LncRNA Information | ||||||
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ID | EL1321 | Name | TDRG1 | Aliases | LINC00532 | |
Species | Homo sapiens | Chromosome | 6 | Start site | 40334954 | |
End site | 40379887 | Chain | plus | Exon NO. | 2 | |
Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_024015 | |
Ensembl | ENSG00000204091 | Sequence |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
testicular cancer | N/A | N/A | N/A | expression | The significantly reduced expression of the TDRG1 in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene. | 21243750 | LncRNADisease | ||
aplastic anemia | Reverse transcription‑quantitative polymerase chain, small interfering RNA | patients exhibiting AA | up-regulated | interaction | The decreased proliferation capability of BMSCs that were treated with Ad‑FGF1 and TDRG1‑small interfering RNA validated the vital effect of TDRG1 on the FGF1 regulatory process of BMSC differentiation. | 26460236 | |||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
FGF1 | DNA-Protein | regulation | The increase of acetyl‑histones, H3 and H4 was diminished in the TDRG1 promoter of BMSCs that were infected with Ad‑FGF1, which indicated that the process of acetylation was promoted when the BMSCs were infected with Ad-FGF1. FGF1 induces the proliferation of BMSCs in patients with AA via promoting acetylation in lncRNA of the TDRG1 gene promoter. | 26460236 | |||||