LncRNA Information
ID EL1098 Name PTENP1-AS Aliases PTENP1as; PTENpg1-asRNA
Species Homo sapiens Chromosome 9 Start site 33677268
End site 33688011 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class antisense NCBI accession NR_103745
Ensembl ENSG00000281128 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
tumor N/A N/A N/A regulation We characterize a previously unidentified PTENpg1-encoded antisense RNA (asRNA), which regulates PTEN transcription and PTEN mRNA stability. We find two PTENpg1 asRNA isoforms, α and β. The α isoform functions in trans, localizes to the PTEN promoter and epigenetically modulates PTEN transcription by the recruitment of DNA methyltransferase 3a and Enhancer of Zeste. In contrast, the β isoform interacts with PTENpg1 through an RNA-RNA pairing interaction, which affects PTEN protein output through changes of PTENpg1 stability and microRNA sponge activity. 23435381 LncRNADisease