LncRNA Information | ||||||
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ID | EL0862 | Name | Meg3 | Aliases | 2900016C05Rik; 3110050O07Rik; 6330408G06Rik; AI425946; AW108224; D12Bwg1266e; Gtl2; R74756; R75394 | |
Species | Mus musculus | Chromosome | 12 | Start site | 109541001 | |
End site | 109571726 | Chain | plus | Exon NO. | 11 | |
Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_027652, NR_027651, NR_003633 | |
Ensembl | ENSMUSG00000021268 | Sequence |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
diabetes mellitus | MEG3 knockdown | STZ-induced diabetic mice | N/A | N/A | knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro | 26845358 | |||
non-functioning pituitary adenoma | Quantitative RT-PCR immunohistological | Meg3 knockout mice | up-regulated | expression | Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis | 20392836 | |||
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
compared between freshly-isolated and cultured dental mesenchymal cells | mouse dental mesenchymal cells | down-regulated in dental mesenchymal cells; up-regulated in odontogenic dental mesenchymal tissue | N/A | loss of odontogenic potential | 26986487 | ||||
Northern blot hybridizations | N/A | N/A | expression | None of the atg codons of these orfs is in the context of a strong kozak consensus sequence for initiation of translation, suggesting that gtl2 might function as an rna. primary gtl2 transcripts are differently processed in various cell types during development. | 9626496 | ||||