LncRNA Information
ID EL1047 Name PARTICL Aliases PARTICLE
Species Homo sapiens Chromosome 2 Start site 85537467
End site 85538886 Chain minus Exon NO. 1
Assembly GRCh38.p7 Class promoter-associated lncRNA NCBI accession NR_038942
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
low-dose irradiation In situ hybridization, surface plasmon resonance, Bromouridine tracing samples from radiotherapy-treated patients up-regulated expression Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. 25900080
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
MAT2A; G9a and SUZ12 RNA-DNA, RNA-Protein binding Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). 25900080