LncRNA Information
ID EL0350 Name Dlx6os1 Aliases A230055N17Rik; Dlx6as1; Evf-1; Evf-2; Evf1; Evf1/2; Evf2; Shhrs; mEvf-1
Species Mus musculus Chromosome 6 Start site 6820189
End site 6871592 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class antisense NCBI accession NR_015388
Ensembl ENSMUSG00000090063 Sequence


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
DLX5 RNA-DNA regulation DLX6-AS1 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. 16705037 LncRNADisease
DLX6 RNA-DNA regulation DLX6-AS1 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. 16705037 LncRNADisease
Dlx6 RNA-DNA regulation Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. 18184812 LncRNADisease
Dlx2 RNA-Protein binding Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. 18184812 LncRNADisease
Dlx6 RNA-DNA regulation Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. Consistent with this function, Evf exhibits a coincident expression profile with Dlx2. 18184812 LncRNADisease
Dlx2 RNA-Protein binding Evf2 interacts in trans with the homeobox transcription factor Dlx2 to regulate the expression of the Dlx6 gene that it encompasses. Consistent with this function, Evf exhibits a coincident expression profile with Dlx2. 18184812 LncRNADisease
DLX2 DNA-TF regulation Evf2 regulates the binding of the DLX2 transcription factor to its originating enhancer element, which in turn regulates the transcriptional activity of the enhancer. 18562676 LncRNADisease
Dlx2 RNA-Protein binding Single-stranded Evf2 forms a complex with the product of a third homeodomain gene Dlx2 whose sequence lies elsewhere in the mouse genome. 19239885 LncRNADisease
Dlx2 RNA-Protein binding The 3.8-kb Evf-2 ncRNA, which is transcribed from an ultraconserved region, forms a complex with the homeodomain-containing protein Dlx2. 19571179 LncRNADisease
Dlx6 RNA-DNA regulation Evf-2 was previously shown to regulate binding of the Dlx2 transcription factor to the ultraconserved enhancer to activate the expression of the encompassed Dlx6 gene during neurogenesis. 20137068 LncRNADisease
Dlx2 RNA-Protein binding Evf-2 was previously shown to regulate binding of the Dlx2 transcription factor to the ultraconserved enhancer to activate the expression of the encompassed Dlx6 gene during neurogenesis. 20137068 LncRNADisease
DLX DNA-TF regulation the lincRNA Evf2 is transcribed from an ultraconserved distal enhancer that recruits positive (i.e., DLX) and negative (i.e., MECP2) transcription factors to the enhancer to modulate the expression of adjacent protein-coding genes 20380817 LncRNADisease
MECP2 DNA-TF regulation the lincRNA Evf2 is transcribed from an ultraconserved distal enhancer that recruits positive (i.e., DLX) and negative (i.e., MECP2) transcription factors to the enhancer to modulate the expression of adjacent protein-coding genes 20380817 LncRNADisease
Dlx-5 RNA-DNA regulation Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
Dlx-6 RNA-DNA regulation Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
Dlx-2 RNA-Protein binding Evf2 forms a complex with Dlx-2 and recruits Dlx-2 to induce the enhancer activities of ei and eii, resulting in induced expression of both Dlx-5 and -6. 20573714 LncRNADisease
Dlx-5 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2, and is consequently an indirect positive regulator of Dlx-5 and Dlx-6. 20951849 LncRNADisease
Dlx-6 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2, and is consequently an indirect positive regulator of Dlx-5 and Dlx-6. 20951849 LncRNADisease
Dlx-2 RNA-Protein regulation The lncRNA Evf-2 is a putative direct positive regulator of the transcription factor Dlx-2. 20951849 LncRNADisease
Dlx-5/6 enhancer RNA-DNA regulation Cooperates with Dlx-2 in vivo to increase the transcriptional activity of the Dlx-5/6 enhancer. 21256239 LncRNADisease
Dlx-5/6 enhancer RNA-DNA regulation Cooperates with Dlx-2 in vivo to increase the transcriptional activity of the Dlx-5/6 enhancer. 21256239 LncRNADisease
Dlx6 RNA-DNA regulation Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease
DLX2 RNA-Protein binding Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease
MECP2 RNA-Protein binding Evf-2 modulates transcription of Dlx6 by recruiting DLX2 and MECP2 to the ultraconserved ei enhancer element that is also transcribed as part of Evf-2 itself. 21936910 LncRNADisease