LncRNA Information
ID EL1454 Name WRAP53 Aliases DKCB3; TCAB1; WDR79
Species Homo sapiens Chromosome 17 Start site 7686071
End site 7703502 Chain plus Exon NO. 13
Assembly Ensembl Release 89 Class retained intron NCBI accession XR_001752551
Ensembl ENSG00000141499 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
dyskeratosis congenita N/A N/A N/A mutation Disruption of telomerase trafficking by WRAP53 mutation causes dyskeratosis congenita. 21205863 LncRNADisease
cancer N/A N/A N/A N/A WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. 21368886 LncRNADisease
cancer N/A N/A N/A expression A natural antisense transcript of TP53, WRAP53, was strongly augmented by idarubicin and etoposide. 21441950 LncRNADisease
hepatocelluar carcinoma qPCR etc. HCC tissue up-regulated expression We found that lncRNA-UCA1 and lncRNA-WRAP53 were significantly higher in sera of HCC than those with chronic HCV infection or healthy volunteers. Our data suggested that the increased expression of UCA1 and WRAP53 was associated with advanced clinical parameters in HCC. 26551349 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
TP53 RNA-RNA regulation Wrap53 regulates p53 via Wrap53/p53 RNA interaction. 19250907 LncRNADisease
TP53 RNA-RNA regulation Wrap53 is a natural antisense transcript of p53 that regulates endogenous p53 mRNA levels and is furthermore required for induction of p53 protein by targeting the 5'untranslated region of p53 mRNA. 19571673 LncRNADisease