| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0829 | Name | AC100861.1 | Aliases | RP11-1149O23.3 | |
| Species | Homo sapiens | Chromosome | 8 | Start site | 23224471 | |
| End site | 23230926 | Chain | plus | Exon NO. | 3 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_033928 | |
| Ensembl | ENSG00000246582 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| pancreatic ductal adenocarcinoma | knockdown, overexpression | pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines | up-regulated | interaction | Knockdown of LOC389641 impaired cell proliferation and invasion and induced cell apoptosis in vitro, whereas overexpression of LOC389641 had the opposite effect. LOC389641 promotes PDAC progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A. | 26708505 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| E-cadherin | RNA-Protein | co-expression | A significant negative correlation was observed between E-cadherin levels and LOC389641 levels in vivo. Knockdown of LOC389641 upregulated E-cadherin expression, but knockdown of E-cadherin had a limited influence on LOC389641. Importantly, after E-cadherin was inhibited, the enhancement of LOC389641 on cell invasion was hindered. | 26708505 | |||||
| TNFRSF10A | DNA-DNA | regulation | The expression of LOC389641 was closely associated with its genomic neighboring gene TNFRSF10A. Lastly, knockdown experiments showed that TNFRSF10A might be a connection between LOC389641and E-cadherin. | 26708505 | |||||