LncRNA Information
ID EL0569 Name HIF1A-AS1 Aliases 5'aHIF-1A; 5'aHIF1alpha
Species Homo sapiens Chromosome 14 Start site 61681041
End site 61695823 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_047116
Ensembl ENSG00000258777 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
kidney cancer N/A N/A N/A expression Diagnostic and discriminative marker 24373479 LncRNADisease
Cardiovascular disease N/A N/A N/A N/A Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro. 25761653 LncRNADisease
kidney cancer qPCR etc. renal cancer tissue up-regulated expression The antitumor DNA topoisomerase I (Top1) inhibitor camptothecin (CPT) increases the cellular levels of two antisense lncRNAs at the 5' (5'aHIF-1 alpha) and 3' (3'aHIF-1 alpha) ends of the human HIF1A-AS1 gene. 21897117 LncRNADisease Lnc2Cancer
non-small cell lung cancer qPCR etc. blood (serum), NSCLC tissue up-regulated expression The levels of XIST (P < 0.05) and HIF1A-AS1 (P < 0.05) were significantly increased in tumor tissues or serum from NSCLC patients as compared to those of control group. Moreover, serum levels of XIST and HIF1A-AS1 were significantly decreased after surgical treatment as compared to pre-operative. 26339353 Lnc2Cancer
aneurysm of the thoracoabdominal aorta RT-PCR VSMCs, serum of TAA patients up-regulated expression HIF1a-AS1 was overexpressed in the thoracoabdominal aorta aneurysm and the interaction between HIF1a-AS1 and apoptotic proteins plays a key role in the proliferation and apoptosis of VSMCs in vitro, which may contribute to the pathogenesis of thoracoabdominal aorta aneurysm. 25550800
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Real‑time polymerase chain reaction (PCR), western blot analysis, lncRNA PCR arrays and chromatin immunoprecipitation human bone marrow stromal cells down-regulated interaction HIF1α‑AS1 is an essential mediator of osteoblast differentiation. 26460121
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
HOXD10 RNA-DNA regulation Low expression of HIF1α‑AS1 was sufficient to block the expression of HOXD10. Downregulation of HOXD10 by HIF1α‑AS1 interfered with acetylation, and subsequently resulted in the inhibition of osteoblast differentiation. 26460121