LncRNA Information
ID EL0311 Name CTD-3080P12.3 Aliases N/A
Species Homo sapiens Chromosome 5 Start site 1173141
End site 1178605 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class antisense NCBI accession NR_109911
Ensembl ENSG00000249201 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
gastric cancer microarray, qPCR, Western blot, Luciferase reporter assay etc. gastric cancer tissue, cell lines (KATO-III, SGC-7901, MKN28, AGS, MKN45) up-regulated interaction Here, we report that BC032469, a novel lncRNA, expressed highly in gastric cancer tissues, and the upregulation was clinically associated with larger tumor size, poor differentiation and shorter survival of gastric cancer patients. Mechanistically, BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. Thus, BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, suggesting that it may be clinically valuable as a poor prognostic biomarker of gastric cancer. 26549025 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
miR-1207-5p RNA-RNA binding BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. 26549025