| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1047 | Name | PARTICL | Aliases | PARTICLE | |
| Species | Homo sapiens | Chromosome | 2 | Start site | 85537467 | |
| End site | 85538886 | Chain | minus | Exon NO. | 1 | |
| Assembly | GRCh38.p7 | Class | promoter-associated lncRNA | NCBI accession | NR_038942 | |
| Ensembl | N/A | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| low-dose irradiation | In situ hybridization, surface plasmon resonance, Bromouridine tracing | samples from radiotherapy-treated patients | up-regulated | expression | Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. | 25900080 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| MAT2A; G9a and SUZ12 | RNA-DNA, RNA-Protein | binding | Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). | 25900080 | |||||