LncRNA Information
ID EL0961 Name NBAT1 Aliases CASC14; NBAT-1
Species Homo sapiens Chromosome 6 Start site 22134957
End site 22147193 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_034143
Ensembl ENSG00000260455 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer microarray, qPCR, Western blot, RIP, ChIP etc. cell lines (MCF-7, T47D, ZR75-1, BT-474, MDA-MB-453, BT-549, SK-BR-3 etc.) down-regulated interaction Here, we report that NBAT1 is down-regulated in various types of cancer. Particularly, reduced NBAT1 in breast cancer is associated with tumor metastasis and poor patient prognosis. In vitro, ectopic NBAT1 inhibits migration and invasion of breast cancer cells. Mechanistic study shows that NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. Among them, DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells. 26378045 Lnc2Cancer
neuroblastoma N/A N/A N/A N/A The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Loss of NBAT-1 increases cellular proliferation and invasion. 25517750 LncRNADisease
clear cell renal cell carcinoma qPCR, knockdown etc. ccRCC tissue, cell lines (786-O, ACHN, Caki-1 etc.) down-regulated expression NBAT-1 expression is significantly decreased in ccRCC tissues and renal cancer cells compared with adjacent normal tissues and normal human proximal tubule epithelial cell line HK-2, and its low level is associated with advanced features and poor prognosis. NBAT-1 is a novel molecular correlated with ccRCC progression and it may represent a prognostic biomarker and therapeutic target in renal cancer diagnosis and treatment. 26097558 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
DKK1 (dickkopf WNT signaling pathway inhibitor 1) RNA-Protein regulation DKK1 (dickkopf WNT signaling pathway inhibitor 1) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells. 26378045
EZH2 RNA-Protein regulation NBAT1 is associated with PRC2 member EZH2 and regulates global gene expression profile. 26378045