LncRNA Information
ID EL1241 Name SRA1 Aliases SRA; SRAP; STRAA1; pp7684
Species Homo sapiens Chromosome 5 Start site 140537340
End site 140558252 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class retained intron NCBI accession NR_045586, NR_045587
Ensembl ENSG00000213523 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer N/A N/A N/A expression Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines. 12565891 LncRNADisease
cardiomyopathy N/A N/A N/A N/A SRA1 results independently in a phenotype of myocardial contractile dysfunction. 19064678 LncRNADisease
dilated cardiomyopathy N/A N/A N/A expression RA also is present in a 600-kb linkage disequilibrium block associated with human dilated cardiomyopathy in 3 independent populations. 23104877 LncRNADisease
breast cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
ovarian cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
uterus cancer N/A N/A N/A regulation Co-activator of steroid Receptors & other transcription Factors; associate with metastasis 24499465 LncRNADisease
breast cancer qPCR etc. cell lines (BT-20, MDA-MB-469, MDA-MB-231 etc.) differential expression expression We recently reported a decreased estrogen receptor activity in breast cancer cells overexpressing SRAP, suggesting antagonist roles played by SRA1 RNA and SRAP. 16848684 LncRNADisease Lnc2Cancer
laryngeal squamous cell carcinoma qPCR etc. LSCC tissue down-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
breast cancer qPCR, Western blot etc. breast cancer tissue, cell line (T5) up-regulated locus We have previously found that both fully-spliced SRAP-coding and intron-1-containing non-coding SRA RNAs co-exist in breast cancer cell lines. 19483093 LncRNADisease Lnc2Cancer
breast cancer Western blot etc. cell line (HEK293T ) differential expression N/A Disturbance of the balance between SRAP1-coding and non-coding SRA1 RNAs in breast tumor tissues might be involved in breast tumorigenesis. 20079837 LncRNADisease Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A N/A interaction SRA is important for maintaining the stem cell state and for reprogramming of human fibroblasts to achieve the pluripotent state. 26496121
N/A N/A N/A epigenetics Mpus1p-dependent pseudouridylation of sra represents an additional type of posttranscriptional modification of a nr-coactivator complex that is important for nr signaling. 15327771
overexpression a transgenic-mouse model, transgenic mammary glands N/A expression Although coactivation of steroid-dependent transcription by sra is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis. 14517287
TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression SRA1 was induced in TK6 cells only. 23698766
transfected SRA, Biochemical fractionation N/A N/A expression Sra may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation. 10199399
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
mPus1p RNA-Protein regulation Mpus1p-coactivator function required sra, mpus1p-associated mrargamma binding, and pus activities. 15327771
MyoD RNA-Protein binding We have found that the RNA helicases p68/p72 are MyoD-associated proteins and that the noncoding RNA SRA also immunoprecipitates with MyoD. 17011493 LncRNADisease
p68 RNA-Protein binding One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). 17495528 LncRNADisease
p72 RNA-Protein binding One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). 17495528 LncRNADisease
CCL20 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
DIO2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
SLC2A12 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
SLC2A3 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
TBL1X RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
TGFB2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
TMEM65 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
TMPRSS2 RNA-Protein binding Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). 20219889 LncRNADisease
SHARP RNA-DNA regulation SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
SLIRP RNA-DNA regulation SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
TRa2 RNA-Protein binding SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. 20573714 LncRNADisease
SRC1 RNA-Protein binding SRC1 complex is recruited by SRA. 20573714 LncRNADisease
MyoD RNA-RNA co-expression SRA ncRNA is known to increase the activity of a range of nuclear receptors as well as the master regulator of muscle differentiation MyoD. 20855289 LncRNADisease
CTCF RNA-Protein binding Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. 20966046 LncRNADisease
p68 RNA-Protein binding Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. 20966046 LncRNADisease
IGF2 RNA-RNA co-expression In vivo depletion of SRA or p68 reduced CTCF-mediated insulator activity at the IGF2/H19 ICR, increased levels of IGF2 expression, and increased interactions between the endodermal enhancer and IGF2 promoter. 20966046 LncRNADisease
cohesin complex RNA-Protein binding p68/SRA also interacts with members of the cohesin complex. 20966046 LncRNADisease
PPARG RNA-Protein binding We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPARgamma and coactivates PPARgamma-dependent reporter gene expression. 21152033 LncRNADisease
CTCF RNA-Protein binding DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. 21496640 LncRNADisease
DDX5 RNA-Protein binding DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. 21496640 LncRNADisease
Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554
NANOG RNA-TF regulation NANOG was identified as a transcription factor directly interacting with SRA and co-localizing with it genome-wide in NTERA2. 26496121
polycomb repressive complex 2 (PRC2) RNA-Protein binding The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. 26496121
trithorax group (TrxG) RNA-Protein binding The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. 26496121