LncRNA Information
ID EL0310 Name CTBP1-AS Aliases PCAT10
Species Homo sapiens Chromosome 4 Start site 1210120
End site 1218591 Chain plus Exon NO. 6
Assembly Ensembl Release 89 Class antisense NCBI accession NR_104331
Ensembl ENSG00000280927 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
prostate cancer N/A N/A N/A regulation Oncogene 24373479 LncRNADisease
prostate cancer N/A N/A N/A regulation The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. 24531795 LncRNADisease
polycystic ovary syndrome N/A N/A N/A N/A C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. Expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). 25552498 LncRNADisease
prostate cancer qPCR, Western bolt, Northern bolt, RIP etc. prostate cancer tissue, cell lines (VCaP, LNCaP, DU145, RWPE etc.) up-regulated N/A CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumour growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumour-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression. 23644382 Lnc2Cancer
hepatocellular carcinoma RT-qPCR serum N/A N/A high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients 27113935
chronic hepatitis C RT-qPCR serum N/A N/A high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients 27113935
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PSF RNA-Protein binding Binding of mouse VL30 (A130040M12Rik) retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. 23644382