these results suggest that the oncogenic role of HOTAIR in LSCC is related to promotion of PTEN methylation. 23141928 Lnc2Cancer
EL0578 HOTAIR melanoma qPCR, in vitro knockdown etc. melanoma tissue, cell lines (A375 etc.) up-regulated N/A Among the tested lncRNAs, HOTAIR was the most highly expressed in lymph node metastasis. The role of HOTAIR in melanoma cell motility and invasion was further evaluated by knocking down HOTAIR with siRNAs. Knockdown of HOTAIR resulted in the reduction of motility and invasion of human melanoma cell line A375, as assessed by wound healing assay and Matrigel-based invasion assay. siHOTAIR also suppressed the degradation of gelatin matrix, suggesting that HOTAIR promotes gelatinase activity. Together, our study shows thatHOTAIR is overexpressed in metastatic tissue, which is associated with the ability of HOTAIR to promote melanoma cell motility and invasion. 23862139 Lnc2Cancer
EL0578 HOTAIR esophageal squamous cell carcinoma qPCR, in vitro knockdown etc. ESCC tissu, cell lines (TE1, TE3, TE7, TE8, KYSE30, KYSE180 etc.) up-regulated regulation Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. 24022190 LncRNADisease Lnc2Cancer
EL0578 HOTAIR nasopharyngeal carcinoma qPCR, ISH etc. primary NPC tissue up-regulated N/A Quantified using qPCR, HOTAIR expression levels in fresh tissue and paraffin-embedded samples were 5.2 ~ 48.4-fold higher compared with non-cancer tissue samples. Moreover, HOTAIR expression levels increased with clinical stage progression, which was consistent with ISH findings in the paraffin-embedded tissue. Most importantly, NPC patients with higher HOTAIR levels had a poor prognosis for overall survival using univariate and multivariate analysis. In addition, HOTAIR mediated the migration, invasion and proliferation of NPC cells in vitro. 23281836 Lnc2Cancer
EL0578 HOTAIR esophageal squamous cell carcinoma qPCR, ISH etc. ESCC tissue up-regulated N/A High expression levels of HOTAIR in ESCC patients correlated positively with clinical stage, TNM classification, histological differentiation and vital status. HOTAIR expression was found to be an independent prognostic factor in ESCC patients. ESCC patients who expressed high levels of HOTAIR had substantially lower overall 5-year survival rates than HOTAIR-negative patients. In vitro assays of ESCC cell lines demonstrated that HOTAIR mediated the proliferation, colony formation and migratory capacity of ESCC cells. 23717443 Lnc2Cancer
EL0578 HOTAIR breast cancer qPCR, ISH, RIP, ChIP etc. breast cancer tissue, cell lines (MCF7, T47D) up-regulated interaction In this study, we report that HOTAIR (HOX antisense intergenic RNA) is upregulated in tamoxifen-resistant breast cancer tissues compared to their primary counterparts. Mechanistically, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the blockade of ER signaling, either by hormone deprivation or by tamoxifen treatment. Interestingly, this elevated HOTAIR increases ER protein level and thus enhances ER occupancy on the chromatin and potentiates its downstream gene regulation. 26364613 Lnc2Cancer
EL0578 HOTAIR hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (SMMC-7721, HepG2, Hep3B etc.) up-regulated expression Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. 21327457 LncRNADisease Lnc2Cancer
EL0578 HOTAIR colorectal cancer qPCR, knockdown etc. CRC tissue, (HEK293T, HCT116, SW480) up-regulated epigenetics Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.patients with high HOTAIR expression had a relatively poorer prognosis. 21862635 LncRNADisease Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines(MKN74, KATO III etc.) up-regulated N/A The expression of HOTAIR was significantly higher in cancer lesions than in adjacent non-cancerous tissues in human gastric cancers. In the diffuse type of gastric cancer, the High-HOTAIR group (HOTAIR/GAPDH > 1) showed significantly more venous invasion, frequent lymph node metastases and a lower overall survival rate compared to the Low-HOTAIR group (HOTAIR/GAPDH < 1). 24130837 Lnc2Cancer
EL0578 HOTAIR esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (KYSE30, KYSE150, KYSE450, KYSE510, KYSE180 etc.) up-regulated N/A Notably elevated HOTAIR expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues (96%, P < 0.01), showing a high correlation with cancer metastasis (P < 0.01), elevated TNM (2009) stage classification (P < 0.01), and lowered overall survival rates (P = 0.003). Multivariate analysis revealed that HOTAIR expression (P = 0.003) is also an independent prognostic factor for comparison of TNM stage (P = 0.024) and lymph node metastasis (P = 0.010). 24151120 Lnc2Cancer
EL0578 HOTAIR small cell lung cancer qPCR, knockdown etc. cell lines (COLO-668, COR-L51, COR-L88, DMS-79, DMS-53 etc.) up-regulated regulation Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. 24591352 LncRNADisease Lnc2Cancer
EL0578 HOTAIR endometrial cancer qPCR, knockdown etc. endometrioid carcinoma tissues, cell lines (HEC-1A, HEC-1B, Ishikawa, RL-952) up-regulated regulation Lentivirus-Mediated?RNA?Interference Targeting the?Long?Noncoding?RNA?HOTAIR Inhibits Proliferation and Invasion of Endometrial Carcinoma Cells In Vitro and In Vivo. 24758900 LncRNADisease Lnc2Cancer
EL0578 HOTAIR lung cancer qPCR, knockdown etc. lung cancer tissue up-regulated N/A Among the tested lncRNAs, HOTAIR and NEAT1 were most highly expressed in lymph node metastasis. However, only HOTAIR was subsequently found to be involved in lung cancer cell motility and invasion, as assessed by in vitro migration and invasion assay. 25010625 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (MKN7, MKN45, MKN74, NUGC4, AZ521, AGS, KATOIII) up-regulated interaction Expression of both lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients. In addition, elevated HOTAIR expression emerged both as an independent prognostic and risk factor for peritoneal dissemination. SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation, migration and invasion, but concurrently enhanced the anoikis rate in transfetced cells. 25280565 Lnc2Cancer
EL0578 HOTAIR colorectal cancer qPCR, knockdown etc. CRC tissue up-regulated expression Our study showed that genetic variants in HOTAIR were associated with risk of colorectal cancer and rs7958904 may act as a potential biomarker for predicting the risk of colorectal cancer. 25432874 Lnc2Cancer
EL0578 HOTAIR serous ovarian cancer qPCR, knockdown etc. cell lines (A2780, Hey, SKOV3, OVCA429, OVCA433, OVCAR3) up-regulated expression We found that HOTAIR levels were overexpressed in SOC tissues compared with normal controls and that HOTAIR overexpression was correlated with an advanced FIGO stage and a high histological grade. HOTAIR knockdown resulted in the induction of cell cycle arrest and apoptosis through certain cell cycle-related and apoptosis-related proteins. 25796453 Lnc2Cancer
EL0578 HOTAIR acute myeloid leukemia qPCR, knockdown etc. bone marrow, cell lines (HL60, K562) up-regulated expression We found that HOTAIR is significantly upregulated in de novo AML patients compared with those of AML-CR patients and normal controls; the reduction of HOTAIR by small interfering RNA (siRNA) repressed the proliferation of HL-60 and K562; the higher expression level of HOTAIR in AML patients was significantly correlated with NCCN high risk group. 26261618 Lnc2Cancer
EL0578 HOTAIR lung adenocarcinoma qPCR, knockdown etc. NSCLC and adjacent non-tumor lung tissues, cell lines (A549, PC9, H1299, H520, HBE) up-regulated interaction HOTAIR regulates the ratio of FOXA1 to FOXA2 and migration and invasion. HOTAIR and the ratio of FOXA1 to FOXA2 are negatively correlated. HOTAIR knockdown inhibits migration and invasion. HOTAIR is associated with LSH, and this association linked with the binding of LSH in the promoter of FOXA1, not FOXA2. Targeted inhibition of HOTAIR suppresses the migratory and invasive properties 26658322 Lnc2Cancer
EL0578 HOTAIR pancreatic cancer qPCR, Luciferase reporter assay, in vitro knockdown etc. cell lines (Panc1, MiaPaCa2, Panc28, L3.6pl) up-regulated N/A We show that HOTAIR expression is increased in pancreatic tumors compared with non-tumor tissue and is associated with more aggressive tumors. Knockdown of HOTAIR (siHOTAIR) by RNA interference shows that HOTAIR has an important role in pancreatic cancer cell invasion, as reported in other cancer cell lines. HOTAIR knockdown in Panc1 and L3.6pL pancreatic cancer cells that overexpress this lincRNA decreased cell proliferation, altered cell cycle progression and induced apoptosis, demonstrating an expanded function of HOTAIR in pancreatic cancer cells compared with other cancer cell lines. HOTAIR uniquely suppressed several interferon-related genes and gene sets related to cell cycle progression in pancreatic cancer cells and tumors. 22614017 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, Luciferase reporter assay, knockdown, ELISA etc. gastric cancer tissue, cell lines (SGC7901, MGC-803) up-regulated interaction Significant HOTAIR overexpression was observed in GC tissues, as well as strong positive correlations with HLA-G levels in both tissue and peripheral blood samples. HOTAIR overexpression might also get involved in tumor escape mechanisms, involving HLA-G upregulation via inhibiting miR-152. 26187665 Lnc2Cancer
EL0578 HOTAIR gallbladder cancer qPCR, Northern blot, in vitro knockdown, RIP etc. gallbladder cancer tissue, cell lines (GBC-SD, SGC-996,NOZ, EH-GB2 etc.) up-regulated N/A The HOTAIR transcripts were expressed at higher levels in the tumor tissues compared with adjacent normal tissues (p < 0.0001), indicating that HOTAIR was frequently up-regulated in GBC.A positive correlation between c-Myc and HOTAIR mRNA levels was observed in gallbladder cancer tissues. HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. 24953832 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, Northern blot, knockdown etc. gastric cancer tissue up-regulated N/A HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1. Our findings provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation and the ensuing malignant phenotype in both cultured and xenograft gastric cancer cells. 25612617 LncRNADisease Lnc2Cancer
EL0578 HOTAIR prostate cancer qPCR, RNA Pull-Down Assay, RIP, ChIP etc. prostate cancer tissue up-regulated interaction Here, we report HOTAIR as an androgen-repressed lncRNA, and, as such, it is markedly upregulated following androgen deprivation therapies and in CRPC. Functionally, HOTAIR overexpression increases, whereas HOTAIR knockdown decreases, prostate cancer cell growth and invasion. Taken together, our results provide compelling evidence of lncRNAs as drivers of androgen-independent AR activity and CRPC progression, and they support the potential of lncRNAs as therapeutic targets. 26411689 Lnc2Cancer
EL0578 HOTAIR aortic valve calcification qPCR, siRNA, DNA microarray BAVs, human aortic interstitial cells (AVICs) down-regulated expression Reducing HOTAIR levels via siRNA in AVICs results in increased expression of calcification genes. 24788418
EL0578 HOTAIR sarcoma qPCR, Western blot etc. Primary and metastatic sarcoma tumor tissue up-regulated N/A High level expression of both of MTDH/AEG1 and HOTAIR in the primary tumor correlated with a likelihood to metastasize. High levels of both MTDH/AEG-1 and HOTAIR in primary sarcoma are correlated with a high probability of metastasis. By contrast, reduced expression of both MTDH/ AEG-1 and HOTAIR is correlated with a good response to treatment in terms of necrosis, suggesting that levels of MTDH and HOTAIR are potential biomarkers for treatment efficacy. 23543869 Lnc2Cancer
EL0578 HOTAIR bladder cancer qPCR, Western blot etc. bladder cancer tissue, cell lines (T24, J82, BIU-87 etc.) up-regulated expression Ninety out of 110 specimens were detected in HOTAIR high expression. Histological grade and expression levels of HOTAIR were positively correlated with the recurrence rate. HOTAIR expression (hazard ratio 4.712; 95 % CI 2.894-8.714; P < 0.001) was an independent predictor of recurrence rate in multivariate Cox regression analysis. HOTAIR expression is correlated with patients' poor prognosis. 25030736 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, Western blot etc. gastric cancer tissue, gastric cell lines up-regulated interaction The expression of HOTAIR was significantly elevated in various gastric cancer cell lines and tissues compared to normal control. Lymphovascular invasion and lymph node metastasis were more common in the high level of HOTAIR group. si-HOTAIR significantly decreased invasiveness and migration. si-HOTAIR led to differential expression of epithelial to mesenchymal transition markers. HOTAIR was involved in inhibition of apoptosis and promoted invasiveness, supporting a role for HOTAIR in carcinogenesis and progression of gastric cancer. 25063030 Lnc2Cancer
EL0578 HOTAIR laryngeal squamous cell carcinoma qPCR, Western blot etc. blood (serum) up-regulated N/A The expression of exosomal miR-21 and HOTAIR was significantly higher in patients with laryngeal squamous cell carcinomaLSCC than those with vocal cord polyps; The patients with lymph node metastasis had higher serum exosomal miR-21 and HOTAIR expressions than those without. 25099764 LncRNADisease Lnc2Cancer
EL0578 HOTAIR cervical cancer qPCR, Western blot etc. cervical cancer tissue, cell lines (HeLa, SiHa, C33A, CaSki) differential expression regulation Stable knockdown of HOTAIR significantly suppressed tumor growth and sensitized cervical cancer to radiotherapy in vivo. 25547435 Lnc2Cancer
EL0578 HOTAIR hepatocelluar carcinoma qPCR, Western blot etc. cell lines (HepG2, Bel7404, PLC5, Huh7 etc.) up-regulated interaction We found that Hotair was increased in HCC tissues compared to their adjacent non-tumor tissues and the normal liver tissues. Increased Hotair negatively regulated miR-218 expression in HCC, which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis. Further investigation revealed that Hotair knockdown dramatically inhibited cell viability and induced G1-phase arrest in vitro and suppressed tumorigenicity in vivo by promoting miR-218 expression. 26024833 Lnc2Cancer
EL0578 HOTAIR bladder cancer qPCR, Western blot etc. bladder cancer tissue up-regulated interaction Our findings indicate that HOTAIR expression has prognostic value for bladder cancer progression, recurrence, and survival and suggest that HOTAIR plays active roles in modulating the cancer epigenome, becoming an interesting candidate as a target for cancer diagnosis and therapy. The observed HOTAIR regulation by EZH2 and the possibility of modulating EZH2 activity with specific inhibitors open new possible paths to be explored in bladder cancer therapy 26457124 Lnc2Cancer
EL0578 HOTAIR head and neck squamous cell carcinoma qPCR, Western blot, Flow cytometry assay etc. cell lines (Tca8113, Tca8113P160, Tb3.1) differential expression interaction We employed a HOTAIR specific siRNA to deplete its expression in two human HNSCC cell lines, Tca8113 and Tscca. The flow cytometry (FCM) analysis showed that HOTAIR depletion induced tumor cell apoptosis in vitro. JC-1 probe examination showed that the mitochondrial membrane potential was changed significantly by HOTAIR blockage. Mitochondrial calcium uptake 1(MICU1) dependent cell death was induced by HOTAIR depletion. Protein expression analysis indicated that mitochondrial related cell death pathway (Bcl-2, BAX, Caspase-3, Cleaved Caspase-3, Cytochrome c) involved in HOTAIR dependent apoptosis process. Moreover, a Tscca derived xenograft tumor model was employed to further validate that injection of HOTAIR siRNA inhibited tumor growth. In summary, we suggested that HOTAIR inhibition could be developed as a new therapeutic in HNSCC treatments. 26592246 Lnc2Cancer
EL0578 HOTAIR hepatocelluar carcinoma qPCR, Western blot, in vitro knockdown etc. cell line (Bel7402) up-regulated expression The HOTAIR gene was significantly overexpressed in HCC tissues compared with adjacent non-tumour tissues. Patients with high HOTAIR gene expression in their tumours had an increased risk of recurrence after hepatectomy. 22289527 LncRNADisease Lnc2Cancer
EL0578 HOTAIR non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1,NCI-H1975 etc.) up-regulated N/A HOTAIR was highly expressed both in NSCLC samples and cell lines compared with corresponding normal counterparts. HOTAIR upregulation was correlated with NSCLC advanced pathological stage and lymph-node metastasis. Moreover, patients with high levels of HOTAIR expression had a relatively poor prognosis. 24103700 Lnc2Cancer
EL0578 HOTAIR lung adenocarcinoma qPCR, Western blot, knockdown etc. lung adenocarcinoma tissue, cell lines (A549/DDP, SPC-A1 etc.) up-regulated N/A In this study, we show that HOTAIR expression was significantly upregulated in cisplatin-resistant A549/DDP cells compared with in parental A549 cells. Knockdown of HOTAIR by RNA interference could resensitize the responses of A549/DDP cells to cisplatin both in vitro and in vivo. In contrast, overexpression of HOTAIR could decrease the sensitivity of A549 and SPC-A1 cells to cisplatin. 24155936 Lnc2Cancer
EL0578 HOTAIR ovarian cancer qPCR, Western blot, knockdown etc. epithelial ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) up-regulated expression Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer. 24662839 LncRNADisease Lnc2Cancer
EL0578 HOTAIR colon cancer qPCR, Western blot, knockdown etc. colon cancer tissue, cell lines (SW480, HT29) up-regulated expression Long?non-coding?RNA?HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. 24840737 LncRNADisease Lnc2Cancer
EL0578 HOTAIR cervical cancer qPCR, Western blot, knockdown etc. cervical cancer tissue, cell lines (SiHa, HeLa, Caski) up-regulated expression The expression level of HOTAIR in cervical cancer tissues was higher than that in corresponding non-cancerous tissues. High HOTAIR expression correlated with lymph node metastasis, and reduced overall survival. Moreover, HOTAIR regulated the expression of vascular endothelial growth factor, matrix metalloproteinase-9 and epithelial-to-mesenchymal transition (EMT)-related genes, which are important for cell motility and metastasis. 25405331 Lnc2Cancer
EL0578 HOTAIR ovarian cancer qPCR, Western blot, knockdown etc. cell lines (SKOV3) up-regulated interaction The results demonstrated that the HOTAIR expression in clinical EOC tissues and SKOV3 CD117(+)CD44(+)CSCs was higher than in SKOV3 tumor tissues and non-CD117(+)CD44(+)CSCs. 25792974 Lnc2Cancer
EL0578 HOTAIR oral squamous cell carcinoma qPCR, Western blot, knockdown etc. OSCC tissue, cell lines (TSCCA, Tca8223 etc.) up-regulated N/A Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. 25901533 LncRNADisease Lnc2Cancer
EL0578 HOTAIR colorectal cancer qPCR, Western blot, knockdown etc. CRC tissue, cell lines (FHC, CCL244, HCT116, SW480, LOVO) up-regulated expression Results showed that CRC patients had higher HOTAIR expression in tumor tissues compared with adjacent normal tissues. In vitro, downregulation of HOTAIR reduced proliferation, migration and invasiveness while enhanced apoptosis and radio-sensitivity of CRC cells. Taken together, our findings suggest that long non-coding RNA HOTAIR expression is closely associated with tumor invasion and radiosensitivity, indicating the potential role in diagnostics and therapeutics of CRC. 26549670 Lnc2Cancer
EL0578 HOTAIR renal cell carcinoma qPCR, Western blot, knockdown, ChIP etc. cell lines (A-498, OS-RC-2) up-regulated N/A Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells. 25149152 LncRNADisease Lnc2Cancer
EL0578 HOTAIR ovarian cancer qPCR, Western blot, knockdown, MTT assay etc. ovarian cancer tissue, cell lines (A2780, 3AO, OVCAR3, SKOV3, HO-8910) up-regulated interaction HOTAIR overexpression promoted cell cycle progression (and thus cell proliferation) by activating the Wnt/β-Catenin signaling pathway. Likewise, knockdown of HOTAIR suppressed cell proliferation and arrested cell cycle at G1 phase via inhibition of Wnt/β-Catenin signaling. Moreover, the results of primary culture demonstrated that elevated HOTAIR expression correlated positively with chemoresistance in ovarian cancer. 26341496 Lnc2Cancer
EL0578 HOTAIR acute myeloid leukemia qPCR, Western blot, knockdown, RIP etc. cell lines up-regulated interaction We report that HOTAIR expression was obviously increased in leukemic cell lines and primary AML blasts. Clinically, AML patients with higher HOTAIR predicted worse clinical outcome compared with those with lower HOTAIR. Importantly, HOTAIR knockdown by small hairpin RNA inhibited cell growth, induced apoptosis, and decreased number of colony formation. Finally, HOTAIR modulated c-KIT expression by competitively binding miR-193a. 25979172 Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, Western blot, Luciferase reporter assay, knockdown etc. gastric cancer tissue, cell lines (MGC-803, SGC-7901, BGC-823, AGS) up-regulated regulation Lnc RNA HOTAIR functions as a competing endogenous?RNA?to regulate HER2 expression by sponging miR-331-3p in gastric cancer. 24775712 LncRNADisease Lnc2Cancer
EL0578 HOTAIR non-small cell lung cancer qPCR, Western blot, Luciferase reporter assay, knockdown etc. cell lines (A549, SK-MES-1) up-regulated interaction In the present study, we demonstrated that HOTAIR was upregulated by hypoxia in NSCLC cells. HOTAIR is a direct target of HIF-1αthrough interaction with putative HREs in the upstream region of HOTAIR in NSCLC cells. Furthermore, HIF-1α knockdown or inhibition could prevent HOTAIR upregulation under hypoxic conditions. Under hypoxic conditions, HOTAIR enhanced cancer cell proliferation, migration, and invasion. 26088446 Lnc2Cancer
EL0578 HOTAIR liver cancer qPCR, Western blot, Luciferase reporter assay, RIP etc. liver cancer tissue, cell line (hLCSC) up-regulated interaction HOTAIR level was significantly higher in human hepatocarocinoma tissues and play tumorigenesis roles by downregulating SETD2 in liver cancer stem cells. HOTAIR may also mediate changes at an epigenetic level to affect gene expression and contribute to tumor aetiology. 26172293 Lnc2Cancer
EL0578 HOTAIR bladder cancer qPCR, Western blot, Northern blot etc. cell lines(HCV29, 5637, T24, J82, SW780 ) up-regulated interaction We have identified cyclin J (CCNJ) gene, which is involved in cell cycle regulation, as a novel target for miR-205. Furthermore, a long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter. 26469956 Lnc2Cancer
EL0578 HOTAIR renal cancer qPCR, Western blot, RIP etc. cell lines (86-O, ACHN) up-regulated expression Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells. 24616104 LncRNADisease Lnc2Cancer
EL0578 HOTAIR gastric cancer qPCR, Western bolt, in vitro knockdown etc. gastric cancer tissue, cell lines (GES-1, AGS, SGC-7901, MKN-45, HGC-27 etc.) up-regulated N/A The expression level of HOTAIR in cancer tissues was higher than that in adjacent noncancerous tissues. Expression level of HOTAIR was significantly correlated with lymph node metastasis and TNM stage. Furthermore, high expression level of HOTAIR was a predictor of poor over-all survival in GC patients. In vitro, inhibition of HOTAIR in GC cells could reduce invasiveness, as well as the expression of MMP1 and MMP3. In addition, suppression of HOTAIR could reverse EMT process. 23847441 Lnc2Cancer
EL0578 HOTAIR glioma qRT-PCR, knock-down glioma U87 and U251 cell lines up-regulated expression knock-down of HOTAIR exerted tumor-suppressive function in glioma cells. Further, HOTAIR was confirmed to be the target of miR-326 and miR-326 mediated the tumor-suppressive effects of HOTAIR knock-down on glioma cell lines 26183397
EL0578 HOTAIR pre-eclampsia qRT-PCR, knockdown, overexpression placentas from pre-eclampsia (PE) pregnant women up-regulated expression HOTAIR is probably involved in the onset of preeclampsia by regulating proliferation, invasion and apoptosis of trophoblast cells. 25807808
EL0578 HOTAIR bladder transitional cell carcinoma quantitative real-time PCR, MTT assay, Dual-color flow cytometric method bladder transitional cell carcinoma (TCC) tissues and cell lines up-regulated expression HOTAIR over-expression promoted cell proliferation and inhibited chemosensitivity to doxorubicin and cell apoptosis induced by doxorubicin; silence of HOTAIR showed opposite regulative effects. lncRNA HOTAIR was an independent prognostic biomarker of overall survival in TCC patients and could regulate chemosensitivity to doxorubicin of human TCC cells. 26781446
EL0578 HOTAIR breast cancer real-time polymerase chain reaction (PCR) using TaqMan assay 123 BC patients and 122 age-matched healthy controls N/A mutation TT genotype of HOTAIR rs12826786 C>T polymorphism was significantly related with multiple clinicopathological characteristics concerned with worse BC progression such as advanced TNM stage (III and IV), larger tumor size (T3 and T4), and distant metastasis (M1), as well as poor histological grade (III) (P < 0.05). 26577852
EL0578 HOTAIR breast cancer RNA CISH etc. breast cancer tissue up-regulated expression HOTAIR, H19 and KCNQ1OT1 had significantly higher expression levels in IBC than NA, and HOTAIR and H19 were both expressed more strongly in IBC than in DCIS tissues. 26323944 Lnc2Cancer
EL0578 HOTAIR infiltrating ductal carcinomas RNA-seq, qRT-PCR human mammary epithelial cells (non-transformed) and the breast cancer cell line MCF-7 up-regulated expression The lncRNA HOTAIR was significantly overexpressed in the HER2-enriched subgroup. 25296969
EL0578 HOTAIR endometrial cancer RT-qPCR 156 consecutive, stage I-IV EC patients N/A N/A high HOTAIR expression correlated with shorter overall survival 26868332
EL0578 HOTAIR breast cancer TaqMan allelic discrimination assay etc. blood differential expression expression We found that the CC genotype of HOTAIR rs920778 polymorphism significantly increased the risk of BC in both codominant and recessive inheritance genetic models. Our research also indicated an association between the CC genotype of HOTAIR rs920778 polymorphism and clinicopathologic features of tumor, including advanced tumor-node-metastasis (TNM) stage, larger tumor size, distant metastasis, and poor histological grade. CC genotype of HOTAIR rs920778 polymorphism might play important roles in genetic susceptibility to BC development and aggressiveness in a Turkish population. 25586347 Lnc2Cancer
EL0578 HOTAIR gastric cancer TaqMan RT-PCR gastric cancer samples N/A mutation A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. 25980897
EL0578 HOTAIR diffuse large B-cell lymphoma The reverse transcription‑polymerase chain reaction & Western blotting N/A up-regulated N/A HOTAIR was significantly correlated with tumor size, clinical stage, B symptoms and International Prognostic Index scores 27122348
EL0578 HOTAIR colorectal cancer the tumorigenicity of CD133(+)-shHOTAIR were evaluated by the MTT CD133(+)CSCs cell down-regulated N/A down-regulating the HOTAIR expression in CD133(+)CSCs could serve as a potential anti-cancer regimen to inhibit the invasiveness and metastasis of CRC CSCs 27069543
EL0579 Hotair homeotic transformation of the spine and malformation of metacarpal-carpal bone knockdown, RNA-sequencing N/A N/A interaction Targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones. 24075995
EL0580 HOTAIRM1 acute myeloid leukemia N/A 241 AML patients, 215 intermediate-risk AML (IR-AML) patients N/A interaction In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004). 26433964
EL0580 HOTAIRM1 pancreatic ductal adenocarcinoma N/A pancreatic ductal adenocarcinoma (PDAC) tissues up-regulated expression The expression level of long intergenic non-coding RNA HOTAIRM1 was upregulated in 12 PDAC tissues samples compared with matched adjacent non-tumor samples by qRT-PCR. The revelation of an association between HOTAIRM1 expression and PDAC is especially noteworthy. 26676849
EL0580 HOTAIRM1 acute promyelocytic leukemia qPCR, knockdown etc. cell lines (NB4, HEK293) up-regulated N/A HOTAIRM1 is Highly expressed and provides a regulatory link in myeloid maturation by modulating integrin-controlled cell cycle progression at the gene expression level. 24824789 Lnc2Cancer
EL0580 HOTAIRM1 promyelocytic leukemia qPCR, knockdown etc. cell lines (NB4 and HEK293) down-regulated N/A HOTAIRM1 knockdown resulted in retained expression of many otherwise ATRA-suppressed cell cycle and DNA replication genes, and abated ATRA induction of cell surface leukocyte activation, defense response, and other maturation-related genes. Resistance to ATRA-induced cell cycle arrest at the G1/S phase transition in knockdown cells was accompanied by retained expression of ITGA4 (CD49d) and decreased induction of ITGAX (CD11c). The coupling of cell cycle progression with temporal dynamics in the expression patterns of these integrin genes suggests a regulated switch to control the transit from the proliferative phase to granulocytic maturation. Furthermore, ITGAX was among a small number of genes showing perturbation in transcript levels upon HOTAIRM1 knockdown even without ATRA treatment, suggesting a direct pathway of regulation 24824789 Lnc2Cancer
EL0580 HOTAIRM1 infiltrating ductal carcinomas RNA-seq, qRT-PCR human mammary epithelial cells (non-transformed) and the breast cancer cell line MCF-7 up-regulated expression The lncRNA HOTAIRM1 was significantly overexpressed in the basal-like subgroup. 25296969
EL0582 HOTTIP hepatocelluar carcinoma dual luciferase reporter gene assays HCC tissue specimens, mouse xenograft model up-regulated interaction Tthe miR-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis. 26710269
EL0582 HOTTIP pancreatic cancer microarray, qPCR, Western blot, knockdown etc. cell lines (Panc1, ASPC1, BxPC3 etc.) up-regulated interaction HOTTIP is expressed in pancreatic cancer cell lines and knockdown of HOTTIP by RNA interference (siHOTTIP) in Panc1 pancreatic cancer cells decreased proliferation, induced apoptosis and decreased migration. HOTTIP functions in pancreatic cancer cells are due, in part, to regulation of some HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1. 25912306 Lnc2Cancer
EL0582 HOTTIP pancreatic ductal adenocarcinoma microarray, qRT-PCR eight human pancreatic ductal adenocarcinoma (PDAC) tissues and four pancreatic tissues. up-regulated expression Functionally, HOTTIP silencing resulted in proliferation arrest by altering cell-cycle progression, and impaired cell invasion by inhibiting epithelial-mesenchymal transition in pancreatic cancer. HOTTIP promotes cell proliferation, invasion, and chemoresistance by modulating HOXA13. Therefore, the HOTTIP/HOXA13 axis is a potential therapeutic target and molecular biomarker for PDAC. 25889214
EL0582 HOTTIP prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0582 HOTTIP lung cancer N/A lung cancer cell line A549 and NCI-H446; tissue of lung cancer up-regulated expression Initially, we found that expression of HOTTIP was significantly elevated in 20 cases of lung cancer.Tumor growth in vivo was also suppressed after depletion of HOTTIP in a mouse model of lung cancer. Moreover, depletion of HOTTIP caused cell cycle arrest in G0/G1 phase and induced significant cell apoptosis. 26265284
EL0582 HOTTIP hepatocelluar carcinoma N/A N/A N/A expression Currently, upregulated HOTTIP and HOXA13 expressions were associated with the prognosis and progression of the hepatocellular carcinoma (HCC). 24531795 LncRNADisease
EL0582 HOTTIP tongue squamous cell carcinoma qPCR etc. tongue cancer tissue up-regulated expression In our study, results indicated that lncRNA HOTTIP was highly expressed in TSCC compared with adjacent non-malignant tissues and positively correlated with T stage, clinical stage, and distant metastasis in TSCC patients. 26058875 Lnc2Cancer
EL0582 HOTTIP colorectal cancer qPCR etc. colorectal cancer samples and 21 adjacent non-malignant samples up-regulated expression Our results indicated that lncRNA HOTTIP was highly expressed in CRC compared with adjacent non-malignant tissues (P<0.001), and positively correlated with T stage (T1-2 vs. T3-4, P = 0.001), clinical stage (I-II stages vs. III-IV stages, P = 0.003), and distant metastasis (absent vs. present, P = 0.014) in CRC patients. Furthermore, we also observed that increased lncRNA HOTTIP expression was an unfavorable prognostic factor in CRC patients (P = 0.001), regardless of T stage, distant metastasis and clinical stage. Finally, overexpression of lncRNA HOTTIP was supposed to be an independent poor prognostic factor for CRC patients through multivariate analysis (P = 0.017). 26617875 Lnc2Cancer
EL0582 HOTTIP osteosarcoma qPCR, knockdown etc osteosarcomas tissues and matched adjacent non-tumor tissues, cell lines(MG-63, HOS) up-regulated expression We found that HOTTIP expression was up-regulated in OS tissues, and correlated with advanced clinical stage and distant metastasis. OS patients with high HOTTIP expression level had poorer overall survival than those with low HOTTIP expression. Multivariable Cox proportional hazards regression analysis suggested that increased HOTTIP expression was an independent prognostic factor of overall survival in OS patients. Moreover, the results of in vitro assays showed that the suppression of HOTTIP in OS cells significantly reduced cell proliferation, migration and invasion ability 26617868 Lnc2Cancer
EL0582 HOTTIP hepatocelluar carcinoma qPCR, Luciferase reporter assay etc. cell lines (BEL7402, MHCC97H, MHCC97H-Luc) up-regulated regulation In our profiling study, HOTTIP was identified as the most significantly up-regulated lncRNA in human HCCs, even in early stage of HCC formation. HOTTIP is a novel oncogenic lncRNA, which negatively regulated by miR-125b. Overexpression of HOTTIP contributes to hepatocarcinogenesis by regulating the expression of its neighboring protein-coding genes. 25424744 Lnc2Cancer
EL0582 HOTTIP hepatocelluar carcinoma qPCR, Western blot, knockdown etc. HCC tissue, cell lines (SNU182, SNU449, SNU423, SNU387, SNU475 etc.) up-regulated expression Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. 24114970 LncRNADisease Lnc2Cancer
EL0582 HOTTIP colorectal cancer qPCR, Western blot, knockdown etc. CRC and adjacent non-tumor colorectal samples, cell lines (DLD-1, SW480, SW620, HCT116) up-regulated interaction We found that overexpression of HOTTIP is correlated with an advanced pathological stage and a larger tumor size. Moreover, functional analyses revealed that the knockdown of HOTTIP expression by small interfering RNA (siRNA) or small hairpin RNA (shRNA) could inhibit cell proliferation and induce cell apoptosis. More importantly, we observed that HOTTIP knockdown induced a marked increase in the number of cells in the G0/G1 phase and a reduction in the number of cells in the S phase in both DLD-1 cells and SW480 cells. An in vivo experiment also revealed that the knockdown of HOTTIP inhibited tumor growth. Western blot and immunohistochemistry analyses indicated that HOTTIP potentially contributed to CRC cell growth partially through the silencing of p21 expression. 26678886 Lnc2Cancer
EL0582 HOTTIP hirschsprung disease qRT-PCR, Small RNA interference colon tissues rom 79 patients with Hirschsprung disease (HSCR) down-regulated expression LncRNA HOTTIP and HOXA13 were significantly down-regulated in HSCR compared to the controls. Meanwhile, the declined extent of their expression levels makes sense between two main phenotype of HSCR. Our study demonstrates that aberrant reduction of HOTTIP and HOXA13, which have a bidirectional regulatory loop, may play an important role in the pathogenesis of HSCR. 26043692
EL0582 HOTTIP prostate cancer sciliencing or knockdown of HOTTIP prostate cancer tumorigenesis down-regulated N/A down-regulation of HOTTIP and HOXA13 was associated with cell growth and cell cycle. 27064878
EL0583 Hottip skin cancer qPCR, lncRNA array analysis cultured mouse keratinocytes after deleting the vitamin D receptor (VDR) (∼90%) vs. control cells up-regulated expression protect by vitamin D receptor 24342142
EL0584 HOXA11-AS ovarian cancer qPCR, Western blot etc. ovarian cancer tissue down-regulated mutation Functional studies of ectopic expression of HOXA11-AS minor allele T in EOC cells showed decreased survival, proliferation, migration, and invasion compared to common allele A expression. Additionally, stable expression of HOXA11-AS minor allele T reduced primary tumor growth in mouse xenograft models to a greater extent than common allele A. Furthermore, HOXA11-AS expression levels were significantly lower in human EOC tumors than normal ovarian tissues (p < 0.05), suggesting that HOXA11-AS has a tumor suppressor function in EOC which may be enhanced by the T allele 26430965 Lnc2Cancer
EL0586 HOXA13 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. HCC tissue, cell lines (SNU182, SNU449, SNU423, SNU387, SNU475 etc.) up-regulated expression lncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. 24114970 LncRNADisease Lnc2Cancer
EL0588 HOXA-AS2 gastric cancer microarray, qPCR, Western blot, Luciferase reporter assay etc. gastric cancer tissue, cell lines (BGC823, SGC7901, AGS) up-regulated interaction Here, we reported that HOXA cluster antisense RNA2 (HOXA-AS2), a 1048bp RNA, was upregulated in GC. Increased HOXA-AS2 expression in GC was associated with larger tumor size and higher clinical stage; patients with higher levels of HOXA-AS2 expression had a relatively poor prognosis. HOXA-AS2 could be an oncogene for GC partly through suppressing P21, PLK3, and DDIT3 expression; HOXA-AS2 may be served as a candidate prognostic biomarker and target for new therapies in human GC. 26384350 Lnc2Cancer
EL0589 Hoxaas3 Idiopathic pulmonary fibrosis overexpression a mouse model of pulmonary injury and progressive interstitial fibrosis via intraperitoneal injection of paraquat, a widely used herbicide known to cause pulmonary fibrosis in human. up-regulated interaction Overexpression of uc.77 or 2700086A06Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. 26824344
EL0593 Hsromega polyglutamine diseases RNA interference N/A down-regulated interaction Loss of hsromega-n RNA not only suppresses the eye-specific degeneration mediated by GMR-GAL4 driven expression of the 127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene, but also rescues premature death of flies expressing the expanded polyQ proteins pan-neuronally using the elav-GAL4 driver. 19667761
EL0596 HTT-AS Huntington's disease N/A N/A N/A expression Levels of HTTAS_v1 are reduced in human HD frontal cortex. In cell systems, overexpression of HTTAS_v1 specifically reduces endogenous HTT transcript levels, while siRNA knockdown of HTTAS_v1 increases HTT transcript levels. 21672921 LncRNADisease
EL0597 HTTAS_v1 Huntington's disease N/A N/A N/A regulation Long ncRNA HTTAS_v1 is regulating the expression of Hungtiontonin (HTT) and is potentially involved in the development of HD. 24624135 LncRNADisease
EL0600 HULC diffuse large B-cell lymphoma in a cohort of DLBCL DLBCL tissues and cell lines up-regulated N/A HULC was closely related to DLBCL characteristics 27044827
EL0600 HULC papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. 25997963 Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma microarray, qPCR, knockdown etc. cell lines (HepG2, Huh7 etc.) up-regulated N/A The relative expression level of HULC, as determined by qPCR, was about 8-fold higher in HCC samples than in normal liver tissue. Depletion of IGF2BP1 led to an increased HULC half-life and higher steady-state expression levels, indicating a post-transcriptional regulatory mechanism. Importantly, HULC represents the first IGF2BP substrate that is destabilized. To elucidate the mechanism by which IGF2BP1 destabilizes HULC, the CNOT1 protein was identified as a novel interaction partner of IGF2BP1. CNOT1 is the scaffold of the human CCR4-NOT deadenylase complex, a major component of the cytoplasmic RNA decay machinery. Indeed, depletion of CNOT1 increased HULC half-life and expression. Thus, IGF2BP1 acts as an adaptor protein that recruits the CCR4-NOT complex and thereby initiates the degradation of the lncRNA HULC. 23728852 Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma microarray, qPCR, Northern blot, ISH, knockdown etc. HCC tissue, blood up-regulated expression Highly up-regulated in liver cancer. 17241883 LncRNADisease Lnc2Cancer
EL0600 HULC prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0600 HULC glioma N/A glioma patient tissues up-regulated N/A positively correlated with grade dependency in glioma patient tissues 26894862
EL0600 HULC atherosclerosis N/A liver cancer up-regulated N/A HULC regulated TNF-α-induced apoptosis through regulation of miR-9 expression 26981838
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A expression A similar genome-wide differential expression screen in hepatocellular carcinoma (HCC) has uncovered another cancer-associated lncRNA, Highly Upregulated in Liver Cancer, or HULC. 20951849 LncRNADisease
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A expression The lncRNA HULC is one of the most upregulated of all genes in hepatocellular carcinoma. 21802130 LncRNADisease
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A expression Dysregulation and functional roles of lncRNAs in HCC 24183851 LncRNADisease
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A regulation Here we focus on two best-characterized lncRNAs-HULC and LALR, which can impact proliferation through targeting various key regulators in different pathways. 24296588 LncRNADisease
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A regulation Moreover, HULC correlated with upregulated hepatitis B virus X protein (HBx) that importantly contributes to HCC and that was able to promote HULC expression. The HULC-mediated downregulation of the tumor suppressor p18 supported the HCC proliferation. 24531795 LncRNADisease
EL0600 HULC liver cancer N/A N/A N/A expression The highly upregulated lncRNA HULC in liver cancer was found in the blood of HCC patients, promising a potential biomarker. 24531795 LncRNADisease
EL0600 HULC liver cancer N/A N/A N/A N/A PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 4) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer. 24667321 LncRNADisease
EL0600 HULC hepatocelluar carcinoma N/A N/A N/A regulation A lncRNA, highly upregulated in liver cancer (HULC), was found to contribute to tumorigenesis of HCC. 24757675 LncRNADisease
EL0600 HULC colorectal cancer qPCR etc. cell lines (HepG2, Hep3B, SKOV3 etc.) up-regulated expression HULC expression is not confined to HCC, but also to those colorectal carcinomas that metastasize to the liver. 19445043 LncRNADisease Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma qPCR etc. HCC tissue up-regulated N/A In this study, we demonstrate that HULC expression is significantly higher in HCC tumors compared to normal liver tissues. Among the tumor tissues, higher HULC expression is positively associated with Edmondson histological grades or with hepatitis B (HBV) positive status. Moreover, HULC lncRNA is detected with higher frequency in the plasma of HCC patients compared to healthy controls. Higher HULC detection rates are observed in the plasma of patients with higher Edmondson grades or with HBV+ status. 23762823 Lnc2Cancer
EL0600 HULC osteosarcoma qPCR etc. osteosarcoma tissue, cell lines(MG-63, U2OS, SAOS-2 etc.) up-regulated expression In the present study, we demonstrated that HULC was significantly up-regulated in osteosarcoma tissues and cell lines compared with normal controls, and over-expression of HULC was correlated with clinical stage and distant metastasis. Moreover, higher HULC expression was associated with shorter overall survival of osteosarcoma patients.e, decreased expression of HULC markedly suppressed osteosarcoma cell proliferation, migration, and invasion. 26045809 Lnc2Cancer
EL0600 HULC gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. 26096073 Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma qPCR etc. blood (plasma), HCC tissue up-regulated expression Circulating HULC and Linc00152 were significantly up-regulated in plasma samples of HCC patients during training set and validation set. 26356260 Lnc2Cancer
EL0600 HULC pancreatic cancer qPCR, knockdown etc. pancreatic cancer tissue, cell lines (MIAPace-2, CFPAC-1, PANC-1, AsPC-1 etc.) up-regulated expression The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion. Multivariate analyses revealed that HULC expression served as an independent predictor for overall survival. Further experiments revealed that HULC knockdown significantly repressed cell proliferation of PC in vitro. 25412939 Lnc2Cancer
EL0600 HULC liver cancer qPCR, Luciferase reporter assay, Western blot etc. liver cancer tissue, cell lines (CREB, HULC, Prkacb etc.) up-regulated expression Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role in tumorigenesis. Depletion of HULC resulted in a significant deregulation of several genes involved in liver cancer. Although up-regulation of HULC expression. 20423907 LncRNADisease Lnc2Cancer
EL0600 HULC gastric cancer qPCR, Western blot etc. gastric cancer tissue, cell lines (GES-1, SGC7901, MKN28, MKN45, AGS, BGC823 etc.) up-regulated N/A In the present study, we demonstrated that HULC was significantly overexpressed in GC cell lines, compared with normal controls, and this overexpression was correlated with lymph node metastasis, distant metastasis and advanced tumor node metastasis stages.Additionally, HULC contributed to the malignant phenotype of GC cells through its regulation of diverse cellular processes, including proliferation, apoptosis, migration and invasion. 24247585 Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (MHCC97L, HepG2, cHL-7702) up-regulated expression The expression of HEIH and HULC in hepatocellular carcinoma cell line was significantly increased compared with human normal hepatocyte line (P<0.05). The expression of HULC in HepG2 was higher than that in MHCC97L. The over-expression of HULC could enhance proliferation of MHCC97L and HepG2, however, the over-expression of HEIH could not. The over-expression of HULC and HEIH could promote invasion of MHCC97L and HepG2. Invasion of MHCC97L and HepG2 did not have significant change after down-regulating of HEIH and HULC by siRNA. Over-expression of HULC up-regulated the expression of Snail in HepG2. 26550214 Lnc2Cancer
EL0600 HULC liver cancer qPCR, Western blot, knockdown, ChIP, Luciferase reporter assay etc. HCC tissue, cell lines (HepG2, Huh7, HepG2.2.15 etc.) up-regulated interaction Levels of HULC were positively correlated with levels of SPHK1 and its product, sphingosine-1-phosphate (S1P), in patients HCC samples. HULC increased SPHK1 in hepatoma cells. Mechanistically, HULC activated the promoter of SPHK1 in hepatoma cells through the transcription factor E2F1. Chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assay (EMSA) further showed that E2F1 was capable of binding to the E2F1 element in the SPHK1 promoter. HULC increased the expression of E2F1 in hepatoma cells and levels of HULC were positively correlated with those of E2F1 in HCC tissues. Intriguingly, HULC sequestered miR-107, which targeted E2F1 mRNA 3'UTR, by complementary base pairing. Functionally, si-SPHK1 remarkably abolished the HULC-enhanced tumor angiogenesis in vitro and in vivo. Taken together, we conclude that HULC promotes tumor angiogenesis in liver cancer through miR-107/E2F1/SPHK1 signaling. 26540633 Lnc2Cancer
EL0600 HULC hepatocellular carcinoma qPCR, Western blot, Luciferase reporter assay etc. HCC tissue, cell lines (L-O2 cell line, L-O2-X) up-regulated expression Our data show that an lncRNA, HULC, is responsible for the perturbations in circadian rhythm through upregulating circadian oscillator CLOCK in hepatoma cells, resulting in the promotion of hepatocarcinogenesis. Mechanistically, the complementary base pairing between HULC and the 5'untranslated region of CLOCK mRNA underlay the HULC-modulated expression of CLOCK, and the mutants in the complementary region failed to achieve the event. 25622901 Lnc2Cancer
EL0600 HULC hepatocelluar carcinoma qPCR, Western bolt, Luciferase reporter assayRIP etc. liver cancer tissue, cell lines (Panc1, MiaPaCa2, Panc28, L3.6pl etc.) up-regulated N/A We found that the expression levels of HULC were positively correlated with those of HBx in clinical HCC tissues. Moreover, we revealed that HBx up-regulated HULC in human immortalized normal liver L-O2 cells and hepatoma HepG2 cells. Luciferase reporter gene assay and chromatin immunoprecipitation (ChIP) assay showed that HBx activated the HULC promoter via cAMP-responsive element-binding protein. We further demonstrated that HULC promoted cell proliferation by methyl thiazolyl tetrazolium, 5-ethynyl-2'-deoxyuridine, colony formation assay, and tumorigenicity assay. Then, we validated that HULC down-regulated p18, which was involved in the HULC-enhanced cell proliferation in vitro and in vivo. In a word, HULC play function through regulating a tumor suppressor gene p18 located near HULC in the same chromosome. 22685290 Lnc2Cancer
EL0600 HULC HBV-related liver cirrhosis RT-qPCR, RIP HBV-related liver cirrhosis patients up-regulated expression We confirmed the effects of HULC on Tregs differentiation in HBV-related liver cirrhosis. In addition, it was proved that HULC regulates the function of Tregs through down-regulated the level of p18 directly. 25952928
EL0600 HULC hepatocelluar carcinoma TaqMan SNP array etc. HCC tissue differential expression mutation We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1 Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance. 22493738 LncRNADisease Lnc2Cancer
EL0601 human immunodeficiency virus-encoded antisense RNA HIV pcr, suppression N/A N/A epigenetics This viral expressed antisense lncRNA is involved in modulating human immunodeficiency virus gene expression and that this regulatory effectis due to an alteration in the epigenetic landscape at the viral promoter. It functions as an epigenetic brake to modulate viral transcription. 24576854
EL0604 HYMAI transient neonatal diabetes mellitus N/A N/A N/A expression In TNDM fibroblasts, the monoallelic expression of both ZAC and HYMAI is relaxed, providing strong supportive evidence that the presence of two unmethylated alleles of this locus is indeed associated with the inappropriate gene expression of neighbouring genes. 11935319 LncRNADisease
EL0605 ICR hepatocelluar carcinoma microarray, qPCR etc. HCC tissue, cell lines(CSQT-2, Huh7, Hep3B) up-regulated interaction Compared with the corresponding primary tumors, PVTT expressed different lncRNAs and mRNAs, including the up-regulated lncRNA ICR and ICAM-1. ICR regulated ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation, which modulated the CSC properties of ICAM-1+ HCC cells. ICR transcription in ICAM-1+ HCC cells was regulated by Nanog and inhibition of ICR in situ significantly reduced ICAM-1 expression and ICAM-1+ HCC cells in tumors in vivo. Moreover, elevated ICR and ICAM-1 expression in tumors was correlated with PVTT development and poor clinical outcomes 26667486 Lnc2Cancer
EL0607 IFNG-AS1 Sjögren syndrome N/A CD4(+) T cells of 25 Sjögren syndrome (SS) patients and 25 healthy donors up-regulated expression The level of expression of TMEVPG1 was correlated with the level of SSA, ESR and IgG. 26440590
EL0607 IFNG-AS1 Hashimoto's Thyroiditis N/A Twenty-eight HT patients and 20 healthy controls up-regulated interaction Enhanced expression of lncRNA-IFNG-AS1 contributes to Th1 cell response in HT patients and may be involved in the pathogenesis of HT. 26634912
EL0607 IFNG-AS1 multiple sclerosis N/A N/A N/A N/A Tmevpg1 (IFNG-AS1) is another lncRNA that may be involved in MS. 12719555 LncRNADisease
EL0608 IGF2-AS type 1 diabetes mellitus N/A N/A N/A mutation Association identified by GWAS. 17554260 LncRNADisease
EL0608 IGF2-AS prostate cancer N/A N/A N/A mutation Association identified by GWAS. 19767753 LncRNADisease
EL0608 IGF2-AS Wilms' tumor qPCR, Northern blot etc. Wilms' tumor tissue up-regulated expression PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively. 10731720 LncRNADisease Lnc2Cancer
EL0608 IGF2-AS Wilms' tumor qPCR, Northern blot etc. Wilms' tumor tissue down-regulated N/A IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues. In Wilms' tumors that demonstrate maintenance of imprinting of IGF2, IGF2-AS was imprinted. 12702581 LncRNADisease Lnc2Cancer
EL0608 IGF2-AS liver cancer qPCR, Northern blot etc. liver cancer tissue up-regulated expression Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. 12702581 LncRNADisease Lnc2Cancer
EL0608 IGF2-AS hepatocelluar carcinoma qPCR, Southern blot etc. SMMC-7721 cell line differential expression N/A IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. 12603530 LncRNADisease Lnc2Cancer
EL0611 INTS7 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0618 IPW Prader-Willi syndrome N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0618 IPW Prader-Willi syndrome N/A N/A N/A expression Subsequently, we determined that IPW, along?noncoding?RNA?in the critical region of the PWS locus, is a regulator of the DLK1-DIO3 region, as its overexpression in PWS and parthenogenetic iPSCs resulted in downregulation of MEGs in this locus.? 24816254 LncRNADisease
EL0618 IPW Prader-Willi syndrome N/A N/A N/A locus IPW (Imprinted gene in the Prader-Willi syndrome region) was isolated using the direct selection method and yeast artificial chromosomes localized to the deletion region. the mRNA product of IPW may play a role in the imprinting process. 7849716 LncRNADisease
EL0618 IPW Prader-Willi syndrome N/A N/A N/A expression The Prader-Willi syndrome (PWS) is caused by genomic alterations that inactivate imprinted, paternally expressed genes in human chromosome region 15q11-q13. IPW, a paternally expressed gene cloned from this region, is not expressed in individuals with PWS. 9063754 LncRNADisease
EL0619 IRAIN non small cell lung cancer knockdown non-small cell lung cancer (NSCLC) tissues up-regulated expression Knockdown of IRAIN suppressed NSCLC cells proliferation in vitro. 26722412
EL0619 IRAIN breast cancer qPCR etc. breast cancer tissue down-regulated locus In breast cancer tissues, we found that IRAIN lncRNA was transcribed from an intronic promoter in an antisense diretcion as compared to the IGF1R coding mRNA. Unlike the IGF1R coding RNA, this non-coding RNA was imprinted, with monoallelic expression from the paternal allele. IRAIN was aberrantly imprinted in both tumours and peripheral blood leucocytes, exhibiting a pattern of allele-switch: the allele expressed in normal tissues was inactivated and the normally imprinted allele was expressed. 25465188 Lnc2Cancer
EL0619 IRAIN acute myeloid leukemia qPCR, Northern blot, in vitro knockdown, ChIP etc. blood, cell lines (K562, KG-1, KG-1a, HL60, TF1) down-regulated interaction We demonstrate that this lncRNA interacts with chromatin DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop. In addition, IRAIN was downregulated both in leukemia cell lines and in blood obtained from high-risk AML patients. Activating the IGF1R gene, lead to growth advantage and tumor progression. 25092925 Lnc2Cancer
EL0620 JADRR breast cancer microarray, qPCR, Western blot, in vitro knockdown, RIP etc. breast cancer tissue, cell lines (293T, NIH3T3, MCF7, 4T1-luciferase etc.) up-regulated N/A Markedly higher levels of lncRNA-JADE were observed in human breast tumours in comparison with normal breast tissues. Knockdown of lncRNA-JADE significantly inhibited breast tumour growth in vivo. 24097061 Lnc2Cancer
EL0623 Kcna2-AS neuropathic pain N/A N/A N/A regulation A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. 23792947 LncRNADisease
EL0624 KCNE2 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue down-regulated N/A LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. 25765901 LncRNADisease Lnc2Cancer
EL0627 KCNQ1DN Wilms' tumor qPCR etc. Wilms' tumor tissue down-regulated expression A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors. 11056398 LncRNADisease Lnc2Cancer
EL0628 KCNQ1OT1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A locus KvDMR1 and/or its associated antisense RNA (KvLQT1-AS) represents an additional imprinting control element or center in the human 11p15.5 and mouse distal 7 imprinted domains. 10393948 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A locus The LIT1 CpG island can act as a negative regulator in cis for coordinate imprinting at the centromeric domain, thereby suggesting a role for the LIT1 locus in a BWS pathway leading to functional inactivation of p57(KIP2). 10958646 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A epigenetics The 5'end of the KCNQ1OT1 gene is hypomethylated in the Beckwith-Wiedemann syndrome. 12136243 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A N/A In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. 12746837 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A locus In the human and mouse BWS imprinting regions, two major elements for regulation of imprinted gene expression have been identified athe imprinting centers IC1 and IC2.IC2 appears to be the promoter of the paternally expressed probably noncoding transcript. 15590939 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A N/A LIT1 (KCNQ1OT1) may play a role in Beckwith-Wiedemann syndrome. 15888726 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A epigenetics In Beckwith-Wiedemann syndrome (BWS), approximately 50% of patients show loss of DNA methylation accompanied by loss of histone H3 Lys9 dimethylation on maternal KCNQ1OT-DMR, namely an imprinting disruption, leading to diminished expression of CDKN1C. 16575194 LncRNADisease
EL0628 KCNQ1OT1 colorectal cancer N/A N/A N/A expression Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT4: colorectal cancer). 23660942 LncRNADisease
EL0628 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
EL0628 KCNQ1OT1 kidney cancer N/A N/A N/A regulation Oncogene 24373479 LncRNADisease
EL0628 KCNQ1OT1 acute myocardial infarction N/A N/A N/A N/A Level of KCNQ1OT1 was higher in patients with MI than in healthy volunteers (P<0.01);Patients with ST-segment-elevation MI had lower levels of KCNQ1OT1 (P<0.001)when compared with patients with non-ST-segment-elevation 25035150 LncRNADisease
EL0628 KCNQ1OT1 colorectal cancer overexpression colorectal cancer cells up-regulated N/A β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter 26868975
EL0628 KCNQ1OT1 hepatocelluar carcinoma qPCR etc. HCC tissue differential expression mutation A novel tetranucleotide repeat polymorphism within KCNQ1OT1 confers risk for hepatocellular carcinoma. 23984860 LncRNADisease Lnc2Cancer
EL0628 KCNQ1OT1 colorectal cancer qPCR, FISH etc. CRC tissue, cell lines (FBS, DLD-1, HCT-15 etc.) differential expression epigenetics epigenetic disruption 16965397 LncRNADisease Lnc2Cancer
EL0628 KCNQ1OT1 breast cancer RNA CISH etc. breast cancer tissue up-regulated expression HOTAIR, H19 and KCNQ1OT1 had significantly higher expression levels in IBC than NA, and HOTAIR and H19 were both expressed more strongly in IBC than in DCIS tissues. 26323944 Lnc2Cancer
EL0633 KRAS1P cancer N/A N/A N/A regulation Similarly, KRAS and KRAS1P transcript levels were found to be positively correlated, corroborating that pseudogene functions mirror the role of their cognate genes as explained by the miRNA decoy mechanism.? 24757675 LncRNADisease
EL0634 KRT18P55 gastric cancer N/A GC cell lines (SGC-7901, MGC-803, BGC-823, AGS, and HG27) and 97 GC tissue up-regulated N/A upregulation was observed in GC cell lines 26855593
EL0635 KRT19P3 bladder cancer microarray, qPCR, knockdown etc. bladder cancer tissue up-regulated N/A Four lncRNAs were selected for further confirmation of microarray results using qPCR. These lncRNAs were among the most downregulated or upregulated lncRNAs. Data analysis showed that KRT19P3 was upregulated and TNXA, CTA-134P22.2 and CTC-276P9.1 were downregulated in bladder cancer samples compared with matched normal tissues.these deregulated lncRNAs play a key or partial role in the development and/or progression of bladder cancer. 24944692 Lnc2Cancer
EL0637 LA16c-313D11.11 endometrial cancer N/A endometrial cancer (EC) down-regulated interaction Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. 26807189
EL0638 LALR hepatocelluar carcinoma N/A N/A N/A regulation Here we focus on two best-characterized lncRNAs-HULC and LALR, which can impact proliferation through targeting various key regulators in different pathways. 24296588 LncRNADisease
EL0639 LBX2-AS1 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A We chose the lncRNAs AK096725 (upregulated) and ENST00000453068 (downregulated) to confirm their differential expression levels in 70 paired RCC tissues and adjacent non-tumor tissues. Levels of AK096725 were significantly greater in RCC tissues while those of ENST00000453068 was significantly lower compared to the non-tumor tissues. These results are consistent with the microarray data. 24905231 Lnc2Cancer
EL0640 LCAL1 lung cancer RNA-Seq, qPCR, knockdown etc. lung cancer tissue up-regulated expression Stable overexpression of LCAL1, using two different clones, in the control cell line BEAS-2B showed a significant increase in cellular proliferation starting on day 2 and continuing until the end of the experiment at day 6 with a 38% and 43% growth increase, respetcively. Overexpression of LCAL1 in normal BEAS-2B cells is proof of principle that this lncRNA is sufficient to affetc cellular growth independently of other common cancer mutations, thus highlighting the importance of LCAL1 in lung cancer biology. 25116943 Lnc2Cancer
EL0642 LDMAR photoperiod-sensitive male sterility N/A N/A N/A N/A A lncRNA of 1,236 bases in length, referred to as long-day-specific male-fertility-associated RNA (LDMAR), regulates PSMS (photoperiod-sensitive male sterility) in rice. 22308482 LncRNADisease
EL0644 LEIGC gastric cancer microarray, qPCR, in vitro knockdown etc. gastric cancer tissue, cell lines (MGC-803, AGS, SGC-7901) up-regulated expression We found that there were significantly lower levels of LEIGC expression in gastric cancer tissue. Overexpression of LEIGC suppressed tumor growth and cell proliferation, and enhanced the sensitivity of gastric cancer cells to 5-fluorouracil (5-FU), whereas knockdown of LEIGC showed the opposite effetc. We further demonstrated LEIGC functions by inhibiting the epithelial-to-mesenchymal transition (EMT) in gastric cancer. 25496320 Lnc2Cancer
EL0645 LGALS3 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0646 LINC00032 narcolepsy N/A N/A N/A mutation Association identified by GWAS. 16826516 LncRNADisease
EL0646 LINC00032 melanoma N/A N/A N/A mutation An analysis of genome-wide DNA copy number alterations in melanoma tumors revealed the loss of the C9orf14 locus, located proximal to CDKN2A, in approximately one-fourth of tumors. 17099875 LncRNADisease
EL0647 LINC00160 breast cancer Single-molecule sequencing, chromatin immunoprecipitation and quantitative real-time PCR luminal A-type human breast cancer cell lines MCF7 and T47D up-regulated interaction Silencing of LINC00160 results in reduced proliferation, demonstrating that lncRNA expression have functional consequences. 26423156
EL0648 LINC00173 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) down-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL0649 LINC00210 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) up-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL0650 LINC00237 MOMO (macrosomia, obesity, macrocephaly, and ocular abnormalities) syndrome Expression study in lymphocytes of control and case individuals MOMO patient up-regulated expression LINC00237 was expressed in lymphocytes of control individuals while normal transcripts were absent in lymphocytes of our MOMO patient. 23034868
EL0651 LINC00261 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression Furthermore, the levels of LINC00261 and TP73-AS1 were significantly differently expressed in subgroups of NSCLC samples.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL0651 LINC00261 gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) down-regulated expression Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. 26237576 Lnc2Cancer
EL0651 LINC00261 pancreatic cancer qPCR, Western blot, knockdown etc. PDAC tissue down-regulated expression The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR. 25910082 Lnc2Cancer
EL0652 LINC00271 schizophrenia N/A N/A N/A mutation This gene is associated with susceptibility to schizophrenia. 16773125 LncRNADisease
EL0652 LINC00271 type 2 diabetes mellitus N/A N/A N/A mutation Association identified by GWAS. 17668382 LncRNADisease
EL0653 LINC00299 neurodevelopmental disabilities DNA capture followed by next-generation sequencing all tissues ,most abundantly in brain N/A N/A these subjects with disruption of LINC00299 implicate this particular noncoding RNA in brain development and raise the possibility that, as a class, abnormalities of lincRNAs may play a significant role in human developmental disorders. 23217328
EL0653 LINC00299 intellectual and developmental disability N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0654 LINC00312 nasopharyngeal carcinoma microarray, ISH etc. NPC, TMA tissue down-regulated expression Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. 23529758 LncRNADisease Lnc2Cancer
EL0654 LINC00312 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression The expression level of ADAMTS9-AS2, C1401f132 and LINC00312 in NSCLC tumors were indeed significantly down-regulated when compared with those in normal lung tissues, while LINC00673 was significantly up-regulated in NSCLC tumors compared with normal lung tissues.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL0654 LINC00312 nasopharyngeal carcinoma N/A N/A N/A expression NAG-7 is a novel gene downregulated in human nasopharyngeal carcinoma. 11780420 LncRNADisease
EL0654 LINC00312 nasopharyngeal carcinoma Northern blot, Western blot etc. HNE1 cell line down-regulated expression NAG7 (LINC00312) gene re-expression could inhibit overproliferation of NPC cell by delaying the progression of G1 into S in cell cycle and inducing cell apoptosis. 12452030 LncRNADisease Lnc2Cancer
EL0654 LINC00312 nasopharyngeal carcinoma qPCR, Western blot, Luciferase reporter assay, ISH etc. cell line (HNE1) up-regulated Interaction NAG7 (LINC00312) promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. 19591174 LncRNADisease Lnc2Cancer
EL0655 LINC00313 lung cancer microarray, qRT-PCR tissues from 181 early-stage lung cancer patients up-regulated expression Notably, a novel lncRNA, LINC00313, was highly expressed in both T2- and N1-stage lung cancers. On the other hand, LINC00313 was also upregulated in lung cancer and metastasized lung cancer tissues, compared with adjacent lung tissues and primary lung cancer tissues. LINC00313 could be a biomarker for lung cancer. 26178480
EL0657 LINC00467 neuroblastoma microarray, qPCR, Luciferase reporter assay, knockdown etc. cell lines (BE(2)-C ) differential expression N/A Chromatin immunoprecipitation and luciferase assays showed that N-Myc suppressed linc00467 gene expression through direct binding to the linc00467 gene promoter and reducing linc00467 promoter activity. While N-Myc suppressed the expression of RD3, the protein-coding gene immediately down-stream of linc00467 gene, through direct binding to the RD3 gene promoter and reducing RD3 promoter activity, linc00467 reduced RD3 mRNA expression. Importantly, knocking-down linc00467 expression with siRNA in neuroblastoma cells reduced the number of viable cells and increased the percentage of apoptotic cells, and co-transfection with DKK1 siRNA blocked the effects. 24586304 Lnc2Cancer
EL0658 LINC00473 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL0659 LINC00491 pancreatic ductal adenocarcinoma microarray, qPCR etc. PDAC tissue down-regulated expression We found that the expression level of lncRNA BC008363 was significantly lower (23-fold) in PDAC tissues compared to corresponding nontumor pancreatic tissues, and patients with high levels of lncRNA BC008363 expression had significantly better survival rates than those with low levels of lncRNA BC008363 expression. lncRNA BC008363 may be a novel biomarker for the prognosis of pancreatic cancer. 25200694 Lnc2Cancer
EL0660 LINC00538 cancer N/A N/A N/A expression Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers. 22258142 LncRNADisease
EL0662 LINC00581 West Syndrome N/A N/A N/A mutation A de novo balanced t(2;6)(p15;p22.3) in a patient with West Syndrome disrupts a lnc-RNA, BX118339. 22245136 LncRNADisease
EL0662 LINC00581 West Syndrome N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL0663 LINC00635 non-small cell lung cancer microarray, qRT-PCR gefitinib-sensitive HCC827 cells and gefitinib-resistant HCC827-8-1 cells up-regulated interaction Silencing of LINC00635-001 alone did not remarkably impact HCC827-8-1 cells, but its combination with gefitinib treatment inhibited Akt activation and sensitized HCC827-8-1 cells to gefitinib-induced cytotoxicity. 26792719
EL0664 LINC00659 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0666 LINC00668 gastric cancer knockdown n vitro and in vivo up-regulated N/A LINC00668 knockdown significantly repressed proliferation, both in vitro and in vivo 27036039
EL0667 LINC00673 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression The expression level of ADAMTS9-AS2, C1401f132 and LINC00312 in NSCLC tumors were indeed significantly down-regulated when compared with those in normal lung tissues, while LINC00673 was significantly up-regulated in NSCLC tumors compared with normal lung tissues.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL0668 LINC00850 Duchenne muscular dystrophy N/A N/A N/A mutation Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28 23223008 LncRNADisease
EL0668 LINC00850 Duchenne muscular dystrophy N/A N/A N/A expression KUCG1 is a 648-bp nuclear lncRNA expressed in a tissue specific manner. Since it is normally expressed in the brain, its deregulation could contribute to the neurological impairment of the patient as already reported for other pathologies. 24685002 LncRNADisease
EL0670 LINC00901 osteosarcoma microarray, qPCR, FISH etc. osteosarcoma tissue, cell lines (U2OS, SAOS-2, HOS etc.) down-regulated mutation These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. 20048075 LncRNADisease Lnc2Cancer
EL0670 LINC00901 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue down-regulated N/A LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. 25765901 LncRNADisease Lnc2Cancer
EL0670 LINC00901 breast cancer qPCR etc. breast cancer tissue, cell lines (ZR-75-30, MCF-7, SKBR-3, T47D cells) down-regulated expression It showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status and tumor differentiation. Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer. 25435812 Lnc2Cancer
EL0671 LINC00942 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL0672 LINC00951 esophageal squamous cell carcinoma biochemical assays N/A N/A N/A functional polymorphism rs11752942A>G in lincRNA-uc003opf.1 exon might be a genetic modifier for the development of ESCC. 23872665
EL0673 LINC00963 prostate cancer microarray, qPCR, knockdown, Western blot etc. cell lines (LNCaP ,C4-3) up-regulated regulation Linc00963: a novel, long non-coding RNA involved in the transition of prostate cancer from androgen-dependence to androgen-independence. 24691949 LncRNADisease Lnc2Cancer
EL0674 LINC00964 colorectal cancer qPCR etc. CRC tissue down-regulated interaction Furthermore, the authors observed that mRNA expression levels of LNC00964-3 were significantly lower in CRC tissues than in corresponding normal tissues. The current findings reveal the possibility that piR-015551 may be generated from LNC00964-3, which may be involved in the development of CRC 25740697 Lnc2Cancer
EL0675 LINC00970 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL0676 LINC00974 hepatocelluar carcinoma qPCR, in vitro knockdown, RIP etc. HCC tissue, blood(plasma) up-regulated interaction Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro.The combination of Linc00974 and KRT19 may be novel indices for clinical diagnosis of tumor growth and metastasis in HCC, while Linc00974 may become a potential therapeutic target for the prevention of HCC progression. We also discovered Linc00974F-1 stably expressed in the plasma. 25476897 Lnc2Cancer
EL0677 LINC00982 gastric cancer qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, AGS, MKN45) down-regulated interaction In this study, we identified a novel lncRNA LINC00982, whose expression was downregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, knockdown of LINC00982 expression by small interfering RNA (siRNA) could promote cell proliferation and cell cycle progression, while ectopic expression of LINC00982 inhibited cell proliferation and rendered cell cycle arrest in GC cells partly via regulating P15 and P16 protein expressions. 26334618 Lnc2Cancer
EL0678 LINC00987 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0679 LINC01016 breast cancer Single-molecule sequencing, chromatin immunoprecipitation and quantitative real-time PCR luminal A-type human breast cancer cell lines MCF7 and T47D up-regulated expression LINC01016 and LINC00160 are direct transcriptional targets of ERα, correlate with Erα expression in clinical samples, and show prognostic significance in relation to breast cancer survival. 26423156
EL0680 LINC01018 hepatocelluar carcinoma qPCR etc. HCC tissue, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) down-regulated mutation We found that a lower SRHC expression level was significantly more frequent in tissues with a high serum a-fetoprotein level and a low degree of differentiated tumors. Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. 25512078 Lnc2Cancer
EL0681 LINC01021 colorectal cancer RNA-seq, pSILAC, qPCR, Western Blot, Luciferase reporter assay etc. cell line (SW480) up-regulated interaction Ectopic LINC01021 expression inhibited proliferation in SW480 cells. 26183718 Lnc2Cancer
EL0682 LINC01024 lung cancer qPCR, Western blot, knockdown etc. cell lines (H1299) up-regulated interaction We employed qPCR to analyze MA-linc1 levels in four cell lines: U2OS and H1299 cells, as well as the human embryonic lung fibroblasts, WI38, and another human osteosarcoma cell line, SAOS-2, each expressing the conditionally active E2F1. This analysis demonstrated that activation of the ectopic E2F1 resulted in a significant increase in MA-linc1 RNA levels in all four cell lines. 26337085 Lnc2Cancer
EL0682 LINC01024 osteosarcoma qPCR, Western blot, knockdown etc. cell lines (U2OS, SAOS-2) up-regulated expression We employed qPCR to analyze MA-linc1 levels in four cell lines: U2OS and H1299 cells, as well as the human embryonic lung fibroblasts, WI38, and another human osteosarcoma cell line, SAOS-2, each expressing the conditionally active E2F1. This analysis demonstrated that activation of the ectopic E2F1 resulted in a significant increase in MA-linc1 RNA levels in all four cell lines. 26337085 Lnc2Cancer
EL0683 SLC44A3-AS1 colorectal cancer microarray, qPCR etc. blood (plasma) up-regulated expression The expression of three lncRNAs in plasma of CRC were all significantly higher than those in controls. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future. 26328256 Lnc2Cancer
EL0684 LINC01105 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue down-regulated N/A LncRNA M59227 and 3 mRNAs, PLK1, PTTG1 and VCAN, were overexpressed in GC. In contrast, the expression of 4 lncRNAs, LOC150622, AKR7 L, DQ192290 and BC040587, and 2 mRNAs, DRD5 and GDF5, were downregulated in GC.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. 25765901 LncRNADisease Lnc2Cancer
EL0685 LINC01125 uremia microarray assay, qRT-PCR peripheral blood mononuclear cells of uremia patients N/A expression Differential expression of ZAP70 and BC133674 (ZAP70-ncRNA) was confirmed by RT-PCR. 23100179
EL0686 LINC01133 lung squamous cell carcinoma microarray, qPCR, knockdown etc. NSCLC tissue, cell lines (H1703) up-regulated N/A LSCC patients with higher expression level of LINC01133 had shorter survival time. LINC01133 is upregulated in lung squamous cell cancer and predicts survival 25908174 LncRNADisease Lnc2Cancer
EL0687 LINC01158 gastric cancer microarray, qRT-PCR peripheral blood regulatory T cells (T-reg) in gastric cancer up-regulated interaction linc-POU3F3 could promote the distribution of Tregs in peripheral blood T cell which caused an enhanced cell proliferation of gastric cancer cells by recruiting TGF-beta as well as activating TGF-beta signal pathway. 26807174
EL0688 LINC01207 lung adenocarcinoma qPCR, Western blot, knockdown, RIP, ChIP etc. NSCLC tissues and adjacent non-tumor tissues, cell lines(A549) up-regulated interaction LINC01207 was significantly up-regulated in LAD tissues compared with paired non-tumor tissues, while there was no significant differences between LSCC tissues and adjacent non-tumor tissues. The expression level of LINC01207 was associated with TNM stage of LAD patients, and higher LINC01207 level indicated advanced TNM stage and shorter survival. 26693067 Lnc2Cancer
EL0689 LINC01225 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We discovered three lncRNA, RP11-160H22.5, XLOC_014172 and LOC149086, which were up-regulated in HCC comparing with the cancer-free controls. RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction and XLOC_014172 and LOC149086 for metastasis prediction in the future. 25714016 Lnc2Cancer
EL0690 LINC01233 esophageal squamous cell carcinoma microarray, qPCR etc. OSCC tissue differential expression N/A we identified a three-lncRNA signature (including the lncRNAs ENST00000435885.1, XLOC_013014 and ENST00000547963.1) which classified the patients into two groups with significantly different overall survival . The signature was applied to the test group (median survival 21.5 months vs >60 months, p=0.0030) and independent cohort (median survival 25.8 months vs >48 months, p=0.0187) and showed similar prognostic values in both. 24522499 Lnc2Cancer
EL0691 LINC01262 Parkinson's disease N/A N/A N/A expression These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing sequence complementarity to numerous microRNAs. 24651478 LncRNADisease
EL0692 LINC01315 nasopharyngeal carcinoma microarray, qPCR etc. NPC tissue up-regulated expression Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients 24822202 LncRNADisease Lnc2Cancer
EL0693 LINC01370 type 2 diabetes mellitus N/A N/A N/A regulation Depletion of HI-LNC25, a 尾 cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility. 23040067 LncRNADisease
EL0694 LINC01419 hepatocelluar carcinoma microarray, qPCR etc. HBV-related HCC tissue up-regulated expression Four upregulated lncRNAs were randomly selected and analyzed for their expression levels in tissue samples from 14 HBV-related HCC patients. The corresponding non-tumor tissues were analyzed via qPCR, in which the obtained results are consistent with the microarray data. 26109807 Lnc2Cancer
EL0694 LINC01419 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We noted that LINC01419 was characterized by a significant increase in transcript expression from dysplasia to early HCC. The lncRNA AK021443 was also up-regulated in advanced HCC samples when compared with early HCC. Moreover, expression of LINC01419 and AK021443 was up-regulated in HCC tissues when compared with non-tumor liver tissue. AF070632 expression was down-regulated in HCC and was decreased in advanced HCC when compared with early HCC. These results suggest that LINC01419 may be related to the initiation of HCC, whereas AK021443 and AF070632 may be associated with the progression of HCC. 26540467 Lnc2Cancer
EL0695 LINC01426 esophageal squamous cell carcinoma qPCR, Luciferase reporter assay, Western blot etc. ESCC tissue up-regulated expression We found that lincRNA-uc002yug.2 was commonly overexpressed in ESCC. Moreover, lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPa (CCAAT/enhancer-binding protein-a) gene expression, thereby promoting ESCC progression. The expression levels of lincRNA-uc002yug.2 in ESCC might be a prognostic factor for survival. 25486427 Lnc2Cancer
EL0696 LINC01433 lung cancer microarray, qPCR, Western blot, knockdown etc. cell line (16HBE) up-regulated N/A LOC728228 was upregulated relative to its expression in control untransformed16HBE (16HBE-N) cells. 25820656 LncRNADisease Lnc2Cancer
EL0697 LINC01451 hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue up-regulated N/A AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. 21769904 Lnc2Cancer
EL0698 LINC01468 tongue squamous cell carcinoma microarray, qPCR etc. tongue SCC tissue up-regulated regulation Overexpression of lnc-SPRR2D-1 and lnc-PPP2R4-5 was found in the tongue SCC tissue. Overexpression of the lnc-MBL2-4:3 in the tongue SCC was highly significant in comparison with the paired normal epithelia. Lnc-AL355149.1-1 was the only lncRNA found to be downregulated in the tongue SCC tissues.The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC. 25045670 Lnc2Cancer
EL0699 LINC01503 tongue squamous cell carcinoma microarray, qPCR etc. tongue SCC tissue up-regulated regulation Overexpression of lnc-SPRR2D-1 and lnc-PPP2R4-5 was found in the tongue SCC tissue. Overexpression of the lnc-MBL2-4:3 in the tongue SCC was highly significant in comparison with the paired normal epithelia. Lnc-AL355149.1-1 was the only lncRNA found to be downregulated in the tongue SCC tissues.The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC. 25045670 Lnc2Cancer
EL0700 LINC01511 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression RP11-133F8.2 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly higher than wild-type EGFR tissues, while LOC440905 expression of EGFR exon 19 deletions in lung adenocarcinoma was significantly lower than wild-type EGFR tissues. RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. 25085781 Lnc2Cancer
EL0701 LINC01512 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0702 LINC01527 tongue squamous cell carcinoma microarray, qPCR etc. tongue SCC tissue up-regulated regulation Overexpression of lnc-SPRR2D-1 and lnc-PPP2R4-5 was found in the tongue SCC tissue. Overexpression of the lnc-MBL2-4:3 in the tongue SCC was highly significant in comparison with the paired normal epithelia. Lnc-AL355149.1-1 was the only lncRNA found to be downregulated in the tongue SCC tissues.The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC. 25045670 Lnc2Cancer
EL0703 LINC01550 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue down-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL0704 LINC01564 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL0706 LINC01616 Alzheimer's disease Gene set enrichment analysis postmortem tissue samples of AD patients down-regulated expression lncRNA n341006 in association with protein ubiquitination pathway 26318290
EL0707 LINC01617 colorectal cancer microarray, qPCR etc. blood (plasma) up-regulated expression The expression of three lncRNAs in plasma of CRC were all significantly higher than those in controls. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future. 26328256 Lnc2Cancer
EL0708 LINC01618 colorectal cancer microarray, qPCR etc. blood (plasma) of CRC tissue up-regulated expression The expression of three lncRNAs in plasma of CRC were all significantly higher than those in controls. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future. 26328256 Lnc2Cancer
EL0709 LINC01628 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression We discovered that three lncRNAs (RP11-397D12.4, AC007403.1, and ERICH1-AS1) were up regulated in NSCLC, compared with cancer-free controls. RP11-397D12.4, AC007403.1, and ERICH1-AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future. 26393913 Lnc2Cancer
EL0710 LINC01630 colorectal cancer qPCR etc. colorectal cancer tissue down-regulated expression The qRT-PCR results revealed the misregulation of these genes during tumorigenesis. Their relative expression levels were significantly lower in tumor tissues than adjacent tumor-free tissues. However, the analysis found no significant correlation between reduced expression of these genes 26429648 Lnc2Cancer
EL0710 LINC01630 colorectal cancer Quantitativereal-time-PCR (qRT-PCR) colorectal tissue down-regulated N/A LOC100287225 expressed in the intestinal tissue 27062707
EL0715 linc-CBR1-2 lung cancer microarray, qPCR, knockdown etc. lung cancer tissue up-regulated N/A To validate our findings, we selected one lincRNA and three mRNAs for validation. Of these, linc-CBR1-2, and two mRNAs, RAB25 and HMBG3 were up-regulated in AIS compared to nomal tisssu. 24735754 Lnc2Cancer
EL0718 linc-ITGB1 breast cancer qPCR, Western blot, knockdown, Flow cytometry assay etc. breast cancer tissue, cell lines (MDA-MB-231, MCF-7, T47D, ZR-75-30, 1590 etc.) up-regulated interaction The expression of linc-ITGB1 was significantly upregulated in both clinical breast cancer tissues and cultured breast cancer cell lines. Linc-ITGB1 depletion caused cell accumulation in the G0/G1 phase. Furthermore, the linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. These data suggest that linc-ITGB1 promotes breast cancer progression by inducing cell-cycle arrest and interrupting the epithelial-to-mesenchymal transition (EMT) process. 26601916 Lnc2Cancer
EL0719 LINCMD1 Duchenne muscular dystrophy N/A N/A N/A expression Interestingly, the levels of linc-MD1 are strongly reduced in primary myoblasts of DMD patients and its ectopic expression rescues the myogenic differentiation potential of these cells, restoring the correct expression pattern of MAML1, MEF2C, MYOG and MHC. 24685002 LncRNADisease
EL0721 LINC-PINT colorectal cancer microarray, qPCR, RIP etc. cell lines (KrasLA2/+, Trp53LSL/LSL, Rosa26-CreERT2 etc.) down-regulated N/A In this study, we have identified and characterized the lincRNA named Pint, abona fidep53 transcriptional target that acts as negative modulator of the p53 response.We found a significant downregulation of PINT in colorectal tumors compared with normal tissue, suggesting a potential role of the lincRNA as a tumor suppressor. Pint binds directly to PRC2, and is required for the targeting of PRC2 to specific genes for H3K27 tri-methylation and repression. Of the total number of genes affected by Pint inhibition, 39% were upregulated and 61% downregulated upon Pint knockdown. 24070194 Lnc2Cancer
EL0721 LINC-PINT heart failure N/A N/A N/A expression Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure.The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. 24663402 LncRNADisease
EL0739 lincRNA-BC2 breast cancer RNA-seq, qPCR etc. breast cancer tissue up-regulated expression We analyzed lincRNAs whose expression was significantly different between cancer tissues and adjacent tissues. LincRNA-BC2 and lincRNA-BC5 were consistently up-regulated more than 2-fold (mean∮SD) in cancer samples. Whereas, lincRNA-BC4 and lincRNA-BC8 were down-regulated.They might play important roles in the function of oncogenes or tumor suppressors affecting the development and progression of breast cancer. 25084155 Lnc2Cancer
EL0740 lincRNA-BC4 breast cancer RNA-seq, qPCR etc. breast cancer tissue down-regulated expression We analyzed lincRNAs whose expression was significantly different between cancer tissues and adjacent tissues. LincRNA-BC2 and lincRNA-BC5 were consistently up-regulated more than 2-fold (mean∮SD) in cancer samples. Whereas, lincRNA-BC4 and lincRNA-BC8 were down-regulated.They might play important roles in the function of oncogenes or tumor suppressors affecting the development and progression of breast cancer. 25084155 Lnc2Cancer
EL0741 lincRNA-BC5 breast cancer RNA-seq, qPCR etc. breast cancer tissue up-regulated expression We analyzed lincRNAs whose expression was significantly different between cancer tissues and adjacent tissues. LincRNA-BC2 and lincRNA-BC5 were consistently up-regulated more than 2-fold (mean∮SD) in cancer samples. Whereas, lincRNA-BC4 and lincRNA-BC8 were down-regulated.They might play important roles in the function of oncogenes or tumor suppressors affecting the development and progression of breast cancer. 25084155 Lnc2Cancer
EL0742 lincRNA-BC8 breast cancer RNA-seq, qPCR etc. breast cancer tissue down-regulated expression We analyzed lincRNAs whose expression was significantly different between cancer tissues and adjacent tissues. LincRNA-BC2 and lincRNA-BC5 were consistently up-regulated more than 2-fold (mean∮SD) in cancer samples. Whereas, lincRNA-BC4 and lincRNA-BC8 were down-regulated.They might play important roles in the function of oncogenes or tumor suppressors affecting the development and progression of breast cancer. 25084155 Lnc2Cancer
EL0743 lincRNA-CALCA hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) down-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL0744 lincRNA-LALR1 liver cancer qPCR, RIP etc. liver cancer tissue up-regulated regulation LncRNA-LALR1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/尾-Catenin signaling 23483581 LncRNADisease Lnc2Cancer
EL0745 lincRNA-TSPAN8 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) down-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. Among them, lincRNA-TSPAN8 and TSPAN8 were found highly expressed in high lung metastatic potential HCC cells, while lowly expressed in no or low lung metastatic potential HCC cells. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL0746 lincRNA-ZNF532 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) up-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL0747 LINC-ROR triple-negative breast cancer microarray, qPCR, Western blot etc. breast cancer tissue, cell lines (HEK293T, MCF-7, HS578T, MDA-MB-231) up-regulated N/A LincRNA-RoR is upregulated in TNBC and in metastatic disease and knockdown restores miR-145 expression.The lincRNA-RoR/miR-145/ARF6 pathway is critical to TNBC metastasis and could serve as biomarkers or therapeutic targets for improving survival. 25253741 LncRNADisease Lnc2Cancer
EL0747 LINC-ROR hepatocelluar carcinoma qPCR, Luciferase reporter assays, knockdown etc. cell lines (HepG2, PLC-PRF5) up-regulated N/A lincRNA-ROR (linc-ROR), a stress-responsive lncRNA was highly expressed in HCC cells and enriched within extracellular vesicles derived from tumor cells. Incubation with HCC-derived extracellular vesicles increased linc-ROR expression and reduced chemotherapy-induced cell death in recipient cells. Sorafenib increased linc-ROR expression in both tumor cells and extracellular vesicles, whereas siRNA to linc-ROR increased chemotherapy-induced apoptosis and cytotoxicity. 24918061 Lnc2Cancer
EL0747 LINC-ROR breast cancer qPCR, vivo knockdown, PIR etc. breast cancer tissue up-regulated N/A linc-ROR was upregulated in breast tumor and ectopic overexpression of linc-ROR in immortalized human mammary epithelial cells induced an epithelial-to-mesenchymal transition (EMT) program. Moreover,linc-ROR enhanced breast cancer cell migration and invasion. Linc-ROR was associated with miRNPs and functioned as a competing endogenous RNA to mi-205. linc-ROR functions as an important regulator of EMT and can promote breast cancer progression and metastasis through regulation of miRNAs. 24922071 Lnc2Cancer
EL0747 LINC-ROR colorectal cancer qPCR, Western blot, knockdown etc. cell lines (HT29, HRT-18) up-regulated interaction we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
EL0747 LINC-ROR malignant melanoma qPCR, Western blot, knockdown etc. cell lines (OM431, MUM2B) up-regulated expression we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
EL0747 LINC-ROR gastric cancer qPCR, Western blot, knockdown etc. cell line (AGS) up-regulated expression we found that the expression of ROR was significantly increased in a series of tumor cells, whereas all of the negative controls remained weakly expressed. 26169368 Lnc2Cancer
EL0747 LINC-ROR pancreatic cancer qRT-PCR, RNA interference approaches, luciferase assays and RNA binding protein immunoprecipitation, immunohistochemistry assay 61 paired cancerous and noncancerous tissue samples, pancreatic cancer stem cells (PCSCs) up-regulated expression Knockdown of ROR by RNA interference in PCSCs inhibited proliferation, induced apoptosis and decreased migration. Moreover, ROR silencing resulted in significantly decreased tumourigenicity of PCSCs in nude mice than controls. 26636540
EL0747 LINC-ROR liver cancer RT-PCR, knockdown N/A up-regulated interaction linc-RoR is a hypoxia-responsive lncRNA that is functionally linked to hypoxia signaling in HCC through a miR-145-HIF-1α signaling module. 24463816
EL0750 LINK-A triple-negative breast cancer N/A N/A N/A interaction Both LINK-A expression and LINK-A-dependent signalling pathway activation correlate with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis. 26751287
EL0752 Llme23 melanoma qPCR, Western bolt, Northern bolt, knockdown, RIP etc. cell lines (MCF10A, HEK293, A2058, SKmel28, YU-SIT1, YUSAC etc.) differential expression N/A The specific binding of Llme23 to both recombinant and native PSF protein was confirmed in vitro and in vivo. The expression of PSF-binding Llme23 is exclusively detected in human melanoma lines. Knocking down Llme23 remarkably suppressed the malignant property of YUSAC cells, accompanied by the repressed expression of proto-oncogene Rab23. These results may indicate that Llme23 can function as an oncogenic RNA and directly associate the PSF-binding lncRNA with human melanoma. 23618401 Lnc2Cancer
EL0753 lnc13 celiac disease N/A small intestinal biopsy samples from patients with down-regulated N/A Lnc13 regulates gene expression by binding to hnRNPD a member of a family of ubiquitously expressed heterogeneous nuclear 27034373
EL0758 Lnc34a colon cancer N/A colon cancer stem cells (CCSCs) up-regulated N/A Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously 27077950
EL0760 lnc-ACACA-1 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0761 lnc-AF085935 hepatocelluar carcinoma qPCR etc. blood (serum) up-regulated expression The level of serum lncRNA-uc003wbd and lncRNA-AF085935 was significantly upregulated in HCC patients and HBV patients compared with that in normal controls.In addition, higher expressions of lncRNAs were observed in HCC patients than in HBV patients. LncRNA-uc003wbd and lncRNA-AF085935 were observed with an aberrant serum level in HCC and HBV patients, which is showing that both lncRNA-uc003wbd and lncRNA-AF085935 are able to be potential biomarkers for HCC and HBV screening. 25501706 Lnc2Cancer
EL0762 lnc-AL355149.1-1 nasopharyngeal carcinoma microarray, qPCR etc. NPC tissue up-regulated expression Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients 24822202 LncRNADisease Lnc2Cancer
EL0762 lnc-AL355149.1-1 tongue squamous cell carcinoma microarray, qPCR etc. tongue SCC tissue down-regulated regulation Overexpression of lnc-SPRR2D-1 and lnc-PPP2R4-5 was found in the tongue SCC tissue. Overexpression of the lnc-MBL2-4:3 in the tongue SCC was highly significant in comparison with the paired normal epithelia. Lnc-AL355149.1-1 was the only lncRNA found to be downregulated in the tongue SCC tissues.The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC. 25045670 Lnc2Cancer
EL0763 lncARSR sunitinib resistance N/A renal cell carcinoma (RCC). N/A N/A promoted sunitinib resistance via competitively binding miR-34/miR-449 facilitate AXL and c-MET expression in RCC cells 27117758
EL0764 lnc-bc060912 lung cancer qPCR, Northern blot, knockdown, RIP etc. cell lines (H1299, A549, 293T) up-regulated interaction Here we have identified a lncRNA termed Lnc-bc060912 whose expression is increased in human lung and other tumors. Lnc-bc060912 suppressed cell apoptosis. Lnc-bc060912 via PARP1 and NPM1, affects cell apoptosis and may play important roles in tumorigenesis and cancer progression. 25848691 Lnc2Cancer
EL0765 lnc-BMP2-2 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0766 lnc-CPN2-1 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0767 lnc-CYP4A22-2/3 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression lnc-ZNF180-2 levels were similar in localized ccRCC and normal renal tissue, but we observed a significant increase of lnc-ZNF180-2 expression in advanced ccRCC tissue. Furthermore, lnc-ZNF180-2 expression levels were an independent predictor of progression-free survival, cancer-specific survival and overall survival in ccRCC patients. We also observed that lnc-CYP4A22-2/3 expression levels allowed discrimination of ccRCC and normal renal tissue. In conclusion, lncRNAs are involved in renal carcinogenesis, and quantification of lnc-ZNF180-2 may be useful for the prediction of ccRCC patients outcome following nephrectomy. 26609485 Lnc2Cancer
EL0768 lnc-DILC liver cancer real-time PCR; pull down assay and oligoribonucleotides or oligodeoxynucleotides treatment N/A down-regulated interaction Depletion of lnc-DILC markedly enhanced LCSC expansion and facilitated HCC initiation and progression, whereas ectopic expression of lnc-DILC dramatically inhibited LCSC expansion. Mechanistically, lnc-DILC inhibited the autocrine IL-6/STAT3 signaling. 26812074
EL0769 lnc-FOXG1-2 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0770 lnc-FZD1-2 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0771 lnc-ITPR2-3 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0772 lnc-KCMF1-2:1 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0773 lnc-LCE5A-1 tongue cancer RNA-seq, qPCR etc. cell lines (UMSCC-10B, HN-12) down-regulated N/A We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. 25904139 LncRNADisease Lnc2Cancer
EL0773 lnc-LCE5A-1 pharyngeal cancer RNA-seq, qPCR etc. cell lines (HN-1, HN-30) down-regulated N/A We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. 25904139 LncRNADisease Lnc2Cancer
EL0773 lnc-LCE5A-1 laryngeal cancer RNA-seq, qPCR etc. cell lines (UMSCC-22B) down-regulated N/A We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. 25904139 LncRNADisease Lnc2Cancer
EL0774 lnc-LCP2-2 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0776 lnc-LLPH-2:1 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0777 lnc-MX1-1 prostate cancer real-time quantitative PCR, knockdown prostate cancer cells up-regulated expression There was a significant association between over-expression of lnc-MX1-1 and patients' clinical features such as PSA, Gleason score, metastasis, and recurrence free survival. knockdown of lnc-MX1-1 reduced both proliferation and invasiveness of LNCaP and 22Rv1 cells. 26797523
EL0778 lnc-PLA2R1-1:1 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0779 lnc-PSD4-1:14 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0791 lncRNA-422 colorectal cancer microarray, qPCR etc. CRC tissue up-regulated regulation Two of the lncRNAs, HOTAIR and a novel lncRNA, lncRNA-422 were confirmed in more samples. GSEA indicated that gene sets most correlated with them were those named up-regulated in KRAS-over, down-regulated in JAK2-knockout, down-regulated in PDGF-over and down-regulated in TBK1-knockout, all of which were cancer-related. Subsequently, GO analyses of most significantly correlated coding genes of HOTAIR and lncRNA-422 showed that these two lncRNAs may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer. 25456707 Lnc2Cancer
EL0797 lncRNA-AK058803 breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue, cell lines (MCF-7) up-regulated interaction The expression levels of lncRNA-AK058003 were increased significantly in the breast cancer tissues and were found to strongly correlate with the severity of the breast cancer clinical stage. 26136884 Lnc2Cancer
EL0798 LncRNA-AP001631.9 gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (AGS, MGC803, BGC823, SGC7901) up-regulated expression The qRT-PCR data indicated that the LncRNA-AP001631.9 expression was frequently increased in gastric cancer tissues. The expression level of LncRNA-AP001631.9 was positively correlated with that of FOXM1. The transwell and wound healing assays indicated that LncRNA-AP001631.9 was required for the migration of gastric cancer cells. The downregulation of LncRNA-AP001631.9 by small interference RNA suppressed the migratory ability of MGC803 and AGS cells, while the overexpression of LncRNA-AP001631.9 promoted the movement of BGC823 and SGC7901 cells. 26261500 Lnc2Cancer
EL0799 lncRNA-ATB hepatocelluar carcinoma immunohistochemistry quantitative RT-PCR analysis keloid tissue and keloid fibroblasts N/A N/A lncRNA-ATB governs the autocrine secretion of TGF-β2 in KFs 27090737
EL0799 lncRNA-ATB hepatocelluar carcinoma microarray, qPCR etc. HCC tissue, cell lines (SMMC-7721) up-regulated regulation Thus, these findings suggest that?lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies. 24768205 LncRNADisease Lnc2Cancer
EL0799 lncRNA-ATB colorectal cancer qPCR etc. CRC tissue up-regulated N/A High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases. 25750289 LncRNADisease Lnc2Cancer
EL0799 lncRNA-ATB gastric cancer qPCR etc. gastric cancer tissue, cell lines (MKN1, MKN7, MKN28, MKN45, MKN74 etc.) differential expression interaction The high lncRNA-ATB group experienced a lower overall survival rate compared with the low lncRNA-ATB group, and multivariate analysis indicated that lncRNA-ATB was an independent prognostic factor (hazard ratio 3.50; 95 % CI 1.73-7.44; p = 0.0004).LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGFb/miR-200s/ZEB axis, resulting in a poor prognosis in GC.LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients. 25986864 Lnc2Cancer
EL0799 lncRNA-ATB pancreatic cancer qPCR etc. pancreatic cancer and paired adjacent normal pancreatic tissues, cell lines (HPDE6c-7) down-regulated expression We found that lncRNA-ATB expression was decreased in pancreatic cancer tissues and pancreatic cancer cell lines. Low lncRNA-ATB expression levels were significantly correlated with lymph node metastases (yes vs. no, P = 0.009), neural invasion (positive vs. negative, P = 0.049), and clinical stage (early stage vs. advanced stage, P = 0.014). Moreover, patients with low lncRNA-ATB expression levels exhibited markedly worse overall survival prognoses (P < 0.001). Multivariate analysis indicated that decreased lncRNA-ATB expression was an independent predictor of poor prognosis in pancreatic cancer patients (P = 0.005). 26482611 Lnc2Cancer
EL0799 lncRNA-ATB colon cancer qPCR etc. colon cancer tissues up-regulated interaction LncRNA-ATB was upregulated in colon cancer tissues compared with adjacent mucosa. LncRNA-ATB levels were also higher in metastatic cancer tissues. Among the three highly invasive colon cancer cell lines, lncRNA-ATB levels were relatively higher with concurrent low levels of E-cad compared with levels in the three low-invasive cell lines. LncRNA-ATB expression correlated with pN stage and AJCC stage. Striking differences were observed in overall survival and disease-free survival in cases with both high lncRNA-ATB expression and low E-cad expression. Reduction of lncRNA-ATB increased expression of epithelial markers E-cad, ZO-1, and decreased expression of mesenchymal markers ZEB1 and N-cadherin (N-cad), and significantly influenced colon cancer cell progression. Plasma lncRNA-ATB was upregulated in colon cancer patients one month after surgery. 26487301 Lnc2Cancer
EL0800 lncRNA-DQ786227 lung cancer microarray, qPCR, in vitro knockdown etc. cell lines (A549, QG56 etc.) up-regulated N/A Expression of lncRNA-DQ786227 in both lung cancer cells differed from that in BEAS-2B cells. Expression of lncRNA-DQ786227 was significantly higher in the A549 and QG56 cells compared with the BEAS-2B cells.Our findings revealed that lncRNA-DQ786227 might act as an oncogene. Our study provides a new insight regarding the oncogenic properties of lncRNA in B[a]P-induced cell transformation. 24084393 Lnc2Cancer
EL0802 lncRNA-n336928 bladder cancer microarray, qPCR etc. bladder cancer tissue up-regulated expression Results showed that the expression level of lncRNA-n336928 (noncode database ID: n336928) was significantly higher in bladder cancer tissues compared to that in adjacent noncancerous tissues (P < 0.001). Collectively, our study shows that high expression of lncRNA-n336928 is associated with the progression of bladder cancer, and that lncRNA-n336928 might serve as a biomarker for prognosis of bladder cancer. 26551459 Lnc2Cancer
EL0805 lnc-RP3-368B9 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0806 lnc-SLC30A4-1 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0807 lnc-SPAM1-6 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue up-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0808 lnc-TTC34-3 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression Among these, aberrant expression was validated using PCR: lnc-BMP2-2, lnc-CPN2-1, lnc-FZD1-2, lnc-ITPR2-3, lnc-SLC30A4-1, and lnc-SPAM1-6 were highly overexpressed in ccRCC, whereas lnc-ACACA-1, lnc-FOXG1-2, lnc-LCP2-2, lnc-RP3-368B9, and lnc-TTC34-3 were downregulated. Computational analyses revealed that these lncRNAs are involved in RNA-protein networks related to splicing, binding, transport, localization, and processing of RNA. 25685243 Lnc2Cancer
EL0809 lnc-uc003wbd hepatocelluar carcinoma qPCR etc. blood (serum) up-regulated expression The level of serum lncRNA-uc003wbd and lncRNA-AF085935 was significantly upregulated in HCC patients and HBV patients compared with that in normal controls.In addition, higher expressions of lncRNAs were observed in HCC patients than in HBV patients. LncRNA-uc003wbd and lncRNA-AF085935 were observed with an aberrant serum level in HCC and HBV patients, which is showing that both lncRNA-uc003wbd and lncRNA-AF085935 are able to be potential biomarkers for HCC and HBV screening. 25501706 Lnc2Cancer
EL0810 lnc-ZNF180-2 clear cell renal cell carcinoma microarray, qPCR etc. ccRCC tissue down-regulated expression lnc-ZNF180-2 levels were similar in localized ccRCC and normal renal tissue, but we observed a significant increase of lnc-ZNF180-2 expression in advanced ccRCC tissue. Furthermore, lnc-ZNF180-2 expression levels were an independent predictor of progression-free survival, cancer-specific survival and overall survival in ccRCC patients. We also observed that lnc-CYP4A22-2/3 expression levels allowed discrimination of ccRCC and normal renal tissue. In conclusion, lncRNAs are involved in renal carcinogenesis, and quantification of lnc-ZNF180-2 may be useful for the prediction of ccRCC patients outcome following nephrectomy. 26609485 Lnc2Cancer
EL0811 lnc-ZNF674-1 nasopharyngeal carcinoma microarray, qPCR etc. NPC tissue up-regulated expression Results. In primary NPC, upregulation of?lnc-C22orf32-1,?lnc-AL355149.1-1, and?lnc-ZNF674-1 was observed. High levels of?lnc-C22orf32-1 and?lnc-AL355149.1-1 were significantly associated with the male patients 24822202 LncRNADisease Lnc2Cancer
EL0813 LOC100131831 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL0814 LOC100287482 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL0816 LOC100506974 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL0818 LINC01844 hirschsprung disease qRT-PCR to detect the relative expression of LOC101926975 in 80 pairs of HSCR bowel tissues and matched normal bowel tissues HSCR bowel tissues and matched normal bowel tissues down-regulated N/A Dysregulation of LOC101926975 suppressed cell proliferation and induced G0/G1 arrest without impact on cell apoptosis or migration 27076786
EL0819 LOC101927497 pediatric acute myeloid leukemia qRT-PCR three bone marrow samples obtained from each pediatric AML patient up-regulated interaction Dysregulated lncRNAs and mRNAs in pediatric AML versus normal controls that could form gene pathways to regulate cell cycle progression and immunoresponse. 26573779
EL0821 LOC103692984 sciatic nerve injury microarray analysis,quantitative real-time polymerase chain reaction and in situ hybridization, silencing Dorsal root ganglia (DRG) N/A N/A these 24 lncRNAs were found to be mainly involved in cell phenotype modulation, including glial cell migration, purinergic nucleotide receptor signaling pathway, vasodilation, regulation of multi-organism process, and neuropeptide signaling pathway, and also to be potentially associated with several key regeneration signaling pathways, including MAPK signaling pathway, and neuroactive ligand-receptor interaction,lncRNA had a particular promoting effect on neurite outgrowth. 23274483
EL0823 LOC105372753 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) up-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL0824 LOC105374631 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL0825 LOC105377769 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) down-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL0827 LOC389023 psychiatric disease N/A N/A N/A regulation Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels. 23831425 LncRNADisease
