LncRNA Information
ID EL0880 Name MIR31HG Aliases LOC554202; MIR31HG
Species Homo sapiens Chromosome 9 Start site 21455642
End site 21559669 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class sense overlapping NCBI accession NR_027054
Ensembl ENSG00000171889 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer qPCR etc. cell line (MCF10A) down-regulated epigenetics miR-31 and its host gene lncRNA LOC554202 (MIR31HG) are regulated by promoter hypermethylation in triple-negative breast cancer.Both miR-31 and the host gene LOC554202 are down-regulated in the TNBC cell lines of basal subtype and over-expressed in the luminal counterparts. 22289355 LncRNADisease Lnc2Cancer
breast cancer qPCR, Western blot, knockdown etc. breast cancer tissue, cell lines (MDA-MB-231, MDA-MB-435S etc.) up-regulated regulation Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. 24631686 LncRNADisease Lnc2Cancer
gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (SGC7901, BGC823, MGC803, MKN45, GES-1) down-regulated interaction We found that MIR31HG expression is decreased in gastric cancer tissues and associated with larger tumor size and advanced pathological stage. Patients with lower MIR31HG expression had a relatively poor prognosis. Furthermore, ectopic over-expression of MIR31HG could inhibit gastric cancer (GC) cell proliferation both in vitro and in vivo, while knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. 26692098 Lnc2Cancer
colorectal cancer qPCR, Western blot, knockdown, IHC, Luciferase reporter assay etc. CRC tissue, cell lines (HCT116, DLD1, SW480, RKO, HT-29) down-regulated interaction LOC554202 was significantly downregulated in cancerous tissues and CRC cell lines compared with adjacent normal tissue and a normal human intestinal epithelial cell line. Low LOC554202 expression was closely associated with advanced pathologic stage and a larger tumor size. The overexpression of LOC554202 decreased the cell proliferation and induced apoptosis in vitro and hindered tumorigenesis in vivo. LOC554202 regulated cell apoptosis partly through the activation of specific caspase cleavage cascades. 26362196 Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A and in human Duchenne muscular dystrophy (DMD) myoblasts up-regulated N/A controlling the differentiation commitment of precursor myoblasts 25512605
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
caspase RNA-Protein regulation Loc554202 regulated cell apoptosis partly through the activation of specific caspase cleavage cascades. 26362196
E2F1 and p21 RNA-Protein regulation Knockdown of MIR31HG by small interfering RNA (siRNA) promoted cell proliferation in GC cells partly via regulating E2F1 and p21 expression. 26692098