LncRNA Information | ||||||
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ID | EL0870 | Name | Miat | Aliases | 3632434I06; A230057G18Rik; Rncr2; gomafu | |
Species | Mus musculus | Chromosome | 5 | Start site | 112213228 | |
End site | 112229395 | Chain | minus | Exon NO. | 7 | |
Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_003718, NR_033657 | |
Ensembl | ENSMUSG00000097767 | Sequence |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
neuropsychiatric disorders | RNA-seq, qRT-PCR, knockdown, ChIP, RIP | prefrontal cortex of adult mice | down-regulated | expression | lncRNAs plays an important role in the epigenetic regulation of adaptive behavior, and the perturbation of Gomafu may be related to anxiety and the development of neuropsychiatric disorders | 25792222 | |||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
combined full-length mESC transcriptome genomic mapping data with chromatin immunoprecipitation genomic location maps of the key mESC transcription factors | mouse embryonic stem cells (mESCs) | N/A | Interaction | potential roles in pluripotency | 20026622 | ||||
IRES-GFP fusion approach | mouse retinal cell | up-regulated | regulation | regulating mammalian retinal cell fate specification | 20459797 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
Oct4 | DNA-TF | regulation | AK028326 is activated by the transcription factor OCT4. | 20026622 | LncRNADisease | ||||
Oct4 and Nanog | RNA-DNA | binding | AK028326 (Oct4-activated) and AK141205 (Nanog-repressed), are direct targets of Oct4 and Nanog | 20026622 | |||||
BMI1 | RNA-Protein | regulation | Our results revealed that Gomafu plays a role in mediating anxiety-like behavior and suggest that this may occur through an interaction with a key member of the polycomb repressive complex 1, BMI1, which regulates the expression of the schizophrenia-related gene beta crystallin(Crybb1). | 25792222 | |||||