EL0828 LOC389332 clear cell renal cell carcinoma microarray, qPCR etc. renal clear cell carcinoma tissue down-regulated N/A ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). 22879955 Lnc2Cancer
EL0829 AC100861.1 pancreatic ductal adenocarcinoma knockdown, overexpression pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines up-regulated interaction Knockdown of LOC389641 impaired cell proliferation and invasion and induced cell apoptosis in vitro, whereas overexpression of LOC389641 had the opposite effect. LOC389641 promotes PDAC progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A. 26708505
EL0830 LOC400891 prostate cancer lncRNAs expression chips screening, quantitative real-time PCR (qRT-PCR) prostate cancer (Pca) tissues and cell lines up-regulated expression Knockdown of LOC400891 could inhibit cell proliferation, migration, and invasion in vitro study. 26797783
EL0831 LOC401317 nasopharyngeal carcinoma microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. cell lines (HNE2, HNE1, CNE2) up-regulated regulation LOC401317 was the most significantly upregulated lncRNA. Further studies indicated that LOC401317 is diretcly regulated by p53 and that etcopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. LOC401317 inhibited cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression and promoted apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage. 25422887 Lnc2Cancer
EL0833 LOC652276 colorectal cancer microarray, qPCR etc. cell lines (T29, SW480, RKO, Lovo, HCTll6) differential expression expression The radiosensitivity order of these 5 cell lines from low to high (SF2 value from high to low) was HT29, SW480, RKO, Lovo, HCT116. Among them, expression levels of R05532, NR_015441 and NR_033374 were positively correlated with radiation resistance(all P<0.01),which may be used as the predictiv marker of radiosensitivity of coloretcal cancer cells. 25421768 Lnc2Cancer
EL0835 Lrrc9 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 21 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL0836 LSINCT1 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0836 LSINCT1 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0837 LSINCT10 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0837 LSINCT10 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0838 LSINCT11 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0838 LSINCT11 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0839 LSINCT12 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0839 LSINCT12 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0840 LSINCT2 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0840 LSINCT2 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0841 LSINCT3 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0841 LSINCT3 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0842 LSINCT4 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0842 LSINCT4 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0843 LSINCT5 breast cancer N/A N/A N/A expression Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor 22817756 LncRNADisease
EL0843 LSINCT5 ovarian cancer N/A N/A N/A expression Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor 22817756 LncRNADisease
EL0843 LSINCT5 gastric cancer qPCR etc. gastric cancer tissue, cell lines (AGS, MKN-45, MGC-803, BGC-823, HGC-27) up-regulated N/A The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. In addition, increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. 25526476 LncRNADisease Lnc2Cancer
EL0843 LSINCT5 colorectal cancer qPCR etc. CRC tissue, cell lines (LoVo, Caco-2, DLD1,HCT-8, HCT-116) up-regulated N/A The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. Increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. Gastric cancer (GC) and colorectal cancer (CRC) patients with higher LSINCT5 expression levels have worse disease-free survival (DFS) and disease-specific survival (DSS) rates. 25526476 LncRNADisease Lnc2Cancer
EL0843 LSINCT5 gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. 25694351 Lnc2Cancer
EL0843 LSINCT5 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0843 LSINCT5 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0843 LSINCT5 breast cancer qPCR, Northern blot, etc. cell lines (HMEC, MCF7, MDA157 etc.) up-regulated expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. 21532345 LncRNADisease Lnc2Cancer
EL0843 LSINCT5 ovarian cancer qPCR, Northern blot, etc. cell lines (OVCAR5, NHBE etc.) up-regulated expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. 21532345 LncRNADisease Lnc2Cancer
EL0843 LSINCT5 breast cancer qPCR, Northern blot, knock-down, Microarray human bronchial epithelial (NHBE) cells, breast cancer cell line, ovarian cancer cell line up-regulated expression knock-down of LSINCT5 expression decreased proliferation in human breast and ovarian cancer cells; Using a genome tiling array to identify noncoding sequences upregulated in normal human bronchial epithelial (NHBE) cells exposed to a DNA-damaging tobacco carcinogen 26323562
EL0843 LSINCT5 ovarian cancer qPCR, Northern blot, knock-down, Microarray human bronchial epithelial (NHBE) cells, breast cancer cell line, ovarian cancer cell line up-regulated expression knock-down of LSINCT5 expression decreased proliferation in human breast and ovarian cancer cells; Using a genome tiling array to identify noncoding sequences upregulated in normal human bronchial epithelial (NHBE) cells exposed to a DNA-damaging tobacco carcinogen 26323562
EL0844 LSINCT6 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0844 LSINCT6 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0845 LSINCT7 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0845 LSINCT7 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0846 LSINCT8 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0846 LSINCT8 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0847 LSINCT9 breast cancer qPCR, Northern blot etc. cell lines (HMEC, HCC1500, HCC1569 etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0847 LSINCT9 lung cancer qPCR, Northern blot etc. cell lines (T47D, BT474, NCF10A etc.) up-regulated N/A Collectively, our results identified a new class of long stress responsive non-coding transcripts, LSINCTs, which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines, indicating that the expression is increased in both, correlating cellular stress and cancer. 20214974 Lnc2Cancer
EL0848 LUADT1 lung adenocarcinoma microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. lung cancer tissues and adjacent non-tumor tissues, cell lines ( A549, H1975, H358, H1650 and H1299A549, H1975, H358, H1650 and H1299 ) up-regulated interaction LUADT1 may regulate cell cycle progression by epigenetically inhibiting the expression of p27. RNA immunoprecipitation and chromatin immunoprecipitation assays confirmed that LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. The negative correlation between LUADT1 and p27 expression was confirmed in LUAD tissue samples. LUADT1 is an oncogenic lncRNA that regulates LUAD progression, suggesting that dysregulated lncRNAs may serve as key regulatory factors in LUAD progression 26291312 Lnc2Cancer
EL0849 LUCAT1 lung cancer qPCR, Western bolt, RIP etc. cell lines (A549, CL1-0, CL1-5, H1975, HCC-827, NCI-H292 etc.) up-regulated N/A We found that XLOC_004924 was elevated in the airway epithelia of cigarette smokers versus nonsmokers in both of these datasets. In the first dataset, five nonsmokers were compared with six smokers. In the second study, the smokers' epithelia demonstrated a 3.9-fold increase in XLOC_004924, compared with nonsmokers. Functionally,siRNA knockdown of SCAL1 in HBE1 cells shows significant potentiation of cytotoxicity induced by CSE in vitro. Altogether, these results identify a novel and intriguing new non-coding RNA that may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells. 23672216 Lnc2Cancer
EL0850 LUNAR1 diffuse large B-cell lymphoma Quantitative real-time PCR, knockdown Diffuse large B-cell lymphoma (DLBCL) tissues and cell lines N/A interaction The higher expression of LUNAR1 was significantly correlated with stage, rituximab and IPI. Univariate and multivariate analyses showed that LUNAR1 expression served as an independent predictor for overall survival and progression-free survival. LUNAR1 may serve as a candidate prognostic biomarker through growth regulation in DLBCL. 26796267
EL0850 LUNAR1 T cell acute lymphoblastic leukemia RNA-seq, qPCR etc. blood up-regulated interaction We have shown that one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. 25083870 Lnc2Cancer
EL0851 M14574 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue down-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL0852 MAFA-AS1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL0852 MAFA-AS1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL0853 MALAT1 paraspeckle disintegration Immunoprecipitation of Ribonucleoprotein Complex,knockdown HeLa cell down-regulated mutation Successful removal of MENepsilon/beta by a refined knockdown method resulted in paraspeckle disintegration. Furthermore, the reassembly of paraspeckles disassembled by transcriptional arrest appeared to be unsuccessful in the absence of MENepsilon/beta. 19188602
EL0853 MALAT1 lung cancer knockdown human bronchial epithelial (HBE) cells up-regulated interaction Cigarette smoke extract (CSE) caused decreases of miR-217 levels and increases in lncRNA MALAT1 levels. The CSE-induced increase of MALAT1 expression was blocked by an miR-217 mimic, indicating that miR-217 negatively regulates MALAT1 expression. 26415832
EL0853 MALAT1 breast cancer MALAT1-siRNA breast cancer tissues and cells up-regulated N/A MALAT1-siRNA inhibited breast cancer cell proliferation and cell cycle progression in vitro and in vivo; and downregulating miR-124 expression 26918449
EL0853 MALAT1 non-small cell lung cancer Meta-analysis non-small cell lung cancer and pancreatic cancer up-regulated expression From subgroup analyses,we present evidence that lncRNA MALAT1 overexpression was an unfavorable prognostic factor for patients' overall survival in non-small cell lung cancer and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and 1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a potential prognostic factor in human cancers. 26131129
EL0853 MALAT1 pancreatic cancer Meta-analysis non-small cell lung cancer and pancreatic cancer up-regulated expression From subgroup analyses,we present evidence that lncRNA MALAT1 overexpression was an unfavorable prognostic factor for patients' overall survival in non-small cell lung cancer and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and 1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a potential prognostic factor in human cancers. 26131129
EL0853 MALAT1 cervical cancer Microarray, knockdown, RT-PCR, western blot, and immunofluorescence cervical cancer (CC) cells and tissues up-regulated expression The down-regulation of MALAT1 by shRNA in CC cells inhibited the invasion and metastasis in vitro and in vivo. MALAT1 functions to promote cervical cancer invasion and metastasis via induction of EMT, and it may be a target for the prevention and therapy of cervical cancers. 26798987
EL0853 MALAT1 neuroblastoma microarray, qPCR etc. cell line (SK-N-SH ) down-regulated expression We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line. 20149803 LncRNADisease Lnc2Cancer
EL0853 MALAT1 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL0853 MALAT1 triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
EL0853 MALAT1 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. 25997963 Lnc2Cancer
EL0853 MALAT1 neuroblastoma microarray, qPCR, knockdown etc. cell lines (BE(2)-C, CHP134) up-regulated N/A Here we demonstrated that N-Myc up-regulated the expression of JMJD1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to the JMJD1A gene promoter. Affymetrix microarray studies revealed that the gene second most significantly up-regulated by JMJD1A was MALAT1. Consistent with this finding, RT-PCR and chromatin immunoprecipitation assays showed that JMJD1A bound to the MALAT1 gene promoter and demethylated histone H3K9 at the MALAT1 gene promoter. 24742640 Lnc2Cancer
EL0853 MALAT1 colon cancer microarray, qPCR, knockdown etc. blood, cell lines (SW480 and SW620) up-regulated regulation The stimulation of colon cancer progression by TADC-derived CCL5 was associated with the up-regulation of non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), which subsequently increased the expression of Snail. Blocking MALAT-1 significantly decreased the TADC-conditioned medium and CCL5-mediated migration and invasion by decreasing the enhancement of Snail, suggesting that the MALAT-1/Snail pathway plays a critical role in TADC-mediated cancer progression 25546229 Lnc2Cancer
EL0853 MALAT1 colorectal cancer microarray, qPCR, Western blot etc. CRC tissue, cell lines (HCT116, SW480, SW620, LoVo, CaCo-2 etc.) up-regulated regulation In the present study, we found that MALAT1 was up-regulated in human primary CRC tissues with lymph node metastasis. Knockdown of MALAT1 inhibited CRC tumor growth and metastasis. MALAT1 regulated at least 243 genes in CRC cells in a genome-wide expression profiling. Among these genes, PRKA kinase anchor protein 9 (AKAP-9) was significantly up-regulated at both mRNA and protein levels. AKAP-9 was highly expressed in CRC cells with metastatic potential and human primary CRC tissues with lymph node metastasis. 25446987 Lnc2Cancer
EL0853 MALAT1 glioma microarray, qPCR, Western blot, knockdown etc. cell line SHG139S down-regulated interaction Our results showed that downregulation of MALAT1 suppressed the expression of Sox2 and Nestin which are related to stemness, while downregulation of MALAT1 promoted the proliferation in SHG139S. Further research on the underlying mechanism showed that the effects of MALAT1 downregulation on SHG139S were through regulating ERK/MAPk signaling activity. And we also found that downregulation of MALAT1 could activate ERK/MAPK signaling and promoted proliferation in SHG139 cells. 26649728 Lnc2Cancer
EL0853 MALAT1 liver cancer microarray, qPCR, Western blot, Luciferase reporter assay, RIP etc. liver cancer tissue, cell lines (HepG2, Bel-7402, SMMC-7721, HEK-293T etc.) differential expression regulation Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer. 24468535 LncRNADisease Lnc2Cancer
EL0853 MALAT1 proliferative vitreoretinopathy Microarray, qRT-PCR biofluid of PVR (Proliferative VitreoRetinopathy) patients up-regulated expression MALAT1 was significantly up-regulated in the cellular and plasma fraction of peripheral blood in PVR patients. In vitro experiments revealed the role of MALAT1 in regulating RPE proliferation and migration, which is critical for ERMs formation. MALAT1 is a potential prognostic indicator and a target for the diagnosis and gene therapy for PVR diseases. 26241674
EL0853 MALAT1 non-small-cell lung cancer microarray, qRT-PCR tumor samples from 383 NSCLC patients N/A interaction Gene expression analysis of A549 adenocarcinoma cells with differential MALAT-1 lncRNA expression demonstrated an influence on the expression of Bcl-2 and its interacting proteins. 25036876
EL0853 MALAT1 non-small cell lung cancer N/A N/A N/A expression In NSCLC metastasizing tumors, MALAT-1 expression is three-fold higher than in non-metastasizing tumors. Furthermore, in patients with stage I disease, MALAT-1 expression is closely correlated with poor prognosis. 21550244 LncRNADisease
EL0853 MALAT1 hepatocellular carcinoma N/A hepatocellular carcinoma (HCC) tissues up-regulated interaction N/A 26352013
EL0853 MALAT1 breast cancer N/A breast cancer cells up-regulated N/A MALAT1 induced migration and invasion of breast cancer 26926567
EL0853 MALAT1 hepatocelluar carcinoma N/A N/A N/A expression HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC 17006932 LncRNADisease
EL0853 MALAT1 lung adenocarcinoma N/A N/A N/A expression Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. 19690017 LncRNADisease
EL0853 MALAT1 cancer N/A N/A N/A expression The expression of the long ncRNA MALAT1 correlates with tumor development, progression or survival in lung, liver and breast cancer. 20711585 LncRNADisease
EL0853 MALAT1 cancer N/A N/A N/A expression MALAT1 is a highly conserved long ncRNA originally identified as a transcript overexpressed in many cancers. 20864030 LncRNADisease
EL0853 MALAT1 osteosarcoma N/A N/A N/A expression Osteosarcoma patients' survival is significantly associated with MALAT-1 expression levels. 20951849 LncRNADisease
EL0853 MALAT1 non-small cell lung cancer N/A N/A N/A expression Specific lncRNAs can serve as predictors of tumor outcome, as shown with the expression of the lncRNA MALAT-1 in early-stage non-small cell lung cancer. 21903344 LncRNADisease
EL0853 MALAT1 breast cancer N/A N/A N/A regulation On a more mechanistic level, recent studies have revealed the contribution of lncRNAs as proto-oncogenes, e.g. GAGE6, as tumor suppressor genes, e.g. 鈥榩15 antisense RNA and lincP21' (36,91), as drivers of metastatic transformation, e.g. HOTAIR in breast cancer, and as regulators of alternative splicing, e.g. MALAT1 22492512 LncRNADisease
EL0853 MALAT1 hepatocelluar carcinoma N/A N/A N/A mutation We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1 Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance. 22493738 LncRNADisease Lnc2Cancer
EL0853 MALAT1 non-small cell lung cancer N/A N/A N/A expression lncRNA-associated disruption to alternative splicing has also been reported in non-small cell lung cancer by virtue of overexpression of MALAT1 22817756 LncRNADisease
EL0853 MALAT1 small cell lung cancer N/A N/A N/A expression For other LncRNAs, specific targets have yet to be identified. This is the case of MALAT1, a LncRNA whose expression is three times higher in metastasizing early-stage non-small cell lung cancer vs. non-metastasizing tumours 22928560 LncRNADisease
EL0853 MALAT1 breast cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 colon cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 liver cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 lung cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 osteosarcoma N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 pancreatic cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 prostate cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 uterus cancer N/A N/A N/A regulation Sequesters SR splicing factors to regulate alternative splicing. 22996375 LncRNADisease
EL0853 MALAT1 cancer N/A N/A N/A regulation MALAT1 (metastasis-associated lung adenocarcinoma transcript 1),another lncRNA associated with various cancers and metastasis (Ji et al. 2003; Lin et al. 2011)锛?, is found to affect the transcriptional and post-transcriptional regulation of cytoskeletal and extracellular matrix genes. 23463798 LncRNADisease
EL0853 MALAT1 decreased myogenesis N/A N/A N/A expression The myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis. 23485710 LncRNADisease
EL0853 MALAT1 cancer N/A N/A N/A expression MALAT1 is upregulated in several cancer types and its overexpression has been linked to an increase in cell proliferation and migration in lung and colorectal cancer cells. 23660942 LncRNADisease
EL0853 MALAT1 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL0853 MALAT1 hepatocelluar carcinoma N/A N/A N/A expression Dysregulation and functional roles of lncRNAs in HCC 24183851 LncRNADisease
EL0853 MALAT1 bladder cancer N/A N/A N/A regulation Oncogene 24373479 LncRNADisease
EL0853 MALAT1 kidney cancer N/A N/A N/A regulation Oncogene 24373479 LncRNADisease
EL0853 MALAT1 prostate cancer N/A N/A N/A regulation Putative marker 24373479 LncRNADisease
EL0853 MALAT1 diabetes mellitus N/A N/A N/A expression In addition, MALAT1, a conserved lncRNA, was significantly upregulated in an RF/6A cell model of hyperglycemia, in the aqueous humor samples, and in fibrovascular membranes of diabetic patients. 24436191 LncRNADisease
EL0853 MALAT1 breast cancer N/A N/A N/A regulation invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma 24499465 LncRNADisease
EL0853 MALAT1 lung cancer N/A N/A N/A regulation invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma 24499465 LncRNADisease
EL0853 MALAT1 uterus cancer N/A N/A N/A regulation invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma 24499465 LncRNADisease
EL0853 MALAT1 lung cancer N/A N/A N/A expression MALAT1, also known as NEAT2 (nuclear-enriched abundant transcript 2), was initially discovered as a predictive biomarker for metastasis development in lung cancer. 24667321 LncRNADisease
EL0853 MALAT1 tumor N/A N/A N/A regulation MALAT1 plays a role in cell migration and tumor metastasis, as demonstrated by knockout of MALAT1 in lung cancer cell lines (Gutschner et al., 2013). 24721780 LncRNADisease
EL0853 MALAT1 cancer N/A N/A N/A regulation They found that MALAT1 did not alter alternative splicing but rather actively regulated gene expression including a set of metastasis-associated genes. Consequently, MALAT1-deficient cells were impaired in migration and formed fewer tumor nodules in mouse xenograft. Antisense oligonucleotides (ASO) that block MALAT1 prevented metastasis formation after tumor implantation. 24757675 LncRNADisease
EL0853 MALAT1 cervical cancer N/A N/A N/A expression Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC. 24757675 LncRNADisease
EL0853 MALAT1 hepatocelluar carcinoma N/A N/A N/A expression Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC. 24757675 LncRNADisease
EL0853 MALAT1 lung cancer N/A N/A N/A expression Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC. 24757675 LncRNADisease
EL0853 MALAT1 laryngeal squamous cell carcinoma N/A N/A N/A expression The result suggested that the MALAT1 was up-regulated in primary LSCC compared with adjacent non-cancerous tissues. 24817925 LncRNADisease
EL0853 MALAT1 nasopharyngeal carcinoma N/A N/A N/A expression The result found that MALAT1 was most highly expressed in 5-8F cells (high rate to be tumor and metastasis), and up-regulated in CNE-2, C666-1 and HONE-1 which is higher malignant and poorly differentiated nasopharyngeal squamous cell carcinoma, while least expressed in NP69 epithelial cells of the eternal life. The data indicated that MALAT1 might be related to the metastasis and differentiation of NPC cells. 24817925 LncRNADisease
EL0853 MALAT1 acute myocardial infarction N/A N/A N/A N/A Level of metastasis-associated lung adenocarcinoma transcript 1 was higher in patients with MI than in healthy volunteers (P<0.01); Patients with ST-segment-elevation MI had lower levels of metastasis-associated lung adenocarcinoma transcript 1 (P=0.005) when compared with patients with non-ST-segment-elevation 25035150 LncRNADisease
EL0853 MALAT1 diabetes mellitus N/A N/A N/A N/A MALAT1 expression is significantly upregulated in the retinas of STZ-induced diabetic rats and db/db mice. MALAT1 knockdown could obviously ameliorate DR in vivo, as shown by pericyte loss, capillary degeneration, microvascular leakage, and retinal inflammation. Moreover, MALAT1 knockdown could regulate retinal endothelial cell proliferation, migration, and tube formation in vitro. The crosstalk between MALAT1 and p38 MAPK signaling pathway is involved in the regulation of endothelial cell function. 25356875 LncRNADisease
EL0853 MALAT1 glioblastoma N/A N/A N/A N/A Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1. 25772239 LncRNADisease
EL0853 MALAT1 non-small cell lung cancer qPCR etc. NSCLC tissue up-regulated expression Increased expression of the lncRNA MALAT-1 has been observed in several types of tumors, including metastatic non-small cell lung cancer. 12970751 LncRNADisease Lnc2Cancer
EL0853 MALAT1 osteosarcoma qPCR etc. osteosarcoma tissue up-regulated N/A The expression of MALAT-1, IMPDH2, FTL and RHOA significantly correlated with response to chemotherapy. Expression of all four genes was increased in the poor responder group that are valuable markers for the prediction of osteosarcoma therapy outcome. Especially IMPDH2 and FTL are promising candidates for the stratification of osteosarcoma patients into low- and high-risk groups. Owing to their involvement in drug action these genes may further be potential targets for the modulation of drug sensitivity. 17660802 Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR etc. cell line (CaSki) up-regulated Interaction MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL. 20213048 LncRNADisease Lnc2Cancer
EL0853 MALAT1 lung adenocarcinoma qPCR etc. cell line (A549 ) differential expression interaction MALAT-1 is a novel class of non-coding RNA that promotes cell motility of lung adenocarcinoma cells through transcriptional and post-transcriptional regulation of motility related gene expression. 20937273 LncRNADisease Lnc2Cancer
EL0853 MALAT1 colorectal cancer qPCR etc. CRC tissue, cell lines (SW620, SW480 etc.) differential expression N/A The 3' end of MALAT-1 is an important biological motif in the invasion and metastasis of CRC cells. 21503572 LncRNADisease Lnc2Cancer
EL0853 MALAT1 non-small cell lung cancer qPCR etc. cell lines (A549, plat-E, HTB-58 etc.) up-regulated expression The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. 22088988 LncRNADisease Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR etc. cell line (CaSki) down-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL0853 MALAT1 lung cancer qPCR etc. cell lines (A549, A549 MALAT1 KO, EBC-1 etc.) up-regulated regulation The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. 23243023 LncRNADisease Lnc2Cancer
EL0853 MALAT1 prostate cancer qPCR etc. prostate cancer tissue, cell lines (22RV1, LNCAP-AI etc.) up-regulated N/A MALAT-1 was up-regulated in human prostate cancer tissues and cell lines. Higher MALAT-1 expression correlated with high Gleason score, prostate specific antigen, tumor stage and castration resistant prostate cancer. MALAT-1 down-regulation by siRNA inhibited prostate cancer cell growth, invasion and migration, and induced castration resistant prostate cancer cell cycle arrest in the G0/G1 phases. 23845456 Lnc2Cancer
EL0853 MALAT1 non-small cell lung cancer qPCR etc. NSCLC tissue up-regulated N/A MALAT1 was shown to be detectable in the cellular fraction of peripheral human blood, showing different expression levels between cancer patients and cancer-free controls. For the discrimination of NSCLC patients from cancer-free controls a sensitivity of 56% was calculated conditional on a high specificity of 96%. The results of this study indicate that MALAT1 complies with key characteristics of diagnostic biomarkers, i.e., minimal invasiveness, high specificity, and robustness. 24313945 Lnc2Cancer
EL0853 MALAT1 pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated expression Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. 24469926 LncRNADisease Lnc2Cancer
EL0853 MALAT1 multiple myeloma qPCR etc. blood (plasma) down-regulated expression HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. 24583225 LncRNADisease Lnc2Cancer
EL0853 MALAT1 pancreatic ductal adenocarcinoma qPCR etc. PADC tissue, cell lines (Panc-1, Bxpc-3, HPDE6C-7 etc.) up-regulated N/A The relative level of MALAT1 was significantly higher in PDAC compared to the adjacent normal pancreatic tissues. When comparing the MALAT1 level in the cultured cell lines, remarkably higher expression of MALAT1 was found in aspc-1 PDAC cells compared with the immortal pancreatic duct epithelial cell line HPDE6c-7. Furthermore, MALAT1 expression level showed significant correlation with tumor size, tumor stage and depth of invasion. Kaplan-Meier analysis revealed that patients with higher MALAT1 expression had a poorer disease free survival. 24815433 Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR etc. cervical cancer tissue, cell lines (HeLa, CaSki, SiHa, HCC94 etc.) up-regulated N/A In the present study, it was identified that MALAT1 expression was upregulated in cervical cancer cell lines compared with normal cervical squamous cell samples. Further study into the effect of MALAT1 on cellular phenotype revealed that MALAT1 was able to promote cell migration and proliferation. HPV correlates with MALAT1 deregulation in cervical cancer. 24932303 Lnc2Cancer
EL0853 MALAT1 colorectal cancer qPCR etc. colorectal cancer tissue up-regulated regulation The MALAT1 levels in cancerous tissues were 2.26 times higher than those measured in noncancerous tissues, and this difference was statistically significant. Based on their expression level of MALAT1, the patients were divided into a high MALAT1 expression group and a low expression group. Patients with tumours harbouring higher expression of MALAT1 showed a significantly worse prognosis with a HR of 2.863 for DFS and 3.968 for OS. Furthermore, patients with perineural invasion demonstrated significantly worse DFS and OS than those without perineural invasion. 25031737 Lnc2Cancer
EL0853 MALAT1 laryngeal squamous cell carcinoma qPCR etc. LSCC tissue up-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
EL0853 MALAT1 multiple myeloma qPCR etc. Bone marrow up-regulated N/A MALAT1 was overexpressed in the newly diagnosed patients compared with post-treatment patients and healthy individuals. The expression of MALAT1 strongly correlated with disease status, and the magnitude of change in MALAT1 post-treatment had prognostic relevance. The patients with early progression had a significantly smaller change in MALAT1 after treatment. 25369863 LncRNADisease Lnc2Cancer
EL0853 MALAT1 pancreatic cancer qPCR etc. pancreatic cancer tissue up-regulated expression Our results indicated that lncRNA MALAT1 was highly expressed in pancreatic cancer compared with adjacent non-cancerous tissues, and positively correlated with clinical stage, tumor size, lymph node metastasis, and distant metastasis in pancreatic cancer patients. Furthermore, we also found that lncRNA MALAT1 overexpression was an unfavorable prognostic factor in pancreatic cancer patients, regardless of clinical stage, tumor size, lymph node metastasis, and distant metastasis. Finally, increased lncRNA MALAT1 expression was an independent poor prognostic factor for pancreatic patients through multivariate analysis. 25481511 Lnc2Cancer
EL0853 MALAT1 glioma qPCR etc. glioma tissue up-regulated expression LncRNA MALAT1 expression was increased in glioma tissues compared with paired adjacent brain normal tissues. Furthermore, lncRNA MALAT1 was associated significantly with WHO grade (I-II vs. III-IV; P = 0.007) and tumor size. Moreover, the level of lncRNA MALAT1 expression was markedly correlated with the glioma patients' overall survival. Multivariate analysis suggested that increased lncRNA MALAT1 expression was a poor independent prognostic predictor for glioma patients. 25613066 Lnc2Cancer
EL0853 MALAT1 gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. 26096073 Lnc2Cancer
EL0853 MALAT1 lung cancer qPCR etc. blood down-regulated expression The expression of MALAT1 in the whole blood of lung cancer patients with metastasis was stronger compared to non-metastasis, which showed that MALAT1 promotes the tumor metastasis and additionally, the whole blood with lymph node metastasis represented a lower expression of MALAT1 compared to bone or brain metastasis. 26137228 Lnc2Cancer
EL0853 MALAT1 breast cancer qPCR etc. breast cancer and adjacent non-cancerous specimens, cell lines (MDA-MB-231 and MDA-MB-453) down-regulated interaction We found that MALAT1 was downregulated in breast tumor cell lines and cancer tissue, and showed that knockdown of MALAT1 in breast cancer cell lines induced an epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3 kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer patients was associated with shorter relapse-free survival 26191181 Lnc2Cancer
EL0853 MALAT1 esophageal squamous cell carcinoma qPCR etc. ESCC tissue up-regulated expression MALAT1 expression was increased in ESCC tissue than in adjacent normal tissue samples (P< 0.001). MALAT1 level was positively related to pT stage (P= 0.01). 26406400 Lnc2Cancer
EL0853 MALAT1 renal cancer qPCR etc. clear cell renal cell carcinoma and corresponding noncancerous tissues up-regulated interaction We found that MALAT1 exist a higher fold change (Tumor/Normal) in clear cell kidney carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) Data Portal and a negative correlation with miR-200s family. We further demonstrated MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly reverse the MALAT1's stimulation on proliferation and metastasis in KIRC. In summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the progression of KIRC. 26461224 Lnc2Cancer
EL0853 MALAT1 colorectal cancer qPCR, in vitro knockdown, RIP etc. cell lines (LoVo, HCT116 ) up-regulated N/A We found that overexpression of MALAT1 could promote cell proliferation and migration in vitro, and promote tumour growth and metastasis in nude mice. In CRC, MALAT1 could bind to SFPQ, thus releasing PTBP2 from the SFPQ/PTBP2 complex. In turn, the increased SFPQ-detached PTBP2 promoted cell proliferation and migration. SFPQ critically mediated the regulatory effects of MALAT1. Moreover, in CRC tissues, MALAT1 and PTBP2 were overexpressed, both of which were associated closely with the invasion and metastasis of CRC. MALAT1 might be a potential predictor for tumour metastasis and prognosis.Furthermore, the interaction between MALAT1 and SFPQ could be a novel therapeutic target for CRC. 25025966 Lnc2Cancer
EL0853 MALAT1 endometrial stromal sarcoma qPCR, ISH etc. ESS tissue up-regulated expression MALAT-1 gene is one of the major genes upregulated in ESS. 16441420 LncRNADisease Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR, knockdown etc Tumor and adjacent normal tissues, cervical cancer cell lines(HeLa, CaSki) up-regulated expression MALAT1 expression is significantly increased in cervical cancer than in normal tissues. Its expression in the cancerous tissues is also significantly higher than in adjacent normal tissues. MALAT1 expression is correlated with tumor size, FIGO stage, vascular invasion and lymph nodes metastasis and is an independent predictor for overall survival of cervical cancer. When endogenous MALAT1 was knocked down, the cancer cells had significantly reduced proliferation and invasion and increased apoptosis 26400521 Lnc2Cancer
EL0853 MALAT1 hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue up-regulated expression Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. 21678027 LncRNADisease Lnc2Cancer
EL0853 MALAT1 urothelial carcinoma of the bladder qPCR, knockdown etc. cell lines (T24, 5737) up-regulated N/A MALAT1 was upregulated in bladder urothelial carcinoma compared with matched normal urothelium (P=.008). The MALAT1 expression levels were greater in high-grade carcinomas than in low-grade carcinoma (P=.001). The MALAT1 expression levels were greater in invasive carcinoma than in noninvasive carcinoma (P=.018). MALAT1 plays an oncogenic role in urothelial carcinoma of the bladder. 23153939 Lnc2Cancer
EL0853 MALAT1 melanoma qPCR, knockdown etc. melanoma tissue, cell line (A-375) up-regulated N/A highly expressed,can promote the metastasis of melanoma. The expression levels of UCA1 and Malat-1 lncRNAs had the potential to be prognostic indicators in metastasis of melanomas. 24892958 Lnc2Cancer
EL0853 MALAT1 gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (MKN7, MKN45, MKN74, NUGC4, AZ521, AGS, KATOIII) up-regulated interaction Expression of both lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients. Elevated HOTAIR expression emerged both as an independent prognostic and risk factor for peritoneal dissemination. SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation, migration and invasion, but concurrently enhanced the anoikis rate in transfetced cells. 25280565 Lnc2Cancer
EL0853 MALAT1 clear cell renal cell carcinoma qPCR, knockdown etc. ccRCC tissue, cell line (HK-2) up-regulated expression The expression level of MALAT1 was higher in ccRCC tissues and renal cancer cells compared to adjacent non-tumor tissues and normal human proximal tubule epithelial cells HK-2. The ccRCC patients with higher MALAT1 expression had an advanced clinical features and a shorter overall survival time than those with lower MALAT1 expression. Additionally, our data indicated that knockdown expression of MALAT1 decreased renal cancer cell proliferation, migration, and invasion. 25480417 Lnc2Cancer
EL0853 MALAT1 esophageal squamous cell carcinoma qPCR, knockdown etc. esophageal squamous cell carcinoma and adjacent nonneoplastic tissues, cell lines(TE1, KYSE30, KYSE70, KYSE150, KYSE270, KYSE410, EC9706) up-regulated expression Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase 26493997 Lnc2Cancer
EL0853 MALAT1 osteosarcoma qPCR, knockdown etc. osteosarcoma tissue, cell lines (MG63, Saos-2, hFOB1.19, MNNG/HOS) up-regulated expression We observed that MALAT1 expression was up-regulated in human osteosarcoma cell lines and tissues. In vitro knockdown of MALAT1 by siRNA significantly inhibited cell proliferation and migration, and induced cell cycle arrest and apoptosis in osteosarcoma cells. In addition, MALAT1 knockdown markedly suppressed the formation of tubular network structures and caused breakage of stress fibers in osteosarcoma cell lines U2OS and MNNG/HOS. 26575981 Lnc2Cancer
EL0853 MALAT1 non-small cell lung cancer qPCR, knockdown, Luciferase reporter assay etc. NSCLC tissue, cell lines (A549, YTLMC-9) up-regulated interaction MALAT1 is a non-coding RNA overexpressed in non-small cell lung cancer (NSCLC). TDP-43 is a ubiquitously expressed, MALAT1-binding protein implicated in cancer development. TDP-43 overexpression markedly increased MALAT1 transcript level. In summary, these findings demonstrated that MALAT1 expression by regulation of TDP-43 controls cellular growth, migration, and invasion of NSCLCs. 26265046 Lnc2Cancer
EL0853 MALAT1 esophageal squamous cell carcinoma qPCR, Luciferase reporter assay etc. ESCC tissue, cell lines (KYSE30, KYSE150, KYSE450) up-regulated regulation In this study, we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated upregulation of P21 and P27 expression and the inhibition of B-MYB expression. 25538231 Lnc2Cancer
EL0853 MALAT1 renal cell carcinoma qPCR, Luciferase reporter assay etc. RCC tissue up-regulated N/A Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. MALAT1 expression was higher in human RCC tissues, where it was associated with reduced patient survival. 25600645 LncRNADisease Lnc2Cancer
EL0853 MALAT1 multiple myeloma qPCR, Luciferase reporter assay, ELISA, knockdown etc. bone marrow up-regulated expression The expression of MALAT1 was assessed by quantitative qPCR. Consistently higher expression level of MALAT1 was found in MSCs from all 25 patient samples relative to that from healthy donors. lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoter to increase expression of LTBP3 gene. The specificity and efficiency of activation were ensured by the formation of a stable complex between MALAT1 and the LTBP3 promoter, direct interaction of MALAT1 with Sp1 and recruitment of Sp1 to the promoter. 25187517 Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR, Luciferase reporter assays, knockdown, RIP, RNA pull-down assay etc. cervical cancer tissue, cell lines (HeLa and CaSki) up-regulated interaction We found MALAT1 expression was significantly higher in radioresistant than in radiosensitive cancer cases. In addition, MALAT1 and miR-145 expression inversely changed in response to irradiation in HR-HPV+ cervical cancer cells. By using clonogenic assay and flow cytometry analysis of cell cycle distribution and apoptosis, we found CaSki and Hela cells with knockdown of MALAT1 had significantly lower colony formation, higher ratio of G2/M phase block and higher ratio of cell apoptosis. 26311052 Lnc2Cancer
EL0853 MALAT1 lung cancer qPCR, Northern blot, etc. cell lines (H1299, H1975 etc.) differential expression N/A We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells. 22491206 Lnc2Cancer
EL0853 MALAT1 fibrosarcoma qPCR, Northern blot, etc. cell line (HT1080) differential expression N/A We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells. 22491206 Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR, Northern blot, etc. cell line (HeLa) differential expression N/A We first examined the decay of MALAT-1 in various cancer cells (H1299, H1975, A549, HT1080, and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299, H1975, A549, HT1080, and HeLa TO cells were > 12, 12, 12, 12, and 9 h, respectively. MALAT-1 stabilities varied in various cancer cells. 22491206 Lnc2Cancer
EL0853 MALAT1 hepatocelluar carcinoma qPCR, Northern blot, ISH etc. HCC tissue, cell line (CT26) up-regulated expression Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest. 16878148 LncRNADisease Lnc2Cancer
EL0853 MALAT1 prostate cancer qPCR, Northern bolt etc. prostate cancer tissue, cell lines (LNCap-AD, 22Rv1, PC-3, DU145, C4-2 etc.) up-regulated N/A qPCR was used to assess the PCA3 and MALAT-1 expression levels in an additional set of 10 pairs of PCa and adjacent normal tissues. Comparing the PCA3 and MALAT-1 expression levels in the 10 paired tissue samples revealed that PCA3 and MALAT-1 were highly expressed in most of the PCa tissues. Plasma lncRNAs probably exist in the form of fragments in a stable form. MD-miniRNA enters cell culture medium at measurable levels, and MD-miniRNA derived from human PCa xenografts actually enters the circulation in vivo and can be measured to distinguish xenografted mice from controls. 23726266 Lnc2Cancer
EL0853 MALAT1 prostate cancer qPCR, RIP-Seq, knockdown, ChIP etc. cell lines (C4-2, PC-3, LNCaP) up-regulated interaction We showed that MALAT1 enhances expression of PRC2-independent target genes of EZH2 in CRPC cells in culture and patient-derived xenografts. Together, these data indicate that MALAT1 may be a crucial RNA cofactor of EZH2 and that the EZH2-MALAT1 association may provide a new avenue for development new strategies for treatment of CRPC. 26516927 Lnc2Cancer
EL0853 MALAT1 gallbladder cancer qPCR, Western blot etc. GBC tissue, cell lines (SGC-996, NOZ) up-regulated regulation MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. 24658096 LncRNADisease Lnc2Cancer
EL0853 MALAT1 non-small cell lung cancer qPCR, Western blot etc. NSCLC tissue, cell lines (H1915) up-regulated expression We observed that the level of MALAT1 was significantly higher in brain metastasis than that of non brain metastasis samples. The level of MALAT1 was associated with patients' survival. We found that MALAT1 is increased in highly invasive subline of brain metastasis lung cancer cells. Further functional studies indicate that silencing MALAT1 inhibits highly invasive subline of brain metastasis lung cancer cell migration and metastasis by inducing epithelial-mesenchymal transition (EMT). 25217850 Lnc2Cancer
EL0853 MALAT1 pancreatic cancer qPCR, Western blot etc. cell lines (AsPC-1, CFPAC-1) up-regulated expression In this study, our data showed that MALAT-1 could increase the proportion of pancreatic CSCs, maintain self-renewing capacity, decrease the chemosensitivity to anticancer drugs, and accelerate tumor angiogenesis in vitro. In addition, subcutaneous nude mouse xenografts revealed that MALAT-1 could promote tumorigenicity of pancreatic cancer cells in vivo. The underlying mechanisms may involve in increased expression of self-renewal related factors Sox2. 25811929 Lnc2Cancer
EL0853 MALAT1 pancreatic cancer qPCR, Western blot, FCA etc. pancreatic cancer tissue, cell lines (BxPC-3, CFPAC-1, CAPAN-1, SW1990 etc.) up-regulated expression In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. 25269958 Lnc2Cancer
EL0853 MALAT1 gastric cancer qPCR, Western blot, knockdown etc. cell lines (SGC-7901, MKN-45, SUN-16) up-regulated N/A In this study, we found that MALAT1 was aberrantly highly expressed in GC cell lines (SGC-7901, MKN-45 and SUN-16), and induced specific distribution and over-expression of SF2/ASF in nucleolus. Knock-down of MALAT1 or SF2/ASF in SGC-7901 cells respectively induced significant arrest of cell cycle in G0/G1 phase along with a remarkable suppression of cell proliferation, and the nuclear distribution and expression of SF2/ASF was significantly impaired when MALAT1 was depleted. However, over-expression of SF2/ASF exhibited no effect on rescuing the cell proliferation suppression by MALAT1 depletion. 24857172 Lnc2Cancer
EL0853 MALAT1 osteosarcoma qPCR, Western blot, knockdown etc. osteosarcoma tissue, cell lines (SAOS2, MG63, U2OS) up-regulated expression In our research, the MALAT1 messenger RNA (mRNA) was highly expressed in human osteosarcoma tissues, and its expression level was closely correlated with pulmonary metastasis. Knockdown of MALAT1 inhibited the proliferation and invasion of human osteosarcoma cell and suppressed its metastasis in vitro and vivo. MALAT1 might suppress the tumor growth and metastasis via PI3K/AKT signaling pathway. 25431257 Lnc2Cancer
EL0853 MALAT1 esophageal squamous cell carcinoma qPCR, Western blot, knockdown etc. ESCC tissue, cell lines (EC109, EC9706, KYSE150, KYSE450) up-regulated expression MALAT1 was over-expressed in 46.3% of ESCC tissues, mostly in the high-stage tumor samples. Enhanced MALAT1 expression levels were positively correlated with clinical stages, primary tumor size, and lymph node metastasis. Inhibition of MALAT1 suppressed tumor proliferation in vitro and in vivo, as well as the migratory and invasive capacity.MALAT1 serves as an oncogene in ESCC, and it regulates ESCC growth by modifying the ATM-CHK2 pathway. 25613496 Lnc2Cancer
EL0853 MALAT1 oral squamous cell carcinoma qPCR, Western blot, knockdown etc. OSCC tissue, cell lines (Tscca, Tca8113P160, Tca8113, Hep-2) up-regulated interaction We found that MALAT1 is overexpressed in OSCC tissues compared to normal oral mucosa by real-time PCR. MALAT1 served as a new prognostic factor in OSCC patients. When knockdown by small interfering RNA (siRNA) in OSCC cell lines TSCCA and Tca8113, MALAT1 was shown to be required for maintaining epithelial-mesenchymal transition (EMT) mediated cell migration and invasion. Western blot and immunofluorescence staining showed that MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro. Meanwhile, both nucleus and cytoplasm levels of β-catenin and NF-B were attenuated, while elevated MALAT1 level triggered the expression of β-catenin and NF-B. More importantly, targeting MALAT1 inhibited TSCCA cell-induced xenograft tumor growth in vivo. 26522444 Lnc2Cancer
EL0853 MALAT1 cervical cancer qPCR, Western blot, Luciferase reporter assay, knockdown, FCA etc. HR-HPV+ cervical cancer tisssue, cell lines (HeLa, CaSki, SiHa) up-regulated interaction Findings of this study confirmed higher MALAT1 expression in HR-HPV (+) cervical cancer. Knockdown of endogenous MALAT1 significantly reduced cell growth rate and invasion and increased cell apoptosis of Hela and siHa cells. Besides, knockdown of MALAT1 increased the expression of miRNA-124, while ectopic expression of miR-124 decreased MALAT1 expression. MALAT1 can indirectly modulate GRB2 expression via competing miR-124. Knockdown of GRB2 reduced cell invasion and increased cell apoptosis. In conclusion, MALAT1 can promote HR-HPV (+) cancer cell growth and invasion at least partially through the MALAT1-miR-124-RBG2 axis. 26242259 Lnc2Cancer
EL0853 MALAT1 colorectal cancer qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. CRC tissue, cell lines (LoVo etc.) up-regulated N/A Using in situ hybridization, we found there was higher expression of MALAT1 in the CRC than the adjacent normal colorectal tissue. We next conducted correlation analysis between MALAT1 expression and clinicopathological characteristics of CRC. A statistically significant association was observed between MALAT1 expression and extent of metastasis and invasion. In contrast to adjacent normal tissues, the MALAT1 expression in CRC tissues resected from patients with metastatic diseases was higher than those with no metastasis. 24244343 Lnc2Cancer
EL0853 MALAT1 bladder cancer qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. bladder cancer tissue, cell lines (T24, RT4 etc.) up-regulated N/A TGFβ1 induces malat1 expression and EMT in bladder cancer cells. malat1 overexpression is significantly correlated with poor survival in patients with bladder cancer. malat1 and E-cadherin expression is negatively correlated in vitro and in vivo. malat1 knockdown inhibits TGFβ1 induced EMT. malat1 is associated with suz12, and this association results in decrease of E-cadherin expression and increase of N-cadherin and fibronectin expression. Targeted inhibition of malat1 or suz12 suppresses the migratory and invasive properties induced by TGFβ1 We demonstrated that malat1 or suz12 knockdown inhibits tumor metastasis in animal models. 24449823 Lnc2Cancer
EL0853 MALAT1 breast cancer qPCR, Western blot, Luciferase reporter assays etc. breast cancer patients tissues down-regulated interaction The effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells 26275461 Lnc2Cancer
EL0853 MALAT1 nasopharyngeal carcinoma qPCR, Western blot, Luciferase reporter assays, RIP etc. NPC cell lines (5-8F, CNE-2, HONE-1, SUNE-1), NPE cell line (NP-69) up-regulated interaction We found that MALAT1 regulated radioresistance by modulating cancer stem cell (CSC) activity. Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. Taking these observations into consideration, we proposed that MALAT1 regulated CSC activity and radioresistance by modulating miR-1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients 26482776 Lnc2Cancer
EL0853 MALAT1 breast cancer qPCR, Western blot, Luciferase reporter assays, RIP etc. breast cancer specimens and adjacent normal breast tissue up-regulated interaction We reported that MALAT1 was upregulated in triple-negative breast cancer (TNBC) tissues. Knockdown of MALAT1 inhibited proliferation, motility, and increased apoptosis in vitro. In vivo study indicated that knockdown of MALAT1 inhibited tumor growth and metastasis. Patients with high MALAT1 expression had poorer overall survival time than those with low MALAT1 expression. In addition, our findings demonstrate a reciprocal negative control relationship between MALAT1 and miR-1: downregulation of MALAT1 increased expression of microRNA-1 (miR-1), while overexpression of miR-1 decreased MALAT1 expression. Slug was identified as a direct target of miR-1. 26676637 Lnc2Cancer
EL0853 MALAT1 glioma qPCR, Western blot, Luciferase reporter assays, RIP, ChIP etc. glioma samples and normal brain tissues, cell lines (hCMEC/D3, ECs) up-regulated interaction Our results proved that MALAT1 expression was up-regulated in brain microvessels of human glioma and glioma endothelial cells (GECs) which were obtained by co-culturing endothelial cells with glioma cells. Functionally, knockdown of MALAT1 resulted in an impairment and increased the permeability of BTB as well as decreased the expression of ZO-1, occludin and claudin-5 in GECs. Further, there was reciprocal repression between MALAT1 and miR-140, and miR-140 mediated the effects that MALAT1 knockdown exerted. Mechanistic investigations defined that nuclear factor YA (NFYA), a CCAAT box-binding transcription factor, was a direct and functional downstream target of miR-140, which was involved in the MALAT1 knockdown induced regulation of BTB function. Furthermore, NFYA could up-regulate the promoter activities and bind to the promoters of ZO-1, occludin and claudin-5 in GECs. 26619802 Lnc2Cancer
EL0853 MALAT1 breast cancer qPCR, Western blot, Northern blot, knockdown etc. cell lines (MB231, MCF7 etc.) up-regulated N/A Specifically, we looked for the changes of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1), which is found extensively and highly expressed in several kinds of tumor cells, including breast carcinoma. It was observed that proliferation, migration and invasion of breast cells were greatly affected by high concentration E2 treatment and were not affected by low concentration E2 treatment in an ERa independent way. We found that the high concentration E2 treatment largely decreased MALAT-1 RNA level. Interestingly, MALAT-1 decreasing by knocking down showed similar effects on proliferation, migration and invasion. 24525122 Lnc2Cancer
EL0853 MALAT1 nasopharyngeal carcinoma qPCR, Western bolt etc. cell lines (5-8F, 6-10B, CNE-1, CNE-2 etc.) up-regulated N/A MALAT1 was highly expressed in 5-8F cells with a high metastatic potential, and lowly expressed in normal nasopharyngeal epithelium cells. Overexpression of MALAT1 by RNAa suppressed the expression of E-cadherin, promoted the expression of vimentin and enhanced the proliferation, invasion, and metastasis of CNE-1 cells. 23688988 Lnc2Cancer
EL0853 MALAT1 bladder cancer qPCR, Western bolt, Luciferase reporter assay etc. bladder cancer tissue, cell line (T24) up-regulated N/A We verified that MALAT-1 levels were upregulated in bladder cancer tissues compared with adjacent normal tissues, and MALAT-1 expression was remarkably increased in primary tumors that subsequently metastasized, when compared to those primary tumors that did not metastasize. levels. We further demonstrated that MALAT-1 promoted EMT by activating Wnt signaling in vitro. 22722759 Lnc2Cancer
EL0853 MALAT1 esophageal squamous cell carcinoma qRT-PCR 106 paired ESCC tissues down-regulated N/A MALAT1 decreased tumor formation and improved survival 27015363
EL0853 MALAT1 gastric cancer RNA immunoprecipitation RIP-seq gastric cancer cell lines N/A N/A suppresses the tumor suppressor PCDH10 and promotes gastric cellular migration and invasion 26871474
EL0853 MALAT1 prostate cancer RNA-seq, qPCR etc. prostate cancer tissue up-regulated N/A Consistent with the RNA-seq results, PCA3, FR0348383 and MALAT1 overexpression was found in 80% (32/40), 72.5% (29/40), and 82.5% (33/40) of the prostate cancers respectively, whereas decreased FR0257520 expression was found in 82.5% (33/40) of the prostate cancers. 22349460 Lnc2Cancer
EL0853 MALAT1 pre-eclampsia short interfering RNA (siRNA) placentas from the patients with preeclampsia, EG-3 trophoblast cell line down-regulated interaction Silencing of MALAT-1 in JEG-3 cells suppressed proliferation and induced cell cycle arrest at G0/G1 phase. The migration rate and the invasiveness of JEG-3 cells were suppressed when MALAT-1 was downregulated. MALAT-1 may play an important role in the regulation of proliferation, cell cycle, apoptosis, migration and invasion of trophoblast cells, and under-expression of MALAT-1 during early placentation may be involved in the pathogenesis of preeclampsia. 26722461
EL0853 MALAT1 triple-negative breast cancer tissue microarray; immunoblotting, polymerase chain reaction, loss and gain of gene MDA-MB-231 cells up-regulated N/A N/A 26917489
EL0854 Malat1 hereditary degenerative disease myotonic dystrophy type 1 knockdown a transgenic mouse model of DM1 N/A expression Systemically administered ASOs were also effective for muscle knockdown of Malat1, a long non-coding RNA (lncRNA) that is retained in the nucleus. 22859208
EL0854 Malat1 mammary carcinoma knockdown MMTV (mouse mammary tumor virus)-PyMT mouse mammary carcinoma model N/A expression Malat1 loss results in a reduction of branching morphogenesis in MMTV-PyMT- and Her2/neu-amplified tumor organoids, increased cell adhesion, and loss of migration. 26701265
EL0854 Malat1 Flavivirus infection N/A N/A N/A expression Activation of Malat1 following infection by two flaviviruses, both of which activate the UPR in host cells. 26634309
EL0855 MALAT2 gastric cancer qPCR, Western blot etc. gastric cancer tissue up-regulated N/A MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. MALAT2 was frequently over-expressed in cancer tissues and this over-expression was found to significantly correlate with lymph node metastasis and tumor stage. 25721209 LncRNADisease Lnc2Cancer
EL0856 MAP3K14 pancreatic ductal adenocarcinoma microarray, qPCR etc. cell line (MIA PaCa-2 ) up-regulated expression Differential expression 22078386 LncRNADisease Lnc2Cancer
EL0859 MDC1-AS1 bladder cancer microarray, qPCR etc. bladder cancer tissue down-regulated interaction The expression levels of MDC1-AS and MDC1 was down-regulated in bladder cancer. After over-expression of MDC1-AS, increased levels of MDC1 were observed in bladder cancer cells. We also found a remarkably inhibitory role of antisense lncRNA MDC1-AS on malignant cell behaviors in bladder cancer cells EJ and T24. 25514464 Lnc2Cancer
EL0861 MEG3 pancreatic cancer genome-wide LncRNA microarray analysis pancreatic cancer cell lines down-regulated N/A overexpression of MEG3 induced cells death and increased p53 expression 26850851
EL0861 MEG3 non-functioning pituitary adenoma inducible and constitutively active expression systems PDFS cells derived from a human NFA (non-functioning pituitary adenomas) up-regulated expression MEG3 expression significantly suppressed xenograft tumor growth in vivo in nude mice. When induced in culture, MEG3 caused cell cycle arrest at the G1 phase. 26284494
EL0861 MEG3 multiple myeloma knockdown, overexpression, ChIP, RIP bone marrow mesenchymal stromal cells (MSCs) down-regulated expression Our data provided novel evidence for the biological and clinical significance of lncRNA MEG3 expression as a potential biomarker for identifying patients with MM and as a potential therapeutic target in MM. 25753650
EL0861 MEG3 hepatocellular carcinoma methylation specific PCR (MSP), qRT-PCR, RNA pulldown and western blot analysis, MTT assay, fluorescence microscopy and flow cytometry, improved MS2 biotin tagged RNA affinity purification method hepatoma HepG2 and Huh7 cells up-regulated interaction Ectopic expression of MEG3 inhibited hepatoma cell growth in a time-dependent manner, resulted in cell cycle arrest and induced apoptosis. Adenosine increases MEG3 expression by inhibition of DNA methylation and its antitumor effects is involved in MEG3 activation. 26647875
EL0861 MEG3 tongue squamous cell carcinoma microarray, MSP, Western blot, knockdown etc. TSCC tissue, cell lines (SCC-15, CAL27 etc.) down-regulated N/A We report here that miR-26a and lncRNA MEG3 gene expression were both strongly reduced in TSCC compared with levels in matched nonmalignant tissues, and combined low expression levels of both miR-26a and MEG3 emerged as an independent prognostic factor for poor clinical outcome in TSCC patients. 24343426 Lnc2Cancer
EL0861 MEG3 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated expression Enforced expression of MEG3 in HCC cells significantly decreased both anchorage-dependent and -independent cell growth, and induced apoptosis. Methylation-dependent tissue-specific regulation of the lncRNA MEG3 by miR-29a may contribute to HCC growth. 21625215 LncRNADisease Lnc2Cancer
EL0861 MEG3 non-functioning pituitary adenoma microarray, qPCR etc. NFPA tissue down-regulated N/A qPCR analyses showed that MEG3 expression was lost in 32 of 52 NFPAs (61.5 %). In addition, MEG3 lncRNA levels were significantly decreased in invasive NFPAs and non-invasive NFPAs compared to normal anterior pituitaries. Furthermore, MEG3 expression was significantly decreased in invasive NFPAs compared to non-invasive NFPAs. 24469926 LncRNADisease Lnc2Cancer
EL0861 MEG3 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated interaction Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion.Thus, this study suggests that MEG3 acts as novel suppressor of migration and invasion by targeting Rac1 gene. 25997963 Lnc2Cancer
EL0861 MEG3 lung adenocarcinoma microarray, qPCR, Western blot etc. lung cancer tissue, cell lines (A549 etc.) down-regulated interaction MEG3 expression was markedly decreased in cisplatin-resistant A549/DDP cells compared with parental A549 cells as shown by an lncRNA microarray. MEG3 overexpression in A549/DDP cells increased their chemosensitivity to cisplatin both in vitro and in vivo by inhibiting cell proliferation and inducing apoptosis. Moreover, MEG3 was decreased in cisplatin-insensitive LAD tissues while p53 protein levels were decreased and Bcl-xl protein levels increased. 25992654 Lnc2Cancer
EL0861 MEG3 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0861 MEG3 acute myeloid leukemia MSP etc. bone marrow down-regulated epigenetics MEG3 hypermethylation occurred in 15 MDS patients (34.9%), and in 20 AML patients (47.6%). 19595458 LncRNADisease Lnc2Cancer
EL0861 MEG3 glioma N/A gliomas tissues down-regulated epigenetics The downregulation of MEG3 expression due to hypermethylation of MEG3 was observed in gliomas tissues. Treatment of glioma cells with the DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-AzadC) decreased aberrant hypermethylation of the MEG3 promoter and prevented the loss of MEG3 expression. 26676363
EL0861 MEG3 hepatocelluar carcinoma N/A MS2 virus-like particles (VLPs) crosslinked with GE11 polypeptide N/A N/A N/A 26992211
EL0861 MEG3 myelodysplastic syndrome N/A N/A N/A epigenetics MEG3 hypermethylation occurred in 15 MDS patients (34.9%), and in 20 AML patients (47.6%). 19595458 LncRNADisease Lnc2Cancer
EL0861 MEG3 type 1 diabetes mellitus N/A N/A N/A locus The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. 19966805 LncRNADisease
EL0861 MEG3 heroin abuse N/A N/A N/A mutation Intriguingly a genome-wide association study has implicated MEG3 in the vulnerability to heroin addiction. 21128942 LncRNADisease
EL0861 MEG3 cancer N/A N/A N/A N/A MEG3 could represent a tumor suppressor gene located in chromosome 14q32 and its association with tumorigenesis is growing every day. 21400503 LncRNADisease
EL0861 MEG3 cancer N/A N/A N/A N/A MEG3 functions as a novel lncRNA tumor suppressor. 22393162 LncRNADisease
EL0861 MEG3 meningioma N/A N/A N/A regulation MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. 23307326 LncRNADisease
EL0861 MEG3 Huntington's disease N/A N/A N/A expression LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD. 23346095 LncRNADisease
EL0861 MEG3 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL0861 MEG3 hepatocelluar carcinoma N/A N/A N/A expression Braconi et al. found that the expression of maternally expressed gene 3 (MEG3) is markedly reduced in four human HCC cell lines compared with normal hepatocytes and enforced expression of MEG3 in HCC cells significantly induce apoptosis. 24296588 LncRNADisease
EL0861 MEG3 bladder cancer N/A N/A N/A regulation Tumour suppressor 24373479 LncRNADisease
EL0861 MEG3 kidney cancer N/A N/A N/A expression Tumour suppressor 24373479 LncRNADisease
EL0861 MEG3 hepatocelluar carcinoma N/A N/A N/A regulation Expression of MEG3 in tumor cells results in growth suppression, p53 protein increase, and activation of p53 downstream targets. 24757675 LncRNADisease
EL0861 MEG3 pituitary adenoma N/A N/A N/A expression Another potential angiogenic lncRNA, Maternally expressed gene 3 (MEG3) was found to be silenced in pituitary adenomas.? 24829860 LncRNADisease
EL0861 MEG3 pancreatic neuroendocrine tumors overexpression, microarray pancreatic neuroendocrine tumors (PNETs) cells N/A epigenetics The epigenetic activation of lncRNA MEG3 and/or inactivation of c-MET could be therapeutic for treating PNETs and insulinomas. 25565142
EL0861 MEG3 non-functioning pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated epigenetics Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. 15644399 LncRNADisease Lnc2Cancer
EL0861 MEG3 phaeochromocytoma qPCR etc. phaeochromocytoma tissue down-regulated N/A Hypermethylation of the GTL2 promoter DMR was detected in 25% of neuroblastomas, 10% of phaeochromocytoma and 2.5% of Wilms' tumours. Tumours with GTL2 promoter DMR hypermethylation also demonstrated hypermethylation at an upstream intergenic DMR thought to represent a germline imprinting control element. 15798773 LncRNADisease Lnc2Cancer
EL0861 MEG3 Wilms' tumor qPCR etc. Wilms' tumor tissue down-regulated N/A Hypermethylation of the GTL2 promoter DMR was detected in 25% of neuroblastomas, 10% of phaeochromocytoma and 2.5% of Wilms' tumours. Tumours with GTL2 promoter DMR hypermethylation also demonstrated hypermethylation at an upstream intergenic DMR thought to represent a germline imprinting control element. 15798773 LncRNADisease Lnc2Cancer
EL0861 MEG3 neuroblastoma qPCR etc. neuroblastoma tissue down-regulated epigenetics MEG3-DMR is completely methylated in neuroblastoma cell lines. 15798773 LncRNADisease Lnc2Cancer
EL0861 MEG3 non-functioning pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated expression Maternally Expressed Gene 3 (MEG3), which is specifically associated with clinically non-functioning pituitary adenomas of a gonadotroph lineage. 20211686 LncRNADisease Lnc2Cancer
EL0861 MEG3 pituitary adenoma qPCR etc. pituitary tumor tissue down-regulated N/A In summary, MEG3 and GADD45γ expression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. 21850407 Lnc2Cancer
EL0861 MEG3 non-functioning pituitary adenoma qPCR etc. pituitary adenoma tissue down-regulated expression The DLK1-MEG3 locus is silenced in NFAs (nonfunctioning adenomas). The DLK1-MEG3 locus plays a tumor suppressor role in human NFAs. 21871428 LncRNADisease Lnc2Cancer
EL0861 MEG3 cervical cancer qPCR etc. cell line (CaSki) up-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL0861 MEG3 oral squamous cell carcinoma qPCR etc. OSCC tissues down-regulated N/A We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. 23292713 Lnc2Cancer
EL0861 MEG3 pituitary adenoma qPCR etc. pituitary adenomas tissue up-regulated N/A MEG3 lncRNA levels gradually decreased whereas HOTAIR lncRNA levels gradually increased from normal anterior pituitaries to non-invasive NFPAs to invasive NFPAs. There was a significant association between MEG3 (P < 0.01) and HOTAIR (P < 0.05) expression and the biological behavior of the tumor. Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to non-invasive ones (P < 0.01). In addition, PCNA mRNA negatively correlated with MEG3 lncRNA levels 24469926 LncRNADisease Lnc2Cancer
EL0861 MEG3 glioma qPCR etc. cell lines(U251, U87) up-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
EL0861 MEG3 cervical cancer qPCR, ISH etc. cervical cancer tissue down-regulated N/A A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 pituitary adenoma qPCR, ISH etc. pituitary tumor tissue down-regulated N/A Therefore, RT-PCR was used to detect specific MEG3a isoform expression in different human pituitary tumor phenotypes. Figure 4B shows that there was no MEG3a expression in three GH-secreting tumors and eight clinically nonfunctioning pituitary tumors, in contrast to the five normal human pituitaries. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 prostate cancer qPCR, ISH etc. prostate cancer tissue down-regulated N/A MEG3 mRNA is expressed in the normal human fibroblast cells but is undetectable in human cancer cell lines by Northern blot. Lanes 110, Human carcinoma cells HeLa, MCF-7, T47-D, T24, 5637, Du145, K562, HT29, H1299, H4; lanes 11 and 12, human normal fibroblasts HS-27 and WI38. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 breast cancer qPCR, ISH etc. bladder cancer tissue down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 bladder cancer qPCR, ISH etc. breast cancer tissue down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 colon cancer qPCR, ISH etc. colon cancer tissue down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 glioma qPCR, ISH etc. neuroglioma tissue down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 lung cancer qPCR, ISH etc. lung cancer tissue down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 chronic myeloid leukemia qPCR, ISH etc. blood down-regulated expression MEG3 expression is lost. 14602737 LncRNADisease Lnc2Cancer
EL0861 MEG3 non-functioning pituitary adenoma qPCR, ISH etc. pituitary tumor tissue down-regulated epigenetics Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. 18628527 LncRNADisease Lnc2Cancer
EL0861 MEG3 glioma qPCR, Luciferase reporter assay etc. cell lines (U251, U87 etc.) down-regulated expression Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. 22234798 LncRNADisease Lnc2Cancer
EL0861 MEG3 meningioma qPCR, Luciferase reporter assay, ISH etc. meningioma tissue down-regulated epigenetics Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. 20179190 LncRNADisease Lnc2Cancer
EL0861 MEG3 gastric cancer qPCR, Luciferase reporter assay, RNA pull-down assay etc. gastric cancer tissue, cell lines (MGC-803, HGC-27, MKN-45, SGC-7901, BGC-823, AGS) down-regulated interaction MEG3 is decreased in GC patients and cell lines, and its expression was associated with metastatic GC. Furthermore, ectopic expression of MEG3 in HGC-27 and MGC-803 cells inhibited cell proliferation, migration, invasion, and promoted cell apoptosis, which might be due to MEG3 sequestering oncogenic miR-181 s in GC cells. Furthermore, MEG3 could up-regulated Bcl-2 via its competing endogenous RNA (ceRNA) activity on miR-181a. 26253106 Lnc2Cancer
EL0861 MEG3 epithelial ovarian cancer qPCR, MSP, Western blot, Luciferase reporter assay etc. epithelial ovarian cancer tissue, cell lines (OVCAR3, SKOV3, HP8910, ES-2) down-regulated N/A In contrast to normal ovarian tissues, the expression of MEG3 was absent or decreased in most EOC tissues as well as in human EOC cell lines, and the promoter of the MEG3 gene was highly methylated in both cancer tissues and cell lines. In addition, ectopic expression of MEG3 suppressed the proliferation and growth of OVCAR3 cells and promoted apoptosis. Finally, MEG3 activated p53 in OVCAR3 cells. 24859196 Lnc2Cancer
EL0861 MEG3 bladder cancer qPCR, Western blot etc. bladder cancer tissue, cell line (T24) down-regulated regulation Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. 23295831 LncRNADisease Lnc2Cancer
EL0861 MEG3 non-small cell lung cancer qPCR, Western blot etc. NSCLC tissue, cell lines (A549, SPC-A1,NCI-H1650, NCI-H358, NCI-H1299, NCI-H1975 etc.) down-regulated N/A MEG3 is significantly down-regulated in NSCLC tissues that could be affected by DNA methylation. Overexpression of MEG3 decreased NSCLC cells proliferation and induced apoptosis.Partially via the activition of p53. Thus, MEG3 may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention. 24098911 Lnc2Cancer
EL0861 MEG3 gastric cancer qPCR, Western blot etc. gastric cancer tissue, cell line (GES-1) down-regulated interaction We found that expression of both miR-141 and MEG3 was significantly reduced in GC compared with levels in matched nonmalignant tissues. Positive correlation between miR-141 and MEG3 was found in both tumor tissues and control tissues. Furthermore, the over-expression of either miR-141 or MEG3 in 7901 and MKN45 cells inhibited cell proliferation and cell cycle progression and promoted cell apoptosis. E2F3 was identified as a target of miR-141, and its inhibition significantly reduced MEG3 expression. E2F3 over-expression partly reversed the changes caused by transfection of miR-141 mimic, and inhibition of miR-141 or MEG3 overrides MEG3- or miR-141-induced modulation of cell growth in GC. 26233544 Lnc2Cancer
EL0861 MEG3 colorectal cancer qPCR, Western blot, FCA etc. CRC tissue down-regulated expression The lower expression of MEG3 was remarkably correlated with low histological grade, deep tumor invasion, and advanced tumor node metastasis (TNM) stage. Multivariate analyses revealed that MEG3 expression served as an independent predictor for overall survival. Further experiments revealed that overexpressed MEG3 significantly inhibited CRC cell proliferation both in vitro and in vivo. MEG3 is involved in the development and progression of colorectal cancer by regulating cell proliferation and shows that MEG3 may be a potential diagnostic and prognostic target in patients with colorectal cancer. 25636452 Lnc2Cancer
EL0861 MEG3 clear cell renal cell carcinoma qPCR, Western blot, FCA etc. ccRCC tissue, cell lines (786-0, SN1) down-regulated interaction The results showed that MEG3 was downregulated in RCC tissues and RCC cell lines. Overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm. Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression. It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. 26223924 Lnc2Cancer
EL0861 MEG3 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC-7901, BGC-823, GES-1 etc.) down-regulated N/A We examined the expression of MEG3 in 52 gastric cancer samples using quantitative qPCR and found the down-regulation of MEG3 in both gastric cancer tissues and cell lines. The positive correlation of MEG3 and miR-148a was further confirmed in SGC-7901 and BGC-823 gastric cancer cell lines. Hypermethylation of MEG3 differentially methylated regions was identified by methylation-specific PCR, and MEG3 expression was increased with the inhibition of methylation with siRNA to DNMT-1 in gastric cancer cells. In addition, transfection of MEG3 siRNA into gastric cancer cells diminished the suppression of proliferation induced by overexpression of miR-148a. 24515776 Lnc2Cancer
EL0861 MEG3 cervical cancer qPCR, Western blot, knockdown etc. cervical cancer, cell lines (HeLa, CaSki) down-regulated interaction We observed that MEG3 was downregulated in cervical cancer tissues, compared to the adjacent normal tissues, and was negatively related with FIGO stages, tumor size, lymphatic metastasis, HR-HPV infection and the expression of homo sapiens microRNA-21 (miR-21). Furthermore, we focused on the function and molecular mechanism of MEG3, finding that overexpression of MEG3 reduced the level of miR-21-5p expression, causing inhibition of proliferation and increased apoptosis in cervical cancer cells. In summary, our findings indicate that MEG3 function as a tumor suppressor by regulating miR-21-5p, resulting in the inhibition of tumor growth in cervical cancer. 26574780 Lnc2Cancer
EL0861 MEG3 prostate cancer qPCR, Western blot, knockdown, Flow cytometry assay etc. prostate cancer tissue, cell lines (PC3, Du145) down-regulated interaction MEG3 decreased significantly in prostate cancer tissues relative to adjacent normal tissues. MEG3 inhibited intrinsic cell survival pathway in vitro and in vivo by reducing the protein expression of Bcl-2, enhancing Bax and activating caspase 3. We further demonstrated that MEG3 inhibited the expression of cell cycle regulatory protein Cyclin D1 and induced cell cycle arrest in G0/G1 phase. 26610246 Lnc2Cancer
EL0861 MEG3 cervical cancer qPCR, Western bolt etc. cervical cancer tissue, cell lines (HeLa, C-33A, HCC94 etc.) down-regulated N/A qPCR results showed high expression levels of MEG3 in non-neoplastic tissues, but markedly lower levels in cancer tissues. Ectopic expression of MEG3 inhibited the proliferation of human cervical carcinoma cells HeLa and C-33A in vitro. On the other hand, knockdown of MEG3 promoted the growth of well-differentiated cervical carcinoma HCC94 cells. Further investigation into the mechanisms responsible for the growth inhibitory effects revealed that overexpression of MEG3 resulted in the induction of G2/M cell cycle arrest and apoptosis. 23790166 Lnc2Cancer
EL0861 MEG3 gastric cancer qPCR, Western bolt, knockdown etc. gastric cancer tissue, cell lines (SGC7901, AGS, MGC803, MKN45, BGC823 etc.) down-regulated expression Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. 24006224 LncRNADisease Lnc2Cancer
EL0861 MEG3 osteosarcoma quantitative real-time PCR (qRT-PCR) osteosarcoma tissues down-regulated expression The expression of lncRNA MEG3 was associated with clinical stage and istant metastasis (P<0.05). Kaplan-Meier analysis showed that patients with low lncRNA MEG3 expression had a shorter overall survival (log-rank test, P<0.05). Furthermore, multivariate analysis revealed that decreased expression of lncRNA MEG3, advanced clinical stage and distant metastasis were all independent predictors to overall survival of osteosarcoma patients. Downregulation of lncRNA MEG3 was associated with poor overall survival of osteosarcoma. LncRNA MEG3 could be a useful biomarker for progression and prognosis of osteosarcoma. 26823857
EL0861 MEG3 type 2 diabetes mellitus real-time PCR, western blotting High-fat diet mice, ob/ob mice and mice primary hepatocytes up-regulated interaction MEG3 interference could reverse the up-regulation of triglyceride as well as impaired glucose tolerance and down-regulation of glucogen content in high-fat diet mice or ob/ob mice. Upregulation of lncRNA MEG3 enhances hepatic insulin resistance via increasing foxO1 expression, suggesting that MEG3 may be a potential target and therapeutic strategy for diabetes. 26603935
EL0861 MEG3 osteoarthritis RT-PCR articular cartilage samples from 20 Osteoarthritis (OA) patients down-regulated expression Maternally expressed gene 3 (MEG3) is a maternally expressed lncRNA and may function as a tumor suppressor by inhibiting angiogenesis. The results show that human MEG3 is significantly downregulated in OA patients compared to normal cartilage samples. MEG3 may be involved in OA development through the regulation of angiogenesis。 26090403
EL0862 Meg3 diabetes mellitus MEG3 knockdown STZ-induced diabetic mice N/A N/A knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro 26845358
EL0862 Meg3 non-functioning pituitary adenoma Quantitative RT-PCR immunohistological Meg3 knockout mice up-regulated expression Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis 20392836
EL0864 MESTIT1 Silver-Russell syndrome N/A N/A N/A N/A Association 12746419 LncRNADisease
EL0867 MHRT acute myocardial infarction knockdown the blood from acute myocardial infarction (AMI) patients, neonatal rat cardiac myocytes injury induced by H2O2 up-regulated expression Knockdown of MHRT led to significant more apoptotic cells than the non-target control ((**) p<0.01), indicating that the lncRNA MHRT is a protective factor for cardiomyocyte and the plasma concentration of MHRT may serve as a biomarker for myocardial infarction diagnosis in humans AMI. 26759697
EL0868 Mhrt heart hypertrophy Northern blot and in situ Hybridization,ChIP–qPCR N/A N/A interaction Pathological stress activates the Brg1-Hdac-Parp chromatin repressor complex to inhibit Mhrt transcription in the heart. Such stress-induced Mhrt repression is essential for cardiomyopathy to develop. 25119045
EL0869 MIAT myocardial infarction N/A N/A N/A mutation In vitro functional analyses revealed that the minor variant of one SNP in exon 5 increased transcriptional level of MIAT. Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI. 17066261 LncRNADisease
EL0869 MIAT myocardial infarction N/A N/A N/A mutation SNPs associated with myocardial infarction localized to a haplotype block that encompassed the last 3 exons of MIAT. 20951849 LncRNADisease
EL0869 MIAT drug abuse N/A N/A N/A expression MIAT turned out to be one of the top twenty-five, of nearly 39,000, transcripts differentially expressed in the nucleus accumbens,a midbrain region pivotal in drug abuse, in a case-control study of human heroin and cocaine abusers. 20951849 LncRNADisease
EL0869 MIAT heroin abuse N/A N/A N/A expression The lncRNA MIAT is upregulated in heroin abusers. 21128942 LncRNADisease
EL0869 MIAT myocardial infarction N/A N/A N/A mutation MIAT lincRNA Variants Confer Susceptibility to Myocardial Infarction 23104877 LncRNADisease
EL0869 MIAT schizophrenia N/A N/A N/A expression Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. 23628989 LncRNADisease
EL0869 MIAT myocardial infarction N/A N/A N/A regulation A myocardial infarction-associated transcript (MIAT), also known as RNCR2 or Gomafu, is a long intergenic non-coding RNA that presents many genetic variants implicated in different processes. A large scale case-control association study regarding cardiovascular disease demonstrates that a MIAT variant (rs2301523) confers susceptibility to myocardial infarction. 24113581 LncRNADisease
EL0869 MIAT cancer N/A N/A N/A regulation Another lncRNA serving as oncogene is retinal noncoding RNA 2 (RNCR2). 24757675 LncRNADisease
EL0869 MIAT acute myocardial infarction N/A N/A N/A N/A Patients with ST-segment-elevation MI had lower levels of myocardial infarction-associated transcript (P<0.001)when compared with patients with non-ST-segment-elevation 25035150 LncRNADisease
EL0869 MIAT diabetes mellitus-induced microvascular dysfunction qPCR, RIP diabetic retinas and endothelial cells cultured in high glucose medium up-regulated expression This study highlights the involvement of lncRNA-MIAT in pathological angiogenesis and facilitates the development of lncRNA-directed diagnostics and therapeutics against neovascular diseases. 25587098
EL0869 MIAT paranoid schizophrenia two-stage association analysis sample from patients with paranoid schizophrenia N/A expression Long non-coding RNAs (LncRNAs) are involved in multiple processes critical to normal cellular function and dysfunction of lncRNA MIAT may contribute to the pathophysiology of schizophrenia. The present studies showed that lncRNA MIAT was a novel susceptibility gene for paranoid schizophrenia in the Chinese Han population. 26004688
EL0870 Miat neuropsychiatric disorders RNA-seq, qRT-PCR, knockdown, ChIP, RIP prefrontal cortex of adult mice down-regulated expression lncRNAs plays an important role in the epigenetic regulation of adaptive behavior, and the perturbation of Gomafu may be related to anxiety and the development of neuropsychiatric disorders 25792222
EL0872 MINA esophageal squamous cell carcinoma N/A N/A N/A regulation Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? 24757675 LncRNADisease
EL0872 MINA gastric cancer N/A N/A N/A regulation Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? 24757675 LncRNADisease
EL0872 MINA lung cancer N/A N/A N/A regulation Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? 24757675 LncRNADisease
EL0872 MINA hepatocelluar carcinoma N/A N/A N/A expression Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma.? 24757675 LncRNADisease
EL0873 MINCR Burkitt's lymphoma knockdown two MYC-inducible cell lines and a cohort of 91 B-cell lymphomas with or without genetic variants resulting in MYC overexpression N/A interaction MINCR knockdown is associated with an impairment in cell cycle progression. Differential gene expression analysis after RNAi showed a significant enrichment of cell cycle genes among the genes down-regulated after MINCR knockdown. Down-regulation of Aurora kinases A and B and chromatin licensing and DNA replication factor 1 may explain the reduction in cellular proliferation observed on MINCR knockdown. 26351698
EL0874 MIR100HG myopia N/A N/A N/A locus LOC399959 was identified within a 200-kb DNA encompassing rs577948. 19779542 LncRNADisease
EL0874 MIR100HG acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer
EL0877 MIR155HG chronic lymphocytic leukemia N/A N/A N/A Interaction MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. 21296997 LncRNADisease
EL0877 MIR155HG glioma qPCR etc. cell lines(U251, U87) down-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
EL0878 MIR17HG cancer N/A N/A N/A locus Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor. 20300951 LncRNADisease
EL0878 MIR17HG syndromic developmental defect N/A N/A N/A locus Here we report the identification of germline hemizygous deletions of MIR17HG, encoding the miR-17~92 polycistronic miRNA cluster, in individuals with microcephaly, short stature and digital abnormalities. 21892160 LncRNADisease
EL0878 MIR17HG diffuse large B-cell lymphoma qPCR, Northern blot etc. cell lines (OCI-Ly4, OCI-Ly7, OCI-ly8 etc.) up-regulated locus C13orf25 (MIR17HG) is a target for 13q31-q32 amplification in malignant lymphoma. 15126345 LncRNADisease Lnc2Cancer
EL0879 MIR21 laryngeal squamous cell carcinoma N/A N/A N/A N/A The expression of exosomal miR-21 and HOTAIR was significantly higher in patients with laryngeal squamous cell carcinomaLSCC than those with vocal cord polyps; The patients with lymph node metastasis had higher serum exosomal miR-21 and HOTAIR expressions than those without. 25099764 LncRNADisease Lnc2Cancer
EL0880 MIR31HG breast cancer qPCR etc. cell line (MCF10A) down-regulated epigenetics miR-31 and its host gene lncRNA LOC554202 (MIR31HG) are regulated by promoter hypermethylation in triple-negative breast cancer.Both miR-31 and the host gene LOC554202 are down-regulated in the TNBC cell lines of basal subtype and over-expressed in the luminal counterparts. 22289355 LncRNADisease Lnc2Cancer
EL0880 MIR31HG breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue, cell lines (MDA-MB-231, MDA-MB-435S etc.) up-regulated regulation Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. 24631686 LncRNADisease Lnc2Cancer
EL0880 MIR31HG gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, MKN45, GES-1) down-regulated interaction We found that MIR31HG expression is decreased in gastric cancer tissues and associated with larger tumor size and advanced pathological stage. Patients with lower MIR31HG expression had a relatively poor prognosis. Furthermore, ectopic over-expression of MIR31HG could inhibit gastric cancer (GC) cell proliferation both in vitro and in vivo, while knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. 26692098 Lnc2Cancer
EL0880 MIR31HG colorectal cancer qPCR, Western blot, knockdown, IHC, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, DLD1, SW480, RKO, HT-29) down-regulated interaction LOC554202 was significantly downregulated in cancerous tissues and CRC cell lines compared with adjacent normal tissue and a normal human intestinal epithelial cell line. Low LOC554202 expression was closely associated with advanced pathologic stage and a larger tumor size. The overexpression of LOC554202 decreased the cell proliferation and induced apoptosis in vitro and hindered tumorigenesis in vivo. LOC554202 regulated cell apoptosis partly through the activation of specific caspase cleavage cascades. 26362196 Lnc2Cancer
EL0881 MIR4435-2HG lung cancer microarray, qRT-PCR lung cancer tissues and A549 cell lines up-regulated expression We observed a significant reduction in cell viability in lung cancer cells and a slow growth in the tumorigenesis following AK001796 knockdown. We also found that AK001796 knockdown caused a cell-cycle arrest, with significant increases in the percentage of cells in G0/G1 in lung cancer cells. Reduced lncRNA AK001796 level potentially impaired the inhibitory effect of resveratrol on cell proliferation. 25888808
EL0882 MIR7-3HG liver cancer microarray, qPCR etc. liver cancer tissue, cell lines (Huh7, Bel7402, Bel7721, HepG2 etc.) down-regulated N/A Compared with normal human hepatocytes and adjacent noncancerous tissues, uc002mbe.2 expression level was significantly lower in the HCC cell lines and liver cancer tissues. The TSA-induced uc002mbe.2 expression was positively correlated with the apoptotic effect of TSA in HCC cells. Therefore, TSA-induced apoptosis of HCC cells is uc002mbe.2 dependent and reduced expression of uc002mbe.2 may be associated with liver carcinogenesis. 23643933 Lnc2Cancer
EL0882 MIR7-3HG hepatocelluar carcinoma N/A N/A N/A expression Besides, another study showed that liver cancer-downregulated lncRNA uc002mbe.2 could be induced by trichostatin A (TSA) treatment and its expression is positively correlated with the apoptotic effect of TSA in HCC cells. 24296588 LncRNADisease
EL0883 MIR99AHG acute megakaryoblastic leukemia qPCR etc. blood, cell lines (CMK, Meg-01, K562, HT1080 and 293 T etc.) up-regulated N/A Here we report that lncRNAs MONC and MIR100HG are highly expressed in AMKL blasts. The transcripts were mainly localized in the nucleus and their expression correlated with the corresponding miRNA clusters. Knockdown of MONC or MIR100HG impeded leukemic growth of AMKL cell lines and primary patient samples. Our study reveals an unprecedented function of lncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. 25027842 Lnc2Cancer
EL0884 Mira mixed lineage leukemia 1 N/A mouse embryonic stem cells (mESC) N/A N/A the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin. 21925392
EL0885 MKRN3-AS1 Prader-Willi syndrome N/A N/A N/A epigenetics ZNF127 and ZNF127AS are imprinted genes that may be associated with some of the clinical features of the polygenic Prader-Willi syndrome. 10196367 LncRNADisease
EL0932 MNX1-AS1 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL0932 MNX1-AS1 colorectal cancer microarray, qPCR, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, RKO, HT29, SW620 etc.) up-regulated expression Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. 25663692 Lnc2Cancer
EL0933 MR1 Loeys-Dietz syndrome (LDS) RT-PCR aortic aneurysm patients differential expression interaction LncRNA AK056155 was differentially expressed in peripheral blood circulating endothelial cells between normal patients and LDS patients by bioinformatics. AK056155 was also overexpressed in aortic aneurysm patients by RT-PCR. 26617788
EL0934 MRAK052686 Nonalcoholic fatty liver disease N/A N/A N/A N/A Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles. MRAK052686, was found strongly correlated with the antioxidant factor Nrf2, and both genes were down-regulated by the steatotic liver. The reduced expression of MRAK052686 and Nrf2 was completely reversed by BBR treatment, suggesting a new mechanism accounting for the therapeutic effect of BBR. 25623289 LncRNADisease
EL0937 MSUR1 amyotrophic lateral sclerosis 3 RACE,Northern blot ,Western blot nontransgenic (strain B6SJLF1/J) mice N/A expression In vitro expression experiments show that MSUR1 is able to rescue SOD1(G93A)-mediated cell death. Expression of MSUR1 significantly reduces SOD1(G93A)-induced free radical levels and oxidative damage. Further, MSUR1 can reduce hydrogen peroxide-mediated cytotoxicity. MSUR1 does not encode a protein, suggesting its role as a functional noncoding RNA 17957031
EL0940 MT1DP liver cancer qPCR, Western blot, Luciferase reporter assay etc. cell lines (SMMC-7721, Bel-7402, Huh7, HepG2, DLD-1, LS174T) down-regulated interaction Overexpression of MT1DP resulted in reduced cell proliferation and colony formation in soft agar, but increased apoptosis in liver cancer cells, whereas knockdown of this lncRNA had the opposite effetc, indicating that MT1DP acts as a tumor suppressor. Furthermore, MT1DP was revealed as a negative regulator of Alfa-fetoprotein (AFP), a classic liver cancer tumor marker, through inhibiting protein synthesis of Forkhead box A1 (FoxA1), an important transcription factor in liver development and cancer progression. 25261601 Lnc2Cancer
EL0950 MVIH hepatocelluar carcinoma N/A N/A N/A regulation Dr. Yuan et al. found that lncRNA-MVIH could promote tumor growth and intrahepatic metastasis by contributing to active angiogenesis both?in vitro?and?in vivo?through the inhibition of phosphoglycerate kinase 1 (PGK1) secretion 24757675 LncRNADisease
EL0950 MVIH hepatocelluar carcinoma N/A N/A N/A expression Yuan et al discovered that the lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma. 24829860 LncRNADisease
EL0950 MVIH hepatocelluar carcinoma qPCR etc. HCC tissues up-regulated N/A In this study, we found that lncRNA MVIH was generally overexpressed in HCC. In a cohort of 215 HCC patients, the overexpression of MVIH was associated with frequent microvascular invasion and a higher tumor node metastasis stage as well as decreased recurrence-free survival (RFS) and overall survival. We also found that MVIH could promote tumor growth and intrahepatic metastasis by activating angiogenesis in mouse models. Subsequent investigations indicated that MVIH could activate tumor-inducing angiogenesis by inhibiting the secretion of phosphoglycerate kinase 1(PGK1). 22706893 Lnc2Cancer
EL0950 MVIH breast cancer qPCR, knockdown, Flow cytometry assay etc. breast cancer tissue, cell lines (MDA-MB-231, MCF-7, T47D, BT-549, UACC-812) up-regulated interaction Our research revealed that the expression levels of MVIH in breast cancer tissues were higher than in adjacent noncancerous tissues, and high MVIH expression was correlated with Ki67 expression. Moreover, breast cancer patients with high MVIH expression levels showed poor overall survival and disease-free survival. Multivariate analysis results indicated that MVIH was an independent prognostic factor in breast cancer. In addition, upregulated MVIH expression levels promoted cell proliferation and cell cycle, and inhibited cell apoptosis, while reduced MVIH expression showed the converse. 26555546 Lnc2Cancer
EL0950 MVIH non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1, NCI-H1975, H1299 etc.) up-regulated regulation Long?non-coding?RNA?MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. 24793017 LncRNADisease Lnc2Cancer
EL0950 MVIH microvascular invasion in hepatocellular carcinoma real-time polymerase chain reaction (PCR), Luciferase reporter assay and RNA immunoprecipitation experiment tumor tissue of HCC patients and in HCC cells, including SMMC7721 and HepG2 cells. up-regulated expression Si-MVIH inhibited HCC cell viability and promoted cell apoptosis, but this effect was reversed by miR-199a inhibitor. In nude mice with transplantation, the tumor volume was reduced by si-MVIH, and miR-199a inhibitor canceled this decrease. 26347410
EL0951 MYCNOS neuroblastoma qPCR, Western blot etc. neuroblastoma tissue up-regulated expression Both DeltaMYCN and MYCNOS are expressed in all NBs examined. In NBs with MYCN-amplification, these transcripts are significantly higher expressed. the ratio of MYCNOS:MYCN expression is directly correlated with NB disease stage (p = 0.007). In the more advanced NB stages and NBs with MYCN-amplification, relatively more MYCNOS is present as compared to MYCN. Expression of the antisense gene MYCNOS might be relevant to the progression of NB. 19615087 LncRNADisease Lnc2Cancer
EL0952 MYCNUT neuroblastoma qPCR, knockdown etc. neuroblastoma tissue up-regulated N/A The lncUSMycN gene was coamplified with MYCN in 88 of 341 human neuroblastoma tissues. lncUSMycN RNA bound to the RNA-binding protein NonO, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of lncUSMycN and NonO expression in human neuroblastoma tissues independently predicted poor patient prognoses. Treatment with antisense oligonucleotides targeting lncUSMycN in neuroblastoma-bearing mice statistically significantly hindered tumor progression. 24906397 Lnc2Cancer
EL0954 MYHAS osteosarcoma microarray, qPCR etc. primary osteosarcoma tissue down-regulated N/A The results demonstrated that ASLNC21868, ASLNC22124, ASLNC23844, ASLNC24587, BE503655 and BC050642 were over-regulated and that ASLNC00339, ASLNC11435, ASLNC13387 and ASLNC18814 were under-regulated in the osteosarcoma samples compared with normal samples. The qPCR results and microarray data are consistent. 23466354 Lnc2Cancer
EL0955 MYLK-AS1 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL0956 n335550 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue down-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0957 n340790 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0958 n386477 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL0959 NALT1 pediatric T cell acute lymphoblastic leukemia CCK8 assay and EDU stain, western blot pediatric T cell acute lymphoblastic leukemia cells N/A interaction Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain. Gal4-λN/BoxB reporter system revealed that the nuclear located NALT could function as a transcription activator which caused an activation of NOTCH signal pathway as confirmed by western blot. 26330272
EL0960 NAMA papillary thyroid carcinoma qPCR, knockdown, RIP, FCA etc. PTC tissue, cell line (IHH-4) down-regulated expression The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. 26323637 Lnc2Cancer
EL0960 NAMA papillary thyroid carcinoma qPCR, Western blot, Northern blot, knockdown etc. PTA tissue tissue, cell lines (NPA87, K1, K2 etc.) down-regulated expression Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest. 17415708 LncRNADisease Lnc2Cancer
EL0961 NBAT1 breast cancer microarray, qPCR, Western blot, RIP, ChIP etc. cell lines (MCF-7, T47D, ZR75-1, BT-474, MDA-MB-453, BT-549, SK-BR-3 etc.) down-regulated interaction Here, we report that NBAT1 is down-regulated in various types of cancer. Particularly, reduced NBAT1 in breast cancer is associated with tumor metastasis and poor patient prognosis. In vitro, ectopic NBAT1 inhibits migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells. 26378045 Lnc2Cancer
EL0961 NBAT1 neuroblastoma N/A N/A N/A N/A The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Loss of NBAT-1 increases cellular proliferation and invasion. 25517750 LncRNADisease
EL0961 NBAT1 clear cell renal cell carcinoma qPCR, knockdown etc. ccRCC tissue, cell lines (786-O, ACHN, Caki-1 etc.) down-regulated expression NBAT-1 expression is significantly decreased in ccRCC tissues and renal cancer cells compared with adjacent normal tissues and normal human proximal tubule epithelial cell line HK-2, and its low level is associated with advanced features and poor prognosis. NBAT-1 is a novel molecular correlated with ccRCC progression and it may represent a prognostic biomarker and therapeutic target in renal cancer diagnosis and treatment. 26097558 Lnc2Cancer
EL0962 NBR2 cancer N/A N/A down-regulated interaction involving checked cell cycling, altered apoptosis/autophagy response, and tumor development in vivo 26999735
EL0963 ncC11orf49 renal cell carcinoma microarray, qPCR, Western blot etc. RCC tissue up-regulated N/A Four lncRNAs mapping to intronic regions, namely ncC11orf49, ncHDAC5, ncRAB31 and ncSRPK1, showed a significant (p <0.05) differential expression between tumor and nontumor paired samples as measured by qPCR. 24238219 Lnc2Cancer
EL0964 ncHDAC5 renal cell carcinoma microarray, qPCR, Western blot etc. RCC tissue up-regulated N/A Four lncRNAs mapping to intronic regions, namely ncC11orf49, ncHDAC5, ncRAB31 and ncSRPK1, showed a significant (p <0.05) differential expression between tumor and nontumor paired samples as measured by qPCR. 24238219 Lnc2Cancer
EL0965 ncNRFR colorectal cancer qPCR, Northern bolt, in vitro knockdown etc. colonic epithelial cell tumor tissue up-regulated N/A Stable overexpression of ncNRFR in non-transformed, conditionally immortalized mouse colonocytes results in malignant transformation, as determined by growth in soft agar and formation of highly invasive tumors in nude mice. Moreover, ncNRFR appears to inhibit the function of the tumor suppressor let-7. These results suggest precise regulation of ncNRFR is necessary for proper cell growth in the colonic crypt, and its misregulation results in neoplastic transformation. 24045012 Lnc2Cancer
EL0966 ncRAB31 renal cell carcinoma microarray, qPCR, Western blot etc. RCC tissue up-regulated N/A Four lncRNAs mapping to intronic regions, namely ncC11orf49, ncHDAC5, ncRAB31 and ncSRPK1, showed a significant (p <0.05) differential expression between tumor and nontumor paired samples as measured by qPCR. 24238219 Lnc2Cancer
EL0969 NCRUPAR gastric cancer qPCR etc. gastric cancer tissue down-regulated N/A The level of ncRuPAR in gastric cancer was low, and its expression level was associated with invasion depth, lymph node metastasis, distant metastasis, tumor size, and TNM stage. These findings indicate that ncRuPAR might be a potential marker for gastric cancer diagnosis. ncRuPAR might also be a tumor suppressor because it regulates the expression of PAR-1. 24817013 Lnc2Cancer
EL0969 NCRUPAR colorectal cancer qPCR, Immunohistochemistry etc. CRC tissue down-regulated interaction Our results indicated that the expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. The expression of ncRuPAR was significantly correlated with lymph node metastasis, distant metastasis, Duck's stage, differentiation, and TNM stage and was potentially negatively associated with the mRNA levels and EI scores of PAR-1. 25119598 Lnc2Cancer
EL0970 ncSRPK1 renal cell carcinoma microarray, qPCR, Western blot etc. RCC tissue up-regulated N/A Four lncRNAs mapping to intronic regions, namely ncC11orf49, ncHDAC5, ncRAB31 and ncSRPK1, showed a significant (p <0.05) differential expression between tumor and nontumor paired samples as measured by qPCR. 24238219 Lnc2Cancer
EL0972 NDM29 neuroblastoma N/A N/A N/A expression In humans, ndm29 maps in a genomic region whose deletion has been shown to be involved in neuroblastoma development. 16000168
EL0972 NDM29 neuroblastoma qPCR etc. cell lines (NB, NIE-115, SKNBE2 etc.) up-regulated expression The synthesis of a pol III-transcribed noncoding (nc) RNA (NDM29) strongly restricts NB development by promoting cell differentiation, a drop of malignancy processes. NDM29 expression leads to NB cell differentiation. 20581224 LncRNADisease Lnc2Cancer
EL0973 NEAT1 gastric adenocarcinoma GAC tissues and matched adjacent normal qRT-PCR gastric adenocarcinomas (GACs) up-regulated N/A Expression of NEAT1 lncRNA was enhanced in GACs and influence GAC progression by promoting tumor growth 26911892
EL0973 NEAT1 gastric cancer gastric cancer samples and cell lines by real-time PCR gastric cancer tissues and cell lines up-regulated N/A LncRNA NEAT1 was overexpressed in gastric cancer tissues and cell lines and corrected with clinical stage, histological type, lymph node metastasis, and distant metastasis 27095450
EL0973 NEAT1 paraspeckle disintegration Immunoprecipitation of Ribonucleoprotein Complex,knockdown HeLa cell down-regulated mutation Successful removal of MENepsilon/beta by a refined knockdown method resulted in paraspeckle disintegration. Furthermore, the reassembly of paraspeckles disassembled by transcriptional arrest appeared to be unsuccessful in the absence of MENepsilon/beta. 19188602
EL0973 NEAT1 ovarian cancer knockdown of NEAT1_1 OC patients and OVCAR-3 cell lines up-regulated N/A lncRNA NEAT1, whose expression was collaboratively controlled by HuR and miR-124-3p, could regulate ovarian carcinogenesis 27075229
EL0973 NEAT1 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL0973 NEAT1 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. 25997963 Lnc2Cancer
EL0973 NEAT1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL0973 NEAT1 nasopharyngeal carcinoma N/A NPC cell lines and tissues up-regulated N/A significantly upregulated in NPC cell lines and tissues 27020592
EL0973 NEAT1 frontotemporal lobar degeneration N/A N/A N/A Interaction Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT-1 noncoding RNAs. 20581224 LncRNADisease Lnc2Cancer
EL0973 NEAT1 Huntington's disease N/A N/A N/A expression LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD. 23346095 LncRNADisease
EL0973 NEAT1 AIDS N/A N/A N/A expression We found NEAT-1 to be one of several lncRNAs whose expression is changed by HIV-1 infection, and we have characterized its role in HIV-1 replication. 23362321 LncRNADisease
EL0973 NEAT1 amyotrophic lateral sclerosis N/A N/A N/A regulation The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. 23835137 LncRNADisease
EL0973 NEAT1 intrauterine growth restriction N/A N/A N/A expression The long non-coding RNA NEAT-1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development. 24280234 LncRNADisease
EL0973 NEAT1 oral squamous cell carcinoma N/A N/A N/A expression Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA2 in metastasized samples was prominent higher than the non-metastatic samples.? 24817925 LncRNADisease
EL0973 NEAT1 oral squamous cell carcinoma qPCR etc. OSCC tissues up-regulated N/A We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. 23292713 Lnc2Cancer
EL0973 NEAT1 non-small cell lung cancer qPCR etc. lung cancer tissue up-regulated expression The relative level of NEAT1 in NSCLC tissues was significantly elevated as compared to that of the adjacent non-cancer lung tissues. NEAT1 expression was positively correlated with patient age, lymphatic metastasis, vascular invasion and clinical TNM stage. lncRNA NEAT1 may act as a oncogene, which plays an important role in the tumorigenesis and deterioration of human NSCLC. 25854373 Lnc2Cancer
EL0973 NEAT1 hepatocelluar carcinoma qPCR etc. HCC tissue up-regulated interaction Our results revealed that NEAT1 appeared to have higher expression in the HCC tissues, compared with the adjacent non-cancerous liver tissues. High levels of NEAT1 promoted the clinical features of HCC, including the number of tumor nodes, metastasis, clinical TNM stage, the status of portal vein tumor embolus, vaso-invasion and the infiltration of tumor cells. Additionally, high NEAT1 expression levels were significantly associated with the expression level of MDTH, NM23 and MALAT1 26191242 Lnc2Cancer
EL0973 NEAT1 colorectal cancer qPCR etc. CRC tissue up-regulated expression Results showed that NEAT1 expression in colorectal cancer was up-regulated in 72.0% (172/239) cases compared with corresponding normal counterparts, and related to tumor differentiation, invasion, metastasis and TNM stage. 26314847 Lnc2Cancer
EL0973 NEAT1 glioma qPCR etc. glioma tissue up-regulated expression In our results, the relative level of NEAT1 expression was higher in cancer tissues compared with adjacent noncancerous tissues (p < 0.001). High NEAT1 expression was observed to be closely correlated with larger tumor size (p = 0.023), higher WHO grade (p = 0.005), and recurrence (p = 0.011). 26582084 Lnc2Cancer
EL0973 NEAT1 breast cancer qPCR, ISH etc. cell lines (MCF-7, MDA-MB-231, MDAMB-468) up-regulated expression Induction of NEAT1 in hypoxia also leads to accelerated cellular proliferation, improved clonogenic survival and reduced apoptosis, all of which are hallmarks of increased tumorigenesis. Furthermore, in patients with breast cancer, high tumor NEAT1 expression correlates with poor survival, all of which are hallmarks of increased tumorigenesis. 25417700 Lnc2Cancer
EL0973 NEAT1 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (SHEE, SHEEC) up-regulated expression We found that the expression of NEAT1 was higher in ESCC tissues and cells compared with the normal counterparts. Pearson analysis showed that elevated NEAT1 levels were extraordinarily correlated with the tumor size (P=0.026), lymph node metastasis (P=0.035) and clinical stage (P=0.004). 26609486 Lnc2Cancer
EL0973 NEAT1 acute promyelocytic leukemia qPCR, Western blot etc. blood, cell lines (NB4, NB4-R2, U937-PR9) down-regulated expression We found that NEAT1 is significantly repressed in de novo APL samples compared with those of healthy donors. We further provide evidence that NEAT1 expression was repressed by PML-RAR抅 Furthermore, significant NEAT1 upregulation was observed during all-trans retinoic acid (ATRA)-induced NB4 cell differentiation. 25245097 Lnc2Cancer
EL0973 NEAT1 Burkitt's lymphoma qPCR, Western blot, knockdown etc. blood up-regulated interaction NEAT1 expression levels were validated by qPCR, demonstrating high baseline expression (average Cp = 21.3), and confirming p53-dependent induction . lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. 25971364 Lnc2Cancer
EL0973 NEAT1 chronic lymphocytic leukemia qPCR, Western blot, knockdown etc. blood up-regulated expression NEAT1 expression levels were validated by qPCR, demonstrating high baseline expression (average Cp = 21.3), and confirming p53-dependent induction .lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. 25971364 Lnc2Cancer
EL0973 NEAT1 lung cancer qRT-PCR lung carcinoma cell lines N/A expression Our data indicate that miR-449a may function as a suppressor of lung cancer, and affects the expression of NEAT1 in lung cancer cells. 25818739
EL0973 NEAT1 non-small-cell lung cancer qRT-PCR patients suffering from non-small-cell lung cancer (NSCLC) up-regulated expression N/A 26448925
EL0973 NEAT1 obesity reexpression adipocyte-derived stem cells (ADSCs) isolated from wild-type and microRNA 140 (miR-140) knockout mice N/A expression MiR-140 knockout ADSCs have dramatically decreased adipogenic capabilities associated with downregulation of NEAT1 expression. Reexpression of NEAT1 in miR-140 knockout ADSCs is sufficient to restore their ability to undergo differentiation. 26457124
EL0973 NEAT1 prostate cancer RNA-seq, qPCR, ChIP etc. prostate cancer tissue, cell lines (LnCaP, PC3) up-regulated expression Among putatively ERa-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Prostate cancer cells expressing high levels of NEAT1 were recalcitrant to androgen or AR antagonists. NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription. 25415230 Lnc2Cancer
EL0974 Neat1 infertility N/A N/A N/A N/A Neat1 knockout (KO) mice stochastically fail to become pregnant despite normal ovulation. Unilateral transplantation of wild-type ovaries or the administration of progesterone partially rescued the phenotype, suggesting that corpus luteum dysfunction and concomitant low progesterone were the primary causes of the decreased fertility. In contrast to the faint expression observed in most of the adult tissues, Neat1 was highly expressed in the corpus luteum, and the formation of luteal tissue was severely impaired in nearly half of the Neat1 KO mice 25359727 LncRNADisease
