LncRNA Information
ID EL1121 Name RN7SL1 Aliases 7L1a; 7SL; RN7SL; RNSRP1
Species Homo sapiens Chromosome 14 Start site 49586580
End site 49586878 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class N/A NCBI accession NR_002715
Ensembl ENSG00000276168 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Leishmania infection N/A N/A N/A expression Down-regulation of 7SL RNA expression and impairment of vesicular protein transport pathways by Leishmania infection of macrophages. 15955815 LncRNADisease
dermatomyositis N/A N/A N/A Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. 16142868 LncRNADisease
polymyositis N/A N/A N/A Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. 16142868 LncRNADisease
AIDS N/A N/A N/A Interaction 7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. 16489186 LncRNADisease
Leishmania infection N/A N/A N/A expression High-resolution melt analysis PCR (HRM PCR) for diagnosis of Old World Leishmania was developed using the 7SL RNA gene. Cutaneous leishmaniasis samples were analyzed. Sensitivity and specificity of HRM PCR were significantly better (P < 0.001) than those of internal transcribed spacer 1 PCR and similar to those of kinetoplast DNA PCR. 20392923 LncRNADisease
Leishmania infection N/A N/A N/A N/A The 7SL RNA PCR has proven useful for direct diagnosis of Old World leishmaniasis, especially when combined with the RBD assay for species identification. 20561310 LncRNADisease
Leishmania infection N/A N/A N/A N/A Leishmania 7SLRNA is an informative target for clinical and epidemiologic investigations of human leishmaniasis. 20856851 LncRNADisease
AIDS N/A N/A N/A N/A 7SL RNA binding is a conserved feature of human anti-HIV-1 cytidine deaminases. 20926562 LncRNADisease
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
a solid phase radioimmune assay N/A N/A expression Cellular function of 7sl-rna is as a part of srp. 6196367
N/A N/A N/A expression The rna is closely identified with the small cytoplasmic 7sl rna and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle. 6181418
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
BRF1 DNA-TF regulation hBRF1 functions at 7SL promoter. 10921893 LncRNADisease
SRP54 RNA-Protein binding SRP54 may be linked to the rest of SRP through this domain by a direct interaction with 7SL RNA. 1702385 LncRNADisease
APOBEC3F RNA-Protein binding Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging. 18067920 LncRNADisease
MnSOD RNA-RNA binding The 7SL cytoplasmic non-coding RNA, thought to be related to the common ancestor sequence of Alu repeats, hybridizes to the reverse-Alu-element-containing 3′UTR of the human nuclear-encoded mitochondrial MnSOD gene, repressing MnSOD expression by mechanisms distinct from control of translational initiation. 20951849 LncRNADisease
SRP19 RNA-Protein binding SRP19 synthesized in a cell-free system specifically bound to 7SL RNA. 2460823 LncRNADisease