LncRNA Information
ID EL0491 Name FAS-AS1 Aliases FAS-AS; FASAS; SAF
Species Homo sapiens Chromosome 10 Start site 88991422
End site 88992975 Chain minus Exon NO. 1
Assembly GRCh38.p7 Class N/A NCBI accession NR_028371
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
ataxia telangiectasia N/A human T lymphocytes from patient with ataxia telangiectasia (AT) up-regulated expression FAS-AS1 was up-regulated up to fivefold by 5 Gy irradiation. This is the first study to report that FAS-AS1 lncRNA is up-regulated by radiation exposure in an ATM-dependent fashion in human T lymphocytes. 25738893
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
a culture model of human erythropoiesis erythroblasts derived from CD34(+) hematopoietic stem cell progenitor cells of healthy donors up-regulated N/A Fas-antisense 1 (Fas-AS1 or Saf) was induced during differentiation Fas-antisense 1 (Fas-AS1 or Saf) was induced during differentiation through the activity of essential erythroid transcription factors GATA-1 and KLF1 27067490
orientation-specific RT-PCR and northern blot analysis Jurkat cells N/A interaction Saf might protect t lymphocytes from fas-mediated apoptosis by blocking the binding of fasl or its agonistic fas antibody. 15829500
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Fas RNA-RNA regulation Saf might regulate the expression of Fas alternative splice forms through pre-mRNA processing. 15829500 LncRNADisease
Fas RNA-RNA regulation Saf might regulate the expression of fas alternative splice forms through pre-mrna processing. 15829500