EL0977 NKILA nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) up-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294008) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL0977 NKILA breast cancer qPCR, knockdown, RIP etc. breast cancer tissue down-regulated interaction Importantly, NKILA is essential to prevent over-activation of NF-B pathway in inflammation-stimulated breast epithelial cells. Furthermore, low NKILA expression is associated with breast cancer metastasis and poor patient prognosis. Therefore, lncRNAs can directly interact with functional domains of signaling proteins, serving as a class of NF-B modulators to suppress cancer metastasis. 25759022 Lnc2Cancer
EL0979 NONHSAT012762 triple-negative breast cancer microarray, qPCR etc. TNBC tissue up-regulated expression The results demonstrated that lncRNAs NONHSAT125629 and ENST00000503938 were upregulated and that XR_250621.1 and NONHSAT012762 were down-regulated in the tumor samples compared with NT samples. These qPCR results are consistent with the microarray data. 26078338 Lnc2Cancer
EL0980 NONHSAT037832 papillary thyroid carcinoma qPCR etc. PTC tissue, cell line (IHH-4, K1, B-CPAP, Nthyori 3-1) down-regulated expression The results suggested that the expression level of NONHSAT037832 was significantly decreased in PTC compared with paired noncancerous tissues (P < 0.01). And, NONHSAT037832 was also significantly downregulated in two PTC cell lines (K1 and IHH-4) compared to normal thyroid follicular epithelial cell line Nthy-ori 3-1 (P < 0.01). Downregulated NONHSAT037832 was significantly associated with lymph node metastasis (P = 0.015) and tumor size (P = 0.032). 26611646 Lnc2Cancer
EL0981 NONHSAT073641 vascular diseases knockdown and overexpression In vascular samples of patients with chronic thromboembolic pulmonary hypertension (CTEPH) up-regulated expression N/A 27124368
EL0982 NONHSAT123350 renal clear cell carcinoma qRT-PCR renal clear cell carcinoma (RCCC) N/A expression NONHSAT123350 could be involved in the pathogenesis of RCCC and its expression level was closely related to disease-free survival (DFS) and overall survival (OS) in patients without distant metastasis. 26765468
EL0983 NONHSAT125629 triple-negative breast cancer microarray, qPCR etc. TNBC tissue down-regulated expression The results demonstrated that lncRNAs NONHSAT125629 and ENST00000503938 were upregulated and that XR_250621.1 and NONHSAT012762 were down-regulated in the tumor samples compared with NT samples. These qPCR results are consistent with the microarray data. 26078338 Lnc2Cancer
EL0984 NONRATT021972 type 2 diabetes mellitus N/A Type 2 diabetes mellitus (T2DM) rat model, T2DM patient serum up-regulated interaction MWT and TWL in T2DM rats treated with NONRATT021972 siRNA were higher compared with those in T2DM rats. NONRATT021972 siRNA treatment may suppress the upregulated expression and activation of the P2X3 receptor and reduce the hyperalgesia potentiated by the pro-inflammatory cytokine TNF-α in T2DM rats. 26742527
EL0984 NONRATT021972 diabetic neuropathic pain NONRATT021972 siRNA treatment in type 2 DM rats diabetes mellitus (DM) group and control group up-regulated N/A NONRATT021972 siRNA treatment can decrease the expression levels of P2X7 mRNA and protein and inhibit the activation of satellite glial cells (SGCs) 27107575
EL0984 NONRATT021972 P2X7-mediated PC12 neuronal injury PC12 cells under OGD conditions PC12 cells N/A N/A Treatment with NONRATT021972 siRNA reversed the decreased viability of PC12 cells under OGD conditions 27100355
EL0986 NOS2 glioblastoma qPCR etc. glioblastoma tissue up-regulated expression anti-NOS2A is a lncRNA that is expressed in meningiomas and glioblastomas from a genomic locus that evolved by duplication of the NOS2A gene followed by internal DNA inversion. 18820242 LncRNADisease Lnc2Cancer
EL0986 NOS2 meningioma qPCR etc. meningioma tissue up-regulated expression anti-NOS2A is a lncRNA that is expressed in meningiomas and glioblastomas from a genomic locus that evolved by duplication of the NOS2A gene followed by internal DNA inversion. 18820242 LncRNADisease Lnc2Cancer
EL0987 np_17856 progressive kidney injury N/A N/A N/A regulation Real-time PCR confirmed these findings and revealed the functional link between Smad3-dependent lncRNAs np_5318/np_17856 and progressive kidney injury. 24262754 LncRNADisease
EL0988 np_5318 progressive kidney injury N/A N/A N/A regulation Real-time PCR confirmed these findings and revealed the functional link between Smad3-dependent lncRNAs np_5318/np_17856 and progressive kidney injury. 24262754 LncRNADisease
EL0989 NPAP1 Angelman syndrome N/A N/A N/A expression C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. 17337158 LncRNADisease
EL0989 NPAP1 Prader-Willi syndrome N/A N/A N/A expression C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. 17337158 LncRNADisease
EL1006 NPPA-AS1 cardiovascular disease N/A N/A N/A N/A The NPPA-AS lncRNA has been shown to be a modulator of the alternative splicing of the NPPA gene. This lncRNA thus has potential to be involved in cardiovascular disease 22817756 LncRNADisease
EL1007 NPTN-IT1 hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue down-regulated N/A AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. 21769904 Lnc2Cancer
EL1007 NPTN-IT1 hepatocelluar carcinoma N/A N/A N/A expression Importantly, another lncRNA-LET (lncRNA low expression in tumor) is found to play a critical role in hypoxia-induced metastasis in HCC 24296588 LncRNADisease
EL1007 NPTN-IT1 gastric cancer qPCR etc. gastric cancer tissue down-regulated expression We found that lncRNA LET expression was markedly down-regulated in tumor tissues compared with adjacent non-tumor tissues, and associated with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage. Univariate and multivariate analyses showed that low lncRNA LET expression was an independent poor prognostic factor for gastric cancer patients. 25674261 Lnc2Cancer
EL1007 NPTN-IT1 cervical cancer qPCR etc. cervical cancer tissue down-regulated expression The results showed that lncRNA LET expression in cervical cancer tissues was significantly down-regulated compared with the adjacent non-tumor tissues (P < 0.05). Decreased lncRNA LET expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion (P < 0.05), but not other clinical characteristics. 25755778 Lnc2Cancer
EL1007 NPTN-IT1 gallbladder cancer qPCR, Western blot, FCA etc. gallbladder cancer tissue, cell lines (GBC-SD, SGC-996, NOZ, EH-GB2) down-regulated expression In the present study, an obvious down-regulation of lncRNA-LET was observed in gallbladder cancer compared to their adjacent normal tissues. Meanwhile, patients with low expression of lncRNA-LET have significantly poorer prognosis than those with high expression. We confirmed that hypoxia decreased lncRNA-LET levels in gallbladder cancer cells. Moreover, lncRNA-LET overexpression was further validated to inhibit the invasion of gallbladder cancer cells under hypoxic or normoxic conditions in vitro. We demonstrated that lncRNA-LET overexpression conferred a proliferative advantage to tumor cells under hypoxic conditions. 25213660 Lnc2Cancer
EL1007 NPTN-IT1 lung squamous cell carcinoma qPCR, Western blot, in vitro knockdown, RIP etc. LSCC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) down-regulated expression In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. 23395002 LncRNADisease Lnc2Cancer
EL1007 NPTN-IT1 colorectal cancer qPCR, Western blot, in vitro knockdown, RIP etc. CRC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) down-regulated expression Aberrant Expression of lncRNA-LET in Tumor Tissue. In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. 23395002 LncRNADisease Lnc2Cancer
EL1007 NPTN-IT1 hepatocelluar carcinoma qPCR, Western blot, in vitro knockdown, RIP etc. HCC tissue, cell lines (QSG-7701, LO2, SMMC-7721 etc.) down-regulated expression In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. 23395002 LncRNADisease Lnc2Cancer
EL1007 NPTN-IT1 nasopharyngeal carcinoma qPCR, Western blot, knockdown etc. NPC tissue, cell lines (CNE2, HNE2) down-regulated interaction We found that lncRNA-LET was significantly downregulated in nasopharyngeal carcinoma (NPC) tissues compared with corresponding normal tissues. Decreased LET expression is significantly correlated with advanced clinical stage, larger tumor size, increased lymph node tumor burden, and poor survival of NPC patients. Knockdown of LET promoted NPC cells proliferation and inhibited cell apoptosis. Importantly, we found lncRNA-LET is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter. The expressions of EZH2 and lncRNA-LET are significantly inversely correlated in NPC tissues. 26243049 Lnc2Cancer
EL1007 NPTN-IT1 esophageal squamous cell carcinoma reverse transcription‑quantitative polymerase chain reaction primary ESCC tissues and healthy tissues down-regulated N/A LET was observed to inhibit the migration and invasion of ESCC cells 26935396
EL1008 NR_038125 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1009 NR024118 rheumatoid arthritis RT-RCR, overexpression Severe polyarticular arthritis was induced in Balb/c female mice N/A expression NR024118 overexpression and interference significantly changed SOCS3 expression and NR024118 interference could reverse regulation of shikonin on SOCS3, proinflammatory cytokines, and MMPs expression level in MH7A cells. 26640499
EL1011 NRG1 lung cancer qPCR etc. lung cancer tissue up-regulated N/A High expression was observed in cancer tissues, which was consistent with our previous study that NRG1 was highly expressed in lung cancer induced by nickel. NRG1 was located on chromosome 2q12, within intron2 of ADAMTS6, a disintegrin and metalloproteinase with thrombospondin motifs. And, NRG1 had a high level of homology (76 %) to rat LINE1 sequence RL1.3 (long interspersed middle repetitive DNA) 22665269 Lnc2Cancer
EL1012 NRIR chronic hepatitis C qRT-PCR liver sample up-regulated N/A high serum iron concentration and correlated with higher hepatic expression of lncRNA NRIR 27125837
EL1013 NRON Down's syndrome N/A N/A N/A expression NRON is a lncRNA that mediates the cytoplasmic to nuclear shuttling of the NFAT transcription factor . In animal models, deregulation of the DSCR1 and DYRK1A genes act synergistically to prevent nuclear occupancy of NFATc transcription factors leading to reduced NFATc activity and to many features of DS, suggesting a potential link between NRON activity and DS pathophysiology. 16141075 LncRNADisease
EL1013 NRON AIDS N/A N/A N/A N/A The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Its expression was significantly altered following HIV-1 infection. Its levels were reduced by the early viral accessory protein Nef and increased by the late protein Vpu. 25728138 LncRNADisease
EL1019 OGT colon cancer N/A N/A up-regulated N/A HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. 24037088
EL1021 OR3A4P gastric cancer microarray analysis qRT-PCR gastric cancer cells up-regulated N/A significantly associated with lymphatic metastasis; OR3A4 promoted cancer cell growth 26863570
EL1022 ORAOV1 nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) up-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294009) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL1023 OS9 pancreatic ductal adenocarcinoma qPCR, Western blot, Luciferase reporter assay, ELISA etc. PDAC tissue down-regulated N/A the ENST00000480739 expression level was remarkably 25314054 LncRNADisease Lnc2Cancer
EL1027 OVAAL ovarian cancer RNA-seq, qPCR etc. ovarian cancer tissue down-regulated N/A OVAL expression was low or absent in both normal fallopian tube (Figure S3 in File S1) and in the majority of tumors, including most cases with wide 1q amplification. However, focal amplification of the OVAL locus coincided strikingly with OVAL transcriptional activation. 24265805 Lnc2Cancer
EL1028 P14695 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1029 P16984 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1030 P19780 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1031 P23099 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1032 P24363 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1033 P28210 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1034 P2rx3 type 2 diabetes mellitus rat lncRNA array profiling type 2 diabetic rats up-regulated N/A lncRNA uc.48+ siRNA regulating the expression of P2X7 and ERK signaling in SCG. 27118262
EL1034 P2rx3 diabetes mellitus reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blotting diabetic rat dorsal root ganglia (DRG) Diabetes mellitus (DM) patients' serum samples up-regulated interaction Uc.48+ siRNA treatment may alleviate the DNP by inhibiting the excitatory transmission mediated by the P2X3 receptor in DRG. 26686228
EL1035 P33863 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1036 P4091 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1037 P6391 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1038 P6488 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1039 P700 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1040 P8611 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) down-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1041 P8725 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1042 P8860 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1043 P9745 hepatocelluar carcinoma microarray, qPCR etc. primary HCC tissue, cell lines (MHCC97H, MHCC97L) up-regulated expression We randomly selected 15 out of the significantly differentially expressed LncRNAs in P3 and validated their expression levels in cell lines (MHCC97H and MHCC97L). In those LncRNAs, nine of which were upregulated (P23099, P8860, P14695, P28210, P4091, P6391, P24363, P8725, and P9745) and six of which were downregulated (P6488, P700, P8611, P16984, P19780, and P33863). 25900874 Lnc2Cancer
EL1044 PACERR cancer ChIP, qPCR, RACE primary human mammary epithelial cells and monocyte/macrophage cell lines N/A interaction The lncRNA associates with p50, a repressive subunit of NF-κB, and occludes it from the COX-2 promoter, potentially facilitating interaction with activation-competent NF-κB p65/p50 dimers. 24843008
EL1045 PAN Kaposi's sarcoma N/A N/A N/A expression KSHV infected cells express a highly abundant long noncoding transcript referred to as polyadenylated nuclear RNA (PAN RNA). 23468496 LncRNADisease
EL1046 PANDAR breast cancer knockdown of PANDAR breast cancer tissues and cell lines up-regulated N/A PANDAR in regulating the progression of breast cancer 26927017
EL1046 PANDAR cancer N/A N/A N/A expression Another DNA damage-responsive, p53-induced lncRNA that lies upstream of p21, PANDA (P21 associated ncRNA DNA damage activated), is also implicated in the repression of pro-apoptotic genes, such as FAS and BIK, by acting as a decoy for the transcription factor NF-YA. In some cancer types, p53 mutations have been found that maintain the protein's ability to induce the PANDA pathway (and its antiapoptotic effects) while abolishing its ability to induce p21 and its promotion of cell-cycle arrest, thus leading to increased tumor cell survival (Hung et al. 2011). 23463798 LncRNADisease
EL1046 PANDAR hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (HCCLM3, Hep3B, HepG2) up-regulated expression PANDAR was overexpressed in HCC tissues and cell lines. Moreover, its expression level was significantly correlated with liver cirrhosis, HBsAg, AFP, tumor nodule, vascular invasion and TNM stage. PANDAR overexpression was associated with poorer survival and shorter recurrence and served as an independent prognostic marker of patients with HCC. 26054684 Lnc2Cancer
EL1046 PANDAR non-small cell lung cancer qPCR, Western blot, RIP etc. lung cancer tissue, cell lines (A549, SPC-A1, NCI-H1299, SK-MES-1 etc.) down-regulated interaction In a cohort of 140 NSCLC patients, decreased PANDAR expression was negatively correlated with greater tumor size (P<0.001) and advanced TNM stage (P=0.002). Moreover, PANDAR could serve as an independent predictor for overall survival in NSCLC (P=0.015). PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. 25719249 Lnc2Cancer
EL1046 PANDAR gastric cancer Quantitative Real-time PCR 100 paired gastric cancer tissues up-regulated N/A high expression of PANDAR was correlated with depth of invasion, TNM stage and lymphatic metastasis 26898439
EL1047 PARTICL low-dose irradiation In situ hybridization, surface plasmon resonance, Bromouridine tracing samples from radiotherapy-treated patients up-regulated expression Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. 25900080
EL1049 PAWR acute lymphoblastic leukemia qPCR, Western blot, knockdown etc. T-ALL jurkat cell up-regulated N/A T-ALL-R-LncR1 was not observed in human normal tissues. However, an obvious expression was observed in some tumor tissues. T-ALL-R-LncR1 was markedly expressed in neoplastic T lymphocytes of 11 cases out of 21 children with T-ALL, indicating that T-ALL-R-LncR1 might be associated with T-ALL. T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells 23906015 Lnc2Cancer
EL1050 PAX8-AS1 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL1051 PCA3 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1051 PCA3 prostate cancer N/A N/A N/A expression Measurement of lncRNA PCA3 in patient urine samples has been shown to allow more sensitive and specific diagnosis of prostate cancer than the widely used marker prostate-specific antigen (PSA). 15245811 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A expression The PCA3 assay is insensitive to pre-analytical factors, performs well analytically and correctly classifies a high percent of subjects with known prostate cancer status across research sites. 18054202 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A expression The probability of a positive repeat biopsy increases with rising PCA3 scores. The PCA3 score was superior to %fPSA for predicting repeat prostate biopsy outcome and may be indicative of clinical stage and significance of pCa. 18602209 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A expression Patients with a positive biopsy showed significantly higher PCA3 values. 20424427 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A expression PCA3 scores were significantly lower in low-volume disease and insignificant PCa. Higher PCA3 scores were associated with aggressive disease. 20980098 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A expression Diagnostic marker 24373479 LncRNADisease
EL1051 PCA3 prostate cancer N/A N/A N/A N/A PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 2) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer. 24667321 LncRNADisease
EL1051 PCA3 prostate cancer Northern blot etc. prostate cancer tissue up-regulated expression PCA3 is a highly prostate cancer-specific gene. 14607216 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer PROGENSA PCA3 assay etc. blood, urine up-regulated expression A PCA3 score threshold of 20 may have the highest utility for selecting men with clinically insignificant prostate cancer in whom active surveillance may be appropriate; a PCA3 score threshold of 50 may be used to identify men at high risk of harbouring significant prostate cancer who are candidates for RP. 21883822 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression Upregulation of two new PCA3 isoforms in PCa tissues improves discrimination between PCa and BPH. 19319183 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression PCA3 mRNA is prostate cancer specific and shows increased expression in prostate cancer. 20114043 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression It was found that the levels of the mRNA expression of DD3(PCA3) were significantly higher (p<0.045) in patients with PCa than in patients with benign prostatic hyperplasia. 20332487 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR etc. blood differential expression mutation The presence of the (TAAA)n short tandem repeat polymorphisms in the PCA3 promoter region may be a risk factor for prostate cancer in the Chinese population. 21655300 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR, in vitro knockdown etc. cell lines (LNCaP, PC3, RWPE-1, PrEC etc.) up-regulated N/A PCA3 is a non-coding RNA (ncRNA) that is highly expressed in prostate cancer (PCa) cells, LNCaP siPCA3-transfected cells significantly inhibited cell growth and viability, and increased the proportion of cells in the sub G0/G1 phase of the cell cycle and the percentage of pyknotic nuclei, compared to those transfected with scramble siRNA (siSCr)-transfected cells. Our findings suggest that the ncRNA PCA3 is involved in the control of PCa cell survival, in part through modulating AR signaling, which may raise new possibilities of using PCA3 knockdown as an additional therapeutic strategy for PCa control. 23130941 Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR, Northern blot etc. BPH, prostatic tumor tissue up-regulated expression PCA3 is one of the most prostate cancer-specific genes yet described, and this makes DD3 a promising marker for the early diagnosis of prostate cancer and provides a powerful tool for the development of new treatment strategies for prostate cancer patients. 10606244 LncRNADisease Lnc2Cancer
EL1051 PCA3 prostate cancer qPCR, Northern bolt etc. prostate cancer tissue, cell lines (LNCap-AD, 22Rv1, PC-3, DU145, C4-2 etc.) up-regulated N/A qPCR was used to assess the PCA3 and MALAT-1 expression levels in an additional set of 10 pairs of PCa and adjacent normal tissues. Comparing the PCA3 and MALAT-1 expression levels in the 10 paired tissue samples revealed that PCA3 and MALAT-1 were highly expressed in most of the PCa tissues. Plasma lncRNAs probably exist in the form of fragments in a stable form. MD-miniRNA enters cell culture medium at measurable levels, and MD-miniRNA derived from human PCa xenografts actually enters the circulation in vivo and can be measured to distinguish xenografted mice from controls. 23726266 Lnc2Cancer
EL1051 PCA3 cancer qRT-PCR LNCaP cell up-regulated N/A PCA3 silencing modulates the expression of key cancer-related genes 26960690
EL1051 PCA3 prostate cancer RNA-seq, qPCR etc. prostate cancer tissue up-regulated N/A Consistent with the RNA-seq results, PCA3, FR0348383 and MALAT1 overexpression was found in 80% (32/40), 72.5% (29/40), and 82.5% (33/40) of the prostate cancers respectively, whereas decreased FR0257520 expression was found in 82.5% (33/40) of the prostate cancers. 22349460 Lnc2Cancer
EL1051 PCA3 prostate cancer Sequencing etc. prostate cancer tissue, blood(leukocytes) up-regulated N/A By PCR-based cloning and sequencing in paired peripheral blood leukocytes and prostate tissues,5 PCA3 TAAA STR polymorphisms and 8 genotypes were found in both peripheral blood leukocytes and prostate tissues, the carriers with more TAAA repeats were associated with increased risk for PCa than individuals having less TAAA repeats 25445501 LncRNADisease Lnc2Cancer
EL1052 PCAT1 prostate cancer microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. prostate tissue, cell lines (Du145-derived, RWPE-derived, LNCAP-derived, PC3-derived etc.) up-regulated regulation PCAT1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. 24473064 LncRNADisease Lnc2Cancer
EL1052 PCAT1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1052 PCAT1 prostate cancer N/A N/A N/A regulation They described PCAT1,a novel PCa lincRNA on 8q24, in the locality of well-characterized PCa risk-related SNPs and the c-MYC oncogene. 24146262 LncRNADisease
EL1052 PCAT1 prostate cancer N/A N/A N/A expression Putative marker and oncogene 24373479 LncRNADisease
EL1052 PCAT1 prostate cancer N/A N/A N/A regulation The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. 24531795 LncRNADisease
EL1052 PCAT1 colorectal cancer qPCR etc. CRC tissue up-regulated N/A Our results showed that PCAT-1 expression in CRC tissues was significantly upregulated compared with the matched normal tissues and the overexpression of PCAT-1 was found in 64 % (62/81) of CRC. In addition, there was a significant association between PCAT-1 expression and distant metastasis. More important, CRC patients with PCAT-1 higher expression have shown significantly poorer overall survival than those with lower PCAT-1 expression. In conclusion, our results suggest that high expression of PCAT-1 is involved in CRC progression and could be a novel biomarker of poor prognosis in patient with colorectal cancer. 23640607 Lnc2Cancer
EL1052 PCAT1 esophageal squamous cell carcinoma qPCR etc. ESCC tissue up-regulated interaction The expression of PCAT-1 was significantly higher in human ESCC compared with the adjacent noncancerous tissues (70.8 %, p < 0.01), and the high level of PCAT-1 expression was significantly correlated with invasion of the tumor (p = 0.024), advanced clinical stage (p = 0.003), lymph node metastasis (p = 0.032), and poor prognosis. 25731728 Lnc2Cancer
EL1052 PCAT1 bladder cancer qPCR etc. bladder cancer tissue, cell lines (T24, 5637 etc.) up-regulated expression In this study, we found that PCAT-1 was up-regulated in bladder cancer compared to paired normal urothelium.PCAT-1 plays oncogenic roles. 25934337 Lnc2Cancer
EL1052 PCAT1 prostate cancer qPCR, Luciferase reporter assay, knockdown etc. cell lines (LNCaP) up-regulated regulation We show that PCAT-1 promotes prostate cell proliferation and that this phenotype is mediated through up-regulation of the cMyc protein (encoded by the MYC gene). Antagonism of cMyc is able to reverse PCAT-1mediated cell proliferation. We show that PCAT-1 regulates cMyc post-transcriptionally through the MYC 3' untranslated region (UTR). Further, we find a protetcive effetc of PCAT-1 on cMyc by interfering with the regulation of MYC by miR-34a. 25425964 Lnc2Cancer
EL1052 PCAT1 non-small cell lung cancer quantitative real-time PCR (QRT-PCR), suppression non-small cell lung cancer cells up-regulated expression PCAT-1 suppression using PCAT-1 small hairpin RNA (shRNA) with A549 cells inhibited cell proliferation, migration and invasion, while over-expression of PCAT-1 by synthetic plasmid vectors was shown to promote cell proliferation, migration and invasion. Our data suggested that PCAT-1 could play an oncogenic role in NSCLC progression. Silencing PCAT-1 is a potential novel therapeutic approach for lung cancer. 26770456
EL1052 PCAT1 prostate cancer RNA-seq, qPCR, Western blot etc. prostate cancer tissue, cell lines (VCaP, LNCaP) up-regulated expression PCAT1 is markedly overexpressed in a subset of prostate cancers, particularly metastases, and may contribute to cell proliferation in these tumors. 21804560 LncRNADisease Lnc2Cancer
EL1052 PCAT1 hepatocelluar carcinoma the reverse transcription-quantitative polymerase chain reaction HCC tissue samples and HepG2 and Bel‑7402 cell lines up-regulated N/A Overexpression of PCAT‑1 induced synthetic plasmid vectors 27035680
EL1053 PCAT18 prostate cancer microarray, qPCR, knockdown etc. cell lines (LTL313B, LTL313H etc.) up-regulated expression The most highly up-regulated transcript was LOC728606, a lncRNA now designated PCAT18. PCAT18 is specifically expressed in the prostate compared to 11 other normal tissues (p<0.05) and up-regulated in PCa compared to 15 other neoplasms (p<0.001). 24519926 LncRNADisease Lnc2Cancer
EL1054 PCAT29 prostate cancer microarray, qPCR etc. cell lines (Glutamax(Invitrogen), LNCaP, DU145 etc.) down-regulated N/A PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. PCAT29 as an androgen-regulated tumor suppressor in prostate cancer. 25030374 Lnc2Cancer
EL1054 PCAT29 prostate cancer qPCR, Western blot etc. cell lines (VCap, PC3M-luc, LNCaP etc.) down-regulated N/A This study reveals a novel tumor suppressive locus encoding two hormone-regulated lncRNAs, DRAIC and PCAT30, that are prognostic for a wide variety of cancer types.This study reveals a novel tumor suppressive locus encoding two hormone-regulated lncRNAs, DRAICand PCAT29, that are prognostic for a wide variety of cancer types. 25700553 LncRNADisease Lnc2Cancer
EL1055 PCAT5 prostate cancer RNA-seq, qPCR, knockdown etc. cell lines (PC-3, 22Rv1) up-regulated interaction In vitro validation of these alterations revealed a complex integrated phenotype affecting cell growth, migration, invasion, colony-forming potential and apoptosis. Our findings reveal a key molecular determinant of differences between PC and CRPC at the level of the transcriptome. Further, they establish PCAT5 as a novel oncogenic lncRNA in ERG-positive prostate cancers, with implications for defining CRPC biomarkers and new therapeutic interventions. 26282172 Lnc2Cancer
EL1056 PCAT6 triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
EL1056 PCAT6 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Both lncRNA showed positive correlation between gene expression and SCNA. The criteria of increasing expression from normal to primary to metastatic prostate cancer aimed to uncover lncRNA that may be important therapeutic targets for both primary and metastatic cancers. 23728290 Lnc2Cancer
EL1057 PCAT7 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Both lncRNA showed positive correlation between gene expression and SCNA. The criteria of increasing expression from normal to primary to metastatic prostate cancer aimed to uncover lncRNA that may be important therapeutic targets for both primary and metastatic cancers. 23728290 Lnc2Cancer
EL1058 PCGEM1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1058 PCGEM1 prostate cancer N/A N/A N/A expression PCGEM1 was originally discovered in a genome-wide gene expression screen as a cDNA sequence with prostate cancer overexpression and highly specific localization to glandular epithelial cells. 20951849 LncRNADisease
EL1058 PCGEM1 prostate cancer N/A N/A N/A regulation One of the earliest lncRNAs described in PCa, was PCGEM1(prostate cancer gene expression marker 1), a prostate-specific transcript encoded on 2q32 (40). One of the earliest lncRNAs described in PCa, was PCGEM1 (prostate cancer gene expression marker 1), a prostate-specific transcript encoded on 2q32 (40). 24146262 LncRNADisease
EL1058 PCGEM1 prostate cancer N/A N/A N/A regulation High-risk and predictive marker Oncogene 24373479 LncRNADisease
EL1058 PCGEM1 prostate cancer N/A N/A N/A N/A PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 1) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer. 24667321 LncRNADisease
EL1058 PCGEM1 prostate cancer N/A N/A N/A regulation The focus of this Nature report13 is on two PCa-associated lncRNAs: PCGEM1 and PRNCR1. They cooperate in regulating the function of the male hormone receptor, the androgen receptor (AR), which plays central role in PCa onset and progression. AR pathway is activated in advanced CaPs including castration-resistant prostate cancer (CRPC). 24713835 LncRNADisease
EL1058 PCGEM1 prostate cancer Northern blot etc. cell line (LNCaP) up-regulated N/A A prostate-specific and prostate cancer-associated noncoding gene, PCGEM1 regulates apoptosis. 16569192 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 14724589 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression The biomarkers had sensitivities ranging from 91% to 100%. Clinical specificities evaluated with the BPH tissue were the following: hTERT mRNA (93%), DD3 mRNA (57%), Survivin (29%) and PCGEM1 (14%). 16515751 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. cell lines (PC-3, DU145 etc.) up-regulated Interaction Phytosterol inhibition of PCGEM1 and cell growth and the overexpression of caveolin-1, suggests that poor disease prognosis anchors on the ability of caveolin-1 to regulate downstream oncogene(s) and apoptosis genes. 19186008 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression Expression profiles of genes in CRPC support a role for the transcriptional activity of the PCGEM1. 20868494 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. prostate cancer tissue differential expression mutation We found a significantly decreased risk of PCa for rs6434568 AC and AC/AA genotype, as well as rs16834898 AC and AC/CC genotype, compared with the CC and AA genotypes, respectively. 23459097 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR etc. cell lines (LNCaP) up-regulated N/A PCGEM1 overexpression is highly associated with prostate tumors. CGEM1 tumorigenic potential has been recently shown to be in part due to its ability to activate androgen receptor (AR). Here, we report a novel function of PCGEM1 that provides growth advantages for cancer cells by regulating tumor metabolism via c-Myc activation. PCGEM1 promotes glucose uptake for aerobic glycolysis, coupling with the pentose phosphate shunt to facilitate biosynthesis of nucleotide and lipid, and generates NADPH for redox homeostasis. 25512540 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR, Northern blot, FISH, ISH etc. prostate cancer tissue, cell lines (LNCaP, DU145, PC-3CaP etc.) up-regulated expression PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. 11050243 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer qPCR, RIP etc. prostate cancer tissue,cell lines (LNCaP, LNCaP-cds1, LNCaP-cds2, CWR22Rv1 etc.), tissues (prostate tumour tissues) up-regulated expression Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. 23945587 LncRNADisease Lnc2Cancer
EL1058 PCGEM1 prostate cancer RNA-seq, qRT-PCR N/A N/A N/A not implicated in castration resistant prostate cancer. 24727738
EL1058 PCGEM1 prostate cancer RT-PCR, luciferase reporter assay, MTT assay and flow cytometry, transwell assays LNCaP cells and noncancerous RWPE-1 prostate cells, (nu/nu) mouse model up-regulated interaction We demonstrate a reciprocal negative control relationship between PCGEM1 and miR-145 that regulates both LNCaP cell proliferation and nu/nu PCa tumor growth. 25200485
EL1059 PCNA-AS1 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Huh7, SMMC7721) up-regulated regulation Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma. 24704293 LncRNADisease Lnc2Cancer
EL1060 PCNCR1 prostate cancer N/A N/A N/A N/A Accumulating evidence indicated that prostate cancer non-coding RNA 1 (PCNCR1) lncRNA was identified in a gene deserton chromosome 8q24.2 and is associated with susceptibility to prostate cancer 22535282 LncRNADisease
EL1060 PCNCR1 prostate cancer N/A N/A N/A N/A PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 3) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer. 24667321 LncRNADisease
EL1061 PDLIM3 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1062 PDZRN3-AS1 type 2 diabetes mellitus N/A N/A N/A mutation SNP rs11128347 (C>G) in PDZRN3 is associated with African-Americans with type 2 diabetes. 21546767 LncRNADisease
EL1063 PEG10 diffuse large B-cell lymphoma qPCR, knockdown etc. DLBCL tissue, cell lines (OCI-LY-3, OCI-LY-7, OCI-LY-10 etc.) up-regulated expression We first found that the expression of PEG10 was upregulated in DLBCL tumorous tissues and that cell lines compared with the normal. Moreover, we illustrated that PEG10 was significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. 25864113 Lnc2Cancer
EL1063 PEG10 esophageal cancer qPCR, Western blot etc. esophageal cancer tissue, cell lines (EC9706, KYSE150) up-regulated expression LncRNA PEG10 was expressed at higher levels in esophageal cancer tissues than in adjacent non-neoplastic tissues (P<0.05). This relatively high expression was significantly associated with the occurrence of lymph node metastases (P<0.05). Apoptosis and migration rates were significantly decreased in two esophageal cancer cell lines (EC9706 and KYSE150) transfetced with si-LncRNA PEG10 (P<0.05). 25591808 Lnc2Cancer
EL1067 PICSAR testicular embryonal carcinoma microarray, qPCR, knockdown, Western blot, Northern blot, RIP, RNA pull-down assay etc. testicular tissue, cell lines(NTERA-2, NCCIT, HEK293 T cell) down-regulated interaction NLC1-C, also known as long intergenic non-protein-coding RNA162 (LINC00162), was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control. The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. 26539909 Lnc2Cancer
EL1068 Pinc breast cancer N/A N/A N/A N/A In a finding of relevance to breast cancer pathogenesis, the mammary gland lncRNA PINC, whose genomic structure is substantially different between primates and rodents has been shown to function in both cell survival and cell cycle progression. 20951849 LncRNADisease
EL1069 Pinci1-1 late blight Suppression subtractive hybridization (SSH),Real-time RT-PCR N/A N/A N/A N/A 17322195
EL1070 PINK1-AS Parkinson's disease N/A N/A N/A Interaction Mutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. Welective targeting of naPINK1 results in loss of the PINK1 splice variant in neuronal cell lines. 17362513 LncRNADisease
EL1070 PINK1-AS glucose metabolism disorder N/A N/A N/A expression As the name suggests, PINK1 is induced by PTEN, which is an important inhibitor of insulin signalling. PINK1 depletion has been associated with diabetes status, impaired glucose uptake in neuronal cell lines and with mitochondrial gene expression in adipocytes , raising the possibility that disruption to naPINK1 may impact on glucose metabolism. 22817756 LncRNADisease
EL1071 PISRT1 blepharophimosis syndrome N/A N/A N/A mutation The blepharophimosis syndrome (BPES) is driven by dysregulation of the FOXL2 gene, numerous extragenic mutations have been reported in patients. One particular deletion occurring 283 kb away from FOXL2 disrupts a lncRNA, PISRT1, that was shown by chromatin confirmation capture to physically loop with FOXL2. 20930520 LncRNADisease
EL1073 PLEC chronic obstructive pulmonary disease Agilent Human lncRNA + mRNA Array v2.0 system lung tissue of smokers with COPD down-regulated expression N/A 25542208
EL1074 PMS2P5 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL1076 POT1-AS1 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL1077 linc-POU3F3 glioma qPCR etc. glioma tissue, cell lines (T98G, A172) up-regulated N/A By using real-time PCR and gain-/loss-of-function studies,the authors revealed that linc-POU3F3 levels were extraordinarily associated with the tumor WHO grade.In related biochemical assays, overexpression of linc-POU3F3 promotes cell viability and proliferation in glioma cells, whereas knockdown of linc-POU3F3 showed the opposite effect. As expected, they also found that linc-POU3F3 expression was negatively correlated with the mRNA level of POU3F3. 25445282 LncRNADisease Lnc2Cancer
EL1077 linc-POU3F3 esophageal squamous cell carcinoma qPCR etc. blood (plasma and serum) up-regulated expression Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. 25608466 Lnc2Cancer
EL1077 linc-POU3F3 esophageal squamous cell carcinoma qPCR, Western blot, Luciferase reporter assay, RIP etc. ESCC tissue up-regulated N/A Levels of a lincRNA encoded by a gene located next to POU3F3 (linc-POU3F3) were significantly higher in ESCC than neighboring nontumor tissues. In RNA immunoprecipitation assays, linc-POU3F3 was associated with the EZH2 messenger RNA (mRNA). Overexpression of linc-POU3F3 in cell lines increased their proliferation and ability to form colonies, and reduced the expression of POU3F3 mRNA, whereas knockdown of linc-POU3F3 increased the levels of POU3F3 mRNA. 24631494 Lnc2Cancer
EL1078 POU5F1P4 prostate cancer qPCR etc. prostate cancer tissue up-regulated N/A POU5F1P1 was found to be the only member of the POU5F1 family to be expressed in prostate with over-expression in prostatic carcinoma compared to surrounding prostatic tissue probably because of an increased density of expressing cells. The probability of a positive repeat biopsy increases with rising PCA3 scores. The PCA3 score was superior to %fPSA for predicting repeat prostate biopsy outcome and may be indicative of clinical stage and significance of pCa. 20017164 Lnc2Cancer
EL1079 POU6F2-AS2 oesophageal squamous cell carcinoma N/A N/A N/A N/A DNA damage response and regulates cells survival after ionizing radiation 27033944
EL1081 PPP3CB pancreatic ductal adenocarcinoma microarray, qPCR etc. cell line (MIA PaCa-2 ) up-regulated expression Differential expression 22078386 LncRNADisease Lnc2Cancer
EL1082 PRAL hepatocelluar carcinoma qPCR, Western blot etc. hepatocellular carcinoma tissues down-regulated interaction We found that lncRNA-PRAL could inhibit HCC growth and induce apoptosis in vivo and in vitro through p53. Subsequent investigations indicated that the three stem-loop motifs at the 5' end of lncRNA-PRAL facilitated the combination of HSP90 and p53, and thus competitively inhibited the MDM2-dependent p53 ubiquitination, resulting in the enhanced p53 stability. Additionally, in vivo lncRNA-PRAL delivery efficiently reduced the intrinsic tumors, indicating its potential therapeutic application. 26663434 Lnc2Cancer
EL1083 PRAS colon cancer qPCR etc. cell lines (SNU-C4R, SNU-C5R etc.) down-regulated N/A We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. 25078450 Lnc2Cancer
EL1085 PRINS prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1085 PRINS psoriasis N/A N/A N/A N/A PRINS is a psoriasis susceptibility-related noncoding RNA gene. 15855153 LncRNADisease
EL1085 PRINS psoriasis N/A N/A N/A expression The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. 20377629 LncRNADisease
EL1085 PRINS psoriasis N/A N/A N/A expression In an effort to identify novel susceptibility factors for the hyperproliferative skin disorder psoriasis, Sonkoly et al. analyzed differential gene expression of unaffected epidermis from psoriasis patients compared to specimens from healthy subjects and identified a novel lncRNA called psoriasis susceptibility-related RNA gene induced by stress (PRINS) involved in psoriasis susceptibility 24115003 LncRNADisease
EL1085 PRINS psoriasis silenced with small interfering RNA (siRNA) normal human keratinocytes (NHKs) and HaCaT cells N/A N/A PRINS expression responded differentially to various stress signals and microbial agents in HaCaT cells and in NHKs: after translational inhibition and UV-B treatment, similar induction of PRINS expression occurred with different time courses while after microbial agent treatment, the PRINS expression was significantly induced in HaCaT cells, whereas we could not detect similar changes in NHKs. Silencing of PRINS had no effect on LPS-induced NF-κB activity either in HaCaT cells or in NHKs PRINS probably affects keratinocytes functions independently of NF-κB signalling 21750967
EL1086 Prion-associated RNAs prion disease N/A N/A N/A expression Host-encoded stimulatory rna molecules may have a role in the pathogenesis of prion disease. 14562104
EL1088 PRNCR1 prostate cancer N/A N/A N/A regulation That same year, Chung et al reported PCa susceptibility SNPs within a 13 kb intron-less lincRNA also on 8q24, which they termed PRNCR1. 24146262 LncRNADisease
EL1088 PRNCR1 prostate cancer N/A N/A N/A regulation Susceptibility marker oncogene 24373479 LncRNADisease
EL1088 PRNCR1 prostate cancer N/A N/A N/A regulation The focus of this Nature report13 is on two PCa-associated lncRNAs: PCGEM1 and PRNCR1. They cooperate in regulating the function of the male hormone receptor, the androgen receptor (AR), which plays central role in PCa onset and progression. AR pathway is activated in advanced CaPs including castration-resistant prostate cancer (CRPC). 24713835 LncRNADisease
EL1088 PRNCR1 colorectal cancer PCR-RFLP etc. CRC tissue differential expression N/A In overall analyses, we found that the rs13252298 and rs1456315 were associated with significantly decreased risks of CRC. In stratification analyses, we found that CRC patients carrying the rs1456315G were likely to have a tumor size of greater than 5 cm (G vs. A: adjusted OR = 1.56, 95% CI: 1.10-2.23). Additionally, patients with the rs7007694C and rs16901946G had decreased risks to develop poorly differentiated CRC, whereas patients with the rs1456315G had an increased risk to develop poorly differentiated CRC. 24330491 Lnc2Cancer
EL1088 PRNCR1 gastric cancer qPCR etc. gastric cancer tissue differential expression mutation We found that patients with the rs13252298AG genotype displayed a 1.50-fold increased risk of GC. Interestingly, the rs7007694CT and CC and the rs1456315GG genotypes displayed a decreased risk of GC. Our results suggest that SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC 26206497 Lnc2Cancer
EL1088 PRNCR1 colorectal cancer qPCR, Flow cytometry assay etc. CRC tissue, cell lines (SW620, HCT116, SW480, LoVo, HT29) up-regulated expression PRNCR1 was significantly overexpressed in CRC tissues compared with the expression in adjacent tissues, with an average fold increase of 10.55. Additionally, a high level of PRNCR1 was associated with large tumor volume. Compared with the normal human colorectal epithelial cell line (FHC), PRNCR1 was upregulated in most CRC cell lines (HCT116, SW480, LoVo and HT 29). 26530130 Lnc2Cancer
EL1088 PRNCR1 prostate cancer qPCR, Northern blot etc. cell lines (LNCaP, 22Rv1, PC-3 etc.) up-regulated N/A PRNCR1 expression was upregulated in some of the PC cells as well as precursor lesion prostatic intraepithelial neoplasia. Knockdown of PRNCR1 by siRNA attenuated the viability of PC cells and the transactivation activity of androgen receptor, which indicates that PRNCR1 could be involved in prostate carcinogenesis possibly through androgen receptor activity. 20874843 Lnc2Cancer
EL1088 PRNCR1 prostate cancer qPCR, RIP etc. prostate cancer tissue,cell lines (LNCaP, LNCaP-cds1, LNCaP-cds2, CWR22Rv1 etc.), tissues (prostate tumour tissues) up-regulated expression Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. 23945587 LncRNADisease Lnc2Cancer
EL1088 PRNCR1 prostate cancer RNA-seq, qRT-PCR N/A N/A N/A not implicated in castration resistant prostate cancer. 24727738
EL1089 PRR26 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL1090 PRSS21 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1092 PSORS1C3 psoriasis N/A N/A N/A N/A Psoriasis susceptibility 1 candidate 3 15848982 LncRNADisease
EL1092 PSORS1C3 psoriasis N/A N/A N/A mutation The PSORS1C3*582A allele, an SNP in the 3'-untranslated region of the PSORS1C3 gene, was a major psoriasis vulgaris susceptibility allele in the Chinese population, and the association was much stronger in patients with early-onset psoriasis vulgaris. 16965413 LncRNADisease
EL1094 PTCSC1 papillary thyroid carcinoma qPCR etc. PTA tissue tissue up-regulated expression Gene expression analysis indicated that AK023948 is significantly down-regulated in most PTC tumors. The putative noncoding RNA gene AK023948 is a candidate susceptibility gene for PTC. 19147577 LncRNADisease Lnc2Cancer
EL1095 PTCSC2 papillary thyroid carcinoma microarray, qPCR etc. PTC tissue, blood down-regulated expression Transcripts of PTCSC2 are down-regulated in PTC tumors. We also observed a significant association of age and CLT with PTCSC2 unspliced transcript levels.Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of non-coding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer. 25303483 Lnc2Cancer
EL1096 PTCSC3 papillary thyroid carcinoma microarray, qPCR, Western blot etc. thyroid cancer tissue, cell line (TPC-1) up-regulated interaction Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue, and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF and MMP-9 were suppressed in the presence of PTCSC3. PTC cells expressing PTCSC3 showed reduction in motility and invasiveness. 26274343 Lnc2Cancer
EL1096 PTCSC3 thyroid cancer microarray, qPCR, Western blot etc. thyroid tissue, cell lines (PTC) down-regulated expression Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue (r = 0.429, P = .0001), and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF, and MMP-9 were suppressed in the presence of PTCSC3 (P = .0051, P = .0090, and P =.0037, respectively). PTC cells expressing PTCSC3 showed reduction in motility and invasiveness 26274343 Lnc2Cancer
EL1096 PTCSC3 papillary thyroid carcinoma N/A N/A N/A mutation A thyroid-specific lncRNA, termed PTC susceptibility candidate 3 (PTCSC3), that was strongly downregulated in PTC was identified in this region and it was found that the repression was caused by the associated SNP. 23660942 LncRNADisease
EL1096 PTCSC3 papillary thyroid carcinoma N/A N/A N/A expression The study showed that the expression of PTCSC3 in six thyroid cancer cell lines is lower and no expression was detected in any of them.? 24817925 LncRNADisease
EL1096 PTCSC3 thyroid cancer qPCR etc. thyroid cancer tissue, cell lines (BCPAP, FTC133, 8505C etc.) differential expression N/A Following transfection with PTCSC3, all three thyroid cancer cells originating from various pathological types of thyroid cancers demonstrated significant growth inhibition, cell cycle arrest and increased apoptosis. So PTCSC3 as a tumor suppressor was investigated as a competing endogenous RNA for miR-574-5p. 23599737 Lnc2Cancer
EL1096 PTCSC3 papillary thyroid carcinoma qPCR, knockdown, RIP, FCA etc. PTC tissue, cell line (IHH-4) down-regulated expression The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. 26323637 Lnc2Cancer
EL1097 PTENP1 tumor N/A N/A N/A regulation An example of this mechanism is represented by the tumour suppressor gene PTEN and its pseudogene PTENP1. 23660942 LncRNADisease
EL1097 PTENP1 prostate cancer N/A N/A N/A regulation Oncogene; tumour suppressor 24373479 LncRNADisease
EL1097 PTENP1 cancer N/A N/A N/A regulation PTENP1 pseudogene belongs to the group of competing endogenous RNAs (ceRNAs). It may act as “decoy” by protecting PTEN mRNA from binding to common miRNA and therefore allowing expression of the tumor suppressor protein.? 24757675 LncRNADisease
EL1097 PTENP1 gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. 25694351 Lnc2Cancer
EL1097 PTENP1 hepatocelluar carcinoma qPCR, Western blot etc. HCC cell lines down-regulated expression Here we confirmed that PTENP1 and PTEN were downregulated in several HCC cells.These data colletcively unveiled the molecular mechanisms of how PTENP1 repressed the tumorigenic properties of HCC cells and demonstrated the potential of the SB-BV hybrid vetcor for PTENP1 lncRNA modulation and HCC therapy.PTENP1 repressed the tumorigenic properties of HCC cells and demonstrated the potential of the SB-BV hybrid vector for PTENP1 lncRNA modulation and HCC therapy. 25617127 Lnc2Cancer
EL1098 PTENP1-AS tumor N/A N/A N/A regulation We characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. We find two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, localizes to the PTEN promoter and epigenetically modulates PTEN transcription by the recruitment of DNA methyltransferase 3a and Enhancer of Zeste. In contrast, the β isoform interacts with PTENpg1 through an RNA-RNA pairing interaction, which affects PTEN protein output through changes of PTENpg1 stability and microRNA sponge activity. 23435381 LncRNADisease
EL1100 PTHLH brachydactyly N/A N/A N/A expression Silencing of the lncRNA, PTHLH, or SOX9 revealed a feedback mechanism involving an expression-dependent network in humans. In the BDE patients, the human lncRNA was upregulated by the disrupted chromosomal association. 23093776 LncRNADisease
EL1102 PVT1 acute promyelocytic leukemia knockdown peripheral blood cells from 28 patients with de novo APL up-regulated interaction Significantly lower MYC and PVT1 expression was observed during all-trans retinoic acid (ATRA)-induced differentiation and cell cycle arrest in the APL cell line. MYC knockdown in NB4 cells led to PVT1 downregulation. Moreover, PVT1 knockdown by RNA interference led to suppression of the MYC protein level, and cell proliferation was inhibited. 26544536
EL1102 PVT1 non-small cell lung cancer knockdown of PVT1 inhibited NSCLC cell proliferation and induced apoptosis both in vitro and in vivo 105 human NSCLC tissues up-regulated N/A High expression of PVT1 was associated with a higher TNM stage and tumor size 26908628
EL1102 PVT1 gastric cancer microarray, qPCR etc. gastric cancer tissues, cell lines (SGC7901) up-regulated expression PVT1 showed higher expression in human gastric cancer tissues than in adjacent non-cancerous tissues and in SGC7901 paclitaxel-resistant cells compared with SGC7901 cells. PVT1 expression was correlated with lymph node invasion of gastric cancer. 25258543 Lnc2Cancer
EL1102 PVT1 malignant pleural mesothelioma microarray, qPCR, knockdown etc. MPM tissue, MPM cell lines up-regulated N/A Our results suggest that C-MYC and PVT1 CNG promotes a malignant phenotype of MPM, with C-MYC CNG stimulating cell proliferation and PVT1 both stimulating proliferation and inhibiting apoptosis. 24926545 Lnc2Cancer
EL1102 PVT1 colorectal cancer microarray, qPCR, Western blot, knockdown etc. CRC tissue, cell lines (RKO, HCT116 etc.) up-regulated N/A CRC cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGFβ1 signalling pathway and apoptotic signals were significantly activated. In addition, univariate and multivariate analysis revealed that PVT-1 expression level was an independent risk factor for overall survival of colorectal cancer patients. 24196785 Lnc2Cancer
EL1102 PVT1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1102 PVT1 type 2 diabetes mellitus N/A N/A N/A mutation Identification of PVT1 (rs2720709, A>G) as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. 17395743 LncRNADisease
EL1102 PVT1 Burkitt's lymphoma N/A N/A N/A mutation PVT1 is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. 17503467 LncRNADisease
EL1102 PVT1 murine plasmacytomas N/A N/A N/A mutation PVT1 is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. 17503467 LncRNADisease
EL1102 PVT1 renal cancer N/A N/A N/A mutation Variants (rs13447075, A>C;rs2648862, A>C) in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes. 17881614 LncRNADisease
EL1102 PVT1 cleft lip N/A N/A N/A mutation Association identified by GWAS (rs987525,A>G). 19270707 LncRNADisease
EL1102 PVT1 Hodgkin's lymphoma N/A N/A N/A N/A PVT1 is a new susceptibility loci for this disease. 21037568 LncRNADisease
EL1102 PVT1 type 1 diabetes mellitus N/A N/A N/A mutation There is association between variants (rs2720709, A>G) in the plasmacytoma variant translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1 and type 2 diabetes. 21526116 LncRNADisease
EL1102 PVT1 type 2 diabetes mellitus N/A N/A N/A mutation There is association between variants (rs2720709, A>G) in the plasmacytoma variant translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1 and type 2 diabetes. 21526116 LncRNADisease
EL1102 PVT1 diabetic nephropathy N/A N/A N/A Interaction PVT1 may mediate the development and progression of diabetic nephropathy through mechanisms involving ECM accumulation. 21526116 LncRNADisease
EL1102 PVT1 diabetic nephropathy N/A N/A N/A regulation Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy. 24204837 LncRNADisease
EL1102 PVT1 lymphoma N/A N/A N/A N/A Burkitt lymphoma association 2470097 LncRNADisease
EL1102 PVT1 cancer N/A N/A N/A N/A A single supernumerary segment encompassing all four genes(Myc gene or the region encompassing Pvt1, Ccdc26 and Gsdmc ) successfully promotes cancer; PVT1 RNA and MYC protein expression correlated in primary human tumours, and copy number of PVT1 was co-increased in more than 98% of MYC-copy-increase cancers. 25043044 LncRNADisease
EL1102 PVT1 cancer N/A N/A N/A expression The PVT gene frequently amplifies with MYC in tumor cells. 2725491 LncRNADisease
EL1102 PVT1 lymphoma N/A N/A N/A N/A Burkitt lymphoma association 3024964 LncRNADisease
EL1102 PVT1 breast cancer qPCR etc. cell lines (A2780, DOV13, PA-1 etc.) up-regulated expression Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. 17908964 LncRNADisease Lnc2Cancer
EL1102 PVT1 ovarian cancer qPCR etc. cell lines (A2780, DOV13, PA-1 etc.) up-regulated expression Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. 17908964 LncRNADisease Lnc2Cancer
EL1102 PVT1 pancreatic cancer qPCR etc. cell line (ASPC-1) up-regulated expression PVT1 gene as a regulator of Gemcitabine sensitivity and showed that functional inactivation of the PVT1 gene led to enhanced Gemcitabine sensitivity in human pancreatic cancer ASPC-1 cells. 21316338 LncRNADisease Lnc2Cancer
EL1102 PVT1 breast cancer qPCR etc. breast cancer tissue, cell lines (BRF71T1, HCC38, HCC1143 etc.) up-regulated N/A In the 43 breast cancer tissues, PVT1 expression was significantly higher in those with the GG genotype than that in the GA or AA genotype. Compared to normal tissues with any of the genotypes, PVT1 expression was also higher in the tumors with the GG genotype. These findings suggest that the GG genotype of SNP rs13281615 influences breast cancer development likely by modulating PVT1 expression. 24780616 Lnc2Cancer
EL1102 PVT1 hepatocelluar carcinoma qPCR etc. cell lines (HepG2, LM3, SMMC-7721) up-regulated N/A Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2 25043274 LncRNADisease Lnc2Cancer
EL1102 PVT1 hepatocelluar carcinoma qPCR etc. HCC tissue, cell lines (Huh7, SK-hep1, SMMC-7721, HepG2, Hep3B, PLC/PRF/5, Bel-7402) up-regulated expression The relative expression levels of PVT1 were significantly higher in cancerous tissues compared with the corresponding non-cancerous tissues. Furthermore, overexpression of PVT1 was associated with a higher serum a-fetoprotein expression level and a higher recurrence rate. Kaplan-Meier analysis indicated that the patients with high PVT1 expression exhibited poor recurrence-free survival, and multivariate analysis demonstrated that high levels of PVT1 expression are an independent predictor for HCC recurrence. 25624916 Lnc2Cancer
EL1102 PVT1 pancreatic ductal adenocarcinoma qPCR etc. PDAC tissue up-regulated expression The study results showed that the PVT1 expression was significantly increased in PDAC tissues compared to adjacent nontumor tissues. The expression of PVT1 was associated with clinical stage and N-classification (P<0.05). Patients with high PVT1 expression level had shorter overall survival times compared to those with low PVT1 expression level (P<0.05). 25668599 Lnc2Cancer
EL1102 PVT1 gastric cancer qPCR etc. gastric cancer tissue, cell lines(AGS, MKN45, 7901 etc.) up-regulated expression All the 8 lncRNAs were then subjected to qPCR validation using 20 pairs of GC and control tissues. Among them, HOTAIR, PVT1, H19, MALAT1, GHET1 and HULC were significantly higher in tumor tissues compared with control tissues. 26096073 Lnc2Cancer
EL1102 PVT1 prostate cancer qPCR, ChIP etc. cell lines (PC3, 1542-CP) differential expression mutation The risk allele (G) of rs378854 (A>G) reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected. 21814516 LncRNADisease Lnc2Cancer
EL1102 PVT1 multiple myeloma qPCR, FISH etc. cell lines (AMU-MM1, KMS-12-BM, KMS-18, KMS-20 etc.) differential expression N/A PVT1 rearrangements were most common and found in 7 of 12 patients (58.3%) and 5 of 8 cell lines (62.5%) with 8q24 abnormalities. A combination of spectral karyotyping (SKY), FISH, and oligonucleotide array identified several partner loci of PVT1 rearrangements, such as 4p16, 4q13, 13q13, 14q32, and 16q23-24. The PVT1-NBEA chimera in which PVT1 exon 1 was fused to NBEA exon 2 and the PVT1-WWOX in which PVT1 exon 1 was fused to WWOX exon 9 were associated with the expression of abnormal NBEA and WWOX lacking their N-terminus, respectively. These findings suggest that PVT1 rearrangements may represent a novel molecular paradigm underlying the pathology of 8q24 rearrangement-positive multiple myeloma. 22869583 Lnc2Cancer
EL1102 PVT1 non-small cell lung cancer qPCR, knockdown etc. NSCLC tissue, cell lines (A549, H157, HEK-293T) up-regulated expression lncRNA PVT1 expression was significantly upregulated in NSCLC tissues and lung cancer cells. Increased PVT1 expression was significantly correlated with histological grade and lymph node metastasis. In addition, NSCLC patients with PVT1 higher expression have shown significantly poorer overall survival than those with lower PVT1 expression. In vitro assays our results indicated that knockdown of PVT1 inhibited cell proliferation, migration, and invasion. 25400777 Lnc2Cancer
EL1102 PVT1 bladder cancer qPCR, knockdown, Flow cytometry assay etc. bladder cancer tissue, cell lines (T24, 5637) up-regulated expression Here, we found that PVT1 was upregulated in bladder cancer tissues and cells. Further experiments revealed that PVT1 promoted cell proliferation and suppressed cell apoptosis. 26517688 Lnc2Cancer
EL1102 PVT1 gastric cancer qPCR, Western blot etc. gastric cancer tissue, cell lines (BGC823, SGC7901 etc.) up-regulated N/A Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance 25956062 LncRNADisease Lnc2Cancer
EL1102 PVT1 non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC lines (A549, H157, H226, H460, HCC827) up-regulated expression Our results indicated that PVT1 expression was significantly increased in NSCLC tissues and cell lines, and its upregulation was associated with advanced T-stage and tumor-node-metastasis (TNM) stage and regional lymph node metastasis. PVT1 expression levels were robust in differentiating NSCLC tissues from controls 26493997 Lnc2Cancer
EL1102 PVT1 thyroid cancer qPCR, Western blot, RIP, ChIP etc. thyroid cancer tissues, cell lines (IHH-4, FTC-133, 8505C) up-regulated interaction Compared to the controls, lncRNA PVT1 was significantly up-regulated in thyroid tissues, as well as in three kinds of tumor cell lines (P < 0.05). Silenced PVT1 significantly inhibited thyroid cell line IHH-4, FTC-133, and 8505C cell proliferation and arrested cell cycle at G0/G1 stage and significantly decreased cyclin D1 and TSHR expressions (P < 0.05). Moreover, lncRNA PVT1 could be enriched by EZH2, and silencing PVT1 resulted in the decreased recruitment of EZH2 26427660 Lnc2Cancer
EL1102 PVT1 ovarian cancer qRT-PCR ovarian cancer tissues of cisplatin-resistant patients and cisplatin-sensitive patients up-regulated N/A Overexpression of LncRNA PVT1 in ovarian cancer promotes cisplatin resistance by regulating apoptotic pathways 26884974
EL1102 PVT1 gastric cancer QRT-PCR assay 111pairs of gastric cancer and adjacent normal tissues up-regulated N/A up-regulation was significantly correlated to invasion depth and regional lymph nodes metastasis 26925791
EL1102 PVT1 gastric cancer qRT-PCR, MTT and colony formation assays, RIP GC tissues and cell lines up-regulated expression The higher expression of PVT1 was significantly correlated with deeper invasion depth and advanced TNM stage. Further experiments demonstrated that PVT1 knockdown significantly inhibited the proliferation both in vitro and in vivo. These results suggest that lncRNA PVT1 may serve as a candidate prognostic biomarker and target for new therapies in human gastric cancer. 25890171
EL1104 R05532 colorectal cancer microarray, qPCR etc. cell lines (T29, SW480, RKO, Lovo, HCTll6) differential expression expression The radiosensitivity order of these 5 cell lines from low to high (SF2 value from high to low) was HT29, SW480, RKO, Lovo, HCT116. Among them, expression levels of R05532, NR_015441 and NR_033374 were positively correlated with radiation resistance(all P<0.01),which may be used as the predictiv marker of radiosensitivity of coloretcal cancer cells. 25421768 Lnc2Cancer
EL1105 RAB4B-EGLN2 cancer Genotype-phenotype correlation studies N/A N/A N/A overexpressing RERT-lncRNA upregulated EGLN2 23026137
EL1106 RAD1 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL1107 RAD51-AS1 breast cancer over-expression Hela cells up-regulated locus Our results identify TPIP as a novel E2F1 co-activator, suggest a similar role for other TPTEs, and indicate that the TODRA lncRNA affects RAD51 dysregulation and RAD51-dependent DSB repair in malignancy . Our results identify TPIP as a novel E2F1 co-activator, suggest a similar role for other TPTEs, and indicate that the TODRA lncRNA affects RAD51 dysregulation and RAD51-dependent DSB repair in malignancy. 26230935
EL1109 RBM5-AS1 tumour Northern blot analyses,PCR N/A up-regulated interaction Je2, which mapped to the antisense strand of intron 6 of the putative tumour suppressor gene RBM5/LUCA-15/H37, and functioned as an apoptosis suppressor. 19559772
EL1110 RCCRT1 renal cell carcinoma qPCR, knockdown etc. RCC tissue, cell lines (ACHN, A498) up-regulated expression Compared with adjacent noncancerous tissues, RCCRT1 is upregulated remarkably in RCC, particularly in high-grade RCC tissues. RCCRT1 is associated with clinicopathologic findings such as tumor size, pathologic T stage, tumor grade, lymph node metastasis, and distant metastasis. 25168566 Lnc2Cancer
EL1113 REST/CoREST-regulated lncRNAs Huntington's disease N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL1114 RGMB-AS1 lung cancer In vivo experiments lung adenocarcinoma cells up-regulated N/A lncRNA RGMB-AS1 downregulation significantly suppressed the growth of lung adenocarcinoma 26950071
EL1114 RGMB-AS1 non-small cell lung cancer microarray, qPCR, Western blot etc. NSCLC tissue, cell lines (A549 and SPC-A-1) up-regulated interaction LncRNA RGMB-AS1 expression was significantly higher in NSCLC tissues than in adjacent normal tissues, lncRNA RGMB-AS1 and RGMB expression levels in NSCLC tissues were associated with the occurrence of differentiation status, lymph node metastases and TNM stage. Studies also indicated that lncRNA RGMB-AS1and RGMB were inversely correlated. 26055877 Lnc2Cancer
EL1119 RMST rhabdomyosarcoma qPCR, Northern blot etc. rhabdomyosarcoma tissue differential expression expression NCRMS (RMST) on chromosome 12q21 shows differential expression between rhabdomyosarcoma subtypes. 12082533 LncRNADisease Lnc2Cancer
EL1120 RN7SK cancer N/A N/A N/A Interaction Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. 22377309 LncRNADisease
EL1120 RN7SK AIDS N/A N/A N/A Interaction HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. 20471949 LncRNADisease
EL1120 RN7SK AIDS N/A N/A N/A Interaction Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. The human 7SK snRNA carries a TAR RNA-like Tat-binding element that is essential for the normal transcriptional regulatory function of 7SK questions the viability of HIV therapeutic approaches based on small drugs blocking the Tat-binding site of HIV TAR. 20976203 LncRNADisease
EL1120 RN7SK AIDS N/A N/A N/A Interaction The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. 21087998 LncRNADisease
EL1120 RN7SK AIDS N/A N/A N/A expression Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. 21098020 LncRNADisease
EL1120 RN7SK AIDS N/A N/A N/A Interaction The HIV-1 Tat protein also releases P-TEFb from the 7SK/HEXIM complex during viral infection to promote viral transcription and replication. 22377309 LncRNADisease
EL1120 RN7SK cardiac hypertrophy N/A N/A N/A Interaction Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. 22377309 LncRNADisease
EL1120 RN7SK gastric cancer N/A N/A N/A expression Transfection of an siRNA directed against LARP7 (anti-LARP7 siRNA) into non-neoplastic gastric epithelial cells decreased 7sk levels by 72% relative to a control siRNA (P<0.01). 22488152 LncRNADisease
EL1121 RN7SL1 Leishmania infection N/A N/A N/A expression Down-regulation of 7SL RNA expression and impairment of vesicular protein transport pathways by Leishmania infection of macrophages. 15955815 LncRNADisease
EL1121 RN7SL1 dermatomyositis N/A N/A N/A Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. 16142868 LncRNADisease
EL1121 RN7SL1 polymyositis N/A N/A N/A Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. 16142868 LncRNADisease
EL1121 RN7SL1 AIDS N/A N/A N/A Interaction 7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. 16489186 LncRNADisease
EL1121 RN7SL1 Leishmania infection N/A N/A N/A expression High-resolution melt analysis PCR (HRM PCR) for diagnosis of Old World Leishmania was developed using the 7SL RNA gene. Cutaneous leishmaniasis samples were analyzed. Sensitivity and specificity of HRM PCR were significantly better (P < 0.001) than those of internal transcribed spacer 1 PCR and similar to those of kinetoplast DNA PCR. 20392923 LncRNADisease
EL1121 RN7SL1 Leishmania infection N/A N/A N/A N/A The 7SL RNA PCR has proven useful for direct diagnosis of Old World leishmaniasis, especially when combined with the RBD assay for species identification. 20561310 LncRNADisease
EL1121 RN7SL1 Leishmania infection N/A N/A N/A N/A Leishmania 7SLRNA is an informative target for clinical and epidemiologic investigations of human leishmaniasis. 20856851 LncRNADisease
EL1121 RN7SL1 AIDS N/A N/A N/A N/A 7SL RNA binding is a conserved feature of human anti-HIV-1 cytidine deaminases. 20926562 LncRNADisease
EL1122 RNA polymerase III-dependent lncRNAs diffuse cerebral hypomyelination with cerebellar atrophy and hypoplasia of the corpus callosum N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL1123 RNA44121|UCSC-2000-3182 chronic obstructive pulmonary disease Agilent Human lncRNA + mRNA Array v2.0 system lung tissue of smokers with COPD up-regulated expression N/A 25542208
EL1124 RNA50010|UCSC-9199-1005 chronic obstructive pulmonary disease Agilent Human lncRNA + mRNA Array v2.0 system lung tissue of smokers without Chronic obstructive pulmonary disease (COPD) up-regulated expression N/A 25542208
EL1125 RNA58351|CombinedLit_316_550 chronic obstructive pulmonary disease Agilent Human lncRNA + mRNA Array v2.0 system lung tissue of non-smokers without COPD down-regulated expression N/A 25542208
EL1126 RNA-a Opitz–Kaveggia syndrome N/A N/A N/A regulation A recent study indicated that a subset of long ncRNAs, called activating long ncRNAs (RNA-a), is associated with Opitz–Kaveggia (also known as FG) syndrome, a X-linked intellectual disability syndrome, characterized by various neuronal pathologies as well as developmental abnormalities. 24624135 LncRNADisease
EL1127 RNase MRP Cartilage Hair Hypoplaisia N/A N/A N/A mutation Point mutations in RNase MRP cause human Cartilage Hair Hypoplaisia (CHH), and several disease-causing mutations map to RMRP-S1 and -S2. SHAPE chemical probing identified two alternative secondary structures altered by disease mutations. 24009312 LncRNADisease
EL1129 RNY1 bladder, cervix, colon, kidney, lung and prostate cancer quantitative RT-PCR,RNA interference human solid tumour,nonmalignant normal tissues up-regulated expression Degradation of hY1 and hY3 RNAs in human cell lines resulted in a significant cytostatic inhibition of cell proliferation. 18283318
EL1132 RP11-1008C21.2 non-small cell lung cancer cancer tissues compared to adjacent normal tissues cancer tissues compared to adjacent normal tissues down-regulated N/A overexpression suppressed the proliferation and migration in NSCLC cell lines in vitro 26883250
EL1133 RP11-119F7.4 gastric cancer qPCR etc. gastric cancer tissue down-regulated expression RP11-119F7.4 expression was significantly downregulated in the gastric cancer tissues compared with the matched NATs (P<0.001) and was significantly associated with the macroscopic type (P=0.041) and Lauren grade (P=0.020). LncRNA RP11-119F7.4 may be involved in carcinogenesis and may prove useful as a biomarker for diagnosis and prognostic significance in patients with gastric cancer. 26170986 Lnc2Cancer
EL1134 LOC102724601 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We discovered three lncRNA, RP11-160H22.5, XLOC_014172 and LOC149086, which were up-regulated in HCC comparing with the cancer-free controls. RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction and XLOC_014172 and LOC149086 for metastasis prediction in the future. 25714016 Lnc2Cancer
EL1135 LINC01537 laryngeal squamous cell carcinoma microarray, qPCR etc. LSCC tissue up-regulated expression AC026166.2-001 and RP11-169D4.1-001 were distinctly dysregulated, with AC026166.2-001 exhibiting lower expression in cancer tissues and RP11-169D4.1-001 higher expression. We verified that both AC026166.2-001 and RP11-169D4.1-001 were expressed at a lower level in cervical lymph nodes compared with paired laryngeal cancer tissues and paired normal tissues. RP11-169D4.1-001 levels were positively correlated with lymph node metastasis. 25243407 Lnc2Cancer
EL1136 LINC01513 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1137 RP11-284N8.3.1 ovarian cancer high-throughput molecular profiles 399 Ovarian cancer (OV) patients N/A expression Two protective lncRNAs, RP11-284N8.3.1 and AC104699.1.1, were not only differentially expressed throughout the progression of malignant OV but were also independently predictive of the survival of patients with different OV stages. A functional analysis of the two lncRNAs predicted their roles in immune system activation and other anti-tumor processes in the OV microenvironment. 26629053
EL1139 KCNMB2-AS1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression RP11-385J1.2 and TUBA4B were the most markedly changed of these candidate lncRNAs from 90 NSCLC and normal lung tissue samples. As shown in Fig. 4, RP11-385J1.2 expression in NSCLC was significantly higher than in the adjacent tissues, while TUBA4B expression in NSCLC was significantly lower than in the adjacent tissues. 25394782 Lnc2Cancer
EL1140 AC027031.2 endometrial cancer N/A endometrial cancer (EC) down-regulated expression Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. 26807189
EL1142 LINC01627 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue up-regulated expression We discovered that three lncRNAs (RP11-397D12.4, AC007403.1, and ERICH1-AS1) were up regulated in NSCLC, compared with cancer-free controls. RP11-397D12.4, AC007403.1, and ERICH1-AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future. 26393913 Lnc2Cancer
EL1143 RP11-401P9.4 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We found that the expression of 7 lncRNAs in preneoplastic lesions and HCC was significantly different. 26540467 Lnc2Cancer
EL1144 KCNK15-AS1 breast cancer qPCR etc. breast cancer tissue up-regulated expression In breast cancer patients, the expression level of lncRNA RP11-445H22.4 is significantly increased. Its expression levels were correlated with estrogen receptor (ER), progesterone receptor (PR), and menopausal status of the breast cancer patients (p < 0.05). 25929808 Lnc2Cancer
EL1145 AL355870.1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1147 AC108134.4 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1148 LINC00383 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) up-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. RP5- 1014O16.1 was highly expressed in high lymphatic metastatic potential HCC cell lines, while lowly expressed in no lymphatic metastatic potential HCC cell lines.We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL1149 AL138930.1 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1150 ZBTB20-AS4 pancreatic cancer microarray, qPCR etc. cell lines (SW1990, SWl990/GZ etc.) up-regulated expression Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). 25755691 Lnc2Cancer
EL1151 AC104590.1 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1152 AL133217.1 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) up-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL1154 LINC01612 gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated interaction The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1155 Z95152.1 nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) up-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294006) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
EL1156 LINC01969 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1157 AL020996.1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL1158 RP13-514E23.1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1159 RP1-90D4.3 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1160 AL021707.1 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL1161 AL109741.3 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1162 AL121845.1 breast cancer microarray, qPCR etc. breast cancer tissue up-regulated interaction RP4-583P15.10, an up-regulated lncRNA, was found to be located downstream of the natural antisense of the ZBTB46 gene, which may regulated breast cancer through influence immune system. 25661361 Lnc2Cancer
EL1163 RP4-620F22.3 enterovirus 71 infection N/A N/A N/A expression A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation 23220233 LncRNADisease
EL1164 AC244098.1 hepatocelluar carcinoma microarray, qPCR etc. cell lines (Hep3B, HepG2, SMMC-7721, MHCC-97L, MHCC-97H, HCCLM3 etc.) up-regulated expression The most upregulated lncRNAs in H2 were RP11-672F9.1, RP5-1014O16.1, and RP11-501G6.1, while the most downregulated ones were lincRNA-TSPAN8, lincRNA-CALCA, C14orf132, NCRNA00173, and CR613944. We demonstrated that a large number of lncRNAs may play important roles in driving HCC cells to metastasize to different sites; these lncRNAs may provide novel molecular biomarkers and offer a new basis for combating metastasis in HCC cases. 25556502 Lnc2Cancer
EL1165 AL445307.1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1166 RP5-833A20.1 atherosclerosis N/A N/A N/A N/A Using microarray analysis, the authors found that long noncoding RNA RP5-833A20.1 expression was upregulated, whereas nuclear factor IA (NFIA) expression was downregulated in human acute monocytic leukemia macrophage-derived foam cells. Moreover, they showed that long noncoding RNA RP5-833A20.1 maydecreases NFIA expression by inducing hsa-miR-382-5p expression in vitro. 25265644 LncRNADisease
EL1167 RP5-843L14.1 enterovirus 71 infection N/A N/A N/A expression A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation 23220233 LncRNADisease
EL1168 RPL34-AS1 colorectal cancer microarray, qPCR etc. CRC tissue down-regulated N/A We found that RP11-462C24.1 expression level was lower in cancer tissues compared with adjacent normal samples. Furthermore, its expression level was lower in CRC patients with metastasis than those without metastasis. That is, RP11-462C24.1 expression level decreased as the malignant degree of CRC increased. In addition, low expression of RP11-462C24.1 significantly correlated with more distant metastasis. 24908062 Lnc2Cancer
EL1168 RPL34-AS1 gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) down-regulated expression Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. 26237576 Lnc2Cancer
EL1169 RPLP0P2 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1171 RRP1B cancer N/A N/A N/A epigenetics RRP1B, a tumor progression and metastasis susceptibility candidate gene, is potentially a dynamic modulator of transcription and chromatin structure. 19710015 LncRNADisease
EL1171 RRP1B Spinocerebellar ataxia type 7 N/A N/A N/A expression CTCF is required for SCAANT1 expression. Loss of SCAANT1 derepressed ataxin-7 sense transcription in a cis-dependent fashion and was accompanied by chromatin remodeling. 21689595 LncRNADisease
EL1171 RRP1B Spinocerebellar ataxia type 7 N/A N/A N/A mutation For example, SCA7/ATXN7 antisense RNA 1 (SCAANT1) is an lncRNA transcribed antisense to the gene mutated in spinocerebellar ataxia type 7 (ATXN7), and it functions as a repressor of ATXN7 transcription 22814587 LncRNADisease
EL1171 RRP1B Spinocerebellar ataxia type 7 N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL1171 RRP1B Spinocerebellar ataxia type 7 N/A N/A N/A expression Long ncRNA SCAANT1 is implicated in a type of polyglutamine disorder, spinocerebellar ataxia type 7 (SCA7). 24624135 LncRNADisease
EL1171 RRP1B laryngeal squamous cell carcinoma qPCR etc. LSCC tissue down-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
EL1173 RUNX1 acute myeloid leukemia qPCR, RNA-ChIP etc. bone marrow, cell lines (KG-1, KG-1a, Kasumi-1, K562) up-regulated regulation RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancers and participates in the orchestration of an intrachromosomal loop. The 3' region of RUNXOR also participates in?long-range interchromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations. 24752773 LncRNADisease Lnc2Cancer
EL1174 RUNX1-IT1 gastric cancer microarray and quantitative real-time polymerase chain reaction (qRT-PCR), over-expression metastatic lymph node tissues and normal lymph node tissues up-regulated expression The expression levels of C21orF96 were associated with gross appearance, lymphatic metastasis and distal metastasis. C21orF96 promoted the tubular formation, migration and invasion. 26567621
EL1177 SAMMSON melanoma exogenous SAMMSON ; SAMMSON knockdown melanoma N/A N/A exogenous SAMMSON increases the clonogenic potential 27008969
EL1178 SARCC renal cell carcinoma a von Hippel-Lindau (VHL)-dependent manner both in RCC cell culture RCC cell culture and clinical specimens N/A N/A LncRNA-SARCC can post-transcriptionally regulate androgen receptor (AR) 26973243
EL1179 Scarb2 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 18 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL1180 SCHLAP1 prostate cancer microarray, ISH etc. prostate cancer tissue up-regulated N/A SChLAP1 expression increases with prostate cancer progression,and high SChLAP1 expression by ISH is associated with poor outcome after radical prostatectomy in patients with clinically localized prostate cancer by both univariate and multivariate Cox regression analyses. 25499224 LncRNADisease Lnc2Cancer
EL1180 SCHLAP1 prostate cancer microarray, qPCR etc. prostate cancer tissue up-regulated N/A The long non-coding RNA SChLAP1 was identified as the highest-ranked overexpressed gene in cancers with metastatic progression. 25456366 LncRNADisease Lnc2Cancer
EL1180 SCHLAP1 prostate cancer N/A N/A N/A expression Prensner et al found that the lncRNA SChLAP1 was overexpresed in prostate tumors and where it is critical for tumor cell metastasis. 24829860 LncRNADisease
EL1180 SCHLAP1 bladder cancer real-time qPCR Bladder cancer T24 and 5637 cells up-regulated N/A Cell growth arrest, apoptosis induction and migration inhibition 26861061
EL1180 SCHLAP1 prostate cancer RNA-Seq, qPCR, in vitro knockdown etc. prostate cancer tissue, prostate cell lines (PCAT-109, PCAT-114 etc.) up-regulated N/A SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex. 24076601 Lnc2Cancer
EL1181 Sema3g ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL1183 sfRNA Japanese encephalitis Northern blot and real-time RT-PCR, Transfection N/A down-regulated N/A sfRNA modulates viral translation and replication in trans. 22040380
EL1185 SGO1-AS1 Xuanwei lung cancer High throughput microarray assay, qRT-PCR Xuanwei lung cancer (XWLC) tissues N/A expression N/A 26642714
EL1206 SIRT1-AS hepatocelluar carcinoma qPCR, Western blot, Northern blot, knockdown etc. cell line (HCC-9903) up-regulated interaction SIRT1-AS overexpression promoted the proliferation of the human HCC cell lines by upregulating the SIRT1 protein level. The mechanism was that SIRT1-AS bound to SIRT1 mRNA at 3'UTR, masked the miR-29c binding site and stabilized SIRT1 mRNA. 26324025 Lnc2Cancer
EL1207 SIRT1-AS 622C mutation hepatocelluar carcinoma qPCR, Western blot, Northern blot, knockdown etc. cell line (HCC-9903) up-regulated mutation The mutation led to a marked alteration in the secondary structure of SIRT1-AS and caused its inability to bind with SIRT1 mRNA. 26324025 Lnc2Cancer
EL1209 SKP2 non-small cell lung cancer qPCR, Western blot etc. non-small cell lung cancer tissue, NSCLC cell lines(ATCC, Rockville, MD, USA) differential expression interaction These data suggest that the Skp2 may be regulated by Meg3 at post-transcriptional level. Bioinformatics analyses showed that miR-3163 bound to 3'-UTR of Skp2 mRNA in NSCLC cells to inhibit its translation, which was supported by luciferase reporter assay. Meg3 augmented the effects of miR-3163 on Skp2 mRNA, possibly through binding-induced function enhancement, which was supported by the double fluorescent in situ hybridization showing co-localized intracellular Meg3 and miR-3163 signals in NSCLC cells. The miR-3163 levels in NSCLC were not different from in NT, suggesting that the regulation of Skp2 in NSCLC by miR-3163 may require coordination of Meg3 26482610 Lnc2Cancer
EL1210 SLC25A25-AS1 colorectal cancer microarray, qPCR etc. cell lines (T29, SW480, RKO, Lovo, HCTll6) differential expression expression The radiosensitivity order of these 5 cell lines from low to high (SF2 value from high to low) was HT29, SW480, RKO, Lovo, HCT116. Among them, expression levels of R05532, NR_015441 and NR_033374 were positively correlated with radiation resistance(all P<0.01),which may be used as the predictiv marker of radiosensitivity of coloretcal cancer cells. 25421768 Lnc2Cancer
EL1212 SLC6A6 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL1213 SLC7A2-IT1A/B progressive encephalopathy with severe infantile anorexia N/A N/A N/A mutation Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 LncRNADisease
EL1214 SLCO5A1 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue up-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL1215 SMAD1-AS1 Ventricular septal defects N/A N/A N/A expression Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. 24147006 LncRNADisease
EL1216 Smad7 breast cancer RNA sequencing, small interfering RNA mouse mammary gland epithelial cell lines and breast cancer cell lines N/A interaction lncRNA-Smad7 has anti-apoptotic functions, as a target of TGF-β. 24863656
EL1218 SNAR-A1 colon cancer qPCR etc. cell lines (SNU-C4R, SNU-C5R etc.) down-regulated interaction We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. 25078450 Lnc2Cancer
EL1219 SNCG gastric cancer microarray, qPCR, in vitro knockdown etc. gastric cancer tissue, cell lines (SGC7901, MKN45, MKN28) up-regulated regulation AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. Next, we identified γ-synuclein. (SNCG), which is a metastasis-related gene regulated by AK058003. In addition, we found that the expression of SNCG is positively correlated with that of AK058003 in the clinical GC samples used in our study. Furthermore, we found that the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis. 25499222 Lnc2Cancer
EL1220 SNED1 Idiopathic pulmonary fibrosis overexpression human lung epithelial cells up-regulated expression Overexpression of uc.77 or 2700086A05Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. 26824344
EL1221 SNHG1 non-small cell lung cancer qPCR, knockdown etc. cell lines (NL9980, L9981, A549, H1299, H460, SK-MES-1 etc.) up-regulated expression Noncoding RNA SNHG1 expression was significantly upregulated in lung cancer cells when compared with normal bronchial epithelial cells. In addition, in vitro assays our results indicated that knockdown of SNHG1 inhibited cell proliferation. 25818744 Lnc2Cancer
EL1222 SNHG11 obesity N/A N/A N/A mutation New gene associated with obesity. 20532202 LncRNADisease
EL1223 SNHG12 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue up-regulated expression ASLNC04080 was the most significantly upregulated lncRNA in microarray data, highly expressed in 22 out of 24 endometrial carcinoma tissues and HEC-1-B cell line. Moreover, the ASLNC04080 lncRNA expression was correlated with 19 coding genes, and may contribute to endometrial carcinoma genesis and progression by co-regulating with coding gene. Expression inhibition of lncRNA ASLNC04080 in HEC-1-B cells caused repression of cell proliferation, increased cell apoptosis, and G1 phase arrest. 25695231 Lnc2Cancer
EL1223 SNHG12 osteosarcoma western blot, quantitative real-time polymerase chain reaction, RNA interference, cell migration assays, flow cytometry primary osteosarcoma (n = 20) and adjacent normal tissues (n = 20), the osteosarcoma cell lines, SAOS-2, MG-63, U-2 OS, and the human osteoblast cell line hFOB (OB3) up-regulated interaction Upregulation of AMOT mRNA was associated with upregulation of SNHG12. Knockdown of SNHG12 reduced the expression of angiomotin in osteosarcoma cells and suppressed cell proliferation and migration but did not affect cell apoptosis. The lncRNA SNHG12 promotes cell proliferation and migration by upregulating AMOT gene expression in osteosarcoma cells in vivo and in vitro. 26486328
EL1224 SNHG14 Angelman syndrome N/A N/A N/A locus Ube3a-as is a lncRNA transcribed antisense to the maternally expressed Ube3a gene, a candidate gene for AS, suggesting that Ube3a-as may be responsible for repressing paternal Ube3a expression. 20380817 LncRNADisease
EL1224 SNHG14 Angelman syndrome N/A N/A N/A regulation LncRNAs are also associated with imprinting disorders, such as ubiquitin protein ligase E3A (UBE3A)-ATS in Angelman syndrome. 23562612 LncRNADisease
EL1224 SNHG14 Angelman syndrome N/A N/A N/A expression Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A 23781896 LncRNADisease
EL1224 SNHG14 Prader-Willi syndrome N/A N/A N/A expression Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A 23781896 LncRNADisease
EL1224 SNHG14 Angelman syndrome N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL1224 SNHG14 Angelman syndrome N/A N/A N/A mutation Although in the majority of human tissues, both copies of the UBE3A gene are expressed, in neurons one copy is silenced by UBE3A-AS1 (ubiquitin-protein ligase E3A antisense RNA 1). In patients suffering from Angelman syndrome, the other (active) allele has either been deleted or inactivated. 24667321 LncRNADisease
EL1225 SNHG15 gastric cancer qPCR, Western blot, knockdown etc. gastric adenocarcinoma cancer cell lines (SGC7901, BGC823, MGC803, AGS, MKN45, GES-1) up-regulated interaction We identified a novel lncRNA SNHG15, whose expression was upregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, increased SNHG15 expression was positively correlated with invasion depth (P < 0.001), advanced tumor node metastasis (TNM) stage (P = 0.001), and lymph node metastasis (P = 0.019). SNHG15 levels were robust in differentiating GC tissues from controls (area under the curve (AUC) = 0.722; 95 % confidence interval (CI) = 0.657-0.782, P < 0.01). Kaplan-Meier analysis demonstrated that elevated SNHG15 expression contributed to poor overall survival (P < 0.01) and disease-free survival (P < 0.01) of patients. A multivariate survival analysis also indicated that SNHG15 could be an independent prognostic marker. Furthermore, knockdown of SNHG15 expression by siRNA could inhibit cell proliferation and invasion and induce apoptosis, while ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression 26662309 Lnc2Cancer
EL1226 SNHG16 neuroblastoma N/A N/A N/A regulation It is now becoming increasingly evident that N-myc also regulates the expression of long noncoding RNAs such as T-UCRs and ncRAN. 22936790 LncRNADisease
EL1226 SNHG16 bladder cancer N/A N/A N/A regulation putative diagnostic, prognostic, and predictive marker 24373479 LncRNADisease
EL1226 SNHG16 bladder cancer qPCR etc. bladder cancer tissue, cell lines (RT4, T24, J82 etc.) up-regulated N/A Expression of ncRAN was significantly higher in bladder cancers compared with normal tissues and in invasive tumor compared with superficial ones (P < .01). Consistently, ncRAN expressed significantly higher in invasive bladder tumor cell lines (5637, T24, J82) than that in superficial tumor cell line (RT4). Overexpression of ncRAN in RT4 cells significantly enhanced cell proliferation, migration, and invasion. Silencing of ncRAN improved chemotherapy sensitivity in 5637 cells. 21147498 Lnc2Cancer
EL1226 SNHG16 colorectal cancer qPCR, knockdown etc. CRC tissue, cell lines (LoVo, Caco-2, DLD1, SW620, SW480, HCT8, HCT116 etc.) down-regulated expression Down-regulation of ncRAN, a long non-coding RNA, contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients. 24519959 LncRNADisease Lnc2Cancer
EL1227 SNHG19 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We found that the expression of 7 lncRNAs in preneoplastic lesions and HCC was significantly different. 26540467 Lnc2Cancer
EL1228 SNHG3 Alzheimer's disease N/A N/A N/A expression We selected three differential signature genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage. 21961160 LncRNADisease
EL1228 SNHG3 hepatocelluar carcinoma RNA-seq, qPCR, ISH etc. HCC tissue up-regulated expression Our results showed that the expression level of SNHG3 was significantly upregulated in HCC tissues compared with paired noncancerous tissues from 51 HCC patients, increased SNHG3 expression is associated with malignant status and poor prognosis in HCC patients. 26373735 Lnc2Cancer
EL1230 SNHG4 myelodysplastic syndrome N/A N/A N/A mutation Association identified by GWAS. 19240791 LncRNADisease
EL1231 SNHG5 lymphoma N/A N/A N/A locus snhg5 is located at the breakpoint of chromosomal translocation t(3;6)(q27;q15) involved in human B-cell lymphoma. 10792466 LncRNADisease
EL1233 SNHG8 malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL1234 SNORA17B malignant pleural mesothelioma microarray, qPCR etc. MPM tissue, cell lines (H28, H226, H2052, H2452, MSTO etc.) up-regulated N/A AK130977 and AX746718 were both found to be down-regulated via both microarray and RT-qPCR (AK130977 Microarray (MA) = -5.207, RT-qPCR = -1.6; AX746718 MA = -3.37, RT-qPCR = -4.6), with AK130977 demonstrating fairly small changes using RT-qPCR. Similarly, BX648695, AK129685, EF177379, AK054908, AK130275, AF268386 and NR_003584 all demonstrated consistent up-regulation using both microarrays and RT-qPCR. 23976967 Lnc2Cancer
EL1236 SOX2-OT Alzheimer's disease N/A N/A N/A expression We selected three differential signature genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage (D14Ertd449, Tia1, Txnl4, 1810014B01Rik). 21961160 LncRNADisease
EL1236 SOX2-OT Neurodevelopmental syndromes associated with the SOX2 locus N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL1236 SOX2-OT esophageal squamous cell carcinoma N/A N/A N/A expression The results revealed a significant co-upregulation of SOX2OT along with SOX2 and OCT4 in tumor samples, compared to the non-tumor tissues obtained from the margin of same tumors. Therefore, the SOX2 gene might be a indicator for the early diagnosis of ESCC. 24817925 LncRNADisease
EL1236 SOX2-OT esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (NT2, U-87 MG etc.) up-regulated N/A Our data revealed a high level of SOX2OT expression in tumor samples of ESCC, compared to that of apparently normal marginal tissues obtained from the same patients (P<0.01). All together, our data provide a novel regulatory mechanism governing the key stem cell pluripotency genes, SOX2 and OCT4, mediated by the lncRNA SOX2OT. 24105929 Lnc2Cancer
EL1236 SOX2-OT hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (HepG2, SMMC-7721) up-regulated expression lncRNA Sox2ot expression level was significantly higher in HCC tissues compared with adjacent non-tumor tissues. High expression of lncRNA Sox2ot was associated with histological grade, TNM stage, and vein invasion. 26097588 Lnc2Cancer
EL1236 SOX2-OT breast cancer qPCR, Western blot etc. cell lines (MCF10A) up-regulated N/A The expression of SOX2 and SOX2OT is concordant in breast cancer, differentially expressed in estrogen receptor positive and negative breast cancer samples and that both are up-regulated in suspension culture conditions that favor growth of stem cell phenotypes. Importantly, ectopic expression of SOX2OT led to an almost 20-fold increase in SOX2 expression, together with a reduced proliferation and increased breast cancer cell anchorage-independent growth. 25006803 Lnc2Cancer
EL1236 SOX2-OT lung squamous cell carcinoma qPCR, Western blot, knockdown, RIP etc. cell lines (A549, HCC827, SK-MES-1, NCI-H1299 etc.) up-regulated N/A Sox2ot exprssion in lung cancer is significantly higher and promotes cancer cell proliferation. Sox2ot plays an important role in regulating lung cancer cell proliferation, and may represent a novel prognostic indicator for the disease. 24927902 Lnc2Cancer
EL1236 SOX2-OT non-small cell lung cancer real-time quantitative reverse transcription PCR (qRT-PCR) lung tumor tissues up-regulated N/A SOX2OT knockdown significantly reduced the colony formation ability of cancer cells 26846097
EL1237 SOX2OT-S1 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (NT2, U-87 MG etc.) up-regulated N/A The results of qPCR revealed that SOX2OT-S1 and SOX2OT-S2 were overexpressed in tumor samples of ESCC, compared to their marginal non-tumor tissue counterparts. Furthermore, overexpression of SOX2OT-S2 in tumor samples, similar to SOX2 and OCT4, was statistically significant (P<0.01). 24105929 Lnc2Cancer
EL1238 SOX2OT-S2 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (NT2, U-87 MG etc.) up-regulated N/A The results of qPCR revealed that SOX2OT-S1 and SOX2OT-S2 were overexpressed in tumor samples of ESCC, compared to their marginal non-tumor tissue counterparts. Furthermore, overexpression of SOX2OT-S2 in tumor samples, similar to SOX2 and OCT4, was statistically significant (P<0.01). 24105929 Lnc2Cancer
EL1239 Sox4 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL1240 SPRY4-IT1 melanoma knockdown, affinity purification, mass spectrometry melanoma cells up-regulated expression SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity. 25344859
EL1240 SPRY4-IT1 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL1240 SPRY4-IT1 breast cancer microarray, qPCR, Western blot, knockdown etc. breast cancer tissue, cell lines (MD-MB-231, MD-MB-435S, MCF-10A, MCF-7 etc.) up-regulated interaction SPRY4-IT1 expression was significantly upregulated in 48 breast cancer tumor tissues comparedwith normal tissues. Additionally, increased SPRY4-IT1 expression was found to be associated with a larger tumor size and an advanced pathological stage in breast cancer patients. SPRY4-IT1 is a novel prognostic biomarker and a potential therapeutic candidate for breast cancer. 25742952 Lnc2Cancer
EL1240 SPRY4-IT1 melanoma N/A N/A N/A expression The lncRNA, SPRY4-IT1, which is up-regulated in human melanomas compared to melanocytes and keratinocytes, affects cell dynamics, including increased rate of wound closure upon ectopic expression. 22492512 LncRNADisease
EL1240 SPRY4-IT1 melanoma N/A N/A N/A expression Another elegant study by Khaitan et al. utilized a non-coding RNA microarray approach to identify differentially regulated lncRNAs in melanoma cells and identified a 687 bp single exon lncRNA named SPRY4-IT1 which was highly up-regulated in melanoma patient samples and cell lines. 24115003 LncRNADisease
EL1240 SPRY4-IT1 esophageal squamous cell carcinoma qPCR etc. blood (plasma and serum) up-regulated expression Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. 25608466 Lnc2Cancer
EL1240 SPRY4-IT1 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (KYSE-450, KYSE-510, KYSE-150 etc.) up-regulated expression Long?noncoding?RNA?SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. 24810925 LncRNADisease Lnc2Cancer
EL1240 SPRY4-IT1 clear cell renal cell carcinoma qPCR, knockdown etc. ccRCC tissue, cell lines (786-O, ACHN, Caki-1, Caki-2) up-regulated expression The relative level of SPRY4-IT1 was significantly higher in ccRCC tissues compared to the adjacent normal renal tissues. And higher expression of SPRY4-IT1 was found in renal cancer cell lines compared with the normal human proximal tubule epithelial cell line HK-2. The ccRCC patients with higher SPRY4-IT1 expression had an advanced clinical stage and poorer prognosis than those with lower SPRY4-IT1 expression. 25337221 Lnc2Cancer
EL1240 SPRY4-IT1 bladder cancer qPCR, knockdown etc. bladder cancer tissue, cell lines (J82, T24, SW780, SV-40 etc.) up-regulated expression SPRY4-IT1 levels were highly positively correlated with histological grade, tumor stage, and lymph node metastasis and reduced overall survival. A multivariate analysis showed that SPRY4-IT1 expression is an independent prognostic factor of overall survival in patients with UCB. 25973088 Lnc2Cancer
EL1240 SPRY4-IT1 melanoma qPCR, knockdown, FISH etc. melanoma tissue up-regulated N/A The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. 21558391 LncRNADisease Lnc2Cancer
EL1240 SPRY4-IT1 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines AGS, BGC-823, HGC-27, SGC-7901, MGC80-3, MKN-45) up-regulated N/A SPRY4-IT1 expression was elevated in GC tissues and cell lines 25835973 LncRNADisease Lnc2Cancer
EL1240 SPRY4-IT1 gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, AGS, MKN45 etc.) down-regulated expression SPRY4-IT1 expression is decreased in gastric cancer tissues and associated with larger tumor size, advanced pathological stage, deeper depth of invasion and lymphatic metastasis. Patients with lower SPRY4-IT1 expression had a relatively poor prognosis. DNA methylation may be a key factor in controlling the SPRY4-IT1 expression. Furthermore, SPRY4-IT1 contributed to gastric cancer cells metastasis might partly via regulating epithelial-mesenchymal transition (EMT) process. 26238992 Lnc2Cancer
EL1240 SPRY4-IT1 glioma qPCR, Western blot, knockdown etc. glioma cell lines (U251, SF295) and the normal human astrocytes (NHA) up-regulated expression We examined for the first time the expression and role of SPRY4-IT1 in glioma cells. The results of our study showed that SPRY4-IT1 was up-regulated in human glioma tissues and cell lines. Knockdown of SPRY4-IT1 could inhibit glioma cell growth and migration. Moreover, knockdown of SPRY4-IT1 could inhibit epithelial-mesenchymal transition (EMT) phenotype in glioma cells. 26464658 Lnc2Cancer
EL1240 SPRY4-IT1 non-small-cell lung cancer qRT-PCR patients suffering from non-small-cell lung cancer (NSCLC) up-regulated expression N/A 26448925
EL1240 SPRY4-IT1 melanoma qRT-PCR, WB, knockdown severe preeclamptic placenta, trophoblast cells HTR-8/SVneo up-regulated expression SPRY4-IT1 knockdown enhanced the cell migration and proliferation, and reduced the response of cells to apoptosis. However, exogenous SPRY4-IT1 overexpression significantly decreased the cell migration and proliferation, while increased cell apoptosis. 24223182
EL1241 SRA1 breast cancer N/A N/A N/A expression Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines. 12565891 LncRNADisease
EL1241 SRA1 cardiomyopathy N/A N/A N/A N/A SRA1 results independently in a phenotype of myocardial contractile dysfunction. 19064678 LncRNADisease
EL1241 SRA1 dilated cardiomyopathy N/A N/A N/A expression RA also is present in a 600-kb linkage disequilibrium block associated with human dilated cardiomyopathy in 3 independent populations. 23104877 LncRNADisease
EL1241 SRA1 breast cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
EL1241 SRA1 ovarian cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
EL1241 SRA1 uterus cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
EL1241 SRA1 breast cancer qPCR etc. cell lines (BT-20, MDA-MB-469, MDA-MB-231 etc.) differential expression expression We recently reported a decreased estrogen receptor activity in breast cancer cells overexpressing SRAP, suggesting antagonist roles played by SRA1 RNA and SRAP. 16848684 LncRNADisease Lnc2Cancer
EL1241 SRA1 laryngeal squamous cell carcinoma qPCR etc. LSCC tissue down-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
EL1241 SRA1 breast cancer qPCR, Western blot etc. breast cancer tissue, cell line (T5) up-regulated locus We have previously found that both fully-spliced SRAP-coding and intron-1-containing non-coding SRA RNAs co-exist in breast cancer cell lines. 19483093 LncRNADisease Lnc2Cancer
EL1241 SRA1 breast cancer Western blot etc. cell line (HEK293T ) differential expression N/A Disturbance of the balance between SRAP1-coding and non-coding SRA1 RNAs in breast tumor tissues might be involved in breast tumorigenesis. 20079837 LncRNADisease Lnc2Cancer
EL1245 Srsf9 ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL1246 ST7-AS1 autism N/A N/A N/A locus The apparent noncoding genes at the ray1/st7 locus may be regulatory rnas. 12213198
EL1246 ST7-AS1 glioma qPCR etc. cell lines(U251, U87) up-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
EL1247 ST7-AS2 autism N/A N/A N/A locus The apparent noncoding genes at the ray1/st7 locus may be regulatory rnas. 12213198
EL1248 ST7-OT3 autism N/A N/A N/A locus The apparent noncoding genes at the ray1/st7 locus may be regulatory rnas. 12213198
EL1249 ST7-OT4 autism N/A N/A N/A locus The apparent noncoding genes at the ray1/st7 locus may be regulatory rnas. 12213198
EL1250 SUMO1P3 bladder cancer N/A bladder cancer tissues up-regulated expression Up-regulated SUMO1P3 expression was positively correlated with greater histological grade (P<0.05) and advanced TNM stage (P<0.05). cell proliferation / migration inhibition and apoptosis induction were also observed in SUMO1P3 siRNA-transfected bladder cancer cells. SUMO1P3 plays oncogenic roles in bladder cancer and can be used as a potential prognostic and therapeutic target. 26799188
EL1250 SUMO1P3 gastric cancer N/A N/A N/A expression Pseudogene-expressed lncRNAs are a major member of the lncRNA family. Recently, our group reported that small ubiquitin-like modifier (SUMO) 1 pseudogene 3, SUMO1P3, was markedly up-regulated in gastric cancer tissues compared with paired adjacent non-tumor tissues. 24833871 LncRNADisease
EL1250 SUMO1P3 gastric cancer qPCR etc. gastric cancer tissue up-regulated regulation Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association. 23996296 LncRNADisease Lnc2Cancer
EL1263 TARID cancer N/A N/A N/A N/A Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. 25087872 LncRNADisease
EL1266 TC0100223 epithelial ovarian cancer microarray, qPCR etc. epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) down-regulated expression Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. 24481591 LncRNADisease Lnc2Cancer
EL1267 TC0101441 epithelial ovarian cancer microarray, qPCR etc. epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) up-regulated expression Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. 24481591 LncRNADisease Lnc2Cancer
EL1267 TC0101441 epithelial ovarian cancer microarray, qPCR, Western blot, knockdown etc. epithelial ovarian cancer tissue, cell lines (SKOV3, A2780, PEO1 etc.) up-regulated N/A The results showed that ERa-positive tissues had higher expression of TC0101441 and lower expression TC0101686. Low-expression of TC0101686 was significantly related to ERa-positive EOC tissues with advanced FIGO stage ( P< 0.05), while high-expression of TC0101441 was closely correlated with advanced FIGO stage, high histological grade and lymph node metastasis (P<0.01). 24380700 Lnc2Cancer
EL1268 TC0101686 epithelial ovarian cancer microarray, qPCR etc. epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) down-regulated expression Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade. 24481591 LncRNADisease Lnc2Cancer
EL1268 TC0101686 epithelial ovarian cancer microarray, qPCR, Western blot, knockdown etc. epithelial ovarian cancer tissue, cell lines (SKOV3, A2780, PEO1 etc.) down-regulated N/A The results showed that ERa-positive tissues had higher expression of TC0101441 and lower expression TC0101686. Low-expression of TC0101686 was significantly related to ERa-positive EOC tissues with advanced FIGO stage ( P< 0.05), while high-expression of TC0101441 was closely correlated with advanced FIGO stage, high histological grade and lymph node metastasis (P<0.01). 24380700 Lnc2Cancer
EL1269 TC1500845 ovarian cancer microarray, qPCR etc. epithelial ovarian cancer tissue, cell lines (SKOV3 etc.) up-regulated N/A The results revealed that the expression levels of TC0100223 and TC0101686 were significantly downregulated by E2, whereas TC1500845 and TC0101441 were significantly upregulated by E2 in SKOV3 cells, consistent with the microarray results. 24481591 LncRNADisease Lnc2Cancer
EL1270 TCF7 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue down-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL1271 TCL6 acute T-lymphocytic leukemia qPCR etc. cell lines (COS7 ) up-regulated N/A T-cell leukemia/lymphoma 6 10851082 LncRNADisease Lnc2Cancer
EL1273 TCONS_00000966 Sclerotinia stem rot caused by Sclerotinia sclerotiorum qRT-PCR responsive to S. sclerotiorum infection in B. napus at two time points after infection (24 hpi and 48 hpi) N/A expression TCONS_00000966, having 90% overlap with a plant defensin gene, showed significant induction at both infection stages, suggesting its involvement in the transcriptional regulation of defense responsive genes under S. sclerotiorum infection. 27388760
EL1281 TCONS_00014512 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1282 AC069120.3 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1283 TCONS_00018278 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated N/A To validate the microarray analysis results, five lncRNAs were randomly selected from the differential lncRNAs and their expressions were analyzed using qPCR in 29 pairs of HCC and matched NT tissues. Our data indicated that the expressions of TCONS_00018278, AK093543, D16366 and ENST00000501583 were significantly downregulated in HCC, whereas the expression of NR_002819 showed no significant difference. 24876753 Lnc2Cancer
