LncRNA Information
ID EL1225 Name SNHG15 Aliases C7orf40; Linc-Myo1g; MYO1GUT
Species Homo sapiens Chromosome 7 Start site 44983023
End site 44986961 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_003697
Ensembl ENSG00000232956 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
gastric cancer qPCR, Western blot, knockdown etc. gastric adenocarcinoma cancer cell lines (SGC7901, BGC823, MGC803, AGS, MKN45, GES-1) up-regulated interaction We identified a novel lncRNA SNHG15, whose expression was upregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, increased SNHG15 expression was positively correlated with invasion depth (P < 0.001), advanced tumor node metastasis (TNM) stage (P = 0.001), and lymph node metastasis (P = 0.019). SNHG15 levels were robust in differentiating GC tissues from controls (area under the curve (AUC) = 0.722; 95 % confidence interval (CI) = 0.657-0.782, P < 0.01). Kaplan-Meier analysis demonstrated that elevated SNHG15 expression contributed to poor overall survival (P < 0.01) and disease-free survival (P < 0.01) of patients. A multivariate survival analysis also indicated that SNHG15 could be an independent prognostic marker. Furthermore, knockdown of SNHG15 expression by siRNA could inhibit cell proliferation and invasion and induce apoptosis, while ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression 26662309 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
MMP2/MMP9 RNA-Protein regulation Ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression. 26662309