LncRNA Information | ||||||
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ID | EL0293 | Name | ceruloplasmin | Aliases | NRCP | |
Species | Mus musculus | Chromosome | N/A | Start site | N/A | |
End site | N/A | Chain | N/A | Exon NO. | N/A | |
Assembly | N/A | Class | N/A | NCBI accession | N/A | |
Ensembl | N/A | Sequence | N/A |
Disease | |||||||||
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Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
ovarian cancer | knockdown | orthotopic mouse model of ovarian cancer | up-regulated | interaction | NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells. In an orthotopic mouse model of ovarian cancer, siNRCP delivered via a liposomal carrier significantly reduced tumor growth compared with control treatment. | 26686630 | |||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
STAT1 and RNA polymerase II | RNA-Protein | binding | We identified NRCP as an intermediate binding partner between STAT1 and RNA polymerase II, leading to increased expression of downstream target genes such as glucose-6-phosphate isomerase. | 26686630 | |||||