EL1288 TCONS_00024647 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1289 TCONS_00026506 colorectal cancer microarray, qPCR etc. cell line (HCT116) up-regulated expression To validate the microarray results, we randomly selected 6 differentially expressed lncRNAs (TCONS_00026506, ENST00000468960, NR_038990, ENST00000575202, ENST00000539009 and ENST00000544591) between CRR-HCT116 and parental HCT116 cells to confirm their expression levels by qPCR. Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. 25921151 Lnc2Cancer
EL1309 TCONS_00090092_MEG3 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1310 TCONS_l2_00000179 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1311 TCONS_l2_00003938 triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
EL1312 TCONS_l2_00004424 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1313 TCONS_l2_00006843 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1314 TCONS_l2_00010365 papillary thyroid carcinoma microarray, qPCR etc. papillary thyroid carcinoma tissue up-regulated expression We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. 26003293 Lnc2Cancer
EL1315 TCONS_l2_00014091 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1316 TCONS_l2_00018070 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1317 TCONS_l2_00018071 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1318 TCONS_l2_00020565 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1319 TCONS_l2_00021262 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue up-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1320 TCONS_l2_00030560 hepatoblastoma microarray, qPCR etc. hepatoblastoma tissue down-regulated N/A The results showed that expression of TCONS_00090092-MEG3, TCONS_l2_00000179, TCONS_l2_00014091, TCONS_l2_00004424, TCONS_l2_00021262, TCONS_00014978 and ESM1 were over-regulated, and TCONS_l2_00018070, TCONS_l2_00018071, TCONS_l2_00006843, TCONS_l2_00030560, TCONS_l2_00020565, TCONS_00024647, and TCONS_00014512 were downregulated in all four hepatoblastoma tissue samples relative to the paired distant noncancerous tissues (P<0.05). 24465615 Lnc2Cancer
EL1321 TDRG1 testicular cancer N/A N/A N/A expression The significantly reduced expression of the TDRG1 in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene. 21243750 LncRNADisease
EL1321 TDRG1 aplastic anemia Reverse transcription‑quantitative polymerase chain, small interfering RNA patients exhibiting AA up-regulated interaction The decreased proliferation capability of BMSCs that were treated with Ad‑FGF1 and TDRG1‑small interfering RNA validated the vital effect of TDRG1 on the FGF1 regulatory process of BMSC differentiation. 26460236
EL1325 TERC dyskeratosis congenita N/A N/A N/A mutation Mutations that alter the equilibrium between different conformational states of TERCs result in disease states such as dyskeratosis congenita, presumably through disruptions of the RNA scaffold structure into which are plugged modular binding sites for telomeric regulatory proteins. 14630939 LncRNADisease
EL1325 TERC prostate cancer N/A N/A N/A expression TERC is expressed in all human tissues regardless of telomerase activity, whereas TERT is highly expressed in >90% of tumor cells 24146262 LncRNADisease
EL1328 THRIL Kawasaki disease N/A N/A N/A expression Finally, THRIL expression was correlated with the severity of symptoms in patients with Kawasaki disease, an acute inflammatory disease of childhood. 24371310 LncRNADisease
EL1329 TI09485 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) down-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1330 TI10124 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) up-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1331 TI13831 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) up-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1332 TI18318 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) up-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1333 TI21327 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) down-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1334 TI22687 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) down-regulated N/A LncRNA expression was then analyzed in CC cells and normal, primary cervical epithelial cells in the same manner. The levels of TI17313, TI13831, TI10124, and TI18318 were increased in 3 cancer cell lines (HeLa, SiHa, and CaSki) when compared with normal, primary cervical epithelial cells. Expression of the 5 other lncRNAs was below the level of detection in cultured cells. 25007342 Lnc2Cancer
EL1336 TINCR skin desease Genome-scale RNA interactome analysis, high-throughput screen N/A N/A N/A controls human epidermal differentiation by a post-transcriptional mechanism 23201690
EL1336 TINCR colorectal cancer N/A CRC tissues and metastatic CRC cell lines up-regulated N/A TINCR was reversely correlated with CRC progression 27009809
EL1336 TINCR squamous cell carcinoma N/A N/A N/A expression Interestingly, the lncRNA TINCR, which is highly induced during keratinocyte differentiation, is repressed in squamous cell carcinoma specimens compared to normal adjacent epidermis. 24115003 LncRNADisease
EL1336 TINCR gastric cancer RNA-seq, qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (MGC803, BGC823, MKN45, SGC7901 etc.) up-regulated N/A TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression. TINCR overexpression is induced by nuclear transcription factor SP1. TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. 25728677 LncRNADisease Lnc2Cancer
EL1341 Tmcc3 diabetic nephropathy Western blotting, and quantitative RT-PCR mouse mesangial cells down-regulated interaction downregulated ENSMUST00000147869 associated with Cyp4a12a 27083175
EL1342 TMEM179 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1343 TMEM72 clear cell renal cell carcinoma microarray, qPCR etc. renal clear cell carcinoma tissue down-regulated N/A ENST00000456816, X91348, BC029135, NR_024418 were evaluated by qPCR in sixty-three pairs of RCCC and NT samples. The results demonstrated that ENST00000456816, X91348 were up-regulated and BC029135, NR_024418 were down-regulated in RCCC samples compared with NT samples (p<0.001 for each lncRNAs). 22879955 Lnc2Cancer
EL1346 TMPOP2 cervical cancer microarray, qPCR, Western blot, knockdown, RIP etc. cervical cancer tissue, cell lines (HeLa, SiHa, CaSki) up-regulated N/A lncRNA-EBIC was upregulated in cervical cancer. lncRNA-EBIC was an oncogenic lncRNA, which could promote tumor cell invasion in CC by binding to EZH2 and inhibiting E-cadherin expression. 25007342 Lnc2Cancer
EL1347 TNXA bladder cancer microarray, qPCR, knockdown etc. bladder cancer tissue down-regulated N/A Four lncRNAs were selected for further confirmation of microarray results using qPCR. These lncRNAs were among the most downregulated or upregulated lncRNAs. Data analysis showed that KRT19P3 was upregulated and TNXA, CTA-134P22.2 and CTC-276P9.1 were downregulated in bladder cancer samples compared with matched normal tissues.these deregulated lncRNAs play a key or partial role in the development and/or progression of bladder cancer. 24944692 Lnc2Cancer
EL1349 TP53COR1 colorectal cancer limiting dilution and serial tumor formation assay colorectal cancer stem cells N/A interaction Large intergenic non-coding RNA p21 (lincRNA-p21) is a potent suppressor of stem-like traits of CSCs purified from both primary colorectal cancer (CRC) tissues and cell lines. Ad-lnc-p21-MRE significantly suppressed the self-renewal potential and tumorigenicity of CSCs in nude mice. 26497997
EL1349 TP53COR1 lung cancer N/A N/A N/A expression lincRNAp21 is required for the global repression of genes that interfere with p53 function regulating cellular apoptosis. lincRNAp21 can mediate gene repression by physically interacting with the protein hnRNP-K, allowing its localization to promoters of genes to be repressed in a p53-dependent manner, and its overexpression in a lung cancer cell line sensitizes the cells to DNA 22535282 LncRNADisease
EL1349 TP53COR1 atherosclerosis N/A N/A N/A N/A The expression of lincRNA-p21 was dramatically downregulated in atherosclerotic plaques of ApoE(-/-) mice, an animal model for atherosclerosis. LincRNA-p21 represses cell proliferation and induces apoptosis in vascular smooth muscle cells and mouse mononuclear macrophage cells in vitro 25156994 LncRNADisease
EL1349 TP53COR1 lung cancer qPCR etc. cell lines (wt MEFs, NIH/3T3 MEFs etc.) down-regulated expression Gas5 has also been linked with breast cancer because Gas5 transcript levels are significantly reduced compared to unaffected normal breast epithelia. 20673990 LncRNADisease Lnc2Cancer
EL1349 TP53COR1 cervical cancer qPCR etc. cell line (CaSki) up-regulated N/A Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. The decline in the expression of HOTAIR and MALAT1 was clearly evident in BLM-treated HeLa and MCF cells. For lincRNA-p21, ncRNA-CCND1, and MEG3, a similar up-regulation pattern was obvious in both cell lines where the increase was generally more pronounced in BLM-treated cells. 22487937 LncRNADisease Lnc2Cancer
EL1349 TP53COR1 chronic lymphocytic leukemia qPCR etc. blood (plasma) down-regulated expression HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. 24583225 LncRNADisease Lnc2Cancer
EL1349 TP53COR1 prostate cancer qPCR etc. prostate cancer tissue up-regulated expression The lincRNA-p21 levels were significantly higher in PCa than in BPH. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa. 25999983 Lnc2Cancer
EL1349 TP53COR1 B cell lymphoma qPCR, Western blot etc. B cell lymphoma tissue, DLBCL cell lines (SU-DHL-2, OCI-LY-3, OCILY-10, SU-DHL-4, OCI-LY-7) down-regulated interaction We found that lincRNA-p21 levels were markedly decreased in DLBCL tissues compared with normal. Its expression level was significantly correlated with Ann Arbor stages, B symptoms, performance status, IPI score and serum LDH. Moreover, patients with high levels of LincRNA-p21 expression had a favorable overall survival and progression-free survival. Furthermore, ectopic expression of lincRNA-p21 inhibited cell proliferation, arrested cycle progression and modulated cyclin D1, CDK4 and p21 expression in DLBCL cell lines. These results demonstrated lincRNA-p21 can be identified as a potential novel prognostic biomarker for prognosis in DLBCL and regulate cell proliferation and cycle in vitro 26475621 Lnc2Cancer
EL1349 TP53COR1 colorectal cancer qPCR, Western blot, knockdown etc. CRC tissue, cell lines (SW1116, SW620, LS 174T, HT29, LOVO etc.) down-regulated regulation LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. 24573322 LncRNADisease Lnc2Cancer
EL1349 TP53COR1 Burkitt's lymphoma qPCR, Western blot, knockdown etc. blood up-regulated expression We analyzed its expression in CLL and lymphoma in the context of DNA damage. 24 hours after IR, lincRNA-p21 expression was strongly induced in a p53-dependent manner in a very large set of CLL patients (n = 73).lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. 25971364 Lnc2Cancer
EL1349 TP53COR1 chronic lymphocytic leukemia qPCR, Western blot, knockdown etc. blood up-regulated expression We analyzed its expression in CLL and lymphoma in the context of DNA damage. 24 hours after IR, lincRNA-p21 expression was strongly induced in a p53-dependent manner in a very large set of CLL patients (n = 73).lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. 25971364 Lnc2Cancer
EL1349 TP53COR1 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. hepatocellular cancer tissue down-regulated expression We demonstrated that lincRNA-p21 acted as a tumor suppressive lncRNA in human hepatocellular carcinoma. We firstly found the downregulation of lincRNA-p21 level in human hepatocellular carcinoma tissues, and showed that low expression of lincRNA-p21 was associated with high disease stage and predicted poor survival.We showed that lincRNA-p21 knockdown promoted proliferation and colony formation of HepG2, Huh7 and Bel-7042 cells in vitro, while lincRNA-p21 overexpression obtained oppose results.We demonstrated that ER stress accounted for lincRNA-p21 effects on apoptosis, proliferation and in vivo growth of hepatocellular carcinoma. 26305675 Lnc2Cancer
EL1350 TP53TG1 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) down-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL1350 TP53TG1 ataxia telangiectasia N/A human T lymphocytes from patient with ataxia telangiectasia (AT) up-regulated expression TP53TG1 demonstrated a weak up-regulation, reaching a maximum of 1.5-fold at 24 h after radiation exposure 25738893
EL1351 TP73-AS1 multiple myeloma methylation-specific PCR etc. cell lines (KMS-12-PE, LP-1, NCI-H929, OPM-2, OCI-MY5) differential expression expression Herein, by methylation-specific PCR, the putative KIAA0495 promoter was found unmethylated in all healthy controls (N = 14) but methylated in 50 % of myeloma cell lines (N = 10). KIAA0495 methylation was shown inversely correlated with KIAA0495 expression. However, KIAA0495 methylation was detected in none of both primary myeloma samples at diagnosis (N = 61) and at relapse/progression (N = 16). Collectively, despite frequently methylated in cell lines, KIAA0495 methylation appeared unimportant in the pathogenesis or progression of myeloma. 26410378 Lnc2Cancer
EL1351 TP73-AS1 esophageal squamous cell carcinoma microarray, knockdown esophageal squamous cell carcinoma, mouse xenografts up-regulated interaction In mouse xenografts, tumor size was reduced in lncRNA TP73-ASI siRNA-transfected tumors, suggesting that downregulation of lncRNA TP73-AS1 attenuated EC proliferation in vitro and in vivo. lncRNA TP73-AS1 knockdown enhanced the chemosensitivity of esophageal cancer cells to 5-FU and cisplatin. 26799587
EL1351 TP73-AS1 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression Furthermore, the levels of LINC00261 and TP73-AS1 were significantly differently expressed in subgroups of NSCLC samples (P = 0.004 and P = 0.03, respetcively). These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
EL1355 TRAF3IP2-AS1 cocaine abuse lncRNA microarray, qRT-PCR, in situ hybridization histochemistry postmortem human midbrain tissues from chronic cocaine abusers up-regulated expression The abundances of these transcripts were significantly correlated (left) suggesting that TRAF3IP2-AS1 may regulate TRAF3IP2 (tumor necrosis factor receptor-associated factor 3-interacting protein 2) gene expression, perhaps through local chromatin changes at this locus (right). 26222413
EL1355 TRAF3IP2-AS1 schizophrenia N/A N/A N/A N/A Association 10903453 LncRNADisease
EL1363 TRERNA1 hepatocellular carcinoma N/A hepatoma cells N/A expression miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. 26608035
EL1364 TRIM52-AS1 renal cell carcinoma reverse transcription‑quantitative polymerase chain reaction analysis RCC cells up-regulated N/A TRIM52‑AS1 functions as a tumor suppressor in RCC 26934858
EL1365 Trp53cor1 carcinogen furan microarray analysis, quantitative RT-PCR livers of female B6C3F1 mice exposed to the carcinogen furan at 0.0, 1.0, and 2.0mg/kg (noncarcinogenic doses) and at 4.0 and 8.0mg/kg (carcinogenic doses) for 3 weeks up-regulated expression LincRNA-p21 is an antisense transcript that is 15kb downstream from Cdkn1a locus and appears to be cotranscribed with the protein coding gene Cdkn1a at 8.0mg/kg furan. 23853263
EL1365 Trp53cor1 tumor N/A N/A N/A regulation Global gene repression in the p53 transcriptional response by binding hnRNP-K, inducing cellular apoptosis. 22996375 LncRNADisease
EL1365 Trp53cor1 cancer N/A N/A N/A expression lincRNA-p21 (named for its vicinity to the CDKN1A/p21 locus) is upregulated by p53 upon DNA damage and implicated in downstream repressive effects of the p53 pathway, particularly on genes regulating apoptosis, possibly by directing the recruitment of hnRNP-K to its genomic targets. 23463798 LncRNADisease
EL1365 Trp53cor1 tumor N/A N/A N/A regulation Thus, similar to its activator p53, lincRNA-p21 may play an important role in tumour suppression by operating as a transcriptional repressor. 23660942 LncRNADisease
EL1365 Trp53cor1 tumor N/A N/A N/A regulation Global gene regulation p53 repression via hnRNP-K; inducing cellular apoptosis 24499465 LncRNADisease
EL1365 Trp53cor1 tumor N/A N/A N/A regulation ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators. 24667321 LncRNADisease
EL1365 Trp53cor1 cancer N/A N/A N/A regulation They identified lincRNA-p21 as a direct p53 target. Furthermore, they found that lincRNA-p21 is critical in regulating many of the genes that are repressed in response to p53 activity and they found that lincRNA-p21 associates with hnRNP-K. The lincRNA-p21/hnRNP-K interaction was found to be necessary for hnRNP-K genomic localization at sites of gene repression. 24829860 LncRNADisease
EL1365 Trp53cor1 colorectal cancer qPCR etc. CRC tissue, cell lines (HCT-116 (p53t/t), HCT-116(p53-/-) etc.) down-regulated expression One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts. 24012455 LncRNADisease Lnc2Cancer
EL1366 TRPM2-AS prostate cancer microarray, qPCR etc. cell line (PC3) differential expression expression This essential role, coupled to the TRPM2-AS low-expression levels in healthy tissues, makes this ncRNA a suitable therapeutic target for further clinical studies. To get insights into the survival mechanism controlled by this molecule, we ablated its expression in prostate cancer cells and performed a genome-wide analysis of the transcripts differentially regulated in dying cells. 26484139 Lnc2Cancer
EL1366 TRPM2-AS prostate cancer microarray, qPCR, knockdown etc. prostate cancer tissue, cell lines (PNT1A, PC3 etc.) up-regulated N/A TRPM2-AS is overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature were found to be linked to poor clinical outcome, with the related gene signature working also independently of the patient's Gleason score. Mechanistically, TRPM2-AS knockdown led to PCa cell apoptosis, with a transcriptional profile that indicated an unbearable increase in cellular stress in the dying cells, which was coupled to cell cycle arrest, an increase in intracellular hydrogen peroxide and activation of the sense TRPM2 gene. 24931166 Lnc2Cancer
EL1367 Trpm3 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 25 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL1368 TSIX systemic sclerosis real-time PCR and in situ hybridization, immunoblotting dermal fibroblasts, serum up-regulated interaction TSIX siRNA reduced the mRNA expression of type I collagen in normal and SSc dermal fibroblasts, but not the levels of major disease-related cytokines. In addition, TSIX siRNA significantly reduced type I collagen mRNA stability, but not protein half-lives. TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA. 26566700
EL1370 TSNAX-DISC1 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated expression The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1371 TSPAN8 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1396 TUBA4B non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression RP11-385J1.2 and TUBA4B were the most markedly changed of these candidate lncRNAs from 90 NSCLC and normal lung tissue samples. As shown in Fig. 4, RP11-385J1.2 expression in NSCLC was significantly higher than in the adjacent tissues, while TUBA4B expression in NSCLC was significantly lower than in the adjacent tissues. 25394782 Lnc2Cancer
EL1397 TUC339 hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (Hep3B, HepG2, PLC/PRF/5 etc.) up-regulated N/A The most highly significantly expressed ucRNA in HCC cell-derived extracellular vesicles was cloned and identified as a 1,198-bp ucRNA, termed TUC339. TUC339 was functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduced HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, intercellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread. 24167654 Lnc2Cancer
EL1398 T-UCRs neuroblastoma N/A N/A N/A regulation It is now becoming increasingly evident that N-myc also regulates the expression of long noncoding RNAs such as T-UCRs and ncRAN. 22936790 LncRNADisease
EL1399 TUG1 prostate cancer integrating analysis of sequence features and gene expression profiles prostate cancer up-regulated N/A sub-cellular localization-dependent function 26975529
EL1399 TUG1 gastric cancer knockdown of TUG1 repressed GC proliferation non-small cell lung cancer up-regulated N/A TUG1 was associated with PRC2 26913601
EL1399 TUG1 Huntington's disease N/A N/A N/A expression TUG1 is upregulated in Huntington's disease brains, which is from the reanalysis of the Affymetrix U133A and B microarray data on normal and HD brains in this review. 22202438 LncRNADisease
EL1399 TUG1 Huntington's disease N/A N/A N/A expression LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD. 23346095 LncRNADisease
EL1399 TUG1 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL1399 TUG1 bladder cancer N/A N/A N/A regulation Putative diagnostic and prognostic marker; oncogene 24373479 LncRNADisease
EL1399 TUG1 osteosarcoma qPCR etc. osteosarcoma tissue, cell lines (U2OS etc.) up-regulated N/A We found significantly higher TUG1 and n377360 expression levels in osteosarcoma tissues compared with matched non-tumorous tissues. Suppression of TUG1 and n377360 expression by siRNA significantly impaired the cell proliferation potential of osteosarcoma cells. Furthermore, inhibition of TUG1 expression significantly promoted osteosarcoma cell apoptosis. The overexpression of TUG1 and n377360 in osteosarcoma specimens and the functional role of TUG1 and n377360 regarding cell proliferation and apoptosis in an osteosarcoma cell line provided evidence that the use of TUG1 or n377360 may be a viable but an as yet unexplored therapeutic strategy in tumors that over express these factors. 23725133 Lnc2Cancer
EL1399 TUG1 multiple myeloma qPCR etc. blood (plasma) up-regulated N/A In our study, TUG1 levels were investigated in cell free plasma samples and higher expression was only observed in the MM group although correlation with disease state was observed both in the CLL and MM groups. 24583225 LncRNADisease Lnc2Cancer
EL1399 TUG1 glioma qPCR etc. cell lines(U251, U87) down-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
EL1399 TUG1 urothelial carcinoma of the bladder qPCR, knockdown etc. cell lines (T24, 5637 etc. up-regulated expression Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder. 22961206 LncRNADisease Lnc2Cancer
EL1399 TUG1 esophageal squamous cell carcinoma qPCR, knockdown, FCA etc. ESCC tissue up-regulated interaction TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer. Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. 25366138 Lnc2Cancer
EL1399 TUG1 non-small cell lung cancer qPCR, Western blot, Luciferase reporter assay, knockdown etc. cell lines (A549, SK-MES-1, NCI-H1299 etc.) down-regulated regulation P53-regulated?long?non-coding?RNA?TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. 24853421 LncRNADisease Lnc2Cancer
EL1399 TUG1 bladder cancer qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. bladder cancer tissue, up-regulated interaction We confirmed that TUG1 was overexpressed in bladder cancer tissues and established cell lines. Knockdown of TUG1 inhibited bladder cancer cell metastasis both in vitro and in vivo. Furthermore, we found that TUG1 promoted cancer cell invasion and radioresistance through inducing epithelial-to-mesenchymal transition (EMT). Interestingly, TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner. ZEB2 was identified as a down-stream target of miR-145 and TUG1 exerted its function through the miR-145/ZEB2 axis. 26318860 Lnc2Cancer
EL1399 TUG1 hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay, knockdown, RIP etc. HCC tissue, cell lines (HepG2, MHCC-97H, Hep3B) up-regulated interaction TUG1 expression was up-regulated in HCC tissues and the higher expression of TUG1 was significantly correlated with tumor size and Barcelona Clinic Liver Cancer (BCLC) stage. Moreover, silencing of TUG1 expression inhibited HCC cell proliferation, colony formation, tumorigenicity and induced apoptosis in HCC cell lines. We also found that TUG1 overexpression was induced by nuclear transcription factor SP1 and TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. 26336870 Lnc2Cancer
EL1399 TUG1 colorectal cancer quantitative real-time PCR cultured representative CRC cell lines and 120 CRC patients up-regulated N/A increased their colony formation, migration, and invasion in vitro 26856330
EL1399 TUG1 glioma quantitative RT-PCR, Annexin V/PI staining and cell counting kit-8 assays glioma tissues down-regulated interaction The dysregulation of taurine upregulated gene 1 affected the apoptosis and cell proliferation of glioma cells. Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma. 26748401
EL1401 TUNAR breast cancer qPCR, Western blot, Luciferase reporter assays, RNA Pull-Down Assay, RPI etc. breast cancer tissues and adjacent nontumor tissues, cell lines (MCF7, T47D, BT474, and MDA-MB-468) up-regulated interaction We found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples. Linc00617 promoted motility and invasion of breast cancer cells and induced epithelial-mesenchymal-transition (EMT), which was accompanied by generation of stem cell properties. Moreover, knockdown of linc00617 repressed lung metastasis in vivo. We demonstrated that linc00617 upregulated the expression of stemness factor Sox2 in breast cancer cells, which was shown to promote the oncogenic activity of breast cancer cells by stimulating epithelial-to-mesenchymal transition and enhancing the tumor-initiating capacity 26207516 Lnc2Cancer
EL1402 TUSC7 osteosarcoma Cell counting kit 8 (CCK-8) assay, western blot osteosarcoma tissues down-regulated interaction Cell counting kit 8 (CCK-8) assay revealed that after silence of TUSC7, cell proliferation ability increased and the colony formation ability also increased. After silence of TUSC7, the proapoptotic Bcl2 expression was downregulated. Compared with negative control group, silence of TUSC7 significantly promoted tumor growth in vivo. Thus, we demonstrated that TUSC7 could be a potential tumor suppressor in osteosarcoma. 26781978
EL1402 TUSC7 osteosarcoma deletion analysis, reciprocal repression, quantitative PCR arrays and in situ hybridization of tissue microarrays N/A down-regulated N/A a tumor suppressor unit in osteosarcoma and to suppress tumor cell growth. ,loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo..loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. 23558749
EL1402 TUSC7 colon cancer deletion analysis, reciprocal repression, quantitative PCR arrays and in situ hybridization of tissue microarrays N/A down-regulated N/A a tumor suppressor unit in osteosarcoma and to suppress tumor cell growth. ,loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo..loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. 23558749
EL1402 TUSC7 osteosarcoma microarray, qPCR, FISH etc. osteosarcoma tissue, cell lines (U2OS, SAOS-2, HOS etc.) down-regulated mutation These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. 20048075 LncRNADisease Lnc2Cancer
EL1402 TUSC7 gastric cancer microarray, qPCR, knockdown etc. gastric cancer tissue down-regulated N/A The results indicated that TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients.The results indicated that TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. 25765901 LncRNADisease Lnc2Cancer
EL1402 TUSC7 hepatocelluar carcinoma N/A hepatocellular carcinoma down-regulated N/A inhibited cell metastasis, invasion, and epithelial-to-mesenchymal 27002617
EL1402 TUSC7 colorectal cancer qPCR etc. CRC tissue, cell lines (CaCO-2, HCT8, LoVo, CCC-HIE-2 etc.) down-regulated N/A The relative expression levels of LOC285194 was significantly lower in tumor tissues (p<0.001) and colorectal cancer cell lines compared with adjacent normal tissues and normal intestinal mucous cell line. In addition, low expression of LOC285194 was correlated with larger tumor size, higher tumor stage (p=0.034), and more distant metastasis (p=0.046). Our data indicate that LOC285194 might be a novel prognostic indicator in colorectal cancer and may be a potential target for diagnosis and gene therapy. 23680400 Lnc2Cancer
EL1402 TUSC7 esophageal squamous cell carcinoma qPCR, knockdown etc ESCC tissue, cell lines (KYSE30, KYSE 70, KYSE 150, KYSE510, Eca109) down-regulated N/A LOC285194 expression was significantly down-regulated in ESCC tumor tissues when compared with the adjacent normal tissues. Low expression of LOC285194 was associated with larger tumor size, advanced TNM stage, more lymph node metastases and distant metastases. 25169763 LncRNADisease Lnc2Cancer
EL1403 TUSC8 cervical cancer qPCR, Western blot, knockdown etc. cervical cancer tissue, cell lines (HeLa, SiHa, HCC94) down-regulated expression Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. 24667250 LncRNADisease Lnc2Cancer
EL1404 U1 spliceosomal lncRNA Parkinson's disease N/A N/A N/A expression These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing sequence complementarity to numerous microRNAs. 24651478 LncRNADisease
EL1405 Ube3a-ATS Angelman syndrome N/A N/A N/A N/A ASO treatment achieved specific reduction of Ube3a-ATS and sustained unsilencing of paternal Ube3a in neurons in vitro and in vivo. Partial restoration of UBE3A protein in an Angelman syndrome mouse model ameliorated some cognitive deficits associated with the disease. 25470045 LncRNADisease
EL1406 uc.115- heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 10 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL1407 uc.173 lead-induced nerve injury overexpress, quantitative real-time PCR a lead-induced nerve injury mouse model, N2a mouse nerve cell line down-regulated interaction Uc.173 had an inhibitory effect on lead-induced apoptosis of N2a. 26683706
EL1408 uc.184+ heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 19 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL1409 uc.283-plus glioma microarray, qPCR etc. glioma tissue up-regulated expression Among the normal tissues, the uc.283 lncRNA was highly specific for pluripotent stem cells. Intriguingly, the uc.283-plus lncRNA was highly expressed in some solid cancers, particularly in one of the most untreatable types, glioma.uc.283-plus lncRNA might have a role in pluripotency of stem cells and in the biology of glioma. 25352916 Lnc2Cancer
EL1410 uc.341 gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue up-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL1411 uc.388 colorectal cancer qPCR etc. CRC tissue down-regulated N/A Expression levels of uc.73 (p = 0.0139) and uc.388 (p = 0.0325) were significantly decreased in CRC tissue, and uc.73 indicated a positive correlation with overall survival. The lower expression of uc.388 was associated with the distal location of CRC (p = 0.0183). Our preliminary results suggest that uc.73 and uc.388 could be potential diagnostic and prognostic biomarkers in CRC patients. 22328099 Lnc2Cancer
EL1412 uc.73 colorectal cancer qPCR etc. CRC tissue down-regulated N/A Expression levels of uc.73 (p = 0.0139) and uc.388 (p = 0.0325) were significantly decreased in CRC tissue, and uc.73 indicated a positive correlation with overall survival. The lower expression of uc.388 was associated with the distal location of CRC (p = 0.0183). Our preliminary results suggest that uc.73 and uc.388 could be potential diagnostic and prognostic biomarkers in CRC patients. 22328099 Lnc2Cancer
EL1413 uc001aka.2 renal cell carcinoma microarray, qPCR etc. RCC tissue down-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1414 uc001gch.1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1415 uc001gzl.3 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1416 uc001lsz gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (GES-1, AGS, MGC-803, SGC-7901) down-regulated N/A The most down-regulated lncRNAs in gastric cancer tissues were FER1L4, uc001lsz, BG491697, AF131784, uc009ycs, BG981369, AF147447, HMlincRNA1600, and AK054588; while the most up-regulated ones were H19, HMlincRNA717, BM709340, BQ213083, AK054978, and DB077273. 24063685 Lnc2Cancer
EL1416 uc001lsz prostate cancer qPCR etc. cell lines ((Du-145, PC-3) up-regulated N/A We found that comparing with respective normal cell line, uc001lsz was lowly expressed in gastric cancer (AGS, MGC-803 and SGC-7901), lung cancer (A549) and liver cancer (SMMC-7721 and HepG2) cell lines, while only highly expressed in prostate cancer (Du-145 and PC-3) cell lines. 24063685 Lnc2Cancer
EL1416 uc001lsz liver cancer qPCR etc. cell lines (SMMC-7721, HepG2) down-regulated N/A We found that comparing with respective normal cell line, uc001lsz was lowly expressed in gastric cancer (AGS, MGC-803 and SGC-7901), lung cancer (A549) and liver cancer (SMMC-7721 and HepG2) cell lines, while only highly expressed in prostate cancer (Du-145 and PC-3) cell lines (Figure 3C). 24063685 Lnc2Cancer
EL1416 uc001lsz lung cancer qPCR etc. cell lines (A549) down-regulated N/A We found that comparing with respective normal cell line, uc001lsz was lowly expressed in gastric cancer (AGS, MGC-803 and SGC-7901), lung cancer (A549) and liver cancer (SMMC-7721 and HepG2) cell lines, while only highly expressed in prostate cancer (Du-145 and PC-3) cell lines. 24063685 Lnc2Cancer
EL1417 uc001ncr hepatocelluar carcinoma microarray, qPCR etc. HCC tissue down-regulated expression We determined that a panel based on the expression of uc001ncr and AX800134 accurately diagnosed HBV-positive HCC (AUC values of 0.9494 and 0.9491 for the training and validation cohorts, respectively). The diagnostic performance of the panel remained high in patients with AFP>=400 ng/ml (AUC values of 0.9371 and 0.9527 for the training and validation cohorts, respectively). The panel also diagnosed early HCC (AUC values of 0.9450 and 0.9564 for the training and validation cohorts, respectively) 26674525 Lnc2Cancer
EL1418 LOC100288208 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1419 uc002nbr.3 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue down-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL1420 LINC01589 non-small cell lung cancer microarray, qPCR, Western bolt, knockdown etc. cell lines (A549, CDDP etc.) up-regulated N/A For lncRNA, the results showed that AK123263, CES1P1-001, RP3-508I15.14, AK126698, TP53TG1, and AC090952.4.1 decreased, whereas uc003bgl.1 and NCRNA00210 increased in A549/CDDP (all P <0.05). Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs. Among these, AK126698 appears to confer cisplatin resistance by targeting the Wnt pathway. 23741487 Lnc2Cancer
EL1421 uc003erl.1 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1422 uc003iqu gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue up-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL1423 uc003jfz.2 gastric cardia adenocarcinoma microarray, qPCR etc. gastric cancer tissue up-regulated N/A We found that ASHG19A3A029791, ASHG19A3A034382, ASHG19A3A028003, ASHG19A3A013479, ASHG19A3A022744, ASHG19A3A025864, ASHG19A3A043106 and ASHG19A3A03455, were up-regulated, and ASHG19A3A007791, ASHG19A3A050006, ASHG19A3A051125, ASHG19A3A011053 were down-regulated in the GCa samples compared with normal samples. Thus, the results from the qPCR analysis and the microarray data analysis were consistent (p < 0.05). 24414129 Lnc2Cancer
EL1424 uc003tfx gastric cancer microarray, qPCR etc. primary gastric adenocarcinoma tissue up-regulated N/A For the lncRNAs, the results demonstrated that uc003iqu, uc003tfx, AK022971 and uc.341 were upregulated and that HIV1230, BC011663, AK057054 and M14574 were downregulated in the GC tissues relative to their matched counterparts (all p<0.05). 24819045 Lnc2Cancer
EL1425 AC091173.1 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue up-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL1426 uc004bbl.1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1427 uc004bdv.3 hepatocelluar carcinoma microarray, qPCR etc. HBV-related HCC tissue up-regulated expression Four upregulated lncRNAs were randomly selected and analyzed for their expression levels in tissue samples from 14 HBV-related HCC patients. The corresponding non-tumor tissues were analyzed via qPCR, in which the obtained results are consistent with the microarray data. 26109807 Lnc2Cancer
EL1428 uc009wkz.1 renal cell carcinoma microarray, qPCR etc. RCC tissue up-regulated N/A From five paired samples we identified hundreds of significantly differentiated lncRNAs. Specifically, the most upregulated lncRNAs were: uc001vjj.1, ENST00000414223, BC047917, uc003erl.1, and uc009wkz.1, of which uc001vjj.1 was the highest. The most highly downregulated were: ENST00000507950, uc001aka.2, NR_026860, NR_024256, and BC070168, of which ENST00000507950 showed the largest downregulation. 24905231 Lnc2Cancer
EL1429 uc021re1.1 endometrial cancer microarray, qPCR etc. endometrial carcinoma tissue up-regulated expression The results showed that seven of these lncRNAs were in accordance with microarray data, including three up-regulated lncRNAs (uc003xut., uc021re1.1, ENST00000445734) and four down-regulated ones (uc002nbr.3, ENST00000502941, ENST00000448093, ENST00000503710). 26131074 Lnc2Cancer
EL1431 UCA1 colorectal cancer in vitro and in vivo growth-promoting function two CRC cohorts up-regulated N/A UCA1 could sponge endogenous miR-204-5p and inhibit its activity 27046651
EL1431 UCA1 gastric cancer microarray assay, real-time PCR assay gastric tumor samples N/A expression There was a significantly positive correlation of UCA1 expression levels between tumor tissues and plasma (r = 0.931). Plasma UCA1 provided the higher diagnostic performance for detection of GC (AUC = 0.928; P < 0.001) than PVT-1 (AUC = 0.731; P < 0.01). Plasma UCA1 levels could be a promising candidate of noninvasive biomarker for GC early diagnosis. 26722487
EL1431 UCA1 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL1431 UCA1 breast cancer microarray, qPCR, knockdown, ISH etc. breast cancer tissues and adjacent normal tissues, cell lines(MDA-MB-231) up-regulated interaction UC1 was significantly upregulated, while miR-143 was significantly downregulated in the tumor tissues than in the adjacent normal tissues. There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143. Through downregulating miR-143, UCA1 can modulate breast cancer cell growth and apoptosis 26439035 Lnc2Cancer
EL1431 UCA1 colorectal cancer microarray, qPCR, Luciferase reporter assay, knockdown etc. CRC tissue, cell lines (HCT116, SW480, RKO, HCT8, LoVo etc.) up-regulated interaction UCA1 was upregulated in CRC and the expression of UCA1 was statistically correlated with lymph node metastasis, distant metastasis and tumor stage. We also found that knockdown of UCA1 significantly suppressed cell proliferation and metastasis in CRC cells. Flow cytometry assays showed UCA1 silencing induced G0/G1 growth arrest and apoptosis of CRC cells. To further investigate the regulatory mechanisms of UCA1, we identified that Ets-2 bound to the UCA1 core promoter using luciferase assays. 26238511 Lnc2Cancer
EL1431 UCA1 bladder cancer microarray, qPCR, Northern blot etc. bladder cancer tissue, cell lines (TCC, BLS-211, BLZ-211 etc.) up-regulated expression UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. 18501714 LncRNADisease Lnc2Cancer
EL1431 UCA1 breast cancer microarray, qPCR, Western blot, knockdown, Luciferase reporter assay, RIP etc. cell lines ( MCF-7, MDA-MB-231, HCT-116 p53-WT, HCT-116 etc.) up-regulated regulation Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). 24457952 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer microarray, qPCR, Western blot, Luciferase reporter assay, knockdown etc. bladder cancer tissue, cell lines (RT4, T24 etc.) up-regulated regulation Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. 24495014 LncRNADisease Lnc2Cancer
EL1431 UCA1 prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
EL1431 UCA1 gastric cancer microarray, RT-PCR gastric tumor samples up-regulated expression The expression level of 4 lncRNAs: UCA1, lincRNA-BBOX1-2, CR594506 and BC015134 were further confirmed in another cohort of 10 gastric patients by real-time PCR assay. A coding-non-coding co-expression network revealed that the four validated lncRNAs were correlated with twenty-six mRNAs which gave clues about the potential roles of these lncRNAs in the process of gastric cancer progression. 25769450
EL1431 UCA1 epithelial ovarian cancer N/A EOC tissues and cells up-regulated N/A upregulated in EOC tissues and cells, but also correlated with status of lymph; an endogenous sponge 26867765
EL1431 UCA1 squamous cell carcinoma N/A N/A N/A expression Cancer up-regulated drug resistant (CUDR) gene, was found to be overexpressed in a doxorubicin-resistant subline of human squamous carcinoma A431 and A10A cells. 17416635 LncRNADisease
EL1431 UCA1 pancreaticobiliary maljunction N/A N/A N/A expression Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction. 21593646 LncRNADisease
EL1431 UCA1 bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
EL1431 UCA1 bladder cancer N/A N/A N/A expression Diagnostic marker oncogene 24373479 LncRNADisease
EL1431 UCA1 oral squamous cell carcinoma N/A N/A N/A expression Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA3 in metastasized samples was prominent higher than the non-metastatic samples.? 24817925 LncRNADisease
EL1431 UCA1 tongue squamous cell carcinoma N/A N/A N/A expression Meaningfully, the expression levels of UCA1 lncRNA were dramatically higher in TSCC tissues than those in paired ANTs.? 24817925 LncRNADisease
EL1431 UCA1 urinary bladder cancer N/A N/A N/A N/A UCA1 expression was found in T24 cell line and also found to be significantly higher in the cancer group as compared to the controls 25123267 LncRNADisease
EL1431 UCA1 bladder cancer qPCR etc. bladder cancer tissue up-regulated expression UCA1 was identified as a novel noncoding RNA gene dramatically up-regulated in TCC (bladder transitional cell carcinoma) and it is the most TCC-specific gene yet identified. 16914571 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR etc. cell line (BLZ-211) up-regulated N/A After knocking down of UCA1 in BLZ-211 cells, several cell cycle-related genes (CDKN2B, EP300 and TGFβ-2) were screened by microarray assay and validated by qPCR. Taken together, we concluded that UCA1 regulated cell cycle through CREB via PI3K-AKT dependent pathway in bladder cancer. 22285928 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR etc. bladder cancer tissue up-regulated expression With a high level of sensitivity and specificity, UCA1 is a promising urinary marker for the diagnosis of bladder cancer. 22490897 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR etc. cell lines (BLZ-211, 5637, UM-UC-2 etc.) up-regulated expression Overexpression of UCA1a(CUDR) significantly enhanced proliferation, migration and invasion of the bladder cancer cell line UM-UC-2. 22576688 LncRNADisease Lnc2Cancer
EL1431 UCA1 oral squamous cell carcinoma qPCR etc. OSCC tissues up-regulated N/A We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. 23292713 Lnc2Cancer
EL1431 UCA1 tongue squamous cell carcinoma qPCR etc. TSCC tissue up-regulated N/A The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells. 24332332 Lnc2Cancer
EL1431 UCA1 colorectal cancer qPCR etc. colorectal cancer tissue, cell lines (CaCO-2, SW480, HCT116, LoVo etc.) up-regulated N/A UCA1 levels were markedly increased in CRC tissues, and this high level of UCA1 expression was significantly correlated with larger tumour size, less differentiated histology and greater tumour depth.an important role for UCA1 in the molecular aetiology of CRC and suggest a potential application for UCA1 in CRC diagnosis, progression and therapy. 24977734 Lnc2Cancer
EL1431 UCA1 gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. 25694351 Lnc2Cancer
EL1431 UCA1 gastric cancer qPCR etc. gastric cancer tissue, cell lines (SGC-7901, BGC-823, MKN-28) up-regulated N/A UCA1 expression was remarkably increased in gastric cancer tissues and cell lines compared with that in the normal control; high UCA1 expression correlated with worse differentiation, tumor size, invasion depth and TNM stage in gastric cancer; increased UCA1 expression contributed to poor overall survival and disease-free survival of patients. 25903045 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR etc. urine up-regulated interaction Compared to control groups, the malignant group had higher expression levels of miR-210, miR-96, and lncRNA-UCA1. 26138586 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR etc. urine up-regulated expression The detected lncRNA-UCA1 level was significantly lower in healthy donors and benign groups compared to bladder cancer samples. 26161701 Lnc2Cancer
EL1431 UCA1 lung cancer qPCR etc. NSCLC tissue up-regulated expression The results showed that the expression of UCA1 in NSCLC tissues was obviously higher than that observed in pair-matched adjacent nontumourous tissues, (P < 0.001). In conclusion, the current results indicated that Plasma UCA1 could serve as a potential biomarker for diagnosis of NSCLC. UCA1 as a biomarker in clinical application might significantly improve the efficacy of human NSCLC screening. 26380024 Lnc2Cancer
EL1431 UCA1 breast cancer qPCR etc. breast cancer tissue up-regulated expression We found that treatment with macrophage CM induced the expression of numerous lncRNAs, including urothelial cancer associated 1 (UCA1). Knockdown of UCA1 using shRNA inhibited AKT phosphorylation and abolished invasiveness of tumor cells induced by macrophage CM. Consistent with these results; we further showed that UCA1 level was significantly enhanced in human primary breast tumors and correlated with advanced clinical stage, supporting its role in promoting carcinogenesis and progression of breast cancer 26464647 Lnc2Cancer
EL1431 UCA1 hepatocelluar carcinoma qPCR etc. HCC tissue up-regulated expression We found that lncRNA-UCA1 and lncRNA-WRAP53 were significantly higher in sera of HCC than those with chronic HCV infection or healthy volunteers. Our data suggested that the increased expression of UCA1 and WRAP53 was associated with advanced clinical parameters in HCC. 26551349 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, ISH etc. cell lines (BLS-211, BLX-211, BLZ-211 etc.) up-regulated expression In adult human tissues, UCA1 gene was not expressed except in the heart and spleen. The expression level of UCA1 was increased in 8 common tumor tissues as compared with that in the corresponding normal tissues. 20117985 LncRNADisease Lnc2Cancer
EL1431 UCA1 melanoma qPCR, knockdown etc. melanoma tissue, cell line (A-375) up-regulated N/A highly expressed,can promote the metastasis of melanoma. The expression levels of UCA1 and Malat-1 lncRNAs had the potential to be prognostic indicators in metastasis of melanomas. 24892958 Lnc2Cancer
EL1431 UCA1 esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (EC109, EC9706, KYSE150, KYSE510) up-regulated expression The relative level of UCA1 was significantly higher in ESCC tissues, and remarkably higher expression of UCA1 was found in esophageal cancer cell lines compared with the immortalized esophageal epithelial cell line NE1. The ESCC patients with higher UCA1 expression had an advanced clinical stage and a poorer prognosis than those with lower expression. In vitro assays, our data indicated that downregulation of UCA1 decrease cell proliferation, migration, and invasion ability. 25550835 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Luciferase reporter assays, knockdown etc. cell lines (5637, T24, BLZ-211, BLS-211) up-regulated expression Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis. 24648007 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, in vitro knockdown, RIP etc. bladdder cancer tissue up-regulated N/A In the present study, we first examined the function of UCA1 in 5637 bladder cancer cells, which express high levels of UCA1. We found that UCA1 plays an oncogene-like role in this bladder cancer cell line, which is consistent with previous reports. Furthermore, we found UCA1 promotes 5637 cell proliferation by antagonizing the activities of BRG1, by reducing its binding to the p21 promoter and inhibiting its chromatin remodeling activity.UCA1 impairs both binding of BRG1 to the p21 promoter and chromatin remodeling activity of BRG1. 24993775 Lnc2Cancer
EL1431 UCA1 liver cancer qPCR, Western blot, ISH, RIP, ChIP etc. Human liver cancer stem cell line up-regulated interaction Herein, we demonstrate excessive CUDR cooperates with excessive CyclinD1 or PTEN depletion to accelerate liver cancer stem cells growth and liver stem cell malignant transformation in vitro and in vivo. 26513297 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, knockdown etc. bladder cancer cell lines up-regulated N/A In this study, we show that lncRNA UCA1 promotes glycolysis in bladder cancer cells, and that UCA1-induced hexokinase 2 (HK2) functions as an important mediator in this process. We further show that UCA1 activates mTOR to regulate HK2 through both activation of STAT3 and repression of microRNA143. 24890811 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, knockdown etc. bladder cancer tissue up-regulated N/A Here, we report that downregulated hsa-miR-1 and upregulated lncRNA urothelial cancer associated 1 (UCA1) were inversely expressed in bladder cancer. Hsa-miR-1 decreased the expression of UCA1 in bladder cancer cells in an Ago2-slicer-dependent manner. The binding site between UCA1 and hsa-miR-1 was confirmed. Overexpression of hsa-miR-1 inhibited bladder cancer cell growth, induced apoptosis, and decreased cell motility. hsamiR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer, which may have potential therapeutic significance. 25015192 Lnc2Cancer
EL1431 UCA1 non-small cell lung cancer qPCR, Western blot, knockdown etc. lung adenocarcinoma tissues, cell lines (PC9, H1975, H460, H23, H1299) up-regulated interaction In our study, UCA1 expression was significantly increased in lung cancer cells and patients with acquired resistance to EGFR-TKIs. Over-expression of UCA1 was significantly associated with a shorter progression-free survival (PFS), in tumors with respond to EGFR-TKIs. 26160838 Lnc2Cancer
EL1431 UCA1 prostate cancer qPCR, Western blot, knockdown etc. prostate cancer tissue, cell lines (22RV1, PC3, LNCaP) up-regulated interaction Herein, we found that UCA1 was abnormally upregulated in tumor tissues from PC patients, and patients with high UCA1 levels had a significantly poorer prognosis. Intriguingly, the mRNA and protein levels of KLF4 were significantly increased in tumor tissues, which was highly correlated to UCA1 levels. Moreover, UCA1 depletion inhibited the growth and induced apoptosis in PC3 and LNCaP cell lines. In addition, UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13. Taken together, our study indicated that UCA1 had a crucial role in the tumorigenesis of PC. 26550172 Lnc2Cancer
EL1431 UCA1 hepatocelluar carcinoma qPCR, Western blot, knockdown, RIP etc. HCC tissue, cell lines (MHCC97L, SMMC7721, MHCC97H, HepG2, SK-Hep1 etc.) up-regulated N/A Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. 25760077 LncRNADisease Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, Luciferase reporter assay etc. bladder cancer tissue, cell lines (UMUC2, 5637) up-regulated interaction Real-time reverse transcriptase-polymerase chain reaction demonstrated that the RNA level of urothelial carcinoma-associated 1 and GLS2 was positively correlated in bladder cancer tissues and cell lines. 26373319 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, Luciferase reporter assay etc. bladder cancer tissue, cell lines (5637, T24, UMUC2) up-regulated interaction Here, we demonstrated that overexpression of lncRNA-UCA1 could induce epithelial to mesenchymal transition (EMT) and increase the migratory and invasive abilities of bladder cancer cells. Mechanistically, lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), and regulated bladder cancer cell migration and invasion by tumor suppressive hsa-miR-145 and its target gene the actin-binding protein fascin homologue 1 (FSCN1). 26544536 Lnc2Cancer
EL1431 UCA1 bladder cancer qPCR, Western blot, Luciferase reporter assay, knockdown etc. cell lines (5637, T24) up-regulated N/A LncRNA-UCA1 was upregulated by hypoxia in bladder cancer cells. Under hypoxic conditions, lncRNA-UCA1 upregulation increased cell proliferation, migration, and invasion and inhibited apoptosis. The underlying mechanism of hypoxia-upregulated lncRNA-UCA1 expression was that HIF-1a specifically bound to HREs in the lncRNA-UCA1 promoter. Furthermore, HIF-1a knockdown or inhibition could prevent lncRNA-UCA1 upregulation under hypoxia. 24737584 Lnc2Cancer
EL1431 UCA1 non-small cell lung cancer qPCR, Western blot, Luciferase reporter assay, RIP etc. NSCLC and adjacent non-tumor lung tissues, cell lines (A549, H1299, H446, H460, NCIH1650, BEAS-2B) up-regulated interaction UCA1 overexpression enhanced, whereas UCA1 silencing impaired the proliferation and colony formation of NSCLC cells. Moreover, mechanistic investigations showed that UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p. Overall, we concluded that UCA1 functions as an oncogene in NSCLC, acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p 26655272 Lnc2Cancer
EL1431 UCA1 liver cancer qPCR, Western blot, RIP etc. cells line (MEL-2) up-regulated interaction Herein, we demonstrate that SET1A cooperates with CUDR to accelerate hepatocarcinogenesis and promote malignant transformation of hepatocyte-like stem cells. Mechanistically, CUDR enhances the phosphorylation of RB1, C-myc expression, and the interplay between the SET1A and pRB1. Notably, CUDR acts as a sponge cushion that shows a link between SET1A and pRB1, producing a activated pRB1-SET1A complex. 26581161 Lnc2Cancer
EL1431 UCA1 renal cell carcinoma Quantitative polymerase chain reaction (qPCR RCC cell lines compared with the human embryonic kidney 293T cell line up-regulated N/A an oncogene in RCC 26935146
EL1431 UCA1 gastric cancer quantitative real-time PCR N/A up-regulated N/A Silence of UCA1 could significantly inhibit the cell proliferation of gastric cancer 27056384
EL1431 UCA1 acute myeloid leukemia RNA-seq, qPCR, in vitro knockdown, RIP etc. cell lines(K562 , CEBPA, CEBPA-P30, K562etc.) up-regulated interaction In this study, we identified the oncogenic urothelial carcinoma associated 1 (UCA1) lncRNA as a novel target of the C/EBPα-p30. While wild-type C/EBPα represses, C/EBPα-p30 can induce UCA1 transcription. Notably, we also show that UCA1 expression increases in cytogenetically normal AML cases carrying biallelic CEBPA mutations.Thus, we identified, for the first time, an oncogenic lncRNA functioning in concert with the dominant negative isoform of C/EBPα-p30 in AML. 26053097 Lnc2Cancer
EL1432 UCA1 focal cardiac ischemia reperfusion injury microarray, qPCR primary cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR) down-regulated expression Reduction of UCA1 levels plays a pro-apoptotic role in primary cardiomyocytes partially through stimulation of p27 protein expression. These results are in agreement with the observed levels of UCA1, p27 and apoptosis after cardiac I/R injury, suggesting that UCA1 might have an important role during I/R injury 25871510
EL1433 UCH1LAS Parkinson's disease N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
EL1434 UCHL1-AS1 Parkinson's Disease N/A N/A N/A interaction In Parkinson's Disease the lncRNA UCHL1-AS1 acts by directly promoting translation of UCHL1 protein leading to perturbation of the ubiquitin-proteasome system. 27338628
EL1435 UFC1 hepatocelluar carcinoma microarray, qPCR, in vitro knockdown etc. HCC tissue, cell lines (BEL-7402, SK-Hep1, Huh7, MHCC-97H) up-regulated regulation Levels of the lincRNA-UFC1 were increased in HCC tissues compared with controls, and associated with tumor size, Barcelona Clinic Liver Cancer stage, and patient outcomes. Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effetcs. 25449213 Lnc2Cancer
EL1438 ULK4P2 hepatocelluar carcinoma microarray, qPCR etc. HBV-related HCC tissue up-regulated interaction Four upregulated lncRNAs were randomly selected and analyzed for their expression levels in tissue samples from 14 HBV-related HCC patients. The corresponding non-tumor tissues were analyzed via qPCR, in which the obtained results are consistent with the microarray data. The upregulated large intergenic noncoding RNA ULK4P2 was physically combined with enhancer of zeste homolog 2. Therefore, the lncRNAs may participate in regulating HBV-related HCC. 26109807 Lnc2Cancer
EL1439 URHC hepatocelluar carcinoma microarray, qPCR, Western blot etc. hepatocellular cancer tissue, cell lines (DMEM, Gibco, Gaithersburg, MD, USA etc.) up-regulated N/A We confirmed that URHC expression was up-regulated in 30 HCC cases (57.7%) and that its higher expression was correlated with poor overall survival. We further demonstrated that URHC inhibition reduced cell proliferation and promoted apoptosis. high URHC expression can promote cell proliferation and inhibit apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. 25013376 Lnc2Cancer
EL1443 VIM2P osteoarthritis qPCR,microarray,Western blot, and immunofluorescence analyses OA cartilage and normal cartilage up-regulated interaction LncRNA-CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA. 24757148
EL1444 VL30 LTRs hepatocelluar carcinoma N/A N/A N/A expression Trim24 (Tif1) and Trim33 (Tif1) interact to form a co-repressor complex that suppresses murine hepatocellular carcinoma. Here we show that Trim24 and Trim33 cooperatively repress retinoic acid receptor-dependent activity of VL30-class endogenous retroviruses (ERVs) in liver. In Trim24-knockout hepatocytes, VL30 derepression leads to accumulation of reverse-transcribed VL30 cDNA in the cytoplasm that correlates with activation of the viral-defense interferon responses mimicking the preneoplastic inflammatory state seen in human liver following exogenous viral infection. Furthermore, upon derepression, VL30 long terminal repeats (LTRs) act as promoter and enhancer elements deregulating expression of neighboring genes and generating enhancer RNAs that are required for LTR enhancer activity in hepatocytes in vivo. 23377542 LncRNADisease
EL1446 VLDLR-AS1 hepatocelluar carcinoma qPCR, Western blot, knockdown etc. cell lines (HepG2, Hep3B, PLC/PRF-5, Huh-7) up-regulated N/A lincRNA-VLDLR (linc-VLDLR) was significantly upregulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer agents such as sorafenib, camptothecin, and doxorubicin increased linc-VLDLR expression in cells as well as within EVs released from these cells. Incubation with EVs reduced chemotherapy-induced cell death and also increased linc-VLDLR expression in recipient cells. RNAi-mediated knockdown of linc-VLDLR decreased cell viability and abrogated cell-cycle progression. 24874432 Lnc2Cancer
EL1447 VNN2 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression The remaining 10 lncRNAs, showed significantly different expression in the tumor samples. For 9 of these, expression was altered in the same direction as had been detected by microarray analysis (8 lower, and 1 higher, than NT samples; all p < 0.001; ).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease. 25758555 Lnc2Cancer
EL1448 VPS9D1-AS1 ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (SKOV3, SKOV3.ip1 etc.) down-regulated N/A The qPCR results of seven lncRNAs (MALAT1, H19, UCA1, CCAT1, LOC645249, LOC100128881, and LOC100292680) were consistent with the deregulation found by microarray analysis, reflecting the reliability of the microarray data to some extent. 24379988 Lnc2Cancer
EL1450 VTRNA2-1 gastric cancer RNA-seq, qPCR etc. gastric cancer tissue, gastric cell lines down-regulated N/A Our real-time RT-PCR data (Fig 1A) indicated that the expression level of nc886 was lower in a subpopulation of tumor tissues than in normal tissues. nc886 inhibits cell proliferation when ectopically expressed in gastric cancer cells. 25003254 Lnc2Cancer
EL1451 Wbp1l hypoxic-ischemic brain damage Silencing hypoxic-ischemic (HI) rat brains up-regulated interaction N/A 26349411
EL1453 WISP1 colorectal cancer N/A HCT116, HCT8, and SW480 colorectal cancer cells up-regulated expression AK027294 down-regulation significantly inhibited colorectal cancer cells proliferation and migration, but promoted cell apoptosis (P < 0.05) 26820130
EL1454 WRAP53 dyskeratosis congenita N/A N/A N/A mutation Disruption of telomerase trafficking by WRAP53 mutation causes dyskeratosis congenita. 21205863 LncRNADisease
EL1454 WRAP53 cancer N/A N/A N/A N/A WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. 21368886 LncRNADisease
EL1454 WRAP53 cancer N/A N/A N/A expression A natural antisense transcript of TP53, WRAP53, was strongly augmented by idarubicin and etoposide. 21441950 LncRNADisease
EL1454 WRAP53 hepatocelluar carcinoma qPCR etc. HCC tissue up-regulated expression We found that lncRNA-UCA1 and lncRNA-WRAP53 were significantly higher in sera of HCC than those with chronic HCV infection or healthy volunteers. Our data suggested that the increased expression of UCA1 and WRAP53 was associated with advanced clinical parameters in HCC. 26551349 Lnc2Cancer
EL1455 WSPAR hepatocelluar carcinoma microarray, qPCR, Northern blot, FISH etc. cell lines (Hep3B, Huh7, and PLC) up-regulated interaction Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. 25842979 Lnc2Cancer
EL1455 WSPAR hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay etc. HCC cell lines (SK-Hep-1, BEL-7402) up-regulated interaction We demonstrate that IL-6 could induce lncTCF7 expression in a time- and dose-dependent manner, and we showed that IL-6 transcriptionally activated the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to promoter regions of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduced lncTCF7 expression. Importantly, RNA interference-based attenuation of lncTCF7 prevented IL-6-induced EMT and cell invasion. 26452542 Lnc2Cancer
EL1456 WT1-AS Wilms' tumor N/A renal and haematopoietic cells down-regulated expression Both wt1-as and the novel awt1 transcript are imprinted in normal kidney with expression confined to the paternal allele. 14681303
EL1456 WT1-AS acute myeloid leukemia qPCR etc. bone marrow tissue differential expression epigenetics The incidence of WIT-1 methylation in primary refractory AML was significantly higher than that noted in chemosensitive AML. 10340388 LncRNADisease Lnc2Cancer
EL1456 WT1-AS acute myeloid leukemia qPCR etc. Bone marrow up-regulated Interaction In AML, there is often abnormal splicing of WT1-AS, which may play a role in the development of this malignancy. 17940140 LncRNADisease Lnc2Cancer
EL1456 WT1-AS Wilms' tumor qPCR etc. Bone marrow up-regulated Interaction WT1 is a gene that is mutated in Wilms' tumor (WT) and acute myeloid leukaemia (AML) and has an antisense transcript (WT1-AS), which was found to regulate WT1 protein levels. 17940140 LncRNADisease Lnc2Cancer
EL1456 WT1-AS gastric cancer qPCR etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MKN45, MKN28, NCI-N87, AGS, HS-746T, GES-1) down-regulated expression We found that WT1-AS expression was significantly down-regulated in tumor tissues compared to matched adjacent non-tumor tissues. The WT1-AS expression level was also associated with tumor size and the clinicopathological stage. Cell proliferation, migration, and invasion were inhibited, and the proportion of G0/G1 cells increased when WT1-AS was ectopically-expressed in gastric cancer cells. Furthermore, ectopic expression of WT1-AS was demonstrated to inhibit tumor growth and metastasis in vivo. Finally, we found that WT1-AS overexpression could decrease ERK protein phosphorylation. 26449525 Lnc2Cancer
EL1456 WT1-AS Wilms' tumor qPCR, Southern blot, knockdown etc. Wilms' tumor tissue differential expression epigenetics A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. 17210670 LncRNADisease Lnc2Cancer
EL1456 WT1-AS hepatocelluar carcinoma qPCR, Western blot, Luciferase reporter assay etc. hepatocellular carcinoma tissue down-regulated interaction WT1-AS expression correlated negatively with WT1 expression in HCC tumor tissue. Kaplan-Meier curve analysis revealed that WT1-AS expression is a reliable indicator of HCC prognosis. The downregulation of WT1 expression by WT1-AS promoted cell apoptosis by suppressing the JAK/STAT3 signaling pathway. Bioinformatics analysis showed that WT1-AS downregulates WT1 by binding to the TATA region of the WT1 promotor. WT1-AS was also able to reverse WT1-mediated resistance to Dox based chemotherapy in HCC cells 26462627 Lnc2Cancer
EL1456 WT1-AS Wilms' tumor Southern blot analysis, RT-PCR kidney up-regulated epigenetics Wts display hypomethylation and biallelic expression of wt1-as. 10811108
EL1457 Wt1os ischemia/reperfusion N/A N/A N/A expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. 24312245 LncRNADisease
EL1459 XIST colorectal cancer microarray, FISH etc. CRC tissue differential expression N/A X inactive-specific transcript gene amplification has also been detected in microsatellite-unstable sporadic human CRC tissue when compared to matched normal colorectal epithelium. aCGH revealed distinct DNA copy number changes between sporadic CIN- and MIN-associated colorectal carcinomas. A differential role of these candidate oncogenes and tumor suppressor genes in tumor development and progression of sporadic CIN and MIN CRC is likely and may also be involved in the response or resistance to therapeutic interventions, such as shown for microsatellite instability and 5-FU. 17143621 Lnc2Cancer
EL1459 XIST breast cancer microarray, FISH etc. breast cancer tissue differential expression mutation The intratumoral and intertumoral variability in XIST RNA domain number in BRCA1 tumors correlates with chromosomal genetic abnormalities, including gains, losses, reduplications, and rearrangements of the X-chromosome. 17545591 LncRNADisease Lnc2Cancer
EL1459 XIST ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (ALST, CAOV3, OVCA3 etc.) down-regulated N/A The clinical relevance of this observation is demonstrated by the strong association between XIST RNA levels and disease-free periods of ovarian cancer patients in a group of 21 ovarian cancer cases with Taxol in the therapeutic regiments. Cytogenetic studies on ovarian cancer cell lines indicated that loss of inactive X chromosome is one mechanism for the loss of XIST transcripts in the cell lines. Our data suggest that XIST expression may be a potential marker for chemotherapeutic responses in ovarian cancer. 12492109 Lnc2Cancer
EL1459 XIST ovarian cancer microarray, qPCR etc. ovarian cancer tissue, cell lines (NOSE, EOC etc.) down-regulated N/A A series of malignant ovarian tumor samples were investigated for XIST expression. XIST expression was detectable by RT-PCR in the majority of EOC samples tested but was expressed at very low levels in four of 15 (27%) EOC samples, TOV921G, TOV1118D, TOV837, and TOV1054G. 17143508 Lnc2Cancer
EL1459 XIST renal collecting duct carcinoma microarray, Western blot etc. cell lines (AP3, AP8-CDC etc.) up-regulated N/A In cell lines created from the tissue of both a male patient and a female patient with collecting duct carcinoma of the kidney, the XIST gene, along with several other chromosome X genes, was found to have an increase in copy number. The results suggest that TOP1 might be one of the molecular targets in AP8 CDC cells. Thus, these novel CDC cell lines will be useful for discovering therapeutic targets and developing effective anticancer drugs against CDC. 19154479 Lnc2Cancer
EL1459 XIST Klinefelter's syndrome N/A N/A N/A expression We demonstrated by quantitative RT-PCR an active XIST RNA expression in blood lymphocytes from Klinefelter patients, comparable to that observed in control females and over 30,000-fold greater than in control males. 18854511 LncRNADisease
EL1459 XIST Klinefelter's syndrome N/A N/A N/A epigenetics Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. 19812237 LncRNADisease
EL1459 XIST female cancers N/A N/A N/A expression Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT2: colorectal cancer). 23660942 LncRNADisease
EL1459 XIST bladder cancer N/A N/A N/A regulation Putative diagnostic and prognostic marker 24373479 LncRNADisease
EL1459 XIST cancer N/A N/A N/A regulation Dysfunction of XIST may trigger the chromatin instability and promote caner development. 24757675 LncRNADisease
EL1459 XIST cancer N/A N/A N/A regulation The lncRNA Xist was found to be a potent tumor suppressor of hematologic malignancies?in vivo. 24829860 LncRNADisease
EL1459 XIST testicular germ cell tumor qPCR etc. testicular germ cell tumor tissue, cell lines (Team-2, JKT-1, ITO-II etc.) up-regulated expression XIST expression was common in seminomatous testicular germ cell tumors but not in nonseminomatous testicular germ cell tumors. 12629412 LncRNADisease Lnc2Cancer
EL1459 XIST non-small cell lung cancer qPCR etc. blood (serum), NSCLC tissue up-regulated expression The levels of XIST (P < 0.05) and HIF1A-AS1 (P < 0.05) were significantly increased in tumor tissues or serum from NSCLC patients as compared to those of control group. Moreover, serum levels of XIST and HIF1A-AS1 were significantly decreased after surgical treatment as compared to pre-operative. 26339353 Lnc2Cancer
EL1459 XIST glioblastoma qPCR, Luciferase reporter assay, RIP etc. glioblastoma tissue up-regulated expression Our results proved that XIST expression was up-regulated in glioma tissues and GSCs. Functionally, knockdown of XIST exerted tumor-suppressive functions by reducing cell proliferation, migration and invasion as well as inducing apoptosis. 25578780 Lnc2Cancer
EL1459 XIST cystic fibrosis qRT-PCR bronchial cells isolated from endobronchial brushings obtained from CF and non-CF individuals N/A expression Dysregulation of some of these lncRNAs may play important roles in the chronic infection and inflammation that exists in the lungs of people with CF. 24631641
EL1460 Xist membranous nephropathy N/A N/A N/A N/A Urinary Xist is significantly elevated in urine samples from patients with different types of glomerular nephritis, including MN, compared to normal counterparts. 25157805 LncRNADisease
EL1462 XLOC_000371 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL1464 XLOC_000620 H. pylori-related diseases N/A N/A N/A N/A Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells 25420666 LncRNADisease
EL1474 XLOC_003286 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1475 XLOC_003405 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue up-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1478 XLOC_004122 H. pylori-related diseases N/A N/A N/A N/A Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells 25420666 LncRNADisease
EL1484 XLOC_004562 H. pylori-related diseases N/A N/A N/A N/A Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells 25420666 LncRNADisease
EL1494 XLOC_005912 H. pylori-related diseases N/A N/A N/A N/A Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells 25420666 LncRNADisease
EL1496 XLOC_007697 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL1497 XLOC_008559 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL1499 XLOC_009911 prostate cancer microarray, qPCR, knockdown etc. urine, cell lines (PC3, LNCaP) up-regulated expression We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples and compared them with matched normal tissues. Interestingly, these markers were also successfully detetced in patient urine samples and were found to be up-regulated when compared with normal urine. 25513185 Lnc2Cancer
EL1500 XLOC_010235 gastric cancer microarray, qPCR etc. gastric cancer tissue up-regulated interaction The expression levels of six up-regulated lncRNAs (XLOC_010235, CACNAICAS3, INTS7, AC104699.1, TSNAX-DISC1, and PRSS21) and six down-regulated lncRNAs (RP11-789C1.1, RP11-528G1.2, MYLK-AS1, RP11-643M14.1, GS1-5L10.1, and AP001439.2) were determined by using qPCR. 26045391 Lnc2Cancer
EL1501 XLOC_012255 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1502 XLOC_014172 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated expression We discovered three lncRNA, RP11-160H22.5, XLOC_014172 and LOC149086, which were up-regulated in HCC comparing with the cancer-free controls. RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction and XLOC_014172 and LOC149086 for metastasis prediction in the future. 25714016 Lnc2Cancer
EL1503 XLOC_014388 H. pylori-related diseases N/A N/A N/A N/A Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells 25420666 LncRNADisease
EL1511 XR_250621.1 triple-negative breast cancer microarray, qPCR etc. TNBC tissue up-regulated expression The results demonstrated that lncRNAs NONHSAT125629 and ENST00000503938 were upregulated and that XR_250621.1 and NONHSAT012762 were down-regulated in the tumor samples compared with NT samples. These qPCR results are consistent with the microarray data. 26078338 Lnc2Cancer
EL1514 LOC105373051 non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression we initially identified a number of significant candidate lncRNAs (including GUCY1B2, RP11-385J1.2, AC018865.8, RP11-909N17.3, GNAS-AS1, TUBA4B, Z82214.3, XLOC_000371, AC013264.2 and RP1-317E23.3) and verified the expression of these lncRNAs by RT-qPCR with GAPDH as the reference gene, by calculating the 2-CT values. 25394782 Lnc2Cancer
EL1515 ZEB1-AS1 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
EL1515 ZEB1-AS1 hepatocelluar carcinoma microarray, qPCR, knockdown etc. HCC tissue, cell lines (Huh7, HepG2, etc.) up-regulated interaction We found that ZEB1-AS1 is frequently upregulated in HCC samples, especially in metastatic tumor tissues. ZEB1-AS1 promotes tumor growth and metastasis, acts as an oncogene in HCC. The ZEB1-AS1 gene is located in physical contiguity with ZEB1 and positively regulates the ZEB1 expression. ZEB1 inhibition partially abrogates ZEB1-AS1-induced epithelial to mesenchymal transition (EMT) and cancer metastasis. 26073087 Lnc2Cancer
EL1515 ZEB1-AS1 esophageal squamous cell carcinoma qPCR etc. ESCC tissues and adjacent non-tumor tissues up-regulated expression LNCRNA ZEB1-AS1 was found up-regulated in ESCC tissues compared to adjacent non-tumor tissues. Increased lncRNA ZEB1-AS1 expression was significantly associated with tumor grade, depth of invasion, and lymph node metastasis. Kaplan-Meier analysis revealed that ESCC patients with high ZEB1-AS1 expression had a poorer overall survival and disease-free survival. Furthermore, multivariate analysis suggested that ZEB1-AS1 expression was identified as an independent prognostic factor in patients with ESCC 26617942 Lnc2Cancer
EL1516 ZEB2-AS1 bladder cancer qPCR etc. bladder cancer cell lines (T24, 5637 and J82) up-regulated interaction A long non-coding RNA, ZEB2NAT, was demonstrated to be essential for this TGFβ1-dependent process. ZEB2NAT depletion reversed CAF-CM-induced EMT and invasion of cancer cells, as well as reduced the ZEB2 protein level. Consistently, TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. 26152796 Lnc2Cancer
EL1517 ZFAS1 breast cancer microarray, Northern blot, ISH etc. breast cancer tissue down-regulated expression SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer.ZFAS1 is highly expressed in the mammary gland and is down-regulated in breast tumors compared to normal tissue. ZFAS1 is a putative tumor suppressor gene. 21460236 LncRNADisease Lnc2Cancer
EL1517 ZFAS1 ductal carcinoma N/A N/A N/A expression Human ZFAS1 levels are reduced in ductal carcinoma relative to normal breast tissue. 21460236 LncRNADisease Lnc2Cancer
EL1517 ZFAS1 colorectal cancer qPCR, knockdown, Western blot, Northern blot, RIP, RNA pull-down assay etc. CRC tissue, cell lines ( HCT116+/+ (p53 wild type), HCT116-/- (p53 knockout), HT-29, DLD-1(p53241F), Colo-206, CaCO-2, SW-837, SW-620) up-regulated interaction We determined expression of 83 long non-coding RNAs (lncRNAs) and identified ZFAS1 to be significantly up-regulated in colorectal cancer (CRC) tissue. We observed significant increase in p53 levels and PARP cleavage in CRC cell lines after ZFAS1 silencing indicating increase in apoptosis. Our data suggest that ZFAS1 may function as oncogene in CRC by two main actions: (i) via destabilization of p53 and through (ii) interaction with CDK1/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis. 26506418 Lnc2Cancer
EL1517 ZFAS1 hepatocelluar carcinoma qPCR, Luciferase reporter assay, RIP etc. HCC tissue, cell lines (Huh7, HepG2, etc.) up-regulated interaction ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16. Conversely, ZFAS1 activated ZEB1, MMP14 and MMP16 expression, inhibiting these effects of miR-150. 26069248 Lnc2Cancer
EL1518 ZFAT-AS1 autoimmune disease N/A N/A N/A mutation SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT (ZFAT-AS1), determine susceptibility to autoimmune thyroid disease. 15294872 LncRNADisease
EL1520 Zim3 heart failure N/A N/A N/A expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 13 downregulated in HF hearts as compared with control hearts. 24205036 LncRNADisease
EL1524 ZMAT1 gastric cancer qPCR etc. gastric cancer tissue down-regulated expression We found for the first time that the lncRNA ZMAT1 transcript variant 2 is downregulated in gastric cancer tissues compared with adjacent normal tissues (P<0.001). The expression of ZMAT1 transcript variant 2 was inversely correlated with lymph node metastasis (P<0.05), depth of tumor invasion and tumor node metastasis stage (P<0.05). Univariate and multivariate analyses showed that ZMAT1 transcript variant 2 expression was an independent predictor for overall survival (P<0.05) 26191264 Lnc2Cancer
EL1526 ZNF295-AS1 lung adenocarcinoma microarray, qPCR etc. lung adenocarcinoma tissue down-regulated expression We initially identified a number of interesting candidate lncRNAs for further analysis. Of these, LOC100132354 and RPLP0P2 exhibited the most significantly changed expression in our analysis of 100 pairs of lung adenocarcinoma and normal lung tissue samples. The expression of LOC100132354 was significantly higher in lung adenocarcinoma than in the adjacent tissues, while the expression of RPLP0P2 was significantly lower in lung adenocarcinoma than in the adjacent tissues. 25089627 Lnc2Cancer
EL1527 ZNF350-AS1 hepatocelluar carcinoma microarray, qPCR, RIP, RNA pulldown assay etc. HCC tissue up-regulated N/A AY129027, uc002pyc and DQ786243 were over-expressed in HCC, whereas the expression of AK055007 and AK123790 was decreased. 21769904 Lnc2Cancer
EL1529 ZNF674-AS1 hepatocelluar carcinoma microarray, qPCR etc. HCC tissue up-regulated N/A The results showed that BC017743, ENST00000395084, NR_026591, NR_015378 and NR_024284 were up-regulated and NR_027151, AK056988 and uc003yqb.1 were down-regulated in HCC samples compared with adjacent NT samples. 25025236 Lnc2Cancer
Function (not disease relevant)
ID lncRNA
Name
Method Sample Expression
pattern
Function
type
Description PMID Source
EL0002 1700007L15Rik knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0005 4930570G19Rik knockdown, over-expression N/A N/A interaction In vitro knockdown of the long non-coding RNA resulted in significant down-regulation of Negr1 mRNA expression, NEGR1 protein levels and neurite length whereas over-expression enhanced Negr1 mRNA expression, NEGR1 protein levels and increased neurite length. The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively. 26723899
EL0007 5430416N02Rik knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Mouse RNA was found to interact with a number of chromatin binding protein/complexes in mouse embryonic stem cells including PRC1, PRC2, JARID1B, ESET, SUV39H1, SETD8 and CBX1 with the general pattern being interaction with repressors of gene expression. 21874018
EL0009 6430411K18Rik N/A N/A N/A interaction Several additional mirnas are processed from antipeg11 and that these regulate rtl1/peg11 in trans by guiding risc-mediated cleavage of its mrna. 15854907
EL0011 9530018H14Rik ChIRP-seq, siRNA-mediated reductions E 11 mouse embryos up-regulated interaction Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme. 26633036
EL0026 AC058791.1 strand-specific RNA-seq single radial glia cells up-regulated N/A regulates cell proliferation 27081004
EL0033 Adapt15 methylmeth- anesulfonate and cis-platinum, X-irradiation hamster HA-1 fibroblasts up-regulated expression These rnas may act in concert to protect cells against the damaging effects of oxidative stress. 8638945
EL0033 Adapt15 RT-PCR, knockdown, MTT assay N/A N/A interaction Gadd7 regulates the G1/S checkpoint in response to UV irradiation. 23103768
EL0033 Adapt15 UV radiation, overexpression Chinese hamster ovary (CHO) cells up-regulated expression Overexpression of gadd7 led to a decrease in cell growth. interestingly, gadd7 cdna does not contain an appreciable open reading frame and does not appear to encode a protein product, but instead may function at the rna level. 8649973
EL0040 AFAP1-AS1 N/A hepatocellular carcinoma (HCC) tissues up-regulated expression High AFAP1-AS1 expression was associated with tumor size, TNM stage, vascular invasion, and poor prognosis. Silencing of AFAP1-AS1 significantly reduced cell proliferation, clonal growth, cell migration, and invasion and increased apoptosis in vitro. AFAP1-AS1 silencing markedly reduced tumor growth in a murine allograft model in vivo. 26803513
EL0041 AGAP2-AS1 RNA seq human differentiated endothelial cells up-regulated expression We have identified and functionally characterized 3 novel lncRNAs involved in vertebrate and human cardiovascular development, and we provide a comprehensive transcriptomic roadmap that sheds new light on the molecular mechanisms underlying human embryonic development, mesodermal commitment, and cardiovascular specification. 25739401
EL0043 AIRN N/A N/A N/A expression Air rna is required for silencing. the truncated air allele maintains imprinted expression and methylation of the air promoter, but shows complete loss of silencing of the igf2r/slc22a2/slc22a3 gene cluster on the paternal chromosome. 11845212
EL0044 Airn N/A E6.5 epiblast N/A locus Here we show lineage- and temporal-specific regulation of DNA methylation and histone modifications at the Igf2r/Airn locus correlating with differential establishment of imprinted expression during gastrulation. After gastrulation commences, the locus becomes imprinted in the embryonic lineage with the lncRNA Airn expressed from the paternal allele and Igf2r restricted to maternal allele expression. 25918552
EL0044 Airn N/A mouse placenta up-regulated interaction Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. Genetic ablation of G9a results in nonimprinted, biallelic transcription of Slc22a3. 18988810
EL0060 AK133540 lncRNA microarray brown adipose tissue (BAT) and white adipose tissue (WAT) N/A expression We found that AK142386 and AK133540 may affect adipogenesis and metabolism. Our data indicate that AK142386 and AK133540 may be involved in BAT and WAT development through their target genes Hoxa3 and Acad10. 25472036
EL0069 alncRNA-EC7 Depleting differentiating mouse fetal liver red blood cells N/A N/A alncRNA-EC7, is transcribed from an enhancer and is specifically needed for activation of the neighboring gene encoding BAND 3. 24200680
EL0070 alpha-250 and alpha-280 Tissue culture transfection and cell-free transcription, Electrophoretic mobility shift experiments N/A N/A interaction Alpha-250 and alpha-280 stimulate s14 mrna transcription, whereas free ribosomal protein s14 inhibits it. 7867928
EL0072 alpha-MHC antisense transcripts Northern blot, RT-PCR neonatal rat heart N/A expression In the neonatal heart naturally occurring antisense mrna may play a role in the regulation of mhc expression and, therefore, in the control of the energetical and contractile behaviour of the heart. 9632112
EL0073 Alu lncRNAs Biochemical assays to probe the network of protein-DNA interactions mouse B2 RNA and human Alu RNA N/A interaction We conclude that B2 and Alu RNA prevent Pol II from properly engaging the DNA during closed complex formation, resulting in complexes with an altered conformation that are transcriptionally inert. In the absence of its normal contacts with the promoter, Pol II is likely held in these inactive complexes on DNA through interactions with promoter-bound TATA box-binding protein and transcription factor IIB. 19307572
EL0074 Ancr-1 RNA fluorescent in situ hybridization, cDNA cloning cortex N/A expression Ancr-1 is involved in diverse organ functions. 15208441
EL0075 antisense TGF beta 3 N/A chick heart N/A expression The temporally controlled appearance of rna complementary to tgf beta 3 suggests that this molecule may play a role in the regulation of tgf beta 3 production in the heart. 1511174
EL0080 APOA1-AS Chromatin immunoprecipitation (ChIP) analyses, Targeting APOA1-AS with short antisense oligonucleotides human and monkey liver cells down-regulated N/A acts as a negative transcriptional regulator of APOA1 both in vitro and in vivo. Inhibition of APOA1-AS in cultured cells resulted in the increased expression of APOA1 and two neighboring genes in the APO cluster. 24388749
EL0081 APOLO RT-PCR/RT-qPCR Auxin-controlled development down-regulated N/A The Arabidopsis long intergenic noncoding RNA (lincRNA) APOLO is transcribed by RNA polymerases II and V in response to auxin, a phytohormone controlling numerous facets of plant development. This dual APOLO transcription regulates the formation of a chromatin loop encompassing the promoter of its neighboring gene PID, a key regulator of polar auxin transport. 25018019 PLNlncRbase
EL0086 ASAR6 N/A N/A N/A N/A Disruption of the large non-coding RNA gene ASAR6 results in ate replication, an under-condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono-allelic expression and asynchronous replication timing. 22706734
EL0087 ASAR6 Disruption of ASAR6 N/A N/A N/A Disruption of ASAR6 leads to the formation of bridged chromosomes, micronuclei, and structural instability of chromosome 6 23593023
EL0088 ASCO-RNA qRT-PCR leaves up-regulated N/A Double Atnsr mutants and ASCO overexpressors exhibit an altered ability to form LRs after auxin treatment. Interestingly, auxin induces a major change in AS patterns of many genes, a response largely dependent on NSRs. RNA immunoprecipitation assays demonstrate that AtNSRs interact not only with their alternatively spliced mRNA targets but also with the ASCO-RNA in vivo. The ASCO-RNA displaces an AS target from an NSR-containing complex in vitro. Expression of ASCO-RNA(lnc351) in Arabidopsis affects the splicing patterns of several NSR-regulated mRNA targets. Hence, lncRNA can hijack nuclear AS regulators to modulate AS patterns during development. Plants overexpressing the ASCO-RNA showed changes in isoform distribution of the auxin-related protein (At2G33830). (Bardou et al., 2014) Expression of the lncRNA ASCO-RNA do not promote lateral root growth. The lncRNA does not cause NSR relocalization but alters NSR activity through direct binding to NSRs and displacement of them from their mRNA targets. In other words, ASCO-RNA prevents the effects of NSRs on the regulation of alternative splicing in their transcript targets. ASCO-RNA overexpression in live plants duplicates the morphological effects observed in the nsra/nsrbdouble mutant, i.e., a decreased lateral root density when plants are grown on auxin. (Kornblihtt et al., 2014) 25073154, 25073153 PLNlncRbase
EL0089 asHSFB2a qRT-PCR/Southern blot hybridization gametophyte development up-regulated N/A HSFB2a expression was counteracted by a natural long non-coding antisense RNA, asHSFB2a. In leaves, the antisense RNA gene is only expressed after heat stress and dependent on the activity of HSFA1a/HSFA1b. HSFB2a and asHSFB2a RNAs were also present in the absence of heat stress in the female gametophyte. Transgenic overexpression of HSFB2a resulted in a complete knock down of the asHSFB2a expression. Conversely, asHSFB2a overexpression leads to the absence of HSFB2a RNA. The knockdown of HSFB2a by asHSFB2a correlated with an improved, knockdown of asHSFB2a by HSFB2a overexpression with an impaired biomass production early in vegetative development. In both cases the development of female gametophytes was impaired. 24874772 PLNlncRbase
EL0091 ASL RT-PCR vernalization down-regulated N/A Furthermore, AtRRP6L1 physically associates with the ASL transcript and directly interacts with the FLC locus. We propose that AtRRP6L proteins participate in the maintenance of H3K27me3 at FLC via regulating ASL. Furthermore, AtRRP6Ls might participate in multiple FLC silencing pathways by regulating diverse antisense RNAs derived from the FLC locus. 25211139 PLNlncRbase
EL0095 AT102202 Microarrays, RT-PCR cultured human liver (HepG2) hepatocytes treated with epigallocatechin-3-gallate( EGCG) up-regulated expression Using a real-time polymerase chain reaction technique, we confirmed that EGCG down-regulated mRNA expression level of the HMGCR and up-regulated expression of AT102202. After AT102202 knockdown in HepG2, weobserved that the level of HMGCR expression was significantly increased relative to the scrambled small interfering RNA control (P < 0.05). 25563320
EL0096 AT1G04425 qRT-PCR/RT-PCR heat and highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G04425 is downregulated by heat and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0097 AT1G10682 qRT-PCR/RT-PCR heat and highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G10682 is downregulated by heat and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0098 AT1G11175 qRT-PCR/RT-PCR cold/salt down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G11175 is downregulated by cold stress and upregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0099 AT1G11185 qRT-PCR/RT-PCR drought and salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, and lncRNA AT1G11185 is upregulated by drought and salt stresses. (details are listed in Appendix S2) 25256571 PLNlncRbase
EL0100 AT1G13448 qRT-PCR/RT-PCR cold, highlight and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, and lncRNA AT1G13448 is downregulated by cold/highlight/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0101 AT1G15002 qRT-PCR/RT-PCR heat/cold down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT1G15002 is upregulated by cold/highlight stresses and downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0102 AT1G15175 qRT-PCR/RT-PCR cold, heat and highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT1G15175 is downregulated by cold/heat/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0103 AT1G15405 qRT-PCR/RT-PCR highlight/salt down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G15405 is upregulated by salt stress and downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0104 AT1G16635 qRT-PCR/RT-PCR cold and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G16635 is upregulated by cold/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0105 AT1G18745 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G18745 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0106 AT1G21529 qRT-PCR/RT-PCR heat up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G21529 is upregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0107 AT1G26208 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G26208 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0108 AT1G26558 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, AT1G26558 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0109 AT1G31935 qRT-PCR/RT-PCR heat and highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G31935 is downregulated by heat and highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0110 AT1G34418 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G34418 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0111 AT1G43765 qRT-PCR/RT-PCR drought up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G43765 is upregulated by drought stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0112 AT1G46554 qRT-PCR/RT-PCR drought/heat down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G46554 is upregulated by drought stress and downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0113 AT1G57835 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G57835 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0114 AT1G58590 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G58590 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0115 AT1G64618 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G64618 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0116 AT1G67105 qRT-PCR/RT-PCR drought and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G67105 is upregulated by drought and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0117 AT1G67365 qRT-PCR/RT-PCR drought, heat and salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G67365 is upregulated by drought, heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0118 AT1G69252 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G69252 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0119 AT1G70518 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G70518 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0120 AT1G74205 qRT-PCR/RT-PCR cold, drought and heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT1G74205 is downregulated by cold/drought/heat stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0121 At1NC018710 qRT-PCR/RNA-seq roots up-regulated N/A Figure 3. Expression Profiles of lincRNAs in Different Arabidopsis Plant Organs and in Response to Biotic and Abiotic Stresses. 23136377 PLNlncRbase
EL0122 AT1TU075330 qRT-PCR light up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0123 AT1TU099900 qRT-PCR light up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0124 AT2G01422 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G01422 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0125 AT2G06002 qRT-PCR/RT-PCR cold, drought, heat, highlight and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G06002 is downregulated by cold/drought/heat/highlight/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0126 AT2G09795 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G09795 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0127 AT2G14878 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G14878 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0128 AT2G15292 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G15292 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0129 AT2G15555 qRT-PCR/RT-PCR drought and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G15555 is upregulated by drought and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0130 AT2G18735 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G18735 is downregulated by heat stress and upregulated by drought and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0131 AT2G26355 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G26355 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0132 AT2G31585 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G31585 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0133 AT2G32315 qRT-PCR/RT-PCR drought up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G32315 is upregulated by drought stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0134 AT2G32795 qRT-PCR/RT-PCR cold and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G32795 is downregulated by cold/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0135 AT2G41178 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G41178 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0136 AT2G41312 qRT-PCR/RT-PCR cold and heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G41312 is downregulated by cold and heat stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0137 AT2G42388 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G42388 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0138 AT2G42485 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G42485 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0139 AT2G43375 qRT-PCR/RT-PCR highlight/salt down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G43375 is upregulated by highlight stress and downregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0140 AT2G44798 qRT-PCR/RT-PCR drought and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G44798 is upregulated by drought and highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0141 AT2G44995 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G44995 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0142 AT2G45023 qRT-PCR/RT-PCR drought, heat and highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G45023 is downregulated by drought/heat/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0143 AT2G45245 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G45245 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0144 AT2G46192 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT2G46192 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0145 At2NC044550 qRT-PCR/RNA-seq leaves up-regulated N/A Figure 3. Expression Profiles of lincRNAs in Different Arabidopsis Plant Organs and in Response to Biotic and Abiotic Stresses. 23136377 PLNlncRbase
EL0146 AT2TU076050 qRT-PCR hypocotyls up-regulated N/A The majority of light-regulated NAT pairs at the two time points were different suggesting amplification of light signal and utilization of specific NAT pairs in short and long term light response. For example, SPA1, which encodes a light signaling repressor, was up-regulated more than eight times after 1h of light treatment in cotyledons. Its concordant antisense transcript, AT2TU076050, was also up-regulated more than four times at the same time point and in the same organ. Neither showed such strong induction at the other time point or organs. 24402519 PLNlncRbase
EL0147 AT2TU077810 qRT-PCR hypocotyls up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0148 AT3G04485 qRT-PCR/RT-PCR drought, heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G04485 is downregulated by drought/heat/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0149 AT3G06125 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G06125 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0150 AT3G07215 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G07215 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0151 AT3G13277 qRT-PCR/RT-PCR highlight/cold down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G13277 is upregulated by highlight stress and downregulated by cold and heat stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0152 AT3G27884 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G27884 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0153 AT3G27990 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G27990 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0154 AT3G29644 qRT-PCR/RT-PCR highlight and salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G29644 is upregulated by highlight and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0155 AT3G44798 qRT-PCR/RT-PCR salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G44798 is upregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0156 AT3G45638 qRT-PCR/RT-PCR cold up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G45638 is upregulated by cold stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0157 AT3G48115 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G48115 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0158 AT3G52072 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions,and lncRNA AT3G52072 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0159 AT3G52742 qRT-PCR/RT-PCR cold, drought and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G52742 is upregulated by cold/drought/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0160 AT3G52748 qRT-PCR/RT-PCR salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G52748 is downregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0161 AT3G54366 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G54366 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0162 AT3G57157 qRT-PCR/RT-PCR heat/highlight down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G57157 is upregulated by highlight stress and downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0163 AT3G59765 qRT-PCR/RT-PCR drought, heat, highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G59765 is downregulated by drought/heat/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0164 AT3G60972 qRT-PCR/RT-PCR drought up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G60972 is upregulated by drought stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0165 AT3G61198 qRT-PCR/RT-PCR cold down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT3G61198 is downregulated by cold stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0166 AT3TU028510 qRT-PCR hypocotyls up-regulated N/A The majority of light-regulated NAT pairs at the two time points were different suggesting amplification of light signal and utilization of specific NAT pairs in short and long term light response. For example, SPA1, which encodes a light signaling repressor, was up-regulated more than eight times after 1 h of light treatment in cotyledons. Its concordant antisense transcript, AT2TU076050,was also up-regulated more than four times at the same time point and in the same organ. Neither showed such strong induction at the other time point or organs. Another example is HYH, a homolog of HY5, and its concordant NAT, AT3TU028510. At 1h, both HYH and AT3TU028510 were significantly induced in hypocotyls only; they were further induced at 6h in roots as well as hypocotyls. 24402519 PLNlncRbase
EL0167 AT3TU075200 qRT-PCR hypocotyls up-regulated N/A Genes coding for transcription factors were significantly over-represented after 1h of white light, whereas metabolism-related genes were over-represented after 6h of white light. For example, an mRNA coding the phototropic-responsive NPH3 family protein, AT3G49970, was specifically down-regulated in hypocotyls after 1h light accompanied by its up-regulated lncNAT, AT3TU075200. 24402519 PLNlncRbase
EL0168 At4 RT-PCR roots up-regulated N/A Loss of At4 lead to increased shoot Pi content and an increase in the shoot: root Pi ratio under low Pi conditions suggesting At4 affects Pi distribution and plant growth. (Shin et al., 2006) In Arabidopsis, the induced expression of ncRNAs of the IPS1/At4 family during phosphate starvation responses results in the accumulation of the PHO2 mRNA,a target of miR399 (micro-RNA 399). showed that a conserved motif of 23 nt in this ncRNA family is complementary to miR399 but has critical mismatches at positions. Therefore, IPS1/At4 RNAs are not cleaved by miR399 but instead sequester miR399 to inhibit its effect on PHO2 mRNA, in a mechanism known as target mimicry. PHO2 RNA encodes an E2 ubiquitin conjugase-related protein that negatively affects shoot phosphate content and remobilization in an unknown mechanism. (Au et al., 2011) The Arabidopsis pho1 mutant is impaired in its ability to load Pi into the xylem and therefore to translocate Pi to the shoot. At4 transcripts were abundant in pho1 plants receiving both low-Pi and high-Pi fertilizer. These results were observed in two independent experiments. Thus, the At4 transcript is not down-regulated in response to Pi in the pho1 mutant, suggesting that down-regulation is dependent on the translocation of Pi to the shoot. (Burleigh et al., 1999) At4 was designated as the TPSI1/Mt4 family because of their common characteristics. They are up-regulated by P limitation and rapidly down-regulated by supply of P or colonization of mycorrhizal fungi. This fact indicates the possibility that they have an important role on the strategies for low P adaptation, although their physiological function is not still clarified. (Jun et al., 2003) 16460506, 21525783, 9880366 PLNlncRbase
EL0169 At4-1 Northern blot/RT-PCR roots up-regulated N/A We also tested the effects of overexpressing a close IPS1 paralog, At4. As with IPS1I, At4 overexpression also resulted in decreased shoot Pi accumulation (Supplementary Fig. 4a online). This finding suggests redundancy between IPS1 and At4 and possibly among the other IPS1 family members, all of which are responsive to Pi starvation and contain a region of miR-399 complementarity (Supplementary Fig. 1). (Franco-Zorrilla et al., 2007) The second regulatory mechanism of lncRNAs in plants might work as a decoy of miRNAs, these kind of lncRNAs exert their functions by binding miRNAs in a target mimicry mechanism to sequestrate the miRNAs’ regulation roles on their target genes, such as lncRNAs IPS1 and at4. IPS1 is complementary to miR399, but contains a mismatch loop which makes it uncleavable when miR399 binding. It is induced by phosphate starvation in plants, and then allows the increased expression of miR399 targets including PHO2, consequently alters shoot phosphate content. IPS1 has many family members in a number of plant species, including At4, At4-1, At4-2 and At4-3 in Arabidopsis thaliana. At4 appears to be functionally redundant with IPS1, overexpression of one of them could result in the same phenotypic change as that when overexpressing both At4 and IPS1. (Zhang et al., 2013) 17643101, 23726911 PLNlncRbase
EL0170 At4-2 Northern blot/RT-PCR roots up-regulated N/A We also tested the effects of overexpressing a close IPS1 paralog, At4. As with IPS1I, At4 overexpression also resulted in decreased shoot Pi accumulation (Supplementary Fig. 4a online). This finding suggests redundancy between IPS1 and At4 and possibly among the other IPS1 family members, all of which are responsive to Pi starvation and contain a region of miR-399 complementarity (Supplementary Fig. 1). (Franco-Zorrilla et al., 2007) The second regulatory mechanism of lncRNAs in plants might work as a decoy of miRNAs, these kind of lncRNAs exert their functions by binding miRNAs in a target mimicry mechanism to sequestrate the miRNAs’ regulation roles on their target genes, such as lncRNAs IPS1 and at4. IPS1 is complementary to miR399, but contains a mismatch loop which makes it uncleavable when miR399 binding. It is induced by phosphate starvation in plants, and then allows the increased expression of miR399 targets including PHO2, consequently alters shoot phosphate content. IPS1 has many family members in a number of plant species, including At4, At4-1, At4-2 and At4-3 in Arabidopsis thaliana. At4 appears to be functionally redundant with IPS1, overexpression of one of them could result in the same phenotypic change as that when overexpressing both At4 and IPS1. (Zhang et al., 2013) 17643101, 23726911 PLNlncRbase
EL0171 At4-3 Northern blot/RT-PCR roots up-regulated N/A We also tested the effects of overexpressing a close IPS1 paralog, At4. As with IPS1I, At4 overexpression also resulted in decreased shoot Pi accumulation (Supplementary Fig. 4a online). This finding suggests redundancy between IPS1 and At4 and possibly among the other IPS1 family members, all of which are responsive to Pi starvation and contain a region of miR-399 complementarity (Supplementary Fig. 1). (Franco-Zorrilla et al., 2007) The second regulatory mechanism of lncRNAs in plants might work as a decoy of miRNAs, these kind of lncRNAs exert their functions by binding miRNAs in a target mimicry mechanism to sequestrate the miRNAs’ regulation roles on their target genes, such as lncRNAs IPS1 and at4. IPS1 is complementary to miR399, but contains a mismatch loop which makes it uncleavable when miR399 binding. It is induced by phosphate starvation in plants, and then allows the increased expression of miR399 targets including PHO2, consequently alters shoot phosphate content. IPS1 has many family members in a number of plant species, including At4, At4-1, At4-2 and At4-3 in Arabidopsis thaliana. At4 appears to be functionally redundant with IPS1, overexpression of one of them could result in the same phenotypic change as that when overexpressing both At4 and IPS1. (Zhang et al., 2013) 17643101, 23726911 PLNlncRbase
