LncRNA Information
ID EL1224 Name SNHG14 Aliases 115HG; LNCAT; NCRNA00214; UBE3A-AS; UBE3A-AS1; UBE3AATS
Species Homo sapiens Chromosome 15 Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession N/A
Ensembl N/A Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Angelman syndrome N/A N/A N/A locus Ube3a-as is a lncRNA transcribed antisense to the maternally expressed Ube3a gene, a candidate gene for AS, suggesting that Ube3a-as may be responsible for repressing paternal Ube3a expression. 20380817 LncRNADisease
Angelman syndrome N/A N/A N/A regulation LncRNAs are also associated with imprinting disorders, such as ubiquitin protein ligase E3A (UBE3A)-ATS in Angelman syndrome. 23562612 LncRNADisease
Angelman syndrome N/A N/A N/A expression Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A 23781896 LncRNADisease
Prader-Willi syndrome N/A N/A N/A expression Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A 23781896 LncRNADisease
Angelman syndrome N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
Angelman syndrome N/A N/A N/A mutation Although in the majority of human tissues, both copies of the UBE3A gene are expressed, in neurons one copy is silenced by UBE3A-AS1 (ubiquitin-protein ligase E3A antisense RNA 1). In patients suffering from Angelman syndrome, the other (active) allele has either been deleted or inactivated. 24667321 LncRNADisease