LncRNA Information
ID EL1171 Name RRP1B Aliases KIAA0179; NNP1L; Nnp1; PPP1R136; RRP1
Species Homo sapiens Chromosome 21 Start site 43659548
End site 43696079 Chain plus Exon NO. 16
Assembly Ensembl Release 89 Class retained intron NCBI accession N/A
Ensembl ENSG00000160208 Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
cancer N/A N/A N/A epigenetics RRP1B, a tumor progression and metastasis susceptibility candidate gene, is potentially a dynamic modulator of transcription and chromatin structure. 19710015 LncRNADisease
Spinocerebellar ataxia type 7 N/A N/A N/A expression CTCF is required for SCAANT1 expression. Loss of SCAANT1 derepressed ataxin-7 sense transcription in a cis-dependent fashion and was accompanied by chromatin remodeling. 21689595 LncRNADisease
Spinocerebellar ataxia type 7 N/A N/A N/A mutation For example, SCA7/ATXN7 antisense RNA 1 (SCAANT1) is an lncRNA transcribed antisense to the gene mutated in spinocerebellar ataxia type 7 (ATXN7), and it functions as a repressor of ATXN7 transcription 22814587 LncRNADisease
Spinocerebellar ataxia type 7 N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
Spinocerebellar ataxia type 7 N/A N/A N/A expression Long ncRNA SCAANT1 is implicated in a type of polyglutamine disorder, spinocerebellar ataxia type 7 (SCA7). 24624135 LncRNADisease
laryngeal squamous cell carcinoma qPCR etc. LSCC tissue down-regulated expression We discovered that five lncRNAs were differentially expressed between primary LSCC samples and adjacent normal tissues. Among them, three lncRNAs were up-expressed in tumor specimens, including CDKN2B-AS1, HOTAIR and MALAT1. More, two lncRNAs had significant down-expression, which were lncRNA RRP1B and SRA1. Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PARP1 RNA-Protein binding However, it is highly unlikely that the RRP1B-PARP1 interaction is an experimental artifact, since there is loss of binding with the ΔC-term sample. 19710015 LncRNADisease
CSDA RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
H1X RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
TRIM28 RNA-Protein binding Tandem affinity purification demonstrated that RRP1B physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 (tripartite motif-containing 28), and CSDA (cold shock domain protein A). 19710015 LncRNADisease
Cisplatin and paclitaxel N/A regulation Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. 25257554