EL0172 AT4G01533 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G01533 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0173 AT4G01593 qRT-PCR/RT-PCR cold, heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G01593 is downregulated by cold and heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0174 AT4G02005 qRT-PCR/RT-PCR salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G02005 is downregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0175 AT4G03811 qRT-PCR/RT-PCR salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G03811 is upregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0176 AT4G06701 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G06701 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0177 AT4G08035 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G08035 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0178 AT4G13495 qRT-PCR/RT-PCR heat, highlight, salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G13495 is downregulated by heat/highlight/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0179 AT4G14548 qRT-PCR/RT-PCR drought, salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G14548 is downregulated by drought and salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0180 AT4G15242 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G15242 is upregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0181 AT4G20362 qRT-PCR hypocotyls down-regulated N/A We also found 766 light-responsive discordant NAT pairs (Figure 3B&E and Supplemental Figure9). Here, the large number of light-responsive, discordant NAT pairs that were identified suggested a potentially widespread occurrence of negative regulation by NATs. 24402519 PLNlncRbase
EL0182 AT4G30975 qRT-PCR/RT-PCR salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G30975 is downregulated by salt stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0183 AT4G36648 qRT-PCR/RT-PCR heat down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G36648 is downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0184 AT4G38932 qRT-PCR/RT-PCR salt/cold and higlight down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G38932 is upregulated by salt stress and downregulated by cold/highlight stresses .(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0185 AT4G40065 qRT-PCR/RT-PCR heat/highlight down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT4G40065 is upregulated by highlight stress and downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0186 At4NC047210 qRT-PCR/RNA-seq flowers up-regulated N/A Figure 3. Expression Profiles of lincRNAs in Different Arabidopsis Plant Organs and in Response to Biotic and Abiotic Stresses. 23136377 PLNlncRbase
EL0187 AT4TU030900 qRT-PCR hypocotyls up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0188 AT4TU034830 qRT-PCR hypocotyls up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0189 AT5G01175 qRT-PCR/RT-PCR cold up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G01175 is upregulated by cold stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0190 AT5G03285 qRT-PCR/RT-PCR cold/heat down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G03285 is upregulated by heat stress and downregulated by cold.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0191 AT5G06165 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G06165 is upregulated highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0192 AT5G07322 qRT-PCR/RT-PCR drought, highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G07322 is downregulated by drought/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0193 AT5G15022 qRT-PCR/RT-PCR highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G15022 is upregulated highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0194 AT5G23410 qRT-PCR/RT-PCR heat/drought down-regulated/up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G23410 is upregulated by drought stress and downregulated by heat stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0195 AT5G24735 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G24735 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0196 AT5G40316 qRT-PCR/RT-PCR highlight, salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G40316 is upregulated by highlight/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0197 AT5G43403 qRT-PCR/RT-PCR drought, highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G43403 is upregulated by drought/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0198 AT5G43725 qRT-PCR/RT-PCR heat, salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G43725 is downregulated by heat/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0199 AT5G44569 qRT-PCR/RT-PCR drought/salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G44569 is upregulated by drought/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0200 AT5G48412 qRT-PCR/RT-PCR highlight down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G48412 is downregulated by highlight stress.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0201 AT5G50190 qRT-PCR/RT-PCR drought, highlight, salt up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT5G50190 is upregulated by drought/highlight/salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0202 At5NC025190 qRT-PCR/RNA-seq drought and ABA up-regulated N/A The expression of four representative lincRNAs by qRT-PCR (see Supplemental Figure 12 online). All of the four lincRNAs showed similar induction pattern during drought stress or ABA treatment. 23136377 PLNlncRbase
EL0203 At5NC029980 qRT-PCR/RNA-seq drought and ABA up-regulated N/A The expression of four representative lincRNAs by qRT-PCR (see Supplemental Figure 12 online). All of the four lincRNAs showed similar induction pattern during drought stress or ABA treatment. 23136377 PLNlncRbase
EL0204 At5NC055270 qRT-PCR/RNA-seq drought and ABA up-regulated N/A The expression of four representative lincRNAs by qRT-PCR (see Supplemental Figure 12 online). All of the four lincRNAs showed similar induction pattern during drought stress or ABA treatment. 23136377 PLNlncRbase
EL0205 At5NC056820 qRT-PCR/RNA-seq flowers up-regulated N/A Detection and experimental verification of At5NC056820, a predicted lincRNA. Expression levels are given with SD bars (n = 3). Note that At5NC056820 was highly induced by elf18 and moderately induced by ABA and drought treatment. 23136377 PLNlncRbase
EL0206 AT5TU062110 qRT-PCR hypocotyls up-regulated N/A Our qRT-PCR results confirmed that some lncNATs were significantly regulated by light and their expression profiles were also consistent with the results from ATH NAT arrays (Figure 2 C-F, Supplemental Figure 8 and Supplemental Table 3). 24402519 PLNlncRbase
EL0207 AtCR20-1 microarray, qRT-PCR cytokinins/phosphate starvation down-regulated/up-regulated N/A AtCR20-1 is regulated by biotic (down-regulated by cytokinins) and abiotic (up-regulated by phosphate starvation) signals. AtGUT15 and AtCR20-1 comprise two members of a family of genes that lack a long ORF. 11706161 PLNlncRbase
EL0208 AtGUT15 microarray, qRT-PCR seeds up-regulated N/A AtGUT15 is regulated by biotic (down-regulated by cytokinins) and abiotic (up-regulated by phosphate starvation) signals. AtGUT15 and AtCR20-1 comprise two members of a family of genes that lack a long ORF. 11706161 PLNlncRbase
EL0211 AtR18 RT-PCR hypoxic stress down-regulated N/A A specific Pol III-derived ncRNA (AtR18) responded negatively to hypoxic stress and this regulation was evidently different from that of U6 snRNA. Specifically, AtR18 was not processed into a smaller fragment and no small open reading frames (sORFs) were included. 24252906 PLNlncRbase
EL0212 AtR18 RT-PCR hypoxic stress down-regulated N/A AtR18, transcribed by RNA polymerase III (Pol III), were identified by efficient in vitro transcription in tobacco nuclear extracts. 24914100 PLNlncRbase
EL0213 AtR8 RT-PCR roots and cytosol of cultured cells down-regulated N/A A root-specific AtR8 RNA was found in Arabidopsis. AtR8 RNA was observed in the plant roots and cytosol of cultured cells. The RNA was not processed into a smaller fragment and no short open reading frame was included. AtR8 RNA are transcribed by Pol III and not by Pol II. The expression of the AtR8 RNA responded negatively to hypoxic stress, and this regulation evidently differed from that of U6 snRNA. AtR8 RNA expression respond to hypoxic stress. The AtR8 RNA levels gradually declined under the hypoxic conditions. 22336715 PLNlncRbase
EL0214 AtR8 RT-PCR hypoxic stress down-regulated N/A AtR8, transcribed by RNA polymerase III (Pol III), were identified by efficient in vitro transcription in tobacco nuclear extracts. 24914100 PLNlncRbase
EL0222 B2 SINE RNA electrophoretic mobility shift assays plasmids N/A interaction In vitro B2 RNA assembles into preinitiation complexes on promoter DNA via its interaction with the polymerase, thus rendering the complexes inactive. 17307818
EL0222 B2 SINE RNA N/A N/A N/A epigenetics miR-468-mediated suppression of LSH leads to aberrant methylation of LINE1 and SINE B2. 19959559 LncRNADisease
EL0223 B4GALT1-AS1 cap analysis of gene expression (CAGE) normal and malignant tissues N/A interaction We identified at 5'-end of B4GALT1 a 1.454 kb sequence forming a transcription regulatory region, referred to by us as the TR1-PE1, had all characteristics of a bidirectional promoter directing the transcription of B4GALT1 in a divergent manner along with its long non-coding RNA (lncRNA) antisense counterpart B4GALT1-AS1. The five lncRNA B4GALT1-AS1 transcripts showed significant complementarity with B4GALT1 mRNA. 26315939
EL0234 Bc1 Biochemical experiments nerve cells N/A interaction Bc1-mediated repression targets translation at the level of initiation. specifically, bc1 rna inhibited formation of the 48s preinitiation complex 12451124
EL0234 Bc1 eliminate the BC1 RNA gene N/A N/A expression The lack of bc1 rna appears to reduce exploratory activity. 12944471
EL0234 Bc1 N/A N/A N/A interaction Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
EL0234 Bc1 N/A controls and knockout mice N/A expression The neuron-specific non-messenger bc1 rna contributes to the aptive modulation of behaviour. 15302134
EL0234 Bc1 N/A rabbit reticulocyte lysate system, HeLa cells N/A interaction In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
EL0234 Bc1 Western-blot Oocytes N/A interaction Interactions of this domain with eukaryotic initiation factor 4A and poly(A) binding protein mediate repression;BC1 RNA modulates translation-dependent processes in neurons and germs cells by directly interacting with translation initiation factors. 16330711
EL0236 BcMF11 RT-PCR pollen development up-regulated N/A A 828-bp full-length cDNA of BcMF11, a novel pollen-specific non-coding mRNA-like gene from Chinese cabbage. Antisense RNA transgenic plants displayed decreasing expression of BcMF11 and showed distinct morphological defects. Pollen germination test in vitro and in vivo of the transgenic plants suggested that inhibition of BcMF11 decreased pollen germination efficiency and delayed the pollen tubes’ extension in the style. Under scanning electron microscopy, many shrunken and collapsed pollen grains were detected in the antisense BcMF11 transgenic Chinese cabbage. Further cytological observation revealed abnormal pollen development process in transgenic plants, including delayed degradation of tapetum, asynchronous separation of microspore, and aborted development of pollen grain. These results suggest that BcMF11, as a non-coding RNA, plays an essential role in pollen development and male fertility. RT-PCR and Northern blotting analyses showed that BcMF11 was transcribed at most stages of pollen development. These results suggested that the BcMF11 is a novel non-coding RNA involved in pollen development of Chinese cabbage. (Song et al., 2013) The BcMF11 cDNA has a total length of 828 bp with poly (A) tail. Analysis of the sequence demonstrated that BcMF11 is a novel non-coding RNA which has no prominent open reading frame (ORF) or coding capacity. Transcription analysis indicated that BcMF11 is a novel pollen-specific ncRNA and may be involved in the pollen development of Chinese cabbage. BcMF11 was expressed in developing flower buds, flowers and anthers at a high level, but was not detected in roots, stems, leaves, pistils and developing siliques. Identical expression patterns were also showed in RT-PCR analysis. This indicated BcMF11 is a pollen-preferential expressed gene in Chinese cabbage. (Song et al., 2007) 23064614, 17207554 PLNlncRbase
EL0237 BCYRN1 BC200 truncations and RNase footprinting assays, pull-down assays N/A N/A interaction Tests performed to assess whether BC200 interferes with RHAU helicase activity have demonstrated the ability of BC200 to act as an acceptor of unwound quadruplexes via a cytosine-rich region near the 3'-end of the RNA. RHAU may direct BC200 to bind and exert regulatory functions at quadruplex-containing RNA or DNA sequences. 26740632
EL0237 BCYRN1 N/A N/A N/A interaction Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
EL0237 BCYRN1 N/A rabbit reticulocyte lysate system, HeLa cells N/A interaction In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
EL0237 BCYRN1 N/A N/A N/A expression In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains. 17553964 LncRNADisease
EL0237 BCYRN1 N/A N/A N/A interaction A protein that binds bc200 rna in vivo is immunoreactive with antibodies against srp9. 9605471
EL0237 BCYRN1 transgenic transgenic mice N/A expression when all upstream regions of the G22 gene were removed, expression was completely abolished, despite the presence of intact internal RNA polymerase III promoter elements 17175535
EL0241 bft N/A N/A N/A expression Bft acts downstream of cut and tramtrack to implement correct bristle morphogenesis. 12019237
EL0247 Borg In situ hybridization,RT-PCR N/A N/A expression Nuclear localization of BORG was mediated through a novel RNA motif consisting of the pentamer sequence AGCCC with sequence restrictions at positions -8 (T or A) and -3 (G or C) relative to the first nucleotide of the pentamer. 24732794
EL0247 Borg N/A C2C12 mouse myoblast cell line N/A expression The transcript of borg lacks any extensive open reading frames and contains a cluster of multiple interspersed repetitive sequences in its middle part. 9642273
EL0249 BRCA1 knockdown human fibroblast cells N/A expression Gene expression analysis after RNAi treatment targeted against DDSR1 revealed 119 genes that show differential expression. 26697398
EL0249 BRCA1 microarray, qRT-PCR N/A N/A interaction Loss of DDSR1 impairs cell proliferation and DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant accumulation of BRCA1 and RAP80 at DSB sites. 26411689
EL0262 C730029A08Rik knockdown N/A N/A interaction Blnc1 promotes brown and beige adipocyte differentiation and function 25002143
EL0263 C730036E19Rik knockdown mouse liver up-regulated expression These data support a model in which lncLSTR regulates a TDP-43/FXR/apoC2-dependent pathway to maintain systemic lipid homeostasis. 25738460
EL0270 CARs sequencing, Northern hybridization, ChRIP, qPCR, RACE, siRNA transfection human fibroblast (HF) cells N/A N/A regulates gene expression of neighboring genes through modulating the chromatin structure in cis. 20404130
EL0284 CCLS96.1 RT-PCR/Northern blot flower buds up-regulated N/A A 1.8-kb transcript was observed not only in male flower buds but also in female flower buds. The hybridization signal of CCLS96.1 in the Northern blot analysis was so week that semi-quantitative RT-PCR was performed to analyze the expression patterns of CCLS96.1. CCLS96.1 was expressed also in male and female leaves.In the male plant, the expression of CCLS96.1 in flower buds was 2.67-to 3.42-fold higher than that in leaves. In contrast, in the female plant, the expression of CCLS96.1 in flower buds was 0.06-to 0.19-fold less than that in leaves. This suggests that the CCLS96.1 homologs play some role in the male flower bud. CCLS96.1 was also expressed in both male and female leaves. CCLS96.1 homologs are expressed in leaves and buds. The CCLS96.1 homologs play some role in the male flower bud. (Sugiyama et al., 2003) CCLS96.1 expressed in both genders in leaves and flowers, yet it is expressed 3-fold higher in male flowers than in female flowers, and 4-8-fold higher in female leaves than in male leaves suggestive that CCLS96.1 plays a role in male flowers and perhaps female leaves, a mode of action has yet to be ascertained. (Rymarquis et al., 2008) 14686583, 18448381 PLNlncRbase
EL0286 CCND1 promoter-derived lncRNAs N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL0289 CDKN2B-AS1 N/A N/A N/A mutation Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. 17459456 LncRNADisease
EL0290 CDR1-AS N/A mouse brain N/A N/A acts as a miR-7 sponge 23446346
EL0290 CDR1-AS sequence and computationally analysis, knockdown N/A N/A N/A CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. 23446348
EL0297 cis-NATPHO1;2 qRT-PCR Phosphate homeostasis up-regulated N/A PHOSPHATE1;2 (PHO1;2), a gene involved in phosphate loading into the xylem in rice, and its associated cis-NATPHO1;2 are both controlled by promoters active in the vascular cylinder of roots and leaves. While the PHO1;2 promoter is unresponsive to the plant phosphate status, the cis-NATPHO1;2 promoter is strongly upregulated under phosphate deficiency. 24096344 PLNlncRbase
EL0299 COLDAIR RT-PCR vernalization down-regulated N/A COLDAIR, an intronic long ncRNA of the FLC. COLDAIR is required for the vernalization-mediated epigenetic repression of FLC. COLDAIR physically associates with a component of PRC2 and targets PRC2 to FLC. Our results show that COLDAIR is required for establishing stable repressive chromatin at FLC through its interaction with PRC2. COLDAIR is required for proper repression of FLC during the course of vernalization. COLDAIR is necessary for the recruitment of CLF to FLC chromatin. (Heo et al., 2011) COLDAIR lncRNAs transcribed from the first intron of FLC are also transiently induced by the cold. The CLF subunit of PHD–PRC2 associates with COLDAIR, leading to the enrichment of this complex on FLC chromatin in the cold. A partial deletion of the COLDAIR promoter or knockdown of COLDAIR expression compromises FLC silencing. Thus, COLDAIR is required for FLC silencing by vernalization. (He et al., 2012) COLDAIR, provided the evidence that the lncRNA plays a crucial role in the regulation of flowering time by recruiting a chromatin remodeling complex to the proper target, FLC, for stable silencing by vernalization. COLDAIR, is transcribed from the first intron of FLC and its expression is increased by cold. COLDAIR physically interacts with PRC2 and is required for the enrichment of PRC2 at FLC chromatin by vernalization. Reduced COLDAIR expression by RNAi compromises the vernalization response. The interaction between COLDAIR and PRC2 increases transiently only during the cold exposure but COLDAIR is necessary for the stable maintenance of silenced FLC after cold. (Kim et al., 2012) COLDAIR play a role in the intragenerational repression of FLC. COLDAIR is an lncRNA that is expressed in the sense direction from the first intron of FLC. COLDAIR is induced during cold exposure and associates with PRC2. Its knockdown leads to a decrease in epigenetic silencing, less H3K27me3, implicating it as a required component in the recruitment of PRC2. (Jones et al., 2014) A sense intronic lncRNA named COLDAIR, participate in different phases of the cold-induced repression and the stable silencing of FLC by PRC2. Cold-induced COOLAIR-like and COLDAIR-like lncRNAs could be involved, respectively, in the initial downregulation of DAM genes and the function of PRC2 complexes. (Ríos et al., 2014) In Arabidopsis the COLDAIR lncRNA-triggered chromatin silencing of a central floral repressor known as FLC, involves H3K27me3, but not cytosine methylation. In response to a prolonged cold exposure, COLDAIR expression is induced from the first intron of FLC, and subsequently, this lncRNA recruits a PRC2-like complex to FLC chromatin to deposit H3K27me3, leading to FLC silencing. (He et al., 2013) A long intronic noncoding RNA, named COLD ASSISTED INTRONIC NONCODING RNA (COLDAIR), was shown to be required for the vernalization-mediated epigenetic repression of FLC. COLDAIR physically associates with CLF, suggesting that COLDAIR establishes stable repressive chromatin at FLC through recruiting PRC2 in H3K27me3 deposition. (Yao et al., 2011) In Arabidopsis, the floral repressor FLOWERING LOCUS C (FLC), a master regulator of flowering, is stably suppressed by prolonged exposure to cold, which promotes the enrichment of tri-methylated histone H3K27me3 at FLC locus. This process is mediated by the interaction of a long intronic noncoding RNA (named COLDAIR) to the FLC locus via recruitment of PRC2. (Pignatta et al., 2012) A long intronic noncoding RNA (COLD ASSISTED INTRONIC NONCODING RNA, COLDAIR) is also required for the stable repression of FLC after cold. COLDAIR is transcribed from the first intron of FLC during vernalization and it targets PRC2 to the FLC chromatin. (Justyna et al., 2012) The COLDAIR sense transcript is produced from within FLC intron 1, and plays a role in FLC silencing via recruitment of Polycomb repressing complex 2 (PRC2) to FLC during vernalization. The establishment of H3K27 trimethylation to silence FLC in vernalization requires COLDAIR. (Shin et al., 2014) long noncoding RNA called COLDAIR shown to be important in regulating vernalization responses in Arabidopsis. (Moghe et al., 2012) In mediating transcriptional regulation, histone modification can also involve ncRNAs such as COLDAIR, a cold-inducible long ncRNA that increases H3K27me3 marks at chromatin of the floral repressor FLC through recruitment of polycomb repressive complex 2. (Zhang et al., 2013) Two noncoding RNAs have now been implicated in vernalization induced recruitment of PHD-PRC2. One of these, termed COLDAIR, is a long (about 1 kb) noncoding sense RNA produced from sequences within the large first intron of FLC. Expression of COLDAIR is cold-induced and several observations suggest that it is functionally important for FLC silencing. In particular, transgenes with deletions that removed part or all of the COLDAIR gene showed fairly normal downregulation during cold treatments but regained activity when plants were returned to warm conditions. (Müller et al., 2011) 21127216, 22658650, 22078062, 24808013, 24917873, 23000433, 25211139, 23132786, 23838953, 21876724 PLNlncRbase
EL0300 COOLAIR N/A N/A N/A interaction N/A 23641115
EL0300 COOLAIR N/A N/A N/A interaction N/A 24799695
EL0300 COOLAIR RT-PCR vernalization up-regulated N/A longnpcRNA,COOLAIR (cold induced long antisense intragenic RNA), is cold induced FLC antisense transcripts, and has an early role in the epigenetic silencing of FLC and to silence FLC transcription transiently. COOLAIR suggested to function in early cold induced silencing of FLC transcription; COOLAIR promoter could silence some reporter genes. Suggests COOLAIR may function through transcriptional interference, although a function for the transcripts has not been tested. (Swiezewski et al., 2009) COOLAIR is expressed at A.thaliana FLOWERING LOCUS C(FLC) in response to winter temperatures. Its contribution to cold-induced silencing of FLC was proposed but its functional and evolutionary significance remain unclear. COOLAIR has been shown to participate in FLC downregulation by the autonomous pathway but its function in the cold-induced silencing of FLC is still unclear. Evolutionary conservation of COOLAIR and its seasonal expression in perennial A.alpina supports a significant role for this asRNA in repression of FLC gene expression during vernalization. The COLDAIR lncRNA transcribed from it were previously shown to be required for stable silencing of FLC in A.thaliana. (Castaings et al., 2014) COOLAIR comprises the Class I and II polyadenylated antisense FLC transcripts, and has been proposed to trigger vernalization-mediated FLC silencing by a co-transcriptional mechanism. A recent study using FLC mutants with insertional T-DNAs that can block the full-length transcription and separate the sense and antisense transcription, has revealed that elimination of COOLAIR transcription does not impair FLC silencing by vernalization. Thus, COOLAIR is not essential for FLC silencing. Of note, it is likely that COOLAIR might participate in vernalization-mediated FLC silencing via a co-transcriptional mechanism involving an overlapping transcription of sense and antisense transcripts. (He et al., 2012) COOLAIR is now used to describe the FLC antisense transcript generally, both in warm-and cold-treated plants. COOLAIR transcription is generally positively correlated with sense transcription in a range of flowering mutants that both upregulate (late-flowering mutants) and downregulate (early-flowering mutants) FLC expression. COOLAIR might modulate FLC expression. When vernalized for longer, COOLAIR expression and FLC mRNA decrease over time and remain stably silenced after return to the warm. The involvement of COOLAIR and COLDAIR in regulating FLC during vernalization. (Ietswaart et al., 2012) COOLAIR, produced at Arabidopsis FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense transcript poly(A) site and terminates either early or extends into the FLC promoter region. We now show that splicing of COOLAIR is functionally important. Since reduced use of the COOLAIR proximal poly(A) site disrupted transcriptional repression of FLC,we reasoned that reduced splicing efficiency of the COOLAIR class Ii intron, necessary to generate the exon containing that poly(A) site, might be an important factor in the increased expression of FLC in prp8. (Marquardt et al., 2014) COOLAIR is an antisense RNA that is transcribed in response to cold treatment. COOLAIR is alternatively polyadenylated at the 3' end, resulting in a proximal poly(A)site or a distal ploy(A) site. to reduce the H3K4me2 level at the FLC locus, leading to a transition from an active chromatin state to a repressive state. The reduction of H3K4me2 might benefit the H3K27me3 modification; thus, COOLAIR acts as an in direct recruiter of PRC2. However,how FLD is activated using the proximal site of COOLAIR remains unknown. (He et al., 2013) Two non coding RNAs(ncRNA) are involved in FLC repression. Early FLC silencing is mediated by COOLAIR (cold induced long antisense intragenic RNA), a cold-induced FLC antisense transcript expressed early during vernalization. (Bergonzi et al., 2012) 20010688, 25030056, 22658650, 22785023, 24725596, 24312106 PLNlncRbase
EL0304 CRG In situ hybridization, Northern blotting, Western blotting, RACE, RT-PCR and quantitative RT-PCR N/A N/A interaction CRG deficiency led to reduced locomotor activity and a defective climbing ability-phenotypes that are often seen in CASK mutant. 23074190
EL0306 Crxos RT-PCR and RNA in situ hybridization retina N/A interaction We overexpressed another nat, crxos, in mouse adult retina using adeno-associated viral vectors and we observed a significant decrease in the expression levels of the corresponding sense gene, crx. 15703187
EL0313 CU1NC165 hub-based and module-based methods stress treatment N/A N/A CU1NC165 is response to salicylic acid stimulus, osmotic stress, salt stress, jasmonic acid stimulus, wounding, water deprivation,oxidative stress.(to see table S5 for details) 25799544 PLNlncRbase
EL0314 CU1NC272 hub-based and module-based methods stress treatment N/A N/A For example, one of the cucumber lincRNAs (CU1NC272) targeted by csa-miRNA396b is presented (Fig. 4). 25799544 PLNlncRbase
EL0315 CU1NC333 hub-based and module-based methods stress treatment N/A N/A CU1NC333 is response to osmotic stress, water, salicylic acid stimulus.(to see table S5 for details) 25799544 PLNlncRbase
EL0316 CU1NC355 hub-based and module-based methods stress treatment N/A N/A CU1NC355 is response to fungus stress, salt stress, oxidative stress, osmotic stress.(to see table S5 for details) 25799544 PLNlncRbase
EL0317 CU2NC636 hub-based and module-based methods stress treatment N/A N/A CU2NC636 is response to salt stress, osmotic stress, jasmonic acid stimulus, oxidative stress, water deprivation, wounding.(to see table S5 for details) 25799544 PLNlncRbase
EL0318 CU3NC1105 hub-based and module-based methods stress treatment N/A N/A CU3NC1105 is response to water deprivation, wounding, water.(to see table S5 for details) 25799544 PLNlncRbase
EL0319 CX3CL1 RT-PCR, Southern blot and fluorescence in situ hybridization analyses activated CD4+ T cells N/A expression Ntt has no open reading frame larger than 270 bp. it is transcribed in a select subset of cd4+ t-cell clones propagated in vitro. 9027504
EL0324 CYP707A1 Northern blot/RT-PCR/Microarray ABA treatment up-regulated N/A Fig. 3E shows a fSAT of an ABA-inducible gene, CYP707A1 (At4g19230) encoding ABA 8'-hydroxylase (Kushiro et al. 2004, Saito et al. 2004) and the novel ABA-inducible antisense TUs. The presence of novel ABA-inducible antisense TU was confirmed by real-time RT-PCR and Northern analyses using strand-specific RNA probes (Figs. 3F, 3G); The RD29A and CYP707A1 lancRNAs that were simultaneously accumulated with sense mRNAs, were accumulated by drought- and ABA treatments(Plant Cell Physiol.2008, 49, 1135–1149.). 18625610 PLNlncRbase
EL0328 Dalir N/A neuroblastoma cells up-regulated expression Dali is transcribed downstream of the Pou3f3 transcription factor gene and its depletion disrupts the differentiation of neuroblastoma cells. Locally, Dali transcript regulates transcription of the Pou3f3 locus. Distally, it preferentially targets active promoters and regulates expression of neural differentiation genes, in part through physical association with the POU3F3 protein. 25415054
EL0329 DANCR knockdown Synovium-derived mesenchymal stem cells (SMSCs) N/A interaction N/A 26514989
EL0329 DANCR microarray, quantitative real-time reverse transcription plus the polymerase chain reaction, overexpression human dental pulp cells down-regulated interaction N/A 26646542
EL0337 DHFR upstream transcripts N/A N/A N/A expression The dhfr minor transcript may function in vivo (in cis) to regulate the transcriptional activity of the major (core) promoter. 12461786
EL0338 DHRS4-AS1 gene duplication N/A N/A N/A AS1DHRS4 not only mediates deacetylation of histone H3 and demethylation of H3K4 in cis for the DHRS4 gene, but also interacts physically in trans with the epigenetic modifiers H3K9- and H3K27-specific histone methyltransferases G9a and EZH2, targeting the promoters of the downstream DHRS4L2 and DHRS4L1 genes to induce local repressive H3K9me2 and H3K27me3 histone modifications. 22891334
EL0339 DIO3OS RT-PCR N/A N/A locus The dio3 gene may lie within the structure of the antisense gene, a complex arrangement often observed in imprinted loci. 14962667
EL0340 Dio3os RT-PCR N/A N/A locus The dio3 gene may lie within the structure of the antisense gene, a complex arrangement often observed in imprinted loci. 14962667
EL0343 DLEU1 N/A N/A N/A expression The nondeleted allele of the car and est70/leu1 genes was expressed in b-cll specimens, including those with monoallelic loss 11264177
EL0347 Dlx1as Biochemical analysis midgestation mouse brain N/A expression Antisense dlx-1 and -6 have their highest expression in the svz. 9415433
EL0347 Dlx1as compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
EL0347 Dlx1as RNA-seq, RNA CaptureSeq, and ChIP-seq adult mouse subventricular zone neural stem cell lineage N/A expression shRNA-mediated knockdown of two such lncRNAs, Six3os and Dlx1as, indicate roles for lncRNAs in the glial-neuronal lineage specification of multipotent adult stem cells. 23583100
EL0347 Dlx1as RT-PCR N/A N/A interaction Mice devoid of Dlx1as RNA are viable and fertile, and display a mild skeletal and neurological phenotype reminiscent of a Dlx1 gain-of function phenotype, suggesting a role for this non-coding antisense RNA in modulating Dlx1 transcript levels and stability. 23415800
EL0349 DLX6-AS1 N/A N/A N/A locus the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity 16705037
EL0351 DMRT2 a light-switching pyrene probe living human cell N/A N/A N/A 20679250
EL0359 dutA Disruption of the dutA gene N/A N/A N/A Duta rna functions without being translated into protein. disruption of the duta gene did not cause phenotypic changes, suggesting that the function of duta is redundant. 8127653
EL0369 EMX2OS N/A endometrium N/A interaction A biological function for emx2os, presumably to regulate emx2. 12573261
EL0370 Emx2os N/A endometrium N/A interaction A biological function for emx2os, presumably to regulate emx2. 12573261
EL0372 enod40 RT-PCR Nodule formation up-regulated N/A The absence of conserved sORFs in Brassicales enod40 sequences (A.thaliana, Thlaspi caerulescens and Brassica napus)could be related to the fact that, in contrast to the majority of angiosperms, these species in natural environment do not form effective symbiotic mycorrhizal associations with fungi. Mycorrhizal symbioses are probable evolutionary predecessors of nitrogen-fixing nodule symbioses, and enod40 seems to be involved in both. 17452360 PLNlncRbase
EL0373 enod40 RT-PCR roots up-regulated N/A The absence of conserved sORFs in Brassicales enod40 sequences (A.thaliana, Thlaspi caerulescensand Brassica napus)could be related to the fact that, in contrast to the majority of angiosperms, these species in natural environment do not form effective symbiotic mycorrhizal associations with fungi. Mycorrhizal symbioses are probable evolutionary predecessors of nitrogen-fixing nodule symbioses, and enod40 seems to be involved in both. 17452360 PLNlncRbase
EL0374 enod40 RT-PCR Nodule formation up-regulated N/A enod40 (BI452209) was isolated from a fungus extraradical mycelium during arbuscular mycorrhizal symbiosis with the plant. 17452360 PLNlncRbase
EL0375 ENOD40 Southern and PCR Analysis Nodule formation up-regulated N/A Cytokinin Induces ENOD Gene Expression in Uninoculated Roots. Earlier research had demonstrated that purified Nod factor induced the expression of ENOD40 in uninoculated vetch roots (see ref. 12). A similar response has been found for Glycine soja and alfalfa; ENOD40 transcripts were detected by RNA transfer blot analysis as early as 6 h after treatment (ref. 34; data not shown). Early nodulin genes are characteristically expressed during nodule morphogenesis. 11038545 PLNlncRbase
EL0376 ENOD40 a yeast three-hybrid screening, Immunolocalization N/A N/A interaction Enod40, a short open reading frame-containing mrna, induces cytoplasmic localization of a nuclear rna binding protein in medicago truncatula. 15037734
EL0377 ENOD40 RT-PCR lateral root development up-regulated N/A ENOD40 transcripts are also detected at very early stages of lateral root development, in the dividing pericycle cells of the root stele that give rise to the lateral root primordia. In sections of nodules at this stage of development, the ENOD40 transcripts are localized in dividing cells of the root pericycle and in the forming connecting vascular bundle.The ENOD40 gene is expressed in the differentiating tissues of emerging lateral roots. Expression during nodule and lateral root development. ENOD40 is proven to be an important gene not only because it is involved in nodule development from very early stages, but also because it could serve as a tool in gaining access to mechanisms involved in the determination of other developmental processes in the plant. Furthermore, due to its differential expression in adventitious and acropetal lateral roots, ENOD40 gene could serve as a molecular marker in studies of lateral root initiation. 8605294 PLNlncRbase
EL0378 ENOD40 RT-PCR Nodule formation down-regulated N/A The expression of ENOD40 in Sesbania rostrata, an annual legume endemic to the Sahel region of West Africa and one of the few legume species that can be nodulated on stems as well as on roots. 9620265 PLNlncRbase
EL0379 enod40 RT-PCR roots up-regulated N/A The absence of conserved sORFs in Brassicales enod40 sequences (A.thaliana, Thlaspi caerulescens and Brassica napus)could be related to the fact that, in contrast to the majority of angiosperms, these species in natural environment do not form effective symbiotic mycorrhizal associations with fungi.Mycorrhizal symbioses are probable evolutionary predecessors of nitrogen-fixing nodule symbioses, and enod40 seems to be involved in both. 17452360 PLNlncRbase
EL0380 ENOD40 RT-PCR roots up-regulated N/A ENOD40, which are activated during early stages of Rhizobium-induced nodulation, are also induced during AM formation. These observations, together with the ancient nature of AM formation, suggest that some of the plant processes leading to nodulation may have evolved from those already established for fungal endosymbiosis. ENOD40, is also not very attractive for Nod factor signal transduction studies since it is activated in the root pericycle and it is unknown whether Nod factors are transported to this tissue. Furthermore, this gene can be activated by chitin fragments. Hence, this gene might be activated by fungal cell wall fragments, which makes it unclear whether its expression is of physiological meaning. 10.1046/j.1365-313x.1998.00228.x PLNlncRbase
EL0381 ENOD40 RT-PCR roots up-regulated N/A ENOD40, an early nodulin gene, is expressed following inoculation with Rhizobium meliloti or by adding R.meliloti-produced nodulation (Nod) factors or the plant hormone cytokinin to uninoculated roots. It is detectable in the root pericycle opposite the nodule primordium even before the appearance of infection threads, and is also found later on, associated with vascular strands in mature nodules. Comparison of the enod40 sequence isolated from several legumes and one non-legume did not reveal any conserved large ORF. Instead, a conserved region was found which may allow the production of a particularly stable cytoplasmic RNA. Therefore it has been proposed that enod40 encodes an RNA with regulatory function. In addition ENOD40 also shows a very short ORF of only 10–13 amino acids, but the 34-untranslated region appears to have important functions as a riboregulator. 9847177 PLNlncRbase
EL0382 ENOD40 RT-PCR stem, lateral root primordia, embryonic tissue up-regulated N/A ENOD40 still able to interact with mycorrhizal fungi. Furthermore, no phenotypic aberrations correlated to the presence of e40-mum1. ENOD40 expression is also observed in the stem, lateral root primordia, and in embryonic tissue, it is likely that ENOD40 is also involved in nonsymbiotic processes. 14522083 PLNlncRbase
EL0383 enod40 Northern blot/Southern blot Nodule formation down-regulated N/A The alb1 is a symbiotic mutant of lotus japonicus that form empty nodules, mature alb1 nodules exhibied very weak or no expression of enod40 in the peripheral cells of the undeveloped nodule vascular bundle. ENOD40 may play a role in the differentiation of nodule vascular bundles. Expression of enod40 in alb1 nodules is restricted to early stages of nodule initiation. Nodule initiation on alb1 root is accompanied by the expression of enod40 in the same spatial pattern as and at a level comparable to, those in the wild type nodules. (Imaizumi-Anraku et al., 2000) Knock-down of ENOD40 leads to severe suppression of nodule primordium initiation but does not affect early bacterial infection events, thus clearly indicating that ENOD40 is required for nodule primordium formation as well as for subsequent nodule rganogenesis. knockdown of two ENOD40s in L.japonicus caused strong inhibition of nodulation. (Kumagai et al., 2006) In situ localization of LjENOD40 genes transcripts in Lotus japonicus(Gifu B-129) root nodules, young seed pods, and embryos. ENOD40, an early nodulin gene, has been postulated to play a significant role in legume root nodule ontogenesis. High levels of ENOD40 gene transcripts were found in nonsymbiotic tissues such as stems, fully developed flowers, green seed pods, and hypocotyls. lower level of transcripts was observed in leaves, roots, and cotyledons. In mature nodules, transcripts of both ENOD40 genes accumulate in the nodule vascular system; in young seed pods strong signal is observed in the ovule, particularly in the phloem and epithelium, as well as in globular stage embryos. ENOD40 genes are indirectly triggered by Nod factors via an effect on the levels of common plant hormones such as auxin. The expression of ENOD40 in developing embryos, as well as in ovule tissues, of L.japonicus adds further proof to the suggestion that the ENOD40 gene is a plant gene involved in organogenesis. (Flemetakis et al., 2000) 11129043, 16816411, 10975655 PLNlncRbase
EL0384 enod40 RT-PCR Nodule formation up-regulated N/A enod40 is not an inducer of cell division per se, but other factors likely present only in the inner cortex are required to complete cell cycle activation. Stable constitutive expression of enod40 in transgenic plants resulted in a large proportion of dividing root cortical cells when grown under nitrogen-limited conditions Translation was observed in epidermal and outer cortical cells of intact roots. As well as accelerated nodulation. Further suggesting that our transient assay is related to the biological activity of enod40 in the root ortex. enod40 action in alfalfa roots. enod40 regulation in nodule organogenesis. (Sousa et al., 2001) Enod40 is a key regulatory gene expressed early during nodule organogenesis. Enod40 is one of the first molecular markers expressed at the onset of nodule organogenesis in the root pericycle and cortex. Enod40 has been proposed as one of the key regulatory genes involved in a signal transduction pathway activated during nodule initiation. (Jiménez-Zurdo et al., 2000) MsENOD40 transcripts can be detected within 24h after Rhizobium meliloti infection and are found not only in the root pericycle cells and nodule primordia as reported for both soybean and pea ENOD40, but also in cells typically classed as meristems: the distal ends of nodules and developing lateral roots, the margins of young leaf primordia, and the procambial cells of the stem and root.In 10-day-old nodules, MsENOD40 transcripts were restricted to the nodule meristem and to cells surrounding the vascular bundle (not shown). In mature (21-day or older) nodules, MsENOD40 transcripts were localized to the cells of the meristem and immediately adjacent to it, with the intensity of label decreasing in the invasion zone and older parts of the nodule. (Asad et al., 1994) Early nodulin genes are characteristically expressed during nodule morphogenesis. MsENOD40 would be expressed in mycorrhizal roots. because transcripts for these genes accumulate in the bacteria-free nodules elicited by R.Meliloti exopolysaccharide (exo) mutants or in alfalfa roots treated with auxin transport inhibitors. MsENOD40 transcripts accumulated in the cells of the pericycle and to a more limited extent in the epidermis and inner cortical cells, especially those containing immature arbuscules. Forming arbuscular mycorrhizae and Rhizobium-induced nodules.we show that mycorrhizae resemble nodules at the molecular level in that these two early nodulin genes are expressed. We also show that cytokinin induces both MsENOD2 and MsENOD40 expression in uninoculated roots,indicating this plant hormone may be part of the mechanism of signal transduction. (van et al., 1997) 11113209, 10656590, 10.1007/BF01276808, 11038545 PLNlncRbase
EL0385 enod40 RT-PCR nodule initiation up-regulated N/A enod40, expressed in spontaneous nodules nodule-related organs developed in the absence of Rhizobium on certain alfalfa plants during nitrogen limitation. This indicates that enod40 expression is associated to the nodule developmental program independently of any infection process. Interestingly, an enod40 homolog was recently found in tobacco whose expression increases auxin tolerance of tobacco protoplasts. enod40 is involved in the initiation of root nodule organogenesis. enod40 expression induced dedifferentiation and division of cortical cells under nitrogen-limiting conditions. Our results suggest that this early nodulin gene is involved in the initiation of nodule development. (Charon et al., 1997) enod40, has a regulatory function in nodule initiation. enod40 is highly conserved among leguminous plants and it has also been identied in the non-legumes tobacco, rice and maize. In the legume roots, it is expressed in the early stages of the interaction, specically in the pericycle adjacent to the protoxylem pole and well before the initiation of cortical cell divisions that lead to nodule formation. Furthermore, it is induced by NFs and chitin pentamers and the phytohormone cytokinin. (Girard et al., 2003) ENOD40 was identified as a candidate for such a plant factor with a regulatory role during nodulation. ENOD40 Bright Yellow-2 (BY-2) tobacco cell suspensions. ENOD40 action can be counteracted by an ethylene perception blocker, indicating that ethylene is a negative regulator of elongation growth in 35S:NtENOD40 cells, and that the NtENOD40-induced response is mediated by alteration of ethylene biosynthesis kinetics. (Ruttink et al., 2006) 11038563, 12930950, 12930950 PLNlncRbase
EL0386 enod40 RT-PCR stems up-regulated N/A Studies on rice enod40 suggest that legume and non-legume enod40 genes may share some common functions in differentiation and/or functions of vascular bundles, where rice enod40 is mostly accumulated. (Girard et al., 2003) Expression of OsENOD40 was detected only in stems. OsENOD40 is expressed only at the early stages of the development of lateral vascular bundles that conjoin the emerging leaf, and its expression is down-regulated after the onset of leaf expansion. OsENOD40 expression is restricted to lateral (large) vascular bundles only. (Kouchi et al., 1999) 12930950, 10363365 PLNlncRbase
EL0387 enod40 RT-PCR Nodule formation up-regulated N/A The over expression of enod40 in M.truncatula plants infected by Sinorhizobium melilotiresulted in fast nodulation of these transgenic plants. Altered levels of enod40 expression considerably affect nodule induction by S.meliloti. During this symbiotic interaction, overexpression of enod40 resulted in accelerated nodulation and enhanced root growth of transgenic plants. Those plants in which silencing of enod40 gene expression was detected exhibited reduced nodulation capacity. (Charon et al., 1999) Mycorrhizal colonization is regulated by enod40, an early nodulin gene known to be involved in the nodule symbiosis of legumes with nitrogen-fixing bacteria. Medicago truncatula plants overexpressing enod40 exhibited stimulated mycorrhizal colonization in comparison with control plants. Overexpression of enod40 promoted fungal growth in the root cortex and increased the frequency of arbuscule formation. enod40 might be a plant regulatory gene involved in the control of the mycorrhizal symbiosis. Overexpression of enod40 Promotes Development of Arbuscules. M.truncatula plants overexpressing enod40 exhibited accelerated mycorrhizal colonization.This paper shows that alteration in the transcript level of the enod40 gene has an effect on the growth of mycorrhizal fungi in the root and on the development of cells containing arbuscules. (Staehelin et al., 2001) ENOD40 expression was detected in cells surrounding the giant cells but not within the giant cells. ENOD40 up-regulation in giant cells and their surrounding cells. overexpressing ENOD40, increased initiation of nodule primordia was observed at early timepoints, which was accompanied by a proliferation response close to the root tip . ENOD40 induction is a limiting step in primordium formation, ENOD40 could play a role in transport of compounds. The early nodulin gene ENOD40 involved in primordium formation and the cell cycle gene CCS52a required for cell differentiation and endoreduplication, are expressed in galls of the host plant. (Favery et al., 2002) Overexpression of enod40 in Medicago truncatula results in a considerable increase of cortical cell divisions when plants are subjected to nitrogen-limiting conditions. Interestingly, such plants infected by Sinorhizobium meliloti nodulate faster and exhibit increased sensitivity to the Nod signals upon treatment with purified Nod factors or inoculation with S.meliloti mutants. In mature nodules, enod40 is expressed in the pericycle of the vascular bundles but also in several non-symbiotic tissues. (Girard et al., 2003) ENOD40 transcripts are required for correct subcellular localization of RNP particles in legume plants.Transgenic Medicago truncatula overexpressing enod40 exhibited accelerated nodulation, whereas plants with reduced amounts of enod40 transcripts formed only a few and modified nodule-like tructures.Mtenod40 was expressed in nodules at a high level, to a lesser extent in stems and roots,and was not detected in leaves. (Campalans et al., 2004) Under nitrogenlimiting conditions overexpression of Medicago truncatula (a model leguminous plant) enod40 (Mtenod40) induces cortical cell division in Medicago roots. These experiments also showed that transient expression of either region 1 carrying box I or a 3'sequence (region 2) spanning box II evoked a response similar to that evoked by the complete gene in alfalfa (Medicago sativa) roots. (Sousa et al., 2011) Transgenic Medicago truncatula plants overexpressing or silenced for ENOD40 exhibited accelerated nodulation or form only a few and modified nodule-like structures, respectively, suggesting that MtENOD40 regulates nodule development. The ENOD40 npcRNA was shown to re-localize a nuclear-speckle RBP from the nucleus to the cytoplasm in Medicago truncatula. Plant RBPs have been also implicated in RNA-mediated chromatin silencing in the FLC locus through interaction with specific antisense transcripts. (Charon et al., 2010) 10521525, 11752473, 12437298, 12930950, 15037734, 11113209, 11113209 PLNlncRbase
EL0388 ENOD40-1 RT-PCR Nodule formation up-regulated N/A GmENOD40 has a complex expression pattern during development of determinate soybean nodules. At early stages of development transcription is induced in dividing root cortical cells, the nodule primordium and the pericycle of the root vascular bundle. In mature soybean nodules, the gene is expressed in the uninfected cells of the central tissue and in the pericycle of the nodule vascular bundles. The GmENOD40 in the nodule vascular bundle requires the presence of intracellular bacteria or infection threads. GmENOD40 was localized in soybean roots at different time points after inoculation with B.japonicum USDA110 to determine where and when the gene is expressed during nodule formation. GmENOD40 gene expression in empty soybean nodule, which formed by B.japonicum mutant 3160. These nodules contain neither intracellular bacteria nor infection thresds. These empty nodules contain at the distal part a central vascular bundle. (Yang et al., 1993) ENOD40 expression was seen in dividing subepidermal cortical cells. ENOD40 expression in response to bacterial inoculation is first detectable in the pericycle of the central vascular system. ENOD40 expression in the pericycle can also be induced by nod signal addition in the absence of bacterial inoculation. ENOD40 express in soybean roots in response to various lipo-chitin signal molecules. (Minami et al., 1996) ENOD40 peptides are involved in the control of sucrose use in nitrogen-fixing nodules. Suggests that ENOD40 peptides may contribute to the control of photosynthate use in plants, which is consistent within situ hybridization studies that revealed that ENOD40 transcripts predominantly occur in the vascular bundles of mature soybean nodules. suggesting a role in the regulation of sucrose utilization in nodules. (Rohrig et al., 2002) The plant gene ENOD40 is one of the earliest nodulin genes specifically induced by nodulation factor-secreting rhizobia and appears to play an important role in root nodule organogenesis. ENOD40 is expressed at an early stage of root nodule organogenesis and has been postulated to play a central regulatory role in the Rhizobium-legume interaction. ENOD40 encoded peptides bind to SuSy suggest that these short translation products are involved in the control of sucrose utilization in nitrogen-fixing nodules. In addition to the two small peptides, the secondary structure of ENOD40 mRNA has been shown to be a key element in the signaling process underlying nodule organogenesis. Modification of sucrose synthase with ENOD40 peptide A activates sucrose cleavage activity whereas the synthesis activity of the enzyme is unaffected. The results are discussed in relation to the role of sucrose synthase in the control of sucrose utilization in nitrogen-fixing nodules. (Röhrig et al., 2004) 8220464, 8758977, 11842184, 15541370 PLNlncRbase
EL0389 enod40-1 RT-PCR Nodule formation up-regulated N/A LjENOD40-1 is highly expressed in the developing vascular bundles. In 21-day-old nodules, LjENOD40-1 gene transcripts accumulate in the vascular tissue surrounding the nodule. Additionally, in green young pods, LjENOD40-1 is up-regulated in the ovules and very strong hybridization signal is observed in the phloem tissue and epithelium cells. High expression was also observed at the globular stage embryo. In mature 21-day-old nodules LjENOD40-1 is highly expressed in vascular tissues of nodule. (Flemetakis et al., 2000) LjENOD40-1 is abundantly induced in very early stages of bacterial infection or Nod factor application, LjENOD40-1 is predominant in responding to Nod factors at the early stages of nodule formation. (Kumagai et al., 2006) 10975655, 16816411 PLNlncRbase
EL0390 enod40-2 RT-PCR Nodule formation up-regulated N/A LjENOD40-2 expression failed to be enhanced in nodule primordia induced by Nod factors, LjENOD40-2 showed a high level of expression in nodule primordia induced by rhizobia and in nodules. The results indicate that LjENOD40-2 is not a pseudogene, and has a role in nodule formation. 15937327 PLNlncRbase
EL0491 FAS-AS1 a culture model of human erythropoiesis erythroblasts derived from CD34(+) hematopoietic stem cell progenitor cells of healthy donors up-regulated N/A Fas-antisense 1 (Fas-AS1 or Saf) was induced during differentiation Fas-antisense 1 (Fas-AS1 or Saf) was induced during differentiation through the activity of essential erythroid transcription factors GATA-1 and KLF1 27067490
EL0491 FAS-AS1 orientation-specific RT-PCR and northern blot analysis Jurkat cells N/A interaction Saf might protect t lymphocytes from fas-mediated apoptosis by blocking the binding of fasl or its agonistic fas antibody. 15829500
EL0501 Firre knockdown mouse embryonic stem cells N/A epigenetics Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus. Knockdown of Firre disrupts perinucleolar targeting and H3K27me3 levels in mouse fibroblasts, demonstrating a role in maintenance of an important epigenetic feature of the inactive X chromosome. 25887447
EL0501 Firre weighted gene coexpression network analysis mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) up-regulated expression Firre, a lncRNA highly enriched in the nucleoplasm and previously reported to mediate chromosomal contacts in ESCs, controls a network of genes related to RNA processing. 26048247
EL0503 FLC N/A N/A N/A interaction The degradation of FRI (FRIGIDA) is accompanied by an increase in the levels of the long noncoding RNA ColdAIR, which reduces the level of histone H3Lys4 trimethylation (H3K4me3) in FLOWERING LOCUS C chromatin to promote flowering. 25538183
EL0513 frq antisense RNAs N/A wild-type strain, mutant strains N/A expression These data provide an unexpected link between antisense rna and circadian timing and provide a new example of a eukaryotic cellular process regulated by naturally occurring antisense rna. 12607002
EL0514 FTX N/A N/A Up-regulated interaction mutation cuasesalteration of transcript levels within the X-inactivation center and particularly important decreases in Xist RNA levels 21118898
EL0517 G730013B05Rik knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0522 GAL10 N/A N/A N/A interaction The GAL lncRNAs could also promote transcriptional activation of the targeted GAL protein-coding genes. Interestingly, these lncRNAs help determine how quickly the GAL genes can be induced in response to galactose, without altering final steady-state transcript levels. 24563719
EL0526 GAS5 knockdown human glioma cells down-regulated interaction The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. Downregulated expression of miR-222 inhibited U87 and U251 cell proliferation and promoted the apoptosis by upregulating bmf. Gas5 combined with the knockdown of miR-222 resulted in the smallest tumor volumes and the longest survivals of nude mice in vivo. 26364613
EL0526 GAS5 N/A N/A Up-regulated expression nonprotein-coding RNA GAS5 in the inhibition of T-cell proliferation 20421347
EL0530 GATA3-AS1 N/A CD4+ T-cell N/A N/A N/A 23870669
EL0532 Gfra1 global expression profiling as responsive to glial cell-derived Spermatogonial stem cells (SSCs) up-regulated N/A an antisense transcript of the GDNF receptor alpha1 26962690
EL0537 Gm15050 lncRNA microarray brown adipose tissue (BAT) and white adipose tissue (WAT) N/A expression We found that AK142386 and AK133540 may affect adipogenesis and metabolism. Our data indicate that AK142386 and AK133540 may be involved in BAT and WAT development through their target genes Hoxa3 and Acad10. 25472036
EL0538 Gm15577 Microarray analysis, RT-qPCR neuronal specific Nbs1-deficient (Nbs1(CNS-del)) mouse model N/A interaction N/A 26705043
EL0540 Gm2694 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0541 Gm30731 knockdown neural stem cell (NSC) in the embryonic and postnatal brain N/A Interaction In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations. 25800779
EL0545 GNG12-AS1 multiple small interfering RNAs (siRNAs) to silence GNG12-AS1 N/A N/A N/A GNG12-AS1 transcripts alters MET signalling and cell migration 26832224
EL0546 GRMZM2G010274_T01 RT-PCR/RNA-seq pollens N/A N/A Two of the lncRNAs (GRMZM2G010274_T01 and GRMZM2G518002_T01) showed additional isoforms in some of the tissues that may reflect tissue-specific splicing variants. 24576388 PLNlncRbase
EL0547 GRMZM2G088590_T04 qRT-PCR/RNA-seq drought up-regulated N/A GRMZM2G088590_T04 which was down-regulated in root stressed for 5 h, was up-regulated in roots stressed for 10h as determined by qRT-PCR. 24892290 PLNlncRbase
EL0548 GRMZM2G420571_T01 qRT-PCR/RNA-seq drought up-regulated N/A GRMZM2G420571_T01 is precursor sequences of MIR172c, GRMZM2G420571_T01 was an intragenic lncRNA, showed up-regulation in drought-stress leaves in comparison with RNA-seq. 24892290 PLNlncRbase
EL0549 GRMZM2G518002_T01 RT-PCR/RNA-seq leaves N/A N/A Two of the lncRNAs (GRMZM2G010274_T01 and GRMZM2G518002_T02) showed additional isoforms in some of the tissues that may reflect tissue-specific splicing variants. 24576388 PLNlncRbase
EL0550 GRMZM2G580571_T01 RT-PCR/RNA-seq roots and shoot apical meristem N/A N/A The B1 locus in maize identified a region located more than 100 kb upstream of the coding required sequence, GRMZM2G580571_T01 in the regulatory region of B1, which was previously identified as for B' paramutation. 24576388 PLNlncRbase
EL0554 GUT15 qRT-PCR/RT-PCR heat and salt down-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G18440 is downregulated by heat and salt stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL0555 H19 deletion of the H19 transcription N/A N/A expression The homozygous mutant animals are viable and fertile and display an overgrowth phenotype of 8% compared with wild-type littermates. 9203585
EL0555 H19 genetic complementation approach H19 KO myoblast cells N/A interaction Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans 22662250
EL0555 H19 knockdown, overexpression N/A N/A interaction H19 modulates let-7 availability by acting as a molecular sponge. H19 depletion causes precocious muscle differentiation, a phenotype recapitulated by let-7 overexpression. 24055342
EL0556 H19 ChIP-seq analysis fetal liver cells N/A interaction Long noncoding RNA H19 inhibits the proliferation of fetal liver cells and the Wnt signaling pathway. 26801864
EL0556 H19 knockdown N/A N/A interaction H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. Methylation changes at numerous gene loci consistent with SAHH modulation by H19. 26687445
EL0556 H19 knockdown gallbladder cancer cell, GBC-SD and NOZ cells up-regulated interaction H19/miR-194-5p/AKT2 axis regulatory network might modulate cell proliferation in GBC. H19 elevation was significantly associated with tumor size. Cell proliferation decreased significantly after knockdown of H19 in GBC-SD and NOZ cells and after knockdown of AKT2 in NOZ cells. the S phase were significantly decreased after knockdown of H19 in NOZ cells but significantly elevated after overexpression of H19 in GBC-SD cells. 26803515
EL0556 H19 lncRNA microarray human bone marrow mesenchymal stem cells (MSCs) up-regulated expression The results showed that the two up-regulated lncRNAs are likely to play important roles in osteogenic differentiation process。 25634249
EL0556 H19 LncRNA microarray Dermal papilla (DP) cells up-regulated expression RP11-766N7.3, H19 and HOTAIR are specific lncRNAs that were aberrantly expressed in DP cells and played an important role in regulating Wnt signaling 25285630
EL0556 H19 N/A undifferentiated multipotent mesenchymal C2C12 cells N/A expression H19 operates as a molecular scaffold that facilitates effective association of KSRP with myogenin and otherlabile transcripts, and we propose that H19 works with KSRP to optimize an AKT-regulated posttranscriptional switch that controls myogenic differentiation. 25385579
EL0556 H19 N/A intestinal epithelial cell up-regulated N/A controlling the intestinal epithelial barrier function by serving as a precursor for microRNA 675 (miR-675 26884465
EL0556 H19 N/A N/A N/A interaction Human h19 rna contains four attachment sites for the oncofetal igf-ii mrna-binding protein (imp) 10875929
EL0556 H19 N/A N/A N/A expression Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. 15645136 LncRNADisease
EL0556 H19 N/A N/A N/A N/A N/A 18587395
EL0556 H19 overexpression, knockdown N/A up-regulated interaction The novel pathway H19/miR-675/TGF-β1/Smad2/HDAC regulates osteogenic differentiation of hMSCs and may serve as a potential target for enhancing bone formation in vivo. 26417995
EL0556 H19 RIP assays combined with luciferase reporter assays osteogenesis in hMSCs up-regulated N/A lncRNA H19 modulates Wnt/β-catenin pathway 26853553
EL0556 H19 RNA interference human K562 leukemia cells N/A interaction Imp-3 protein associates with igf-ii leader-3 and leader-4 mrnas and h19 rna 15753088
EL0556 H19 transfect two embryonal tumour cell lines, RD and G401 N/A expression Two embryonal tumour cell lines, rd and g401, showed growth retardation and morphological changes when transfected with an h19 expression construct. 7692308
EL0560 Halr1 knockdown mouse embryonic stem cells N/A interaction Depletion of linc-HOXA1 RNA at its site of transcription increased transcription of the Hoxa1 gene cis to the chromosome and that exposure of cells to retinoic acid can disrupt this interaction. 23723417
EL0560 Halr1 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0563 HBB N/A N/A N/A expression The human beta-globin locus is divided into three differentially activated chromatin subdomains. large transcripts precisely delineate the active domains at key cell cycle points associated with chromatin transitions and remodeling. 10882078
EL0563 HBB N/A N/A N/A interaction Intergenic transcripts of the beta-globin gene cluster are specifically upregulated in dicer-deficient cells. 16227618
EL0563 HBB nuclear run-on analysis, in situ hybridization analysis erythroid cell lines, nonerythroid cell lines, erythroid tissue N/A expression The plasmid colocalizes with the endogenous beta-globin locus providing insight into the mechanism of transinduction. 9334315
EL0566 HELLPAR N/A N/A N/A mutation We identified a novel long intergenic noncoding RNA (lincRNA) transcript of 205,012 bases with (peri)nuclear expression in the extravillous trophoblast using strand-specific RT-PCR complemented with RACE and FISH. 23093777 LncRNADisease
EL0568 HID1 qRT-PCR seedling photomorphogenesis down-regulated N/A HID1(HIDDEN TREASURE 1), that modulates red-light-mediated seedling photomorphogenesis in Arabidopsis. Knocking down HID1 led to increased levels of PIF3 mRNA, which in turn correlated directly with the elongated hypocotyl phenotype observed in the hid1 mutant seedlings grown under cR. We further demonstrated that HID1 is a chromatin-bound RNA and functions as a direct repressor of PIF3 transcription in cR. Thus, to our knowledge, HID1 appears to be the first lncRNA identified as being involved in the precise control of light-mediated seedling development. HID1 was expressed ubiquitously throughout the Arabidopsis development processes. 24982146 PLNlncRbase
EL0569 HIF1A-AS1 Real‑time polymerase chain reaction (PCR), western blot analysis, lncRNA PCR arrays and chromatin immunoprecipitation human bone marrow stromal cells down-regulated interaction HIF1α‑AS1 is an essential mediator of osteoblast differentiation. 26460121
EL0574 Hm629797 ChOP (Chromatin oligo affinity precipitation) mouse spermatogonial Gc1-Spg cells up-regulated expression Our findings in the Gc1-Spg cell line also correlate with the results from analysis of mouse testicular tissue which further highlights the in vivo physiological significance of mrhl RNA in the context of gene regulation during mammalian spermatogenesis. 25584904
EL0574 Hm629797 N/A N/A N/A locus This meiotically active locus happens to be flanked by a transcribed region encoding a non-protein-coding rna polymerase ii transcript and the previously characterized repair site. 15169920
EL0576 Hog qRT-PCR, ChIP on chip cecal buds N/A interaction N/A 24075990
EL0578 HOTAIR Illumina microarrays and confirmed by RT-PCR Abdominal and gluteal adipose tissue aspirates obtained from 35 subjects N/A interaction Ectopic expression of HOTAIR in abdominal preadipocytes produced an increase in differentiation as reflected by a higher percentage of differentiated cells, and increased expression of key adipogenic genes including PPARγ and LPL 24862299
EL0578 HOTAIR knockdown urothelial bladder cancer (UBC), urine (Ues) up-regulated interaction Knockdown of HOTAIR in UBC cell lines reduces in vitro migration and invasion. 26800519
EL0578 HOTAIR knock-down human cardiomyocytes N/A expression up-regulation of HOTAIR could suppress the expression of CaV1.2 in human cardiomyocytes. However, HOTAIR knock-down promoted CaV1.2 expression in human cardiomyocytes. enforced expression of CaV1.2 increased the calcium level in cardiomyocytes overexpressing HOTAIR. These results for the first time demonstrate that HOTAIR inhibited the intracellular Ca2+ via regulation of CaV1.2 in human cardiomyocytes. 26255135
EL0578 HOTAIR knockdown, Luciferase assays 80 clinical colon cancer tissues up-regulated interaction N/A 26962687
EL0578 HOTAIR LncRNA microarray Dermal papilla (DP) cells up-regulated expression RP11-766N7.3, H19 and HOTAIR are specific lncRNAs that were aberrantly expressed in DP cells and played an important role in regulating Wnt signaling 25285630
EL0578 HOTAIR N/A breast cancer cells N/A interaction Silencing of HBXIP, Hotair, or LSD1 was sufficient to block c-Myc-enhanced cancer cell growth in vitro and in vivo. Taken together, our results support a model in which the HBXIP/Hotair/LSD1 complex serves as a critical effector of c-Myc in activating transcription of its target genes, illuminating long-standing questions on how c-Myc drives carcinogenesis. 26719542
EL0578 HOTAIR N/A N/A N/A N/A serve as scaffolds by providing binding surface 20616235
EL0578 HOTAIR RT-PCR,Conventional ChIP and ChIP-chip ,In situ hybridization,RNA interference N/A N/A N/A We identified a 2.2 kilobase ncRNA residing in the HOXC locus, termed HOTAIR, which represses transcription in trans across 40 kilobases of the HOXD locus. HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus. Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; 17604720
EL0579 Hotair N/A N/A N/A N/A regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793
EL0580 HOTAIRM1 sucrose gradient analysis N/A up-regulated expression Knockdown of HOTAIRM1 quantitatively blunted RA-induced expression of HOXA1 and HOXA4 during the myeloid differentiation of NB4 cells, and selectively attenuated induction of transcripts for the myeloid differentiation genes CD11b and CD18, but did not noticeably impact the more distal HOXA genes. 19144990
EL0581 Hotairm1 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Found to interact with a number of of chromatin binding proteins/complexes in mouse embryonic stem cells including PRC1, PRC2 and CBX1. 21874018
EL0582 HOTTIP Strand-specific RT-PCR, RNA-FISH, RNA Interference, overexpression, RNA Immunoprecipitation, RNA chromatography Primary human fibroblasts N/A N/A driving histone H3 lysine 4 trimethylation and gene transcription 21423168
EL0584 HOXA11-AS N/A N/A N/A interaction Hoxa11 antisense functions by transcriptional interference, repressing hoxa11 expression by competing for transcription of the common gene, rather than by sense/antisense interaction. 12050232
EL0584 HOXA11-AS serial section and whole-mount in situ hybridizations N/A N/A expression In the developing limbs, the sense and antisense transcripts showed complementary expression patterns 7789268
EL0585 Hoxa11os N/A N/A N/A interaction attempts to block hoxa11 function by transfection of the murine uterus with hoxa11 antisense oligonucleotides failed to interrupt normal uterine function, suggesting that hoxa11 antisense does not regulate hoxa11 mrna by formulation of sense/antisense duplexes. 12050232
EL0587 HOXA-AS PCR heart, lung, liver, kidney, colon, placenta, muscle, and brain N/A expression This noncoding transcription is regulated by the retinoic acid morphogen and follows the colinear activation pattern of the cluster. Opening of the cluster at sites of activation of intergenic transcripts is accompanied by changes in histone modifications and a loss of interaction with Polycomb group (PcG) repressive complexes. 17185360
EL0590 HOXA-AS3 RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
EL0591 Hoxd3as RNA blot analysis, in situ hybridization hind brain, liver N/A expression The earliest antisense expression was detected at 10.5 days p.c. in cdna libraries. at 12.5 days p.c., sense and antisense transcripts colocalized in the liver. 7710686
EL0593 Hsromega Fluorescence RNA, In situ immunocytochemical staining N/A N/A interaction The hsromega-n transcripts play essential structural and functional roles in organizing and establishing the hnrnp-containing omega speckles and thus regulate the trafficking and availability of hnrnps and other related rna binding proteins in the cell nucleus. 10984439
EL0593 Hsromega in situ hybridization nonstressed cells N/A expression Transcripts appear abruptly at the time that the zygotic genome becomes transcriptionally active, shortly before the formation of the cellular blastoderm. 1704862
EL0593 Hsromega RNA in situ hybridization somatic cyst cells N/A interaction These results further support a significant role of the noncoding hsromega-n transcripts in basic cellular activities, namely regulation of the availability of hnrnps in active (chromatin bound) and inactive (in omega speckles) compartments. 11910129
EL0594 HSUR1 Microarray and Northern analyses N/A N/A interaction An unexpected role for the hsurs in regulating a remarkably defined and physiologically relevant set of host targets involved in the activation of virally transformed t cells during latency. 15916956
EL0594 HSUR1 N/A T cells N/A Interaction HSURs 1 and 2 interact with the predicted miRNAs in virally transformed T cells. 20558719
EL0595 HSUR2 Microarray and Northern analyses N/A N/A interaction An unexpected role for the hsurs in regulating a remarkably defined and physiologically relevant set of host targets involved in the activation of virally transformed t cells during latency. 15916956
EL0595 HSUR2 N/A T cells N/A Interaction HSURs 1 and 2 interact with the predicted miRNAs in virally transformed T cells. 20558719
EL0598 Huc1 N/A mesodermal tissues N/A expression Mouse huc1 and huc2 act as potent enhancers capable of driving expression of an h19 reporter gene in a range of mesodermal tissues. 11874916
EL0599 Huc2 N/A mesodermal tissues N/A expression Mouse huc1 and huc2 act as potent enhancers capable of driving expression of an h19 reporter gene in a range of mesodermal tissues. 11874916
EL0602 HvCesA6 Strand-specific RT-PCR Cell-wall synthesis down-regulated N/A The increases in abundance of the CesA6 antisense transcript and the 21-nt and 24-nt siRNAs derived from the transcript are coincident with the down-regulation of primary wall CesAs, several Csl genes, and GT8 glycosyl transferase genes, and are correlated with the reduction in rates of cellulose and (1→3),(1→4)-β-D-glucan synthesis. The expression of individual members of the CesA/Csl superfamily and glycosyl transferases share common regulatory control points, and siRNAs from natural cis-antisense pairs derived from the CesA/Csl superfamily could function in this global regulation of cell-wall synthesis. 19075248 PLNlncRbase
EL0603 HvISP1 qRT-PCR phosphate balance up-regulated N/A HvIPS1 plays a distinct role in the regulation of the low-affinity Pi transporters. The expression of HvIPS1 is highly correlated with the expression of HvPHT1;3 and HvPHT1;6 in the four barley genotypes tested under low-P conditions (Figs. 4 and 6), suggesting that HvIPS1 plays a unique role in Pi remobilization. (Huang et al., 2011) The expression patterns of other members of the TPSI1/Mt4 family in monocots were also investigated. The induced expressions of OsIPS1, HvIPS1, ZmIPS2 and TalIPS2 were stronger than those of OsIPS2, HvIPS2 ZmIPS1 and TalIPS1 in roots after 4 or 10 d of Pi starvation, whereas higher induced expressions of OsIPS2, HvIPS1, ZmIPS1 and TalIPS1 were detected in shoots. (HOU et al., 2005) 21606317 PLNlncRbase
EL0608 IGF2-AS RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
EL0609 IL7R human lncRNA microarray assays N/A down-regulated N/A lnc-IL7R was capable of diminishing the LPS-induced inflammatory response 24723426
EL0610 ILF3 overexpression human fibroblast cells down-regulated interaction Overexpression of SALNR delayed cellular senescence in fibroblast cells. Ras-induced stress promotes NF90 nucleolus translocation and suppresses its ability to suppress senescence-associated miRNA biogenesis, which could be rescued by SALNR overexpression. 26487301
EL0612 IPO5P1 microarray, RT-qPCR human monocyte-derived macrophages (MDMs) incubated in conditions causing activation toward M(IFN-γ + LPS) or M(IL-4) phenotypes. up-regulated expression Knockdown of TCONS_00019715 following the activation of THP-1 cellls using IFN-γ and LPS diminished the expression of M(IFN-γ + LPS) markers, and elevated the expression of M(IL-4) markers. 26796525
EL0613 IPS1 Northern blot/qRT-PCR phosphate balance up-regulated N/A Arabidopsis thaliana(AtIPS1) that is induced by Pi starvation, and studied the effect of cytokinin on its expression in response to Pi deprivation. AtIPS1 belongs to the TPSI1/Mt4 family, the members of which are induced by Pi starvation, and the RNAs of which contain only short, non-conserved open reading frames. AtIPS1 is induced by Pi starvation and expression in the root. The induction of AtIPS1 expression under Pi starvation is reversible. AtIPS1:GUS responsiveness to Pi starvationin roots is repressed by cytokinins. However, cytokinins did not repress the increase in root-hair number and length induced by Pi starvation, a response dependent on local Pi concentration rather than on whole-plant Pi status. Our results raise the possibility that cytokinins may be involved in the negative modulation of long-distance, systemically controlled Pi starvation responses, which are dependent on whole-plant Pi status. (Ana et al., 2002) The lncRNA, INDUCED BY PHOSPHATE STARVATIONA (IPS1), is a noncoding transcript that is intimately associated with the function of miRNA399. Under phosphate starvation, the expression PHO2, a target of miRNA399, is up-regulated due to increased binding and sequestering of miRNA399 by IPS1. IPS1 contains complementary sequences to the phosphate (Pi) starvation-induced miRNA399 and thus can compete with PHO2 transcripts for the binding of miRNA399. However, IPS1 is not cleaved by the miRNA because the paring with miRNA is interrupted by a mismatched loop at the expected miRNA cleavage site. (Kim et al., 2011) The effect of miR-399 on PHO2 mRNA was greatly suppressed by simultaneous IPS1 overexpression,suggesting that IPS1 antagonizes the effects of miR-399. In agreement with previous reports on the negative effect of PHO2 on shoot Pi content9-12, the shoot Pi content of IPS1-overexpressing plants was lower than that in their counterparts lacking IPS1 overexpression. And IPS1 contains a motif with sequence complementarity to the phosphate (Pi) starvation-induced miRNA miR-399,IPS1 over expression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. (Franco-Zorrilla et al., 2007) Induced by Phosphate Starvation1(IPS1), which can bind to ath-miR399 with a three-nucleotide bulge between the 5'end 10th and 11th positions of ath-miR399. Such pairing abolished the cleavage effect of ath-miR399 on IPS1; thus, IPS1 can serve as a decoy for ath-miR399 to interfere with the binding of ath-miR399 to its other targets. (Wu et al., 2013) Under phosphate starvation, transcript levels of the natural target of miR399, PHO2, are increased because of the binding and sequestering of miR399 by IPS1. IPS1 contains a centrally bulged miR399-binding site (called 'target mimic’) that prevents IPS1 cleavage by miR399 and apparently inhibits recycling of the miR399 effector complex. (Brosnan et al., 2009) Induced by Phosphate Starvation 1 (IPS1) with a binding site for miR-399, a phosphate starvation-induced miRNA. However,miR-399 binding does not induce degradation of the IPS1 transcript due to mismatched nucleotides in the binding site, but rather results in sequestration of miR-399 from other target transcripts. Thus, IPS1 can effectively function as a sponge in hibiting the number of miR-399 molecules available for regulating its target PHO2 mRNA. The Arabidopsis thaliana pho2 mutant is aphosphate over-accumulator. This mutant carries a mutation in the PHO2 gene,encoding a ubiquitin-conjugating enzyme(UBC24), that leads to a reduction in full-length transcripts. In response to phosphate starvation, IPS1 RNAs are induced. The latter can sequester miR-399 resulting in stabilization and increased accumulation of PHO2 and, concomitantly, in reduced shoot phosphate content. (Kartha et al., 2014) 22104407, 17643101, 23429259, 19447594, 24523727 PLNlncRbase
EL0614 IPS1 Northern blot/RT-PCR phosphate balance up-regulated N/A IPS1 has complementarity to miR-399, but contains a mismatch loop that renders it uncleavable when miR-399 binds. Since target cleavage is the usual plant miRNA pathway the non-cleavable nature of IPS1 acts to sequester the miRNA; Competing endogenous RNA (ceRNA). IPS1 carries out target mimicry to sequester miR-399 and attenuate its effects allowing increased expression of miR-399 targets including PHO2. 17643101 PLNlncRbase
EL0615 IPS1 Northern blot/qRT-PCR phosphate balance up-regulated N/A The effect of miR-399 on PHO2: GFP was suppressed by simultaneous expression of IPS1, and a mutant form of IPS1 with reduced complementarity to miR-399 did not affect miR-399-mediated silencing of PHO2: GFP. Finally, we reconstituted the interaction between IPS1, miR-399 and PHO2 in a system in which complementary and compensatory mutations were introduced in all three components. 17643101 PLNlncRbase
EL0616 IPS1 Northern blot/qRT-PCR phosphate balance up-regulated N/A IPS1 RNA is not cleaved but instead sequesters miR-399. Thus, IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content5–8. Engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399. 17643101 PLNlncRbase
EL0617 IPS1 Northern blot/qRT-PCR phosphate balance up-regulated N/A IPS1 RNA is not cleaved but instead sequesters miR-399. Thus, IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content5–8. Engineering of IPS1 to be cleavable abolishes its inhibitory activity on miR-399. 17643101 PLNlncRbase
EL0621 JPX knockdown, FISH, Quantitative RT-PCR, Allele-specific RT-PCR, Luciferase assay ES cell lines N/A interaction Jpx as an Xist activator 21029862
EL0625 KCNIP4-IT1 N/A cerebellum N/A expression Like noncoding rnas, the porcine and human sequences have no common conserved open reading frame and share stretches of high homology interrupted by stretches with almost no homology. 12515386
EL0626 KCNIP4-IT1 N/A cerebellum N/A expression Like noncoding rnas, the porcine and human sequences have no common conserved open reading frame and share stretches of high homology interrupted by stretches with almost no homology. 12515386
EL0627 KCNQ1DN N/A N/A N/A epigenetics Continuously hypermethylated upon aging. 22067257 LncRNADisease
EL0628 KCNQ1OT1 CHIP, PCR, knockdown, RNA-guided chromatin conformation capture method N/A N/A interaction The 5' region of Kcnq1ot1 RNA orchestrates a long-range intrachromosomal loop between KvDMR1 and the Kcnq1 promoter that is required for maintenance of imprinting.PRC2 (polycomb repressive complex 2), which participates in the allelic repression of Kcnq1, is also recruited by Kcnq1ot1 RNA via EZH2. 24395636
EL0628 KCNQ1OT1 ChIP,PCR,FISH,immuno-FISH human placenta N/A interaction The bidirectional silencing property of Kcnq1ot1 maps to a highly conserved repeat motif within the silencing domain, which directs transcriptional silencing by interaction with chromatin, resulting in histone H3 lysine 9 trimethylation. 18299392
EL0628 KCNQ1OT1 Chromatin RNA Immunoprecipitation and RNA Immunoprecipitation,ImmunoDNA FISH,Chromatin Oligo-Affinity Precipitation placenta and liver N/A interaction our data describe a mechanism whereby Kcnq1ot1 establishes lineage-specific transcriptional silencing patterns through recruitment of chromatin remodeling complexes and maintenance of these patterns through subsequent cell divisions occurs via targeting the associated regions to the perinucleolar compartment. 18951091
EL0629 Kcnq1ot1 N/A a knockout mouse with a deletion encompassing an 890-bp silencing domain (Delta890) downstream of the Kcnq1ot1 promoter N/A N/A Kcnq1ot1 RNA might mediate the silencing of ubiquitously imprinted genes by maintaining allele-specific methylation through its interactions with Dnmt1 20573698
EL0629 Kcnq1ot1 N/A N/A N/A N/A silence mulitple genes 21345374
EL0629 Kcnq1ot1 N/A an embryonic stem (ES) cell N/A N/A t Kcnq1ot1 silencing extends nearly 300 kb further than previously reported and led us to examine other transcripts between IC1 and IC2 21576366
EL0629 Kcnq1ot1 RNA/DNA FISH mouse embryo and placenta N/A epigenetics The paternally expressed long noncoding RNA (ncRNA) Kcnq1ot1 regulates epigenetic gene silencing in an imprinted gene cluster in cis over a distance of 400 kb in the mouse embryo, whereas the silenced region extends over 780 kb in the placenta. Gene silencing by the Kcnq1ot1 RNA involves repressive histone modifications, including H3K9me2 and H3K27me3, which are partly brought about by the G9a and Ezh2 histone methyltransferases. 19144718
EL0630 Khps1 N/A N/A N/A interaction Khps1 activates SPHK1 expression by recruiting the histone acetyltransferase p300/CBP to the SPHK1 promoter, which leads to local changes of the chromatin structure that ensures E2F1 binding and enhances transcription. 26590717
EL0631 Khps1a N/A N/A N/A expression Overexpression of two fragments of khps1 caused demethylation of cg sites in the t-dmr. furthermore, this rna-directed demethylation was associated with dna methylation at three cc(a/t)gg sites in the t-dmr. 15325271
EL0632 KIR antisense lncRNA N/A Human NK cells N/A interaction Overexpression of MZF-1 in developing NK cells led to decreased KIR expression, consistent with a role for the KIR antisense lncRNA in silencing KIR gene expression early in development. 23863987
EL0636 Ks-1 RT-PCR, cDNA cloning, fluorescent in situ hybridization honeybee brain N/A N/A Ks-1 encodes a novel class of noncoding nuclear rna and is possibly involved in the regulation of neural functions. 12088150
EL0641 LDMAR RT-PCR normal pollen development up-regulated N/A Long-day-specific male-fertility-associated RNA (LDMAR), regulates PSMS in rice. We found that sufficient amount of the LDMAR transcript is required for normal pollen development of plants grown under long-day conditions. LDMAR is required for male fertility under long day conditions. The spontaneous G→C mutation causing a SNP between 58N and 58S altered the RNA secondary structure of this region. This alteration eventually brought about heritable increased methylation in the promoter region of LDMAR, thus reducing the level of transcription specifically under long-day conditions. Such a reduced level of LDMAR results in premature PCD in anther development under long days, thus causing male sterility. (Ding et al., 2012) Photoperiod-sensitive male sterility (PSMS) is a valuable germplasm for hybrid rice breeding. Recently, we cloned pms3, a locus controlling PSMS, which encodes a long non-coding RNA called LDMAR required for normal male fertility of the rice plant under long-day conditions.Increased methylation in the promoter of LDMAR in the PSMS rice (Nongken 58S) relative to the wild-type (Nongken 58) reduced expression of LDMAR leading to male sterility under long-day conditions.all in all, reduced the expression of this lncRNA, resulting in male sterility under long-day conditions. LDMAR required for normal male fertility of the rice plant under long-day conditions. Reduction of LDMAR in Nongken 58S changed the critical day length for fertility recovery and delayed the fertility recovery under short-day conditions. This result added to our understanding of the molecular mechanism for PSMS. (Ding et al., 2012) A long non-coding RNA (lncRNA) named LDMAR. A sufficient amount of LDMAR is required for male fertility under long-day conditions. A spontaneous G-C mutation causing a SNP between NK58 and NK58S, eventually brings about heritable increased methylation in the promoter region of LDMAR, which reduces the level of LDMAR expression. This then results in premature programmed cell death (PCD) in anther development under long days, and hence male sterility. In addition, RNA-dependent DNA methylation (RdDM) is involved in the regulation of PGMS. Promoter siRNA of LDMAR derived from AK11270 is associated with the DNA methylation level of LDMAR, which reduces the expression level of LDMAR, and therefore male sterility in Nonken 58S under long-day conditions. (Wang et al., 2013) 22308482, 23024213, 23596452 PLNlncRbase
EL0643 LeENOD40 RT-PCR vascular tissue up-regulated N/A LeENOD40 is expressed in vascular tissue, expression of LeENOD40 in tomato is found in flowers and germinated seeds. Furthermore, it is active in vascular tissues of stems, young leaves (data not shown) and roots. In an early stage of lateral root development the lateral root primordium is flanked by regions of the vascular bundle where LeENOD40::GUS is expressed, whereas in the region where the primordium is located ENOD40 expression is low. LeENOD40::GUS is also expressed in a specific manner during flower development. LeENOD40 expression marks the time of pollination of the stigma. LeENOD40 expression also occurs in the petals after pollination. And based on our observations, we suggest that LeENOD40 could have a role in reducing ethylene production or in reducing local effects of ethylene production. 14508686 PLNlncRbase
EL0651 LINC00261 RNA-seq, knockdown human endoderm and pancreatic cells N/A Interaction DEANR1 contributes to endoderm differentiation by positively regulating expression of the endoderm factor FOXA2. Mechanistically, DEANR1 facilitates FOXA2 activation by facilitating SMAD2/3 recruitment to the FOXA2 promoter. 25843708
EL0656 LINC00461 In Situ Hybridization, RT-PCR, knockdown Visc-2 knockout mice N/A expression Despite a neurodevelopmental expression pattern of Visc-2 that is highly localized to the cortex and sites of neurogenesis, anomalies in neither cytoarchitecture nor neuroproliferation were identified in knockout mice. These results are important because they contribute to a growing body of evidence that lncRNA loci contribute on average far less to brain and biological functions than protein-coding loci. 25209608
EL0665 LINC00663 RT-PCR and qPCR methods various cancer cell lines N/A expression LINC00663 was shown to be differentially expressed in various human tissues and cancer cell lines. LINC00663 undergoes alternative splicing and the novel exonic region alters its secondary structure and its interactions with potential targeting miRNAs. 26743782
EL0705 LINC01613 RT-PCR lungs of IPF (idiopathic pulmonary fibrosis) patients down-regulated expression while knock-down of the lncRNA n341773 increased collagen expression in lung fibroblasts. 26269497
EL0711 LINC02 qRT-PCR lint-fuzz/linted-fuzzless up-regulated N/A Specifically, the expression of one lncRNA (LINC02) was highlighted, the expression of which might in part underlie the development of lint and fuzz fibres. This lncRNA produced significantly higher transcription levels in lint-fuzz/linted-fuzzless cottons than in lintless-fuzzless cottons (P < 0.05). 25919642 PLNlncRbase
EL0712 linc1242 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0713 linc1257 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Found to interact with a number of chromatin binding proteins/complexes in mESCs including PRC1, PRC2, JARID1B, SUV39H1, SETD8 and CBX1, with the general pattern being interaction with repressors of gene expression. 21874018
EL0714 linc1368 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL0722 Linc-rbe N/A cultured primary hippocampal neurons from adult rat up-regulated expression AtRA-mediated transcriptional upregulation of endogenous expression of a novel long intergenic noncoding RNA-rat brain expressed (LINC-RBE) in cultured primary hippocampal neurons from adult rat. 26572536
EL0722 Linc-rbe RT-PCR and RNA in situ hybridization rat brain N/A expression The expression pattern of the LINC-RBE showed distinct association with the specific neuro-anatomical regions, cell types and sub-cellular compartments of the rat brain in an age-related manner. Thus, its expression increased from immature stage to adulthood and declined further in old age. 26363523
EL0723 LincR-Ccr2-5'AS N/A T cell samples N/A N/A LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the TH2 subset of helper T cells and was important for the migration of TH2 cells. 24056746
EL0724 lincRNA1039 RT-qPCR drought and cold up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. Drought-induced lincRNA1039 is also up-regulated by cold stress. 24948679 PLNlncRbase
EL0725 lincRNA1085 RT-qPCR drought down-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. 24948679 PLNlncRbase
EL0726 lincRNA1128 RT-qPCR drought and cold N/A N/A lincRNA1128 regulated ptc-miR482a.1 as target mimics and inhibit its function. Ptc-miR482a.1 has been investigated previously and regulates specific disease-resistance proteins in P.trichocarpa. This miRNA is known to be responsive to four abiotic stresses (cold, heat, salt, and dehydration) in Populus. 24948679 PLNlncRbase
EL0727 lincRNA1310 RT-qPCR stress treatments N/A N/A LincRNA1310 is a target of ptc-miR476a. 24948679 PLNlncRbase
EL0728 lincRNA1534 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. 24948679 PLNlncRbase
EL0729 lincRNA1828 RT-qPCR drought and cold N/A N/A lincRNA1828 regulated ptc-miR482a.1 as target mimics and inhibit its function. Ptc-miR482a.1 has been investigated previously and regulates specific disease-resistance proteins in P.trichocarpa. This miRNA is known to be responsive to four abiotic stresses (cold, heat, salt, and dehydration) in Populus. 24948679 PLNlncRbase
EL0730 lincRNA20 RT-qPCR drought and cold up-regulated N/A Drought-responsive lincRNA20 adsorbed ptc-miR476, which is a specific family in Populus. lincRNA20 is also specific to Populus, and may thus represent a Populus-specific regulatory mechanism. 24948679 PLNlncRbase
EL0731 lincRNA2085 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. 24948679 PLNlncRbase
EL0732 lincRNA2131 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. 24948679 PLNlncRbase
EL0733 lincRNA2198 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. 24948679 PLNlncRbase
EL0734 lincRNA262 RT-qPCR stress treatments N/A N/A LincRNA262 is the target and target mimic of ptc-miR156c. 24948679 PLNlncRbase
EL0735 lincRNA2623 RT-qPCR stress treatments N/A N/A lincRNA2623 regulated ptc-miR482a.1 as target mimics and inhibit its function. Ptc-miR482a.1 has been investigated previously and regulates specific disease-resistance proteins in P.trichocarpa. This miRNA is known to be responsive to four abiotic stresses (cold, heat, salt, and dehydration) in Populus. 24948679 PLNlncRbase
EL0736 lincRNA2752 RT-qPCR drought up-regulated N/A Drought-responsive lincRNA2752 is a target mimic of ptc-miR169, and could reduce the expression of ptc-miR169. MiR169 is known to regulate the NF-YA transcription factor in plants, which is important in drought stress regulation. This network may be involved in the lincRNA2752-regulation of drought tolerance through miR169 and NF-YA. However, the specific regulatory mechanism requires further investigation, and knock out and over-expression of the lincRNA genes in P.trichocarpa should be performed to increase our understanding of the regulatory mechanisms. 24948679 PLNlncRbase
EL0737 lincRNA2962 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. Drought-induced lincRNA2962 is also down-regulated by cold stress. 24948679 PLNlncRbase
EL0738 lincRNA3241 RT-qPCR drought up-regulated N/A A total of 504 lincRNAs were identified (see Supplementary Table S9 at JXB online), and eight were subjected to experimental validation by quantitative real-time polymerase chain reaction (RT-qPCR). As shown in Fig. 6, the expression patterns indicated by the sequencing and RT-qPCR results of drought-responsive lincRNAs were consistent, in a conclusion, those lncRNAs response to drought stress. LincRNA3241 is down-regulated by water and cold stress. 24948679 PLNlncRbase
EL0747 LINC-ROR knockdown wild-type and NRF2 knockdown mammary stem cells N/A expression NRF2 knockdown or ROR overexpression leads to increased stem cell self-renewal in mammary stem cells 25231996
EL0748 LINC-RSAS RT-PCR, in situ RNA hybridization rat brain N/A expression N/A 26750132
EL0751 LL34 N/A lung and foregut endoderm N/A interaction Two lncRNAs, LL18/NANCI (Nkx2.1-associated noncoding intergenic RNA) and LL34, play distinct roles in endoderm development by controlling expression of critical developmental transcription factors and pathways, including retinoic acid signaling 24939938
EL0754 lnc-168 qRT-PCR heat and salt down-regulated N/A lnc-508 was down-regulated by heat and cold, while lnc-168 was down-regulated by heat and salt in Arabidopsis. 10.3389/fpls.2015.00267 PLNlncRbase
EL0755 lnc-173 qRT-PCR/RT-PCR high light up-regulated N/A lnc-173 and lnc-225,which are potentially regulated by high light and PIF transcription factors. 25256571 PLNlncRbase
EL0756 lnc-225 qRT-PCR/RT-PCR high light up-regulated N/A lnc-173 and lnc-225,which are potentially regulated by high light and PIF transcription factors. 25256571 PLNlncRbase
EL0757 lnc-31 Transcriptome analysis mdx muscles up-regulated N/A controlling the differentiation commitment of precursor myoblasts 25512605
EL0759 lnc-508 qRT-PCR heat and cold down-regulated N/A lnc-508 was down-regulated by heat and cold, while lnc-168 was down-regulated by heat and salt in Arabidopsis. 10.3389/fpls.2015.00267 PLNlncRbase
EL0775 lncLGR lncLGR knockdown enhances GCK expression fasted mice up-regulated N/A lncLGR knockdown enhances GCK expression and glycogen storage lncLGR knockdown enhances GCK expression and glycogen storage 26904944
EL0780 lncRNA1329 RNA-Seq/qRT–PCR fruit ripening down-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0781 lncRNA1459 RNA-Seq/qRT–PCR fruit ripening down-regulated N/A Moreover, down-regulation of the expression of some novel intergenic lncRNAs (lncRNA1459 and lncRNA1840) in wild-type tomato fruit induced an obvious delay of fruit ripening. 25948705 PLNlncRbase
EL0782 lncRNA1471 RNA-Seq/qRT–PCR fruit ripening down-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0783 lncRNA1785 RNA-Seq/qRT–PCR fruit ripening down-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0784 lncRNA1840 RNA-Seq/qRT–PCR fruit ripening down-regulated N/A Moreover, down-regulation of the expression of some novel intergenic lncRNAs (lncRNA1459 and lncRNA1840) in wild-type tomato fruit induced an obvious delay of fruit ripening. 25948705 PLNlncRbase
EL0785 lncRNA2.7 RT-PCR human immunodeficiency virus-1 (HIV-1) up-regulated expression stabilizes Complex I, reduced ROS production and inhibited EC apoptosis 20036157
EL0786 lncRNA246 psRNATarget/psRobot phosphate homeostasis N/A N/A LncRNA246 was the eTM of slymiR399, a miRNA that plays an important role in regulating phosphate homeostasis. 25948705 PLNlncRbase
EL0787 lncRNA2943 RNA-Seq/qRT–PCR fruit ripening up-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0788 LncRNA-314 N/A cultivar tomato Heinz1706 and its wild relative LA1589 N/A N/A N/A 26494192
EL0789 lncRNA3294 psRNATarget/psRobot drought N/A N/A In addition, lncRNA3294 was the target of sly-miR169 that is engaged in drought tolerance of tomato. 25948705 PLNlncRbase
EL0790 lncRNA3613 psRNATarget/psRobot N/A N/A N/A LncRNA3613 was the target of sly-miR5304 that has been only identified in solanaceous plants. 25948705 PLNlncRbase
EL0792 lncRNA496 RNA-Seq/qRT–PCR fruit ripening up-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0793 lncRNA504 psRNATarget/psRobot plant immunity N/A N/A Of these three miRNA targets, lncRNA504 was the target of slymiR6024 that was involved in plant immunity. 25948705 PLNlncRbase
EL0794 lncRNA506 RNA-Seq/qRT–PCR fruit ripening up-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0795 lncRNA864 RNA-Seq/qRT–PCR fruit ripening up-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0796 lncRNA950 RNA-Seq/qRT–PCR fruit ripening up-regulated N/A To investigate whether these differentially expressed lncRNAs are engaged in fruit ripening, 10 of them were arbitrarily selected, five from a highly up-regulated group and five from a down-regulated group. The differences in their expression levels observed by RNA-Seq were experimentally validated by qRT–PCR (Fig. 6). 25948705 PLNlncRbase
EL0801 lncRNA-HSVIII N/A spermatocytes N/A N/A upstream and downstream regions of the lncRNA-HSVIII sequence significantly increased Prss42/Tessp-2 promoter activity 27111572
EL0803 lncRNA-Rel microarray, qRT-PCR bone marrow-derived macrophages (BMDMs) N/A expression Many identified LPS-regulated lncRNAs, such as lncRNA-Nfkb2 and lncRNA-Rel, locate near to immune response protein-coding genes. 25652569
EL0804 lncRNA-αGT loss of function experiments N/A N/A N/A promotes full activation of adult gene expression in the chicken α-globin domain. by promoting an active chromatin structure. 24196393
EL0812 LOC100129973 microarray, qRT-PCR in the serum and FGF-2 starvation-induced apoptosis of VECs up-regulated N/A lncRNA LOC100129973 upregulated the expression of two apoptosis repressors gene 26887505
EL0815 LOC100288798 RT-qPCR and RNA-seq haploid KBM7 cells N/A expression Expression analysis from RNA-seq data shows significant deregulation of 41 protein-coding genes upon LOC100288798 truncation. 26662309
EL0817 LOC101211037 Northern blot cotyledons down-regulated N/A The expression of the CR20 gene responded strongly to exogenous cytokinins in excised cotyledons of cucumber, and the level of expression changed in association with phenomena that have been to postulated to involve cytokinins, such as aging of leaves, greening, and responses to wounding. The level of the CR20 transcript decreased during the early phase of greening and soon after the wounding of cotyledons. The levels were much lower in young leaves than in mature or senescent leaves. Cytokinins are thought to control greening and aging of leaves and to mediate responses to wounding. (Teramoto et al., 1996) The CR20 RNA is a product of a cytokinin responsive gene that is repressed in response to cytokinins (plant hormones) or stress conditions and was first isolated from cucumber and later reported in several other plant species. (Szymański et al., 2002) 8980532, 12049667 PLNlncRbase
EL0820 LOC103643717 qRT-PCR/RNA-seq leaves down-regulated N/A This lncRNA was downregulated in drought-stress leaves(see Table S2 for details). 24892290 PLNlncRbase
EL0822 LOC105246506 combined full-length mESC transcriptome genomic mapping data with chromatin immunoprecipitation genomic location maps of the key mESC transcription factors mouse embryonic stem cells (mESCs) N/A Interaction potential roles in pluripotency 20026622
EL0822 LOC105246506 in vitro knowdown, qRT-PCR mESC (mouse embryonic stem cells), MSC (mice mesenchymal stem cells) up-regulated interaction AK141205 positively promoted CXCL13 expression via acetylation of H4 histone in the promoter region;In summary, we report a completely novel role of AK141205/CXCL13 as a regulator of OGP-induced osteogenic differentiation of SMCs. Our finding provides a potential therapeutic targeting of AK141205 for enhancing disease-treatment effect of SMCs. (PMID:26321662). When overexpressed, AK141205 led to an increase in Oct4 mRNA and to a corresponding up-regulation of endodermal markers, in addition to initiating meso- and ectodermal differentiation. (PMID:20026622). 26321662; 20026622
EL0826 LOC105435934 RT-PCR cotyledons up-regulated N/A The CsM10 gene was not expressed in the root tissues, but was expressed in the cotyledons. Originating in cucumber floral buds isolated by differential display and differential hybridization. The CsM10 transcript levels in the apical tissues varied with different seedling developmental stages. CsM10 expression does not depend on phytohormones. CsM10 is related to male sex differentiation in the cucumber. (Jeongki et al., 2005) CsM10 was isolated using differential display reverse transcription PCR, which showed differential expression patterns in different tissues, seedling developmental stages and photoperiods. CsM10 habours a 179 bp sequence with high sequence homology to a family of abiotic stress-associated ncRNAs known as the CR20-GUT15-Related (CGR) family, suggesting a role in the regulation of gene expression. (Au et al., 2011) 21525783 PLNlncRbase
EL0832 LOC548136 RT-PCR Nodule formation up-regulated N/A The polycistronic nature of enod40 mRNA was recently demonstrated biochemically, with in vitro translation in wheat germ extracts resulting in the de novo synthesis of two peptides of 12 and 24 amino acid residues, subsequently immunoprecipitated by antipeptide antibodies. Additionally, these peptides were shown to specifically bind sucrose synthase (SuSy), thus implicating them in the regulation of SuSy activity and/or its intracellular targeting. 12930950 PLNlncRbase
EL0834 LpENOD40 RT-PCR stems down-regulated N/A The LpENOD40 transcript encodes a putative dodecapeptide, similar to that identified in ENOD40s from leguminous plants and other dicots, and also to ENOD40s from monocots. high level of LpENOD40 gene transcript was found expressed in stem tissue. lower level was detected in leaves and only a very low expression in flowers of perennial ryegrass. No LpENOD40 transcript was detected in roots. 12872490 PLNlncRbase
EL0853 MALAT1 Depletion of MALAT1 or overexpression N/A N/A N/A MALAT1 regulates AS by modulating the levels of active SR 20797886
EL0853 MALAT1 knockdown, siRNA human fetal osteoblastic cell line hFOB 1.19 up-regulated expression RANKL, binding to its receptor RANK, inhibited cell proliferation via MALAT1 upregulation in osteoblast cells in vitro. 25817340
EL0853 MALAT1 N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL0853 MALAT1 nuclear magnetic resonance and Förster resonance energy transfer N/A N/A mutation An m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). This m(6)A-dependent regulation of protein binding through a change in RNA structure, termed "m(6)A-switch", affects transcriptome-wide mRNA abundance and alternative splicing. The m(6)A-modified hairpin has a predisposed conformation that resembles the hairpin conformation in the RNA-HNRNPC complex more closely than the unmodified hairpin. 26343757
EL0853 MALAT1 TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated interaction The lncRNA MALAT1 and SOX2OT were induced in both TK6 and WTK1 cells 23698766
EL0854 Malat1 compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
EL0854 Malat1 knock-down, DNA microarray analysis hippocampal neurons Up-regulated regulation modulates the recruitment of SR family pre-mRNA-splicing factors 20729808
EL0854 Malat1 Northern blot,knockdown,RNA-seq a Malat1 loss-of-function genetic model N/A interaction Malat1 is not essential for mouse pre- and postnatal development. However, among a small number of genes that were dysregulated in adult Malat1 knockout mice, many were Malat1 neighboring genes, thus indicating a potential cis-regulatory role of Malat1 gene transcription. a potential cis-regulatory role of Malat1 gene transcription. 22840402
EL0857 MAR RT-PCR flower and leaf development up-regulated N/A MAR(multiple-function-associated mlncRNA) could be involved in multiple complex networks in P.ginseng. The transcripts of MAR could be detected in all tissues analyzed at various levels with the highest in flowers, followed by leaves. It indicates the importance of MAR in flower and leaf development under normal growth conditions. 25040236 PLNlncRbase
EL0858 Maternal somatic nucleus RNAs N/A N/A N/A expression The degree of excision inhibition correlates with the copy number of the maternal internal eliminated sequences (iess), but each ies shows a characteristic inhibition efficiency. 9819394
EL0860 Mdrl knockdown N/A N/A interaction MDRL affects the processing of miR-484 primary transcript in nucleus and regulates the mitochondrial network by targeting miR-361 and miR-484. MDRL inhibits mitochondrial fission and apoptosis by downregulating miR-361, which in turn relieves inhibition of miR-484 processing by miR-361. 25057983
EL0861 MEG3 RT-qPCR macrophages N/A interaction Knockdown of MEG3 in macrophages resulted in induction of autophagy and enhanced eradication of intracellular M. bovis BCG. 26757825
EL0861 MEG3 The luciferase reporter assay and RIP assay EPCs of subjects with MetS up-regulated N/A Pioglitazone up-regulated MEG3 expression to protect EPCs via decreasing miR-140-5p expression and increasing HDAC7 expression in MetS 26898430
EL0862 Meg3 compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
EL0862 Meg3 Northern blot hybridizations N/A N/A expression None of the atg codons of these orfs is in the context of a strong kozak consensus sequence for initiation of translation, suggesting that gtl2 might function as an rna. primary gtl2 transcripts are differently processed in various cell types during development. 9626496
EL0863 MEG8 N/A rat brain N/A expression Despite the finding that bsr rna appears to be conserved only among the rattus species, the specific expression pattern of bsr rna suggests that it might have some role in the rat cns. 10095072
EL0863 MEG8 N/A N/A N/A locus This host gene, which encodes a previously reported noncoding rna, bsr, spans tandemly repeated 0.9-kilobase units including the snorna-containing intron. 11346658
EL0865 MHM expression analysis and retroviral-mediated mis-expression,Northern blot,Whole mount in situ hybridization chicken embryo N/A N/A MHM has a role in chicken normal embryonic development, including gonadal sex differentiation. 22546690
EL0866 MHM-lncRNA N/A N/A N/A expression The mhm region is transcribed only in the female from the particular strand into heterogeneous, high molecular-mass, non-coding rna, which is accumulated at the site of transcription, adjacent to the dmrt1 locus, in the nucleus. 11321370
EL0869 MIAT knockdown,cross-link RNA precipitation analysis neuroblastoma cell line Neuro2A down-regulated interaction Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies. 25145264
EL0869 MIAT RT-PCR, knockdown cataractous lens epithelial cells, plasma fraction of whole blood and aqueous humor of cataract patients up-regulated interaction MIAT knockdown could affect the proliferation, apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress. MIAT knockdown could repress tumour necrosis factor-α-induced abnormal proliferation and migration of HLECs, suggesting a potential role of MIAT in PCO-related pathological process. MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536
EL0869 MIAT TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression The MIAT and PIWIL1 were upregulated in WTK1 cells. 23698766
EL0870 Miat combined full-length mESC transcriptome genomic mapping data with chromatin immunoprecipitation genomic location maps of the key mESC transcription factors mouse embryonic stem cells (mESCs) N/A Interaction potential roles in pluripotency 20026622
