LncRNA Information
ID EL1209 Name SKP2 Aliases FBL1; FBXL1; FLB1; p45
Species Homo sapiens Chromosome 5 Start site 36151989
End site 36184319 Chain plus Exon NO. 12
Assembly Ensembl Release 89 Class N/A NCBI accession XR_001742203
Ensembl ENSG00000145604 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
non-small cell lung cancer qPCR, Western blot etc. non-small cell lung cancer tissue, NSCLC cell lines(ATCC, Rockville, MD, USA) differential expression interaction These data suggest that the Skp2 may be regulated by Meg3 at post-transcriptional level. Bioinformatics analyses showed that miR-3163 bound to 3'-UTR of Skp2 mRNA in NSCLC cells to inhibit its translation, which was supported by luciferase reporter assay. Meg3 augmented the effects of miR-3163 on Skp2 mRNA, possibly through binding-induced function enhancement, which was supported by the double fluorescent in situ hybridization showing co-localized intracellular Meg3 and miR-3163 signals in NSCLC cells. The miR-3163 levels in NSCLC were not different from in NT, suggesting that the regulation of Skp2 in NSCLC by miR-3163 may require coordination of Meg3 26482610 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Skp2 RNA-RNA regulation Meg3 and miR-3163 may coordinate suppression of translation of Skp2 mRNA in NSCLC cells to inhibit NSCLC cell growth. 26482610