| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0663 | Name | LINC00635 | Aliases | LINC00635-001 | |
| Species | Homo sapiens | Chromosome | 3 | Start site | 107840228 | |
| End site | 107882000 | Chain | minus | Exon NO. | 12 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_024276, NR_015414 | |
| Ensembl | ENSG00000241469 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| non-small cell lung cancer | microarray, qRT-PCR | gefitinib-sensitive HCC827 cells and gefitinib-resistant HCC827-8-1 cells | up-regulated | interaction | Silencing of LINC00635-001 alone did not remarkably impact HCC827-8-1 cells, but its combination with gefitinib treatment inhibited Akt activation and sensitized HCC827-8-1 cells to gefitinib-induced cytotoxicity. | 26792719 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Akt | RNA-Protein | regulation | Silencing of LINC00635-001 alone did not remarkably impact HCC827-8-1 cells, but its combination with gefitinib treatment inhibited Akt activation and sensitized HCC827-8-1 cells to gefitinib-induced cytotoxicity. | 26792719 | |||||