EL0870 Miat IRES-GFP fusion approach mouse retinal cell up-regulated regulation regulating mammalian retinal cell fate specification 20459797
EL0871 MIAT Northern blot analysis and RNase H treatment, In situ hybridization, Immunoprecipitation and RT-PCR E5 embryonic chicken brain N/A N/A The tandem UACUAAC Gomafu RNA repeats bind to the SF1 splicing factor with a higher affinity than the divergent branch point sequence in mammals, which affects the kinetics of the splicing reaction in vitro. 21463453
EL0875 Mir124a-1hg SAGE, in situ hybridization developing retina N/A expression Multiple transcripts that were evolutionarily conserved that did not appear to encode open reading frames of more than 100 amino acids in length ("noncoding rnas") were found to be dynamically and specifically expressed in developing and mature retinal cell types. 15226823
EL0880 MIR31HG N/A and in human Duchenne muscular dystrophy (DMD) myoblasts up-regulated N/A controlling the differentiation commitment of precursor myoblasts 25512605
EL0886 mlncR1 qRT-PCR leaves up-regulated N/A mlncR1 is abundant in leaves. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type A mlncRNAs, including mlncR1, mlncR2 and mlncR15, showed less than 2-fold changes between any two time-points. These mlncRNAs appears to be not responsive to cold. 22233149 PLNlncRbase
EL0887 mlncR1 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0888 mlncR10 qRT-PCR leaves up-regulated N/A mlncR10 is abundant in leaves, response to cold stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. The highest level was reached, for most type C mlncRNAs, At 1 h after stress, or in a few cases, at 5 (mlncR30) or 10 hours (mlncR10). 22233149 PLNlncRbase
EL0889 mlncR10 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0890 mlncR11 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0891 mlncR12 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0892 mlncR13 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0893 mlncR13 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0894 mlncR14 qRT-PCR leaves and roots up-regulated N/A Higher in leaves and roots than stems and flowers. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0895 mlncR14 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0896 mlncR15 qRT-PCR leaves and stems up-regulated N/A mlncR15 exhibit high expression in leaves and stems compared with that in flowers and roots. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type A mlncRNAs, including mlncR1, mlncR2 and mlncR15, showed less than 2-fold changes between any two time-points. These mlncRNAs appears to be not responsive to cold. 22233149 PLNlncRbase
EL0897 mlncR15 qRT-PCR methyl jasmonate down-regulated N/A This lncRNA is response to MeJA treatment in S. miltiorrhiza. (to see Fig 7 for details). 25601000 PLNlncRbase
EL0898 mlncR16 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0899 mlncR16 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0900 mlncR17 qRT-PCR roots up-regulated N/A mlncR17 is expressed mainly in roots. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type B, such as mlncR17 and mlncR21, exhibited an immediate decrease after treatment for 1 hour. The decrease continued for at least 10 hours and then some of them, such as mlncR21, showed a trend of recovering to the level in untreated tissues. 22233149 PLNlncRbase
EL0901 mlncR17 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0902 mlncR18 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0903 mlncR18 qRT-PCR methyl jasmonate down-regulated/up-regulated N/A Interestingly, the expression of mlncR18 fluctuated from time-point to time-point. It was significantly down-regulated at the time-point of 24-h treatment, while up-regulated at the time-point of 36-h treatment. These results suggest the significance of mlncRNAs in response to MeJA treatment in S. miltiorrhiza. 25601000 PLNlncRbase
EL0904 mlncR19 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0905 mlncR2 qRT-PCR leaves and roots up-regulated N/A Higher in leaves and roots than stems and flowers. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type A mlncRNAs, including mlncR1, mlncR2 and mlncR15, showed less than 2-fold changes between any two time-points. These mlncRNAs appears to be not responsive to cold. 22233149 PLNlncRbase
EL0906 mlncR2 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0907 mlncR20 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0908 mlncR21 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type B, such as mlncR17 and mlncR21, exhibited an immediate decrease after treatment for 1 hour. The decrease continued for at least 10 hours and then some of them, such as mlncR21, showed a trend of recovering to the level in untreated tissues. 22233149 PLNlncRbase
EL0909 mlncR22 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). The level of group I mlncRNAs, such as mlncR22, kept constant within the first 10 hours of dehydration stress and then increased at 24 hours, showing a relatively slow response. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0910 mlncR23 qRT-PCR roots up-regulated N/A mlncR23 is abundant in leaves. Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR23 showed much quicker responses to dehydration stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0911 mlncR24 qRT-PCR leaves up-regulated N/A mlncR24 is expressed mainly in roots. Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR24 showed much quicker responses to dehydration stress. mlncR24 was induced at 1 hour of stress and then immediately down regulated to far below the level in untreated tissues. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0912 mlncR25 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0913 mlncR26 qRT-PCR leaves and roots up-regulated N/A Higher in leaves and roots than stems and flowers. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0914 mlncR27 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0915 mlncR28 qRT-PCR leaves and stems up-regulated N/A mlncR28 exhibit high expression in leaves and stems compared with that in flowers and roots. Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR28 showed much quicker responses to dehydration stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0916 mlncR29 qRT-PCR leaves up-regulated N/A mlncR29 is abundant in leaves, mlncR29 showed response to cold stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0917 mlncR3 qRT-PCR leaves and roots up-regulated N/A Higher in leaves and roots than stems and flowers. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0918 mlncR3 qRT-PCR methyl jasmonate up-regulated N/A This lncRNA is response to MeJA treatment in S. miltiorrhiza.(to see Fig 7 for details). 25601000 PLNlncRbase
EL0919 mlncR30 qRT-PCR leaves up-regulated N/A mlncR30 is abundant in leaves. Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR30 showed much quicker responses to dehydration stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. The highest level was reached, for most type C mlncRNAs, At 1 h after stress, or in a few cases, at 5 (mlncR30). After reaching to a maximum, the mlncRNA levels quickly declined to near, or in most cases, far below the levels in untreated tissues. mlncR30 was induced at 1 hour of stress and then immediately down regulated to far below the level in untreated tissues. 22233149 PLNlncRbase
EL0920 mlncR31 qRT-PCR roots down-regulated N/A mlncR31, seems to play a role in post-transcriptional regulation of the corresponding protein-coding genes. It is evidenced by the negative correlation of expression between mlncR31 and the SPS gene after 5 hours of stress. 22233149 PLNlncRbase
EL0921 mlncR4 qRT-PCR leaves up-regulated N/A mlncR4 is abundant in leaves, mlncR4 showed response to cold stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0922 mlncR4 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0923 mlncR5 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0924 mlncR5 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0925 mlncR6 qRT-PCR cold up-regulated N/A Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR6 showed much quicker responses to dehydration stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0926 mlncR6 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. mlncR1 and mlncR4 at the time-point of 36-h treatment; mlncR5, mlncR10, mlncR11 and mlncR13 at the time-points of 24- and 36-h treatments; mlncR6 at the time-points of 12-, 36- and 48-h treatments; and mlncR2 at all four points of time. It suggests that the majority of mlncRNAs were down-regulated after MeJA treatment. 25601000 PLNlncRbase
EL0927 mlncR7 qRT-PCR leaves, roots and seeds up-regulated N/A mlncR7, an mlncRNA detected in leaves, stems and flowers of one-year old mature plants, and mlncR11, which was also undetected in the analyzed tissues of mature plants (Figure 7, 8 and 9). D.purpurea mlncR7 exhibited opposite expression patterns with mlncR8, which expressed in plantlets but not in the analyzed tissues of one-year-old plants. It suggests that the expression of both mlncR7 and mlncR8 is developmentally regulated, while their biological functions are distinct. 22233149 PLNlncRbase
EL0928 mlncR7 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0929 mlncR8 qRT-PCR leaves up-regulated N/A D.purpurea mlncR7 exhibited opposite expression patterns with mlncR8, which expressed in plantlets but not in the analyzed tissues of one-year-old plants. It suggests that the expression of both mlncR7 and mlncR8 is developmentally regulated, while their biological functions are distinct. Based on the expression patterns in response to dehydration stress, mlncRNAs can also be roughly classified into 3 groups (Figure 9). Group III consists of 6 mlncRNAs, including mlncR6, mlncR8, mlncR23, mlncR24, mlncR28 and mlncR30. Expression of mlncRNAs in this group was induced at 1 hour of stress and then immediately downregulated to far below the level in untreated tissues. It is similar to the pattern of type C mlncRNAs in response to cold stress. mlncR8 showed much quicker responses to dehydration stress. Based on the expression patterns in response to cold stress, mlncRNAs can be roughly categorized into three major types. Type C mlncRNAs,including mlncR3, mlncR4, mlncR5, mlncR6, mlncR8, mlncR10, mlncR12, mlncR13, mlncR14, mlncR16, mlncR18, mlncR19, mlncR20, mlncR22, mlncR23, mlncR24, mlncR25, mlncR26, mlncR27, mlncR28, mlncR29, mlncR30, accounting for more than 80% or 22 of the total 27 mlncRNAs, showed a rapid increase after treatment. 22233149 PLNlncRbase
EL0930 mlncR8 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0931 mlncR9 qRT-PCR methyl jasmonate down-regulated N/A MeJA(methyl jasmonate) is a significant regulator in plant response to biotic and abiotic stresses. These 15 mlncRNAs are considered as MeJA-responsive mlncRNAs, of which 12 were significantly down-regulated at different time-points of treatment, such as mlncR7,mlncR8, mlncR9, mlncR14, mlncR16 and mlncR17 at the time-point of 24-h treatment. 25601000 PLNlncRbase
EL0935 MsENOD40-1 Southern blot Nodule formation down-regulated N/A ENOD40, an early nodulin gene, is expressed following inoculation with Rhizobium meliloti or by adding R.meliloti-produced nodulation (Nod) factors or the plant hormone cytokinin to uninoculated roots. We isolated two MsENOD40 clones, designated MsENOD40–1 and MsENOD40–2, with distinct promoters from an alfalfa (Medicago sativa cv Chief) genomic library. The promoters were fused to the reporter gene uidA (gus), and the constructs were introduced into alfalfa. We observed that the MsENOD40–1 construct was expressed almost exclusively under symbiotic conditions. Under nonsymbiotic conditions MsENOD40–1 was usually not expressed in the uninoculated root of the transgenic alfalfa plants, but was activated when lateral roots or nodule primordia are initiated. The expression of MsENOD40–1 as well as MsENOD40–2 was induced by BAP or Nod factor treatment, and the extent of induction is similar for both genes (2- to 3-fold), although the basal level of MsENOD40–2 expression is generally higher (Fig. 6). In addition, both genes were also expressed in a similar pattern in roots following treatment with cytokinin or Nod factor for 4d (see Fig. 3, G–Q). 9449836 PLNlncRbase
EL0936 MsENOD40-2 Southern blot Nodule formation down-regulated N/A ENOD40, an early nodulin gene, is expressed following inoculation with Rhizobium meliloti or by adding R.meliloti-produced nodulation (Nod) factors or the plant hormone cytokinin to uninoculated roots. We isolated two MsENOD40 clones, designated MsENOD40–1 and MsENOD40–2, with distinct promoters from an alfalfa (Medicago sativa cv Chief) genomic library. The promoters were fused to the reporter gene uidA (gus), and the constructs were introduced into alfalfa. We observed that the MsENOD40–1 construct was expressed almost exclusively under symbiotic conditions. The MsENOD40–2 construct was transcribed under both symbiotic and nonsymbiotic conditions and in nonnodular and nodular tissues. In contrast, the expression of MsENOD40–2 is likely to be constitutive, because the promoter construct was expressed in the vascular tissues of the root and the stem even in the absence of R. meliloti (see Fig. 3). In addition, the expression of the MsENOD40–2 promoter construct was also detected at the root tip and throughout lateral root development (Fig. 3). Moreover, MsENOD40–2 was expressed in the root tip, including the root cap in some transgenic plants. The expression of MsENOD40–1 as well as MsENOD40–2 was induced by BAP or Nod factor treatment, and the extent of induction is similar for both genes (2- to 3-fold), although the basal level of MsENOD40–2 expression is generally higher (Fig. 6). In addition, both genes were also expressed in a similar pattern in roots following treatment with cytokinin or Nod factor for 4d (see Fig. 3, G–Q). 9449836 PLNlncRbase
EL0939 Msx1os In situ analysis differentiated dental and bone cells, odontoblastic cell line (MO6-G3) N/A N/A The ratio between msx1 sense and antisense rnas is a very important factor in the control of skeletal terminal differentiation. 11390985
EL0939 Msx1os N/A N/A N/A expression The msx1 as rna involvement during tooth development and evidences a new degree of complexity in craniofacial developmental biology: the implication of endogenous as rnas. 16157866
EL0939 Msx1os RT-PCR, Northern-blotting, In situ hybridization dental and bone cells N/A interaction The balance between antisense and sense msx1 mrnas appeared to control msx1 protein levels. 12489151
EL0941 MT1JP applied to 76 pairs of matched normal and cancer tissue samples tumor tissues up-regulated N/A critical factor in restraining cell transformation by modulating p53 translation 26909858
EL0942 Mt4 Northern blot/qRT-PCR roots up-regulated N/A This lncRNAs work as a decoy of miRNAs,and exert their functions by binding miRNAs in a target mimicry mechanism to sequestrate the miRNAs’ regulation roles on their target genes, such as lncRNAs IPS1 and at4. 23726911 PLNlncRbase
EL0943 Mt4 Northern blot/Southern blot roots down-regulated N/A Mt4 gene expression is regulated in response to colonization by mycorrhizal fungi: transcripts were detected in non-colonized roots and levels decreased in M.sativa(alfalfa) roots after colonization by G.versiforme. Transcript levels also decreased during the incomplete interaction between G.versiforme and a M.sativa mycorrhizal minus (myc-) line, indicating that the down-regulation of this gene occurs early during the interaction between the fungus and its host plant. Phosphate levels in the nutrient media also affected the expression of the Mt4 gene: transcripts were present in the roots of plants grown under phosphate-deficient conditions, but were undetectable in the roots of plants grown under phosphate sufficient conditions. Northern blot analyses indicate that Mt4 transcripts are present primarily in roots and barely detectable in stems or leaves. 9207836 PLNlncRbase
EL0944 Mt4 RT-PCR roots up-regulated N/A Mt4 is a cDNA representing a phosphate-starvation-inducible gene from Medicago truncatula that is down-regulated in roots in response to inorganic phosphate (Pi) fertilization and colonization by arbuscular mycorrhizal fungi. The expression of the Mt4 gene in M.truncatula roots is down-regulated systemically by both Pi fertilization and colonization by arbuscular mycorrhizal fungi. Analysis of the expression of the Mt4-like Arabidopsis gene, At4, in wild-type Arabidopsis and pho1, a mutant unable to load Pi into the xylem, suggests that Pi must first be translocated to the shoot for down-regulation to occur. The data from the pho1 and split-root studies are consistent with the presence of a translocatable shoot factor responsible for mediating the systemic downregulation of Mt4-like genes in roots. (Burleigh et al., 1999) Mt4, a phosphate starvation inducible cDNA from Medicago truncatula which is down-regulated in roots in response to phosphate fertilization as well as colonization by arbuscular mycorrhizal (AM) fungi. Expression was highly sensitive to exogenous applications of phosphate fertilizer; transcripts were abundant in roots fertilized with nutrient solution lacking phosphate. Mt4 is the first cDNA reported to show independent regulation by both phosphate and mycorrhizal fungi. Mt4 gene expression exhibited an inverse, exponential correlation with soluble phosphorus levels in the leaves. The Mt4 gene from M.truncatulais the first plant gene identified whose expression is down-regulated by both phosphate starvation and mycorrhizal colonization and as such may provide the means to elucidate the signal transduction pathways involved in these two processes. The phosphate fertilization experiment indicated that Mt4 gene expression in roots was maximal under conditions of P-starvation and dramatically reduced by relatively low levels of phosphate fertilization. The response of Mt4 expression to P-starvation was similar to that of MtPT2, a P-starvation inducible phosphate transporter from M.truncatula. (Burleigh et al., 1998) A cDNA clone (Mt4) was isolated as a result of a differential screen to identify genes showing altered expression during the interaction between Medicago truncatula and the vesicular-arbuscular mycorrhizal (VAM) fungus Glomus versiforme. Mt4 represents a M.truncatula mRNA that contains numerous short open reading frames, the two longest of which are predicted to encode polypeptides of 51 amino acids each. One of these open reading frames shares a short region of identity with a phosphate starvation-inducible gene from tomato. Mt4 gene expression is regulated in response to colonization by mycorrhizal fungi: transcripts were detected in non-colonized roots and levels decreased in both M.truncatula and M.sativa(alfalfa) roots after colonization by G.versiforme. Northern blot analyses indicate that Mt4 transcripts are present primarily in roots and barely detectable in stems or leaves, Thus, Mt4 represents a M.truncatula gene whose expression is regulated in response to both colonization by mycorrhizal fungi and to the phosphate status of the plant. (Burleigh et al., 1997) 9880366, 9207836 PLNlncRbase
EL0945 MtENOD40-1 RT-PCR Nodule formation down-regulated N/A In M.truncatula, knock-down of MtENOD40-1 expression led to a 50% reduction in the number of nodules. To reduce MtENOD40-1 and MtENOD40-2 gene expression, Agrobacterium rhizogenes-mediated RNAi was applied in M.truncatula hairy roots. To this end, one vector (pRRsil401) was designed that is expected to lead to a reduction in expression of MtENOD40-1, and a second vector (pRRsil402) that is expected to lead to a reduction in MtENOD40-2 expression. To knock-down transcription of both genes simultaneously, a third vector (pRRsil4012) was used. MtENOD40-1 as well as MtENOD40-2 is involved in nodule initiation. On roots,in which the expression of both MtENOD40-1 and MtENOD40-2 is reduced, the average number of nodules per root is 1.5 (75% reduction). Thus knocking down of the expression of both genes has an additive effect, suggesting that MtENOD40 acts in a dose-dependent manner. 17452749 PLNlncRbase
EL0946 MtENOD40-2 RT-PCR Nodule formation down-regulated N/A In sections of roots collected 2d post-inoculation, GUS activity was present in dividing cortical cells, indicating that MtENOD40-2 is expressed in cells of the nodule primordium (Fig. 2C). Whole-mount staining for GUS activity of nodules showed that GUS activity is detected near the apex of the nodule and in vascular bundles (Fig. 2D). To localize the site of expression of MtENOD40-2 precisely in the nodule, in situ hybridization using [35S]UTP-labelled antisense MtENOD40-2 RNA was conducted (Fig. 2A, B). This showed that MtENOD40-2 is expressed in cells of the infection zone (Fig. 2B, IZ). Thus, the MtENOD40-2 expression pattern is similar to the MtENOD40-1 expression pattern (Crespi et al., 1994). Furthermore, the GUS expression studies are consistent with the in situ hybridization data, indicating that the 1.8 kb DNA fragment used contains the elements required for the regulation of MtENOD40-2 expression. Based on the combination of expression data and the sequence homology between both genes, it is likely that MtENOD40-2 is functional in nodule initiation and development. 17452749 PLNlncRbase
EL0949 Munc knockdown murine muscle N/A N/A a promyogenic lncRNA that acts directly or indirectly on multiple promoters to increase myogenic gene expression 25403490
EL0953 Myh8 Northern blot, RT-PCR neonatal rat heart N/A expression In the neonatal heart naturally occurring antisense mrna may play a role in the regulation of mhc expression and, therefore, in the control of the energetical and contractile behaviour of the heart. 9632112
EL0971 Nctc1 ChIP, qRT-PCR Myoblasts N/A N/A Nctc1 is co-regulated with Igf2 and H19 and physically interacts with the shared muscle enhancer. In fact, all three co-regulated genes have the potential to interact not only with the shared enhancer but also with each other via their enhancer interactions 23221643
EL0971 Nctc1 N/A N/A N/A expression enhancer function requires transcription in cis of a long non-coding RNA, Nctc1. 23842673
EL0972 NDM29 RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
EL0973 NEAT1 EM observation mammalian cells N/A Interaction Paraspeckle formation is initiated by transcription of the NEAT1 chromosomal locus and proceeds in conjunction with NEAT1 lncRNA biogenesis and a subsequent assembly step involving >40 paraspeckle proteins (PSPs). 25831520
EL0973 NEAT1 knockdown HeLa epithelial adenocarcinoma,WI-38 normal female diploid fibroblast lung,Human EBV-transformed human lymphoblasts,primary mouse embryo fibroblasts N/A mutation Depletion of NEAT1 RNA via RNAi eradicates paraspeckles, suggesting that it controls sequestration of the paraspeckle proteins PSP1 and p54, factors linked to A-I editing. Unlike overexpression of PSP1, NEAT1 overexpression increases paraspeckle number, and paraspeckles emanate exclusively from the NEAT1 transcription site 19217333
EL0973 NEAT1 N/A Human cell N/A N/A paraspeckle formation 20211624
EL0973 NEAT1 N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL0974 Neat1 expression patterns of two long noncoding RNAs; an animal model lacking NEAT1 adult mouse tissues N/A N/A architectural integrity of nuclear bodies 21444682
EL0974 Neat1 expression patterns of two long noncoding RNAs;an animal model lacking NEAT1 adult mouse tissues N/A N/A architectural integrity of nuclear bodies 21444682
EL0974 Neat1 N/A mouse Neuro-2a cell line N/A N/A the least stable lncRNAs is the well-characterized paraspeckle RNA Neat1, Neat1's instability contributes to the dynamic nature of this subnuclear domain. 22406755
EL0974 Neat1 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Neat1 has also been reported to interact with a number of chromatin binding protein/complexes in mouse embryonic stem cells including PRC1, PRC2, JARID1B, ESET and SUV39H1, with the general pattern being interaction with repressors of gene expression 21874018
EL0974 Neat1 RT-PCR, siRNA, RIP 3T3-L1 cells induced to differentiate by a media cocktail of insulin, dexamethasone, and isobutylmethyxanthine (IBMX) down-regulated expression Levels of NEAT1 transcript, measured by RT-PCR, fluctuated in a temporal manner over the course of differentiation that suggested its role in alternative splicing of PPARγ mRNA, the major transcription factor driving adipogenesis. 25437750
EL0976 Nfkb2 microarray, qRT-PCR bone marrow-derived macrophages (BMDMs) N/A expression Many identified LPS-regulated lncRNAs, such as lncRNA-Nfkb2 and lncRNA-Rel, locate near to immune response protein-coding genes. 25652569
EL0985 NORAD N/A previously karyotypically stable cell lines N/A interaction Inactivation of NORAD triggers dramatic aneuploidy in previously karyotypically stable cell lines. 26724866
EL0990 npc15 microarray/qRT-PCR leaves N/A N/A Differential expression of TAS3, npc43, and npc311 in roots and of npc15 and npc156 in leaves was confirmed, as we previously reported using semiquantitative RT-PCR. As the expression of several npcRNAs was affected by environmental stress, we explored the response to salt stress and phosphate starvation in lines overexpressing npc43, npc60, npc311, and npc536. 18997003 PLNlncRbase
EL0991 npc156 Microarray/qRT-PCR leaves up-regulated N/A Differential expression of TAS3, npc43, and npc311 in roots and of npc15 and npc156 in leaves was confirmed, as we previously reported using semiquantitative RT-PCR. As the expression of several npcRNAs was affected by environmental stress, we explored the response to salt stress and phosphate starvation in lines overexpressing npc43, npc60, npc311, and npc536. 18997003 PLNlncRbase
EL0992 npc311 Microarray/qRT-PCR roots down-regulated N/A Differential expression of TAS3, npc43, and npc311 in roots and of npc15 and npc156 in leaves was confirmed, as we previously reported using semiquantitative RT-PCR. As the expression of several npcRNAs was affected by environmental stress, we explored the response to salt stress and phosphate starvation in lines overexpressing npc43, npc60, npc311, and npc536. 18997003 PLNlncRbase
EL0993 npc33 RT-PCR phosphate starvation down-regulated N/A For the phosphate starvation assays, the up-regulation of npc43 and npc536 and the down-regulation of npc33 were confirmed (Fig. 5A). 18997003 PLNlncRbase
EL0994 npc34 RT-PCR roots up-regulated N/A Expression levels of npcRNAs 34 and 60 increased severalfold in phosphate-starved and in 6-benzylaminopurine (BA)-treated roots. 16500993 PLNlncRbase
EL0995 npc351 RT-PCR stems up-regulated N/A The majority of siRNAs deriving from this npcRNAs are 24 nt long and map to both DNA strands of the npcRNA region, suggesting that these npcRNAs correspond to 24-nt-small RNA precursors. Expression analysis in different organs revealed that npc351 is enriched in stems. Whereas the npc375 and npc523 levels appeared unchanged in the rdr2 rdr6 double mutant, the npc34 and npc351 were up-regulated in both seedlings and flowers of rdr2 rdr6 (Fig. 1, right panel), suggesting that RDR2 or RDR6 produces a dsRNA from these npcRNAs, consistent with small RNA production from both DNA strands of these loci. 18997003 PLNlncRbase
EL0996 npc375 RT-PCR flowers up-regulated N/A The majority of siRNAs deriving from these five npcRNAs are 24 nt long and map to both DNA strands of the npcRNA region, suggesting that these npcRNAs correspond to 24-nt-small RNA precursors. Expression analysis in different organs (Fig. 1) revealed that npc351 is enriched in stems and npc34 in aerial parts, whereas npc375 and npc523 show maximal levels in flowers. 18997003 PLNlncRbase
EL0997 npc43 Northern blot/RT-PCR phosphate starvation up-regulated N/A For the phosphate starvation assays, the up-regulation of npc43 and npc536 and the down-regulation of npc33 were confirmed (Fig. 5A). 18997003 PLNlncRbase
EL0998 npc48 qRT-PCR leaf serration and flowering time up-regulated N/A Overexpressing the npc48 showed drastic developmental anomalies, including an increase in the rosette diameter, leaf serration, and a delay in the flowering time compared with wild-type plants (Fig. 6A). Overexpression of npc48 led to leaf serration, a phenotype that has been observed in several Arabidopsis mutants such as se or ago1. Quantitative RT-PCR analysis of npc48 accumulation revealed that all transgenic lines exhibiting this phenotype overaccumulated npc48 (Supplemental Fig. 3). 18997003 PLNlncRbase
EL0999 npc523 RT-PCR flowers up-regulated N/A The majority of siRNAs deriving from these five npcRNAs are 24 nt long and map to both DNA strands of the npcRNA region, suggesting that these npcRNAs correspond to 24-nt-small RNA precursors. Expression analysis in different organs (Fig. 1) revealed that npc351 is enriched in stems and npc34 in aerial parts, whereas npc375 and npc523 show maximal levels in flowers. Specific oligonucleotides for real-time PCR studies could not be obtained for npc520. Whereas the npc375 and npc523 levels appeared unchanged in the rdr2 rdr6 double mutant. 18997003 PLNlncRbase
EL1000 npc531 qRT-PCR dcl1-9 mutant up-regulated N/A In addition to npcRNAs corresponding to conserved miRNAs, the npc531, which was not previously linked to RNA silencing mechanisms or known to encode a miRNA, also was upregulated in a dcl1-9 mutant, a difference confirmed using quantitative RT-PCR (Fig. 4A, left panel). No known miRNAs map to this gene, suggesting that, alternatively, it could be the target of a miRNA. We identified a putative miR319 target site in npc531 (Fig. 4A, right panel), but 5 RACE-PCR analyses did not reveal any specific cleavage of this transcript in this site (data not shown). 18997003 PLNlncRbase
EL1001 npc536 RT-PCR phosphate starvation, salt up-regulated N/A npc536 was up-regulated in phosphate starvation. overaccumulate npc536 displayed heightened root growth under salt stress conditions. Transformed plants over-expressing npc536 showed heightened root growth under salt stress conditions, with increased primary root growth and secondary root length; No phenotype could be observed in mutants that carry T-DNA insertions within npc536; In response to certain abiotic stresses such as drought or cold treatment, the root expression of these two genes (AT1G67930 and npc536) tends to be anti-correlated (Pearson correlation coefficient of -0.636 and -0.983, respectively). However, accumulation of the AT1G67930 transcript was not significantly modified in plants over-expressing npc536 or in npc536 mutants. (Ben et al., 2009) npc536 has a large dynamic variation of expression across a wide range of tissue and hormonal, biotic, or abiotic treatment. npc536 exists in the antisense strand of a Golgi-transport complex related protein. 35S::npc536 transformants displayed heigh tened root growth under salt stress conditions. (Matsui et al., 2013) 18997003, 24252906 PLNlncRbase
EL1002 npc60 Northern blot/RT-PCR salt up-regulated N/A Salt stress resulted in a dramatic 100-fold increase in npc60 accumulation. For npc60, npc82, and npc536, the change in expression observed after 3h of NaCl treatment was maintained after 24h (Fig. 5B), whereas for npc72 the induction was transient. Expression levels of npcRNAs 34 and 60 increased severalfold in phosphate-starved and in 6-benzylaminopurine (BA)-treated roots(Plant Physiol.2006 Apr;140(4):1192-204.). 18997003 PLNlncRbase
EL1003 npc78 RT-PCR dcl1 mutant up-regulated N/A The npcRNA78 gene contains the miR162 sequence in an alternative intron and corresponds to the MIR162a locus. Although DICER-LIKE 1 (DCL1) mRNA is known to be regulated by miR162-guided cleavage, its level does not change in a mir162a mutant. Alternative splicing of npcRNA78 leads to several transcript isoforms, which all accumulate in a dcl1 mutant. This suggests that npcRNA78 is a genuine substrate of DCL1 and that splicing of this microRNA primary transcript and miR162 processing are competitive nuclear events. 16500993 PLNlncRbase
EL1004 npc82 Northern blot/RT-PCR NaCl treatment up-regulated N/A For npc60, npc82, and npc536,the change in expression observed after 3 h of NaCl treatment was maintained after 24 h (Fig. 5B), whereas for npc72 the induction was transient (Fig. 5B). 18997003 PLNlncRbase
EL1005 npc83 RT-PCR N/A N/A N/A Some were already characterized small RNA precursors, such as the tasiRNA precursor TAS3 (npc41) or the MIR162A precursor (npc78) (Hirsch et al. 2006). The npc83 and npc521 corresponded to the miRNA precursors MIR869A and MIR160C, respectively. Among seven known miRNA precursors spotted on the RIBOCHIP, six (MIR160C, MIR162A, MIR164B, MIR166A, MIR166B, and MIR168A) were up-regulated in dcl1 inflorescences, consistent with DCL1-processed conserved miRNAs. In contrast, the nonconserved MIR869A precursor (npc83) did not overaccumulate in dcl1. This miRNA precursor has an unusually stable secondary structure. 18997003 PLNlncRbase
EL1009 NR024118 lncRNAs array, qPCR Ang II-treated cardiac fibroblasts down-regulated expression Ang II dynamically regulated the expression of lncRNA-NR024118 and Cdkn1c in cardiac fibroblasts, indicating the potential role of NR024118 in cardiac fibroblasts. 24817929
EL1009 NR024118 N/A dult rat cardiac fibroblasts down-regulated expression Our current studies showed that the decrease of lncRNA-NR024118 and Cdkn1c induced by Ang II is mediated by AT1 receptor-dependent not AT2 receptor-dependent, which is helpful to understand the molecular mechanism of Ang II receptors in adult rat cardiac fibroblasts. 25979571
EL1010 NRAV overexpression human cells or transgenic mice down-regulated expression A lncRNA that we call negative regulator of antiviral response (NRAV) was dramatically downregulated during infection with several viruses, we ectopically expressed NRAV in human cells or transgenic mice and found that it significantly promotes influenza A virus (IAV) replication and virulence. 25525793
EL1015 nta-eTMX27 N/A N/A N/A interaction We identified a microRNA (nta-miRX27) and also a lncRNA (nta-eTMX27) as an endogenous target mimicry (eTM) in tobacco targeting the nicotine biosynthesis key gene QPT2 encoding quinolinate phosphoribosyltransferase (QPT) and thereby regulating the nicotine content. 27172239
EL1016 NtENOD40-1 RT-PCR nodule initiation up-regulated N/A Whereas Rhizobial Nod-factor signaling sets the process of nodulation in action, the process is further regulated by the phytohormones ethylene, cytokinin and auxin. ENOD40-1 expression is induced by Nod-factors or cytokinin in legumes suggesting that these could be candidate interactors of ENOD40. 1701140 PLNlncRbase
EL1017 NUTF2P3 N/A N/A up-regulated interaction After downregulating lncRNA-NUTF2P3-001, the proliferation and invasion of pancreatic cancer cell are significantly inhibited both in vitro and vivo, accompanying with decreased KRAS expression. Data from pancreatic cancer patients show a positive correlation between lncRNA-NUTF2P3-001 and KRAS, which is associated with advanced tumor stage and worse prognosis. lncRNA-NUTF2P3-001 and miR-3923 can be applied as novel predictors and therapeutic targets for pancreatic cancer. 26755660
EL1018 ObENOD40 RT-PCR Nodule formation up-regulated N/A ENOD40 has been proposed as playing a pivotal role in the organogenesis of legume root nodules. ObENOD40, in which an XbaI fragment (approximately 640 bp) contained a sequence for encoding an oligopeptide that is highly conserved in all legume ENOD40s. 10363365 PLNlncRbase
EL1020 OIP5-AS1 N/A human cervical carcinoma HeLa cells N/A interaction OIP5-AS1 reduces cell proliferation. OIP5-AS1 serves as a sponge or a competing endogenous (ce)RNA for HuR, restricting its availability to HuR target mRNAs and thereby repressing HuR-elicited proliferative phenotypes. 26819413
EL1024 OsIPS1 qRT-PCR roots down-regulated N/A OsIPS1 is a noncoding RNA. IPS1 sequesters miR399 (microRNA 399), which negatively regulates the gene PHO2 at the post-transcriptional level. 19566645 PLNlncRbase
EL1025 osk N/A Drosophila N/A mutation The Drosophila oskar (osk) mRNA is unusual in having both coding and noncoding functions. The 3' UTR also mediates the noncoding function of osk, which is essential for progression through oogenesis. Mutations which most strongly disrupt the noncoding function are positioned in a short region (the C region) near the 3' end of the mRNA, in close proximity to elements required for activation of translation. 26433064
EL1026 OsPI1 qRT-PCR phosphate starvation up-regulated N/A OsPI1 cloned from rice roots. The OsPI1 gene was rapidly induced by phosphate starvation in both shoots and roots. When phosphate was supplied to phosphate-deficient plants, the OsPI1 transcripts rapidly disappeared. suggested that OsPI1 acts as riboregulator, that is, it binds with other molecules under phosphate starvation and regulates their function. 10.1046/j.1469-8137.2003.00748.x PLNlncRbase
EL1046 PANDAR N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL1048 Paupar knockdown N2A mouse neuroblastoma cells N/A N/A Knockdown of Paupar disrupts the normal cell cycle profile of neuroblastoma cells and induces neural differentiation. Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein. Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is Modulated by Paupar transcript levels. 24488179
EL1058 PCGEM1 N/A osteoarthritic human synoviocytes up-regulated interaction Exogenous overexpression of PCGEM1 inhibited apoptosis, induced autophagy, and stimulated the proliferation of human synoviocytes. The increased expression of PCGEM1 in human synoviocytes also suppressed the expression of miR-770. Transfection of the miR-770 precursor resulted in reduced proliferation, and induced apoptosis of human synoviocytes. This effect of miR-770 expression was reversed by co-introduction of PCGEM1. PCGEM1 act as sponge lncRNA for miR-770 that regulates proliferation/apoptosis and autophagy, and suggest PCGEM1 as possible target for OA therapy. 26340084
EL1064 pGmENOD40 RT-PCR root nodules up-regulated N/A pGmENOD40 RNA is present at a high level in nodules and at a low level in uninoculated roots, stems and flowers. And induced in the nodule primordium and the region of the root pericycle opposite the primordium, and in mature nodules these genes are expressed in the pericycle of the vascular bundle. (Matvienko et al., 1994) In pea roots, ENOD40 is expressed in the region opposite the protoxylem poles, which is also the region where nodules form. This suggests that ethylene provides positional information for nodule primordia to form opposite protoxylem poles. (Vleghels et al., 2003) 7948896, 14508686 PLNlncRbase
EL1066 PHO84 antisense transcripts Western Blotting,Northern Blotting,Epistasis and chromatin immunoprecipitation Yeast strains N/A interaction knockdown of antisense production prevents PHO84 gene repression, even in the absence of Rrp6. 18022365
EL1068 Pinc microarray, qRT-PCR inguinal mammary glands N/A mutation PINC may contribute to the developmentally mediated changes previously observed in the terminal ductal lobular unit-like structures of the parous gland 16574773
EL1070 PINK1-AS knockdown, qT-PCR preadipocytes and adipocytes down-regulated interaction PU.1 AS lncRNA promotes adipogenesis through preventing PU.1 mRNA translation via binding to PU.1 mRNA to form mRNA/AS lncRNA duplex in preadipocytes. 23749759
EL1072 Platr14 weighted gene coexpression network analysis mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) down-regulated expression Among these, we show that acute depletion of Platr14 using antisense oligonucleotides impacts the differentiation- and development-associated gene expression program of ESCs. 26048247
EL1075 pncRNA-D RNA pull down assay N/A N/A interaction N/A 26816614
EL1080 pouBW1 qPCR different tissues of Gushi chickens and Anka broilers at different development stages N/A mutation A single nucleotide polymorphism (SNP) at the 5'-end of the gene was identified. The SNP was significantly (P < 0.05) associated with leg muscle weight, chest breadth, sternal length and body weight in chickens at 1 day, 4 weeks and 6 weeks of age. 26643990
EL1084 Prep knockdown; overexpression primary ovarian granulosa cell and a hepatic cell line N/A interaction this lncRNA could play a role in the POP gene activation in the granulosa cell. 24369296
EL1085 PRINS N/A renal tubular cells of wild type mice up-regulated interaction Among HIF-1α dependent LncRNAs, PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress) was significantly up regulated in hypoxic conditions and had specific interaction with RANTES as confirmed through reporter assay. 26725683
EL1086 Prion-associated RNAs N/A N/A N/A interaction These interactions between shsrnas and hrprp suggest possible roles of rnas in the modulation of prp structure and perhaps disease development. 12946346
EL1091 PsiLNCRNA00268512 N/A perennial plants N/A interaction PsiLNCRNA00268512 regulates miR396e levels by acting as a target mimic. 26712827
EL1093 psvA antisense RNA excess transcription, inhibition of RNA synthesis vegetative cells N/A expression The inhibition of rna synthesis during disaggregation prevents destabilization of the mrna. 1555240
EL1099 Ptgs2os2 qPCR dendritic cells, macrophages, splenocytes from Listeria-infected mice N/A N/A mediates both the activation and repression of distinct classes of immune genes.Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. 23907535
EL1099 Ptgs2os2 RNA-seq, qRT-PCR innate immune cells N/A expression A highly inflammatory inducible lncRNA that is responsible for activation and repression of distinct immune genes. 26803630
EL1101 PU.1 AS RT-PCR, endogenous ribonuclease protection assay porcine subcutaneous adipose, heart, liver, spleen, lympha, skeletal muscle and kidney tissues N/A expression PU.1 AS lncRNA (vs. its mRNA translation) promotes adipogenesis through the formation of a sense-antisense RNA duplex with PU.1 mRNA. 25691151
EL1109 RBM5-AS1 N/A N/A N/A expression We identified a 326 bp bone marrow cdna fragment (termed je2) that suppresses, upon transfection, cd95-mediated apoptosis in jurkat t cells. 10949932
EL1109 RBM5-AS1 RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
EL1111 RD29A Northern blot/RT-PCR/Microarray drought up-regulated N/A Fig. 3A shows an fSAT of the drought-inducible gene, RD29A and the novel drought-inducible antisense TUs. The presence of novel drought-inducible TUs on the antisense strand was confirmed by real-time RT-PCR and Northern analyses using strand-specific RNA probes (Figs. 3B, 3C); The RD29A and CYP707A1 lancRNAs that were simultaneously accumulated with sense mRNAs, were accumulated by drought- and ABA treatments(Plant Cell Physiol.2008, 49, 1135–1149.). 18625610 PLNlncRbase
EL1115 RHOXF1P1 LncRHOXF1 knockdown using siRNAs trophectoderm and primitive endoderm cells of human blastocyst-stage embryos up-regulated N/A regulates the host response to viral infections in human placental progenitor cells 27066803
EL1116 Rian knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Rian was also found to interact with a number of other chromatin binding protein(s)/complexes in mouse embryonic stem cells including PRC1, JARID1B, JARID1C and CBX3, with the general pattern being interaction with repressors of gene expression. 21874018
EL1117 Rmrp N/A Rmrp gene mutation in mice N/A mutation A targeted Rmrp gene mutation in mice, corresponding to a gene mutation in cartilage-hair hypoplasia patients, altered lncRNA chromatin occupancy, and reduced the DDX5-RORγt interaction and RORγt target gene transcription 26675721
EL1119 RMST N/A anterior neural tube up-regulated expression Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area 20062813
EL1119 RMST tsRMST knockdown cells human pluripotent stem cells up-regulated N/A disruption of tsRMST expression in hESCs results in the up-regulation of WNT5A, EMT, and lineage-specific genes/markers 27090862
EL1120 RN7SK Immunoprecipitation,Immunofluorescence microscopy,FISH analysis, HeLa cell N/A interaction N/A 17381310
EL1120 RN7SK N/A N/A N/A interaction The 7sk/p-tefb interaction may serve as a principal control point for the induction of cellular and hiv-1 viral gene expression during stress-related responses. 11713532
EL1120 RN7SK N/A N/A N/A interaction The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii. 11713533
EL1120 RN7SK RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
EL1121 RN7SL1 a solid phase radioimmune assay N/A N/A expression Cellular function of 7sl-rna is as a part of srp. 6196367
EL1121 RN7SL1 N/A N/A N/A expression The rna is closely identified with the small cytoplasmic 7sl rna and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle. 6181418
EL1129 RNY1 Specific degradation late-G(1)-phase human cells down-regulated mutation Specific degradation of hY RNAs leads to the inhibition of semiconservative DNA replication in late-G(1)-phase template nuclei. This inhibition is negated by resupplementation of hY RNAs. All four hY RNAs (hY1, hY3, hY4, and hY5) can functionally substitute for each other in this system. Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication. Degradation of hY1 RNA in asynchronously proliferating HeLa cells by RNA interference reduced the percentages of cells incorporating bromodeoxyuridine in vivo. 16943439
EL1130 roX1 capture hybridization analysis of RNA targets (CHART) N/A N/A N/A roX2, a well-studied ncRNA involved in dosage compensation in Drosophila. 22143764
EL1130 roX1 N/A N/A N/A mutation Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions. 26773003
EL1131 roX2 N/A N/A N/A mutation Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions. 26773003
EL1138 AL353732.1 global lncRNA expression analysis urine of patients with acute T cell-mediated renal allograft rejection up-regulated expression RP11-354P17.15-001 was associated with higher decline in glomerular filtration rate 1 year after transplantation. 26506418
EL1141 RP11-395P13.3-001 global lncRNA expression analysis urine of patients with acute T cell-mediated renal allograft rejection up-regulated expression N/A 26506418
EL1146 RP11-457M11.2 N/A N/A N/A N/A N/A 26325208
EL1153 RP11-766N7.3 LncRNA microarray Dermal papilla (DP) cells up-regulated expression RP11-766N7.3, H19 and HOTAIR are specific lncRNAs that were aberrantly expressed in DP cells and played an important role in regulating Wnt signaling 25285630
EL1172 Rubie positional cloning wildtype SWR/J mice N/A N/A Rubie is the gene mutated in Ecl mice, that it is involved in regulating inner ear expression of Bmp4, and that aberrant Bmp4 expression contributes to the Ecl phenotype. 22253730
EL1175 RZE1 single molecule fluorescent in situ hybridization (smFISH) Cryptococcus neoformans N/A interaction A long non-coding RNA (lncRNA) RZE1 functions upstream of ZNF2 in regulating yeast-to-hypha transition. This lncRNA controls Cryptococcus yeast-to-hypha transition through regulating the key morphogenesis regulator Znf2. 26588844
EL1176 SALRNA1 RNA-Seq, reverse transcription (RT) and real-time,quantitative (q)PCR human diploid WI-38 fibroblasts, 'old' fibroblasts (PDL 52) N/A N/A delay senescence, reducing SAL-RNA1 levels enhanced the appearance of phenotypic traits of senescence, including an enlarged morphology, positive β-galactosidase activity, and heightened p53 levels. 23758631
EL1182 SENCR RNA-seq, RT-PCR and rapid amplification of cDNA, Western blotting, Loss-of-function studies human coronary artery smooth muscle cells N/A N/A SENCR is a new vascular cell-enriched, cytoplasmic lncRNA that seems to stabilize the smooth muscle cell contractile phenotype. 24578380
EL1184 SFTA3 N/A lung and foregut endoderm N/A interaction LL18/NANCI acts upstream of Nkx2.1 and downstream from Wnt signaling to regulate lung endoderm gene expression. 24939938
EL1186 Sho RT-PCR roots and young leaves up-regulated N/A Sho is a natural antisense transcript. Sho may function in roots and young leaves, involve the production of small RNAs. In addition to cytokinin transport and inactivation, antisense transcription can be activated in a tissue-specific manner to adjust local cytokinin synthesis via degradation of Sho dsRNA. We therefore propose that, in addition to cytokinin transport and inactivation, regulation of local cytokinin synthesis via antisense transcription represents yet another device for the complex control of local cytokinin levels in plants. 17944812 PLNlncRbase
EL1187 Si lincRNA113 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1188 Si lincRNA121 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1189 Si lincRNA150 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1190 Si lincRNA18 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1191 Si lincRNA180 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1192 Si lincRNA212 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1193 Si lincRNA248 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1194 Si lincRNA288 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1195 Si lincRNA32 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1196 Si lincRNA373 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1197 Si lincRNA396 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1198 Si lincRNA403 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1199 Si lincRNA416 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1200 Si lincRNA438 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1201 Si lincRNA446 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1202 Si lincRNA489 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1203 Si lincRNA69 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1204 Si NAT52 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1205 Si NAT80 qRT-PCR drought N/A N/A Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress (Table S12) 23860794 PLNlncRbase
EL1206 SIRT1-AS sequencing and bioinformatic analysis C2C12 cells up-regulated N/A The expression of both Sirt1 mRNA and Sirt1 AS lncRNA decreased during C2C12 myogenic differentiation, whereas the levels of miR-34a, which targets Sirt1, increased gradually. overexpression of Sirt1 AS lncRNA mutant did not affect the level of Sirt1 protein in C2C12 cells. Moreover, downregulation of Sirt1 mRNA caused by miR-34a was counteracted by Sirt1 AS lncRNA in C2C12 cells. 24480449
EL1208 Six3os1 RNA-seq, RNA CaptureSeq, and ChIP-seq adult mouse subventricular zone neural stem cell lineage N/A expression shRNA-mediated knockdown of two such lncRNAs, Six3os and Dlx1as, indicate roles for lncRNAs in the glial-neuronal lineage specification of multipotent adult stem cells. 23583100
EL1208 Six3os1 SAGE, in situ hybridization developing retina N/A expression Multiple transcripts that were evolutionarily conserved that did not appear to encode open reading frames of more than 100 amino acids in length ("noncoding rnas") were found to be dynamically and specifically expressed in developing and mature retinal cell types. 15226823
EL1217 sme2 N/A N/A N/A interaction Meirna targets mei2 to the nucleus, where it can promote the first meiotic division. 10021358
EL1217 sme2 N/A N/A N/A interaction This rna is likely to facilitate the assembly of mei2p into a dot structure and trap the protein as such in the nucleus. 11423126
EL1217 sme2 N/A N/A N/A interaction Mei2p dot is a specialized structure, either to foster the assembly of mei2p and meirna or to perform some unidentified function indispensable for meiosis i. 12808043
EL1217 sme2 N/A N/A N/A expression Cells without meirna perform premeiotic dna synthesis but cannot undergo meiosis i. 7520368
EL1217 sme2 N/A Fission yeast N/A interaction Meirna contributes to the promotion of meiosis i exclusively as a cofactor that assists nuclear transport of mei2p. 9778252
EL1221 SNHG1 N/A N/A N/A expression The spliced uhg rna, although it is associated with polysomes, has little potential for protein coding, is short-lived, and is poorly conserved between human and mouse. 8559254
EL1221 SNHG1 N/A HeLa cells N/A expression Comparison of the human and mouse u17hg genes has revealed that snorna-encoding intron sequences but not exon sequences are conserved between the two species and that neither human nor mouse spliced u17hg poly(a)+ rnas have the potential to code for proteins. 9671460
EL1229 Snhg3 knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Involved in maintaining pluripotency in ESCs. 21874018
EL1232 SNHG6 N/A N/A N/A expression U87hg rna shows a relatively high degree of conservation suggesting a selective pressure and a possible functional activity of u87hg apart from producing u87 snorna. 16226852
EL1236 SOX2-OT real-time polymerase chain reaction (RT-PCR) NT-2 pluripotent cell line down-regulated N/A the down-regulation of SOX2OT and SOX2 genes by an miRNA 26862518
EL1236 SOX2-OT real-time RT-PCR five human cancer cell lines N/A mutation SOX2OT-7 is almost the most abundant form of SOX2OT transcript variants in the examined cancer cell lines particularly in NT2 teratocarcinoma cell line where its expression falls upon neuronal-like differentiation similar to SOX2 and OCT4A. 26703382
EL1236 SOX2-OT real-time RT-PCR five human cancer cell lines N/A mutation N/A 26703382
EL1236 SOX2-OT TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression The lncRNA MALAT1 and SOX2OT were induced in both TK6 and WTK1 cells 23698766
EL1240 SPRY4-IT1 N/A N/A down-regulated interaction The lncRNA SPRY4-IT1 regulates the intestinal epithelial barrier function by altering expression of tight junction (TJ) proteins. SPRY4-IT1 silencing led to dysfunction of the epithelial barrier in cultured cells by decreasing the stability of mRNAs encoding TJ proteins claudin-1, claudin-3, occludin, and JAM-1 and repressing their translation. In contrast, increasing the levels of SPRY4-IT1 in the intestinal mucosa protected the gut barrier in mice exposed to septic stress by increasing the abundance of TJ proteins. 26678886
EL1241 SRA1 N/A N/A N/A interaction SRA is important for maintaining the stem cell state and for reprogramming of human fibroblasts to achieve the pluripotent state. 26496121
EL1241 SRA1 N/A N/A N/A epigenetics Mpus1p-dependent pseudouridylation of sra represents an additional type of posttranscriptional modification of a nr-coactivator complex that is important for nr signaling. 15327771
EL1241 SRA1 overexpression a transgenic-mouse model, transgenic mammary glands N/A expression Although coactivation of steroid-dependent transcription by sra is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis. 14517287
EL1241 SRA1 TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression SRA1 was induced in TK6 cells only. 23698766
EL1241 SRA1 transfected SRA, Biochemical fractionation N/A N/A expression Sra may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation. 10199399
EL1242 SrENOD40-1 RT-PCR Nodule formation down-regulated N/A By reverse transcriptase PCR, enhanced SrENOD40-1 expression was observed in the adventitious root primordia between 4 and 8 h after inoculation with Azorhizobium caulinodans. SrENOD40-1 expression with highest levels in middle and inner cortical cells. SrENOD40-1 was expressed in these primordia and in parenchymatous cells surrounding the developing connecting vascular bundles. SrENOD40-1 transcripts were still most prominent around the nodule vascular bundles. In the root, expression was detected around the vascular bundle of lateral root primordia and of the younger parts of the main root. SrENOD40-1 expression was seen, both in longitudinal and in transverse sections. 9620265 PLNlncRbase
EL1243 SRG1 N/A N/A N/A interaction Expression of the srg1 rna is required for repression of ser3. 15175754
EL1243 SRG1 N/A N/A N/A interaction Intergenic transcription allows activators to act indirectly as repressors. 16291644
EL1244 SRP RNA N/A N/A N/A interaction Reconstitutions with heterologous components revealed a significant potential of human srp proteins to bind to archaeal srp rnas. m.jannaschii srp rna bound to human srp54m quantitatively in the absence of srp19. 10684931
EL1251 TalIPS1 qRT–PCR phosphate balance up-regulated N/A The expression patterns of other members of the TPSI1/Mt4 family in monocots were also investigated. The induced expressions of OsIPS1, HvIPS1, ZmIPS2 and TalIPS2 were stronger than those of OsIPS2, HvIPS2 ZmIPS1 and TalIPS1 in roots after 4 or 10 d of Pi starvation, whereas higher induced expressions of OsIPS2, HvIPS1, ZmIPS1 and TalIPS1 were detected in shoots. 10.1111/j.1365-3040.2005.01272.x PLNlncRbase
EL1252 TalncRNA106 RT-PCR stripe rust pathogen up-regulated N/A TalncRNA106 were located to wheat chromosome 5B. appeared higher level of expression in resistance genotypes. lncRNA106 could be detected in single-resistance genotype. For TalncRNA18 and TalncRNA106, there appeared higher level of expression in resistance genotypes than that in susceptible genotype at all time points, especially at 2 and 7 days post-infection,That suggests that the fluctuation maybe one primary characterization of long non-protein-coding RNA other than the induction expression. May play a crucial role in assisting the plant defence against pathogen attack in wheat. 24065539 PLNlncRbase
EL1253 TalncRNA108 RT-PCR stripe rust pathogen down-regulated N/A TalncRNA108 is a homolog to RRNA intron-encoded homing endonuclease(XP003614385.1) and an uncharacterized protein (XP003541241.1) from Medicago truncatula and Glycine max,respectively,the TalncRNA18 consists of 1,393 nt,was located to wheat chromosome 7A and the short arm of chromosome 4B. And played some roles in the proceeding of defense on stripe rust(caused by Puccinia striiformis f.sp.tritici (Pst)) in wheat though RNAi. 24065539 PLNlncRbase
EL1254 TalncRNA18 RT-PCR stripe rust pathogen up-regulated N/A TalncRNA18 is a partial cDNA of E3 ubiquitin-protein ligase UPL1-like gene. TalncRNA18 contains of six snRNP motifs at the position of 125, 361, 498, 920, 1,107 and 1,331 nt,was located to chromosome 5B. Following inoculation with Pst CYR 32, lncRNA18 transcripts were up-regulated rapidly at 1 dpi in the double-resistance genotype (YrSM139-1B+YrSM139-2D) plant-pathogen incompatible interaction and followed by a stable expression level. Based on statistical analyses, TalncRNA18 expression is significantly higher than that in susceptible line at 0 dpi. Although the expression decreased after 2 dpi, the accumulations of TalncRNA18 are higher than that in single-resistance genotype plant-pathogen incompatible interactions and compatible interactions except 7dpi. And played some roles in the proceeding of defense on stripe rust(caused by Puccinia striiformis f.sp.tritici (Pst)) in wheat though RNAi. 24065539 PLNlncRbase
EL1255 TalncRNA73 RT-PCR stripe rust pathogen up-regulated N/A TalncRNA73 is an antisense transcript of hypothetical protein,were located to wheat chromosome 7A and the short arm of chromosome 4B. TalncRNA73, a non-proteincoding gene is a natural antisense transcript from a hypothetical protein of S.bicolorand induced by inoculation with stripe rust (caused by Puccinia striiformis f.sp.tritici (Pst)) in wheat. The expression level of TalncRNA73 in double resistance genotype increased rapidly at 1 dpi and reached a peak at 3 dpi, and then decreased to the bottom at 4 dpi, followed by a steeply rise to another peak at 7 dpi and decline again at 10 dpi. The current work suggested that a possible role for TalncRNA73 is to modulate protein-coding gene that trigger a defense response in resistant plants. 24065539 PLNlncRbase
EL1256 TapmlnRNA19 Microarray/qRT-PCR powdery mildew infection up-regulated N/A TapmlnRNA19 was up-regulated after powdery mildew inoculation, and responsive to powdery mildew infection. TapmlnRNA19 was the precursors of miR2004. TapmlnRNA19 accumulated preferentially in young spike. 21473757 PLNlncRbase
EL1257 TapmlnRNA27 Microarray/qRT-PCR seeds N/A N/A A total of 48 putative long npcRNAs were only responsive to powdery mildew infection (designated TapmlnRNA), see details in additional file 1. 21473757 PLNlncRbase
EL1258 TapmlnRNA30 Microarray/qRT-PCR seeds up-regulated N/A TapmlnRNA30 was up-regulated after powdery mildew inoculation. TapmlnRNA30 was only detected in seed. 21473757 PLNlncRbase
EL1259 TapmlnRNA5 Microarray/qRT-PCR seeds N/A N/A A total of 48 putative long npcRNAs were only responsive to powdery mildew infection (designated TapmlnRNA), see details in additional file 1. 21473757 PLNlncRbase
EL1260 TapmlnRNA9 Microarray/qRT-PCR young spikes N/A N/A A total of 48 putative long npcRNAs were only responsive to powdery mildew infection (designated TapmlnRNA), see details in additional file 1. 21473757 PLNlncRbase
EL1261 TAR-191 RNA-seq/qRT-PCR disease development up-regulated N/A TAR-191, a spliced lincRNA located in the intergenic region (c.1.3kb) between At2g25295 and At2g25300, was confirmed by qRT-PCR to be highly induced by Fusarium oxysporum infection. 24117540 PLNlncRbase
EL1262 TAR-224 RNA-seq/qRT-PCR disease development down-regulated N/A TAR-224 was found c.550-bp downstream of At2g44745. Both TAR-224 and At2g44745 were induced upon Fusarium oxysporum infection but a much higher induction was observed for TAR-224. The expression level of TAR-224 was significantly knocked down in its RNAi plants.but an induction of TAR-224 was not abolished in F6DPI even though the level of induction was c.10-fold lower than that observed in Col-0 Nevertheless, the reduction was enough to enhance disease development. 24117540 PLNlncRbase
EL1264 TaS1 RT-PCR leaves up-regulated N/A TaS1 was specifically expressed in leaves and hardly detectable in roots. TaS1 could promote host susceptibility which contributed to the pathogen infection. TaS1 were expressed only in susceptible hosts and up-regulated during the phase of the primary fungus infection and haustorial development.the suppression of TaS1 and enhanced wheat resistance susceptibility to powdery mildew. 10.1007/s10535-014-0404-y PLNlncRbase
EL1265 TaS2 RT-PCR roots up-regulated N/A TaS2 was detected in almost all of the three organs, but preferentially expressed in roots. TaS2 could promote host susceptibility which contributed to the pathogen infection. TaS2 were expressed only in susceptible hosts and up-regulated during the phase of the primary fungus infection and haustorial development.the suppression of TaS2 enhanced wheat resistance susceptibility to powdery mildew. 10.1007/s10535-014-0404-y PLNlncRbase
EL1272 TCONS_00000649 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00000649 was obviously up-regulated in stressed leaves, exhibited leaf-specific expression as determined by qRT-PCR. 24892290 PLNlncRbase
EL1274 TCONS_00007700 qRT-PCR/RNA-seq drought down-regulated/up-regulated N/A TCONS_00007700 was obviously up-regulated in stressed leaves. TCONS_00007700, which was up-regulated in stressed leaves, was down-regulated in stressed roots as determined by qRT-PCR. 24892290 PLNlncRbase
EL1275 TCONS_00010027 RT-PCR/RNA-seq roots N/A N/A TCONS_00010027 is identified a pre-lncRNA,This pre-lncRNA (TCONS_00010027 ) has se-quence similarity with small RNAs and thus may be chopped into pieces and function as a small RNA. 24576388 PLNlncRbase
EL1277 TCONS_00012662 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00012662 is precursor sequences of MIR167j, TCONS_00012662 was intergenic lncRNAs, showed up-regulation in drought-stress leaves in comparison with RNA-seq. 24892290 PLNlncRbase
EL1278 TCONS_00012690 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00012690 was obviously up-regulated in stressed leaves as determined by qRT-PCR. 24892290 PLNlncRbase
EL1279 TCONS_00012703 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00012703 is homologous to multiple siRNA reads. In addition, the RT-qPCR result of TCONS_00012703 RNA demonstrates that the expression level of the lncRNAs is relatively low in both non-stressed leaves and roots but accumulates to high levels after drought stress in both plant tissues. 24892290 PLNlncRbase
EL1280 TCONS_00012768 qRT-PCR/RNA-seq drought down-regulated N/A TCONS_00012768 was down-regulated in drought-stressed roots as determined by qRT-PCR. 24892290 PLNlncRbase
EL1284 TCONS_00022311 RNA-seq/qRT-PCR wood formation up-regulated N/A In our study, TCONS_00022311 was predicted to target a GA2ox, suggesting that lncRNAs may take part in regulating wood for mation through gibberellin biosynthesis. 25230698 PLNlncRbase
EL1285 TCONS_00023843 RNA-seq/qRT-PCR wood formation up-regulated N/A We also checked the sequences for lncRNAs that correspond to miRNA precursors, and found that only three of the 1377 lncRNAs (0.2 %), i.e., TCONS_00061773,TCONS_00023843 and TCONS_00048079, harbor complete precursors, for four miRNAs (Ptc-miR1448, Ptc-miR482a.2, Ptu-172 and Ptu-37) (Table 4; Fig. 7). 25230698 PLNlncRbase
EL1286 TCONS_00024309 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00024309 is precursor sequences of MIR399e, TCONS_00024309 was intergenic lncRNAs, exhibited up-regulation in drought-stressed leaves as determined by qRT-PCR but showed down-regulation in comparison with RNA-seq. 24892290 PLNlncRbase
EL1287 TCONS_00024310 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00024310 is precursor sequences of MIR399e, TCONS_00024310 was intergenic lncRNAs, exhibited up-regulation in drought-stressed leaves as determined by qRT-PCR but showed down-regulation in comparison with RNA-seq. 24892290 PLNlncRbase
EL1290 TCONS_00026694 RNA-seq/qRT-PCR wood formation down-regulated N/A The expression of type A and B lncRNAs such as TCONS_00026694 and TCONS_00028236 was NW>TW>OW and NW>OW>TW, and these lncRNAs were similarly suppressed by tension and compression stresses (Supplementary material S6). 25230698 PLNlncRbase
EL1291 TCONS_00028236 RNA-seq/qRT-PCR wood formation down-regulated N/A The expression of type A and B lncRNAs such as TCONS_00026694 and TCONS_00028236 was NW>TW>OW and NW>OW>TW, and these lncRNAs were similarly suppressed by tension and compression stresses (Supplementary material S6). 25230698 PLNlncRbase
EL1292 TCONS_00032782 RNA-seq/qRT-PCR wood formation up-regulated N/A In our study, TCONS_00032782, which was predicted to target Pt-CSLD4, revealed that lncRNA might function in wood formation through regulation of CSLD in Populus. 25230698 PLNlncRbase
EL1293 TCONS_00037470 qRT-PCR/RNA-seq drought down-regulated/up-regulated N/A TCONS_00037470 was down-regulated in drought-stressed roots as determined by qRT-PCR. And this lncRNA was upregulated in drought-stress leaves(see Table S2 for details). 24892290 PLNlncRbase
EL1295 TCONS_00042984 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00042984 is precursor sequences of MIR169h, TCONS_00042984 was intergenic lncRNAs, showed up-regulation in drought-stress leaves in comparison with RNA-seq. 24892290 PLNlncRbase
EL1296 TCONS_00044116 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00044116 is precursor sequences of MIR399b, TCONS_00044116 was intergenic lncRNAs, exhibited up-regulation in drought-stressed leaves as determined by qRT-PCR but showed down-regulation in comparison with RNA-seq. 24892290 PLNlncRbase
EL1297 TCONS_00044376 RNA-seq/qRT-PCR wood formation down-regulated N/A The lncRNAs showing lowest expression in NW belonged to type C (TW>OW>NW) and D (OW>TW>NW), and included TCONS_00044376 and TCONS_00055243 (Supplementary material S6). 25230698 PLNlncRbase
EL1298 TCONS_00048079 RNA-seq/qRT-PCR wood formation up-regulated N/A We also checked the sequences for lncRNAs that correspond to miRNA precursors, and found that only three of the 1377 lncRNAs (0.2 %), i.e., TCONS_00061773,TCONS_00023843 and TCONS_00048079, harbor complete precursors, for four miRNAs (Ptc-miR1448, Ptc-miR482a.2, Ptu-172 and Ptu-37) (Table 4; Fig. 7). 25230698 PLNlncRbase
EL1300 TCONS_00053930 RNA-seq/qRT-PCR wood formation up-regulated N/A Another target gene( POPTR_0001s07400.1), predicted to be targeted by TCONS_00053930, encodes a protein similar to 4CL, the central enzyme of the plant-specific phenylpropanoid pathway, which has an important role in lignin biosynthesis (Table 3). 25230698 PLNlncRbase
EL1301 TCONS_00054544 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00054544 is precursor sequences of MIR827, TCONS_00054544 was an overlapping lncRNAs, exhibited up-regulation in drought-stressed leaves as determined by qRT-PCR but showed down-regulation in comparison with RNA-seq. 24892290 PLNlncRbase
EL1302 TCONS_00055243 RNA-seq/qRT-PCR wood formation down-regulated N/A The lncRNAs showing lowest expression in NW belonged to type C (TW>OW>NW) and D (OW>TW>NW), and included TCONS_00044376 and TCONS_00055243 (Supplementary material S6). 25230698 PLNlncRbase
EL1303 TCONS_00056386 RNA-seq/qRT-PCR wood formation up-regulated N/A Genes encoding glucosyltransferases were predicted as targets of TCONS_00056386 (Table 3; Fig. 3b). Besides the genes related to cellulose, lignin and glucosyltransferase, POPTR_0010s15950.1 (Pt-GA2.3) encodes GA2ox and was predicted as a target of TCONS_00022311 (Fig. 3c). TCONS_00056386) was detected as having its highest expression in OW, then TW and lowest in NW (Supplementary material S5) by RNA-seq and a similar expression pattern was also detected by qRT-PCR. 25230698 PLNlncRbase
EL1304 TCONS_00056395 qRT-PCR/RNA-seq drought down-regulated N/A A root-specific lncRNA of TCONS_00056395, down regulation in stressed leaves and exhibit maximum expression in leaves stressed for 5h as determined by qRT-PCR. 24892290 PLNlncRbase
EL1305 TCONS_00060049 RNA-seq/qRT-PCR wood formation up-regulated N/A Although CCOMTs play important roles in lignin content, little is known about the regulators of CCOMT. TCONS_00060049 was predicted to target CCOMT, suggesting that it may have a potential role in lignin formation by regulation of CCOMT (Table 3). 25230698 PLNlncRbase
EL1306 TCONS_00061773 RNA-seq/qRT-PCR wood formation up-regulated N/A TCONS_00061773 harbors precursors for two known miRNAs, Ptc-miR1448 and Ptc-miR482a.2 (Fig. 7). Previous studies supported the idea that Ptc-miR1448 may be involved in the resistance of plants to biotic and abiotic stresses (Lu et al. 2008) and Ptc-miR482a.2 has been reported as a tree-specific miRNA in tension wood (Lu et al. 2005, 2008). The expression measured by qRT-PCR revealed that Ptc-miR1448 is much more abundant than Ptc-miR482a.2, although both miRNAs occur in one cluster in the genome (Lu et al. 2005, 2008). These findings supported the idea that TCONS_00061773 may be associated with abiotic stress tolerance in Populus. 25230698 PLNlncRbase
EL1307 TCONS_00082174 qRT-PCR/RNA-seq drought up-regulated N/A TCONS_00082174, which was only expressed in leaves, was not detected in roots, which suggests leaf-specific expression as determined by qRT-PCR. 24892290 PLNlncRbase
EL1308 TCONS_00089485 RT-PCR/RNA-seq embryo sac and ovule tissues N/A N/A TCONS_00089485 is expressed from the Vgt1 regulatory region. This lncRNA is detected in embryo sac and ovule tissues where ZmRap2 is not detected. while ZmRap2 is expressed in other tissues where this HC-lncRNA is not detected, Suggesting the potential for antagonistic expression of this HC-lncRNA and the nearby coding sequence. 24576388 PLNlncRbase
EL1322 TER N/A Arabidopsis thaliana N/A interaction TER works in concert with the telomerase reverse transcriptase (TERT) to maintain telomeres. 26442096
EL1323 TER1 RT-PCR DNA damage down-regulated N/A As the essential RNA subunit of telomerase, TER1 is required for telomere maintenance, while TER2 is assembled in distinct RNP complex (es)to modulate telomerase activity in response to DNA damage. (Wang et al., 2014) TER1 and TER2 copurify with telomerase activity and serve as templates for telomerase in vitro, depletion of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening in vivo. Moreover, mutation of the templating domain in TER1 results in the incorporation of mutant telomere repeats on chromosome ends. Thus, TER1 provides the major template for telomerase in vivo. Both TER1 and TER2 function as templates for TERT in vitro, but only TER1 plays a significant role in telomere maintenance in vivo. Moreover, we show that TER1, but not TER2, specifically binds POT1a in vitro and the two components assemble into an enzymatically active RNP in vivo. These findings underscore the evolution of telomerase and telomere proteins in Arabidopsis and argue that the process is driven by gene duplication. (Cifuentes-Rojas et al., 2011) 24398630, 21164032 PLNlncRbase
EL1324 TER2 RT-PCR telomere shortening down-regulated N/A We show that TER2 is spliced and its 3' end is truncated in vivo to generate a third TER isoform, TER2S. Plants null for TER2 display increased telomerase enzyme activity, while TER2 overexpression inhibits telomere synthesis from TER1 and leads to telomere shortening. These findings argue that TER2 negatively regulates telomerase by sequestering TERT in a nonproductive RNP complex. Introduction of DNA double-strand breaks by zeocin leads to an immediate and specific spike in TER2 and a concomitant decrease in telomerase enzyme activity. This response is not triggered by replication stress or telomere dysfunction and is abrogated in ter2 mutants. We conclude that Arabidopsis telomerase is modulated by TER2, a novel DNA damage induced noncoding RNA that works in concert with the canonical TER to promote genome integrity. (Cifuentes-Rojas et al., 2012) TER2 (GenBank accession no. HQ401285), was also uncovered. TER2 maps to chromosome 5, in the opposite direction and partially overlapping with the 5′ UTR of another unknown protein coding gene, AT5G24670. TER2 also contains 1.5 copies of the Arabidopsis telomere repeat. RT-PCR confirmed that both TER1 and TER2 RNAs were enriched in purified telomerase fractions, in contrast to a U6 snRNA control. (Cifuentes-Rojas et al., 2011) As the essential RNA subunit of telomerase, TER1 is required for telomere maintenance, while TER2 is assembled in distinct RNP complex (es)to modulate telomerase activity in response to DNA damage. (Wang et al., 2014) 23109676, 21164032, 24398630 PLNlncRbase
EL1326 TGFB2-OT1 microarray, RNA interference, RNA-chiP assay, bioinformatics, luciferase reporter assay N/A N/A interaction The protein level of MAP1LC3B-II was greatly increased in HUVECs with FLJ11812 overexpression.FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 25437332
EL1326 TGFB2-OT1 miRNA chip assay, overexpression, 3BDO vascular endothelial cells (VECs) N/A interaction TGFB2-OT1 regulated the levels of 3 microRNAs, MIR3960, MIR4488 and MIR4459. TGFB2-OT1 acted as a competing endogenous RNA, bound to MIR3960, MIR4488 and MIR4459, then regulated the expression of the miRNA targets CERS1 (ceramide synthase 1), NAT8L (N-acetyltransferase 8-like [GCN5-related, putative]), and LARP1 (La ribonucleoprotein domain family, member 1). TGFB2-OT1 increased the LARP1 level, which promoted SQSTM1 (sequestosome 1) expression, NFKB RELA and CASP1 activation, and then production of IL6, IL8 and IL1B in VECs. 26565952
EL1327 TH2LCRR N/A human T-cell cultures N/A expression One lncRNA cluster selectively expressed by the effector TH2 lineage consists of four alternatively spliced transcripts that regulate the expression of TH2 cytokines, IL-4, IL-5 and IL-13.Genes encoding this lncRNA cluster in humans overlap the RAD50 gene and thus are contiguous with the previously described TH2 locus control region (LCR) in the mouse. Given its genomic synteny with the TH2-LCR, we refer to this lncRNA cluster as TH2-LCR lncRNA. 25903499
EL1337 TIP ncRNA Profiling murine in vitro neural differentiation system N/A N/A TIP transcription may ensure coordinated regulation of gene networks via dynamic switching and recruitment of PcG proteins both in cis and in trans during lineage commitment. 22336714
EL1344 Tmevp3 Quantitative RT-PCR, chromatin immunoprecipitation N/A up-regulated interaction This lncRNA regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFN-γ, and susceptibility to a viral and a bacterial pathogen. 23415224
EL1345 Tmevpg1 N/A N/A N/A N/A The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mrna. 11735227
EL1348 Tog qRT-PCR, ChIP on chip cecal buds N/A interaction N/A 24075990
EL1352 TPS1 Northern blot/qRT-PCR roots up-regulated N/A INDUCED BY PHOSPHATE STARVATION1 is a member of the TPS1/Mt4 gene family that acts as a miR399 target mimic in fine tuning of PHO2 (encoding an E2 ubiquintin conjugase-related enzyme)expression and phosphate uptake in Arabidopsis, tomato and Medicago truncatula but does not encode a protein. 24576388 PLNlncRbase
EL1353 TPS11 Northern blot/Southern blot roots up-regulated N/A This lncRNAs work as a decoy of miRNAs,and exert their functions by binding miRNAs in a target mimicry mechanism to sequestrate the miRNAs’ regulation roles on their target genes, such as lncRNAs IPS1 and at4. 23726911 PLNlncRbase
EL1354 TPSI1 Northern blot/Southern blot roots up-regulated N/A The TPSI1 transcripts are rapidly induced in roots and leaves during Pi starvation. Induction of the TPSI1 gene appears to be a response specific to Pi starvation since it is not affected by starvation of other nutrients (nitrogen, potassium and iron). The amount of TPSI1 transcript decreased rapidly when Pi-starved tomato plants were resupplied with Pi. These results suggest that TPSI1 gene expression may be a part of the early Pi starvation response mechanism in plants. 9106510 PLNlncRbase
EL1359 Trenod40 Northern blot/Southern blot nodule development up-regulated N/A Enod40 is one of the genes associated with legume nodule development and has a putative role in general plant organogenesis. In situ hybridization studies revealed that Trenod40 genes were highly expressed in non-symbiotic tissues, particularly in stolon nodes during nodal root and lateral shoot development. High levels of Trenod40 transcripts were also present in the vascular bundles of mature plant organs, mainly at sites of intensive lateral transport, suggesting a role in vascular tissue function. The expression pattern of Trenod40 genes was analyzed further using Trenod40 promoter-gus fusions in transgenic white clover and tobacco (Nicotiana tabacum), indicating that white clover and tobacco share the regulatory mechanisms for Trenod40-1/2 promoters and some aspects of Trenod40-3 regulation. Trenod40 expression occurs in the xylem parenchyma of vascular bundles in white clover nodes that conjoin both young and fully developed leaves provide support for a role in vascular tissue function. 12114565 PLNlncRbase
EL1360 Trenod40-1 Northern blot/Southern blot nodule development up-regulated N/A Enod40 is one of the genes associated with legume nodule development and has a putative role in general plant organogenesis. We have isolated a small enod40 gene family from white clover (Trifolium repens), with three genes designated Trenod40-1, Trenod40-2, and Trenod40-3, all containing the conserved enod40 regions I and II. Trenod40-1 and Trenod40-2 share over 90% homology in the transcribed regions and high levels of similarity in their upstream regulatory sequences. Trenod40-1 and Trenod40-2 are similar to the enod40 genes of legumes forming indeterminate nodules (group II) and are predominantly expressed in nodules. 12114565 PLNlncRbase
EL1361 Trenod40-2 Northern blot/Southern blot nodule development up-regulated N/A Enod40 is one of the genes associated with legume nodule development and has a putative role in general plant organogenesis. We have isolated a small enod40 gene family from white clover (Trifolium repens), with three genes designated Trenod40-1, Trenod40-2, and Trenod40-3, all containing the conserved enod40 regions I and II. Trenod40-1 and Trenod40-2 share over 90% homology in the transcribed regions and high levels of similarity in their upstream regulatory sequences. Trenod40-1 and Trenod40-2 are similar to the enod40 genes of legumes forming indeterminate nodules (group II) and are predominantly expressed in nodules. 12114565 PLNlncRbase
EL1362 Trenod40-3 Northern blot/Southern blot nodule development up-regulated N/A The developing lateral shoot of node N7 also has up-regulation of Trenod40-1/2 expression, which is confined to the vascular tissue at the base of the lateral shoot (Fig. 5E). Trenod40-3 was also expressed in developing lateral shoots, with high levels of expression localized mainly in the vascular tissue but also in other tissues of both the axillary bud of node N6 (Fig. 5F) and more mature lateral shoot of node N8 (Fig. 5G). Trenod40-3 transcript is only present at relatively low levels in nodules, but is abundant in some non-symbiotic tissues. Expression of Trenod40-3 being more prominent and induced both at early and later stages of lateral shoot development. 12114565 PLNlncRbase
EL1365 Trp53cor1 N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
EL1369 Tsix N/A mouse embryonic epiblasts, epiblast stem cells, and embryonic stem cells N/A mutation Tsix RNA is believed to orchestrate the initiation of X-inactivation, influencing the choice of which X remains active by preventing expression of the antisense Xist RNA, which is required to silence the inactive-X. 25981039
EL1372 Ttc39aos1 Inhibition, ectopic expression mouse erythroid cells down-regulated N/A Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation . anti-apoptosis and promote erythoid differentiation 22155924
EL1373 tts-1 N/A normal strains of Caenorhabditis elegans and those carrying the life-extending daf-2 mutation N/A expression The expression of tts-1 functions in different longevity pathways to reduce ribosome levels in a way that promotes life extension 25600869
EL1374 TU1273 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1375 TU1378 RNA-seq, qRT-PCR mycelia stage up-regulated N/A The expression profiles of 5 lincRNAs were negatively correlated with those of their apcGenes (Figure 5B,r<-0.8). The apcGenes of TU718, TU1378, TU3327, and TU5007 are a putative hydrolase (GL15069), a Barwin-related endoglucanase (GL18494), a putative hydrolase (GL27846), and an alphaamylase (GL24914), respectively, which all belong to CAZy family. 24932683 PLNlncRbase
EL1376 TU1403 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1377 TU1555 RNA-seq, qRT-PCR mycelia stage up-regulated N/A The log ratios for the expression levels of lincRNAs to apcGenes were shown in Figure 4. The expression of three lincRNAs (TU1378, TU1555, and TU4508) and an apcGene (GL27157) were detected only in the mycelia stage, whereas the expression of TU3327 was detected in mycelia and primordia stages. 24932683 PLNlncRbase
EL1378 TU1567 RNA-seq, qRT-PCR mycelia, primordia, stage up-regulated N/A For the other three lincRNAs located at the 5' end of their apcGenes, TU1567 was adjacent to a pheromone B alpha 3 receptor gene. TU1567 was expressed bidirectionally only in the mycelia, consistent with its possible involvement in the mating process. 24932683 PLNlncRbase
EL1379 TU1970 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of five lincRNAs/apcGenes pairs exhibited significantly negative correlations (Figure 5B). In this group, four of five lincRNAs located in the 5' region of their apcGenes (Figure 3A and 3B), in which three (TU1970, TU3327, and TU5007) were transcribed in the opposite direction. TU718 was transcribed in the same direction. The other lincRNA (TU1378) located in the 3' region of its apcGenes and was transcribed in the same direction (Figure 3A and 3B). (see in the section "Potential roles of lincRNAs whose expression are significantly correlated with those of apcGenes"for details) 24932683 PLNlncRbase
EL1380 TU3327 RNA-seq, qRT-PCR mycelia and primordia stages up-regulated N/A The expression profiles of 5 lincRNAs were negatively correlated with those of their apcGenes (Figure 5B,r<-0.8). The apcGenes of TU718, TU1378, TU3327, and TU5007 are a putative hydrolase (GL15069), a Barwin-related endoglucanase (GL18494), a putative hydrolase (GL27846), and an alphaamylase (GL24914), respectively, which all belong to CAZy family. 24932683 PLNlncRbase
EL1381 TU3423 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A For the other three lincRNAs located at the 5' end of their apcGenes, TU1567 was adjacent to a pheromone B alpha 3 receptor gene. TU1567 was expressed bidirectionally only in the mycelia, consistent with its possible involvement in the mating process (Figure 3C, Table S4). Two bidirectional lincRNAs (TU532 and TU3423) were adjacent to the CAZy family genes and showed developmentally preferential expression among the three stages (Figure 3C, Table S4). TU532 was expressed bidirectionally in the primordia and expressed in the reverse direction in the mycelia or fruiting bodies (Figure 3C, Table S4). For TU3423, bidirectional transcription was not detected in the fruiting bodies. These two lincRNAs may be involved in carbohydrate metabolism as indicated by their expression profiles. 24932683 PLNlncRbase
EL1382 TU4313 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A TU4313 was adjacent to the gene GL24088, encoding a hydrox ymethylglutaryl-CoA reductase (HMGR). HMGR is involved in isopentenyl diphosphate production in the MVA pathway, which is the crucial precursor of triterpenoids. Also showed distinct expression profiles. As HMGR is a rate-limiting enzyme in the MVA pathway, the presence of these three lincRNAs with distinct expression profiles may reflect a novel regulatory mechanism of the MVA pathway. 24932683 PLNlncRbase
EL1383 TU4314 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A TU4314 was adjacent to the gene GL24088, encoding a hydroxy methylglutaryl-CoA reductase (HMGR). HMGR is involved in isopentenyl diphosphate production in the MVA pathway, which is the crucial precursor of triterpenoids. Also showed distinct expression profiles. As HMGR is a rate-limiting enzyme in the MVA pathway, the presence of these three lincRNAs with distinct expression profiles may reflect a novel regulatory mechanism of the MVA pathway. 24932683 PLNlncRbase
EL1384 TU4508 RNA-seq, qRT-PCR mycelia stage up-regulated N/A The log ratios for the expression levels of lincRNAs to apcGenes were shown in Figure 4. The expression of three lincRNAs (TU1378, TU1555, and TU4508) and an apcGene (GL27157) were detected only in the mycelia stage, whereas the expression of TU3327 was detected in mycelia and primordia stages. 24932683 PLNlncRbase
EL1385 TU4652 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. The apcGenes of TU4652 and TU781 are a laccase 3 (GL29234) and a glyoxal oxidase precursor (GL20538), respectively, which belong to the lignin degradation pathway. 24932683 PLNlncRbase
EL1386 TU4684 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. The apcGenes of TU4652 and TU781 are a laccase 3 (GL29234) and a glyoxal oxidase precursor (GL20538), respectively, which belong to the lignin degradation pathway. In contrast, The apcGenes of TU51, TU4779, and TU4684 are an alpha-glucosidase (GL30020), a putative hydrolase (GL19744), a chitinase 1 (GL24376), respectively, all of which belong to CAZy family. 24932683 PLNlncRbase
EL1387 TU4779 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. The apcGenes of TU4652 and TU781 are a laccase 3 (GL29234) and a glyoxal oxidase precursor (GL20538), respectively, which belong to the lignin degradation pathway. In contrast, The apcGenes of TU51, TU4779, and TU4684 are an alpha-glucosidase (GL30020), a putative hydrolase (GL19744), a chitinase 1 (GL24376), respectively, all of which belong to CAZy family. 24932683 PLNlncRbase
EL1388 TU5007 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A On the other hand, the expression profiles of 5 lincRNAs were negatively correlated with those of their apcGenes (Figure 5B,r<-0.8). The apcGenes of TU718, TU1378, TU3327, and TU5007 are a putative hydrolase (GL15069), a Barwin-related endoglucanase (GL18494), a putative hydrolase (GL27846), and an alphaamylase (GL24914), respectively, which all belong to CAZy family. 24932683 PLNlncRbase
EL1389 TU506 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1390 TU51 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. The apcGenes of TU4652 and TU781 are a laccase 3 (GL29234) and a glyoxal oxidase precursor (GL20538), respectively, which belong to the lignin degradation pathway. In contrast, The apcGenes of TU51, TU4779, and TU4684 are an alpha-glucosidase (GL30020), a putative hydrolase (GL19744), a chitinase 1 (GL24376), respectively, all of which belong to CAZy family. 24932683 PLNlncRbase
EL1391 TU5846 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1392 TU6607 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1393 TU6608 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. 24932683 PLNlncRbase
EL1394 TU718 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A On the other hand, the expression profiles of 5 lincRNAs were negatively correlated with those of their apcGenes (Figure 5B,r<-0.8). The apcGenes of TU718, TU1378, TU3327, and TU5007 are a putative hydrolase (GL15069), a Barwin-related endoglucanase (GL18494), a putative hydrolase (GL27846), and an alphaamylase (GL24914), respectively, which all belong to CAZy family. 24932683 PLNlncRbase
EL1395 TU781 RNA-seq, qRT-PCR fruiting bodies, mycelia and primordia stages up-regulated N/A The expression profiles of 11 lincRNAs were positively correlated with their corresponding apcGenes (r>0.8; Figure 5A). The apcGenes of TU5846, TU506, TU6607, TU6608, TU1273, and TU1403 are all CYP450 genes. The apcGenes of TU4652 and TU781 are a laccase 3 (GL29234) and a glyoxal oxidase precursor (GL20538), respectively, which belong to the lignin degradation pathway. 24932683 PLNlncRbase
EL1400 Tug1 Northern blots and in situ hybridization, knockdown, Immunofluorescent staining and microarray analyses retina N/A expression Tug1 is necessary for the proper formation of photoreceptors in the developing rodent retina. 15797018
EL1400 Tug1 qRT-PCR, knockdown, MTT, TUNEL and Annexin V-FITC assays and western blot, GSIS, ELISA and immunochemistry mouse pancreatic β cell up-regulated expression Knockdown of lncRNA TUG1 expression resulted in an increased apoptosis ratio and decreased insulin secretion in β cells both in vitro and in vivo 25871529
EL1400 Tug1 RNA-seq, overexpression mouse hepatocytes and liver sinusoidal endothelial cells LSECs down-regulated expression Overexpression of TUG1 attenuated cold-induced apoptosis in mouse hepatocytes and liver sinusoidal endothelial cells LSECs, in part by blocking mitochondrial apoptosis and endoplasmic reticulum (ER) stress pathways. TUG1 attenuated apoptosis, inflammation, and oxidative stress in vivo in livers subjected to cold storage. Overexpression of TUG1 also improved hepatocyte function and prolonged hepatic graft survival rates in mice. These results suggest that the lncRNA TUG1 exerts a protective effect against cold-induced liver damage by inhibiting apoptosis in mice, and suggests a potential role for TUG1 as a target for the prevention of cold-induced liver damage in liver transplantation. 26785829
EL1430 uc022axw.1 lncRNA microarray human bone marrow mesenchymal stem cells (MSCs) up-regulated expression The results showed that the two up-regulated lncRNAs are likely to play important roles in osteogenic differentiation process。 25634249
EL1431 UCA1 N/A Human Liver Stem Cell N/A interaction CUDR plays a positive potential role in liver cancer stem cell through the cascade of CUDR-HULC/CUDR-β-catenin signaling. 26347501
EL1436 Uhg1 N/A N/A N/A expression We have identified two unusually compact box c/d multi-snorna host genes in d. melanogaster, duhg1 and duhg2, similar in their organization to the corresponding vertebrate non-protein-coding host genes. 11302516
EL1437 Uhg2 N/A N/A N/A expression We have identified two unusually compact box c/d multi-snorna host genes in d. melanogaster, duhg1 and duhg2, similar in their organization to the corresponding vertebrate non-protein-coding host genes. 11302516
EL1440 VAI a peptide phosphorylation assay, U.V. crosslinking experiments and filter binding assay N/A N/A interaction Eber-1, eber-2 and vai rna exhibit mutually competitive binding to the native or recombinant enzyme 7901835
EL1440 VAI construct mutants N/A N/A expression Analysis of the mutant's growth defect indicates that the adenovirus vai rna is required for efficient translation of viral mrnas at late times after infection. 6297772
EL1440 VAI isothermal titration calorimetry and gel electrophoresis N/A N/A interaction Autophosphorylation assays confirmed that both EBER(I) and VA(I) are inhibitors of PKR activation, and profiled the kinetics of the inhibition. Binding affinities of dsRNAs to PKR double-stranded RNA-binding domains (dsRBDs) were determined by isothermal titration calorimetry and gel electrophoresis. 16580685
EL1440 VAI N/A N/A N/A interaction The virus-associated rnas, va rnai and va rnaii, function as suppressors of rnai by interfering with the activity of dicer. the va rnas bind dicer and function as competitive substrates squelching dicer. 16014917
EL1441 VAII N/A N/A N/A interaction The virus-associated rnas, va rnai and va rnaii, function as suppressors of rnai by interfering with the activity of dicer. the va rnas bind dicer and function as competitive substrates squelching dicer. 16014917
EL1442 Vax2os N/A photoreceptor progenitors in the mouse retina N/A N/A regulate cell cycle in the mammalian retina during development. the overexpression of Vax2os1 in the developing early postnatal mouse retina causes an impaired cell cycle progression of photoreceptor rogenitors toward their final committed fate and a consequent delay of their differentiation processes. At later developmental stages, this perturbation is accompanied by an increase of apoptotic events in the photoreceptor cell layer, in comparison with control retinas, without affecting the proper cell layering in the adult retina. Similar results are observed in mouse photoreceptor-derived 661W cells in which Vax2os1 overexpression results in an impairment of the cell cycle progression rate and cell differentiation. 22128341
EL1442 Vax2os RT-PCR and RNA in situ hybridization retina N/A interaction We found a significant reduction of the expression levels of one of these nats, vax2os (vax2 opposite strand) in a mouse mutant carrying the inactivation of vax2, the corresponding sense gene. 15703187
EL1445 VL30 RNAs genetic subtraction and microarray analysis, In situ hybridization neural stem cell (NSC) N/A expression Vl30 is enriched in multiple stem cell populations and may have roles in determining "stemness", or stem cell function. 14651920
EL1445 VL30 RNAs N/A N/A N/A interaction Psf also contains two rna-binding domains (rbd) that form a complex with a noncoding vl30 retroelement rna, releasing psf from a gene and reversing repression. 16079199
EL1445 VL30 RNAs siRNA mouse steroidogenic adrenal cells N/A interaction Mvl30 rna regulates steroidogenesis, and possibly other physiological processes of mice, by complex formation with psf. 14704271
EL1445 VL30 RNAs Southern hybridization analyses an immunodeficient mouse model N/A expression The metastatic effect might be mediated directly by a noncoding mvl30-1 rna or by a peptide or small protein encoded by one of the short orfs in the mvl30-1 rna. 11959915
EL1449 VsENOD40 RT-PCR roots up-regulated N/A VsENOD40 expression during Rhizobium-induced nodule formation on Vicia sativa roots. VsENOD40 is expressed at a high level in the pericycle of the nodule vascular bundle . vetch ENOD40 is only expressed in the uninfected cells in this zone. while in pea ENOD40 is expressed in both the uninfected and infected cells of this zone. 7548828 PLNlncRbase
EL1452 WFDC21P knockdown mouse bone marrow cells N/A N/A The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. 24744378
EL1458 XACT Gene expression study human pluripotent cells N/A N/A act a role in the control of human X-chromosome inactivation (XCI) initiation. 23334669
EL1459 XIST N/A N/A N/A interaction We describe gene targeting of xist, and provide evidence for its absolute requirement in the process of x chromosome inactivation. 8538762
EL1459 XIST Targeted Structure-Seq N/A N/A expression We use this approach to probe the full-length Xist lncRNA to develop new models for functional elements within Xist, including the repeat A element in the 5'-end of Xist. This analysis also identified new structural elements in Xist that are evolutionarily conserved, including a new element proximal to the C repeats that is important for Xist function. 26646615
EL1460 Xist chemical and enzymatic probes and FRET experiments; combination of RNP affinity chromatography, immunoprecipitation; assays, mass spectrometry, and Western blot analysis mouse ES cell N/A N/A N/A 20052282
EL1460 Xist compared between freshly-isolated and cultured dental mesenchymal cells mouse dental mesenchymal cells down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue N/A loss of odontogenic potential 26986487
EL1460 Xist mutant mutant male and female mice N/A expression The xist rna is required for female dosage compensation but plays no role in spermatogenesis. 9009199
EL1460 Xist mutant mouse embryonic fibroblasts N/A mutation Loss of xist rna destabilizes the inactive state in somatic cells, leading to an increased reactivation frequency of an x-linked gfp transgene and of the endogenous hypoxanthine phosphoribosyl transferase (hprt) gene in mouse embryonic fibroblasts. 11352938
EL1460 Xist mutation mouse embryonic stem cells N/A expression Silencing requires a conserved repeat sequence located at the 5' end of xist. 11780141
EL1460 Xist N/A mice embryos, differentiating embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) N/A expression Ectopic Xist RNA induction and subsequent X-linked gene silencing is sex specific in embryos and in differentiating embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs). A higher frequency of X(ΔTsix)Y male cells displayed ectopic Xist RNA coating compared with X(ΔTsix)X female cells. This increase reflected the inability of X(ΔTsix)Y cells to efficiently silence X-linked genes compared with X(ΔTsix)X cells, despite equivalent Xist RNA induction and coating. Silencing of genes on both Xs resulted in significantly reduced proliferation and increased cell death in X(ΔTsix)X female cells relative to X(ΔTsix)Y male cells. The increased expression of one or more X-inactivation escapees activates Xist and, separately, helps trigger X-linked gene silencing. 26739568
EL1460 Xist N/A ES cells N/A expression Xist had to be activated within 48 hr of differentiation to effect silencing, suggesting that reversible repression by xist is a required initiation step that might occur during normal x inactivation in female cells. 10882105
EL1460 Xist peptide nucleic acid (PNA) interference mapping N/A N/A N/A A single 19-bp antisense cell-permeating pna targeted against a particular region of xist rna caused the disruption of the xi. 11481485
EL1460 Xist RT-PCR,RNA and DNA Fluorescence in Situ Hybridization,Immunofluorescence and Antibodies ES cell N/A interaction It coats and silences 1 of the 2 X chromosomes in female cells and initiates a chromosomewide change in chromatin structure that includes the recruitment of Polycomb proteins 19164542
EL1461 XLOC_000078 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1463 XLOC_000495 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1465 XLOC_000629 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1466 XLOC_000775 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1467 XLOC_000829 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1468 XLOC_000869 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1469 XLOC_000909 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1470 XLOC_000999 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1471 XLOC_001095 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1472 XLOC_001234 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1473 XLOC_001235 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1476 XLOC_004026 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1477 XLOC_004031 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1479 XLOC_004186 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1480 XLOC_004275 qRT-PCR reproductive stage N/A N/A XLOC_004275 are highly expressed in sperm (Figure 5A, D),and this type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1481 XLOC_004478 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1482 XLOC_004507 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1483 XLOC_004531 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1485 XLOC_004689 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1486 XLOC_004714 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1487 XLOC_004798 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1488 XLOC_004876 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1489 XLOC_004881 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1490 XLOC_004932 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1491 XLOC_004933 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1492 XLOC_004944 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1493 XLOC_005031 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1495 XLOC_007072 qRT-PCR reproductive stage N/A N/A lncRNA (XLOC_0063639 or XLOC_007072) that is highly expressed during the reproductive stage were introduced into rice protoplasts separately. Both XLOC_0063639 and XLOC_007072 dramatically increased the mRNA abundance of corresponding miRNA (OsmiR160 and OsmiR164) targets (LOC_Os02g36880 for miR164 [59]; LOC_Os06G47150 and LOC_Os10g33940 for miR160 [60]) in their transiently expressed protoplasts, suggesting that XLOC_0063639 and XLOC_007072 indeed inhibited the functions of OsmiR160 and miR164, respectively (Figure 6C,E-H). 25517485 PLNlncRbase
EL1498 XLOC_009232 qRT-PCR reproductive stage N/A N/A XLOC_009232 is specifically expressed in coleoptiles (Figure 5C),and this type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C;Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1504 XLOC_016182 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1505 XLOC_018316 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1506 XLOC_037529 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1507 XLOC_040350 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1508 XLOC_057324 qRT-PCR panicle development and fertility N/A N/A More importantly, one lncRNA, XLOC_057324, is demonstrated to play a role in panicle development and fertility. lncRNA (XLOC_057324) that is highly expressed in reproductive organs in relation to its physiological function in rice plants. This lncRNA is specifically expressed in young panicles and pistils (expression was restricted to ovules), suggesting that XLOC_057324 might play a role in regulating panicle and/or pistil development (Figure 7A,B). 25517485 PLNlncRbase
EL1509 XLOC_057981 qRT-PCR reproductive stage N/A N/A This type of lncRNA was expressed during the integrated sexual reproduction process (Figure 3C; Additional file 2), indicating that lncRNAs may function throughout the entire reproductive process in rice. 25517485 PLNlncRbase
EL1510 Xlsirts molecular beacons N/A N/A expression Destruction of either of these transcripts results in disruption of the cytokeratin cytoskeleton in a transcript-specific manner and interferes with proper formation of the germinal granules and subsequent development of the germline. 16000384
EL1512 XRN1 RNA-seq, qRT-PCR yeast N/A N/A The majority of XUTs strongly accumulate in lithium-containing media, indicating that they might have a role in adaptive responses to changes in growth conditions. Notably, RNAPII chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) analysis of Xrn1-deficient strains revealed a significant decrease of RNAPII occupancy over273 genes with antisense XUTs. These genes show an unusual bias for H3K4me3 marks and require the Set1 histone H3 lysine 4 methyl-transferase for silencing. Furthermore, abolishing H3K4me3 triggers the silencing of other genes with antisense XUTs, supporting a model in which H3K4me3 antagonizes antisense ncRNA repessive activity. Our results demonstrate that antisense ncRNA-mediated regulation is a general regulatory pathway for gene expression in S. cerevisiae. 21697827
EL1513 Yam-1 ChIP-seq Mouse C2C12 myoblasts (MBs) down-regulated N/A Yam-1 is positively regulated by YY1, Yam-1 is downregulated upon differentiation and acts as an inhibitor of myogenesis.Yam-1 functions through in cis regulation of miR-715, which in turn targets Wnt7b. 23942234
EL1519 Zfhx2os gene-targeting approach mouse brain N/A interaction The expression of zfh-5 is additionally regulated by a mechanism depending on this antisense rna. 16257534
EL1521 Zm401 RT-PCR flower development up-regulated N/A zm401 likely functions in pollen growth and/or development. RT-PCR amplification demonstrated that the ZM13-driven zm401 gene was spatially expressed in tobacco pollens. It was found that all transgenic tobacco plants expressing zm401 showed various levels of sterility, ranging from abortive flower development to male sterility. Further analyses on anther development of transgenic plants indicated multiple abnormalities in the late stages of anther development. These abnormalities include lagged degradation of the tapetum and connective tissue, failed deposition of fibrous bands in endothecium cells, and aborted pollen grain development. These results strongly suggest that zm401 plays an essential role in anther development. However the exact functions of zm401 is still unclear, and further analysis of zm401 is required to determine the exact mechanism involved in anther development. 10.1007/s10681-005-5272-2 PLNlncRbase
EL1522 Zm401 qRT-PCR pollens up-regulated N/A Zm401 is involved in the regulation of pollen development. Over expression of Zm401 in maize caused smaller tassels, degenerate or shriveled anthers. Zm401 may be involved in the development of male reproductive organs. Zm401, as a non-coding RNA, plays an essential role in pollen development. Zm401 gene is involved in the late stage of pollen development of maize. Zm401-overexpressed transgenic maize was generated to investigate its function in pollen development. (Dai et al., 2007) Zm401,is expressed specifically in pollens. Forward and reverse genetic studies have shown a function for Zm401 in regulating the expression of critical genes necessary for pollen development including ZmMADS2, MZm3-3 and ZmC5. MZm3-3 was up-regulated in Zm401 mutants while ZmMADS2 and ZmC5 were both down-regulated. Over-expression of Zm401 severely affects pollen development due to abnormal tassels and degenerate anthers. (Au et al., 2011) Zm401 is expressed primarily in the anthers (tapetal cells as well as microspores) in a developmentally regulated manner. That is, it is expressed from floret forming stage, increasing in concentration up to mature pollen. Knockdown of zm401 significantly affected the expression of ZmMADS2, MZm3-3, and ZmC5, critical genes for pollen development. zm401 could be one of the key growth regulators in anther development, the expression of zm401 is associated with the floret development, especially with the development of tapetal cells and microspores. (Ma et al., 2008) ZM401 was specifically or preferentially expressed in mature pollen. ZM401 was transcribed from tetrad stage of microspore development and increased in concentration up to mature pollen, which suggested that ZM401 belongs to lategene in pollen development. (Dai et al., 2004) 21525783, 18465785, 400866 PLNlncRbase
EL1523 Zm401p10 Western blot/RT-PCR anther development up-regulated N/A Overexpression of Zm401p10 in maize retarded tapetal degeneration and caused microspore abnormalities. The Zm401 gene is one of the major components of the molecular network regulating maize anther development and male fertility, and that Zm401p10 is expressed from the longest ORF of the gene. Zm401p10 plays a major role in pollen development. Overexpression of Zm401p10 in maize resulted in several severe phenotypes, including retardation of tapetum degeneration, accompanied by pollen abortion or pollen grains with low viability. These data suggest that Zm401p10 acts within the tapetum to promote normal pollen development and postmeiotic tapetal degradation.the overexpression of Zm401p10 did not affect ear development or fertilisation. Zm401p10 might play a role in guiding normal early anther development by maintaining the transcription of cysteine proteinases. Zm401p10 overexpression might abolish tapetum flavonoid biosynthesis and lead to male sterility. 10.1071/FP08187 PLNlncRbase
EL1525 ZmIPS1 qRT–PCR phosphate balance up-regulated N/A The expression patterns of other members of the TPSI1/Mt4 family in monocots were also investigated. The induced expressions of OsIPS1, HvIPS1, ZmIPS2 and TalIPS2 were stronger than those of OsIPS2, HvIPS2 ZmIPS1 and TalIPS1 in roots after 4 or 10 d of Pi starvation, whereas higher induced expressions of OsIPS2, HvIPS1, ZmIPS1 and TalIPS1 were detected in shoots. 10.1111/j.1365-3040.2005.01272.x PLNlncRbase
