LncRNA Information
ID EL0353 Name DMTF1 Aliases DMP1; DMTF; MRUL; hDMP1
Species Homo sapiens Chromosome 7 Start site 87152361
End site 87196337 Chain plus Exon NO. 22
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_024549, NR_024550
Ensembl ENSG00000135164 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
gastric cancer microarray, qPCR, Western blot etc. cell lines (SGC7901) up-regulated N/A We show here that the lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines. 24958102 Lnc2Cancer