LncRNA Information
ID EL1096 Name PTCSC3 Aliases N/A
Species Homo sapiens Chromosome 14 Start site 36136108
End site 36176468 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_049735
Ensembl ENSG00000259104 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
papillary thyroid carcinoma microarray, qPCR, Western blot etc. thyroid cancer tissue, cell line (TPC-1) up-regulated interaction Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue, and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF and MMP-9 were suppressed in the presence of PTCSC3. PTC cells expressing PTCSC3 showed reduction in motility and invasiveness. 26274343 Lnc2Cancer
thyroid cancer microarray, qPCR, Western blot etc. thyroid tissue, cell lines (PTC) down-regulated expression Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue (r = 0.429, P = .0001), and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF, and MMP-9 were suppressed in the presence of PTCSC3 (P = .0051, P = .0090, and P =.0037, respectively). PTC cells expressing PTCSC3 showed reduction in motility and invasiveness 26274343 Lnc2Cancer
papillary thyroid carcinoma N/A N/A N/A mutation A thyroid-specific lncRNA, termed PTC susceptibility candidate 3 (PTCSC3), that was strongly downregulated in PTC was identified in this region and it was found that the repression was caused by the associated SNP. 23660942 LncRNADisease
papillary thyroid carcinoma N/A N/A N/A expression The study showed that the expression of PTCSC3 in six thyroid cancer cell lines is lower and no expression was detected in any of them.? 24817925 LncRNADisease
thyroid cancer qPCR etc. thyroid cancer tissue, cell lines (BCPAP, FTC133, 8505C etc.) differential expression N/A Following transfection with PTCSC3, all three thyroid cancer cells originating from various pathological types of thyroid cancers demonstrated significant growth inhibition, cell cycle arrest and increased apoptosis. So PTCSC3 as a tumor suppressor was investigated as a competing endogenous RNA for miR-574-5p. 23599737 Lnc2Cancer
papillary thyroid carcinoma qPCR, knockdown, RIP, FCA etc. PTC tissue, cell line (IHH-4) down-regulated expression The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. 26323637 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
S100A4 RNA-DNA regulation PTCSC3 downregulates S100A4, leading to a reduction in cell motility and invasiveness. 26274343