EL1528 ZNF667-AS1 microarray, qRT-PCR isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal human mammary epithelial cells (HMECs) from 4 individuals down-regulated epigenetics The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'-deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. 26646903
EL1530 ZPR4 qRT-PCR/RT-PCR cold, drought and highlight up-regulated N/A We found that 303 lncRNAs (including 245 poly (A)+ and 58 poly(A)- lncRNAs) were differentially expressed under at least one of the stress conditions, lncRNA AT2G36307 is upregulated by cold/drought/highlight stresses.(details are listed in Appendix S2) 25256571 PLNlncRbase
EL1299 TCONS_00049512 RNA-seq/qRT-PCR wood formation up-regulated N/A In our study, ptc-miR1445 was predicted to target TCONS_00049512, which has been predicted to function in cleaving the transcripts of development-related or stress responsive genes in Populus (Lu et al. 2008). Besides ptc-miR1445, miRNAs that were specifically expressed in xylem and reportedly participate in formation of tension wood (Lu et al. 2005, 2008; Puzey et al. 2012) were predicted to regulate some of the lncRNAs identified in our study. For example, ptr-miR172, which was only suppressed in compression tissue (Lu et al. 2005), may target TCONS_00012272 and TCONS_00012273, which were detected in our study and showed a type C expression pattern (TW 25230698 PLNlncRbase
EL1276 TCONS_00012273 RNA-seq/qRT-PCR wood formation up-regulated N/A In our study, ptc-miR1445 was predicted to target TCONS_00049512, which has been predicted to function in cleaving the transcripts of development-related or stress responsive genes in Populus (Lu et al. 2008). Besides ptc-miR1445, miRNAs that were specifically expressed in xylem and reportedly participate in formation of tension wood (Lu et al. 2005, 2008; Puzey et al. 2012) were predicted to regulate some of the lncRNAs identified in our study. For example, ptr-miR172, which was only suppressed in compression tissue (Lu et al. 2005), may target TCONS_00012272 and TCONS_00012273, which were detected in our study and showed a type C expression pattern (TW 24892290 PLNlncRbase
EL1294 TCONS_00039944 RNA-seq/qRT-PCR wood formation down-regulated N/A Figure 9a shows that a negative relationship between miRNAs and their potential target lncRNAs were detected; for example, miR2 (Ptc-miR168b-5p) is expressed in OW(OW 25230698 PLNlncRbase
EL1531 Apela RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization N/A N/A interaction Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. 24407481
EL1532 APELA RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization N/A N/A interaction Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. 26387754, 25639753, 20153842, 24316148, 24407481
EL1533 apela RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization early zebrafish embryogenesis N/A interaction Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. 24407481
EL0388 ENOD40-1 Western blotting, peptide mass fingerprinting nodules N/A expression In vitro translation of soybean ENOD40 mRNA in wheat germ extracts revealed that the conserved nucleotide sequence at the 5′ end (region I) encodes two peptides of 12 and 24 aa residues (peptides A and B). ENOD40 peptides are involved in the control of sucrose use in nitrogen-fixing nodules. 11842184
EL1534 Gm34302 Northern Blot, Western Blot, Co-immunoprecipitations (CoIPs) Knockout mice, Transgenic mice N/A interaction DWORF is a transmembrane peptide that interacts with SERCA proteins and enhances muscle contractility 26816378
EL1535 DWORF Northern Blot, Western Blot, Co-immunoprecipitations (CoIPs) Human Heart Failure Tissue N/A interaction We discovered a putative muscle-specific long noncoding RNA that encodes a peptide of 34 amino acids and that we named dwarf open reading frame (DWORF). 26816378
EL1536 MRLN Radioisotopic In Situ Hybridization, Co-immunoprecipitations and Western Blot Analysis, Real-time PCR N/A N/A interaction We discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncoding RNA. MLN as an important regulator of skeletal muscle physiology. 25640239
EL1537 Mrln Radioisotopic In Situ Hybridization, Co-immunoprecipitations and Western Blot Analysis, Real-time PCR pseudopregnant female ICR mice N/A interaction We discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncoding RNA. MLN as an important regulator of skeletal muscle physiology. 25640239
EL1538 SclA RT-PCR, in situ hybridization Drosophila heart N/A interaction We describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart. 23970561
EL1539 SclB RT-PCR, in situ hybridization Drosophila heart N/A interaction We describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart. 23970561
EL1540 tal-1A Immunohistochemistry, In situ hybridisation, sequencing N/A N/A expression tal function is mediated by several 33-nucleotide–long open reading frames (ORFs), which are translated into 11-amino-acid–long peptides. 17486114, 17439302
EL1541 tal-2A Immunohistochemistry, In situ hybridisation, sequencing N/A N/A expression tal function is mediated by several 33-nucleotide–long open reading frames (ORFs), which are translated into 11-amino-acid–long peptides. 17486114, 17439302
EL1542 tal-3A Immunohistochemistry, In situ hybridisation, sequencing N/A N/A expression tal function is mediated by several 33-nucleotide–long open reading frames (ORFs), which are translated into 11-amino-acid–long peptides. 17486114, 17439302
EL1543 tal-AA Immunohistochemistry, In situ hybridisation, sequencing N/A N/A expression tal function is mediated by several 33-nucleotide–long open reading frames (ORFs), which are translated into 11-amino-acid–long peptides. 17486114, 17439302
INTERACTION
ID lncRNA
Name
Interaction
target
Level of
interaction
Type of
interaction
Description PMID Source
EL0005 4930570G19Rik Negr1 RNA-DNA regulation In vitro knockdown of the long non-coding RNA resulted in significant down-regulation of Negr1 mRNA expression, NEGR1 protein levels and neurite length whereas over-expression enhanced Negr1 mRNA expression, NEGR1 protein levels and increased neurite length. The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively. 26723899
EL0009 6430411K18Rik Rtl1/Peg11 RNA-RNA regulation Several additional mirnas are processed from antipeg11 and that these regulate rtl1/peg11 in trans by guiding risc-mediated cleavage of its mrna. 15854907
EL0010 9130001E16Rik Gata6 RNA-RNA co-expression The expression of Gata6bt was negatively correlated with Gata6, being up-regulated during pluripotent EB stages and down-regulated during progressive lineage specification. 18562676 LncRNADisease
EL0011 9530018H14Rik p100 and CBP RNA-Protein binding In the limb mesenchyme, LncRNA-HIT was found to be retained in the nucleus, forming a complex with p100 and CBP. 26633036
EL0012 A130040M12Rik PSF RNA-Protein binding Binding of mouse VL30 (A130040M12Rik) retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. 14704271 LncRNADisease
EL0012 A130040M12Rik PSF RNA-Protein binding VL30-1 RNA binds and releases PSF from Rab23. 19805375 LncRNADisease
EL0014 AATBC JNK, NRF2 RNA-DNA regulation The apoptosis following AATBC knockdown was mediated by activation of phosphorylated JNK and suppression of NRF2. 25473900
EL0016 AB073614 ERK1/2 and AKT-mediated signaling pathway RNA-Protein regulation western blot assays indicated that lncRNA AB073614 may exert its function by targeting ERK1/2 and AKT-mediated signaling pathway. 26299803
EL0033 Adapt15 TDP-43 RNA-Protein binding UV-induced gadd7 directly binds to TAR DNA-binding protein (TDP-43) and interferes with the interaction between TDP-43 and cyclin-dependent kinase 6 (Cdk6) mRNA, resulting in Cdk6 mRNA degradation. 23103768
EL0033 Adapt15 Cdk6 RNA-RNA regulation UV-induced gadd7 directly binds to TAR DNA-binding protein (TDP-43) and interferes with the interaction between TDP-43 and cyclin-dependent kinase 6 (Cdk6) mRNA, resulting in Cdk6 mRNA degradation. 23103768
EL0033 Adapt15 gadd45 and gadd153 RNA-RNA co-expression Near identical responses were also observed for gadd45 and gadd153 rnas, suggesting coordinate regulation of adapt15, gadd45, and gadd153. 8638945
EL0039 AF339813 NUF2 RNA-Protein regulation Through bioinformatics analysis and knockdown NUF2 in PC cells, we found LncRNA AF339813 was positively regulated by NUF2. We further demonstrated that knockdown of AF339813 by siRNA in PC cells significantly reduced cell proliferation and promoted apoptosis. 26045769
EL0040 AFAP1-AS1 several small GTPase family members RNA-Protein regulation AFAP1-AS1 knockdown affected the expression levels of several small GTPase family members and molecules in the actin cytokeratin signaling pathway. 26245991
EL0040 AFAP1-AS1 actin filament associated protein 1 (AFAP1) RNA-Protein regulation AFAP1-AS1 knockdown also increased the expression of its antisense protein coding gene, actin filament associated protein 1 (AFAP1). 26245991
EL0040 AFAP1-AS1 actin filament associated protein 1 (AFAP1) RNA-Protein regulation AFAP1-AS1 knockdown also increased AFAP1 protein expression. 26246469
EL0044 Airn G9a RNA-Protein binding Recruits G9a histone methyltransferase to epigenetically silence some target genes. 11845212 LncRNADisease
EL0044 Airn Igf2r RNA-DNA regulation Controls Igf2r imprinting cluster in mouse 16874305 LncRNADisease
EL0044 Airn Ig2fr RNA-RNA co-expression Neuron-specific lack of Airn expression results in neuronspecific lack of silencing at the Ig2fr locus. 18184812 LncRNADisease
EL0044 Airn Slc22a3 RNA-DNA regulation The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. 18988810 LncRNADisease
EL0044 Airn G9a RNA-Protein binding The Airn noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Airn accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. 18988810 LncRNADisease
EL0044 Airn Slc22a3 promoter RNA-DNA regulation Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. 18988810
EL0044 Airn G9a RNA-Protein binding The Airn RNA also binds to G9a and appears to target this enzyme to a silenced gene in the cluster. 19239885 LncRNADisease
EL0044 Airn G9a RNA-Protein binding The antisense transcript AIRN that is associated with the chromatin-modifying complex G9a. 19571010 LncRNADisease
EL0044 Airn Igf2r DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
EL0044 Airn Slc22a2 DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
EL0044 Airn Slc22a3 DNA-DNA regulation Deletion of the Airn promoter on the paternal allele results in aberrant activation of paternal Igf2r, Slc22a2, and Slc22a3 genes in cis. 19727951 LncRNADisease
EL0044 Airn Igf2r RNA-RNA co-expression Insertion of a polyadenylation cassette leading to truncation of the Air transcript resulted in the derepression of imprinted genes in the locus, which is suggestive of a direct role for long ncRNAs in imprinting of insulin-like growth factor 2 receptor (Igf2r). 21831473 LncRNADisease
EL0044 Airn G9a RNA-Protein binding The Airn lncRNA was found to coat its target genes but instead recruits the G9a histone methyltransferase rather than the subunits of PRC2 21874119 LncRNADisease
EL0044 Airn G9a RNA-Protein binding Airn transcription unit recruits G9a to its target promoter to bring about gene silencing 21925379 LncRNADisease
EL0044 Airn Igf2r DNA-DNA regulation A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. 22396659 LncRNADisease
EL0053 AK081227 Mecp2 DNA-Protein regulation overexpression of AK081227 mediated by the Mecp2 loss was associated with the downregulation of its host coding protein gene, the gamma-aminobutyric acid receptor subunit Rho 2 (Gabrr2) 23611944
EL0061 AK133808 Rab11b RNA-RNA co-expression A variety of ncRNAs were broadly upregulated in OLPs, PMOs and MYOs including AK141895 and AK133808, associated with the Slc44a1 and Rab11b genomic loci, respectively. 20137068 LncRNADisease
EL0061 AK133808 Slc44a1 RNA-RNA co-expression A variety of ncRNAs were broadly upregulated in OLPs, PMOs and MYOs including AK141895 and AK133808, associated with the Slc44a1 and Rab11b genomic loci, respectively. 20137068 LncRNADisease
EL0070 alpha-250 and alpha-280 S14 RNA-DNA regulation Alpha-250 and alpha-280 stimulate s14 mrna transcription, whereas free ribosomal protein s14 inhibits it. 7867928
EL0071 alpha-280/250 RPS14 RNA-DNA regulation Regulates RPS14 transcription in humans. 7867928 LncRNADisease
EL0073 Alu lncRNAs Pol II RNA-Protein binding B2 and Alu RNAs bind directly and tightly to Pol II and co-occupy the promoters of repressed genes along with the polymerase 19307572
EL0075 antisense TGF beta 3 TGF beta 3 mRNA RNA-RNA regulation The temporally controlled appearance of rna complementary to tgf beta 3 suggests that this molecule may play a role in the regulation of tgf beta 3 production in the heart. 1511174
EL0076 AOC4P vimentin RNA-Protein binding AOC4P binds to vimentin and promotes its degradation. 26160837
EL0076 AOC4P UHRF1 RNA-Protein regulation UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its β-transducin repeat-containing protein (TrCP)-mediated ubiquitination. 26768845
EL0080 APOA1-AS APOA1 RNA-Protein regulation APOA1-AS can modulate distinct histone methylation patterns that mark active and/or inactive gene expression through the recruitment of histone-modifying enzymes. 24388749
EL0081 APOLO PID RNA-DNA regulation Altering APOLO expression affects chromatin loop formation, whereas RNA-dependent DNA methylation, active DNA demethylation, and Polycomb complexes control loop dynamics. This dynamic chromatin topology determines PID expression patterns. 25018019 PLNlncRbase
EL0088 ASCO-RNA At2G33830 RNA-RNA binding By using an in vitro binding assay for an AS target (the auxinregulated protein gene At2g33830), we showed that incubation with nonlabeled At2g33830 mRNA or the ASCO-RNA significantly diminishes the amount of AS target immunoprecipitated 25073154, 25073153 PLNlncRbase
EL0093 ASncmtRNAs Dicer RNA-Protein binding the ASncmtRNAs are bound to Dicer. 25100722
EL0093 ASncmtRNAs survivin RNA-Protein regulation knockdown of ASncmtRNAs potentiates apoptotic cell death by inhibiting survivin expression, a member of the inhibitor of apoptosis (IAP) family. 25100722
EL0094 asOct4-pg5 41186 RNA-RNA regulation These results indicate that the lncRNA asOct4-pg5 may function to regulate multiple Oct4 related transcripts. 21151833 LncRNADisease
EL0095 AT102202 mRNA-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) RNA-Protein regulation In particular, the lncRNA AT102202 and its potential targets mRNA-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) were identified. 25563320
EL0168 At4 PHO2 RNA-RNA regulation In contrast to at4, pho2 accumulates Pi in the shoots under both high- and low-Pi growth conditions and shows higher Pi uptake rates relative to wild type. 16460506, 21525783, 9880366 PLNlncRbase
EL0169 At4-1 miR399/PHO2 RNA-RNA binding IPS1 and At4 directly inhibits miR-399 activity. 17643101, 23726911 PLNlncRbase
EL0170 At4-2 miR399/PHO3 RNA-RNA binding IPS1 and At4 directly inhibits miR-399 activity. 17643101, 23726911 PLNlncRbase
EL0171 At4-3 miR399/PHO4 RNA-RNA binding IPS1 and At4 directly inhibits miR-399 activity. 17643101, 23726911 PLNlncRbase
EL0216 ATXN8OS GAT4 RNA-RNA co-expression SCA8 CUG(exp) transcripts trigger splicing changes and increased expression of the CUGBP1-MBNL1 regulated CNS target, GABA-A transporter 4 (GAT4/Gabt4). 19680539 LncRNADisease
EL0221 B130024G19Rik Coup-TfII RNA-RNA co-expression We also have identified a candidate imprinted long antisense ncRNA, AK045070, that encompasses >45 kb and shows expression within the thalamus, pyramidal cells in the ventral hippocampus, and cortical amygdalar area. The adjacent candidate imprinted expressed gene, Coup-TfII, an important nuclear receptor involved in regulating various hormonal and brain functions, also exhibits a similar expression profile within these regions 18184812 LncRNADisease
EL0222 B2 SINE RNA RNA polymerase II DNA-DNA regulation Transposable B2 SINE elements can provide mobile RNA polymerase II promoters. 11326281 LncRNADisease
EL0222 B2 SINE RNA CELO DNA-TF regulation CELO protein Gam1 was able to mediate transcriptional activation of these B2 SINE-containing RNAs. 12729754 LncRNADisease
EL0222 B2 SINE RNA Pol II RNA-Protein binding B2 rna potently inhibits transcription by binding to core pol ii with high affinity and specificity. 15300239
EL0222 B2 SINE RNA Pol II RNA-Protein binding A small noncoding rna polymerase iii transcript, b2 rna, associates with rna polymerase ii and represses transcription of specific mrna genes. 15300240
EL0222 B2 SINE RNA RNA polymerase II RNA-Protein binding A 33-nt piece of B2 RNA binds RNA polymerase II, associates with preinitiation complexes, but cannot repress transcription. 17307818 LncRNADisease
EL0222 B2 SINE RNA RNA polymerase II RNA-Protein binding In vitro B2 RNA assembles into preinitiation complexes on promoter DNA via its interaction with the polymerase, thus rendering the complexes inactive. 17307818
EL0222 B2 SINE RNA ALAS1 DNA-DNA regulation A B2 SINE can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression. 18929534 LncRNADisease
EL0222 B2 SINE RNA actin RNA-RNA co-expression Upon stress conditions such as heat shock, B2 expression is dramatically enhanced leading to repression of transcription for genes such as actin and hexokinase II. 19239885 LncRNADisease
EL0222 B2 SINE RNA hexokinase II RNA-RNA co-expression Upon stress conditions such as heat shock, B2 expression is dramatically enhanced leading to repression of transcription for genes such as actin and hexokinase II. 19239885 LncRNADisease
EL0222 B2 SINE RNA Comt1 DNA-DNA regulation A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains.Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity (comparable to the human Val-Met polymorphism) which has a demonstrable behavioral phenotype across a variety of outbred genetic backgrounds. 20618449 LncRNADisease
EL0222 B2 SINE RNA Comt1 DNA-DNA regulation Comt1 is differentially expressed among the strains, and this differential expression is cis-regulated. A B2 short interspersed nuclear element (SINE) was inserted in the 3'-untranslated region (3'-UTR) of Comt1 in 14 strains generating a common haplotype that correlates with gene expression. A haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors. 20659173 LncRNADisease
EL0223 B4GALT1-AS1 B4GALT1 RNA-RNA regulation B4GALT1 in a divergent manner along with its long non-coding RNA (lncRNA) antisense counterpart B4GALT1-AS1 26315939
EL0224 BACE1-AS APP RNA-Protein regulation BACE1-AS is directly implicated in the increased abundance of Aβ 1–42 in Alzheimer’s disease. 18587408 LncRNADisease
EL0224 BACE1-AS BACE1 RNA-RNA regulation The BACE1-antisense transcript (BACE1-AS) regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo.expression of BACE1-AS increases BACE1 mRNA stability. 18587408 LncRNADisease
EL0224 BACE1-AS BACE1 RNA-RNA co-expression We report here that BACE1-antisense prevents miRNA-induced repression of BACE1 mRNA by masking the binding site for miR-485-5p. Indeed, miR-485-5p and BACE1-antisense compete for binding within the same region in the open reading frame of the BACE1 mRNA. 20507594 LncRNADisease
EL0224 BACE1-AS miR-485-5p RNA-RNA regulation We report here that BACE1-antisense prevents miRNA-induced repression of BACE1 mRNA by masking the binding site for miR-485-5p. Indeed, miR-485-5p and BACE1-antisense compete for binding within the same region in the open reading frame of the BACE1 mRNA. 20507594 LncRNADisease
EL0224 BACE1-AS miR-485-5p RNA-RNA binding masking the binding site for miR-485-5p 20507594
EL0224 BACE1-AS BACE1 RNA-DNA regulation When expression of lncRNA BACE1-AS was silenced using siRNA, BACE1 expression was downregulated and the antiproliferative and anti-invasive effects of anisomycin were reduced. 26783004
EL0226 BALR-6 Specificity Protein 1 (SP1) RNA-Protein regulation An enhancement of SP1-mediated transcription in the presence of BALR-6. 26694754
EL0227 BANCR p21 RNA-DNA regulation our findings suggest that down-regulation of BANCR contributes to the proliferation of colorectal cancer cells, at least in part, through the regulation of p21 protein. 25928067
EL0227 BANCR BRAF RNA-DNA regulation little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in gastric cancer. 26054683
EL0227 BANCR NF-κB1 RNA-TF regulation Down-regulation of BANCR contributed to a significant decrease of NF-κB1 (P50/105) expression and 3'UTR of NF-κB1 activity. Overexpression of NF-κB1 reversed the effect of BANCR on cancer cell growth and apoptosis. 26248136
EL0227 BANCR MiroRNA-9 (miR-9) RNA-RNA regulation MiroRNA-9 (miR-9) targeted NF-κB1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. 26248136
EL0227 BANCR Ets-1 DNA-Protein regulation Ets-1 negatively regulated BANCR expression via the deacetylation of histones H3 within BANCR promoter. 26296467
EL0227 BANCR zeste homolog 2 (EZH2) RNA-Protein regulation BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. 26323637
EL0227 BANCR cyclin D1 RNA-Protein regulation BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. 26323637
EL0227 BANCR thyroid stimulating hormone receptor (TSHR) RNA-Protein regulation BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). 26323637
EL0234 Bc1 PABP RNA-Protein binding Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
EL0234 Bc1 eIF4A RNA-DNA regulation A specific interaction of bc1 rna with eif4a, an rna unwinding factor, and with poly(a)-binding protein. 12451124
EL0234 Bc1 PABP RNA-Protein binding In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
EL0234 Bc1 eukaryotic initiation factor 4A and poly(A) binding protein, the fragile X mental retardation protein RNA-Protein binding Interactions of this domain with eukaryotic initiation factor 4A and poly(A) binding protein mediate repression;BC1 RNA modulates translation-dependent processes in neurons and germs cells by directly interacting with translation initiation factors. 16330711
EL0237 BCYRN1 PABP RNA-Protein binding Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
EL0237 BCYRN1 PABP RNA-Protein binding In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
EL0237 BCYRN1 SRP9/14 heterodimer RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 17175535 LncRNADisease
EL0237 BCYRN1 G22 RNA-Protein co-expression when all upstream regions of the G22 gene were removed, expression was completely abolished, despite the presence of intact internal RNA polymerase III promoter elements 17175535
EL0237 BCYRN1 eIF4A RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 18316401 LncRNADisease
EL0237 BCYRN1 c-MYC DNA-Protein binding ChIP assay confirmed the binding of c-MYC to the promoter region of BCYRN1 gene. 25866480
EL0237 BCYRN1 the quadruplex-containing telomerase RNA RNA-RNA regulation An interaction between BC200 and the quadruplex-containing telomerase RNA was confirmed by pull-down assays of the endogenous RNAs. 26740632
EL0237 BCYRN1 RHAU RNA-Protein binding RHAU binds to an adenosine-rich region near the 3'-end of the RNA. RHAU truncations support binding that is dependent upon a region within the C terminus and is specific to RHAU isoform 1. 26740632
EL0237 BCYRN1 PABP RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 7684772 LncRNADisease
EL0237 BCYRN1 SRP9 RNA-Protein binding A protein that binds bc200 rna in vivo is immunoreactive with antibodies against srp9. 9605471
EL0238 BCYRN1P2 FMR1 RNA-Protein binding The neural phenotype of BC1 (BCYRN1P2) is consistent with its known interaction with both FMRP, the product of the fragile X mental retardation gene (FMR1), and with mRNAs regulated by FMRP. 19239885 LncRNADisease
EL0239 BDNF-AS BDNF RNA-RNA binding BDNF and antiBDNF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human. 17629449 LncRNADisease
EL0239 BDNF-AS BDNF RNA-RNA binding Human BDNF mRNA and BDNFOS (Opposite Strand) lncRNA form in-vivo RNA–RNA duplexes in brain, suggesting the possibility of post-transcriptional cis-regulation, by BDNFOS, of BDNF. 20951849 LncRNADisease
EL0246 BOK-AS1 WISP1 RNA-DNA regulation LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance. 25749038
EL0247 Borg Bone morphogenetic proteins (BMPs) DNA-Protein regulation Borg is a common target gene of bmps 9642273
EL0249 BRCA1 BRCA1 RNA-DNA regulation In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection. 26411689
EL0249 BRCA1 hnRNPUL1 RNA-Protein regulation In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection. 26411689
EL0251 BX647187 Hec1 RNA-Protein regulation LncRNA BX647187 was positively regulated by Hec1. 26612002
EL0253 bxd Ubx RNA-RNA co-expression Ubx and several bxd ncRNAs are expressed in nonoverlapping patterns in both embryos and imaginal discs, suggesting that transcription of these ncRNAs is associated with repression, not activation, of Ubx. 17174895 LncRNADisease
EL0253 bxd Ubx DNA-DNA regulation bxd contains enhancer elements for the nearby Ubx gene. 19191220 LncRNADisease
EL0256 C1orf74 Notch 1 RNA-DNA regulation Notch 1 can promote the lncRNA AK022798 expression and result in the formation of SGC7901/DDP and BGC823/DDP cells. 25763542
EL0257 C1QTNF9B-AS1 SET RNA-Protein regulation PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. 15930275 LncRNADisease
EL0261 C5T1lncRNA C5 RNA-RNA co-expression C5T1lncRNA is expressed predominantly in the nucleus and its expression correlates positively with C5 mRNA in various tissues (P=0.001) and in peripheral blood mononuclear cells (P=0.02) indicating transcriptional co-regulation. Knockdown results in a concurrent decrease in C5 mRNA levels but not of other neighbouring genes. lncRNA C5T1lncRNA is fully located in the associated region and influences transcript levels of C5, a gene previously linked to RA pathogenesis. 26673966
EL0262 C730029A08Rik EBF2 RNA-TF binding Blnc1 forms a ribonucleoprotein complex with transcription factor EBF2 to stimulate the thermogenic gene program. Further, Blnc1 itself is a target of EBF2, thereby forming a feedforward regulatory loop to drive adipogenesis toward thermogenic phenotype. 25002143
EL0263 C730036E19Rik TDP-43 RNA-Protein binding LncLSTR forms a molecular complex with TDP-43 to regulate expression of Cyp8b1, a key enzyme in the bile acid synthesis pathway, and engenders an in vivo bile pool that induces apoC2 expression through FXR. 25738460
EL0265 CADM1 CADM1 mRNA RNA-RNA co-expression CADM1-AS1 expression was positively associated with CADM1 mRNA expression in 786-O cells and ACHN cells. 25031695
EL0265 CADM1 TSLC1 RNA-RNA regulation A novel lncRNA, TSLC1-AS1, is the antisense transcript of tumor suppressor TSLC1. 25031725
EL0269 CAR Intergenic 10 ADAM12 RNA-DNA regulation Regulates gene expression of FANK1 and ADAM12 flanking genes through modulating the chromatin structure in cis. 20404130 LncRNADisease
EL0269 CAR Intergenic 10 FANK1 RNA-DNA regulation Regulates gene expression of FANK1 and ADAM12 flanking genes through modulating the chromatin structure in cis. 20404130 LncRNADisease
EL0272 CASC2 miR-21 RNA-RNA binding Furthermore,bioinformatics, luciferase reporter assays and pull-down assay confirmed that miR-21 binds to CASC2 in a sequence-specific manner. 25446261
EL0274 CBR3-AS1 AR RNA-Protein regulation The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. 22264502 LncRNADisease
EL0275 CCAL AP-2α RNA-Protein regulation CCAL promoted CRC progression by targeting activator protein 2α (AP-2α), which in turn activated Wnt/β-catenin pathway. 25994219
EL0276 CCAT1 miRNA-218-5p RNA-RNA binding these results suggest that CCAT1 is a driver of malignancy, which acts in part through 'spongeing' miRNA-218-5p. 25569100
EL0276 CCAT1 E-cadherin and N-cadherin RNA-Protein co-expression The expression of IncRNA-CCAT1 in tumor tissue was significantly higher than that in normal para-carcinoma tissue (P < 0.001), and the expression level of CCAT1was significantly correlated with local infiltration depth (P < 0.001), tumor staging (P < 0.001), vascular invasion (P < 0.001) and CA19-9 level (P < 0.001); but not related with age, gender, location of tumor, tumor differentiation level, size of primary lesion and level of CEA (P > 0.05). The expression of E-cadherin in tumor tissues was significantly lower than in normal para-carcinoma tissues (P < 0.001), and the expression of N-cadherin was significantly higher than that in normal para-carcinoma tissues. The decrease in expression of E-cadherin and increase in expression of N-cadherin were significantly correlated with local infiltration depth (P < 0.001), tumor staging (P < 0.001), vascular invasion (P < 0.001), tumor differentiation level (P < 0.001) and CA19-9 level (P < 0.001), however not related with age, gender, tumor location, size of primary lesion and CEA level (P > 0.05). CONCLUSION: CCAT1 plays an important role in the genesis, development, invasion and metastasis; it mediates the EMT process of colorectal cancer; and it's expected to be a new marker and treatment target in colorectal diagnosis and treatment. 26064266
EL0276 CCAT1 miR-490 RNA-RNA binding CCAT1 regulates miR-490 in gastric cancer (GC) cells. miR-490 can also repress CCAT1 expression. CCAT1 contains a putative miR-490-binding site, and deletion of this binding site abolishes their miR-490 responsiveness. 26825578
EL0278 CCAT2 c-Myc DNA-TF binding c-Myc could promote CCAT1 transcription by directly binding to its promoter region 25185650
EL0278 CCAT2 Wnt signaling pathway N/A regulation The abnormal expression of CCAT2 could influence the Wnt signaling pathway. 26442763
EL0282 CCDC26 KIT RNA-DNA regulation We suggest that CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression. A KIT inhibitor might be an effective treatment against the forms of AML in which CCDC26 is altered. 25928165
EL0283 CCEPR PCNA RNA-DNA regulation RNA pull-down assays confirmed that CCHE1 physically associates with proliferating cell nuclear antigen (PCNA) messenger RNA, consequently enhances the expression of PCNA. The expression of CCHE1 and PCNA is significantly correlated in cervical cancer tissues. 25921283
EL0287 CD99P1 miR-21, miR-31, miR-101, miR-29, miR-199, and let-7d RNA-RNA binding The sequences of the dysregulated microRNAs in IPF including miR-21, miR-31, miR-101, miR-29, miR-199, and let-7d were used to search NONCODE database containing 33,829 human lncRNAs. A total of 34 lncRNAs with potential binding sites to these microRNAs were identified. Four of them were inversely correlated to the microRNA expression in IPF. 26269497
EL0288 Cdc28 lncRNA Hog1 and RSC RNA-Protein regulation Cdc28 lncRNA mediates the establishment of gene looping and the relocalization of Hog1 and RSC from the 3' UTR to the +1 nucleosome to induce CDC28 expression. 24508389
EL0289 CDKN2B-AS1 ARF RNA-DNA regulation Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 INK4a RNA-DNA regulation Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 INK4b RNA-DNA regulation Binding to RNA contributes to CBX7 function and disruption of either interaction impacts the ability of CBX7 to repress the INK4b/ARF/INK4a locus and control senescence. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 CBX7 RNA-Protein binding Chromobox 7 (CBX7) within the polycomb repressive complex 1 (PRC1) binds to ANRIL. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 CBX7 RNA-Protein binding Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 PRC1 RNA-Protein binding Recruits Polycomb Repressor Complex 1 (PRC1) to epigenetically silence INK4b/ARF/INK4a tumour suppressor locus. 20541999 LncRNADisease
EL0289 CDKN2B-AS1 E2F1 DNA-TF regulation ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1. 20664976 LncRNADisease
EL0289 CDKN2B-AS1 CBX7 RNA-Protein binding Chromobox 7 (CBX7) within the polycomb repressive complex 1 (PRC1) has been shown to bind to ANRIL 20956613 LncRNADisease
EL0289 CDKN2B-AS1 p15 RNA-DNA regulation RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. 21151178 LncRNADisease
EL0289 CDKN2B-AS1 PRC2 RNA-Protein binding RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. 21151178 LncRNADisease
EL0289 CDKN2B-AS1 SUZ12 RNA-Protein binding RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus. 21151178 LncRNADisease
EL0289 CDKN2B-AS1 PRC1 RNA-Protein binding Although lncRNA-mediated regulation of INK4b-ARF-INK4a gene is not restricted to ANRIL, both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PRC2 RNA-Protein binding Although lncRNA-mediated regulation of INK4b-ARF-INK4a gene is not restricted to ANRIL, both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PRC1 RNA-Protein binding Both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PRC2 RNA-Protein binding Both polycomb repressive complex-1 (PRC1) and -2 (PRC2) interact with ANRIL to form heterochromatin surrounding the INK4b-ARF-INK4a locus, leading to its repression. 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PcG RNA-Protein binding PcG repress the expression of INK4b-ARF-INK4a locus by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL). 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PcG RNA-Protein binding The important role of PcG in mediating repression of the INK4b-ARF-INK4a locus, by directly binding to the long noncoding RNA (lncRNA) transcript antisense noncoding RNA in the INK4 locus (ANRIL), was recently shown. 21828241 LncRNADisease
EL0289 CDKN2B-AS1 PRC1 RNA-Protein binding ANRIL (i.e.antisense ncRNA in INK4 locus) has also been linked to transcriptional repression via interaction with both PRC1 and PRC2. 21831473 LncRNADisease
EL0289 CDKN2B-AS1 PRC2 RNA-Protein binding ANRIL (i.e.antisense ncRNA in INK4 locus) has also been linked to transcriptional repression via interaction with both PRC1 and PRC2. 21831473 LncRNADisease
EL0289 CDKN2B-AS1 CBX7 RNA-Protein binding ANRIL was also found to coimmunoprecipitate with CBX7, which is component of the polycomb repressive complex 1 (PRC1). 21874119 LncRNADisease
EL0289 CDKN2B-AS1 Suz12 RNA-Protein binding ANRIL was found to co-immunoprecipitate with Suz12, which is component of PRC2. 21874119 LncRNADisease
EL0289 CDKN2B-AS1 p15INK4B RNA-RNA co-expression full-length ANRIL was shown to repress p15INK4B expression. Induction of p15INK4B and p16INK4A by oncogenic Ras was found to repress ANRIL expression. 21874119 LncRNADisease
EL0289 CDKN2B-AS1 p16INK4A RNA-RNA co-expression induction of p15INK4B and p16INK4A by oncogenic Ras was found to repress ANRIL expression. 21874119 LncRNADisease
EL0289 CDKN2B-AS1 PRC1 RNA-Protein binding Work over the past few years has demonstrated a direct interaction between ANRIL and components from both PRC1 and PRC2 complexes. Binding to ANRIL contributes to the functions of both PRC1 and PRC2 proteins, and disruption of either interaction impacts transcriptional repression of the target INK4b locus. 21925379 LncRNADisease
EL0289 CDKN2B-AS1 PRC2 RNA-Protein binding Work over the past few years has demonstrated a direct interaction between ANRIL and components from both PRC1 and PRC2 complexes. Binding to ANRIL contributes to the functions of both PRC1 and PRC2 proteins, and disruption of either interaction impacts transcriptional repression of the target INK4b locus. 21925379 LncRNADisease
EL0289 CDKN2B-AS1 Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
EL0289 CDKN2B-AS1 KLF2 and P21 RNA-DNA regulation we uncover that ANRIL could not repress p15 expression in PC9 cells, but through silencing of KLF2 and P21 transcription. 25504755
EL0289 CDKN2B-AS1 MET and MMP3 RNA-DNA regulation we found that MET and MMP3 are key downstream genes of ANRIL involved in SOC cell migration/invasion. 25845387
EL0289 CDKN2B-AS1 KLF2 RNA-DNA binding We also found that ANRIL could epigenetically repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to the KLF2 promoter region. 25966845
EL0289 CDKN2B-AS1 p15 RNA-DNA regulation Depletion of ANRIL increased p15 expression, with no impact on p16 or ARF (alternative reading frame) expression, and caused cell-cycle arrest at the G2/M phase, leading to inhibition of proliferation of H1299 and HeLa cells. 26408699
EL0289 CDKN2B-AS1 Bcl-2, Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP RNA-Protein regulation Knockdown of ANRIL repressed cell proliferation and increased cell apoptosis, along with decreased expression of Bcl-2 and increased expressions of Bax, cytoplasmic cytochrome c and Smac and cleaved caspase-9, caspase-3 and PARP. 26449463
EL0289 CDKN2B-AS1 p15/CDKN2Bp16/CDKN2A-p14/ARF RNA-Protein regulation These data demonstrate a complex pattern of interactions between lncRNA ANRIL, several miRNAs, PRC2/PRC1 subunits, and p15/CDKN2B-p16/CDKN2A-p14/ARF locus and suggest that their expression should be considered together to evaluate antitumoral drugs, in particular the BET bromodomain inhibitors. 27102007
EL0289 CDKN2B-AS1 MDR1 and MRP1 RNA-Protein co-expression The expression of ANRIL positively correlated with the expression of MDR1 and MRP1, resprectively 27121324
EL0290 CDR1-AS miR-7 RNA-RNA co-expression ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. Although the circRNA is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. In the mouse brain, we observe overlapping co-expression of ciRS-7 and miR-7, particularly in neocortical and hippocampal neurons, suggesting a high degree of endogenous interaction. 23446346
EL0293 ceruloplasmin STAT1 and RNA polymerase II RNA-Protein binding We identified NRCP as an intermediate binding partner between STAT1 and RNA polymerase II, leading to increased expression of downstream target genes such as glucose-6-phosphate isomerase. 26686630
EL0297 cis-NATPHO1;2 PHO1;2 RNA-RNA regulation An unexpected role for cis-NATPHO1;2 in promoting PHO1;2 translation and affecting phosphate homeostasis and plant fitness 24096344 PLNlncRbase
EL0299 COLDAIR PRC2 RNA-Protein binding COLDAIR physically associates with a component of PRC2 and targets PRC2 to FLC. 21127216 PLNlncRbase
EL0300 COOLAIR AtNDX DNA-Protein binding AtNDX associates with single-stranded DNA rather than double-stranded DNA non-sequence-specifically in vitro, and localizes to a heterochromatic region in the COOLAIR promoter in vivo. Single-stranded DNA was detected in vivo as part of an RNA-DNA hybrid, or R-loop, that covers the COOLAIR promoter. R-loop stabilization mediated by AtNDX inhibits COOLAIR transcription, which in turn modifies FLC expression. 23641115
EL0300 COOLAIR FLOWERING LOCUS C (FLC) RNA-DNA regulation Alternative polyadenylation of COOLAIR transcripts correlates with different FLC sense expression states. 24799695
EL0300 COOLAIR cyclin-dependent kinase C (CDKC;2) RNA-Protein regulation In the endogenous gene context, however, the reduction of COOLAIR transcription by cdkc;2 disrupts a COOLAIR-mediated repression mechanism that increases FLC expression. This disruption then feeds back to indirectly increase COOLAIR expression. 24799695
EL0301 CPS1-IT1 CPS1 RNA-Protein co-expression CPS1 and CPS1‑IT1 were co‑upregulated in ICC tissues compared with non‑cancerous tissues. 26499888
EL0304 CRG CASK RNA-DNA regulation CRG was required for the recruitment of RNA polymerase II to the CASK promoter regions , which in turn enhanced CASK expression. 23074190
EL0306 Crxos Crx RNA-DNA regulation We overexpressed another nat, crxos, in mouse adult retina using adeno-associated viral vectors and we observed a significant decrease in the expression levels of the corresponding sense gene, crx. 15703187
EL0309 CTB-89H12.4 PTEN RNA-DNA regulation The tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. 26975529
EL0310 CTBP1-AS PSF RNA-Protein binding Binding of mouse VL30 (A130040M12Rik) retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. 23644382
EL0311 CTD-3080P12.3 miR-1207-5p RNA-RNA binding BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. 26549025
EL0319 CX3CL1 interferon-gamma receptor gene (IFN-gamma R) DNA-DNA co-expression Their proximity and shared expression pattern suggest a possible functional relationship. 9027504
EL0321 CYP4A22-AS1 TAL1 RNA-RNA co-expression Depletion of ncRNA-a3 resulted in a specific and potent reduction of TAL1 expression. 20887892 LncRNADisease
EL0321 CYP4A22-AS1 CYP4A11 RNA-RNA co-expression When ncRNA-a3 was depleted, a significant reduction in CYP4A11 gene on the opposite strand of the DNA was detected. 20887892 LncRNADisease
EL0321 CYP4A22-AS1 ROCK2 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. 21502407 LncRNADisease
EL0325 CYTOR EGFR RNA-Protein binding Linc00152 could directly bind with EGFR which caused an activation of PI3K/AKT signaling. 26538117
EL0325 CYTOR EpCAM RNA-DNA binding LINC00152 could activate the mechanistic target of rapamycin(mTOR) pathway by binding to the promoter of EpCAM through a cis-regulation, as confirmed by Gal4-λN/BoxB reporter system. 26540343
EL0326 Dab2 Dab2 RNA-RNA co-expression The expression profiles of Dab2 and the intronic ncRNA were correlated (R2 = 0.77), suggesting some relationship in their function and/or regulation. 18562676 LncRNADisease
EL0327 DACOR1 Cystathionine β-synthase RNA-Protein regulation DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. 26307088
EL0328 Dalir DNMT1 DNA methyltransferase i RNA-Protein binding Dali interacts with the DNMT1 DNA methyltransferase in mouse and human and regulates DNA methylation status of CpG island-associated promoters in trans. 25415054
EL0329 DANCR CTNNB1 RNA-DNA regulation Association of DANCR with CTNNB1 blocked the repressing effect of microRNA (miR)-214, miR-320a, and miR-199a on CTNNB1. 25964079
EL0329 DANCR Sox4 DNA-Protein binding Sox4 could directly bind to the promoter of long noncoding RNA DANCR and increased its expression. Knockdown of DANCR could reverse the stimulative effect of Sox4 on the proliferation and chondrogenesis of SMSCs. 26514989
EL0329 DANCR DSPP and DMP-1, p-GSK-3β and β-catenin RNA-Protein regulation lncRNA DANCR overexpression blocked mineralized nodule formation and the expression of DSPP and DMP-1 in hDPCs after 14 days of odontogenic induction. Importantly, the upregulation of DANCR significantly decreased the expression levels of p-GSK-3β and β-catenin expression indicating that lncRNA DANCR can inhibit the activation of the Wnt/β-catenin signal pathway during the odontoblast-like differentiation of hDPCs. 26646542
EL0332 DBET Ash1L RNA-Protein regulation DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. 22541069
EL0333 DBH-AS1 hepatitis B virus x protein (HBx) RNA-Protein regulation DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. 26393879
EL0333 DBH-AS1 p53 RNA-Protein regulation DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. 26393879
EL0333 DBH-AS1 MAPK signaling N/A regulation DBH-AS1 was shown to activate MAPK pathway. 26393879
EL0333 DBH-AS1 CDK6, CCND1, CCNE1 RNA-Protein regulation Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. 26393879
EL0333 DBH-AS1 p16, p21 and p27 RNA-Protein regulation Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. 26393879
EL0336 DGCR5 REST DNA-TF regulation The DiGeorge syndrome-associated noncoding RNA, DGCR5, is repressed by REST through a proximal upstream binding site. 19050060 LncRNADisease
EL0337 DHFR upstream transcripts DHFR RNA-DNA regulation Regulates DHFR expression by forming a of triple helix with the DHFR major promoter and interacting with TFIIB. 21256239 LncRNADisease
EL0337 DHFR upstream transcripts TFIIB RNA-Protein binding Regulates DHFR expression by forming a of triple helix with the DHFR major promoter and interacting with TFIIB. 21256239 LncRNADisease
EL0338 DHRS4-AS1 H3K9- and H3K27-specific histone methyltransferases G9a and EZH2 RNA-DNA regulation AS1DHRS4 interacts physically in trans with the epigenetic modifiers H3K9- and H3K27-specific histone methyltransferases G9a and EZH2 22891334
EL0343 DLEU1 ESR1 RNA-Protein co-expression A statistical analysis revealed that there was a co-expression relationship between ESR1 and lncRNA-DLEU1. 26416600
EL0343 DLEU1 MiR-19a RNA-RNA co-expression MiR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1, which influences the occurrence and development of breast cancer cells with different levels of ER expression. 26416600
EL0344 DLEU2 trichostatin A (TSA) RNA-Protein regulation TSA and SB increase the expression of Dleu2, miR-15a, and miR-16-1 in lung cancer cells. 23867991
EL0344 DLEU2 BSAP DNA-Protein regulation transcription factor BSAP (B-cell-specific activator protein) directly interacts with Dleu2, the host gene containing the miR-15a/16-1 loci, and by negative regulation of the Dleu2 promoter, results in repression of miR-15a/16-1 expression. BSAP directly interacts with the Dleu2 promoter. 23995789
EL0345 Dleu2 Trim13 RNA-RNA co-expression A study found that Dleu2, a previously described ncRNA overlapping but transcribed in the opposite direction of the Trim13 (RFP2/LEU5) gene whose expression is upregulated during early OL maturation and terminal differentiation. 20137068 LncRNADisease
EL0347 Dlx1as Dlx RNA-RNA co-expression Evf2, Dlx1as, and Dlx4as exhibit similar expression profiles to the associated Dlx genes. 18562676 LncRNADisease
EL0347 Dlx1as Dlx1 RNA-RNA regulation The reciprocal relationship between Dlx1as and Dlx1 places this sense-antisense pair into a growing class of mammalian lncRNA-mRNA pairs characterized by inverse regulation. 23415800
EL0348 Dlx4os Dlx RNA-RNA co-expression Evf2, Dlx1as, and Dlx4as exhibit similar expression profiles to the associated Dlx genes. 18562676 LncRNADisease
EL0349 DLX6-AS1 Dlx-2 RNA-Protein regulation Evf-2 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. A stable complex containing the Evf-2 ncRNA and the Dlx-2 protein forms in vivo, suggesting that the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity. These experiments identify a novel mechanism whereby transcription is controlled by the cooperative actions of an ncRNA and a homeodomain protein. 16705037
EL0349 DLX6-AS1 Dlx-5 DNA-DNA regulation Evf2 is a long, polyadenylated ncRNA transcribed from an ultraconserved intergenic enhancer region associated with the Dlx-5/6 locus. 20573714 LncRNADisease
EL0349 DLX6-AS1 Dlx-6 DNA-DNA regulation Evf2 is a long, polyadenylated ncRNA transcribed from an ultraconserved intergenic enhancer region associated with the Dlx-5/6 locus. 20573714 LncRNADisease
EL0350 Dlx6os1 DLX5 RNA-DNA regulation DLX6-AS1 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. 16705037 LncRNADisease
EL0350 Dlx6os1 DLX6 RNA-DNA regulation DLX6-AS1 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. 16705037 LncRNADisease
EL0350 Dlx6os1 Dlx6 RNA-DNA regulation Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. 18184812 LncRNADisease
EL0350 Dlx6os1 Dlx2 RNA-Protein binding Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. 18184812 LncRNADisease
EL0350 Dlx6os1 Dlx6 RNA-DNA regulation Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. Consistent with this function, Evf exhibits a coincident expression profile with Dlx2. 18184812 LncRNADisease
EL0350 Dlx6os1 Dlx2 RNA-Protein binding Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. Consistent with this function, Evf exhibits a coincident expression profile with Dlx2. 18184812 LncRNADisease
EL0350 Dlx6os1 DLX2 DNA-TF regulation Evf2 regulates the binding of the DLX2 transcription factor to its originating enhancer element, which in turn regulates the transcriptional activity of the enhancer. 18562676 LncRNADisease
EL0350 Dlx6os1 Dlx2 RNA-Protein binding Single-stranded Evf2 forms a complex with the product of a third homeodomain gene Dlx2 whose sequence lies elsewhere in the mouse genome. 19239885 LncRNADisease
EL0350 Dlx6os1 Dlx2 RNA-Protein binding The 3.8-kb Evf-2 ncRNA, which is transcribed from an ultraconserved region, forms a complex with the homeodomain-containing protein Dlx2. 19571179 LncRNADisease
EL0350 Dlx6os1 Dlx6 RNA-DNA regulation Evf-2 was previously shown to regulate binding of the Dlx2 transcription factor to the ultraconserved enhancer to activate the expression of the encompassed Dlx6 gene during neurogenesis. 20137068 LncRNADisease
EL0350 Dlx6os1 Dlx2 RNA-Protein binding Evf-2 was previously shown to regulate binding of the Dlx2 transcription factor to the ultraconserved enhancer to activate the expression of the encompassed Dlx6 gene during neurogenesis. 20137068 LncRNADisease
EL0350 Dlx6os1 DLX DNA-TF regulation the lincRNA Evf2 is transcribed from an ultraconserved distal enhancer that recruits positive (i.e., DLX) and negative (i.e., MECP2) transcription factors to the enhancer to modulate the expression of adjacent protein-coding genes 20380817 LncRNADisease
EL0350 Dlx6os1 MECP2 DNA-TF regulation the lincRNA Evf2 is transcribed from an ultraconserved distal enhancer that recruits positive (i.e., DLX) and negative (i.e., MECP2) transcription factors to the enhancer to modulate the expression of adjacent protein-coding genes 20380817 LncRNADisease
EL0350 Dlx6os1 Dlx-5 RNA-DNA regulation Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
EL0350 Dlx6os1 Dlx-6 RNA-DNA regulation Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
EL0350 Dlx6os1 Dlx-2 RNA-Protein binding Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
EL0350 Dlx6os1 Dlx-5 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2, and is consequently an indirect positive regulator of Dlx-5 and Dlx-6. 20951849 LncRNADisease
EL0350 Dlx6os1 Dlx-6 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2, and is consequently an indirect positive regulator of Dlx-5 and Dlx-6. 20951849 LncRNADisease
EL0350 Dlx6os1 Dlx-2 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2. 20951849 LncRNADisease
EL0350 Dlx6os1 Dlx-5/6 enhancer RNA-DNA regulation Cooperates with Dlx-2 in vivo to increase the transcriptional activity of the Dlx-5/6 enhancer. 21256239 LncRNADisease
EL0350 Dlx6os1 Dlx-5/6 enhancer RNA-DNA regulation Cooperates with Dlx-2 in vivo to increase the transcriptional activity of the Dlx-5/6 enhancer. 21256239 LncRNADisease
EL0350 Dlx6os1 Dlx6 RNA-DNA regulation Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease
EL0350 Dlx6os1 DLX2 RNA-Protein binding Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease
EL0350 Dlx6os1 MECP2 RNA-Protein binding Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease
EL0352 Dmrt2 TERT RNA-Protein binding TERRA also contacts the telomerase reverse transcriptase (TERT) protein subunit independently of the telomerase template RNA moiety. 21925379 LncRNADisease
EL0352 Dmrt2 telomerase RNA-Protein binding TERRA has now been demonstrated to physically interact with the telomerase through a repeat sequence complementary to the template sequence of telomerase RNA. 21925379 LncRNADisease
EL0354 DNM3OS TWIST1 DNA-TF regulation Twist-1 regulates the miR-199a/214 cluster during development. 19029138 LncRNADisease
EL0359 dutA STAT RNA-DNA regulation Thought to function upstream of Dictyostelium STAT transcription factor Dd-STATa. 21256239 LncRNADisease
EL0360 E130102H24Rik Cox2 RNA-RNA co-expression AK021368 and Cox2 exhibit overlapping expression profiles in the cerebral cortex, raising the possibility that a similar regulatory mechanism occurs in the brain. 18184812 LncRNADisease
EL0361 EBER PKR RNA-Protein binding Autophosphorylation assays confirmed that both EBER(I) and VA(I) are inhibitors of PKR activation, and profiled the kinetics of the inhibition. Binding affinities of dsRNAs to PKR double-stranded RNA-binding domains (dsRBDs) were determined by isothermal titration calorimetry and gel electrophoresis. 16580685
EL0364 EGFLAM-AS1 LIFR RNA-RNA regulation lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level. LIFR gene is up-regulated by lncRNA-LOWEG. 26537802
EL0365 EGFR-AS1 GHR RNA-DNA regulation Impeded expression of GHR decreased the expression of EGFR and EGFR-AS1 in vivo and in vitro. 26271667
EL0369 EMX2OS EMX2 RNA-RNA co-expression Emx2, emx2os, emx2, and emx2os are abundant in the uterine endometrium, with sense and antisense transcripts exhibiting identical expression patterns. 12573261
EL0369 EMX2OS EMX2 RNA-RNA regulation EMX2OS post-transcriptionally regulates the abundance of the coding transcript, thereby regulating activity of EMX2. 21128942 LncRNADisease
EL0370 Emx2os Emx2 RNA-RNA co-expression Emx2, emx2os, emx2, and emx2os are abundant in the uterine endometrium, with sense and antisense transcripts exhibiting identical expression patterns. 12573261
EL0376 ENOD40 MtRBP1 RNA-Protein binding A novel rna binding protein interacting with the enod40 rna, mtrbp1 (for medicago truncatula rna binding protein 1), was identified using a yeast three-hybrid screening. 15037734
EL0387 enod40 MtRBP1 (Medicago truncatula RNA Binding Protein 1) RNA-Protein binding Direct involvement of the enod40 RNA in MtRBP1 relocalization into cytoplasmic granules was shown using a transient expression assay. 15037734 PLNlncRbase
EL0449 ENST00000414355 DNA-damage related genes (ATM, ATR and ATRIP) RNA-DNA regulation SiRNA-mediated knockdown of ENST00000414355 inhibited the growth of DNA-damaged cells and decreased the expressions of DNA-damage related genes (ATM, ATR and ATRIP), while increased the expressions of DNA-repair related genes (DDB1, DDB2, OGG1, ERCC1, MSH2, RAD50, XRCC1 and BARD1). 26464647
EL0449 ENST00000414355 DNA-repair related genes (DDB1, DDB2, OGG1, ERCC1, MSH2, RAD50, XRCC1 and BARD1) RNA-DNA regulation SiRNA-mediated knockdown of ENST00000414355 inhibited the growth of DNA-damaged cells and decreased the expressions of DNA-damage related genes (ATM, ATR and ATRIP), while increased the expressions of DNA-repair related genes (DDB1, DDB2, OGG1, ERCC2, MSH' 26464647
EL0479 ERICD E2F DNA-Protein regulation expression levels of ERIC were elevated upon activation of exogenous E2F1, E2F3 or endogenous E2Fs. knockdown of either E2F1 or E2F3 reduced ERIC levels and endogenous E2F1 binds ERIC's promoter. Expression of ERIC was cell cycle regulated and peaked in G1 in an E2F1-dependent manner. Inhibition of ERIC expression increased E2F1-mediated apoptosis, suggesting that E2F1 and ERIC constitute a negative feedback loop that modulates E2F1 activity. Furthermore, ERIC levels were increased following DNA damage by the chemotherapeutic drug Etoposide, and inhibition of ERIC expression enhanced Etoposide -induced apoptosis. 24168400
EL0484 EWSAT1 heterogeneous nuclear ribonucleoprotein (HNRNPK) RNA-Protein binding heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 25401475
EL0486 FALEC ECM1 RNA-RNA co-expression Depletion of ncRNA-a1 (activating long ncRNA 1, LINC00568), results in decreased ECM1 levels, suggesting a direct activating function of ncRNA-a1 on its neighboring gene. 21502407 LncRNADisease
EL0486 FALEC BMI1 RNA-DNA regulation FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. 25203321
EL0486 FALEC p21 RNA-DNA regulation The oncogenic activity of FAL1 is partially attributable to its repression of p21. 25203321
EL0486 FALEC BMI1 RNA-Protein regulation The oncogenic activity of FAL1 was mediated in part by its interaction with BMI1, a component of the chromatin-modifying Polycomb repressive complex 1, which resulted in increased stabilization of BMI1 protein and transcriptional repression of genes involved in processes such as cell proliferation and apoptosis. 25367941
EL0487 FAM30A β-Catenin RNA-Protein regulation The expression of β-Catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. 26448925
EL0491 FAS-AS1 Fas RNA-RNA regulation Saf might regulate the expression of Fas alternative splice forms through pre-mRNA processing. 15829500 LncRNADisease
EL0491 FAS-AS1 Fas RNA-RNA regulation Saf might regulate the expression of fas alternative splice forms through pre-mrna processing. 15829500
EL0492 FENDRR PRC2 RNA-Protein binding Numerous lincRNAs are physically associated with PRC2. 19571010 LncRNADisease
EL0492 FENDRR FN1 and MMP2/MMP9 RNA-Protein regulation FENDER overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression. 25167886
EL0494 FER1L4 miR-106a-5p RNA-RNA regulation Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. 26306906
EL0494 FER1L4 PTEN RNA-RNA regulation lncRNA FER1L4 (fer-1-like family member 4, pseudogene) acts as a competing endogenous RNA (ceRNA) to regulate the expression of PTEN (a well-known tumor suppressor gene) by taking up miR-106a-5p in gastric cancer. 26306906
EL0503 FLC histone H3Lys4 RNA-Protein regulation The degradation of FRI (FRIGIDA) is accompanied by an increase in the levels of the long noncoding RNA ColdAIR, which reduces the level of histone H3Lys4 trimethylation (H3K4me3) in FLOWERING LOCUS C chromatin to promote flowering. 25538183
EL0508 FOXC2-AS1 ABCB1 RNA-DNA regulation The expression of classical drug resistance-related ATP-binding cassette, subfamily B, member 1 (ABCB1) gene was decreased after the lncRNA ODRUL knockdown. 26408180
EL0509 FOXCUT FOXC1 RNA-RNA regulation FOXCUT and FOXC1 may function as a lncRNA-RNA gene pair, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients. 25031703
EL0509 FOXCUT FOXC1 RNA-DNA regulation The results showed that the expression of FOXCUT and FOXC1 were positively correlated 25516208
EL0512 FRLnc1 FOXM1 RNA-DNA co-expression FRLnc1 expression is positively correlated with FOXM1 level. 25907137
EL0514 FTX Xist RNA-RNA regulation The Ftx mutation, however, results in widespread alteration of transcript levels within the X-inactivation center (Xic) and particularly important decreases in Xist RNA levels. 21118898
EL0514 FTX RIG-I RNA-Protein regulation Ectopic expression of RIG-I abrogated the effects of lncRNA Ftx or miR-545 on HCC cells. LncRNA Ftx/miR-545-mediated downregulation of RIG-I led to increased Akt phosphorylation in vitro and in vivo. 26992218
EL0514 FTX miR-545 , RIG-I RNA-RNA co-expression MiR-545 was positively correlated with lncRNA Ftx expression. 26992218
EL0514 FTX PI3K/Akt signaling N/A regulation The novel pathway lncRNA Ftx/miR-545/RIG-I promotes HCC development by activating PI3K/Akt signaling. 26992218
EL0515 Ftx XIST RNA-DNA regulation Ftx has both a global role in the adjustment of the transcription levels of several genes in the Xic and a positive effect on Xist expression that coincides with a role in preventing the methylation of the Xist promoter. 21329697 LncRNADisease
EL0515 Ftx XIST RNA-RNA co-expression Ftx is upregulated specifically in female cells at the time of Xist upregulation and X inactivation. 21496640 LncRNADisease
EL0516 G22 PABP RNA-Protein binding Binds PABP and the SRP9/14 heterodimer. 21256239 LncRNADisease
EL0516 G22 SRP9/14 heterodimer RNA-Protein binding Binds PABP and the SRP9/14 heterodimer. 21256239 LncRNADisease
EL0522 GAL10 H3 RNA-Protein regulation Cryptic ncRNA transcription can direct H3 K36me3 formation over repressed genes and intergenic regions, which otherwise lack this histone modification. 19061643 LncRNADisease
EL0522 GAL10 Reb1 RNA-Protein regulation Reb1-driven ncRNA transcription causes reduced acetylation of specific histone residues over the GAL1 and GAL10 coding regions. 19061643 LncRNADisease
EL0522 GAL10 TRAMP complexes RNA-Protein regulation The GAL10-ncRNA is targeted for degradation by the TRAMP complexes. 19061643 LncRNADisease
EL0522 GAL10 Reb1 DNA-TF regulation Transcription of GAL10-ncRNA is driven by the DNA-binding protein Reb1. 19061643 LncRNADisease
EL0522 GAL10 RAT1 RNA-RNA co-expression The importance of RAT1 was reinforced by the finding that GAL10 lncRNA was more functionally compromised by loss of RAT1 than XRN1. 22325347 LncRNADisease
EL0524 GAS1RR Shh-GLI1 RNA-Protein regulation The Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). 26418365
EL0526 GAS5 NR3C1 RNA-Protein binding Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Gas5 bound to the DNA-binding domain of the glucocorticoid receptor (GR) by acting as a decoy glucocorticoid response element (GRE), thus competing with DNA GREs for binding to the GR. 20124551 LncRNADisease
EL0526 GAS5 NR3C1 RNA-Protein regulation The multifunctional GAS5 lncRNA is a negative regulator of the glucocorticoid receptor and other nuclear receptors. 20951849 LncRNADisease
EL0526 GAS5 miR-21 RNA-RNA regulation miR-21 is capable of suppressing the lncRNA growth arrest-specific 5 (GAS5). GAS5 can also repress miR-21 expression. 23933812
EL0526 GAS5 Annexin A2 RNA-Protein binding RNA pull-down experiment revealed a direct bind of lncRNA-GAS5 to a Ca2+-dependent RNA-binding protein, Annexin A2. 25806802
EL0526 GAS5 IGF-1R RNA-DNA regulation GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins. 25925741
EL0526 GAS5 Y-box binding protein 1 (YBX1) RNA-Protein binding lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1), and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription. 25959498
EL0526 GAS5 Plexin C1 RNA-Protein regulation The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. 26364613
EL0526 GAS5 tumor suppressor Bcl-2-modifying factor (bmf) RNA-Protein regulation The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. 26364613
EL0526 GAS5 miR-21 RNA-RNA regulation Thus, GAS5 acts as a tumor suppressor in HCCs through negative regulation of miR-21 and its targets and proteins about migration and invasion in cancer cells. 26404135
EL0526 GAS5 miR-222 RNA-RNA binding A pulldown assay further validated that GAS5 could directly bind to miR-222. 26446789
EL0526 GAS5 BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 RNA-Protein regulation GAS5 could disrupt mitochondrial membrane potential and promote BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 expression. 26503132
EL0526 GAS5 miR-103 RNA-RNA regulation Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis. 26511107
EL0526 GAS5 Ki67 RNA-Protein regulation Lower GAS5 levels appeared in the patients with a high Ki67 proliferation index before surgery 26662314
EL0526 GAS5 vimentin RNA-Protein regulation GAS5 negatively regulates vimentin expression in vitro and in vivo. Notably, vimentin knockdown promoted GAS5‑pcDNA3.1‑inhibition of hepatoma cell proliferation. 26707238
EL0526 GAS5 MMP2 RNA-Protein regulation Overexpressing lncRNA GAS5 inhibited the migration and invasion ability of melanoma SK-Mel‑110 cells, partially by decreasing the MMP2 expression and its activity. 26846479
EL0526 GAS5 phosphatase and tensin homologs (PTEN) RNA-Protein regulation GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21. 27034004
EL0526 GAS5 miR-21 RNA-RNA binding GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21. 27034004
EL0532 Gfra1 Gfra1 RNA-DNA regulation LncRNA033862 is an antisense transcript of the GDNF receptor alpha1 (Gfra1) that lacks protein coding potential and regulates Gfra1 expression levels by interacting with Gfra1 chromatin. 26962690
EL0535 Gli3 Gli3 RNA-RNA co-expression The downregulation of a ncRNA (AK053922) is associated with the Gli3 locus in all progeny of N/OPs, whereas Gli3 was upregulated in N/OPs but downregulated in all progeny of N/Ops. 20137068 LncRNADisease
EL0538 Gm15577 Negr1, Shh and β-catenin RNA-DNA regulation Gm15577 modulated the RNA expression of Negr1, Shh and β-catenin. Gm15577 may modulate cerebellar granule cell proliferation and differentiation by targeting Negr1, and their dysfunctions or abnormal expression may be related to tumorigenesis of medulloblastoma. 26705043
EL0539 Gm16845 Ecsit RNA-RNA co-expression A cisantisense ncRNA (GenBank accession no. AK154427) exhibits a negative expression correlation (R2= -0.92) with its sense protein-coding gene Ecsit. 18562676 LncRNADisease
EL0541 Gm30731 PTBP1 RNA-Protein binding Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. 25800779
EL0552 GSTT1-AS1 zeste homolog 2 (EZH2) RNA-Protein binding By recruiting polycomb protein enhancer of zeste homolog 2 (EZH2) to infg/tnfa promoters, lncRNA-CD244 mediates H3K27 trimethylation at infg/tnfa loci toward repressive chromatin states and inhibits IFN-γ/TNF-α expression in CD8(+) T cells 26150504
EL0555 H19 Igf2 of imprinted gene network (IGN) RNA-Protein regulation We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene network (IGN) was performed in both loss- and gain-of-function animals. We found that H19 deletion leads to the upregulation of several genes of the IGN. 19762426
EL0555 H19 let-7 RNA-RNA binding Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. 25399420
EL0555 H19 Igf2 (insulin-like growth factor 2) RNA-DNA regulation This is associated with the disruption of igf2 imprinting and the consequent biallelic expression of this gene. 9203585
EL0556 H19 SERPINE1 RNA-RNA co-expression Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal. 10738131
EL0556 H19 IMP RNA-Protein binding Human h19 rna contains four attachment sites for the oncofetal igf-ii mrna-binding protein (imp) 10875929
EL0556 H19 IMP-3 RNA-Protein regulation Imp-3 protein associates with igf-ii leader-3 and leader-4 mrnas and h19 rna 15753088
EL0556 H19 miR-675 RNA-RNA co-expression Recently, it was found that the H19 RNA is host to an exonic microRNA, miR-675, which, as a result, is also imprinted and maternally expressed. 19239885 LncRNADisease
EL0556 H19 c-myc DNA-TF regulation H19 has been linked to the oncogene, c-myc, which positively regulates its expression in diverse cell types including T98G human glioblastoma cells. 20380817 LncRNADisease
EL0556 H19 p53 DNA-TF regulation H19 has been linked to the tumor suppressor, p53, which negatively regulates its expression. 20380817 LncRNADisease
EL0556 H19 GLI1 DNA-TF regulation H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas. 20380817 LncRNADisease
EL0556 H19 SHH DNA-TF regulation H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas. 20380817 LncRNADisease
EL0556 H19 E2F1 RNA-Protein regulation H19 transcription is positively regulated by the cell cycle regulatory factor, E2F1, during the S-phase of growth-stimulated cells. 20380817 LncRNADisease
EL0556 H19 Igf2 RNA-RNA co-expression Complex functions, influences growth by down-regulating a number of imprinted genes including Igf2, also implicated as both a tumour suppressor and an oncogene. 21256239 LncRNADisease
EL0556 H19 CTCF1 RNA-RNA co-expression Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p? 22395465 LncRNADisease
EL0556 H19 CTCF2 RNA-RNA co-expression Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p<=0.05). 22395465 LncRNADisease
EL0556 H19 CTCF3 RNA-RNA co-expression There is a CTCF-binding site (CTCF3) in the imprinting control region (ICR) upstream of H19. 22395465 LncRNADisease
EL0556 H19 IGF2 RNA-Protein regulation H19 is an imprinted maternally expressed gene influencing IGF2 expression, whose transcript is a long noncoding (lnc) RNA of unknown biological function harboring the miR-675. 22527881
EL0556 H19 H19 transcript can counteract 91H-mediated Igf2 activation RNA-RNA regulation A large excess of the H19 transcript can counteract 91H-mediated Igf2 activation. 22662250
EL0556 H19 Igf2 RNA-Protein regulation Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans 22662250
EL0556 H19 let-7 family of microRNAs RNA-RNA binding Vertebrate H19 harbors both canonical and noncanonical binding sites for the let-7 family of microRNAs, which plays important roles in development, cancer, and metabolism. 24055342
EL0556 H19 H1.3 RNA-Protein regulation H1.3dramatically inhibits H19 expression, which contributes to the suppression of epithelial ovarian carcinogenesis. 25205099
EL0556 H19 K homology-type splicing regulatory protein (KSRP) RNA-Protein binding KSRP directly binds to H19 in the cytoplasm of undifferentiated multipotent mesenchymal C2C12 cells 25385579
EL0556 H19 miR-138 and miR-200a RNA-RNA regulation by using bioinformatics study and RNA immunoprecipitation combined with luciferase reporter assays, we demonstrated that H19 functioned as a competing endogenous RNA (ceRNA) for miR-138 and miR-200a, antagonized their functions and led to the de-repression of their endogenous targets Vimentin, ZEB1, and ZEB2, all of which were core marker genes for mesenchymal cells 26068968
EL0556 H19 MiR-141 RNA-RNA binding MiR-141 binds to H19 in a sequence specific manner, and suppresses H19 expression and functions including proliferation and invasion. MiR-141 could also regulate H19 target genes and miR-141 inhibitor restores H19 siRNA function, while H19 regulates miR-141 target gene ZEB1. 26160158
EL0556 H19 Yes-associated protein 1 (YAP1) RNA-Protein co-expression H19 expression was found to be significantly associated with YAP1 expression. H19, at least in part, is induced by YAP1 overexpression. 26163939
EL0556 H19 miR-675 RNA-RNA regulation Ectopic expression of H19 significantly increased bladder cancer cell proliferation and miR-675 expression in vitro. 26198047
EL0556 H19 histone deacetylase (HDAC) 4/5 RNA-DNA regulation H19/miR-675 downregulated the mRNA and protein levels of histone deacetylase (HDAC) 4/5, and thus increased osteoblast marker gene expression. 26417995
EL0556 H19 transforming growth factor-β1 (TGF-β1) RNA-DNA regulation H19/miR-675 inhibited mRNA and protein expression of transforming growth factor-β1 (TGF-β1). 26417995
EL0556 H19 c-Myc RNA-Protein regulation H19 was a direct transcriptional target of c-Myc. 26482621
EL0556 H19 S-adenosylhomocysteine hydrolase (SAHH) RNA-Protein binding The developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH) 26687445
EL0556 H19 c-Myc DNA-DNA regulation The activity of the promoter of H19 was strengthened by c-Myc. 26722426
EL0556 H19 miR-107 RNA-RNA regulation The expression of miR-107 increased or decreased with the overexpression and knockdown of H19, respectively. The number of cells in G2/M stage decreased significantly with the knockdown of H19 and miR-107 compared with the control group. 26722426
EL0556 H19 heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin RNA-Protein regulation H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression. 26801864
EL0556 H19 AKT2 RNA-RNA co-expression The RNA levels of H19 and AKT2 were positively correlated. 26803515
EL0556 H19 miR-141 and miR-22 RNA-RNA binding H19 functioned as an miRNA sponge for miR-141 and miR-22, both of which were negative regulators of osteogenesis and Wnt/β-catenin pathway. 26853553
EL0556 H19 HuR RNA-Protein regulation H19 interacts with HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675 by altering ZO-1 and E-cadherin expression posttranscriptionally. 26884465
EL0556 H19 miR-675 RNA-RNA regulation H19 plays an important role in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA 675 (miR-675). H19 overexpression increased the cellular abundance of miR-675, which in turn destabilized and repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfunction of the epithelial barrier. 26884465
EL0556 H19 RUNX1 RNA-DNA regulation Overexpression of H19 or miR-675 significantly decreased RUNX1 expression in AGS cells, and knockdown of H19 or miR-675 enhanced RUNX1 expression. 26931432
EL0556 H19 miR-675 RNA-RNA regulation The expression of miR-675 was positively correlated with H19 in patients with gastric cancer. 26931432
EL0556 H19 eIF4A3 RNA-Protein binding eIF4A3 as an RNA-binding protein that binds to H19. Combining eIF4A3 with H19 obstructed the recruitment of eIF4A3 to the cell-cycle gene mRNA. 26989025
EL0556 H19 EZH2 RNA-DNA regulation H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner. 27040767
EL0556 H19 miR-630 RNA-RNA regulation H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner. 27040767
EL0556 H19 CaMKIIδ RNA-Protein regulation CaMKIIδ was a direct target of miR-675 and partially mediated the effect of H19 on cardiomyocyte hypertrophy. 27084844
EL0556 H19 miR-675 RNA-RNA regulation H19 encoded miR-675. 27084844
EL0560 Halr1 Hoxa1 RNA-DNA regulation linc-HOXA1 RNA represses Hoxa1 by recruiting the protein PURB as a transcriptional cofactor. 23723417
EL0560 Halr1 PURB RNA-Protein regulation linc-HOXA1 RNA represses Hoxa1 by recruiting the protein PURB as a transcriptional cofactor. 23723417
EL0561 HAR1A RELN DNA-TF regulation The lncRNA HAR1F is transcribed from one of these regions and specifically co-expressed in Cajal-Retzius cells of the human neocortex with the critical neural factor RELN (Pollard et al., 2006), which mediates seminal neural developmental processes and is implicated in the pathophysiology of a broad range of neurological and psychiatric disorders. 20380817 LncRNADisease
EL0561 HAR1A REST DNA-TF regulation RNA in-situ hybridization showed that HAR1F is expressed in developing neurons of the human embryonic neocortex, and its expression was recently shown to be regulated by the master neural transcriptional repressor, REST. 20951849 LncRNADisease
EL0563 HBB Dicer RNA-Protein regulation Intergenic transcripts of the beta-globin gene cluster are specifically upregulated in dicer-deficient cells. 16227618
EL0565 HEIH EZH2 RNA-Protein binding It was shown that lncRNAHEIH associates with EZH2 and that this association is required for the expression of EZH2-regulated target genes. 21769904 LncRNADisease
EL0569 HIF1A-AS1 HOXD10 RNA-DNA regulation Low expression of HIF1α‑AS1 was sufficient to block the expression of HOXD10. Downregulation of HOXD10 by HIF1α‑AS1 interfered with acetylation, and subsequently resulted in the inhibition of osteoblast differentiation. 26460121
EL0571 HIF2PUT HIF‑2α RNA-RNA regulation the lncRNA HIF2PUT may be a novel regulatory factor of osteosarcoma stem cells, which may exert its function partly by controlling HIF‑2α expression. 25434862
EL0571 HIF2PUT HIF-2α RNA-Protein regulation Knockdown of lncRNA-HIF2PUT blocked the HIF-2α expression and inhibited the CSC properties in CRC cell lines DLD-1 and HT29. 26648739
EL0574 Hm629797 Pc4, hnRNP A/B and hnRNP A2/B1 RNA-Protein binding We also identified interacting proteins of mrhl RNA associated chromatin fraction which included Pc4, a chromatin organizer protein and hnRNP A/B and hnRNP A2/B1 which have been shown to be associated with lincRNA-Cox2 function in gene regulation. 25584904
EL0575 HNF1A-AS1 cyclin D1, E-cadherin, N-cadherin and β-catenin RNA-Protein regulation HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and β-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. 25863539
EL0575 HNF1A-AS1 CEA, CA19-9, RRM1 RNA-Protein regulation Low HNF1A-AS1 expression was associated with tumor size/diameter (p = 0.005, multivariate analysis), levels of serum carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), and RRM1 expression in tissue samples (p = 0.028, p = 0.009, and p = 0.006, respectively). 26472090
EL0575 HNF1A-AS1 Bcl-2 RNA-Protein regulation HNF1A-AS1 functioned as an oncogene in tumor growth and apoptosis through sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2. 27084450
EL0575 HNF1A-AS1 miR-30b RNA-RNA binding HNF1A-AS1 functioned as an oncogene in tumor growth and apoptosis through sponging tumor-suppressive hsa-miR-30b-5p (miR-30b) and de-repressing Bcl-2. 27084450
EL0576 Hog Hoxd DNA-DNA binding The start site of two opposite long noncoding RNAs (lncRNAs), Hotdog and Twin of Hotdog, selectively contacts the expressed Hoxd genes in the framework of a topological domain, coinciding with robust transcription of these genes during cecum budding. 24075990
EL0578 HOTAIR HOXD RNA-DNA regulation HOTAIR is transcribed at the intersection of opposing chromatin domains in the HOXC locus, but targets Polycomb Repressive Complex 2 (PRC2) to represses transcription in trans across 40 kilobases of the HOXD locus. 17604720 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding HOTAIR is transcribed at the intersection of opposing chromatin domains in the HOXC locus, but targets Polycomb Repressive Complex 2 (PRC2) to silence 40 kilobases of HOXD. 17604720 LncRNADisease
EL0578 HOTAIR HOXD RNA-DNA regulation HOTAIR represses transcription in trans across 40 kilobases of the HOXD locus. 17604720 LncRNADisease
EL0578 HOTAIR HOXD locus,Polycomb Repressive Complex 2 (PRC2) RNA-Protein regulation HOTAIR, which represses transcription in trans across 40 kilobases of the HOXD locus. HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus. 17604720
EL0578 HOTAIR HOXD RNA-DNA regulation HOTAIR represses the expression in trans of genes in the HOXD cluster. Depletion of HOTAIR by siRNA resulted in the activation of HOXD genes in trans. 19015002 LncRNADisease
EL0578 HOTAIR Ezh2 RNA-Protein binding HOTAIR RNA plays a critical role in establishing H3K27me3 enriched chromosomal domains through interaction with PRC2 complex members such as Suz12 and Ezh2. 19015002 LncRNADisease
EL0578 HOTAIR Suz12 RNA-Protein binding HOTAIR RNA plays a critical role in establishing H3K27me3 enriched chromosomal domains through interaction with PRC2 complex members such as Suz12 and Ezh2. 19015002 LncRNADisease
EL0578 HOTAIR HOXD RNA-RNA co-expression HOTAIR showed negative association with HOXD genes. 19182780 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding HOTAIR coprecipitated with PRC2 in both HeLa and hFFs, but not in hLFs. 19571010 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation. 20393566 LncRNADisease
EL0578 HOTAIR H3 RNA-Protein regulation HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation. 20393566 LncRNADisease
EL0578 HOTAIR H3 RNA-Protein regulation HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation. 20393566 LncRNADisease
EL0578 HOTAIR LSD1 RNA-Protein binding A 3' domain of HOTAIR binds the LSD1/CoREST/REST complex. 20616235 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding A 5'domain of HOTAIR binds polycomb repressive complex 2 (PRC2). 20616235 LncRNADisease
EL0578 HOTAIR LSD1 RNA-Protein binding Immunoprecipitation (IP) of LSD1 retrieved endogenous HOTAIR with comparable enrichment to that of PRC2 IP. It was hypothesized that HOTAIR may also bind the LSD1-CoREST complex. 20616235 LncRNADisease
EL0578 HOTAIR HOXD RNA-DNA regulation The lincRNA HOTAIR is transcribed from the HOXC locus and targets Polycomb Repressive Complex 2 (PRC2, comprised of H3K27 methylase EZH2, SUZ12, and EED) to silence HOXD and select genes on other chromosomes. 20616235 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding The lincRNA HOTAIR is transcribed from the HOXC locus and targets Polycomb Repressive Complex 2 (PRC2, comprised of H3K27 methylase EZH2, SUZ12, and EED) to silence HOXD and select genes on other chromosomes. 20616235 LncRNADisease
EL0578 HOTAIR PRC2 RNA-DNA regulation binding surface assemble select histone modification enzymes thereby specifying the pattern of histone modifications on target genes 20616235
EL0578 HOTAIR HOXD RNA-Protein regulation The lncRNA HOTAIR is a putative direct positive regulator of the Polycomb repressor complex, and is consequently an indirect negative regulator of homeobox-D transcription factors. 20951849 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein regulation The lncRNA HOTAIR is a putative direct positive regulator of the Polycomb repressor complex. 20951849 LncRNADisease
EL0578 HOTAIR Ezh2 RNA-Protein binding Ezh2 interacts with HOTAIR and Xist. 21123648 LncRNADisease
EL0578 HOTAIR CoREST RNA-Protein binding Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. 21256239 LncRNADisease
EL0578 HOTAIR LSD1 RNA-Protein binding Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. 21256239 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. 21256239 LncRNADisease
EL0578 HOTAIR REST RNA-Protein binding Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. 21256239 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST. 21278485 LncRNADisease
EL0578 HOTAIR LSD1 RNA-Protein binding Analysis of HOTAIR revealed that a 5' end domain binds PRC2 and a 3' end domain binds an LSD1 (H3K4me2 demethylase) containing complex. 21496640 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding Analysis of HOTAIR revealed that a 5' end domain binds PRC2 and a 3' end domain binds an LSD1 (H3K4me2 demethylase) containing complex. 21496640 LncRNADisease
EL0578 HOTAIR HOXD RNA-DNA regulation HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793 LncRNADisease
EL0578 HOTAIR PRC2 RNA-Protein binding HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793 LncRNADisease
EL0578 HOTAIR H3 RNA-Protein regulation HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793 LncRNADisease
EL0578 HOTAIR Hox RNA-DNA regulation HOTAIR is transcribed from within specific Hox gene clusters but regulates the expression of Hox genes located on different chromosomes. 21936910 LncRNADisease
EL0578 HOTAIR EZH2 RNA-Protein binding HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation. 21936910 LncRNADisease
EL0578 HOTAIR β-catenin RNA-Protein regulation β-catenin is a stretch responsive signaling pathway that represses HOTAIR 24788418
EL0578 HOTAIR PPARγ and LPL RNA-DNA regulation Ectopic expression of HOTAIR in abdominal preadipocytes produced an increase in differentiation as reflected by a higher percentage of differentiated cells, and increased expression of key adipogenic genes including PPARγ and LPL 24862299
EL0578 HOTAIR Wnt inhibitory factor 1 RNA-Protein regulation A significant inverse correlation between HOTAIR and WIF-1 expression was demonstrated in Ta/T1 BC tissues. 25030736
EL0578 HOTAIR Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
EL0578 HOTAIR SiRNA RNA-RNA regulation SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation 25280565
EL0578 HOTAIR histone H3 lysine27 RNA-Protein binding MCF-7-TNR cells exhibited reduced suppressive histone H3 lysine27 trimethylation on the HOTAIR promoter. 25328122
EL0578 HOTAIR endothelial growth factor, matrix metalloproteinase-9 and epithelial-to-mesenchymal transition (EMT)-related genes RNA-DNA regulation HOTAIR regulated the expression of vascular endothelial growth factor, matrix metalloproteinase-9 and epithelial-to-mesenchymal transition (EMT)-related genes 25405331
EL0578 HOTAIR protein coding gene RNA-DNA regulation GO analyses of most significantly correlated coding genes of HOTAIR and lncRNA-422 showed that these two lncRNAs may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer. 25456707
EL0578 HOTAIR p21 RNA-DNA regulation Knockdown of HOTAIR upregulated p21. 25547435
EL0578 HOTAIR shHOTAIR RNA-RNA regulation Our findings demonstrated the shHOTAIR-mediated down-regulation of the HOTAIR expression in CD117(+)CD44(+) CSCs can be a promising new opportunity for future clinical trials. 25792974
EL0578 HOTAIR β-catenin DNA-Protein regulation We show that expression of HOTAIR is regulated by β-catenin through a LEF1/TCF4-binding site. The dual treatment blocks nuclear expression of β-catenin and prevents its recruitment to the HOTAIR promoter. 25883211
EL0578 HOTAIR c-KIT,miR-193a RNA-DNA binding HOTAIR modulated c-KIT expression by competitively binding miR-193a. 25979172
EL0578 HOTAIR miR-218 RNA-RNA regulation Hotair negatively regulated miR-218 expression in HCC, which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis. 26024833
EL0578 HOTAIR HIF-1α DNA-Protein binding The function of the hypoxia-inducible factor-1α (HIF-1α) binding site to hypoxia-responsive elements (HREs) in the HOTAIR promoter region. HOTAIR is a direct target of HIF-1α through interaction with putative HREs in the upstream region of HOTAIR in NSCLC cells. 26088446
EL0578 HOTAIR E7 RNA-Protein co-expression Expression of HOTAIR and PRC2-complex members (EZH2 and SUZ12), showed significant positive correlation with E7 expression in CaCx cases and E7 transfected C33A cell line, suggestive of interplay between E7 and HOTAIR. 26152361
EL0578 HOTAIR SETD2 RNA-DNA regulation HOTAIR promotes tumorigenesis via downregulating SETD2 in liver cancer stem cells. 26172293
EL0578 HOTAIR miR-326 RNA-RNA regulation HOTAIR was confirmed to be the target of miR-326 . knock-down of HOTAIR up-regulated miR-326 expression. 26183397
EL0578 HOTAIR miR-152 RNA-RNA regulation Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells. 26187665
EL0578 HOTAIR CaV1.2 RNA-Protein regulation In the present study, we demonstrated that up-regulation of HOTAIR could suppress the expression of CaV1.2 in human cardiomyocytes. 26255135
EL0578 HOTAIR Wnt/β-catenin pathway N/A regulation HOTAIR promotes the initiation and chemoresistance of ovarian cancer by activating wnt/β-catenin signaling. 26341496
EL0578 HOTAIR ER RNA-Protein regulation The long non-coding RNA HOTAIR is directly repressed by ER and its upregulation promotes ligand-independent ER activities and contributes to tamoxifen resistance. 26364613
EL0578 HOTAIR AR RNA-Protein binding HOTAIR binds to the AR protein to block its interaction with the E3 ubiquitin ligase MDM2, thereby preventing AR ubiquitination and protein degradation. 26411689
EL0578 HOTAIR EZH2 RNA-Protein regulation A significant correlation between EZH2 and HOTAIR expression levels. EZH2 regulates HOTAIR expression. 26457124
EL0578 HOTAIR microRNA-205 RNA-RNA regulation A long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter. 26469956
EL0578 HOTAIR cell death pathway N/A regulation Protein expression analysis indicated that mitochondrial related cell death pathway (Bcl-2, BAX, Caspase-3, Cleaved Caspase-3, Cytochrome c) involved in HOTAIR dependent apoptosis process. 26592246
EL0578 HOTAIR LSH RNA-Protein regulation HOTAIR is associated with LSH, and this association linked with the binding of LSH in the promoter of FOXA1, not FOXA2. 26658322
EL0578 HOTAIR FOXA1, FOXA2 RNA-Protein regulation HOTAIR regulates the ratio of FOXA1 to FOXA2 and migration and invasion. 26658322
EL0578 HOTAIR VEGFA and Ang2 RNA-Protein regulation Hotair promoted angiogenesis through directly activating the transcription of angiogenic factor VEGFA as well as through GRP78-mediated upregulation of VEGFA and Ang2 expression. 26717040
EL0578 HOTAIR c-Myc RNA-DNA binding HBXIP interacted directly with c-Myc through the leucine zippers and recruited the lncRNA Hotair along with the histone demethylase LSD1, for which Hotair serves as a scaffold. 26719542
EL0578 HOTAIR epithelial-to-mesenchyme transition (EMT) genes RNA-DNA regulation Loss of HOTAIR expression in UBC cell lines alters expression of epithelial-to-mesenchyme transition (EMT) genes including SNAI1, TWIST1, ZEB1, ZO1, MMP1 LAMB3, and LAMC2. 26800519
EL0578 HOTAIR TNF-α, NF-κB RNA-Protein regulation HOTAIR upregulation in cardiomyocytes of LPS-induced sepsis mice promoted TNF-α production in the circulation by activating NF-κB, involving the phosphorylation of NF-κB p65 subunit. 26806307
EL0578 HOTAIR miR-125a-5p RNA-RNA regulation microRNA miR-125a-5p decreases and releases caspase 2 to promote cancer cell apoptosis after HOTAIR knockdown. 26962687
EL0579 Hotair HOXD genes RNA-DNA regulation We show that the cognate mouse Hotair is poorly conserved in sequence; and its absence, along with the deletion of the HoxC cluster, has surprisingly little effect in vivo, neither on the expression pattern or transcription efficiency, nor on the amount of K27me3 coverage of different Hoxd target genes. 21637793
EL0579 Hotair Polycomb repressive complex 2 and Lsd1 complex RNA-Protein binding Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo. Hotair inactivation causes H3K4me3 gain and, to a lesser extent, H3K27me3 loss at target genes. 24075995
EL0579 Hotair HoxD RNA-DNA regulation RNA sequencing and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and several imprinted loci such as Dlk1-Meg3 and Igf2-H19 without affecting imprinting choice. 24075995
EL0580 HOTAIRM1 HOXA1 and HOXA4 RNA-DNA regulation Knockdown of HOTAIRM1 quantitatively blunted RA-induced expression of HOXA1 and HOXA4 during the myeloid differentiation of NB4 cells, and selectively attenuated induction of transcripts for the myeloid differentiation genes CD11b and CD18, but did not noticeably impact the more distal HOXA genes. 19144990
EL0580 HOTAIRM1 HOXA1 RNA-RNA co-expression HOTAIRM1 knockdown in NB4 cells prevented RA induction of HOXA1 and A4. 21874119 LncRNADisease
EL0580 HOTAIRM1 HOXA4 RNA-RNA co-expression HOTAIRM1 knockdown in NB4 cells prevented RA induction of HOXA1 and A4. 21874119 LncRNADisease
EL0580 HOTAIRM1 miR-196b DNA-RNA co-expression HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). 26433964
EL0582 HOTTIP HOXA RNA-Protein binding HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription. 21423168 LncRNADisease
EL0582 HOTTIP HOXA RNA-Protein binding HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription. 21423168 LncRNADisease
EL0582 HOTTIP WDR5 RNA-Protein binding HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription. 21423168 LncRNADisease
EL0582 HOTTIP WDR5 RNA-Protein binding HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription. 21423168 LncRNADisease
EL0582 HOTTIP HOXA RNA-DNA regulation Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP HOXA RNA-DNA regulation Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP Mll1 RNA-Protein binding Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP Mll1 RNA-Protein binding Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP Wdr5 RNA-Protein binding Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP Wdr5 RNA-Protein binding Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes. 21423168 LncRNADisease
EL0582 HOTTIP WDR5 RNA-Protein binding HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription. 21423168
EL0582 HOTTIP WDR5 RNA-Protein binding HOTTIP was shown to mediate enhancerlike effects on the adjacent genes through a mechanism involving direct interaction with the adaptor protein WDR5. 21831473 LncRNADisease
EL0582 HOTTIP HOXA DNA-DNA regulation This study identified HOTTIP in association with the promoter regions of downstream 5'HOXA genes. 21831473 LncRNADisease
EL0582 HOTTIP HOXA RNA-RNA co-expression Knockdown of HOTTIP in foreskin fibroblasts resulted in lower 5’HOXA gene expression. 21874119 LncRNADisease
EL0582 HOTTIP WDR5 RNA-Protein binding HOTTIP and Mistral recruit chromatin-activating complexes (WDR5/MLL1) in cis to neighboring genes. 22190456 LncRNADisease
EL0582 HOTTIP FLJ21870 RNA-RNA co-expression Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal. 23728290
EL0582 HOTTIP HOXA gene cluster,miR-125b RNA-DNA, RNA-RNA regulation Knock-down of HOTTIP significantly suppressed the expression of a number of HOXA genes. Furthermore, we identified miR-125b as a post-transcriptional regulator of HOTTIP. 25424744
EL0582 HOTTIP HOXA13 RNA-Protein regulation Knockdown of HOXA13 by RNA interference (siHOXA13) revealed that HOTTIP promoted PDAC cell proliferation, invasion, and chemoresistance, at least partly through regulating HOXA13. 25889214
EL0582 HOTTIP HOX gene RNA-DNA regulation HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes includingHOXA10, HOXB2, HOXA11, HOXA9 and HOXA1. 25912306
EL0582 HOTTIP HOXA13 RNA-Protein co-expression LncRNA HOTTIP and HOXA13 were significantly down-regulated in HSCR compared to the controls. SiRNA-mediated knock-down of HOTTIP or HOXA13 correlated with decreased levels of each other and both reduced the cell migration and proliferation without affecting cell apoptosis or cell cycle. 26043692
EL0582 HOTTIP p21 RNA-Protein regulation HOTTIP potentially contributed to CRC cell growth partially through the silencing of p21 expression. 26678886
EL0582 HOTTIP miR-192 and miR-204 DNA-RNA regulation miR-192 and miR-204 as two microRNAs (miRNAs) suppressing HOTTIP expression via the Argonaute 2 (AGO2)-mediated RNA interference (RNAi) pathway in HCC. The posttranscriptional silencing of HOTTIP by miR-192, miR-204 or HOTTIP siRNAs could significantly suppress viability of HCC cells. The miR-192/-204-HOTTIP axis may interrupt HCC glutaminolysis through GLS1 inhibition. Besides the known targets (multiple 5' end HOX A genes, i.e. HOXA13), glutaminase (GLS1) was identified as a potential downstream target of the miR-192/-204-HOTTIP axis in HCC. 26710269
EL0584 HOXA11-AS HOXA11 RNA-DNA regulation Hoxa11 antisense functions by transcriptional interference, repressing hoxa11 expression by competing for transcription of the common gene, rather than by sense/antisense interaction. 12050232
EL0584 HOXA11-AS Hoxa 11 RNA-RNA co-expression In the developing limbs, the sense and antisense transcripts showed complementary expression patterns 7789268
EL0585 Hoxa11os Hoxa11 RNA-DNA regulation attempts to block hoxa11 function by transfection of the murine uterus with hoxa11 antisense oligonucleotides failed to interrupt normal uterine function, suggesting that hoxa11 antisense does not regulate hoxa11 mrna by formulation of sense/antisense duplexes. 12050232
EL0587 HOXA-AS HOXA gene RNA-DNA regulation We have investigated the intergenic, noncoding transcriptomes of mammalian HOX clusters. We show that "opposite strand transcription" from the intergenic spacer regions in the human HOXA cluster correlates with the activity state of adjacent HOXA genes. This noncoding transcription is regulated by the retinoic acid morphogen and follows the colinear activation pattern of the cluster. Opening of the cluster at sites of activation of intergenic transcripts is accompanied by changes in histone modifications and a loss of interaction with Polycomb group (PcG) repressive complexes. 17185360
EL0588 HOXA-AS2 EZH2 (enhaner of zeste homolog 2) RNA-Protein binding HOXA-AS2 could epigenetically repress the expression of P21, PLK3, and DDIT3 via binding with EZH2 (enhaner of zeste homolog 2), a key component of PRC2 26384350
EL0588 HOXA-AS2 P21/PLK3/DDIT3 RNA-Protein regulation HOXA-AS2 could epigenetically repress the expression of P21, PLK3, and DDIT3 via binding with EZH2 (enhaner of zeste homolog 2), a key component of PRC2 26384350
EL0589 Hoxaas3 Hoxa3 RNA-DNA regulation 05Rik overexpression suppressed Hoxa3 transcription 26824344
EL0592 HSR1 HSF-1 RNA-Protein regulation The ncRNAs NRSE and HSR have been shown to regulate the activity of REST and HSF-1, respectively. 19191220 LncRNADisease
EL0592 HSR1 HSF1 RNA-Protein binding Heat-shock factor 1 (HSF1) A third protein-binding lncRNA is HSR1 (heat shock RNA-1), a 604 nucleotide RNA that, together with eukaryotic translationelongation factor 1A, stimulates trimerization of heat-shock factor 1 (HSF1). 19239885 LncRNADisease
EL0592 HSR1 HSF1 RNA-Protein binding Heat-shock RNA 1 (HSR1) binds heat-shock transcription factor 1 (HSF1), facilitating its ability to activate genes encoding heat-shock proteins. 22190456 LncRNADisease
EL0593 Hsromega hnRNPs RNA-Protein binding Immunoprecipitation studies using the hnrnp antibodies further demonstrated a physical association of hnrnps and hsromega transcripts. 10984439
EL0593 Hsromega hnRNPs RNA-Protein regulation It appears that the p transposon insertion in the promoter region causes a misregulated overexpression of hsromega in cyst cells, which in turn results in excessive sequestration of hnrnps and formation of large clusters of omega speckles in these cell nuclei. 11910129
EL0593 Hsromega 127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene RNA-Protein regulation Loss of hsromega-n RNA not only suppresses the eye-specific degeneration mediated by GMR-GAL4 driven expression of the 127Q or MJDtr-Q78 or ataxin1 82Q or httex1p Q93 transgene, but also rescues premature death of flies expressing the expanded polyQ proteins pan-neuronally using the elav-GAL4 driver. 19667761
EL0594 HSUR1 host mRNAs RNA-RNA regulation Hsur 1 and 2 expression correlates with significant increases in a small number of host mrnas, including the t cell-receptor beta and gamma chains, the t cell and natural killer (nk) cell-surface receptors cd52 and dap10, and intracellular proteins--skap55, granulysin, and nkg7--linked to t cell and nk cell activation. 15916956
EL0594 HSUR1 miR-27 RNA-RNA binding Transient knockdown and ectopic expression of HSUR 1 demonstrate that it directs degradation of mature miR-27 in a sequence-specific and binding-dependent manner. 20558719
EL0595 HSUR2 host mRNAs RNA-RNA regulation Hsur 1 and 2 expression correlates with significant increases in a small number of host mrnas, including the t cell-receptor beta and gamma chains, the t cell and natural killer (nk) cell-surface receptors cd52 and dap10, and intracellular proteins--skap55, granulysin, and nkg7--linked to t cell and nk cell activation. 15916956
EL0600 HULC miR-372 RNA-RNA binding Acts as a sponge/target mimic for miR-372 reducing its expression and activity. 21256239 LncRNADisease
EL0600 HULC miR-372 RNA-DNA regulation highly upregulated in liver cancer (HULC) lncRNA sequesters endogenous miR-372 to modulate its own transcriptional upregulation in HCC. 21802130 LncRNADisease
EL0600 HULC CLOCK RNA-Protein regulation Our observations showed that HULC was able to heighten the expression levels of CLOCK and its downstream circadian oscillators 25622901
EL0600 HULC p18 RNA-Protein regulation RIP assay showed that HULC down-regulated the level of p18 directly. 25952928
EL0600 HULC E2F1 RNA-TF regulation HULC activated the promoter of SPHK1 in hepatoma cells through the transcription factor E2F1. E2F1 was capable of binding to the E2F1 element in the SPHK1 promoter. HULC increased the expression of E2F1 in hepatoma cells and levels of HULC were positively correlated with those of E2F1 in HCC tissues. 26540633
EL0600 HULC SPHK1 RNA-Protein regulation HULC increased SPHK1 in hepatoma cells. 26540633
EL0600 HULC miR-107 RNA-RNA regulation HULC sequestered miR-107, which targeted E2F1 mRNA 3'UTR, by complementary base pairing. 26540633
EL0600 HULC TNF-α RNA-Protein regulation HULC expression was decreased with TNF-α treatment. Restoring HULC expression rescued the apoptosis induced by TNF-α. 26981838
EL0600 HULC miR-9 RNA-RNA regulation HULC modulated miR-9 expression through association with DNA methyltransferases and suppression of miR-9 expression. 26981838
EL0602 HvCesA6 Csl genes, and GT8 glycosyl transferase genes RNA-DNA regulation Virus induced gene silencing using unique target sequences derived from HvCesA genes attenuated expression not only of the HvCesA6 gene, but also of numerous nontarget Csls and the distantly related GT8 genes and reduced the incorporation of D-(14)C-Glc into cellulose and into mixed-linkage (1 --> 3),(1 --> 4)-beta-D-glucans of the developing leaves. 19075248 PLNlncRbase
EL0603 HvISP1 HvPHT1;3, HvPHT1;6 DNA-DNA co-expression Interestingly, the expression of HvPHT1;6 and HvPHT1;3 was correlated with the expression of HvIPS1 (for P starvation inducible; noncoding RNA) 21606317 PLNlncRbase
EL0605 ICR ICAM-1 RNA-RNA regulation ICR regulated ICAM-1 expression by increasing the stability of its mRNA through RNA duplex formation. 26667486
EL0606 ICR1 FLO11 RNA-DNA regulation ICR1 could repress FLO11 transcription by occluding its promoter. 19805129 LncRNADisease
EL0606 ICR1 Sfl1 DNA-TF regulation ICR1 is barely detectable in sfl1 mutants in which Rpd3L function is still intact, indicating that Sfl1 function normally promotes ICR1 transcription. 19805129 LncRNADisease
EL0606 ICR1 Flo8 RNA-Protein regulation These data implicate Flo8 and Rpd3L as repressors of ICR1. 19805129 LncRNADisease
EL0606 ICR1 Rpd3L RNA-Protein regulation These data implicate Flo8 and Rpd3L as repressors of ICR1. 19805129 LncRNADisease
EL0607 IFNG-AS1 IgG RNA-Protein regulation The level of expression of TMEVPG1 was correlated with the level of SSA, ESR and IgG. 26440590
EL0607 IFNG-AS1 IFNG RNA-Protein regulation IFNG-AS1 regulated the expression of IFNG at both transcriptional and translational level in human CD4(+) T cells. Strong positive correlations between the increased transcript level of IFNG-AS1 and the increased transcript level of T-bet or IFNG were revealed in thyroid tissues from HT patients. 26634912
EL0609 IL7R H3K27me3 RNA-Protein regulation lnc-IL7R knockdown diminished trimethylation of histone H3 at lysine 27 (H3K27me3), a hallmark of silent transcription, at the proximal promoters of the inflammatory mediators. 24723426
EL0610 ILF3 NF90 (nuclear factor of activated T-cells, 90 kDa) RNA-Protein regulation SALNR interacts with NF90 (nuclear factor of activated T-cells, 90 kDa), an RNA-binding protein suppressing miRNA biogenesis. NF90 is a SALNR downstream target, whose inhibition led to premature senescence and enhanced expressions of senescence-associated miRNAs. 26487301
EL0613 IPS1 miR-399 RNA-RNA regulation The IPS1 ncRNA is poorly evolutionarily conserved except for a short motif that is highly complementary to miR-399, a miRNA that is induced in response to phosphate starvation, although the basepairing is interrupted by a mismatched loop at the expected miRNA cleavage site. This interruption in basepairing causes the IPS1 ncRNA to be noncleavable and instead allows IPS1 to sequester miR-399, resulting in increased expression of miR-399 target genes. 19571179 LncRNADisease
EL0613 IPS1 PHO2 RNA-RNA regulation N/A 22104407, 17643101, 23429259, 19447594, 24523727 PLNlncRbase
EL0614 IPS1 PHO2 RNA-RNA regulation IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. 17643101 PLNlncRbase
EL0615 IPS1 PHO2 RNA-RNA regulation IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. 17643101 PLNlncRbase
EL0616 IPS1 PHO2 RNA-RNA regulation IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. 17643101 PLNlncRbase
EL0617 IPS1 PHO2 RNA-RNA regulation IPS1 overexpression results in increased accumulation of the miR-399 target PHO2 mRNA and, concomitantly, in reduced shoot Pi content. 17643101 PLNlncRbase
EL0619 IRAIN chromatin DNA RNA-DNA regulation this lncRNA interacts with chromatin DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop. 25092925
EL0622 Jpx XIST RNA-RNA regulation For the inactive X, here, Xic-encoded Jpx is an Xist activator. Jpx is trans-acting and functions as ncRNA. 21029862 LncRNADisease
EL0622 Jpx XIST RNA-RNA regulation Xist is controlled by two parallel RNA switches – Tsix for Xa and Jpx for Xi. Jpx activates Xist on Xi. 21029862 LncRNADisease
EL0622 Jpx XIST RNA-RNA regulation Regulates X chromosome inactivation in mammals via activation of the Xist lncRNA. 21256239 LncRNADisease
EL0622 Jpx XIST RNA-DNA regulation Jpx lncRNA acts as a positive regulator of Xist. 21329697 LncRNADisease
EL0622 Jpx XIST RNA-DNA regulation Xist expression and X inactivation could be rescued by a Jpx transgene located on another chromosome, indicating that Jpx can exert its effects in trans. 21496640 LncRNADisease
EL0628 KCNQ1OT1 chromatin RNA-DNA binding The bidirectional silencing property of Kcnq1ot1 maps to a highly conserved repeat motif within the silencing domain, which directs transcriptional silencing by interaction with chromatin, resulting in histone H3 lysine 9 trimethylation 18299392
EL0628 KCNQ1OT1 H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex RNA-Protein binding Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner. This interaction correlates with the presence of extended regions of chromatin enriched with H3K9me3 and H3K27me3 in the Kcnq1 domain in placenta, whereas fetal liver lacks both chromatin interactions and heterochromatin structures 18951091
EL0628 KCNQ1OT1 KvDMR1 and the Kcnq1 RNA-DNA binding The 5' region of Kcnq1ot1 RNA orchestrates a long-range intrachromosomal loop between KvDMR1 and the Kcnq1 promoter that is required for maintenance of imprinting.PRC2 (polycomb repressive complex 2), which participates in the allelic repression of Kcnq1, is also recruited by Kcnq1ot1 RNA via EZH2. 24395636
EL0628 KCNQ1OT1 SLC22A18, PHLDA2 RNA-DNA regulation Knockdown of β-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. 26868975
EL0628 KCNQ1OT1 β-catenin DNA-Protein binding β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. 26868975
EL0629 Kcnq1ot1 G9a RNA-Protein binding Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner. 18951091 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner. 18951091 LncRNADisease
EL0629 Kcnq1ot1 H3K9me2 and H3K27me3 RNA-Protein regulation Gene silencing by the Kcnq1ot1 RNA involves repressive histone modifications, including H3K9me2 and H3K27me3, which are partly brought about by the G9a and Ezh2 histone methyltransferases. 19144718
EL0629 Kcnq1ot1 G9a RNA-Protein binding The Kcnq1ot1 RNA also binds to the histone methyltransferase G9a. 19239885 LncRNADisease
EL0629 Kcnq1ot1 G9a RNA-Protein binding The Kcnq1ot1 transcript that binds both G9a and PRC2. 19571010 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding The Kcnq1ot1 transcript that binds both G9a and PRC2. 19571010 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding PRC2 recruitment to the domain requires expression of the long ncRNA Kcnq1ot1. 19760321 LncRNADisease
EL0629 Kcnq1ot1 Dnmt1 RNA-Protein binding Kcnq1ot1 mediates transcriptional gene silencing by interacting with Dnmt1. Kcnq1ot1 recruits Dnmt1 to somatic DMRs by interacting with Dnmt1. 20573698 LncRNADisease
EL0629 Kcnq1ot1 Dnmt1 RNA-DNA binding Kcnq1ot1 recruits Dnmt1 to somatic DMRs by interacting with Dnmt1 20573698
EL0629 Kcnq1ot1 Kcnq1 RNA-DNA regulation Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 Kcnq1 RNA-DNA regulation Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 Dnmt1 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 Dnmt1 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 G9a RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 G9a RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 PRC1 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 PRC1 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1. 21256239 LncRNADisease
EL0629 Kcnq1ot1 G9a RNA-Protein binding Kcnq1ot1 interacts with the histone methyltransferases G9a and PRC2, effectively forming a repression domain in cis to its transcription site through recruitment of polycomb complexes. 21925379 LncRNADisease
EL0629 Kcnq1ot1 PRC2 RNA-Protein binding Kcnq1ot1 interacts with the histone methyltransferases G9a and PRC2, effectively forming a repression domain in cis to its transcription site through recruitment of polycomb complexes. 21925379 LncRNADisease
EL0629 Kcnq1ot1 EZH2 RNA-Protein binding HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation. 21936910 LncRNADisease
EL0629 Kcnq1ot1 Kcnq DNA-DNA regulation Kcnq1ot is important for silencing of the Kcnq locus resulting from parental imprinting. 21936910 LncRNADisease
EL0630 Khps1 SPHK1 RNA-DNA binding Mechanistically, this is achieved by direct association of Khps1 with a homopurine stretch upstream of the transcription start site of SPHK1, which forms a DNA-RNA triplex that anchors the lncRNA and associated effector proteins to the gene promoter. 26590717
EL0631 Khps1a Sphk1 RNA-DNA regulation Regulates DNA methylation in the tissue-dependent differentially methylated region of Sphk1. 21256239 LncRNADisease
EL0632 KIR antisense lncRNA MZF-1 RNA-TF binding The antisense promoter contains myeloid zinc finger 1 (MZF-1)-binding sites, a transcription factor found in hematopoietic progenitors and myeloid precursors. 23863987
EL0647 LINC00160 ERα DNA-Protein regulation LINC01016 and LINC00160 are direct transcriptional targets of ERα, correlate with Erα expression in clinical samples, and show prognostic significance in relation to breast cancer survival. 26423156
EL0651 LINC00261 FOXA2 RNA-DNA regulation Mechanistically, DEANR1 facilitates FOXA2 activation by facilitating SMAD2/3 recruitment to the FOXA2 promoter. 25843708
EL0654 LINC00312 ERA RNA-DNA regulation ERR-10 (LINC00312): a new repressor in transcriptional signaling activation of estrogen receptor-alpha. 15474036 LncRNADisease
EL0661 LINC00570 ROCK2 RNA-RNA co-expression depletion of ncRNA-a5 resulted in a specific reduction in ROCK2 expression levels in HeLa cells, which is located upstream of ncRNA-a5. 20887892 LncRNADisease
EL0661 LINC00570 CMPK1 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. 21502407 LncRNADisease
EL0663 LINC00635-001 Akt RNA-Protein regulation Silencing of LINC00635-001 alone did not remarkably impact HCC827-8-1 cells, but its combination with gefitinib treatment inhibited Akt activation and sensitized HCC827-8-1 cells to gefitinib-induced cytotoxicity. 26792719
EL0666 LINC00668 E2F1 RNA-TF regulation LINC00668 was a direct transcriptional target of E2F transcription factor 1 (E2F1). 27036039
EL0666 LINC00668 PRC2 RNA-Protein regulation LINC00668 was associated with PRC2 and that this association was required for epigenetic repression of cyclin-dependent protein kinase inhibitors (CKIs), including p15, p16, p21, p27 and p57, thus contributing to the regulation of the gastric cancer cell cycle. 27036039
EL0669 LINC00853 CMPK1 RNA-RNA co-expression reduced levels of ncRNA-a4 resulted in a consistent and significant decrease in the level of the gene CMPK1 which is over 150 kb downstream of ncRNA-a4. 20887892 LncRNADisease
EL0672 LINC00951 rs11752942G allele DNA-RNA regulation rs11752942G allele could markedly attenuate the level of lincRNA-uc003opf.1 both in vivo and in vitro by binding micro-RNA-149*, thereby affecting cell proliferation and tumor growth 23872665
EL0674 LINC00964 piR-015551 RNA-DNA regulation Furthermore, the authors observed that mRNA expression levels of LNC00964-3 (an lncRNA that included the piR-015551 sequence but not piR-015551) were significantly lower in CRC tissues than in corresponding normal tissues 25740697
EL0676 LINC00974 KRT19 RNA-RNA co-expression Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-β pathways as detected by cDNA microarray. 25476897
