LncRNA Information
ID EL0494 Name FER1L4 Aliases C20orf124
Species Homo sapiens Chromosome 20 Start site 35558737
End site 35607562 Chain minus Exon NO. 43
Assembly Ensembl Release 89 Class N/A NCBI accession NR_119376
Ensembl ENSG00000088340 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
gastric cancer microarray, qPCR etc. gastric cancer tissue down-regulated N/A FER1L4 expression levels in gastric cancer tissues are significantly decreased. The low FER1L4 level were associated with tumor size, histologic grade, general classification, depth of invasion, lymphatic metastasis , distant metastasis, TNM stage, vessel or nerve invasion.FER1L4 might play a crucial role in human gastric cancer and may be a new potential biomarker for clinical prognosis evaluation. 24961353 Lnc2Cancer
gastric cancer qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (AGS, MGC-803, SGC-7901) down-regulated interaction We observed that FER1L4 was downregulated in gastric cancer and that its level corresponded with that of PTEN mRNA. Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. Further experiments demonstrated that FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. More importantly, FER1L4 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. 26306906 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
miR-106a-5p RNA-RNA regulation Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. 26306906
PTEN RNA-RNA regulation lncRNA FER1L4 (fer-1-like family member 4, pseudogene) acts as a competing endogenous RNA (ceRNA) to regulate the expression of PTEN (a well-known tumor suppressor gene) by taking up miR-106a-5p in gastric cancer. 26306906