LncRNA Information | ||||||
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ID | EL1119 | Name | RMST | Aliases | LINC00054; NCRMS; NCRNA00054 | |
Species | Homo sapiens | Chromosome | 12 | Start site | 97430884 | |
End site | 97598415 | Chain | plus | Exon NO. | 9 | |
Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_024037 | |
Ensembl | ENSG00000255794 | Sequence |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
rhabdomyosarcoma | qPCR, Northern blot etc. | rhabdomyosarcoma tissue | differential expression | expression | NCRMS (RMST) on chromosome 12q21 shows differential expression between rhabdomyosarcoma subtypes. | 12082533 | LncRNADisease Lnc2Cancer | ||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
N/A | anterior neural tube | up-regulated | expression | Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area | 20062813 | ||||
tsRMST knockdown cells | human pluripotent stem cells | up-regulated | N/A | disruption of tsRMST expression in hESCs results in the up-regulation of WNT5A, EMT, and lineage-specific genes/markers | 27090862 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
WNT5A | RNA-Protein | regulation | tsRMST regulates Wnt and EMT signaling pathways in hESCs by repressing WNT5A, which is a potential EMT inducer for promoting in vitro differentiation of hESCs through PKC activation. | 27090862 | |||||