EL0677 LINC00982 P15 and P16 protein RNA-Protein regulation Ectopic expression of LINC00982 inhibited cell proliferation and rendered cell cycle arrest in GC cells partly via regulating P15 and P16 protein expressions. 26334618
EL0679 LINC01016 ERα DNA-Protein regulation LINC01016 and LINC00160 are direct transcriptional targets of ERα, correlate with Erα expression in clinical samples, and show prognostic significance in relation to breast cancer survival. 26423156
EL0681 LINC01021 p53 DNA-DNA regulation Up-regulation of the novel direct p53 target genes LINC01021, MDFI, ST14 and miR-486 and showed that ectopic LINC01021 expression inhibits proliferation in SW480 cells. 26183718
EL0682 LINC01024 Purα RNA-DNA regulation MA-linc1 predominantly functions in cis to repress expression of its neighboring gene, Purα, which is often deleted in human cancers and whose ectopic expression inhibits cell cycle progression. 26337085
EL0687 LINC01158 TGF-beta RNA-Protein regulation linc-POU3F3 could promote the distribution of Tregs in peripheral blood T cell which caused an enhanced cell proliferation of gastric cancer cells by recruiting TGF-beta as well as activating TGF-beta signal pathway. 26807174
EL0688 LINC01207 Bad RNA-DNA regulation LINC01207 could bind with EZH2 and mediated trimethylation of histone 3 lysine 27 at the promoter region of Bad, an important pro-apoptotic gene. 26693067
EL0688 LINC01207 EZH2 RNA-Protein binding LINC01207 could bind with EZH2 and mediated trimethylation of histone 3 lysine 27 at the promoter region of Bad, an important pro-apoptotic gene. 26693067
EL0695 LINC01426 RUNX1 and alternative splicing (AS) factors RNA-Protein regulation lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPα (CCAAT/enhancer-binding protein-α) gene expression 25486427
EL0705 LINC01613 miR-21, miR-31, miR-101, miR-29, miR-199, and let-7d RNA-RNA binding The sequences of the dysregulated microRNAs in IPF including miR-21, miR-31, miR-101, miR-29, miR-199, and let-7d were used to search NONCODE database containing 33,829 human lncRNAs. A total of 34 lncRNAs with potential binding sites to these microRNAs were identified. Four of them were inversely correlated to the microRNA expression in IPF. 26269497
EL0716 lincDR1 IgG RNA-Protein binding binding with IgG shown by RIP-Chip data. 19571010 LncRNADisease
EL0716 lincDR1 PRC2 RNA-Protein binding binding with PRC2 shown by RIP-Chip data. 19571010 LncRNADisease
EL0717 lincGARS IgG RNA-Protein binding binding with IgG shown by RIP-Chip data. 19571010 LncRNADisease
EL0717 lincGARS PRC2 RNA-Protein binding binding with PRC2 shown by RIP-Chip data. 19571010 LncRNADisease
EL0718 linc-ITGB1 N-cadherin, vimentin, E-cadherin, Cdc25C, Cyclin B1 RNA-Protein regulation The linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. 26601916
EL0720 lincMLKN1 IgG RNA-Protein binding binding with IgG shown by RIP-Chip data. 19571010 LncRNADisease
EL0720 lincMLKN1 PRC2 RNA-Protein binding binding with PRC2 shown by RIP-Chip data. 19571010 LncRNADisease
EL0723 LincR-Ccr2-5'AS GATA-3 DNA-Protein regulation Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. 24056746
EL0747 LINC-ROR Nanog DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
EL0747 LINC-ROR 41186 DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
EL0747 LINC-ROR Sox2 DNA-TF regulation lincRNA-RoR, was shown to be directly targeted by the key pluripotency factors Oct4, Sox2, and Nanog through colocalization of the three factors close its promoter region. 21925379 LncRNADisease
EL0747 LINC-ROR p70S6K1 (RPS6KB1), PDK1 and HIF-1α RNA-Protein regulation siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). 24463816
EL0747 LINC-ROR miR-145 RNA-RNA regulation siRNA to linc-RoR decreased phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and increased expression of the linc-RoR target microRNA-145 (miR-145). 24463816
EL0747 LINC-ROR NRF2 RNA-TF binding NRF2 binds to two specific NRF2 response elements flanking the ROR promoter and that these two NRF2 response elements are equally important to suppress ROR transcription. In addition, we identified associated H3K27me3 chromatin modification and EZH2 binding at the ROR promoter that was dependent on NRF2 binding. 25231996
EL0747 LINC-ROR TESC RNA-DNA regulation lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation. 26169368
EL0747 LINC-ROR miR-145 RNA-RNA regulation ROR may act as a ceRNA, effectively becoming a sink for miR-145, thereby activating the derepression of core transcription factors Nanog. 26636540
EL0749 lincSFPQ IgG RNA-Protein binding binding with IgG shown by RIP-Chip data. 19571010 LncRNADisease
EL0749 lincSFPQ PRC2 RNA-Protein binding binding with PRC2 shown by RIP-Chip data. 19571010 LncRNADisease
EL0749 lincSFPQ PRC2 RNA-Protein binding Numerous lincRNAs are physically associated with PRC2. 19571010 LncRNADisease
EL0750 LINK-A BRK RNA-Protein regulation LINK-A facilitates the recruitment of BRK to the EGFR:GPNMB complex and BRK kinase activation. 26751287
EL0753 lnc13 hnRNPD RNA-Protein binding Lnc13 regulates gene expression by binding to hnRNPD, a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). 27034373
EL0758 Lnc34a miR-34a RNA-DNA regulation Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53. 27077950
EL0763 lncARSR AXL and c-MET RNA-DNA regulation lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. 27117758
EL0763 lncARSR miR-34/miR-449 RNA-RNA binding lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. 27117758
EL0764 lnc-bc060912 p53,PARP1 and NPM1 RNA-Protein regulation we found that Lnc_bc060912 interacted with the two DNA damage repair proteins PARP1 and NPM1 25848691
EL0768 lnc-DILC interleukin-6 (IL-6) promoter RNA-Protein regulation lnc-DILC mediates the crosstalk between TNF-α/NF-κB signaling and autocrine IL-6/STAT3 cascade and connects hepatic inflammation with LCSC expansion 26812074
EL0768 lnc-DILC TNF-α/NF-κB RNA-Protein regulation lnc-DILC mediates the crosstalk between TNF-α/NF-κB signaling and autocrine IL-6/STAT3 cascade and connects hepatic inflammation with LCSC expansion 26812074
EL0768 lnc-DILC STAT3 RNA-Protein regulation STAT3 activation and LCSC expansion triggered by lnc-DILC depletion and lnc-DILC overexpression. 26812074
EL0775 lncLGR GCK RNA-DNA regulation lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription. 26904944
EL0775 lncLGR heterogenous nuclear ribonucleoprotein L (hnRNPL) RNA-DNA binding lncLGR specifically binds to heterogenous nuclear ribonucleoprotein L (hnRNPL), which is further confirmed to be a transcriptional repressor of GCK in vivo. 26904944
EL0791 lncRNA-422 protein coding gene RNA-DNA regulation GO analyses of most significantly correlated coding genes of HOTAIR and lncRNA-422 showed that these two lncRNAs may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer. 25456707
EL0797 lncRNA-AK058803 γ-synuclein gene (SNCG) RNA-DNA regulation Unregulated lncRNA-AK058003 in breast cancer cells promotes cancer cell proliferation, invasion and metastasis via the regulation of SNCG expression. 26136884
EL0799 lncRNA-ATB SB431542 RNA-RNA regulation Treatment with TGF-β in GC cell lines resulted in morphological EMT changes, upregulation of lncRNA-ATB and ZEB1, and downregulation of miR-200c and CDH1. SB431542 reduced lncRNA-ATB expression 25986864
EL0799 lncRNA-ATB E-cadherin RNA-DNA regulation Long non-coding RNA-activated by TGF-β may act on colon tumorigenesis by suppressing E-cad expression and promoting EMT process 26487301
EL0801 lncRNA-HSVIII Prss42/Tessp-2 RNA-DNA regulation The lncRNA-HSVIII locus specifically interacted with the Prss42/Tessp-2 promoter in primary and secondary spermatocytes. 27111572
EL0812 LOC100129973 miR-4707-5p and miR-4767 RNA-RNA binding Through sponging miR-4707-5p and miR-4767, lncRNA LOC100129973 upregulated the expression of two apoptosis repressors gene, Apoptosis Inhibitor 5 (API5) and BCL2 like 12 (BCL2L12). 26887505
EL0822 LOC105246506 Nanog DNA-TF regulation AK141205 is repressed by the transcription factor Nanog. 20026622 LncRNADisease
EL0822 LOC105246506 Oct4 and Nanog RNA-DNA binding AK028326 (Oct4-activated) and AK141205 (Nanog-repressed), are direct targets of Oct4 and Nanog. 20026622
EL0822 LOC105246506 CXCL13; Nanog RNA-Protein regulation Analysis of CXCL13 expression in SMCs(pcDNA-AK141205) revealed that AK141205 positively promoted CXCL13 expression via acetylation of H4 histone in the promoter region (co-expression); Nanog may directly repress transcription of lncRNA AK141205 (regulation). 26321662; 20026622
EL0829 LOC389641 E-cadherin RNA-Protein co-expression A significant negative correlation was observed between E-cadherin levels and LOC389641 levels in vivo. Knockdown of LOC389641 upregulated E-cadherin expression, but knockdown of E-cadherin had a limited influence on LOC389641. Importantly, after E-cadherin was inhibited, the enhancement of LOC389641 on cell invasion was hindered. 26708505
EL0829 LOC389641 TNFRSF10A DNA-DNA regulation The expression of LOC389641 was closely associated with its genomic neighboring gene TNFRSF10A. Lastly, knockdown experiments showed that TNFRSF10A might be a connection between LOC389641and E-cadherin. 26708505
EL0831 LOC401317 TP53 RNA-DNA regulation Further studies indicated that LOC401317 is directly regulated by p53 and that ectopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. 25422887
EL0843 LSINCT5 PSPC1 RNA-RNA co-expression Two genes that were significantly downregulated were the lncRNA NEAT-1 and a protein coding gene PSPC1. 21532345 LncRNADisease
EL0848 LUADT1 p27 RNA-DNA regulation LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. 26291312
EL0848 LUADT1 SUZ12 RNA-Protein binding LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. 26291312
EL0850 LUNAR1 IGF1R RNA-RNA regulation one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. 25083870
EL0850 LUNAR1 E2F1, cyclin D1 and p21 RNA-Protein regulation LUNAR1 knockdown significantly repressed cell proliferation of DLBCL by regulating E2F1, cyclin D1 and p21. 26796267
EL0853 MALAT1 CREB DNA-TF regulation We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line. 20149803 LncRNADisease
EL0853 MALAT1 SR RNA-Protein binding MALAT1 interacts with SR proteins and influences the distribution of these and other splicing factors in nuclear speckle domains. 20797886 LncRNADisease
EL0853 MALAT1 SR proteins RNA-Protein binding MALAT1 interacts with SR proteins and influences the distribution of these and other splicing factors in nuclear speckle domains. 20797886
EL0853 MALAT1 SR protein family RNA-Protein regulation MALAT1 regulates the expression level, localization, and activity SR proteins. 20864030 LncRNADisease
EL0853 MALAT1 SRSF1 RNA-Protein regulation Upon MALAT1 depletion, expression of SRSF1 protein is increased. 20864030 LncRNADisease
EL0853 MALAT1 p54nrb RNA-Protein binding In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. 21444682 LncRNADisease
EL0853 MALAT1 PSF RNA-Protein binding In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. 21444682 LncRNADisease
EL0853 MALAT1 Pc2 DNA-Protein regulation methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2. 22078878 LncRNADisease
EL0853 MALAT1 Pc2 DNA-Protein regulation Methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2. 22078878 LncRNADisease
EL0853 MALAT1 RNPS1 RNA-Protein regulation RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-1 to the nucleoplasm. 22355166 LncRNADisease
EL0853 MALAT1 SRm160 RNA-Protein regulation RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-2 to the nucleoplasm. 22355166 LncRNADisease
EL0853 MALAT1 IBP160 RNA-Protein regulation RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-3 to the nucleoplasm. 22355166 LncRNADisease
EL0853 MALAT1 pre-mRNA splicing factors RNA-Protein regulation MALAT1 interacts with pre-mRNA splicing factors and regulates cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation. 23698766
EL0853 MALAT1 Bcl-2 RNA-DNA regulation An interaction of Bcl-2 with MALAT-1 lncRNA expression was revealed. 25036876
EL0853 MALAT1 Sp1 and LTBP3 promoter RNA-DNA binding lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoterto increase expression of LTBP3 gene. 25187517
EL0853 MALAT1 Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
EL0853 MALAT1 SiRNA RNA-RNA regulation SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation 25280565
EL0853 MALAT1 PI3K/AKT signaling pathway RNA-Protein regulation MALAT1 might suppress the tumor growth and metastasis via I3K/AKT signaling pathway. 25431257
EL0853 MALAT1 miR-101 and miR-217 RNA-RNA regulation A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. 25538231
EL0853 MALAT1 CCL5 RNA-Protein regulation The stimulation of colon cancer progression by TADC-derived CCL5 was associated with the up-regulation of non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), which subsequently increased the expression of Snail. 25546229
EL0853 MALAT1 ATM-CHK2 pathway RNA-Protein regulation Western-blotting results implicated that the ATM-CHK2 pathway which is associated with G2/M arrest was phosphorylated by MALAT1 knockdown. 25613496
EL0853 MALAT1 RANKL RNA-Protein regulation We found that RANKL induced the expression of a lncRNA, MALAT1, for the first time. Knockdown of RANK by siRNA blocked the induction of MALAT1 by RANKL. In addition, MALAT1 also regulated OPG expression in hFOB 1.19 cells. 25817340
EL0853 MALAT1 PI3K-AKT pathway N/A regulation Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer. 26191181
EL0853 MALAT1 miRNA-124 RNA-RNA regulation Knockdown of MALAT1 increased the expression of miRNA-124. MALAT1 can indirectly modulate GRB2 expression via competing miR-124. 26242259
EL0853 MALAT1 TDP-43 RNA-Protein binding TDP-43 directly bound to MALAT1 RNA. Silencing TDP-43 expression effectively decreased MALAT1 RNA transcript level. In contrast, TDP-43 overexpression markedly increased MALAT1 transcript level. 26265046
EL0853 MALAT1 hsa-miR-1 RNA-RNA regulation MiR-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1. 26275461
EL0853 MALAT1 miR-145 RNA-RNA regulation miR-145 and MALAT1 were in the same Ago2 complex and there was a reciprocal repression between them. 26311052
EL0853 MALAT1 Sp1/3 DNA-Protein regulation Co-silencing of Sp1 and Sp3 synergistically repressed MALAT1 expression. Sp1 binding inhibitor, mithramycin A (MIT), also inhibited MALAT1 expression in HCC cells. 26352013
EL0853 MALAT1 EZH2 (enhancer of zeste homolog 2) and H3K27me3 RNA-Protein regulation Knockdown of MALAT1 reversed CSE-induced increases of EZH2 (enhancer of zeste homolog 2) and H3K27me3 levels. In addition to the alteration from epithelial to spindle-like mesenchymal morphology, chronic exposure of HBE cells to CSE increased the levels of EZH2, H3K27me3, vimentin, and N-cadherin and decreased E-cadherin levels, effects that were reversed by MALAT1 siRNA or EZH2 siRNA. 26415832
EL0853 MALAT1 miR-217 DNA-RNA regulation Over-expression of miR-217 with a mimic attenuated the CSE-induced increase of MALAT1 levels, and reduction of miR-217 levels by an inhibitor enhanced expression of MALAT1. MiR-217 regulation of EZH2/H3K27me3 via MALAT1 is involved in CSE-induced EMT and malignant transformation of HBE cells. 26415832
EL0853 MALAT1 miR-200s RNA-RNA binding MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. 26461224
EL0853 MALAT1 miR-1 RNA-RNA regulation There was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. 26482776
EL0853 MALAT1 EZH2 RNA-Protein binding EZH2 binds to MALAT1.The 3' end of MALAT1 interacts with the N-terminal of EZH2. 26516927
EL0853 MALAT1 N-cadherin, Vimentin, E-cadherin RNA-Protein regulation MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro. 26522444
EL0853 MALAT1 ZO-1, occludin and claudin-5 RNA-Protein regulation Knockdown of MALAT1 resulted in an impairment and increased the permeability of BTB as well as decreased the expression of ZO-1, occludin and claudin-5 in GECs. 26619802
EL0853 MALAT1 miR-140 RNA-RNA regulation There was reciprocal repression between MALAT1 and miR-140, and miR-140 mediated the effects that MALAT1 knockdown exerted. 26619802
EL0853 MALAT1 ERK/MAPK signaling N/A regulation Downregulation of MALAT1 could activate ERK/MAPK signaling and promoted proliferation in SHG139 cells. 26649728
EL0853 MALAT1 Sox2 and Nestin RNA-Protein regulation Downregulation of MALAT1 suppressed the expression of Sox2 and Nestin which are related to stemness. 26649728
EL0853 MALAT1 Hsa-miR-1 RNA-RNA regulation A reciprocal negative control relationship between MALAT1 and miR-1. 26676637
EL0853 MALAT1 pro-apoptotic proteins including cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase-1 (PARP-1). RNA-Protein regulation Reduced expression of MALAT-1 by RNA interference resulted in enhanced apoptosis in JEG-3 cells, accompanied with elevated levels of the pro-apoptotic proteins including cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase-1 (PARP-1). 26722461
EL0853 MALAT1 PCDH10 RNA-DNA regulation Long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion. 26871474
EL0853 MALAT1 EZH2 RNA-Protein binding Long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion. 26871474
EL0853 MALAT1 miR-124 RNA-RNA binding MALAT1 acted as an endogenous potent regulator by directly binding to miR-124 and down-regulating miR-124 expression. 26918449
EL0853 MALAT1 cyclin-dependent kinase 4 (CDK4) RNA-DNA regulation MALAT1 reversed the inhibitory effect of miR-124 on breast cancer proliferation and was involved in the cyclin-dependent kinase 4 (CDK4) expression. 26918449
EL0853 MALAT1 cdc42 RNA-DNA regulation MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. miR-1 bound both MALAT1 and cdc42 3'UTR directly. 26926567
EL0853 MALAT1 miR-1 RNA-RNA binding MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. 26926567
EL0859 MDC1-AS1 MDC1 RNA-DNA regulation we have identified a novel antisense lncRNA MDC1-AS, which may participate in bladder cancer through up-regulation of its antisense tumor-suppressing gene MDC1. 25514464
EL0860 Mdrl miR-361 RNA-RNA binding MDRL could directly bind to miR-361 and downregulate its expression levels, which promotes the processing of pri-miR-484. 25057983
EL0861 MEG3 cAMP DNA-TF regulation Deletion and mutation analysis suggest that a cAMP response element (CRE), located between -69 and -49 of the MEG3 proximal promoter region, is critical for promoter activity. Furthermore, gel shifting, ChIP analysis, and co-transfection experiments show that CREB directly binds to the CRE site and stimulates MEG3 promoter activity. Therefore, MEG3 is a downstream target gene of cAMP. 16793321 LncRNADisease
EL0861 MEG3 GDF15 RNA-DNA regulation We further found that MEG3 stimulates expression of the growth differentiation factor 15 (GDF15) by enhancing p53 binding to the GDF15 gene promoter. 17569660 LncRNADisease
EL0861 MEG3 p53 RNA-Protein binding We further found that MEG3 stimulates expression of the growth differentiation factor 15 (GDF15) by enhancing p53 binding to the GDF15 gene promoter. 17569660 LncRNADisease
EL0861 MEG3 p53 RNA-RNA co-expression MEG3 functions to suppress tumor cell growth, increase protein expression of the tumor suppressor p53, and selectively activate p53 target genes. 20211686 LncRNADisease
EL0861 MEG3 p53 RNA-Protein regulation The lncRNA MEG3 is a positive regulator of p53. 20951849 LncRNADisease
EL0861 MEG3 Tp53 RNA-DNA regulation The lncRNA MEG3 activates the expression of Tp53 and enhances its binding affinity to the promoter of its target gene. 21247874 LncRNADisease
EL0861 MEG3 p53 RNA-DNA regulation Putative tumour suppressor. Regulates p53 expression. Inhibits cell proliferation in the absence of p53. 21256239 LncRNADisease
EL0861 MEG3 cAMP response element-binding protein DNA-Protein binding We show that menin activates the long noncoding RNA maternally expressed gene 3 (Meg3) by histone-H3 lysine-4 trimethylation and CpG hypomethylation at the Meg3 promoter CRE site, to allow binding of the transcription factor cAMP response element-binding protein. 25565142
EL0861 MEG3 osterix, osteocalcin, BMP4 RNA-Protein regulation We observed that MEG3 knockdown significantly reduced the expression of key osteogenic markers, including Runt-related transcription factor 2, osterix, and osteocalcin, while overexpression of MEG3 enhanced their expression. Additionally, MEG3 knockdown decreased BMP4 transcription. Here we showed that MEG3 was critical for SOX2 transcriptional repression of the BMP4. 25753650
EL0861 MEG3 p53 and Bcl-xl RNA-DNA co-expression MEG3 is significantly downregulated in LAD and partially regulates the cisplatin resistance of LAD cells through the control of p53 and Bcl-xl expression. Thus, MEG3 may represent a new marker of poor response to cisplatin and could be a potential therapeutic target for LAD chemotherapy 25992654
EL0861 MEG3 Rac1 RNA-DNA regulation we also showed that Rac1 was negatively regulated by lncRNA-MEG3 at the posttranscriptional level, via a specific target site within the 3΄UTR by dual luciferase reporter assay. The expression of Rac1 was inversely correlated with lncRNA-MEG3 expression in PTC tissues. Thus, this study suggests that MEG3 acts as novel suppressor of migration and invasion by targeting Rac1 gene. 25997963
EL0861 MEG3 Bcl-2 RNA-RNA regulation Bcl-2 mRNA level was declined by MEG3 overexpression. 26223924
EL0861 MEG3 MiR-141 RNA-RNA regulation Mir-141 inhibits gastric cancer proliferation by interacting with long noncoding RNA meg3 and down-regulating e2f3 expression. 26233544
EL0861 MEG3 Bcl-2 RNA-Protein regulation MEG3 could up-regulated Bcl-2 via its competing endogenous RNA (ceRNA) activity on miR-181a. 26253106
EL0861 MEG3 miR-181 s RNA-RNA regulation MEG3 sequestering oncogenic miR-181 s in GC cells. 26253106
EL0861 MEG3 p53 RNA-Protein regulation In addition, inactivation of p53 completely abolished tumor suppression by MEG3, indicating that MEG3 tumor suppression is mediated by p53. 26284494
EL0861 MEG3 miR-21 RNA-RNA regulation Overexpression of MEG3 reduced the level of miR-21-5p expression. 26574780
EL0861 MEG3 FoxO1, G6pc, Pepck RNA-DNA regulation MEG3 overexpression significantly increased FoxO1, G6pc, Pepck mRNA expressions and hepatic gluconeogenesis and suppressed insulin-stimulated glycogen synthesis in primary hepatocytes, whereas palmitate-induced increase of FoxO1, G6pc and Pepck protein expressions could be reversed by MEG3 interference. 26603935
EL0861 MEG3 Bcl-2, Bax, activating caspase 3, Cyclin D1 RNA-Protein regulation MEG3 inhibited intrinsic cell survival pathway in vitro and in vivo by reducing the protein expression of Bcl-2, enhancing Bax and activating caspase 3. MEG3 inhibited the expression of cell cycle regulatory protein Cyclin D1 and induced cell cycle arrest in G0/G1 phase. 26610246
EL0861 MEG3 p53, caspase-3, MDM2 and cyclin D1, RNA-Protein regulation Ectopic expression of MEG3 increased p53, caspase-3 mRNA and protein levels, decreased MDM2 and cyclin D1 mRNA and protein levels, as well as ILF3 protein expression in HepG2 cells. 26647875
EL0861 MEG3 ILF3 RNA-Protein regulation ILF3 may participate in the anticancer regulation of MEG3 by interacting with MEG3. 26647875
EL0861 MEG3 DNMT1 DNA-Protein regulation DNMT1 was involved in MEG3 promoter methylation, and was inversely correlated with MEG3 expression in gliomas. DNMT1-mediated MEG3 hypermethylation caused the loss of MEG3 expression, followed by the inhibition of the p53 pathways in gliomas. 26676363
EL0861 MEG3 IFN-γ DNA-Protein regulation IFN-γ induced autophagy in infected macrophages resulted in sustained MEG3 down regulation and lack of IFN-γ allowed for counter regulation of MEG3 by viable M. bovis BCG. 26757825
EL0861 MEG3 miR-140-5p RNA-RNA regulation Pioglitazone up-regulated MEG3 expression to protect EPCs via decreasing miR-140-5p expression and increasing HDAC7 expression in MetS 26898430
EL0863 MEG8 RBII-36 snoRNA RNA-RNA regulation The novel brain-specific snorna appears to result not only from processing of the debranched lariat but also from endonucleolytic cleavages of unspliced bsr rna 11346658
EL0865 MHM DMRT1 RNA-DNA regulation Mis-expression of MHM sense and antisense sequences results in overgrowth of tissues in which transcripts are predominantly expressed. This includes altered asymmetric ovarian development in females. In males, MHM mis-expression impairs gonadal expression of the testis gene, DMRT1. Both MHM sense and antisense mis-expression cause brain abnormalities, while MHM sense causes an increase in male-biased embryo mortality. 22546690
EL0868 Mhrt Brg1 RNA-Protein binding Mhrt prevents Brg1 from recognizing its genomic DNA targets, thus inhibiting chromatin targeting and gene regulation by Brg1. It does so by binding to the helicase domain of Brg1, a domain that is crucial for tethering Brg1 to chromatinized DNA targets. 25119045
EL0869 MIAT IRES-GFP DNA-DNA regulation fusion of RNCR2 to an IRES-GFP sequence results in mislocalization of this nuclear RNA to the cytoplasm. 20459797 LncRNADisease
EL0869 MIAT SF1 RNA-Protein binding Celf3 formed novel nuclear bodies (named CS bodies) that colocalized with SF1, another Gomafu-binding protein. 25145264
EL0869 MIAT Celf3 RNA-Protein binding The RNA-binding protein Celf3 as a novel Gomafu-associating protein. Knockdown of Celf3 led to the down-regulation of Gomafu, and cross-link RNA precipitation analysis confirmed specific binding between Celf3 and Gomafu. 25145264
EL0869 MIAT Akt RNA-Protein regulation MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536
EL0869 MIAT miR-150-5p RNA-RNA regulation MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536
EL0870 Miat Oct4 DNA-TF regulation AK028326 is activated by the transcription factor OCT4. 20026622 LncRNADisease
EL0870 Miat Oct4 and Nanog RNA-DNA binding AK028326 (Oct4-activated) and AK141205 (Nanog-repressed), are direct targets of Oct4 and Nanog 20026622
EL0870 Miat BMI1 RNA-Protein regulation Our results revealed that Gomafu plays a role in mediating anxiety-like behavior and suggest that this may occur through an interaction with a key member of the polycomb repressive complex 1, BMI1, which regulates the expression of the schizophrenia-related gene beta crystallin(Crybb1). 25792222
EL0871 MIAT SF1 splicing factor RNA-Protein binding We propose that the Gomafu RNA regulates splicing efficiency by changing the local centration of splicing factors within the nucleus 21463453
EL0873 MINCR MYC RNA-DNA regulation MINCR acts as a modulator of the MYC transcriptional program. MINCR knockdown was associated with a reduction in MYC binding to the promoters of selected cell cycle genes. 26351698
EL0875 Mir124a-1hg Ptbp1 RNA-RNA co-expression Ptbp1 and AK044422 exhibit complementary expression profiles. 20137068 LncRNADisease
EL0876 Mir142hg mir-142-3p RNA-RNA co-expression Two miRNAs, mir-142-5p and mir-142-3p, recently shown to be among the most highly expressed miRNAs in naive, memory, and effector CD8 T cell populations (76), are hosted within the first intron of a long ncRNA (AK020764) that is also strongly expressed in CD8 T cells. 19494298 LncRNADisease
EL0876 Mir142hg mir-142-5p RNA-RNA co-expression Two miRNAs, mir-142-5p and mir-142-3p, recently shown to be among the most highly expressed miRNAs in naive, memory, and effector CD8 T cell populations (76), are hosted within the first intron of a long ncRNA (AK020764) that is also strongly expressed in CD8 T cells. 19494298 LncRNADisease
EL0877 MIR155HG MYB DNA-TF regulation MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. 21296997 LncRNADisease
EL0878 MIR17HG E2F1 DNA-TF regulation Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor. 20300951 LncRNADisease
EL0880 MIR31HG caspase RNA-Protein regulation Loc554202 regulated cell apoptosis partly through the activation of specific caspase cleavage cascades. 26362196
EL0880 MIR31HG E2F1 and p21 RNA-Protein regulation Knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. 26692098
EL0884 Mira Hoxa6 RNA-DNA regulation Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin. 21925392 LncRNADisease
EL0884 Mira Hoxa7 RNA-DNA regulation Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin. 21925392 LncRNADisease
EL0884 Mira MLL1 RNA-Protein binding Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting MLL1 to chromatin. 21925392 LncRNADisease
EL0884 Mira Hoxa6 and Hoxa7 RNA-DNA regulation Mira-mediated recruitment of MLL1 to the Mira gene triggers dynamic changes in chromosome onformation, culminating in activation of Hoxa6 and Hoxa7 transcription. Hoxa6 and Hoxa7 activate the expression of genes involved in germ layer specification during mESC differentiation in a cooperative and redundant fashion. Our results connect the lncRNA Mira with the recruitment of MLL1 to target genes and implicate lncRNAs in epigenetic activation of gene expression during vertebrate cell-fate determination. 21925392
EL0933 MR1 TGF-β1; PI3K inhibitor (LY294002); AKT inhibitor (GDC-0068) DNA-Protein regulation the expression of AK056155 can be enhanced by TGF-β1 in a concentration or time depended manner in HUVECs by RT-PCR. Furthermore, the expression of AK056155 was reduced with treatment of PI3K inhibitor (LY294002) or AKT inhibitor (GDC-0068) in combination with TGF-β1. 26617788
EL0938 Msx1 Msx1 RNA-RNA co-expression In vitro, Msx1 AS RNA decreased endogenous Msx1 S expression and modified Msx1 protein cell distribution.Msx1 AS RNA could also modulate Msx1 function. 18728357 LncRNADisease
EL0938 Msx1 Dlx5 RNA-RNA co-expression Transient transfection of Msx1 expression vector clearly decreased Dlx5 expression by 40–61% in 705IC5 and 705IH8 cell lines. 18728357 LncRNADisease
EL0938 Msx1 Bmp4 RNA-RNA co-expression Transient transfection of Msx1 expression vector increased Bmp4 expression by 118% and 48% in 705IC5 and 705IH8 cell lines. 18728357 LncRNADisease
EL0939 Msx1os Msx1 RNA-Protein regulation The balance between the levels of the two msx1 rnas is related to the expression of msx1 protein. 11390985
EL0939 Msx1os Msx1 RNA-RNA regulation The balance between antisense and sense msx1 mrnas appeared to control msx1 protein levels. 12489151
EL0940 MT1DP Rux2 and YAP RNA-Protein, RNA-TF regulation Rux2 and YAP were capable of inhibiting long non-coding RNA (lncRNA) 25261601
EL0941 MT1JP TIAR RNA-Protein binding By associating with the RNA-binding protein TIAR, MT1JP enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways involving p53, such as the cell cycle, apoptosis and proliferation. 26909858
EL0941 MT1JP p53 RNA-Protein regulation By associating with the RNA-binding protein TIAR, MT1JP enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways involving p53, such as the cell cycle, apoptosis and proliferation. 26909858
EL0942 Mt4 miR399 RNA-RNA binding IPS1 and At4 directly inhibits miR-399 activity.IPS1 has many family members in a number of plant species, including At4, At4–1, At4–2 and At4–3 in Arabidopsis thaliana, TPS11 in tomato, Mt4 in Barrel Clover and Alfalfa, Mt4-like in Soybean 23726911 PLNlncRbase
EL0947 MT-ND5 PTCD2 RNA-RNA regulation PTCD2 decreased the levels of ND5 lncRNA and the lncND6 RNA, which can form the 39 UTR of the ND5 mRNA. 22028365 LncRNADisease
EL0948 MT-ND6 PTCD2 RNA-RNA regulation PTCD2 decreased the levels of ND5 lncRNA and the lncND6 RNA, which can form the 39 UTR of the ND5 mRNA. 22028365 LncRNADisease
EL0950 MVIH miR-199a RNA-RNA binding Luciferase reporter assay and RNA immunoprecipitation experiment showed that miR-199a had a direct binding ability to MVIH RNA. MVIH promoted cell growth and inhibited cell apoptosis of HCC via inhibiting miR-199a expression. 26347410
EL0950 MVIH Ki67 RNA-Protein co-expression High MVIH expression was correlated with Ki67 expression. 26555546
EL0959 NALT1 NOTCH1 RNA-Protein regulation Up-regulation of NALT associating with NOTCH1 in human samples. A neighbor of NOTCH1, Lnc-RP11-611D20.2 (named NALT) which could regulate the NOTCH1 signal pathway through cis-regulation. 26330272
EL0961 NBAT1 DKK1 (dickkopf WNT signaling pathway inhibitor 1) RNA-Protein regulation DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells. 26378045
EL0961 NBAT1 EZH2 RNA-Protein regulation NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. 26378045
EL0962 NBR2 AMP-activated protein kinase (AMPK) RNA-Protein regulation NBR2 in turn interacts with AMPK and promotes AMPK kinase activity 26999735
EL0967 ncRNA-a6 Snai2 RNA-RNA co-expression Snai2 shows a significant reduction in expression when the adjacent ncRNA-a6 is depleted. 20887892 LncRNADisease
EL0967 ncRNA-a6 Snai2 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. 21502407 LncRNADisease
EL0968 ncRNACCND1 CCND1 RNA-DNA regulation Interacts with CCND1 (cyclin D1) locus and the RNA-binding protein TLS to repress CCND1 expression. 18509338 LncRNADisease
EL0968 ncRNACCND1 DROSHA RNA-Protein binding We found that knock-down of the miRNA regulator DROSHA, but not DICER, increased the expression level of CCND1ncRNA about four-fold, suggesting that CCND1ncRNA may be processed in a DROSHA-dependent manner. 20573714 LncRNADisease
EL0969 NCRUPAR PAR-1 RNA-DNA regulation The ncR-uPAR upregulated PAR-1-core promoter-driven luciferase activity and mRNA expression in vitro in a Pol II-dependent manner. This noncoding RNA appears to act in trans, albeit locally at the adjacent PAR-1 promoter. 12084570 LncRNADisease
EL0969 NCRUPAR PAR-1 RNA-Protein regulation The expression of ncRuPAR was significantly downregulated in CRC compared with paired adjacent nontumor tissues, but the level of PAR-1 mRNA in cancerous tissues was significantly higher than in adjacent normal areas. 25119598
EL0971 Nctc1 Igf2/H19 shared muscle enhancer RNA-DNA regulation Nctc1 is co-regulated with Igf2 and H19 and physically interacts with the shared muscle enhancer. In fact, all three co-regulated genes have the potential to interact not only with the shared enhancer but also with each other via their enhancer interactions. 23221643
EL0973 NEAT1 PSP-1 RNA-Protein binding The PSP-1 RNA binding domain is required for its colocalization with NEAT1 RNA in paraspeckles, and biochemical analyses support that NEAT1 RNA binds with paraspeckle proteins. 19217333 LncRNADisease
EL0973 NEAT1 DBHS RNA-Protein binding DBHS protein expression did not vary between the two cellular contexts, instead, paraspeckle induction and increased RNA nuclear retention correlated with the expression of the paraspeckle-specific structural ncRNA species NEAT1. 19720872 LncRNADisease
EL0973 NEAT1 P54NRB/NONO RNA-Protein binding NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. 19720872 LncRNADisease
EL0973 NEAT1 PSF/SFPQ RNA-Protein binding NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. 19720872 LncRNADisease
EL0973 NEAT1 PSPC1 RNA-Protein binding NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. 19720872 LncRNADisease
EL0973 NEAT1 P54nrb RNA-Protein binding a novel mechanism which is different from that reported 20211624
EL0973 NEAT1 PSP1 RNA-Protein binding NEAT1 directly interacts with the paraspeckle protein PSP1. NEAT1 knockdown abolishes paraspeckles and relaxes the constraints on export of Alu-containing RNAs into the cytoplasm. 20951849 LncRNADisease
EL0973 NEAT1 p54nrb RNA-Protein binding In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. 21444682 LncRNADisease
EL0973 NEAT1 PSF RNA-Protein binding In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. 21444682 LncRNADisease
EL0973 NEAT1 Proteins of the Drosophila behavior/human splicing RNA-Protein binding Additionally, mammalian DBHS proteins associate with the architectural long noncoding RNA NEAT1 to form paraspeckles, subnuclear bodies that alter gene expression via the nuclear retention of RNA. 22416126 LncRNADisease
EL0973 NEAT1 miR-449a RNA-RNA regulation Further study of the interaction between miR-449a and NEAT1 show that NEAT1 was up-regulated when cells were transfected with miR-449a inhibitor, and NEAT1 was down-regulated when cells transfected with miR-449a mimics. 25818739
EL0973 NEAT1 SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes RNA-Protein binding Subunits of SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes were identified as paraspeckle components that interact with PSPs and NEAT1 lncRNA. 25831520
EL0973 NEAT1 p53 RNA-Protein regulation We used isogenic lymphoma cell line models to prove p53 dependence of NEAT1 and lincRNA-p21. The current work describes the p53-dependent miRNome and identifies lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. 25971364
EL0973 NEAT1 MDTH, NM23 and MALAT1 DNA-DNA co-expression high NEAT1 expression levels were significantly associated with the expression level of MDTH, NM23 and MALAT1. 26191242
EL0973 NEAT1 miR-140 DNA-RNA binding a miR-140 binding site in NEAT1 was identifiedand and mature miR-140 in the nucleus can physically interact with NEAT1, leading to increased NEAT1 expression. 26457124
EL0973 NEAT1 miR-204/ZEB1 RNA-RNA regulation There was reciprocal repression between NEAT1 and miR-204. 27020592
EL0973 NEAT1 ZEB1 RNA-Protein regulation ZEB1 was identified as a downstream target of miR-204 and NEAT1 upregulated ZEB1 expression by negatively regulating miR-204 expression. 27020592
EL0973 NEAT1 HuR RNA-Protein binding NEAT1_1 was stabilized by an RNA-binding protein HuR, but suppressed by miR-124-3p in OC cells. 27075229
EL0973 NEAT1 miR-124-3p RNA-RNA regulation NEAT1_1 was stabilized by an RNA-binding protein HuR, but suppressed by miR-124-3p in OC cells. 27075229
EL0974 Neat1 Neat2 RNA-RNA co-expression Neat1 and Neat2 associate with nuclear paraspeckles and adjacent SC35 speckles, respectively;domains where transcription and co-transcriptional premRNA processing occur. 20137068 LncRNADisease
EL0974 Neat1 SRp40 RNA-Protein binding SRp40 associated with NEAT1, as shown by RNA-IP on days 0 and 8, but decreased on day 4, and concentrations increased over that of IgG control. 25437750
EL0975 Nespas Nesp RNA-RNA co-expression Transcription of one of its ncRNAs, the Nesp antisense (Nespas) seems important for repression of Nesp on the paternal allele. 19760321 LncRNADisease
EL0977 NKILA NF-κB/IκB RNA-Protein binding Here, we identify an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. 25759022
EL0978 Nkx2-2os Nkx2.2 RNA-DNA regulation Nkx2.2, a transcription factor that is critical for OL lineage specification, is also subject to regulation by a lncRNA, Nkx2.2AS, which is transcribed antisense to the Nkx2.2 gene. 20380817 LncRNADisease
EL0984 NONRATT021972 ERK1/2 RNA-Protein regulation NONRATT021972 siRNA inhibited the phosphorylation and activation of ERK1/2 in T2DM DRG. 26742527
EL0984 NONRATT021972 P2X3 RNA-DNA regulation The expression levels of the P2X3 protein and messenger RNA (mRNA) of T2DM rat DRG were higher compared to the control, while those in T2DM rats treated with NONRATT021972 siRNA were significantly lower compared to T2DM rats. 26742527
EL0984 NONRATT021972 TNF-α RNA-Protein regulation The level of tumor necrosis factor-α (TNF-α) in the serum of T2DM rats treated with NONRATT021972 siRNA was significantly decreased compared with T2DM rats. 26742527
EL0985 NORAD PUMILIO RNA-Protein regulation NORAD maintains genomic stability by sequestering PUMILIO proteins, which repress the stability and translation of mRNAs to which they bind. In the absence of NORAD, PUMILIO proteins drive chromosomal instability by hyperactively repressing mitotic, DNA repair, and DNA replication factors. 26724866
EL0998 npc48 miR168/miR164/miR166 RNA-RNA regulation The phenotype of 35S∷npc48 plants resembled that of 35S∷MIR168 plants, which have reduced levels of the miR168 AGO1 target, and of AGO1-sensitive miRNAs such as miR166 (Vaucheret et al. 2006). 35S∷npc48 plants also showed a decrease in miR166 accumulation, but accumulated AGO1 mRNA and miR168 at wild-type levels. In addition, 35S∷npc48 plants, but not 35S∷MIR168 plants, exhibited reduced accumulation of miR164, suggesting that npc48 could regulate a subset of miRNAs. 18997003 PLNlncRbase
EL1000 npc531 miR319 RNA-RNA regulation We identified a putative miR319 target site in npc531, but 5′ RACE-PCR analyses did not reveal any specific cleavage of this transcript in this site (data not shown) 18997003 PLNlncRbase
EL1001 npc536 AT1G67930 RNA-RNA regulation npc536 regulates the translation of AT1G67930 mRNA. 18997003, 24252906 PLNlncRbase
EL1007 NPTN-IT1 EZH2 DNA-Protein regulation lncRNA-LET is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter. The expressions of EZH2 and lncRNA-LET are significantly inversely correlated in NPC tissues. 26243049
EL1009 NR024118 SOCS3 RNA-DNA regulation NR024118 overexpression and interference significantly changed SOCS3 expression and NR024118 interference could reverse regulation of shikonin on SOCS3, proinflammatory cytokines, and MMPs expression level in MH7A cells. 26640499
EL1010 NRAV interferon-stimulated genes (ISGs) RNA-DNA regulation NRAV negatively regulates the initial transcription of multiple critical interferon-stimulated genes (ISGs), including IFITM3 and MxA, by affecting histone modification of these genes. 25525793
EL1013 NRON NFAT RNA-Protein regulation By binding to members of the nucleocytoplasmic trafficking machinery, NRON specifically inhibits the nuclear accumulation of NFAT. 19571179 LncRNADisease
EL1013 NRON NFAT RNA-Protein regulation The conserved lncRNA, named NRON,regulated the nucleocytoplasmic shuttling of the NFAT transcription factor by functioning in a nuclear pore ribonucleoprotein complex. 20951849 LncRNADisease
EL1013 NRON LRRK2 RNA-Protein binding Mechanistic studies showed that LRRK2 was a potent negative regulator of the transcription factor NFAT and was a component of a complex that included the large noncoding RNA NRON. 21983832 LncRNADisease
EL1014 NRSE REST RNA-Protein regulation The ncRNAs NRSE and HSR have been shown to regulate the activity of REST and HSF-1, respectively. 19191220 LncRNADisease
EL1015 nta-eTMX27 QPT2 RNA-DNA regulation We identified a microRNA (nta-miRX27) and also a lncRNA (nta-eTMX27) as an endogenous target mimicry (eTM) in tobacco targeting the nicotine biosynthesis key gene QPT2 encoding quinolinate phosphoribosyltransferase (QPT) and thereby regulating the nicotine content. 27172239
EL1017 NUTF2P3-001 KRAS RNA-RNA co-expression Microarray co-assay for lncRNAs and mRNAs demonstrates that lncRNA-NUTF2P3-001 is remarkably overexpressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with KRAS mRNA expression. 26755660
EL1017 NUTF2P3-001 miR-3923 RNA-RNA binding The dual-luciferase reporter assay further validates that lncRNA-NUTF2P3-001 and 3'UTR of KRAS mRNA competitively bind with miR-3923. 26755660
EL1020 OIP5-AS1 miR-424 RNA-RNA regulation miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1 26819413
EL1020 OIP5-AS1 HuR RNA-Protein binding The RNA-binding protein HuR, which enhances cell proliferation, associated with OIP5-AS1 and stabilized it. Tagging OIP5-AS1 with MS2 hairpins to identify associated microRNAs revealed that miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1. 26819413
EL1021 OR3A4P PDLIM2, MACC1, NTN4, and GNB2L1 RNA-DNA regulation OR3A4 influenced biologic functions in gastric cancer cells via regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1. 26863570
EL1024 OsIPS1 PHO2 RNA-DNA regulation OsSPX3 plays a role in OsIPS1/miR399 mediated long distance regulation on OsPHO2. 19566645 PLNlncRbase
EL1025 osk BSF RNA-Protein binding Bicoid Stability Factor (BSF) binds specifically to the C region of the mRNA. Although the C region of the osk 3' UTR is required for the noncoding function, BSF binding does not appear to be essential for that function. 26433064
EL1034 P2rx3 TNF-α RNA-Protein regulation The expression levels of TNF-α in the DRG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in the DM group. 26686228
EL1034 P2rx3 P2X3 RNA-DNA regulation The levels of P2X3 protein and mRNA in the DG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in DM rats. 26686228
EL1034 P2rx3 ERK1/2 RNA-Protein regulation The phosphorylation and activation of ERK1/2 in the DM DRG were decreased by uc.48+ siRNA treatment. 26686228
EL1044 PACERR NF-κB complexes RNA-Protein regulation The lncRNA associates with p50, a repressive subunit of NF-κB, and occludes it from the COX-2 promoter, potentially facilitating interaction with activation-competent NF-κB p65/p50 dimers. 24843008
EL1045 PAN E1B-AP5 RNA-Protein binding E1B-AP5 interacts with the PAN MRE-II motif outside of the 9-nt core in the MRE-II loop. 22043172 LncRNADisease
EL1045 PAN PABPC1 RNA-Protein binding PABPC1 binds to the 9-nt core of PAN MRE-II. 22043172 LncRNADisease
EL1046 PANDAR Bcl-2 RNA-DNA regulation PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. 25719249
EL1047 PARTICL MAT2A; G9a and SUZ12 RNA-DNA, RNA-Protein binding Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). 25900080
EL1048 Paupar PAX6 RNA-Protein binding Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein. Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is Modulated by Paupar transcript levels. 24488179
EL1051 PCA3 AR cofactors and EMT markers RNA-DNA regulation PCA3 silencing modulates the expression of key cancer-related genes, including those coding for AR cofactors and EMT markers. 26960690
EL1052 PCAT1 SUZ12 DNA-TF regulation Chromatin immunoprecipitation (ChIP) assays also demonstrated that SUZ12, a core PRC2 protein, directly binds the PCAT-1 promoter approximately 1kb upstream of the TSS. 21804560 LncRNADisease
EL1052 PCAT1 EZH2 RNA-RNA co-expression Knockdown of EZH2 by shRNA or pharmacologic inhibition of EZH2 with the inhibitor 3-deazaneplanocin A (DZNep) caused a dramatic upregulation in PCAT-1 expression levels. 21804560 LncRNADisease
EL1052 PCAT1 PRC2 RNA-Protein binding PCAT-1 is a prostate-specific regulator of cell proliferation and show that it is a target of the Polycomb Repressive Complex 2 (PRC2). Patterns of PCAT-1 and PRC2 expression stratified patient tissues into molecular subtypes distinguished by expression signatures of PCAT-1-repressed target genes. 21804560 LncRNADisease
EL1052 PCAT1 cMyc RNA-DNA regulation The PCAT-1-cMyc relationship is mediated through the post-transcriptional activity of the MYC 3' untranslated region 25425964
EL1052 PCAT1 p53 RNA-DNA regulation chromatin immunoprecipitation (ChIP) assays confirmed that PANDAR was a direct transcriptional target of p53 in NSCLC cells. 25731728
EL1055 PCAT5 ERG RNA-TF regulation PCAT5 as a regulatory target for the transcription factor ERG, which is activated in approximately 50% of human prostate cancer. 26282172
EL1056 PCAT6 KLHL12 RNA-RNA co-expression When ncRNA-a2 was depleted, the KLHL12, a gene known for its negative regulation of the Wnt-beta catenin pathway, on the opposite strand displayed a significant reduction. 20887892 LncRNADisease
EL1056 PCAT6 KLHL12 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. 21502407 LncRNADisease
EL1058 PCGEM1 miR-145 RNA-RNA regulation Downregulation of PCGEM1 expression in LNCaP cells increased expression of miR-145, while overexpression of miR-145 decreased PCGEM1 expression. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibited tumor cell proliferation, migration, and invasion, and induced early apoptosis both in vitro. In contrast, there was no effect on RWPE-1 cells. 25200485
EL1058 PCGEM1 miR-770 RNA-RNA binding Target validation showed a direct binding between PCGEM1 and miR-770. PCGEM1 act as sponge lncRNA for miR-770 that regulates proliferation/apoptosis and autophagy, and suggest PCGEM1 as possible target for OA therapy. 26340084
EL1059 PCNA-AS1 E2F RNA-Protein binding The binding of S phase-specific E2F complexes at the +583 element may help to overcome the negative effect of the antisense transcript, which results in up-regulation of PCNA expression in proliferating cells. 10488129 LncRNADisease
EL1065 PHO84 PHO84 RNA-DNA regulation Silences PHO84 in aged cells by recruiting histone deacetylases to the locus. 21256239 LncRNADisease
EL1065 PHO84 histone deacetylases RNA-Protein binding Silences PHO84 in aged cells by recruiting histone deacetylases to the locus. 21256239 LncRNADisease
EL1066 PHO84 antisense transcripts PHO84 RNA-DNA regulation the knockdown of antisense production prevents PHO84 gene repression, even in the absence of Rrp6. 18022365
EL1067 PICSAR miR-320a and miR-383 RNA-DNA regulation NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. 26539909
EL1070 PINK1-AS PU.1 mRNA RNA-RNA binding PU.1 AS lncRNA binding to PU.1 mRNA to form mRNA/AS lncRNA duplex in preadipocytes 23749759
EL1075 pncRNA-D TLS (Translocated in LipoSarcoma, also known as FUsed in Sarcoma) RNA-Protein binding The binding of TLS and pncRNA-D was affected by the presence of GGUG and GGU sequences, and the C terminal domains of TLS function in the interaction with pncRNA-D 26816614
EL1079 POU6F2-AS2 Ybx1 RNA-Protein regulation POU6F2-AS2 interacts with Ybx1 protein and regulates its chromatin localization. 27033944
EL1082 PRAL p53 RNA-Protein regulation The three stem-loop motifs at the 5' end of lncRNA-PRAL facilitated the combination of HSP90 and p53 and thus competitively inhibited MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability. 26663434
EL1084 Prep Prolyl oligopeptidase (POP) RNA-Protein regulation Knocked down lncPrep+96kb in the primary ovarian granulosa cell and a hepatic cell line, the POP expression was decreased in both cells. In contrast, overexpression of lncPrep+96kb increased the POP expression only in the granulosa cell. 24369296
EL1085 PRINS G1P3 RNA-RNA co-expression Here, we report that PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations, as demonstrated in a microarray experiment. 20377629 LncRNADisease
EL1085 PRINS RANTES RNA-Protein regulation Among HIF-1α dependent LncRNAs, PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress) was significantly up regulated in hypoxic conditions and had specific interaction with RANTES as confirmed through reporter assay. 26725683
EL1086 Prion-associated RNAs hrPrP RNA-Protein binding Shsrnas that bind to hrprp with high affinity and induce resistance to pk digestion 12946346
EL1087 pRNA PARP1 RNA-Protein binding We demonstrate that PARP1 associates with TIP5, a subunit of the NoRC complex, via the noncoding pRNA and binds to silent rRNA genes after their replication in mid-late S phase. 22405650 LncRNADisease
EL1091 PsiLNCRNA00268512 miR396e RNA-RNA regulation PsiLNCRNA00268512 regulates miR396e levels by acting as a target mimic. 26712827
EL1093 psvA antisense RNA EB4 mRNA RNA-RNA regulation The inhibition of rna synthesis during disaggregation prevents destabilization of the mrna. 1555240
EL1096 PTCSC3 S100A4 RNA-DNA regulation PTCSC3 downregulates S100A4, leading to a reduction in cell motility and invasiveness. 26274343
EL1097 PTENP1 PTEN RNA-RNA co-expression We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. 20577206 LncRNADisease
EL1099 Ptgs2os2 heterogeneous nuclear ribonucleoprotein A/B and A2/B1 RNA-Protein regulation Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. 23907535
EL1101 PU.1 AS PU.1 mRNA RNA-RNA binding The PU.1 mRNA/PU.1 AS lncRNA duplex was detected by an endogenous ribonuclease protection assay combined with RT-PCR. 25691151
EL1102 PVT1 c-Myc DNA-TF regulation PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins. 17503467 LncRNADisease
EL1102 PVT1 c-Myc RNA-DNA regulation PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins. 17503467 LncRNADisease
EL1102 PVT1 YY1 RNA-DNA regulation The risk allele (G) of rs378854 reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected. 21814516 LncRNADisease
EL1102 PVT1 P53 DNA-TF regulation The non-protein coding locus PVT1 is a p53-inducible target gene. 22110125 LncRNADisease
EL1102 PVT1 serum α-fetoprotein RNA-Protein regulation overexpression of PVT1 was associated with a higher serum α-fetoprotein expression level (P=0.011) and a higher recurrence rate (P=0.004). 25624916
EL1102 PVT1 EZH2 RNA-Protein binding we further confirmed that PVT1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of p15 and p16 25890171
EL1102 PVT1 EZH2 RNA-Protein regulation lncRNA PVT1 could be enriched by EZH2, and silencing PVT1 resulted in the decreased recruitment of EZH2. 26427660
EL1102 PVT1 cyclin D1 and TSHR RNA-Protein regulation Silenced PVT1significantly decreased cyclin D1 and TSHR expressions. 26427660
EL1102 PVT1 MYC DNA-DNA regulation Significantly lower MYC and PVT1 expression was observed during all-trans retinoic acid (ATRA)-induced differentiation and cell cycle arrest in the APL cell line. MYC knockdown in NB4 cells led to PVT1 downregulation. Moreover, PVT1 knockdown by RNA interference led to suppression of the MYC protein level, and cell proliferation was inhibited. 26544536
EL1102 PVT1 LATS2 RNA-DNA regulation PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription. 26908628
EL1102 PVT1 EZH2 RNA-Protein binding PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription. 26908628
EL1103 PWR1 FLO11 RNA-DNA regulation PWR1 could promote FLO11 transcription by interfering with ICR1 transcription. 19805129 LncRNADisease
EL1103 PWR1 Flo8 DNA-TF regulation PWR1 transcription requires Flo8 and is promoted by Rpd3L activity, but is repressed by Sfl1 function. 19805129 LncRNADisease
EL1103 PWR1 Rpd3L DNA-TF regulation PWR1 transcription requires Flo8 and is promoted by Rpd3L activity, but is repressed by Sfl1 function. 19805129 LncRNADisease
EL1103 PWR1 Sfl1 DNA-TF regulation PWR1 transcription requires Flo8 and is promoted by Rpd3L activity, but is repressed by Sfl1 function. 19805129 LncRNADisease
EL1103 PWR1 ICR1 RNA-DNA regulation The fact that low level ICR1 is detected even in sfl1 mutants suggests that ICR1 may be constitutive, supporting a model in which its levels are tuned by PWR1 transcription. 19805129 LncRNADisease
EL1107 RAD51-AS1 RAD51 RNA-Protein regulation Our results identify TPIP as a novel E2F1 co-activator, suggest a similar role for other TPTEs, and indicate that the TODRA lncRNA affects RAD51 dysregulation and RAD51-dependent DSB repair in malignancy. 26230935
EL1108 RBM4 FLJ21870 RNA-RNA co-expression Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal. 21307942 LncRNADisease
EL1108 RBM4 SERPINE1 RNA-RNA co-expression Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal. 21307942 LncRNADisease
EL1109 RBM5-AS1 RBM5 RNA-RNA co-expression These results suggest that LUST is a novel, functional, non-coding RNA that plays a role in determining the apoptotic fate of a cell by regulating the expression of RBM5 splice variants. 19559772 LncRNADisease
EL1109 RBM5-AS1 antisense strand of intron 6 RNA-DNA binding Je2, which mapped to the antisense strand of intron 6 of the putative tumour suppressor gene RBM5/LUCA-15/H37, and functioned as an apoptosis suppressor. 19559772
EL1112 RepA PRC2 RNA-Protein binding We discovered a 1.6-kilobase ncRNA (RepA) within Xist and identified the Polycomb complex, PRC2, as its direct target. 18974356 LncRNADisease
EL1112 RepA Ezh2 RNA-Protein regulation Recently, it was shown that a segment of the Xist RNA (called RepA) is important for the targeting of Ezh2 (a component of PRC2) and hence H3K27me3 to the X chromosome. 19239885 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding RepA is sufficient to recruit PRC2 to chromatin in vivo. 19571179 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. 21029862 LncRNADisease
EL1112 RepA XIST RNA-DNA regulation Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. 21256239 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. 21256239 LncRNADisease
EL1114 RGMB-AS1 RGMB RNA-Protein regulation Studies also indicated that lncRNA RGMB-AS1and RGMB were inversely correlated 26055877
EL1117 Rmrp DDX5 RNA-Protein binding The ability of DDX5 to interact with RORγt and coactivate its targets depends on intrinsic RNA helicase activity and binding of a conserved nuclear long noncoding RNA (lncRNA), Rmrp, which is mutated in patients with cartilage-hair hypoplasia. 26675721
EL1118 Rmst miR-135a RNA-RNA co-expression Ncrms serves as a host gene for miR-135a (Rodriguez et al., 2004), an oncogenic miRNA that is dysregulated in medulloblastoma. 20380817 LncRNADisease
EL1118 Rmst Pax2 DNA-TF regulation The transcription factor, Pax2, plays a role in patterning of the mouse embryonic midbrain and hindbrain, and Ncrms, a lncRNA, is specifically regulated by Pax2 in this region. 20380817 LncRNADisease
EL1119 RMST WNT5A RNA-Protein regulation tsRMST regulates Wnt and EMT signaling pathways in hESCs by repressing WNT5A, which is a potential EMT inducer for promoting in vitro differentiation of hESCs through PKC activation. 27090862
EL1120 RN7SK P-TEFb RNA-Protein regulation 7sk inhibits general and hiv-1 tat-specific transcriptional activities of p-tefb in vivo and in vitro by inhibiting the kinase activity of cdk9 and preventing recruitment of p-tefb to the hiv-1 promoter. 11713532
EL1120 RN7SK P-TEFb RNA-Protein binding The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii. 11713533
EL1120 RN7SK HEXIM1 RNA-Protein binding Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. 15201869 LncRNADisease
EL1120 RN7SK OCT1 DNA-TF regulation PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner. 1535687 LncRNADisease
EL1120 RN7SK PTF DNA-TF regulation PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner. 1535687 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding 7SK RNA binding to a HEXIM1 multimer promotes the simultaneous recruitment and hence inactivation of multiple P-TEFb units. 15994294 LncRNADisease
EL1120 RN7SK APOBEC3C RNA-Protein binding it is unclear how APOBEC3C's activity is controlled to prevent its mutations of genomic DNA. We show that most of APOBEC3C interact with about half of nuclear 7SK, which suppresses APOBEC3C's deaminase activity and sequesters APOBEC3C in the nucleolus where it could be at a safe distance from most genomic sequences. 17381310
EL1120 RN7SK BCDIN3 RNA-Protein regulation BCDIN3 is the 7SK snRNA methylphosphate capping enzyme (MePCE) present in an snRNP complex containing both RNA processing and transcription factors, including the elongation factor P-TEFb. 17643375 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding When associated with 7SK small nuclear RNA, HEXIM1 binds to P-TEFb and inhibits the kinase activity of P-TEFb. 17671421 LncRNADisease
EL1120 RN7SK LARP7 RNA-Protein binding PIP7S binds and stabilizes nearly all the nuclear 7SK via 3'-UUU-OH, leading to the sequestration and inactivation of P-TEFb. 18249148 LncRNADisease
EL1120 RN7SK LARP7 RNA-Protein binding LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. 18281698 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding HEXIM1 suppresses transcription elongation via sequestration of positive transcription elongation factor b (P-TEFb) using 7SK RNA as a scaffold. 18407829 LncRNADisease
EL1120 RN7SK PP1a RNA-Protein regulation PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. 18483222 LncRNADisease
EL1120 RN7SK PP2B RNA-Protein regulation PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. 18483222 LncRNADisease
EL1120 RN7SK LARP7 RNA-Protein binding The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. 18483487 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation 19239885 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein regulation Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation. 19239885 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding The Hexim1 binding site is located in the 24-87 region of 7SK RNA and that the protein residues outside the basic domain of Hexim1 are involved in specific RNA interactions. 19244621 LncRNADisease
EL1120 RN7SK hLARP7 RNA-Protein binding 7SK snRNP assembly by hLARP7/PIP7S 20138158 LncRNADisease
EL1120 RN7SK PIP7S RNA-Protein binding 7SK snRNP assembly by hLARP7/PIP7S 20138158 LncRNADisease
EL1120 RN7SK Tat RNA-Protein binding HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. 20471949 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements. 20675720 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding Although HEXIM1 binds tightly to 7SK RNA in vitro, release of P-TEFb from the 7SK snRNP is accompanied by the loss of HEXIM1. 20808803 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein binding Tat has been shown to bind 7SK directly and recruit P-TEFb to TAR. 20816986 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding. Tax can play a role in regulating the amount of HMW complex present in the cell by decreasing the binding of 7SK snRNP/HEXIM1 to P-TEFb. 20926576 LncRNADisease
EL1120 RN7SK Tat RNA-Protein binding Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. 20976203 LncRNADisease
EL1120 RN7SK HMGA1 RNA-Protein binding The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. 21087998 LncRNADisease
EL1120 RN7SK CDK9 RNA-Protein regulation Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. 21098020 LncRNADisease
EL1120 RN7SK HMGA1 RNA-Protein binding 7SK snRNA directly interacts through its loop2 (7SK L2) with the first A/T-hook DNA binding motif of HMGA1. 21282977 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein binding TCR signaling led to the rapid dissociation of the large inactive P-TEFb:7SK RNP (small nuclear RNA 7SK ribonucleoprotein) complex and the release of active low-molecular-weight P-TEFb complexes. 21763495 LncRNADisease
EL1120 RN7SK LARP7 RNA-Protein regulation The Lupus antigen (La)-related protein 7 (LARP7) is a constitutive component, the methylphosphate capping enzyme (MePCE) associates secondarily to phosphorylate the 5' end of 7SK snRNA. 21853533 LncRNADisease
EL1120 RN7SK HMGA1 RNA-Protein binding We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb. 21957495 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein binding We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb. 21957495 LncRNADisease
EL1120 RN7SK Ars2 RNA-Protein regulation Ars2 contributes to histone mRNA 3'end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. 22244333 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein regulation The kinase activity of P-TEFb is reversibly inhibited by formation of a complex with the 334nt 7SK RNA, from which it is released under conditions of stress. 22303389 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein binding Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. 22377309 LncRNADisease
EL1120 RN7SK P-TEFb RNA-Protein regulation Regulation of P-TEFb by the d7SK snRNP is essential for the growth and differentiation of tissues required during Drosophila development. 22379134 LncRNADisease
EL1120 RN7SK LARP7 RNA-Protein binding LARP7 negatively regulates positive transcription elongation factor-b (p-TEFb) by binding to and stabilizing 7sk RNA. 22488152 LncRNADisease
EL1120 RN7SK ABO RNA-RNA regulation Promoters pU6 and p7SK proved to express high levels of siRNA activity and can be used in the experiment of silencing alpha-1,3galactosyltransferase gene. 22522162 LncRNADisease
EL1120 RN7SK HEXIM1 RNA-Protein binding The activity of P-TEFb is negatively regulated by an RNA-binding protein HEXIM1 in association with 7SK snRNA. 22609015 LncRNADisease
EL1121 RN7SL1 BRF1 DNA-TF regulation hBRF1 functions at 7SL promoter. 10921893 LncRNADisease
EL1121 RN7SL1 SRP54 RNA-Protein binding SRP54 may be linked to the rest of SRP through this domain by a direct interaction with 7SL RNA. 1702385 LncRNADisease
EL1121 RN7SL1 APOBEC3F RNA-Protein binding Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging. 18067920 LncRNADisease
EL1121 RN7SL1 MnSOD RNA-RNA binding The 7SL cytoplasmic non-coding RNA, thought to be related to the common ancestor sequence of Alu repeats, hybridizes to the reverse-Alu-element-containing 3′UTR of the human nuclear-encoded mitochondrial MnSOD gene, repressing MnSOD expression by mechanisms distinct from control of translational initiation. 20951849 LncRNADisease
EL1121 RN7SL1 SRP19 RNA-Protein binding SRP19 synthesized in a cell-free system specifically bound to 7SL RNA. 2460823 LncRNADisease
EL1128 rncs-1 RDE-4 RNA-Protein binding rncs-1 can bind RDE-4 in vitro. 18723671 LncRNADisease
EL1128 rncs-1 Dicer RNA-Protein binding rncs-1 RNA Inhibits Dicer Cleavage,presumably by competing with dsRNA substrate for binding to Dicer or RDE-4. 18723671 LncRNADisease
EL1129 RNY1 DNA,Ro60 protein RNA-DNA binding Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication. 16943439
EL1130 roX1 MSL complex RNA-Protein binding In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of at least five proteins and two noncoding RNAs, roX1 and roX2. 15229655 LncRNADisease
EL1130 roX1 MSL1 RNA-Protein binding MSL/MSL2 is recruited by roX. 20573714 LncRNADisease
EL1130 roX1 MSL2 RNA-Protein binding MSL/MSL2 is recruited by roX. 20573714 LncRNADisease
EL1130 roX1 specific genomic sites RNA-DNA binding roX2 binds at specific genomic sites that coincide with the binding sites of proteins from the male-specific lethal complex that affects dosage compensation. 22143764
EL1131 roX2 MSL complex RNA-Protein binding In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of at least five proteins and two noncoding RNAs, roX1 and roX2. 15229655 LncRNADisease
EL1131 roX2 MSL complex RNA-Protein binding Comparison of the high-resolution map from roX2 CHART with published data for the MSL complex achieved by using ChIP revealed that roX2 binds at the same sites in chromatin as the MSL complex. 22143764 LncRNADisease
EL1154 RP11-789C1.1 XLOC_010235 RNA-RNA co-expression Via survival analysis, patients who had high-expressed XLOC_010235 or low-expressed RP11-789C1.1 showed significantly worse survival than patients with inverse-expressed XLOC_010235 or RP11-789C1.1. 26045391
EL1162 RP4-583P15.10 ZBTB46 gene RNA-DNA binding RP4-583P15.10, an up-regulated lncRNA, was found to be located downstream of the natural antisense of the ZBTB46 gene, which may regulated breast cancer through influence immune system. 25661361
EL1170 Rr18 41186 RNA-Protein binding Oct4 directly binds Tsix and Xite, two regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1. 19536159 LncRNADisease
EL1171 RRP1B PARP1 RNA-Protein binding However, it is highly unlikely that the RRP1B-PARP1 interaction is an experimental artifact, since there is loss of binding with the ΔC-term sample. 19710015 LncRNADisease
EL1171 RRP1B CSDA RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
EL1171 RRP1B H1X RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
EL1171 RRP1B TRIM28 RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
EL1171 RRP1B Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
EL1172 Rubie Bmp4 RNA-Protein regulation Rubie lies in the conserved gene desert upstream of Bmp4, within a region previously shown to be important for inner ear expression of Bmp4. the expression patterns of Bmp4 and Rubie are nearly identical in developing inner ears. 22253730
EL1175 RZE1 Znf2 RNA-DNA regulation Transcriptome analysis indicates that the loss of RZE1 reduces the transcript level of ZNF2 and Znf2's prominent downstream targets. In addition, microscopic examination using single molecule fluorescent in situ hybridization (smFISH) indicates that the loss of RZE1 increases the ratio of ZNF2 transcripts in the nucleus versus those in the cytoplasm. 26588844
EL1177 SAMMSON p32 RNA-Protein regulation SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. 27008969
EL1178 SARCC HIF-2α DNA-Protein binding HIF-2α can transcriptionally regulate the LncRNA-SARCC expression via binding to hypoxia-responsive elements on the promoter of LncRNA-SARCC. 26973243
EL1178 SARCC AR RNA-Protein binding LncRNA-SARCC can post-transcriptionally regulate androgen receptor (AR) by physically binding and destablizing AR protein to suppress AR/HIF-2α/C-MYC signals. 26973243
EL1184 SFTA3 Nkx2.1 RNA-TF regulation LL18/NANCI acts upstream of Nkx2.1 and downstream from Wnt signaling to regulate lung endoderm gene expression. 24939938
EL1188 Si lincRNA121 Si031351m, Si024403m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1189 Si lincRNA150 Si004757m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1190 Si lincRNA18 Si035406m, Si017548m, Si005742m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1191 Si lincRNA180 Si020916m, Si040853m, Si040854m, Si040872m, Si040875m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1192 Si lincRNA212 Si000320m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1193 Si lincRNA248 Si004757m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1194 Si lincRNA288 Si005770m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1195 Si lincRNA32 Si017867m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1196 Si lincRNA373 Si035268m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1197 Si lincRNA396 Si001193m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1198 Si lincRNA403 Si038221m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1199 Si lincRNA416 Si018745m, Si026655m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1200 Si lincRNA438 Si017571m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1201 Si lincRNA446 Si022090m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1203 Si lincRNA69 Si013376m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1204 Si NAT52 Si035448m, Si003758m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1205 Si NAT80 Si038715m, Si030838m, Si035819m RNA-DNA regulation Differential expression analysis showed that 19 (3.25 %) lncRNAs (17 lincRNAs and 2 NATs) in foxtail millet responded to PEG-induced drought stress 23860794 PLNlncRbase
EL1206 SIRT1-AS Sirt1 protein RNA-Protein regulation Overexpression of Sirt1 AS lncRNA increased the levels of Sirt1 protein, whereas overexpression of Sirt1 AS lncRNA mutant did not affect the level of Sirt1 protein in C2C12 cells. 24480449
EL1206 SIRT1-AS SIRT1 RNA-RNA binding SIRT1-AS bound to SIRT1 mRNA at 3'UTR, masked the miR-29c binding site and stabilized SIRT1 mRNA. 26324025
EL1208 Six3os1 Eya1 RNA-Protein binding Ezh2 and Eya1/3/4 directly bind Six3OS. 21936910 LncRNADisease
EL1208 Six3os1 Eya3 RNA-Protein binding Ezh2 and Eya1/3/4 directly bind Six3OS. 21936910 LncRNADisease
EL1208 Six3os1 Eya4 RNA-Protein binding Ezh2 and Eya1/3/4 directly bind Six3OS. 21936910 LncRNADisease
EL1208 Six3os1 Ezh2 RNA-Protein binding Ezh2 and Eya1/3/4 directly bind Six3OS. 21936910 LncRNADisease
EL1208 Six3os1 Six3 RNA-RNA co-expression Six3OS was coexpressed with Six3 in retinal progenitors. 21936910 LncRNADisease
EL1209 SKP2 Skp2 RNA-RNA regulation Meg3 and miR-3163 may coordinate suppression of translation of Skp2 mRNA in NSCLC cells to inhibit NSCLC cell growth. 26482610
EL1211 Slc44a1 Rab11b RNA-RNA co-expression A variety of ncRNAs were broadly upregulated in OLPs, PMOs and MYOs including AK141895 and AK133808, associated with the Slc44a1 and Rab11b genomic loci, respectively. 20137068 LncRNADisease
EL1211 Slc44a1 Slc44a1 RNA-RNA co-expression A variety of ncRNAs were broadly upregulated in OLPs, PMOs and MYOs including AK141895 and AK133808, associated with the Slc44a1 and Rab11b genomic loci, respectively. 20137068 LncRNADisease
EL1216 Smad7 TGF-β RNA-Protein regulation Suppression of lncRNA-Smad7 expression cancelled the anti-apoptotic function of TGF-β. In contrast, forced expression of lncRNA-Smad7 rescued apoptosis induced by a TGF-β type I receptor kinase inhibitor in the mouse breast cancer cell line JygMC(A). 24863656
EL1217 sme2 Mei2p RNA-Protein binding Meirna targets mei2 to the nucleus, where it can promote the first meiotic division. 10021358
EL1217 sme2 Mei2p RNA-Protein regulation This rna is likely to facilitate the assembly of mei2p into a dot structure and trap the protein as such in the nucleus. 11423126
EL1217 sme2 Mei2p RNA-Protein binding The dot may not be a simple reflection of the attachment of mei2p to meirna undergoing transcription. 12808043
EL1217 sme2 Mei2 RNA-Protein binding A novel, polyadenylated rna species (meirna), which suppresses this temperature-sensitive defect if overexpressed, specifically binds to mei2 both in vivo and in vitro. 7520368
EL1217 sme2 Mei2p RNA-Protein binding Mei2p binds to a polyadenylated rna molecule, meirna, loss of which blocks meiosis i. 9778252
EL1219 SNCG SNCG RNA-DNA regulation the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis. 25499222
EL1220 SNED1 Zeb2 RNA-DNA regulation Increased uc.77 led to an enhanced RNA and protein expression of Zeb2 26824344
EL1223 SNHG12 AMOT RNA-DNA regulation Upregulation of AMOT mRNA was associated with upregulation of SNHG12. The lncRNA SNHG12 promotes cell proliferation and migration by upregulating AMOT gene expression in osteosarcoma cells in vivo and in vitro. 26486328
EL1225 SNHG15 MMP2/MMP9 RNA-Protein regulation Ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression. 26662309
EL1235 Sox2ot H3 RNA-Protein regulation The expression of Sox2dot and isoforms of Sox2ot with alternative TSSs in the mouse brain is supported by the presence of H3K4me3 histone modifications associated with their promoter regions. 19767420 LncRNADisease
EL1235 Sox2ot Sox2 RNA-RNA co-expression Sox2 is a key transcription factor that is required for neural induction and maintenance of neural stem and progenitor cells, and a recent study demonstrated that the Sox2OT lncRNA, which contains the Sox2 gene within one of its introns and is transcribed in the same direction (Fantes et al., 2003), is expressed in regions of constitutive adult neurogenesis. 20380817 LncRNADisease
EL1236 SOX2-OT miR-211 RNA-RNA regulation Overexpression of miR-211 caused a significant down-regulation of both genes (SOX2OT and SOX2 genes). 26862518
EL1240 SPRY4-IT1 lipin 2 RNA-Protein binding We affinity purified SPRY4-IT1 from melanoma cells and used mass spectrometry to identify the protein lipin 2, an enzyme that converts phosphatidate to diacylglycerol (DAG), as a major binding partner. 25344859
EL1240 SPRY4-IT1 ZNF703 RNA-DNA regulation ZNF703 was a target of SPRY4-IT1 and was downregulated by SPRY4-IT1 knockdown. 25742952
EL1240 SPRY4-IT1 tight junction (TJ) mRNAs RNA-RNA regulation SPRY4-IT1 directly interacted with TJ mRNAs, and this process was enhanced through the association with the RNA-binding protein HuR. 26678886
EL1241 SRA1 mPus1p RNA-Protein regulation Mpus1p-coactivator function required sra, mpus1p-associated mrargamma binding, and pus activities. 15327771
EL1241 SRA1 MyoD RNA-Protein binding We have found that the RNA helicases p68/p72 are MyoD-associated proteins and that the noncoding RNA SRA also immunoprecipitates with MyoD. 17011493 LncRNADisease
EL1241 SRA1 p68 RNA-Protein binding One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). 17495528 LncRNADisease
EL1241 SRA1 p72 RNA-Protein binding One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). 17495528 LncRNADisease
EL1241 SRA1 CCL20 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 DIO2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 SLC2A12 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 SLC2A3 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 TBL1X RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 TGFB2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 TMEM65 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 TMPRSS2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
EL1241 SRA1 SHARP RNA-DNA regulation SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
EL1241 SRA1 SLIRP RNA-DNA regulation SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
EL1241 SRA1 TRa2 RNA-Protein binding SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
EL1241 SRA1 SRC1 RNA-Protein binding SRC1 complex is recruited by SRA. 20573714 LncRNADisease
EL1241 SRA1 MyoD RNA-RNA co-expression SRA ncRNA is known to increase the activity of a range of nuclear receptors as well as the master regulator of muscle differentiation MyoD. 20855289 LncRNADisease
EL1241 SRA1 CTCF RNA-Protein binding Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. 20966046 LncRNADisease
EL1241 SRA1 p68 RNA-Protein binding Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. 20966046 LncRNADisease
EL1241 SRA1 IGF2 RNA-RNA co-expression In vivo depletion of SRA or p68 reduced CTCF-mediated insulator activity at the IGF2/H19 ICR, increased levels of IGF2 expression, and increased interactions between the endodermal enhancer and IGF2 promoter. 20966046 LncRNADisease
EL1241 SRA1 cohesin complex RNA-Protein binding p68/SRA also interacts with members of the cohesin complex. 20966046 LncRNADisease
EL1241 SRA1 PPARG RNA-Protein binding We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPARgamma and coactivates PPARgamma-dependent reporter gene expression. 21152033 LncRNADisease
EL1241 SRA1 CTCF RNA-Protein binding DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. 21496640 LncRNADisease
EL1241 SRA1 DDX5 RNA-Protein binding DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. 21496640 LncRNADisease
EL1241 SRA1 Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
EL1241 SRA1 NANOG RNA-TF regulation NANOG was identified as a transcription factor directly interacting with SRA and co-localizing with it genome-wide in NTERA2. 26496121
EL1241 SRA1 polycomb repressive complex 2 (PRC2) RNA-Protein binding The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. 26496121
EL1241 SRA1 trithorax group (TrxG) RNA-Protein binding The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. 26496121
EL1243 SRG1 SER3 RNA-DNA binding Repression occurs by a transcription-interference mechanism in which srg1 transcription across the ser3 promoter interferes with the binding of activators. 15175754
EL1243 SRG1 Cha4 RNA-Protein binding This regulation requires Cha4, a serine-dependent activator that binds to the SRG1 promoter and is required for SRG1 induction in the presence of serine. 16291644 LncRNADisease
EL1243 SRG1 Cha4 DNA-Protein binding Srg1 transcription is regulated by serine. this regulation requires cha4, a serine-dependent activator that binds to the srg1 promoter and is required for srg1 induction in the presence of serine. 16291644
EL1243 SRG1 SER3 RNA-DNA regulation Some cases, such as the SRG1 transcript in yeast that blocks activation of the SER3 gene, involve transcriptional regulation of a protein coding gene by an ncRNA. 19191220 LncRNADisease
EL1243 SRG1 SER3 RNA-DNA regulation The 3' end of SRG1 contains regulatory elements within the SER3 promoter, and premature termination of SRG1 transcription prevents repression of SER3. 19239885 LncRNADisease
EL1243 SRG1 Spt6 RNA-Protein regulation Repression by SRG1 transcription is dependent on the Spt6 and Spt16 transcription elongation factors. 21156811 LncRNADisease
EL1243 SRG1 Spt2 RNA-Protein regulation We find that Spt2 and Spt6 are required for the repression of SER3 by SRG1 transcription. 21220514 LncRNADisease
EL1243 SRG1 Spt6 RNA-Protein regulation We find that Spt2 and Spt6 are required for the repression of SER3 by SRG1 transcription. 21220514 LncRNADisease
EL1243 SRG1 SER3 RNA-DNA regulation SRG1 transcription deposits nucleosomes over the SER3 promoter to prevent transcription factors from binding and activating SER3. 21873510 LncRNADisease
EL1244 SRP RNA SRP54M RNA-Protein binding M.jannaschii srp rna bound to human srp54m quantitatively in the absence of srp19. 10684931
EL1276 TCONS_00012273 ptr-miR172 RNA-RNA regulation ptr-miR172, which was only suppressed in compression tissue (Lu et al. 2005), may target TCONS_00012272 and TCONS_00012273 25230698 PLNlncRbase
EL1284 TCONS_00022311 GA2ox RNA-Protein regulation TCONS_00022311 was predicted to target a GA2ox 25230698 PLNlncRbase
EL1285 TCONS_00023843 Ptc-miR1448/Ptc-miR482a.2/Ptu-172/Ptu-37 RNA-RNA regulation only three of the 1377 lncRNAs (0.2 %), i.e., TCONS_00061773, TCONS_00023843 and TCONS_00048079, harbor complete precursors, for four miRNAs (Ptc-miR1448, PtcmiR482a.2, Ptu-172 and Ptu-37) 25230698 PLNlncRbase
EL1290 TCONS_00026694 POPTR_0002s09860.1 RNA-DNA regulation Similar to probable UDP-glucuronosyltransferase (EC 2.4.1.–) 25230698 PLNlncRbase
EL1292 TCONS_00032782 Pt-CSLD4 RNA-DNA regulation The lncRNA TCONS_00032782 was predicted to regulate POPTR_0013s07900.1 (Pt-CSLD4), which encodes a protein similar to cellulase synthase 3. 25230698 PLNlncRbase
EL1294 TCONS_00039944 Ptc-miR168b-5p RNA-RNA regulation miR2 (Ptc-miR168b-5p) is expressed in OW (OW [ TW[ NW), while its potential target lncRNA lmR2 (TCONS_00039944) showed its lowest expression in OW (NW [ TW [ OW). 25230698 PLNlncRbase
EL1298 TCONS_00048079 Ptc-miR1448/Ptc-miR482a.2/Ptu-172/Ptu-37 RNA-RNA regulation only three of the 1377 lncRNAs (0.2 %), i.e., TCONS_00061773, TCONS_00023843 and TCONS_00048079, harbor complete precursors, for four miRNAs (Ptc-miR1448, PtcmiR482a.2, Ptu-172 and Ptu-37) 25230698 PLNlncRbase
EL1299 TCONS_00049512 ptc-miR1445 RNA-RNA regulation ptc-miR1445 was predicted to target TCONS_00049512, which has been predicted to function in cleaving the transcripts of development-related or stressresponsive genes in Populus 25230698 PLNlncRbase
EL1300 TCONS_00053930 POPTR_0001s07400.1 RNA-DNA regulation Another target gene, predicted to be targeted by TCONS_00053930, encodes a protein similar to 4CL 25230698 PLNlncRbase
EL1303 TCONS_00056386 Pt-GA2.3 RNA-DNA regulation Genes encoding glucosyltransferases were predicted as targets of TCONS_00056386 25230698 PLNlncRbase
EL1305 TCONS_00060049 CCOMT RNA-DNA regulation TCONS_00060049 was predicted to target CCOMT, suggesting that it may have a potential role in lignin formation by regulation of CCOMT 25230698 PLNlncRbase
EL1306 TCONS_00061773 Ptc-miR1448/Ptc-miR482a.2 RNA-RNA regulation only three of the 1377 lncRNAs (0.2 %), i.e., TCONS_00061773, TCONS_00023843 and TCONS_00048079, harbor complete precursors, for four miRNAs (Ptc-miR1448, PtcmiR482a.2, Ptu-172 and Ptu-37) 25230698 PLNlncRbase
EL1321 TDRG1 FGF1 DNA-Protein regulation The increase of acetyl‑histones, H3 and H4 was diminished in the TDRG1 promoter of BMSCs that were infected with Ad‑FGF1, which indicated that the process of acetylation was promoted when the BMSCs were infected with Ad-FGF1. FGF1 induces the proliferation of BMSCs in patients with AA via promoting acetylation in lncRNA of the TDRG1 gene promoter. 26460236
EL1322 TER TERT RNA-Protein regulation Two TERs in A. thaliana. One is a conventional telomerase template. The other lncRNA negatively regulates telomerase activity in response to DNA damage, a function mediated by co-option of a transposable element. 26442096
EL1326 TGFB2-OT1 MIR4459 RNA-RNA binding FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 25437332
EL1326 TGFB2-OT1 MIR3960, MIR4488 and MIR4459 RNA-RNA binding TGFB2-OT1 acted as a competing endogenous RNA, bound to MIR3960, MIR4488 and MIR4459 26565952
EL1335 tie-1as TIE1 RNA-RNA co-expression The tie-1AS lncRNA selectively binds tie-1 mRNA in vivo and regulates tie-1 transcript levels, resulting in specific defects in endothelial cell contact junctions in vivo and in vitro. 19880500 LncRNADisease
EL1336 TINCR staufen1 (STAU1) protein RNA-Protein binding A high-throughput screen to analyse TINCR binding capacity to approximately 9,400 human recombinant proteins revealed direct binding of TINCR RNA to the staufen1 (STAU1) protein. 23201690
EL1337 TIP ncRNA Polycomb (PcG) proteins RNA-Protein regulation The relationship between TIP transcription and PcG recruitment switches dynamically during differentiation between different states, in which transcription and PcG recruitment exclude each other, or in which both are present. Reporter assays show that transcribed TIP sites can repress a flanking gene. Knockdown experiments demonstrate that TIP ncRNAs are themselves required for repression of target genes both in cis and in trans. 22336714
EL1338 TK105282 Bai3 RNA-RNA co-expression TK105282 were both co-expressed with their host gene Bai3,a brain specific inhibitor of angiogenesis. 21247874 LncRNADisease
EL1339 TK111271 Lck RNA-RNA co-expression the lncRNA TK111271 is co-expressed and co-located with Lck, a key signal gene in T-cell development. 21247874 LncRNADisease
EL1340 TK99129 Bai3 RNA-RNA co-expression TK99129 and TK105282 were both co-expressed with their host gene Bai3,a brain specific inhibitor of angiogenesis. 21247874 LncRNADisease
EL1344 Tmevp3 WDR5 RNA-Protein binding NeST RNA was found to bind WDR5, a component of the histone H3 lysine 4 methyltransferase complex, and to alter histone 3 methylation at the IFN-γ locus. 23415224
EL1344 Tmevp3 interferon-γ RNA-DNA regulation this lncRNA regulates epigenetic marking of IFN-γ-encoding chromatin, expression of IFN-γ, and susceptibility to a viral and a bacterial pathogen. 23415224
EL1348 Tog Hoxd DNA-DNA binding The start site of two opposite long noncoding RNAs (lncRNAs), Hotdog and Twin of Hotdog, selectively contacts the expressed Hoxd genes in the framework of a topological domain, coinciding with robust transcription of these genes during cecum budding. 24075990
EL1349 TP53COR1 cyclin D1, CDK4 and p21 RNA-Protein regulation Ectopic expression of lincRNA-p21 inhibited cell proliferation, arrested cycle progression and modulated cyclin D1, CDK4 and p21 expression in DLBCL cell lines. 26475621
EL1349 TP53COR1 miR-451 RNA-RNA regulation Integration of miR-451 MREs into the adenovirus efficiently delivered lincRNA-p21 into CSCs that contained low levels of miR-451. 26497997
EL1349 TP53COR1 β-catenin RNA-Protein regulation lincRNA-p21 inhibited the activity of β-catenin signaling, thereby attenuating the viability,self-renewal, and glycolysis of CSCs in vitro. 26497997
EL1350 TP53TG1 TP53 DNA-TF regulation TP53 target gene 1 9713990 LncRNADisease
EL1351 TP73-AS1 BDH2 RNA-Protein regulation LncRNA TP73-AS1 knockdown inhibited BDH2 expression in EC9706 and KYSE30 cells. 26799587
EL1352 TPS1 miR399 RNA-RNA binding INDUCED BY PHOSPHATE STARVATION1 is a member of the TPS1/Mt4 gene family that acts as a miR399 target mimic in fine tuning of PHO2 (encoding an E2 ubiquintin conjugase-related enzyme) expression and phosphate uptake in Arabidopsis, tomato and Medicago truncatula but does not encode a protein 24576388 PLNlncRbase
EL1353 TPS11 miR399 RNA-RNA binding IPS1 and At4 directly inhibits miR-399 activity.IPS1 has many family members in a number of plant species, including At4, At4–1, At4–2 and At4–3 in Arabidopsis thaliana, TPS11 in tomato, Mt4 in Barrel Clover and Alfalfa, Mt4-like in Soybean 23726911 PLNlncRbase
EL1355 TRAF3IP2-AS1 TRAF3IP2 RNA-DNA regulation TRAF3IP2-AS1 may regulate TRAF3IP2 gene expression, perhaps through local chromatin changes at this locus (right). 26222413
EL1356 TRE1 Ash1 RNA-Protein binding Ash1 is recruited by TRE1-3. 20573714 LncRNADisease
EL1357 TRE2 Ash1 RNA-Protein binding Ash1 is recruited by TRE1-3. 20573714 LncRNADisease
EL1358 TRE3 Ash1 RNA-Protein binding Ash1 is recruited by TRE1-3. 20573714 LncRNADisease
EL1363 TRERNA1 Snai1 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. Knockdown of ncRNA-a7 in A549 cells represses the expression of Snai1 specifically and diminishes cell migration to levels similar to that seen when knocking down Snai1. NcRNA-a7 serves as a transcriptional enhancer of Snai1. 21502407 LncRNADisease
EL1363 TRERNA1 miR-190a RNA-RNA regulation miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. 26608035
EL1365 Trp53cor1 p53 DNA-TF regulation lincRNA-p21 is induced by p53 in different cell systems. lincRNA-p21 as a repressor in the p53 pathway.lincRNA-p21 is a direct p53 transcriptional target in response to DNA damage. 20673990 LncRNADisease
EL1365 Trp53cor1 hnRNP-K RNA-DNA regulation The depletion of lincRNA-p21 causes a significant reduction in the association of hnRNP-K at the promoter regions of genes that are normally repressed in a lincRNA-p21 and p53-dependent fashion. 20673990 LncRNADisease
EL1365 Trp53cor1 p53 DNA-TF regulation Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k. 21256239 LncRNADisease
EL1365 Trp53cor1 hnRNP-k RNA-Protein binding Induced by p53 and mediates p53 repression of many genes in association with hnRNP-k. 21256239 LncRNADisease
EL1365 Trp53cor1 hnRNP-K RNA-Protein binding hnRNP-K interacted with a 50 domain of lincRNA-p21 that was necessary but not sufficient to induce apoptosis, suggesting that other regions of the RNA are required to recruit other factors or target the complex to chromatin or both. 21496640 LncRNADisease
EL1365 Trp53cor1 p53 RNA-DNA regulation lincRNA-p21 acts as a transcriptional repressor turning off multiple genes during the p53 response. 21496640 LncRNADisease
EL1365 Trp53cor1 p53 DNA-TF regulation p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization. 21925379 LncRNADisease
EL1365 Trp53cor1 hnRNP-K RNA-Protein binding p53 regulates lincRNA-p21 by directly inducing its expression, likely through direct binding to the lincRNA-p21 promoter, while reduction of large intergenic ncRNA (lincRNA)-p21 increases expression of numerous p53-repressed transcripts. lincRNA-p21 repressed p53-regulated genes through its binding to and modulation of heterogeneous nuclear ribonucleoprotein K (hnRNP-K) localization. 21925379 LncRNADisease
EL1365 Trp53cor1 Cdkn1a DNA-DNA co-expression LincRNA-p21 is an antisense transcript that is 15kb downstream from Cdkn1a locus and appears to be cotranscribed with the protein coding gene Cdkn1a at 8.0mg/kg furan. 23853263
EL1368 TSIX TGF-β RNA-Protein regulation The upregulation of TSIX seen in SSc fibroblasts may result from activated endogenous TGF-β signalling and may play a role in the constitutive upregulation of collagen in these cells. 26566700
EL1368 TSIX collagen RNA-RNA regulation TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA. 26566700
EL1369 Tsix XIST RNA-DNA regulation Tsix directly regulates its transcription. 16507360 LncRNADisease
EL1369 Tsix 41186 RNA-Protein binding Oct4 directly binds Tsix and Xite, two regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1. 19536159 LncRNADisease
EL1369 Tsix XIST RNA-RNA regulation For the active X, the antisense Tsix RNA is an established Xist repressor. 21029862 LncRNADisease
EL1369 Tsix XIST RNA-DNA regulation Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. 21029862 LncRNADisease
EL1369 Tsix XIST RNA-RNA regulation Xist is controlled by two parallel RNA switches – Tsix for Xa and Jpx for Xi. Tsix represses Xist on Xa. 21029862 LncRNADisease
EL1369 Tsix XIST RNA-DNA regulation Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females. 21256239 LncRNADisease
EL1369 Tsix RepA RNA-RNA regulation Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females. 21256239 LncRNADisease
EL1369 Tsix XIST RNA-DNA regulation Tsix is associated with both enrichment of the H3K4me3 active mark and prevention of the deposition of the repressive mark H3K27me3 within the body of the Xist gene. Tsix, for instance, may be subject to Xist silencing at the onset of XCI. 21329697 LncRNADisease
EL1369 Tsix XIST RNA-RNA regulation The noncoding Tsix RNA is an antisense repressor of Xist and regulates X inactivation in mice. 21852535 LncRNADisease
EL1369 Tsix Xist RNA RNA-RNA regulation Tsix is instead required to silence Xist on the active-X as epiblast cells differentiate in both males and females. 25981039
EL1372 Ttc39aos1 Pycard RNA-DNA regulation This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. 22155924
EL1374 TU1273 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1375 TU1378 GL18494 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1376 TU1403 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1378 TU1567 pheromone B alpha 3 receptor gene RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1380 TU3327 GL27846 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1385 TU4652 GL29234 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1386 TU4684 GL24376 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1387 TU4779 GL19744 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1388 TU5007 GL24914 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1389 TU506 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1390 TU51 GL30020 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1391 TU5846 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1392 TU6607 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1393 TU6608 CYP450 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1394 TU718 GL15069 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1395 TU781 GL20538 RNA-DNA regulation In the 16 lincRNA/apcGene pairs that showed significantly positive or negative correlation, 9 apcGenes are involved in wood degradation and 6 apcGenes belong to the CYP450 families, suggesting genes involved in these biological processes be potentially regulated by lincRNAs. 24932683 PLNlncRbase
EL1399 TUG1 IgG RNA-Protein binding binding with IgG shown by RIP-Chip data. 19571010 LncRNADisease
EL1399 TUG1 PRC2 RNA-Protein binding binding with PRC2 shown by RIP-Chip data. 19571010 LncRNADisease
EL1399 TUG1 p53 DNA-TF regulation TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation. 19571010 LncRNADisease
EL1399 TUG1 PRC2 RNA-Protein binding TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation. 19571010 LncRNADisease
EL1399 TUG1 PRC2 RNA-Protein binding Required for the proper formation of photoreceptors in the developing retina. Tug1 associates with PRC2 and represses a number of cell cycle genes. 21256239 LncRNADisease
EL1399 TUG1 Pc2 DNA-Protein regulation methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2. 22078878 LncRNADisease
EL1399 TUG1 polycomb repressive complex 2 (PRC2) RNA-Protein binding binding to polycomb repressive complex 2 (PRC2), 25366138
EL1399 TUG1 miR-145 RNA-RNA regulation TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner. 26318860
EL1399 TUG1 PRC2 RNA-Protein binding TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. 26336870
EL1399 TUG1 Kruppel-like factor 2 (KLF2) RNA-Protein regulation TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region. 26336870
EL1399 TUG1 Bcl-2 RNA-Protein regulation Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma. 26748401
EL1399 TUG1 caspase-3 and -9 RNA-Protein regulation Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma. 26748401
EL1399 TUG1 PTEN RNA-DNA regulation The tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. 26975529
EL1400 Tug1 PRC2 RNA-Protein binding Numerous lincRNAs are physically associated with PRC2. 19571010 LncRNADisease
EL1401 TUNAR Sox2 RNA-DNA regulation Linc00617 functions as an important regulator of EMT and promotes breast cancer progression and metastasis via activating the transcription of Sox2. 26207516
EL1402 TUSC7 P53 RNA-DNA regulation loc285194 is a p53 transcription target. 23558749
EL1402 TUSC7 Bcl2 RNA-Protein regulation After silence of TUSC7, the proapoptotic Bcl2 expression was downregulated. 26781978
EL1402 TUSC7 Eph tyrosine kinase receptor A4 (EphA4) RNA-Protein regulation TUSC7 could decrease the expression of Eph tyrosine kinase receptor A4 (EphA4), a downstream target of miR-10a as well as an EMT suppressor, through TUSC7-miR-10a-EphA4 axis. 27002617
EL1402 TUSC7 miR-10a RNA-RNA binding TUSC7 inhibited cell metastasis, invasion, and epithelial-to-mesenchymal transformation (EMT) through competitively binding miR-10a. 27002617
EL1407 uc.173 miR-291a-3p RNA-RNA regulation Uc.173 might inter-regulate with miR-291a-3p in lead-induced apoptosis and regulate apoptosis-associated genes. 26683706
EL1431 UCA1 171. C/EBPα-p30 RNA-Protein regulation we identified the oncogenic urothelial carcinoma associated 1 (UCA1) lncRNA as a novel target of the C/EBPα-p30. 26053097
EL1431 UCA1 Hyaluronoglucosaminidase 1 (HYAL1) RNA-Protein co-expression There was a significant positive correlation between HYAL1 and the selected epigenetic biomarkers. 26138586
EL1431 UCA1 AKT/mTOR pathway N/A regulation UCA1 may induce non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway and EMT. 26160838
EL1431 UCA1 Ets-2 DNA-Protein binding Ets-2 bound to the UCA1 core promoter using luciferase assays. 26238511
EL1431 UCA1 β-catenin RNA-Protein regulation CUDR causes highly upregulated in liver cancer (HULC) and β-catenin abnormal expression by inhibiting HULC promoter methylation and promoting β-catenin promoter-enhancer chromatin looping formation mediated by CUDR-ccctc-binding factor (CTCF) complex, which recruits more RNA polII and P300. 26347501
EL1431 UCA1 histone H3 twenty-seventh lysine (H3K27me3) RNA-Protein regulation CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like cells by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3). 26347501
EL1431 UCA1 miR-16 RNA-RNA regulation Urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. 26373319
EL1431 UCA1 miR-143 RNA-RNA binding There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143. 26439035
EL1431 UCA1 H19 RNA-DNA binding CUDR-CyclinD1 complex loads onto the long noncoding RNA H19 promoter region that may lead to reduce the DNA methylation on H19 promoter region and then to enhance the H19 expression. 26513297
EL1431 UCA1 C-myc RNA-DNA binding Insulator CTCF recruits the CUDR-CyclinD1 complx to form the composite CUDR-CyclinD1-insulator CTCF complex which occupancied on the C-myc gene promoter region, increasing the outcome of oncogene C-myc. 26513297
EL1431 UCA1 CyclinD1 RNA-Protein binding The decrease of PTEN in cells may lead to increase binding capacity of CUDR to CyclinD1. 26513297
EL1431 UCA1 ZEB1 and ZEB2 RNA-Protein regulation lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2) 26544536
EL1431 UCA1 hsa-miR-145 RNA-RNA binding The binding site for hsa-miR-145 within exons 2 and 3 of lncRNA-UCA1 contributed to the reciprocal negative regulation of lncRNA-UCA1 and hsa-miR-145. 26544536
EL1431 UCA1 KLF4 RNA-Protein regulation UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13. 26550172
EL1431 UCA1 SET1A RNA-Protein regulation SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically 26581161
EL1431 UCA1 miR-193a-3p RNA-RNA binding UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p. 26655272
EL1431 UCA1 MMP14 RNA-Protein regulation Depletion of UCA1 was involved in the downregulation of matrix metallopeptidase 14 (MMP14) expression, a target gene of miR-485-5p. 26867765
EL1431 UCA1 miR-485-5p RNA-RNA binding UCA1 could function as an endogenous sponge by directly binding to miR-485-5p. 26867765
EL1431 UCA1 CREB1 RNA-Protein regulation CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. 27046651
EL1431 UCA1 miR-204-5p RNA-RNA binding UCA1 could sponge endogenous miR-204-5p and inhibit its activity. 27046651
EL1434 UCHL1-AS1 UCHL1 RNA-Protein regulation In Parkinson's Disease the lncRNA UCHL1-AS1 acts by directly promoting translation of UCHL1 protein leading to perturbation of the ubiquitin-proteasome system. 27338628
EL1435 UFC1 microRNA 34a RNA-RNA regulation The lincRNA-UFC1, a target of microRNA 34a, promotes proliferation and reduces apoptosis in HCC cells to promote growth of xenograft tumors in mice. 25449213
EL1438 ULK4P2 enhancer of zeste homolog 2 RNA-DNA binding The upregulated large intergenic noncoding RNA ULK4P2 was physically combined with enhancer of zeste homolog 2. 26109807
EL1440 VAI RISC RNA-Protein binding Whereas both strands of the va rnai-specific sirna are incorporated into risc, the 3' strand of the va rnaii-specific sirna is selectively incorporated during a lytic infection. 16014917
EL1440 VAI PKR RNA-Protein binding The binding sites on inhibitor RNAs and the dsRBDs of PKR have been mapped by NMR chemical shift perturbation experiments, which indicate that inhibitors of PKR employ similar surfaces of interaction as activators. 16580685
EL1440 VAI PKR RNA-Protein binding Eber-1, eber-2 and vai rna exhibit mutually competitive binding to the native or recombinant enzyme 7901835
EL1441 VAII Dicer RNA-Protein binding The va rnas bind dicer and function as competitive substrates squelching dicer. 16014917
EL1442 Vax2os Vax2 RNA-DNA regulation We found a significant reduction of the expression levels of one of these nats, vax2os (vax2 opposite strand) in a mouse mutant carrying the inactivation of vax2, the corresponding sense gene. 15703187
EL1442 Vax2os Crx DNA-TF regulation Vax2OS was independently identified as a transcriptional target of both Crx and Nrl in a recent microarray-based screen. 19191220 LncRNADisease
EL1442 Vax2os Nrl DNA-TF regulation Vax2OS was independently identified as a transcriptional target of both Crx and Nrl in a recent microarray-based screen. 19191220 LncRNADisease
EL1443 VIM2P MMP13 and ADAMTS5 RNA-Protein regulation Silencing of lncRNA-CIR by small interfering RNA promoted the formation of collagen and aggrecan and reduced the expression of matrix-degrading enzymes, such as MMP13 and ADAMTS5. 24757148
EL1445 VL30 RNAs PSF RNA-Protein binding Mvl30 rna regulates steroidogenesis, and possibly other physiological processes of mice, by complex formation with psf. 14704271
EL1445 VL30 RNAs PSF RNA-Protein binding Psf also contains two rna-binding domains (rbd) that form a complex with a noncoding vl30 retroelement rna, releasing psf from a gene and reversing repression. 16079199
EL1451 Wbp1l Casp6 and Adrb2 RNA-DNA regulation Coding non-coding co-expression network analysis showed that the BC088414 lncRNA expression was correlated with apoptosis-related genes, including Casp6 and Adrb2. Silencing of lncRNA BC088414 in PC12 cells caused reduced mRNA level of Casp6 and Adrb2, decreased cell apoptosis and increased cell proliferation. 26349411
EL1452 WFDC21P STAT3 RNA-Protein binding lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1. 24744378
EL1454 WRAP53 TP53 RNA-RNA regulation Wrap53 regulates p53 via Wrap53/p53 RNA interaction. 19250907 LncRNADisease
EL1454 WRAP53 TP53 RNA-RNA regulation Wrap53 is a natural antisense transcript of p53 that regulates endogenous p53 mRNA levels and is furthermore required for induction of p53 protein by targeting the 5'untranslated region of p53 mRNA. 19571673 LncRNADisease
EL1455 WSPAR SWI/SNF complex RNA-Protein binding lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression 25842979
EL1455 WSPAR STAT3 RNA-Protein regulation IL-6 transcriptionally activated the expression of lncTCF7 in HCC cells by activating STAT3. 26452542
EL1455 WSPAR STAT3 RNA-Protein binding STAT3, a transcription activator which binds to promoter regions of lncTCF7. 26452542
EL1456 WT1-AS WT1 RNA-DNA binding WT1-AS downregulates WT1 by binding to the TATA region of the WT1 promotor. 26462627
EL1459 XIST H3 RNA-Protein regulation The concentration of PRC2 at the 59 end of Xist is intriguing because recruitment of PRC2 and H3-K27me3 are two of the earliest changes to occur on the X following Xist up-regulation. 19684108 LncRNADisease
EL1459 XIST PRC2 RNA-Protein binding During female development, Xist RNA is expressed from the inactive X and coats the X chromosome from which it is transcribed, leading to recruitment of Polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27 to silence transcription. 21496640 LncRNADisease
EL1459 XIST miR-152 RNA-RNA regulation miR-152 mediated the tumor-suppressive effects that knockdown of XIST exerted. 25578780
EL1460 Xist Hprt RNA-DNA regulation Loss of xist rna destabilizes the inactive state in somatic cells, leading to an increased reactivation frequency of an x-linked gfp transgene and of the endogenous hypoxanthine phosphoribosyl transferase (hprt) gene in mouse embryonic fibroblasts. 11352938
EL1460 Xist H2A RNA-Protein binding The association of the xi with macro-histone h2a is also disturbed by pna interference mapping. 11481485
EL1460 Xist TAP/NXF1 RNA-Protein binding The export factor TAP/NXF1 binds poorly to XIST RNA in comparison to exported mRNAs, suggesting that reduced TAP/NFX1 binding may contribute to nuclear retention of XIST RNA. 17333237 LncRNADisease
EL1460 Xist Dicer RNA-DNA binding In the absence of Dicer, coating by Xist RNA, initiation of silencing, and recruitment of Polycomb proteins occur normally 19164542
EL1460 Xist PRC2 RNA-Protein binding A large noncoding RNA encoded within the 5 of XIST that can target PRC2 to the inactive X chromosome. 19571010 LncRNADisease
EL1460 Xist PRC2 RNA-Protein binding The concentration of PRC2 at the 59 end of Xist is intriguing because recruitment of PRC2 and H3-K27me3 are two of the earliest changes to occur on the X following Xist up-regulation. 19684108 LncRNADisease
EL1460 Xist HNRNPU RNA-Protein binding Xist RNA and hnRNP U interact and upon depletion of hnRNP U, Xist RNA is detached from the Xi and diffusely localized into the nucleoplasm. 20833368 LncRNADisease
EL1460 Xist SAF-A RNA-Protein binding SAF-A is a plausible candidate for an anchor point of the Xist nrRNA to inactive X-chromosomes. 20940252 LncRNADisease
EL1460 Xist Rnf12 RNA-RNA co-expression Overexpression of Rnf12 ectopically induces Xist expression in XY cells. 21029862 LncRNADisease
EL1460 Xist PRC2 RNA-Protein binding Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. 21029862 LncRNADisease
EL1460 Xist PRC2 RNA-Protein binding X chromosome inactivation requires Xist, an ncRNA that coats the X and recruits Polycomb proteins. 21029862 LncRNADisease
EL1460 Xist Ezh2 RNA-Protein binding Ezh2 interacts with HOTAIR and Xist. 21123648 LncRNADisease
EL1460 Xist PRC2 RNA-Protein binding CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST. 21278485 LncRNADisease
EL1460 Xist YY1 RNA-Protein binding Here, we define the nucleation center for Xist RNA and show that YY1 docks Xist particles onto the X chromosome. 21729784 LncRNADisease
EL1460 Xist HNRNPU RNA-Protein binding Xist RNA and hnRNP U interact, and depletion of hnRNP U causes Xist to detach from the Xi and to localize diffusely in the nucleoplasm. 21925379 LncRNADisease
EL1460 Xist EZH2 RNA-Protein binding HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation. 21936910 LncRNADisease
EL1495 XLOC_007072 miR164 RNA-RNA binding identify several lncRNAs as competing endogenous RNAs (ceRNAs), which sequester miR160 or miR164 in a type of target mimicry 25517485 PLNlncRbase
EL1500 XLOC_010235 RP11-789C1.1 RNA-RNA co-expression Via survival analysis, patients who had high-expressed XLOC_010235 or low-expressed RP11-789C1.1 showed significantly worse survival than patients with inverse-expressed XLOC_010235 or RP11-789C1.1. 26045391
EL1513 Yam-1 YY1,miR-715 RNA-Protein, RNA-RNA regulation Yam-1 is positively regulated by YY1, Yam-1 is downregulated upon differentiation and acts as an inhibitor of myogenesis.Yam-1 functions through in cis regulation of miR-715, which in turn targets Wnt7b. 23942234
EL1515 ZEB1-AS1 ZEB1 RNA-DNA regulation The ZEB1-AS1 gene is located in physical contiguity with ZEB1 and positively regulates the ZEB1 expression. 26073087
EL1516 ZEB2-AS1 TGFβ1 RNA-RNA co-expression TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. 26152796
EL1517 ZFAS1 ZEB1, MMP14, and MMP16 RNA-DNA regulation ZFAS1 activated ZEB1, MMP14, and MMP16 expression, inhibiting these effects of miR-150. 26069248
EL1517 ZFAS1 miR-150 RNA-RNA binding ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. 26069248
EL1517 ZFAS1 p53 RNA-Protein regulation destabilization of p53 26506418
EL1517 ZFAS1 CDK1 RNA-Protein regulation Interaction with CDK1/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis. 26506418
EL1519 Zfhx2os zfh-5 RNA-RNA regulation This antisense rna has a negative regulatory role on the expression of zfh-5 mrna. 16257534
EL1522 Zm401 ZmMADS2, MZm3-3 and ZmC5 RNA-DNA regulation Knockdown of zm401 significantly affected the expression of ZmMADS2, MZm3-3, and ZmC5, critical genes for pollen development 21525783, 18465785, 400866 PLNlncRbase
EL1531 Apela APJ/Apelin receptors Peptide-Protein regulation Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. 24407481
EL1532 APELA APJ/Apelin receptors Peptide-Protein regulation Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. 26387754, 25639753, 20153842, 24316148, 24407481
EL1533 apela APJ/Apelin receptors Peptide-Protein regulation Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. 24407481
EL0388 ENOD40-1 nodulin 100 Peptide-Protein binding Both peptides specifically bind to the same 93-kDa protein, which was affinity purified from soybean nodules. 11842184
EL1534 Gm34302 SERCA Peptide-Protein binding Although DWORF peptides bind to the SERCA protein, they do not intrinsically activate the SERCA. Instead, DWORF displaces the binding of MLN, PLN, or SLN peptides, relieving their inhibitory activity. The DWORF peptide thus appears as an antagonist of negative regulators, competing for binding to the SERCA. 26816378
EL1535 DWORF SERCA Peptide-Protein binding DWORF localizes to the SR membrane, where it enhances SERCA activity by displacing the SERCA inhibitors, phospholamban, sarcolipin, and myoregulin. 26816378
EL1536 MRLN SERCA Peptide-Protein regulation MLN interacts directly with SERCA and impedes Ca(2+) uptake into the SR. 25640239
EL1537 Mrln SERCA Peptide-Protein regulation MLN interacts directly with SERCA and impedes Ca(2+) uptake into the SR. 25640239
EL1538 SclA SERCA Peptide-Protein binding Scl similarly to Sln and Pln binding to SERCA. 23970561
EL1539 SclB SERCA Peptide-Protein binding Scl similarly to Sln and Pln binding to SERCA. 23970561