| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0486 | Name | FALEC | Aliases | FAL1; LINC00568; ncRNA-a1 | |
| Species | Homo sapiens | Chromosome | 1 | Start site | 150515757 | |
| End site | 150518032 | Chain | plus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_051960 | |
| Ensembl | ENSG00000228126 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| ovarian cancer | knockdown | ovarian cancer cell lines | up-regulated | expression | These results demonstrate the utility of this integrated approach to identify oncogenic lncRNAs and suggest that FAL1 may represent a prognostic biomarker and therapeutic target in ovarian cancer. FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21. | 25367941 | |||
| ovarian cancer | qPCR | N/A | N/A | interaction | FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. The oncogenic activity of FAL1 is partially attributable to its repression of p21. FAL1- specific siRNAs significantly inhibit tumor growth in vivo. | 25203321 | |||
| papillary thyroid carcinoma | qRT-PCR | PTC and normal thyroid tissues | up-regulated | N/A | FAL1 expression was significantly higher in PTC | 26825907 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| ECM1 | RNA-RNA | co-expression | Depletion of ncRNA-a1 (activating long ncRNA 1, LINC00568), results in decreased ECM1 levels, suggesting a direct activating function of ncRNA-a1 on its neighboring gene. | 21502407 | LncRNADisease | ||||
| BMI1 | RNA-DNA | regulation | FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. | 25203321 | |||||
| p21 | RNA-DNA | regulation | The oncogenic activity of FAL1 is partially attributable to its repression of p21. | 25203321 | |||||
| BMI1 | RNA-Protein | regulation | The oncogenic activity of FAL1 was mediated in part by its interaction with BMI1, a component of the chromatin-modifying Polycomb repressive complex 1, which resulted in increased stabilization of BMI1 protein and transcriptional repression of genes involved in processes such as cell proliferation and apoptosis. | 25367941 | |||||