LncRNA Information
ID EL0940 Name MT1DP Aliases MTM
Species Homo sapiens Chromosome 16 Start site 56643705
End site 56644786 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_027781, NR_003658
Ensembl ENSG00000205361 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
liver cancer qPCR, Western blot, Luciferase reporter assay etc. cell lines (SMMC-7721, Bel-7402, Huh7, HepG2, DLD-1, LS174T) down-regulated interaction Overexpression of MT1DP resulted in reduced cell proliferation and colony formation in soft agar, but increased apoptosis in liver cancer cells, whereas knockdown of this lncRNA had the opposite effetc, indicating that MT1DP acts as a tumor suppressor. Furthermore, MT1DP was revealed as a negative regulator of Alfa-fetoprotein (AFP), a classic liver cancer tumor marker, through inhibiting protein synthesis of Forkhead box A1 (FoxA1), an important transcription factor in liver development and cancer progression. 25261601 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Rux2 and YAP RNA-Protein, RNA-TF regulation Rux2 and YAP were capable of inhibiting long non-coding RNA (lncRNA) 25261601