LncRNA Information
ID EL0974 Name Neat1 Aliases 2310043N10Rik; VINC
Species Mus musculus Chromosome 19 Start site 5824708
End site 5845478 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_131212, NR_003513
Ensembl ENSMUSG00000092274 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
infertility N/A N/A N/A N/A Neat1 knockout (KO) mice stochastically fail to become pregnant despite normal ovulation. Unilateral transplantation of wild-type ovaries or the administration of progesterone partially rescued the phenotype, suggesting that corpus luteum dysfunction and concomitant low progesterone were the primary causes of the decreased fertility. In contrast to the faint expression observed in most of the adult tissues, Neat1 was highly expressed in the corpus luteum, and the formation of luteal tissue was severely impaired in nearly half of the Neat1 KO mice 25359727 LncRNADisease
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
expression patterns of two long noncoding RNAs; an animal model lacking NEAT1 adult mouse tissues N/A N/A architectural integrity of nuclear bodies 21444682
expression patterns of two long noncoding RNAs;an animal model lacking NEAT1 adult mouse tissues N/A N/A architectural integrity of nuclear bodies 21444682
N/A mouse Neuro-2a cell line N/A N/A the least stable lncRNAs is the well-characterized paraspeckle RNA Neat1, Neat1's instability contributes to the dynamic nature of this subnuclear domain. 22406755
knockdown, Screening for pluripotency affects, Lineage expression affects, TF binding and regulation, Chromatin binding and overlap in expression mouse embryonic stem (ES) cells N/A interaction Neat1 has also been reported to interact with a number of chromatin binding protein/complexes in mouse embryonic stem cells including PRC1, PRC2, JARID1B, ESET and SUV39H1, with the general pattern being interaction with repressors of gene expression 21874018
RT-PCR, siRNA, RIP 3T3-L1 cells induced to differentiate by a media cocktail of insulin, dexamethasone, and isobutylmethyxanthine (IBMX) down-regulated expression Levels of NEAT1 transcript, measured by RT-PCR, fluctuated in a temporal manner over the course of differentiation that suggested its role in alternative splicing of PPARγ mRNA, the major transcription factor driving adipogenesis. 25437750
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Neat2 RNA-RNA co-expression Neat1 and Neat2 associate with nuclear paraspeckles and adjacent SC35 speckles, respectively;domains where transcription and co-transcriptional premRNA processing occur. 20137068 LncRNADisease
SRp40 RNA-Protein binding SRp40 associated with NEAT1, as shown by RNA-IP on days 0 and 8, but decreased on day 4, and concentrations increased over that of IgG control. 25437750