LncRNA Information
ID EL0977 Name NKILA Aliases N/A
Species Homo sapiens Chromosome 20 Start site 57710183
End site 57712780 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class antisense NCBI accession NR_131157
Ensembl ENSG00000278709 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
nasopharyngeal carcinoma microarray, qPCR, knockdown etc. nasopharyngeal carcinoma tissue, cell lines (CNE-2 etc.) up-regulated expression Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294008) were confirmed by qPCR. 24379026 LncRNADisease Lnc2Cancer
breast cancer qPCR, knockdown, RIP etc. breast cancer tissue down-regulated interaction Importantly, NKILA is essential to prevent over-activation of NF-B pathway in inflammation-stimulated breast epithelial cells. Furthermore, low NKILA expression is associated with breast cancer metastasis and poor patient prognosis. Therefore, lncRNAs can directly interact with functional domains of signaling proteins, serving as a class of NF-B modulators to suppress cancer metastasis. 25759022 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
NF-κB/IκB RNA-Protein binding Here, we identify an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-κB/IκB, and directly masks phosphorylation motifs of IκB, thereby inhibiting IKK-induced IκB phosphorylation and NF-κB activation. 25759022