LncRNA Information
ID EL0332 Name DBET Aliases DBE-T; DUX4L30
Species Homo sapiens Chromosome 4 Start site 190064502
End site 190067864 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_121644
Ensembl ENSG00000281591 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Facioscapulohumeral muscular dystrophy Gene expression study in human cells to build pathways involved by DBE-T in FSHD patients N/A N/A N/A DBE-T, a chromatin-associated noncoding RNA produced selectively in FSHD patients that coordinates de-repression of 4q35 genes. DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. 22541069
Facioscapulohumeral muscular dystrophy N/A N/A N/A mutation The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy. 22710800 LncRNADisease
Facioscapulohumeral muscular dystrophy N/A N/A N/A regulation Epigenetic deregulation of lncRNAs genes is associated with disease 23791884 LncRNADisease
Facioscapulohumeral muscular dystrophy N/A N/A N/A regulation In contrast, in FSHD patients, a deletion of D4Z4 repeats results in cis production of the DBE-T lncRNA that binds to protein complexes, reorganizes the chromatin state of the FSHD locus, and reactivates the repressed 4q35 genes. 24667321 LncRNADisease
Facioscapulohumeral muscular dystrophy N/A N/A N/A expression As a result, this region becomes more prone to transcription and gives rise to the activatory lncRNA DBE-T. DBE-T is mainly produced in FSHD patients and mediates the aberrant activation of the FSHD locus. 24685002 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Ash1L RNA-Protein regulation DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. 22541069