LncRNA Information
ID EL0950 Name MVIH Aliases N/A
Species Homo sapiens Chromosome 10 Start site 78033759
End site 78040713 Chain plus Exon NO. N/A
Assembly N/A Class exonic NCBI accession N/A
Ensembl N/A Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
hepatocelluar carcinoma N/A N/A N/A regulation Dr. Yuan et al. found that lncRNA-MVIH could promote tumor growth and intrahepatic metastasis by contributing to active angiogenesis both?in vitro?and?in vivo?through the inhibition of phosphoglycerate kinase 1 (PGK1) secretion 24757675 LncRNADisease
hepatocelluar carcinoma N/A N/A N/A expression Yuan et al discovered that the lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma. 24829860 LncRNADisease
hepatocelluar carcinoma qPCR etc. HCC tissues up-regulated N/A In this study, we found that lncRNA MVIH was generally overexpressed in HCC. In a cohort of 215 HCC patients, the overexpression of MVIH was associated with frequent microvascular invasion and a higher tumor node metastasis stage as well as decreased recurrence-free survival (RFS) and overall survival. We also found that MVIH could promote tumor growth and intrahepatic metastasis by activating angiogenesis in mouse models. Subsequent investigations indicated that MVIH could activate tumor-inducing angiogenesis by inhibiting the secretion of phosphoglycerate kinase 1(PGK1). 22706893 Lnc2Cancer
breast cancer qPCR, knockdown, Flow cytometry assay etc. breast cancer tissue, cell lines (MDA-MB-231, MCF-7, T47D, BT-549, UACC-812) up-regulated interaction Our research revealed that the expression levels of MVIH in breast cancer tissues were higher than in adjacent noncancerous tissues, and high MVIH expression was correlated with Ki67 expression. Moreover, breast cancer patients with high MVIH expression levels showed poor overall survival and disease-free survival. Multivariate analysis results indicated that MVIH was an independent prognostic factor in breast cancer. In addition, upregulated MVIH expression levels promoted cell proliferation and cell cycle, and inhibited cell apoptosis, while reduced MVIH expression showed the converse. 26555546 Lnc2Cancer
non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1, NCI-H1975, H1299 etc.) up-regulated regulation Long?non-coding?RNA?MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. 24793017 LncRNADisease Lnc2Cancer
microvascular invasion in hepatocellular carcinoma real-time polymerase chain reaction (PCR), Luciferase reporter assay and RNA immunoprecipitation experiment tumor tissue of HCC patients and in HCC cells, including SMMC7721 and HepG2 cells. up-regulated expression Si-MVIH inhibited HCC cell viability and promoted cell apoptosis, but this effect was reversed by miR-199a inhibitor. In nude mice with transplantation, the tumor volume was reduced by si-MVIH, and miR-199a inhibitor canceled this decrease. 26347410
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
miR-199a RNA-RNA binding Luciferase reporter assay and RNA immunoprecipitation experiment showed that miR-199a had a direct binding ability to MVIH RNA. MVIH promoted cell growth and inhibited cell apoptosis of HCC via inhibiting miR-199a expression. 26347410
Ki67 RNA-Protein co-expression High MVIH expression was correlated with Ki67 expression. 26555546